ライフサイエンスコーパス: cytokine receptor

1 the T-cell receptor (TCR), co-receptors, and cytokine receptors.

2 and regulating the expression of epithelial cytokine receptors.

3 otein that mediates signalling from multiple cytokine receptors.

4 t sharing any structural similarity with the cytokine receptors.

5 rincipal transcription factors downstream of cytokine receptors.

6 onse through negative-feedback inhibition of cytokine receptors.

7 ell as aberrant activation of non-B lymphoid cytokine receptors.

8 s (JAKs) are regulators of signaling through cytokine receptors.

9 hain (gammac) is a key component of multiple cytokine receptors.

10 todomain shedding of cytokine precursors and cytokine receptors.

11 s model may well generalize to other class I cytokine receptors.

12 olecules, which impairs signaling of several cytokine receptors.

13 nt is present in the intracellular domain of cytokine receptors.

14 urgery to determine the presence of selected cytokine receptors.

15 through the B-cell receptor (BCR), CD40, and cytokine receptors.

16 tion of many type I and type II inflammatory cytokine receptors.

17 y regulates JAK family kinases downstream of cytokine receptors.

18 th targeted defects in specific cytokines or cytokine receptors.

19 gnature genes, including Rorc and activating cytokine receptors.

20 plays pivotal roles in signaling by several cytokine receptors.

21 effect on physiologic signaling by distinct cytokine receptors.

22 egulating NK ligands, adhesion molecules and cytokine receptors.

23 taining receptors, lymphocyte receptors, and cytokine receptors.

24 30, a common component of many heterodimeric cytokine receptors.

25 ell antigen receptors and common gamma chain cytokine receptors.

26 extracellular matrix remodeling enzymes, and cytokines/receptors.

27 ivation required the full pathway, including cytokine receptors acting as scaffolds and docking sites

28 echanistic blueprint for homodimeric class I cytokine receptor activation and its dysregulation by in

29 Cytokine receptor activation through loss of O-glycosyla

30 ion of mutual rotations of the TM domains in cytokine receptor activation.

31 it a STAT3-activating complex, circumventing cytokine receptor activation.

32 d elevated levels of the proosteoclastogenic cytokine receptor activator for nuclear factor-kappaB li

33 ogenesis in response to the osteoclastogenic cytokine receptor activator for nuclear factor-kappaB li

34 ng osteoclast differentiation induced by the cytokine receptor activator of NF-kappaB ligand (RANKL).

35 Production of the cytokine receptor activator of NFkappaB ligand (RANKL) b

36 The cytokine receptor activator of NFkappaB ligand (RANKL) p

37 ogen-associated molecular pattern receptors, cytokine receptors, adipokine receptors, and hormones.

38 gonists, antigen receptor cross-linking, and cytokine receptors, all rely on ubiquitination events to

39 Shedding of the extracellular domain of cytokine receptors allows the diffusion of soluble recep

40 Frequent mutations in cytokine receptor and Janus kinase (JAK)/signal transduc

41 netic alterations that activate constitutive cytokine receptor and kinase signaling, and early-phase

42 terized by genomic alterations that activate cytokine receptor and kinase signaling.

43 gh rates of mutations in factors involved in cytokine receptor and RAS signaling (62.2%), hematopoiet

44 by activating mutations in genes regulating cytokine receptor and RAS signalling (67% of cases; NRAS

45 expression of genes encoding key cytokines, cytokine receptors and adhesion molecules that determine

46 xperiments were performed to determine which cytokine receptors and cell types are involved in the pa

47 ontrolled by the integration of signals from cytokine receptors and germline-encoded activation and i

48 study, we considered the cooperation between cytokine receptors and integrin pathways in Th17-osteocl

49 at associates with the common gamma chain of cytokine receptors and is recurrently mutated in T-cell

50 latory cytokines uses the type I and type II cytokine receptors and pharmacological targeting of thes

51 etween high sequence conservation of TMDs of cytokine receptors and the ability to transmit structura

52 mplexes of the common gamma-chain (gamma(c)) cytokine receptors and their cytokines have been solved.

53 Aberrant signaling through cytokine receptors and their downstream signaling pathwa

54 erged that upregulated key memory-associated cytokine receptors and transcription factors and showed

55 lecular understanding of signaling biased by cytokine receptors, and demonstrate that manipulation of

56 mechanism whereby receptor tyrosine kinases, cytokine receptors, and integrins activate Src is not kn

57 receptors, toll-like receptors, inflammatory cytokine receptors, and mitogens.

58 ible for the transmission of the signal from cytokine receptors, and STAT2 is required for type I but

59 lly involve genes encoding tyrosine kinases, cytokine receptors, and transcription factors.

60 g signaling components of antigen receptor-, cytokine receptor-, and chemokine receptor-mediated sign

61 soluble cytokine receptor (sIL-2R), and one cytokine receptor antagonist (IL-1RA) were significantly

62 ntified a role for the IL-27p28 subunit as a cytokine receptor antagonist.

