ライフサイエンスコーパス: cytogenetically

1 ere later confirmed to have inv(16)/t(16;16) cytogenetically.

2 large effects on bristle number were mapped cytogenetically.

3 tants and virus-induced gene silencing lines cytogenetically.

4 Cytogenetically, a reduction in diploid chromosome numbe

5 xposures combined were possibly higher among cytogenetically abnormal 2.0 (95% confidence interval 0.

6 predictor of poor survival in patients with cytogenetically abnormal acute myeloid leukemia (CA-AML)

7 ssociated with favorable overall survival in cytogenetically abnormal AML (CA-AML) patients.

8 knowledge of exposure history, identified 75 cytogenetically abnormal and 139 normal (186 not studied

9 cals and radiation, the odds ratios for both cytogenetically abnormal and normal were marginally rais

10 Persistent cytogenetically abnormal cells at CR predict a significa

11 ure of these cells promoted the outgrowth of cytogenetically abnormal clones that, upon transplantati

12 matched controls were compared for 3 groups: cytogenetically abnormal, normal, and not known.

13 n that endothelial cells in solid tumors are cytogenetically abnormal.

14 Unexpectedly, tumor endothelial cells were cytogenetically abnormal.

15 e formation was particularly frequent in the cytogenetically adverse group, with subclone formation i

16 an independent adverse prognostic marker in cytogenetically adverse-risk AML.

17 Cytogenetically, all tumors are diploid or near diploid

18 This collection of cytogenetically anchored clones, representing nearly 7%

19 subset of chromosomal aberrations appearing cytogenetically and molecularly as simple terminal trunc

20 The dGCN2 gene was cytogenetically and physically mapped to the right arm o

21 are more frequent than previously recognized cytogenetically and that the deletions fall into four di

22 regions of chromosome 12 were characterized cytogenetically and were shown to have a normal compleme

23 particular type of recombination visualized cytogenetically as sister chromatid exchange (SCE), and

24 istinction that the t(X;17) translocation is cytogenetically balanced in these renal tumors.

25 In this study, we examined 237 cytogenetically characterized B-cell non-Hodgkin's lymph

26 Clear cell renal cell carcinoma (ccRCC) is cytogenetically characterized by chromosome 3p deletions

27 itially validated by analysis of a series of cytogenetically characterized cell lines, with the prese

28 marrow cells to trans-retinoic acid (RA) was cytogenetically characterized during RA treatment using

29 somal translocations, the mechanisms driving cytogenetically complex sarcomas are largely unknown.

30 Cytogenetically, complex > or = 5 predicted inferior dis

31 7, 2019, and July 27, 2021, 52 patients with cytogenetically confirmed synovial sarcoma (n=44) and my

32 A cytogenetically cryptic (12;21) translocation is the mos

33 d-end sequencing allowed identification of a cytogenetically cryptic event: a 77-kilobase segment fro

34 of orang-utans from other Great Apes, that a cytogenetically cryptic pericentric inversion may have b

35 Here, we contrasted the genomic landscape of cytogenetically defined aphidicolin-induced CFSs (aCFSs)

36 refined legitimate fragile sites within the cytogenetically defined boundaries, and identified poten

37 In addition to the cytogenetically defined direct insertion of material fro

38 ells similar to those found in patients with cytogenetically defined high-risk disease.

39 ltaneous gain of 1q21 and deletion of 17p in cytogenetically defined high-risk disease.

40 Key eligibility criteria included cytogenetically defined intermediate-risk AML according

41 We have placed 7,600 cytogenetically defined landmarks on the draft sequence

42 ubgroup analysis demonstrated that the three cytogenetically defined prognostic groups retained their

43 A cytogenetically defined region of the X chromosome, the

44 We demonstrate that the cytogenetically defined translocation t(X;1)(p11.2;p34)

45 was also found in 8 of 16 leiomyomas without cytogenetically detectable chromosome 6p21 aberrations b

46 rations of the protein product Patients with cytogenetically detectable deletions including JAG1 have

47 opies were found in individuals possessing a cytogenetically detectable elongation of the 15q region.

