ライフサイエンスコーパス: cytidine deaminase

1 ass switch recombination (activation-induced cytidine deaminase).

2 receptors are damaged by activation-induced cytidine deaminase.

3 targeting activity of the activation-induced cytidine deaminase.

4 of the tumor stroma, and down-regulation of cytidine deaminase.

5 d deoxyguanosine resistant to degradation by cytidine deaminase.

6 ically required in the reaction catalyzed by cytidine deaminase.

7 re shown to interact with activation-induced cytidine deaminase.

8 or of transcription 3 and activation-induced cytidine deaminase.

9 ulating the expression of activation-induced cytidine deaminase.

10 on of dG:dU mismatches by activation-induced cytidine deaminase.

11 he B cell-specific factor activation-induced cytidine deaminase.

12 nsity that are targets of activation-induced cytidine deaminase.

13 of Dnd1 is related to Apobec1 activity as a cytidine deaminase.

14 similar to the action of activation-induced cytidine deaminase.

15 , and Blimp-1, and of the activation-induced cytidine deaminase.

16 (RESCUE), by directly evolving ADAR2 into a cytidine deaminase.

17 ature B cells mediated by activation-induced cytidine deaminase.

18 to a defective BLM and the downregulation of cytidine deaminase.

19 ociation with lineage-specific expression of cytidine deaminases.

20 tivating host antiviral factors, the APOBEC3 cytidine deaminases.

21 (A3B), a member of the AID/APOBEC family of cytidine deaminases.

22 d major source of mutation in cancer, APOBEC cytidine deaminases.

23 lieved, and that this is largely due to host cytidine deaminases.

24 nding motif that shares characteristics with cytidine deaminases.

25 enzyme, catalytic polypeptide-like (APOBEC) cytidine deaminases.

26 o T base editing by both rAPOBEC1 and PmCDA1 cytidine deaminases.

27 Expression of cytidine deaminase, a dC-catabolizing enzyme, in leukemi

28 The human APOBEC3 family consists of seven cytidine deaminases (A3A to A3H), some of which display

29 Although APOBEC3 cytidine deaminases A3G, A3F, A3D and A3H are packaged i

30 se findings indicate that activation-induced cytidine deaminase acting on V-region sequences is suffi

31 The DNA cytidine deaminase activation-induced deaminase (AID) ca

32 ctors contains residues conserved with known cytidine deaminase active sites; however, some PPR editi

33 We also queried the data for cytidine deaminase activity on the viral genome, which c

34 Moreover, whether APOBEC3G cytidine deaminase activity transcends to processing cel

35 ect cells and demonstrated that it possesses cytidine deaminase activity, as expected.

36 ations, and mutations associated with APOBEC cytidine deaminase activity.

37 uplex and, despite the bound RNA, has potent cytidine deaminase activity.

38 Unlike for bacterial cytidine deaminase, addition of two putative transition-

39 ng a link between EBV and activation-induced cytidine deaminase (AICDA) activity.

40 d functions in antibody diversification, the cytidine deaminase AID can catalyze off-target DNA damag

41 ription factors and Aicda (which encodes the cytidine deaminase AID) and thus silenced B cell-specifi

42 riven expression of AICDA (which encodes the cytidine deaminase AID), the immunoglobulin receptor CD2

43 nal pattern suggestive of activation-induced cytidine deaminase (AID) activity.

44 While both activation-induced cytidine deaminase (AID) and 53BP1 have been associated

45 on of the genomic mutator activation-induced cytidine deaminase (AID) and AID-dependent DNA double-st

46 ed to the Igh locus in an activation-induced cytidine deaminase (AID) and H2AX-dependent fashion.

