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1 city of Grsp1 complexes with Grp1, ARNO, and Cytohesin-1.
2 nd by phosphorylation of tandem PKC sites in Cytohesin-1.
3  mediated signaling of kinase Erk1/2 through cytohesin-1.
4 r an extra 3-base pair (GAG) exon present in cytohesin-1.
5 e critical for the specific interaction with cytohesin-1.
6 o-expressed with GRP1 or the related protein cytohesin-1.
7 139L decreased markedly the interaction with cytohesin-1.
8 guanine nucleotide exchange proteins such as cytohesin-1.
9 re to interact functionally with C-1 Sec7 or cytohesin-1.
10 ns the same structural components present in cytohesin -1, -2, and -3, including an approximately 200
11  were found in brain in different ratios for cytohesin-1, -2, and -3 but not cytohesin-4.
12 tative mass spectrometry to show that ARL4C, Cytohesin-1/3, and ARF6 accumulate in the RBX2 mutant te
13                                              Cytohesin-1, a 46-kDa ARF GEP, contains a central Sec7 d
14 sing the yeast two-hybrid system, a cDNA for cytohesin-1, a approximately 50-kDa protein with ARF gua
15                              Cybr also binds cytohesin-1, a guanine nucleotide exchange factor for th
16                                              Cytohesin-1, a protein abundant in cells of the immune s
17                                              Cytohesin-1 accelerated GTPgammaS (guanosine 5'-3-O-(thi
18  nonspecific ARF N terminus was required for cytohesin-1 action.
19 st that the Grsp1 heterodimers with Grp1 and Cytohesin-1 adopt a largely antiparallel orientation.
20                                              Cytohesin-1 also has been reported to promote cellular a
21                                              Cytohesin-1 also increased ARF1 binding to a Golgi fract
22 of single amino acids in the Sec7 domains of cytohesin-1 and -2 showed that residue 30 is critical fo
23 ide exchange factors for ARFs which includes cytohesin-1 and GRP-1 [2] [3-5].
24 tions, Grp1 and ARNO are homodimeric whereas Cytohesin-1 and Grsp1 are monomeric.
25                                              Cytohesin-1 and its 22-kDa Sec7 domain (C-1 Sec7), synth
26                                              Cytohesin-1 and its Sec7 domain (C-1Sec7) exhibit guanin
27                                     GRP1 and cytohesin-1 appear to connect receptor-activated PI 3-ki
28       GRP1 and the related proteins ARNO and cytohesin-1 are ARF exchange factors that contain a plec
29 p1 and Grp1 family proteins (Grp1, ARNO, and Cytohesin-1) as well as the oligomeric state, stoichiome
30                                              Cytohesin-1 (B2-1) is a guanine nucleotide exchange fact
31 NO (Arf nucleotide binding site opener), and Cytohesin-1 bind phosphatidylinositol (PtdIns) 3,4,5-tri
32 n this system, ARD1-GDP interacted well with cytohesin-1 but very poorly with cytohesin-2.
33                                In agreement, cytohesin-1, but not cytohesin-2, markedly accelerated [
34 nse to insulin, as were full-length GRP1 and cytohesin-1, but the PH domain of cytohesin-1 was not.
35 7 protein (ySec7d) and the insensitive human cytohesin-1 (C-1Sec7).
36                              Grp1, ARNO, and Cytohesin-1 comprise a family of phosphoinositide-depend
37  the Arf6 guanine nucleotide exchange factor cytohesin-1 controls Met-dependent cell migration.
38 sing an RNA interference screen, we identify cytohesin 1 (CYTH1) as a critical mediator of adhesive p
39 in, as opposed to the triglycine in ARNO and cytohesin-1, directs its remarkable PtdIns(3,4,5)P(3) bi
40                             Both C-1Sec7 and cytohesin-1 effectively released guanosine 5'-(gamma-thi
41                                              Cytohesin-1 enhanced binding of 35S-labeled guanosine 5'
42            Structures of the cytohesin-4 and cytohesin-1 genes were remarkably similar, except for an
43 inute-O-(thiotriphosphate) binding to ARF by cytohesin-1 in vitro was enhanced by Cybr.
44                                              Cytohesin-1, in addition to its role in cell adhesion, i
45                                              Cytohesin-1 increased [35S]guanosine 5'-(gamma-thio)trip
46                         Neither C-1 Sec7 nor cytohesin-1 increased GTPgammaS binding to human ARF-lik
47         Dominant negatives of both JAB-1 and cytohesin-1 inhibited interleukin 2 production and impai
48 s loss of DNA methylation enables HIF-driven cytohesin 1 interacting protein (CYTIP) expression to pr
49 n addition to the Sec7 domain is involved in cytohesin-1 interaction.
50                        It was concluded that cytohesin-1 is likely to be involved in ARD1 activation,
51 at selective phosphoinositide recognition by cytohesin-1 isoforms promotes distinct subcellular local
52                                              Cytohesin-1 isoforms, differing by the inclusion of an e
53 1 Sec7 was much less substrate-specific than cytohesin-1, it appears that structure outside of the Se
54   When mixed with Grsp1, Grp1 homodimers and Cytohesin-1 monomers spontaneously re-equilibrate to for
55 lished the ability to serve as substrate for cytohesin-1 or C-1Sec7.
56  participate in functional interactions with cytohesin-1 (or its catalytic domain C-1Sec7), which wer
57 onsistent with the previous observation that cytohesin-1 regulates the adhesiveness of alphaLbeta2 in
58 0 are also important in the interaction with cytohesin-1; replacement of Lys-38 with Gln, the corresp
59 , 1.6 and 1.0 micrometer for GRP1, ARNO, and cytohesin-1, respectively.
60   Structure-based mutational analysis of the cytohesin-1 Sec7 domain has been used to identify residu
61 ted, but it was much weaker than that of the cytohesin-1 Sec7 domain with the same ARF protein.
62 RF N terminus is an important determinant of cytohesin-1 specificity.
63 en ARF and Sec7-related proteins, effects of cytohesin-1, synthesized in Escherichia coli, on ARF act
64                                  Addition of cytohesin-1 to ARF3 with [35S]GTP[gammaS] bound, acceler
65 oth control cells and in response to GRP1 or cytohesin-1 was insensitive to brefeldin A, consistent w
66 on by the guanine nucleotide-exchange factor cytohesin-1 was known.
67 h GRP1 and cytohesin-1, but the PH domain of cytohesin-1 was not.
68 ndent on the coiled-coil domains of Cybr and cytohesin-1, was demonstrated by coimmunoprecipitation o
69 In contrast, another PI3K downstream target, cytohesin-1, was shown to mediate P. gingivalis fimbria-
70 ied activation of ADP ribosylation factor by cytohesin-1, we designate this cytokine-inducible protei
71       Recently, ARNO and its close homologue cytohesin-1 were found to catalyze in vitro nucleotide e
72 nsfected COS-7 cells, overexpressed ARD1 and cytohesin-1 were partially colocalized, as determined by
73 The solution structure of the Sec7 domain of cytohesin-1, which is responsible for both the protein's
74 The PH domain of the closely related protein cytohesin-1, which, through its Sec7 homology domain, re