48 nts with loss of 5q, and 14 patients without cytogenetically detectable loss of 5q.

49 Although 8 of 9 MLL-AF4(+) infants had cytogenetically detectable t(4;11)(q21;q23), 15 of the 1

50 owever, between 30 and 50% of lymphomas with cytogenetically detectable translocations affecting band

51 ight cell lines, the deletions resulted from cytogenetically detectable whole chromosomal loss or lar

52 ic abnormalities considered as poor risk are cytogenetically detected chromosomal 13 or 13q deletion,

53 med a national cohort of 3425 women who were cytogenetically diagnosed with Turner syndrome in Great

54 Acute promyelocytic leukemia (APL), a cytogenetically distinct subtype of acute myeloid leukem

55 s paddlefish specific genome duplication are cytogenetically distinguishable.

56 , Oryzomyini) is a taxonomically complex and cytogenetically diverse genus with a controversial intra

57 ked proapoptotic activity against a panel of cytogenetically diverse primary human AML patient sample

58 in the PB plasma of all 45 patients who had cytogenetically documented chromosomal abnormalities (5q

59 ell lines also displayed significantly fewer cytogenetically evident alterations of chromosome struct

60 They have been recognized cytogenetically for more than a century(6), yet their or

61 ine miR-10 family expression in 54 untreated cytogenetically heterogeneous AML patients was associate

62 miR-182 expression as a prognostic marker in cytogenetically high-risk acute myeloid leukemia patient

63 show few changes over time, whereas those of cytogenetically high-risk patients show significantly mo

64 Survival in cytogenetically high-risk patients with acute myeloid le

65 tly within Asparagus and sex chromosomes are cytogenetically identical with the Y, harboring a megaba

66 We determined the prognostic significance of cytogenetically identified breakpoints in 13q12-14 in ch

67 A t(1;19)(q23;p13) is detected cytogenetically in approximately 5% of childhood acute l

68 ed FISH probes that can discriminate between cytogenetically indistinguishable chromosome homologues.

69 1(MUT) levels in 1609 younger adult cases of cytogenetically intermediate-risk AML.

70 esolution by sequencing 141 breakpoints from cytogenetically interpreted translocations and inversion

71 gative acute promyelocytic leukemia that had cytogenetically invisible insertions.

72 Whole-genome sequencing can identify cytogenetically invisible oncogenes in a clinically rele

73 2 gene (HGMW-approved symbol, TAGLN), and we cytogenetically localized the gene to chromosome 11q23.2

74 u hybridization were used to genetically and cytogenetically map AgMuc1 to division 7A of the right a

75 With 69 new FISH assignments, a total of 253 cytogenetically mapped loci physically anchor the RH map

76 related gene, p73, was recently isolated and cytogenetically mapped to chromosome region 1p36.

77 seemingly pure terminal deletions visualized cytogenetically may be more complex, and BFB cycles may

78 We evaluated the fragility of the block by cytogenetically measuring the distances between the flan

79 ormation, we have defined the breakpoints of cytogenetically monocentric and dicentric Xq isochromoso

80 Only one of the eight cytogenetically monocentric i(Xq)s demonstrated a single

81 No FRAXE expansion events were found in 362 cytogenetically negative males studied, and one expansio

82 in the context of other molecular markers in cytogenetically normal (CN) -acute myeloid leukemia (AML

83 ations in older patients (aged >/=60 y) with cytogenetically normal (CN) acute myeloid leukemia (AML)

84 Cytogenetically normal (CN) acute myeloid leukemia (AML)

85 uated in 238 adults aged 18 to 59 years with cytogenetically normal (CN) de novo acute myeloid leukem

86 prognostic mutations in older (>/= 60 years) cytogenetically normal (CN) patients with AML (n = 134).

87 /NSD1 was found in 15% of FLT3/ITD and 7% of cytogenetically normal (CN)-AML.

88 PM1 are the most frequently mutated genes in cytogenetically normal acute myeloid leukemia (AML), but

89 ents with myelodysplastic syndrome (MDS) and cytogenetically normal acute myeloid leukemia (AML).

90 ) mutations associate with a poor outcome in cytogenetically normal acute myeloid leukemia (AML).