47 Fs ectopically expressing activation-induced cytidine deaminase (AID) and observed an excess of AID s

48 n of DSBs is initiated by activation-induced cytidine deaminase (AID) and requires base excision repa

49 tudies have reported that activation-induced cytidine deaminase (AID) and ten-eleven-translocation (T

50 nt with the activities of activation-induced-cytidine deaminase (AID) and the A-T mutator, DNA polyme

51 The discovery of activation-induced cytidine deaminase (AID) and the use of murine models to

52 Conditional deletion of activation-induced cytidine deaminase (AID) between heterologous challenges

53 Activation-induced cytidine deaminase (AID) converts cytosine into uracil t

54 genome rearrangements via activation-induced cytidine deaminase (AID) followed by base excision repai

55 Activation-induced cytidine deaminase (AID) generates U:G mismatches in Ig

56 s studies have implicated activation-induced cytidine deaminase (AID) in B-cell translocations but ha

57 Endogenous activation-induced cytidine deaminase (AID) in engineered cells allowed for

58 Activation-induced cytidine deaminase (AID) initiates Ab class-switch recom

59 Activation-induced cytidine deaminase (AID) initiates both class switch rec

60 Activation-induced cytidine deaminase (AID) initiates both somatic hypermut

61 Activation-induced cytidine deaminase (AID) initiates class switch recombin

62 Activation-induced cytidine deaminase (AID) initiates CSR and SHM by deamin

63 Activation-induced cytidine deaminase (AID) initiates CSR by promoting deam

64 Activation-induced cytidine deaminase (AID) initiates DNA double-strand bre

65 Activation-induced cytidine deaminase (AID) initiates immunoglobulin (Ig) c

66 Activation-induced cytidine deaminase (AID) initiates immunoglobulin (Ig) h

67 The DNA deaminase activation-induced cytidine deaminase (AID) initiates somatic hypermutation

68 Activation-induced cytidine deaminase (AID) initiates somatic hypermutation

69 Activation-induced cytidine deaminase (AID) is a B-cell-specific enzyme tha

70 Activation-induced cytidine deaminase (AID) is a genome-mutating enzyme tha

71 Activation-induced cytidine deaminase (AID) is a key regulator of class swi

72 Activation-induced cytidine deaminase (AID) is a mutator enzyme that target

73 Activation-induced cytidine deaminase (AID) is critical in normal B cells t

74 Activation-induced cytidine deaminase (AID) is essential for class-switch r

75 PURPOSE OF REVIEW: Activation-induced cytidine deaminase (AID) is expressed in germinal center

76 Activation-induced cytidine deaminase (AID) mediates cytosine deamination a

77 tected GC B cells against activation-induced cytidine deaminase (AID) mutagenesis, facilitated cell c

78 B cells with constitutive activation-induced cytidine deaminase (AID) mutator activity.

79 The antibody gene mutator activation-induced cytidine deaminase (AID) promiscuously damages oncogenes

80 SH requires the activation-induced cytidine deaminase (AID) protein and transcription of th

81 The activation induced cytidine deaminase (AID) protein is known to initiate so

82 t targeting of the enzyme activation-induced cytidine deaminase (AID) results in the accumulation of

83 ion (CSR) is initiated by activation-induced cytidine deaminase (AID) that catalyzes numerous DNA cyt

84 Because CTNNBL1 binds activation-induced cytidine deaminase (AID) that catalyzes SHM, we tested A

85 In E. coli, we used activation-induced cytidine deaminase (AID) to construct AID-nCas9-Ung and

86 The ability of activation-induced cytidine deaminase (AID) to efficiently mediate class-sw

87 ul R loops, we used human activation-induced cytidine deaminase (AID) to identify genes preventing R

88 on-coupled recruitment of activation-induced cytidine deaminase (AID) to Ig switch regions (S regions

89 Precise targeting of activation-induced cytidine deaminase (AID) to immunoglobulin (Ig) loci pro

90 Likewise, recruitment of activation-induced cytidine deaminase (AID) to S regions is critical for CS

91 on-coupled recruitment of activation-induced cytidine deaminase (AID) to switch regions and by the su

92 ed with less targeting of activation-induced cytidine deaminase (AID) to the Igh locus.

