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1 is also utilized in other enzymes, including cytochrome c oxidase.
2 (2+) centres of soluble guanylate cyclase or cytochrome c oxidase.
3 m by association of the bc1 complex with the cytochrome c oxidase.
4 e a biosynthesis and/or transfer to maturing cytochrome c oxidase.
5 ation by potently inhibiting the heme-copper cytochrome c oxidase.
6 tner of Cox17 in transferring copper ions to cytochrome c oxidase.
7 by the binuclear heme a3/CuB active site of cytochrome c oxidase.
8 talation of the Cu(B) center of subunit 1 of cytochrome c oxidase.
9 a toxin at high concentrations and inhibits cytochrome c oxidase.
10 ansfer in the IMS and thus for biogenesis of cytochrome c oxidase.
11 p372 as the location of this site in the ba3 cytochrome c oxidase.
12 preformed stores and reduced deactivation by cytochrome c oxidase.
13 on, if any, of reduced deactivation of NO by cytochrome c oxidase.
14 A recent example is provided by studies of cytochrome c oxidase.
15 itochondrial matrix for eventual assembly of cytochrome c oxidase.
16 plays an important role in the formation of cytochrome c oxidase.
17 within different MRC components upstream of cytochrome c oxidase.
18 tory activity caused by diminished levels of cytochrome c oxidase.
19 ancer because of its action on mitochondrial cytochrome c oxidase.
20 rget, COX2 mRNA, which encodes subunit II of cytochrome c oxidase.
21 enosine triphosphate (ATP) and a decrease in cytochrome c oxidase.
22 a more specific defect of respiratory chain cytochrome-c oxidase.
24 enase, pyruvate kinase, creatine kinase, and cytochrome c oxidase activities, and increased myoglobin
25 othesised a mechanistic relationship between cytochrome c oxidase activity and Cox7a1 protein levels
26 ction by measuring H2O2, lipid peroxidation, cytochrome c oxidase activity and mitochondrial ATP.
29 tein, have approximately 50-70% reduction in cytochrome c oxidase activity in all tissues yet a parad
31 s occur in mild hypoxia, where mitochondrial cytochrome c oxidase activity is unimpaired, suggesting
32 synthase activity was lower (P < 0.0001) and cytochrome c oxidase activity per Mt unit was higher (P
36 l density, mDNA/nDNA ratio), and functional (cytochrome c oxidase activity, ATP synthesis rate) marke
38 ned AMP-dependent kinase activation improved cytochrome c oxidase activity, rescued the motor phenoty
39 ator of mitochondrial bioenergetics enhanced cytochrome c oxidase activity, reversed oxidative stress
46 biopsies, cocoa improved mitochondrial COX (cytochrome c oxidase) activity (P=0.013), increased capi
47 ansport chain complexes) markers and COX IV (cytochrome C oxidase) activity in myocardium from patien
48 enzyme, is well expressed in neurons rich in cytochrome c oxidase, an important enzyme of the energy-
50 o terminal respiratory oxidases, an aa3-type cytochrome c oxidase and a cytochrome bd-type menaquinol
51 tected the activity of mitochondrial enzymes cytochrome c oxidase and aconitase in differentiating NS
54 e bc1 complex in the absence of a functional cytochrome c oxidase and identify a supercomplex indepen
56 degradation of hypohemylated Cox1 subunit of cytochrome c oxidase and is active in cytochrome c oxida
57 pression of ATP synthase's catalytic domain, cytochrome c oxidase and its tyrosine phosphorylation, m
59 y of the copper-binding mitochondrial enzyme cytochrome c oxidase and reduced ATP levels, despite enh
60 al fragment of Rcf2 associate with monomeric cytochrome c oxidase and respiratory chain supercomplexe
61 tochondrial fragmentation and a reduction of cytochrome c oxidase and succinate dehydrogenase activit
63 are structurally unrelated to mitochondrial cytochrome c oxidases and are therefore a prime target f
64 pressions of mediators of energy metabolism (cytochrome c oxidase) and mediators of neuronal activity
66 respiratory electron chain dependent on the cytochrome c oxidase, and this uncoupling induces the al
67 ease of the transcript abundance/activity of cytochrome-c-oxidase, and slower phycocyanin degradation
68 ated MT-CO2, the mtDNA-encoded subunit II of cytochrome c oxidase; and (3) reduced spare respiratory
69 llary-to-fiber ratio ( approximately 78.8%), cytochrome-c oxidase ( approximately 35%), and activity
70 biochemical deconvolution cascade suggested cytochrome c oxidase as the potential target of IPE clas
71 rome c oxidase activity was measured using a cytochrome c oxidase assay kit to monitor the health of
74 Our analyses show that Oms1 participates in cytochrome c oxidase assembly by stabilizing newly synth
75 present in the promoter of the mitochondrial cytochrome c oxidase assembly gene (SCO2), which is crit
76 dicate that KLF6-dependent regulation of the cytochrome c oxidase assembly gene is critical for maint
78 ets, iron-sulfur cluster scaffold (ISCU) and cytochrome c oxidase assembly protein (COX10), decreased
79 iron-sulfur assembly proteins)1/2 and COX10 (cytochrome c oxidase assembly protein-10), indicating en
80 he matrix side into the inner membrane while Cytochrome c oxidase assembly protein18 (Cox18/Oxa2) is
82 chain 3 (LC3) associated with mitochondrial (cytochrome c oxidase), autophagosome (p62), and autolyso
84 the COX1 mRNA is coupled to the assembly of cytochrome c oxidase by a mechanism that involves Mss51.