91 duplication (PTD) associates with high-risk cytogenetically normal acute myeloid leukemia (AML).

92 ene-/microRNA-expression profiles in primary cytogenetically normal acute myeloid leukemia (CN-AML) a

93 e prognostic markers in younger (< 60 years) cytogenetically normal acute myeloid leukemia (CN-AML) a

94 mitantly affect the outcome of patients with cytogenetically normal acute myeloid leukemia (CN-AML) b

95 Pediatric cytogenetically normal acute myeloid leukemia (CN-AML) i

96 PARC was among the most upregulated genes in cytogenetically normal acute myeloid leukemia (CN-AML) p

97 n levels are associated with poor outcome in cytogenetically normal acute myeloid leukemia (CN-AML) p

98 rognostic significance of MAP7 expression in cytogenetically normal acute myeloid leukemia (CN-AML) p

99 ce of FLT3 D835/I836 mutations (FLT3-TKD) in cytogenetically normal acute myeloid leukemia (CN-AML) r

100 Cytogenetically normal acute myeloid leukemia (CN-AML) w

101 poietic stem cell transplantation (HSCT) for cytogenetically normal acute myeloid leukemia (CN-AML),

102 s favorable prognosis in younger adults with cytogenetically normal acute myeloid leukemia (CN-AML),

103 arker in adults aged < 60 years with primary cytogenetically normal acute myeloid leukemia (CN-AML),

104 nsidered an independent prognostic factor in cytogenetically normal acute myeloid leukemia (CN-AML),

105 ion was associated with improved outcomes in cytogenetically normal acute myeloid leukemia (CN-AML).

106 g isocitrate dehydrogenases in adult de novo cytogenetically normal acute myeloid leukemia (CN-AML).

107 umor 1 gene (WT1) mutations in younger adult cytogenetically normal acute myeloid leukemia (CN-AML).

108 ed gene- and microRNA-expression profiles in cytogenetically normal acute myeloid leukemia (CN-AML).

109 most frequent submicroscopic alterations in cytogenetically normal acute myeloid leukemia and to con

110 Molecular study of cytogenetically normal acute myeloid leukemia is among t

111 n signature previously suggested to separate cytogenetically normal acute myeloid leukemia patients i

112 e same normal karyotype, adults with de-novo cytogenetically normal acute myeloid leukemia who consti

113 ated with favorable outcome in patients with cytogenetically normal acute myeloid leukemia.

114 ically relevant molecular genetic studies of cytogenetically normal acute myeloid leukemia.

115 ion being the most common driver mutation in cytogenetically normal adult acute myeloid leukemia (AML

116 Cytogenetically normal AML (CN-AML) constitutes 40-50% o

117 nd found high LEF1 expression in a subset of cytogenetically normal AML (CN-AML) patients.

118 higher white blood cell counts (P < .0001), cytogenetically normal AML (CN-AML; P < .0001), NPM1 mut

119 rom adults under the age of 60 years who had cytogenetically normal AML and high-risk molecular featu

120 One feature of cytogenetically normal AML is alterations to the DNA met

121 signature in molecularly defined, high-risk, cytogenetically normal AML is associated with the clinic

122 a major impact on the clinical management of cytogenetically normal AML not only in prognostication b

123 Pretreatment blood samples from 84 cytogenetically normal AML patients aged less than 60 ye

124 and validation set (n = 105) of samples from cytogenetically normal AML patients from different popul

125 xpression signature that appears to separate cytogenetically normal AML patients into prognostic subg

126 to identify transforming genes expressed in cytogenetically normal AML patients.

127 t diagnosis correlated with poor survival in cytogenetically normal AML patients.

128 a genome-wide significant risk locus for the cytogenetically normal AML sub-group (N = 1287) at 6p21.

129 ion and cause perturbed enhancer activity in cytogenetically normal AML that contributes to a leukemi

130 ories, namely core-binding factor AML and/or cytogenetically normal AML, gene-expression and microRNA

131 al risk classifications in 214 patients with cytogenetically normal AML.

132 ting a frequency of 2.2% overall and 9.8% in cytogenetically normal AML.