93 ically inactive dCas9 to recruit variants of cytidine deaminase (AID) with MS2-modified sgRNAs, we ca

94 e we report the fusion of activation-induced cytidine deaminase (AID) with nuclease-inactive clustere

95 nes and activators induce activation-induced cytidine deaminase (AID)(2) and I-promoter transcription

96 the C-terminal region of activation-induced cytidine deaminase (AID), 14-3-3gamma targets this enzym

97 nal expansion and express activation-induced cytidine deaminase (AID), a DNA mutator.

98 the expression levels of activation-induced cytidine deaminase (AID), a key player in B-cell respons

99 , we apply this screen to activation-induced cytidine deaminase (AID), a poorly soluble protein that

100 RNA and protein levels of activation-induced cytidine deaminase (AID), a protein essential for SHM an

101 The Aicda gene encodes Activation-Induced cytidine Deaminase (AID), an enzyme essential for remode

102 e B cell specific enzyme, activation-induced cytidine deaminase (AID), and can be replicated in non-B

103 tion (SHM), which require activation-induced cytidine deaminase (AID), and plasma cell differentiatio

104 genes is initiated by the activation-induced cytidine deaminase (AID), and requires target gene trans

105 itch recombination (CSR), activation-induced cytidine deaminase (AID), and stability of E47 mRNA.

106 f that machinery, such as activation-induced cytidine deaminase (AID), as well as factors central to

107 s in AICDA, which encodes activation-induced cytidine deaminase (AID), display an impaired peripheral

108 eration and expression of activation-induced cytidine deaminase (AID), DNA repair enzymes, and post-c

109 DNA lesions initiated by activation-induced cytidine deaminase (AID), in the absence of mammalian-ty

110 ion (CSR) is initiated by activation-induced cytidine deaminase (AID), the activity of which leads to

111 These biomarkers are activation-induced cytidine deaminase (AID), the enzyme of class switch rec

112 Activation-induced cytidine deaminase (AID), the enzyme responsible for ind

113 Activation-induced cytidine deaminase (AID), the enzyme-mediating class-swi

114 Activation-induced cytidine deaminase (AID), which functions in antibody di

115 pathway, thereby inducing activation-induced cytidine deaminase (AID), which is critical for class sw

116 omes who are deficient in activation-induced cytidine deaminase (AID), which is required for class-sw

117 ng the DNA-editing enzyme activation-induced cytidine deaminase (AID), which is required in affinity

118 instability in B cells as activation-induced cytidine deaminase (AID), which mediates this process, i

119 +) B cells stimulated for activation-induced cytidine deaminase (AID)-dependent IgH class switch reco

120 eliberate introduction of activation-induced cytidine deaminase (AID)-instigated DNA double-strand br

121 B cells having undergone activation-induced cytidine deaminase (AID)-mediated somatic hypermutation

122 nsiently-expressed enzyme Activation-induced cytidine Deaminase (AID).

123 tations introduced by the activation-induced cytidine deaminase (AID).

124 of cytidine to uracil by activation-induced cytidine deaminase (AID).

125 he B-cell mutator protein activation-induced cytidine deaminase (AID).

126 of targeted DNA damage by activation-induced cytidine deaminase (AID).

127 geting of the DNA mutator activation-induced cytidine deaminase (AID).

128 on efficient induction of activation-induced cytidine deaminase (AID).

129 K 293 cells co-expressing activation-induced cytidine deaminase (AID).

130 genes is initiated by the activation-induced cytidine deaminase (AID).

131 itch regions and requires activation-induced cytidine deaminase (AID).

132 ntial activity of the DNA activation-induced cytidine deaminase (AID).

133 re, we have proposed that activation-induced cytidine deaminase (AID, encoded by AICDA) links chronic

134 ed CRISPR-Cas9 to disrupt activation-induced cytidine deaminase (AID; Aicda) directly in BXSB zygotes

135 The activation-induced cytidine deaminase (AID; also known as AICDA) enzyme is

136 ment through induction of activation-induced cytidine deaminase (AID; also known as AICDA) in precurs

137 ous and accessible DNMT1-targeted therapy is cytidine deaminase, an enzyme highly expressed in the in

138 editors (GBEs) consist of a Cas9 nickase, a cytidine deaminase and a uracil-DNA glycosylase (Ung).