85 tion (oxygenated hemoglobin) and metabolism (cytochrome c oxidase) by 15% +/- 6.7% and 49% +/- 18%, r
86 Here, we identify the proposed cbb (3)-type cytochrome c oxidase (cbb (3)-Cox) assembly factor CcoG
87 latus, Cu-detoxification and Cu delivery for cytochrome c oxidase (cbb(3) -Cox) assembly depend on tw
88 pper importer CcoA, required for cbb(3)-type cytochrome c oxidase (cbb(3)-Cox) biogenesis, revealed a
89 y, we analyzed Cu delivery to the cbb3 -type cytochrome c oxidase (cbb3 -Cox) of Rhodobacter capsulat
91 res in the reduction of dioxygen to water by cytochrome c oxidase (CcO) are particularly important to
94 functional mimic of the mitochondrial enzyme cytochrome c oxidase (CcO) has been a long-term goal of
95 13-subunit integral membrane protein bovine cytochrome c oxidase (CcO) have been studied by differen
98 The synthesis of the heme a cofactor used in cytochrome c oxidase (CcO) is dependent on the sequentia
102 tional analyses have shown that bovine heart cytochrome c oxidase (CcO) pumps protons electrostatical
107 malfunction of multiple proteins, including cytochrome c oxidase (CcO), and Cu/Zn superoxide dismuta
109 T is assumed to rely on photon absorption by cytochrome c oxidase (CCO), the terminal enzyme in the m
111 o hemoglobin and by inhibiting mitochondrial cytochrome c oxidase (CcO), thereby decreasing oxygen de
121 nalysis revealed R25 to be the subunit II of cytochrome c oxidase (CCOX), an essential constituent of
124 dendritic mitochondria and histochemistry of cytochrome c oxidase (CO) activity were examined in pre-
126 tein p27 (Ldp27) is a component of an active cytochrome c oxidase complex in Leishmania donovani and
130 tide (reduced) dehydrogenase (complex I) and cytochrome c oxidase (complex IV) activity levels (immun
132 particular the cytochrome bc1 (complex III)-cytochrome c oxidase (complex IV) supercomplex (termed I
136 he terminal enzyme of the respiratory chain, cytochrome c oxidase, consists of a hydrophobic reaction
138 ression of key mitochondrial genes including cytochrome C oxidase copper chaperone (COX17) and ATP Sy
139 ociated with electron and proton transfer in cytochrome c oxidase could, in principle, be used to dis
140 present study, we found that the decrease in cytochrome c oxidase (COX) activity was ascribable to a
141 alized respiratory terminal oxidases (RTOs), cytochrome c oxidase (Cox) and cytochrome bd quinol oxid
142 ant decrease in the level of fully assembled cytochrome c oxidase (COX) and in its activity, suggesti
143 l oxidases: the thylakoid membrane-localized cytochrome c oxidase (COX) and quinol oxidase (Cyd) and
144 , suggesting an involvement in the CRC, with cytochrome c oxidase (COX) as a relevant protein complex
145 itochondrial protein with essential roles in cytochrome c oxidase (COX) assembly and the regulation o
147 frequently associated with cardiomyopathy is cytochrome c oxidase (COX) deficiency caused by mutation
150 llar cristae was associated with the gain of cytochrome c oxidase (COX) function, and the COX subunit
151 oxidase subunit 4 isoform 1 (Cox4i1) impair cytochrome C oxidase (COX) function, the multimeric enzy
152 -2-HG-mediated inhibition of the activity of cytochrome c oxidase (COX) in the mitochondrial electron
157 ng cox10 gene encoding an assembly factor of cytochrome c oxidase (COX) specifically in mouse ECs, pr
158 of this pathway involves phosphorylation of cytochrome c oxidase (COX) subunit 4-isoform 1 (COX4i1),
160 it shuttles electrons from bc(1) complex to cytochrome c oxidase (COX), and as a trigger of type II