133 =60 y) and younger (age <60 y) patients with cytogenetically normal AML.

134 profiling strategy for outcome prediction in cytogenetically normal AML.

135 Cells from 1 histologically and cytogenetically normal bronchial epithelial primary cult

136 Herein we show that in cytogenetically normal cases of AML and in cases with +1

137 nisms of leukemogenesis, we asked whether in cytogenetically normal cases one or both chromosomes car

138 act as a disease gene marker for these often cytogenetically normal disorders.

139 ocus for recurrent spontaneous abortion in a cytogenetically normal family.

140 lite DNA sequence variants, that distinguish cytogenetically normal homologous chromosomes by FISH.

141 er cell line and in telomerase immortalized, cytogenetically normal human breast epithelial cells usi

142 e 5 or 7 abnormalities) who achieved CR were cytogenetically normal in CR.

143 e observed when using a second cohort of 183 cytogenetically normal older (age >/= 60 years) AML pati

144 otypes had significantly worse outcomes than cytogenetically normal patients.

145 togenetic status; it was present in 13 of 80 cytogenetically normal samples (16%).

146 ly one of 124 patients reported initially as cytogenetically normal was ultimately RT-PCR-positive.

147 nge, 19 to 65 years), 29 patients (39%) were cytogenetically normal, and 11 (15%) had FLT-3 internal

148 f coverage (approximately 98%) of a primary, cytogenetically normal, de novo genome for AML with mini

149 a (AML), a large percentage of AML cases are cytogenetically normal.

150 The doubling time for patients relapsing cytogenetically or into chronic phase (median, 24.7 days

151 Thus, using the anti-inv(16) Ab, all cytogenetically positive and RT-PCR-positive AML cases w

152 detected in two related females known to be cytogenetically positive for a fragile site in Xq27.3-28

153 specifically detected all 23 cases that were cytogenetically positive for inv(16) or t(16;16), includ

154 duals have 6-35 copies of the repeat whereas cytogenetically positive, developmentally delayed males

155 have determined the extent of allele loss in cytogenetically prescreened MDS and AML patients for mic

156 PCL-like MM transcriptionally and cytogenetically resembled pPCL, but presented with signi

157 We investigate M-loci genomically and cytogenetically revealing distinct molecular architectur

158 sion event involving normal, nontransformed, cytogenetically stable epithelial cells can initiate chr

159 iploid, had normal centrosomes, and remained cytogenetically stable in culture even up to 20 passages

160 ous alpha satellite DNA, are mitotically and cytogenetically stable in the absence of selection for u

161 The genus Gymnotus is the most cytogenetically studied among the Gymnotiformes, having

162 ed in a blinded fashion to a series of eight cytogenetically t(2;5)-positive clinical specimens and s

163 wo groups, proteins are virtually identical, cytogenetically there are few rearrangements that distin

164 cence in situ hybridization, we map the gene cytogenetically to band 12q21.

165 jority of patients with 18q- syndrome appear cytogenetically to have a terminal deletion of the long

166 ) RRMM and VenDd with bortezomib (VenDVd) in cytogenetically unselected patients with RRMM.

167 his work) have been identified, analyzed and cytogenetically validated.

168 e-insert jumping libraries to delineate both cytogenetically visible and cryptic SVs in a single test

169 Subsequently, an interstitial, cytogenetically visible deletion in Xq25 was identified

170 Although sex chromosomes are not cytogenetically visible in this species, several lines o

171 Cytogenetically visible interstitial deletions involving

172 e sequencing (srGS) can only resolve ~70% of cytogenetically visible inversions referred to clinical

173 ed hemizygous deletions, consistent with the cytogenetically visible loss; no homozygous deletions we

174 Many cytogenetically visible, apparent terminal deletions are

175 f 12 with AML; six of these seven also had a cytogenetically-visible del(5q) or -5.

176 d variation in gene-expression patterns in a cytogenetically well-defined series of cell lines derive

177 to have its signature translocation defined cytogenetically, which led to the identification of its

178 on proximity to a gene that has been mapped cytogenetically, within band 3q13.31.