139 in B mRNA-editing enzyme complex 1 (APOBEC1) cytidine deaminase and Deadend-1, which are involved in

140 found a synthetic lethal interaction between cytidine deaminase and microtubule-associated protein Ta

141 eamination of cytidine by activation-induced cytidine deaminase and subsequent DNA repair generates m

142 autoreactivity, expresses activation-induced cytidine deaminase and T-bet, and exhibits evidence of s

143 ivate NF-kappaB to induce activation-induced cytidine deaminase and, therefore, Ig class switch DNA r

144 indirect activation of DNA editing by APOBEC cytidine deaminases and of an endogenous clocklike mutat

145 Here we engineered programmable cytidine deaminases and test if we could introduce site-

146 dinated DNA demethylation pathway, utilizing cytidine deaminases and thymidine glycosylases, has been

147 in both the nematode Caenorhabditis elegans (cytidine deaminases) and its food (Escherichia coli); wh

148 formation, expression of activation-induced cytidine deaminase, and affinity maturation.

149 lly defective Streptococcus pyogenes Cas9, a cytidine deaminase, and an inhibitor of base excision re

150 llicular dendritic cells, activation-induced cytidine deaminase, and IL-21(+)PD1(+) follicular helper

151 in binds a zinc metal ion, as expected for a cytidine deaminase, and is potentially the catalytic com

152 oliferation, induction of activation-induced cytidine deaminase, and the production of circle and ger

153 zyme-catalytic, polypeptide-like 3 (APOBEC3) cytidine deaminases, and SAMHD1 (a cell cycle-regulated

154 edominant mutation signature associated with cytidine deaminase APOBEC, which correlates with the upr

155 more controversially, the activation-induced cytidine deaminase/APOBEC deaminases have the capacity t

156 In DART-seq, the cytidine deaminase APOBEC1 is fused to the m(6)A-binding

157 or model based on a mitochondrially-targeted cytidine deaminase, APOBEC1.

158 We found that two cytidine deaminases (apobec2a and apobec2b) were express

159 The human polydeoxynucleotide cytidine deaminases APOBEC3A, APOBEC3C, and APOBEC3H are

160 The APOBEC3 family comprises seven cytidine deaminases (APOBEC3A [A3A] to A3H), which are e

161 The catalytic activity of human cytidine deaminase APOBEC3B (A3B) has been correlated wi

162 We recently showed that the DNA cytidine deaminase APOBEC3B accounts for up to half of t

163 The single-stranded DNA (ssDNA) cytidine deaminase APOBEC3F (A3F) deaminates cytosine (C

164 Human cytidine deaminases APOBEC3F (A3F) and APOBEC3G (A3G) ar

165 Human cytidine deaminases APOBEC3F (A3F) and APOBEC3G (A3G) in

166 Functional analyses identified the cytidine deaminase APOBEC3G as a barrier for chimpanzee-

167 nfectivity factor (Vif) targets the cellular cytidine deaminases APOBEC3G (A3G) and APOBEC3F (A3F) fo

168 Here, we show that the related cytidine deaminase, APOBEC3G, induces site-specific C-to

169 The enzymatic reaction of cytidine deaminase appears to be a distinct example.

170 ls, lesions introduced by activation-induced cytidine deaminase are processed by multiple error-prone

171 es, uracils introduced by activation-induced cytidine deaminase are processed by uracil-DNA glycosyla

172 APOBEC3 cytidine deaminases are largely known for their innate i

173 Cytidine deaminases are single stranded DNA mutators div

174 vation with expression of activation-induced cytidine deaminase, as well as local differentiation of

175 ase-based CBE(7), and the Petromyzon marinus cytidine deaminase-based CBE Target-AID(4) induce less e

176 BEC3A-based CBE(6), human activation-induced cytidine deaminase-based CBE(7), and the Petromyzon mari

177 tion of U:G mismatches by activation-induced cytidine deaminase but differ in their subsequent mutage

178 The APOBEC3 family of cytidine deaminases cause lethal hypermutation of retrov

179 in such cells is attributed to a mycoplasma cytidine deaminase causing rapid drug catabolism.