164 sed mitochondrial iron loading and levels of cytochrome c oxidase (COX), which led to mitochondrial d
165 isorders from a range of 'large' and 'small' cytochrome c oxidase (COX)-deficient regions in skeletal
173 ults of histochemical analysis revealed that cytochrome-c oxidase (COX) deficiency was more evident i
175 I (NADH dehydrogenase, NDU) and complex IV (cytochrome-c-oxidase, COX) of the mitochondrial electron
181 th MICOS disassembly, abnormal cristae, mild cytochrome c oxidase defect, and sensitivity to glucose
184 ndividuals with mitochondrial complex IV (or cytochrome c oxidase) deficiency have mutations in the b
189 ions in individual muscle fibres with 20% of cytochrome c oxidase-deficient myofibres accumulating tw
191 tant lines impaired in the expression of the CYTOCHROME C OXIDASE DEFICIENT1 (COD1) gene, which encod
196 cluding impaired energy generation caused by cytochrome c oxidase dysfunction in the mitochondria.
197 osensor based on the bacterial expression of cytochrome c oxidase for the selective detection of clin
201 an 844 base pair region of the mitochondrial Cytochrome c oxidase gene, present at approximately 1 pp
202 elevated expression of several mitochondrial cytochrome C oxidase genes, suggesting increased aerobic
206 argeting short (127-314 bp) fragments of the cytochrome c oxidase I (CO1) DNA barcode region were dev
207 ochondrial DNA control region (mtDNA CR) and cytochrome c oxidase I (COI) gene from five populations
210 in expression of the mitochondrially encoded cytochrome C oxidase I (MTCO1), complex I activity, and
211 , extracted DNA and sequenced mitochondrial (cytochrome c oxidase I [mtCOI]) and nuclear (small subun
212 techniques based on two mitochondrial genes (cytochrome c oxidase I and 16S rRNA) we prove the existe
213 seq flowcell to obtain 658 base pairs of the cytochrome c oxidase I DNA barcode in 1,010 specimens fr
217 the available structures of ba(3)- and aa(3)-cytochrome c oxidases identifies possible active pathway
218 atomistic molecular dynamics simulations of cytochrome c oxidase in an explicit membrane-solvent env
219 binding of Na(+) and Ca(2+)cations to bovine cytochrome c oxidase in its fully oxidized and partially
221 tochondrial function that directly activates cytochrome c oxidase in the mitochondria and functions i
222 e a is an essential cofactor for function of cytochrome c oxidase in the mitochondrial electron trans
224 enzymes (P-450s, peroxidases, catalases, and cytochrome c oxidase) involved in biological respiration
225 on function (Q) of the redox center CuA from cytochrome c oxidase is attained by tuning the accessibi
226 on of the protonation rate at the surface of cytochrome c oxidase is found when the lipid area surrou
227 rmore, a reaction step that in the wild-type cytochrome c oxidase is linked to simultaneous proton up
232 te (Cu(A)) on subunit II (CoxB) of bacterial cytochrome c oxidase lie on the periplasmic side of the
234 ession of mitochondrial-encoded subunit 1 of cytochrome c oxidase (MTCO1), a subunit of respiratory c
237 atients, muscle biopsy showed ragged-red and cytochrome c oxidase-negative fibres with combined respi
238 nce of ragged-red fibers, however, scattered cytochrome c oxidase-negative staining and electron dens
239 ies of specific membrane proteins, including cytochrome c oxidase, NhaA Na(+)/H(+) exchanger, ClC-7 H
243 ong with a correlation between the number of cytochrome c oxidase operons and heterotrophic or diazot
245 his prediction measuring oxidation states of cytochrome c oxidase (oxCCO), an intracellular marker of
246 the oxidation state of mitochondrial enzyme cytochrome-c-oxidase (oxCCO) have the potential to yield