180 APOBEC3G, a member of the double-domain cytidine deaminase (CD) APOBEC, binds RNA to package int

181 s and identified that L306 in the C-terminal cytidine deaminase (CD) domain contributed to its core l

182 Cytidine deaminase (CDA) binds the inhibitor zebularine

183 CYTIDINE DEAMINASE (CDA) catalyzes the deamination of cy

184 new possibilities for anti-cancer treatment.Cytidine deaminase (CDA) deficiency leads to genome inst

185 y bioavailable because of rapid clearance by cytidine deaminase (CDA) in the gut and liver.

186 (18)F-FAC tumor uptake is also influenced by cytidine deaminase (CDA), a determinant of resistance to

187 m revealed that TAMs induced upregulation of cytidine deaminase (CDA), the enzyme that metabolizes th

188 DNMT1 and tetrahydrouridine (THU) to inhibit cytidine deaminase (CDA), the enzyme that otherwise rapi

189 that the susceptible cell lines overexpress cytidine deaminase (CDA).

190 erivatives were synthesized as inhibitors of cytidine deaminase (CDA).

191 ions in the pyrimidine metabolic pathway and cytidine deaminase (CDA).

192 belongs to the AID/APOBEC protein family of cytidine deaminases (CDA) that bind to nucleic acids.

193 on of a long isoform of the bacterial enzyme cytidine deaminase (CDDL), seen primarily in Gammaproteo

194 V regions, expression of activation-induced cytidine deaminase, clonal H chain switch, and an invert

195 man APOBEC3 protein family of polynucleotide cytidine deaminases contributes to intracellular defense

196 c mice (quasimonoclonal, activation-induced [cytidine] deaminase-Cre-tamoxifen-dependent estrogen rec

197 identify genes enabling BLM-deficient and/or cytidine deaminase-deficient cells to tolerate constitut

198 Tau is overexpressed in cytidine deaminase-deficient cells, and its depletion wo

199 ere Tau functions in maintaining survival of cytidine deaminase-deficient cells, and ribosomal DNA tr

200 germline IgM produced in activation-induced cytidine deaminase-deficient mice (aicda(-/-)) provided

201 uracil N-glycosylase and activation-induced cytidine deaminase-deficient mice.

202 Igs and hypermutated IgM (activation-induced cytidine deaminase-deficient), or fully agammaglobulemic

203 ction factors that inhibit HIV-1 through DNA cytidine deaminase-dependent and -independent mechanisms

204 to mount dominant IgM and activation-induced cytidine deaminase-dependent IgG anti-FtL responses that

205 lated high frequencies of activation-induced cytidine deaminase-dependent IgH locus chromosomal break

206 Signatures of APOBEC cytidine deaminase DNA-editing exhibited substantial flu

207 nd that conserved catalytic residues in both cytidine deaminase domains are required for RNA editing.

208 e engineered base editors containing mutated cytidine deaminase domains that narrow the width of the

209 APOBEC3A is a cytidine deaminase driving mutagenesis, DNA replication

210 because a single enzyme, activation-induced cytidine deaminase (encoded by Aicda), initiates both re

211 CURE comprises the cytidine deaminase enzyme APOBEC3A fused to dCas13 and a

212 We engineered fusions of CRISPR/Cas9 and a cytidine deaminase enzyme that retain the ability to be

213 Several adenosine or cytidine deaminase enzymes deaminate transcript sequence

214 associated with increased activation-induced cytidine deaminase expression, and correlate with increa

215 ation ex vivo by altering activation-induced cytidine deaminase expression.

216 eaminase is unique within the zinc-dependent cytidine deaminase family as being allosterically regula

217 f these findings to the wider zinc-dependent cytidine deaminase family is also discussed.

218 polypeptide-like-3 (APOBEC3) innate cellular cytidine deaminase family, particularly APOBEC3F and APO

219 A3G is another member of the cytidine deaminases family predominantly expressed in ly

220 ons arise from the preference of APOBEC3A, a cytidine deaminase, for DNA stem-loops.

221 Using cytidine deaminase fused to Cas9 nickase, up to 28% of s

222 targeted mutagenesis in human cells using a cytidine deaminase fused to T7 RNA polymerase.

223 -mediated ablation of the activation-induced cytidine deaminase gene required for class switch recomb

224 pts and to upregulate the activation-induced cytidine deaminase gene through in vitro T-dependent and

225 show a frequent deletion polymorphism in the cytidine deaminases gene cluster APOBEC3 resulting in in

226 support functional GL7(+)/activation-induced cytidine deaminase(+) germinal centers.

227 ily of restriction factors, the APOBEC3 (A3) cytidine deaminases, has undergone positive selection an

228 oduction was dependent on activation-induced cytidine deaminase, hematopoietic MyD88 expression, and

229 s recently proposed for the APOBEC family of cytidine deaminases in generating particular genome-wide

230 tion, as it shows sequence similarities with cytidine deaminases in other organisms.

231 the miR-155 target Aicda (activation-induced cytidine deaminase) in this process and, in combination

232 n silico evidence have revealed that APOBEC3 cytidine-deaminases, including human APOBEC3G (hA3G), ca

233 The activation-induced cytidine deaminase-induced DNA lesions and error-prone r

234 3B activity, providing new insights into how cytidine deaminase-induced mutagenesis might be activate

235 NF-kappaB activation and activation-induced cytidine deaminase induction, and boosts IgG Ab and auto

236 dministration of tetrahydrouridine (a potent cytidine deaminase inhibitor).

237 ptide-like (APOBEC) proteins are a family of cytidine deaminases involved in various important biolog

238 n activated B cells where activation-induced cytidine deaminase is highly expressed.

239 However, a role for the APOBEC family of cytidine deaminases is proposed.

240 (PPR) protein SLO2, which lacks a C-terminal cytidine deaminase-like DYW domain, interacts in vivo wi

241 Here we investigate the fidelity of cytidine deaminase-mediated base editing in human induce

242 eoside transporters, and it was resistant to cytidine deaminase-mediated degradation.

243 SAMHD1 deficiency during activation-induced cytidine deaminase-mediated genomic instability.

244 ntrations of gemcitabine, synergizing with a cytidine deaminase-mediated mechanism of action.

245 ous, and likely caused by activation-induced cytidine deaminase-mediated somatic hypermutation, as sh

246 ACI antibody could induce activation-induced cytidine deaminase mRNA in those with mutations.

247 c antibody showed loss of activation-induced cytidine deaminase mRNA induction in all mutation-bearin

248 APOBEC cytidine deaminases mutate cancer genomes by converting

249 The APOBEC3 family of cytidine deaminases mutate the cancer genome in a range

250 In SHM, activation-induced cytidine deaminase mutates the V region of the Ig genes

251 f Cpf1 (Cas12a) and nCas9-activation-induced cytidine deaminase (nCas9-Target-AID) systems to mutagen

252 Several antiviral cytidine deaminases of the human APOBEC3 (hA3) family ha

253 ve DNA strand breakage at activation-induced cytidine deaminase off-target genes, its role at the hyp

254 drouridine (THU), a competitive inhibitor of cytidine deaminase, on the pharmacokinetics and pharmaco

255 Activation-induced cytidine deaminase, one of the APOBEC members, was repor

256 Because previously described cytidine deaminases operate on single-stranded nucleic a

257 We also tested CBEs with cytidine deaminases other than APOBEC1 and found that th

258 The APOBEC3 cytidine deaminases play a critical role in host-mediate

259 The activation-induced cytidine deaminase protein induces genome-wide DNA break

260 Inhibition of cytidine deaminase raised the levels of activated gemcit

261 enzyme, catalytic polypeptide-like (APOBEC) cytidine deaminases, raising questions about molecular m