247 impressive results, a model of mitochondrial cytochrome c oxidase polypeptide I was obtained with a T
248 uptake in the Asn-139-Thr/Asp-132-Asn mutant cytochrome c oxidase, proton pumping was impaired, which
250 e to Zn(2+) addition, which in the wild-type cytochrome c oxidase slows the reaction, indicating that
252 unravel the use of the mitochondrial marker cytochrome c oxidase subunit 1 (coxI) as barcode for Lon
253 mitochondrial fraction indicates binding of cytochrome c oxidase subunit 1 (mt-COX1) mRNA from the m
254 in a stretch of 22 identical amino acids in cytochrome c oxidase subunit 1 and NADH dehydrogenase su
255 e KRIPP1 knockdown, A/U-tailed mRNA encoding cytochrome c oxidase subunit 1 declined concomitantly wi
256 nal assays, CB9032258 restored mitochondrial cytochrome c oxidase subunit 1 levels and rescued impair
259 TPR domain of OXA2b directly interacts with cytochrome c oxidase subunit 2, aiding in efficient memb
260 h the mitochondrial genes MT-CO2 and MT-CO3 (cytochrome c oxidase subunit 3); importantly, both enzym
262 he assembly of nuclear-encoded subunits like cytochrome c oxidase subunit 4 (Cox4) into the mature co
263 ow that the mitochondrial complex IV subunit cytochrome C oxidase subunit 4 (Cox4i1) is a direct TAp7
265 was to analyze the function of lung-specific cytochrome c oxidase subunit 4 isoform 2 (COX4i2) in vit
266 Complex III's Rieske Fe-S center and COX4i2 [cytochrome c oxidase subunit 4 isoform 2] in Complex IV)
268 in fragments of the mitochondrial (mt) genes cytochrome c oxidase subunit I (COI) and Cytochrome b as
270 S and of the main alternatively used marker [Cytochrome c oxidase subunit I (COI) mtDNA] belonging to
274 in the mtDNA [NADH dehydrogenase 6 (ND6) and cytochrome c oxidase subunit I (COI)] or nuclear DNA [ad
275 rtial sequence for the mitochondrial-encoded cytochrome c oxidase subunit I (Cox 1) gene in the cell
276 chondrial transcription factor-1 (Tfam), and cytochrome c oxidase subunit I (Cox-1) was determined by
277 translation-competent, long poly(AU)-tailed cytochrome c oxidase subunit I and edited apocytochrome
278 tures) over a 6-mo period were identified by cytochrome c oxidase subunit I barcoding (>2-mm mobile o
279 preferential inhibition of synthesis of the cytochrome c oxidase subunit I over apocytochrome b were
280 For the second objective, mitochondrial cytochrome c oxidase subunit I sequences of 16 individua
281 Here we used eDNA metabarcoding of COI (cytochrome c oxidase subunit I) and 18S (nuclear small s
285 EPAS1, and the nuclear-encoded mitochondrial cytochrome c oxidase subunit, COX4I2, in glomus cell sen
287 ption-factor-A (TFAM), mitochondrial-protein-cytochrome-C-oxidase subunit-2 (COX2), sirtuin-1 (SIRT1)
288 ntially affected, with near normal levels of cytochrome c oxidase subunit2 and Nad7 but little Nad6 p
289 ichiometric imbalance between mitochondrial (cytochrome c oxidase subunits 1 and 2) and nuclear (succ
292 vity of the mitochondrial respiratory chain (cytochrome c-oxidase/succinate dehydrogenase [COX/SDH]-r
293 ith a subpopulation of the cytochrome bc (1)-cytochrome c oxidase supercomplex and have been proposed
295 t the unusual sensitivity of skeletal muscle cytochrome c oxidase to sulfide poisoning in ethylmaloni
296 nstant approximately 65 mus in the wild-type cytochrome c oxidase) was impaired in the Asp372Ile vari
297 gly, yeast, mouse liver, and isolated bovine cytochrome c oxidase were directly inhibited by the drug
298 , whereas mice deficient in the synthesis of cytochrome c oxidase, which have reduced COX, were prote