262 report extensive computer simulations of the cytidine deaminase reaction and its temperature dependen

263 polypeptide-like 3 (APOBEC3 or A3) family of cytidine deaminases restrict viral infections by mutatin

264 Single-strand DNA-specific APOBEC cytidine deaminase(s) are major source(s) of mutation in

265 strate of some single strand-specific APOBEC cytidine deaminases, similar to the mutations that can t

266 reates a potent substrate for APOBEC3A (A3A) cytidine deaminase that can promote formation of mutatio

267 APOBEC3G (A3G) is a cytidine deaminase that catalyzes deamination of deoxycy

268 Human APOBEC3A (A3A) is a single-domain cytidine deaminase that converts deoxycytidine residues

269 Human APOBEC3H (A3H) is a cytidine deaminase that inhibits HIV-1 replication.

270 APOBEC3G (A3G) is a host cytidine deaminase that inhibits retroviruses.

271 downstream effector APOBEC3, an IFN-induced cytidine deaminase that introduces lethal mutations duri

272 APOBEC3G (A3G) is a cellular cytidine deaminase that restricts HIV-1 replication by i

273 APOBEC3G (A3G) is a cytidine deaminase that restricts human immunodeficiency

274 Human APOBEC3A is a single-stranded DNA cytidine deaminase that restricts viral pathogens and en

275 e catalytic subunit 3 (APOBEC-3) enzymes are cytidine deaminases that are broadly and constitutively

276 e earliest-diverged AID orthologs are active cytidine deaminases that exhibit unique substrate specif

277 The AID / APOBEC genes are a family of cytidine deaminases that have evolved in vertebrates, an

278 otein B editing complex 3 family members are cytidine deaminases that play important roles in intrins

279 c polypeptide 3 (APOBEC3) family members are cytidine deaminases that play important roles in intrins

280 uences rarely targeted by activation-induced cytidine deaminase, the enzyme responsible for antibody

281 ed with overexpression of activation-induced cytidine deaminase, the hotspot length increases even fu

282 We used a Cas9 nickase (nCas9)-cytidine deaminase to conduct C to T editing of the Ethy

283 t essential for targeting activation-induced cytidine deaminase to S regions, as was suggested.

284 ssibilities, we used a chemical inhibitor of cytidine deaminase to stabilize and thereby artificially

285 Base editing relies on recruitment of cytidine deaminases to introduce changes (rather than do

286 gs for cancer tissues presenting concomitant cytidine deaminase underexpression and Tau upregulation

287 int to TC motifs as activity hotspots of the cytidine deaminase used.

288 l DNA N-glycosylase (eUNG) and a rat APOBEC1 cytidine deaminase variant (R33A) previously shown to ha

289 Members of the APOBEC3 family of cytidine deaminases vary in their proportions of a virio

290 regulate transcription of activation-induced cytidine deaminase via Akt, repression of epsilonGLT and

291 ed genomic loci that are more susceptible to cytidine deaminase, we set up a high-throughput assay fo

292 signature attributed to the APOBEC family of cytidine deaminases, whereas others are confined to a si

293 APOBEC3B, an anti-viral cytidine deaminase which induces DNA mutations, has been

294 on (CSR) is instigated by activation-induced cytidine deaminase, which converts cytosines in switch r

295 ation (CSR) is induced by activation-induced cytidine deaminase, which initiates a cascade of events

296 t studies indicate that a subclass of APOBEC cytidine deaminases, which convert cytosine to uracil du

297 EC3 activity of Vif variants against several cytidine deaminases will help reveal the requirement for

298 sent the crystal structure of a complex of a cytidine deaminase with ssDNA bound in the active site a

299 APOBEC3G is a cytidine deaminase with two homologous domains and restr

300 or stromal remodeling and down-regulation of cytidine deaminase without depletion of tumor stromal co