63 findings demonstrate that such specific anti-cytokine receptor antagonists represent a new class of d

64 CSF CRP in turn correlated with CSF cytokine receptors/antagonists (all p < 0.05).

65 Homodimeric class I cytokine receptors are assumed to exist as preformed dim

66 Pattern recognition receptors (PRRs) and cytokine receptors are key players in the initiation of

67 Soluble cytokine receptors are normal constituents of body fluid

68 eveals that genes for inflammatory cytokines/cytokine receptors are significantly altered upon change

69 ling for IFNgamma and other myelosuppressive cytokine receptors as a common mediator of signals for h

70 ular membrane proximal domain of homodimeric cytokine receptors as a key regulator of intracellular s

71 fferentiated NK cells with downregulation of cytokine receptors as early as 3 d after vaccination, su

72 ly upregulation of a number of cytokines and cytokine receptors, as key molecular components of an in

73 splayed elevated expression of cytokines and cytokine receptors, as well as neutrophil influx consist

74 illuminating the molecular basis of the JAK-cytokine receptor association.

75 Whether the ectodomains of cytokine receptors at the membrane exhibit different con

76 in B-ALL frequently mimic signalling through cytokine receptors at the pro-B-cell stage (via activati

77 Mutations in signaling molecules of the cytokine receptor axis play a central role in myeloproli

78 erent affinities to gp130 to investigate how cytokine receptor binding dwell-times influence function

79 ength and duration because of differences in cytokine-receptor binding affinity, receptor expression

80 ors, but it is unclear whether modulation of cytokine-receptor binding parameters can modify biologic

81 o calculate the rate constant of the initial cytokine-receptor binding to form a 1ratio1 complex.

82 r has served a pivotal role as the prototype cytokine receptor both structurally and functionally.

83 T cells encompass a variety of cytokines and cytokine receptors but are controlled by a 'guardian' tr

84 mediated directly via activation of neuronal cytokine receptors, but rather, indirectly via IL-1 rece

85 man single-pass TM proteins and validated in cytokine receptors by the TM domain structure of the cyt

86 on of the transcription factor T-bet and the cytokine receptor chain IL-12Rbeta2, which enabled the c

87 re combined immunodeficient mice lacking the cytokine receptor common gamma chain (gammac(-/-)) and c

88 receptors by the TM domain structure of the cytokine receptor common subunit beta and its P441A-subs

89 igenetic impairment of the tightly regulated cytokine-receptor communications in tumor microenvironme

90 tations are drivers of T-ALL and require the cytokine receptor complex for transformation.

91 JAK3 mutants needed to bind to a functional cytokine receptor complex to constitutively activate STA

92 Receptor activation involves a cytokine-receptor complex with a 1ratio2 stoichiometry.

93 ogether two different receptor subunits in a cytokine-receptor complex, precisely as the receptors ar

94 fferent receptor polypeptide to complete the cytokine-receptor complex.

95 Sharing of receptor subunits among different cytokine receptor complexes adds to the intricate landsc

96 s has impeded efforts aimed at crystallizing cytokine-receptor complexes.

97 hotspot gain-of-function mutation in myeloid cytokine receptor CSF2RB.

98 ed expression of the cytokine ANGPT2 and the cytokine receptor CXCR4 in colorectal cancer cells, whic

99 novel link between the ECM protein Matn4 and cytokine receptor CXCR4 involved in the regulation of HS

100 1 viral replication by selectively targeting cytokine receptor CXCR4.

101 Neutralisation of the IL-6 or IL-10 cytokine receptors dampened STAT3 phosphorylation and BC

102 Analysis of cytokine receptor deficient mice demonstrated that type

103 Using cytokine receptor-deficient mice, we show that interleuk

104 ling modulated STAT activation downstream of cytokine receptors differently to control the TH17 cell-

105 rigidification in the context of a liganded cytokine receptor dimer is a key mechanism for the trans

106 okines (synthekines) that drive formation of cytokine receptor dimer pairings that are not formed by

107 mode of cytokine action in which DL1 changes cytokine receptor distributions on hematopoietic cells,

108 ciation of the cytokine p28 with the soluble cytokine receptor EBV-induced gene 3 (EBI3).

109 Cytokine receptors elicit several signaling pathways, bu

110 stream effectors of the IFN-gamma and gammac cytokine receptors, eliminated the IFN signature and pre

111 ion, JAK2V617F, activates the 3 main myeloid cytokine receptors (erythropoietin receptor, granulocyte

112 is detected with a battery of type I and II cytokine receptors, except granulocyte colony-stimulatin

113 lt provides the first full view of a class I cytokine receptor, exemplifying the architecture of more

114 We therefore assessed the effects of EBI3 on cytokine receptor-expressing cells.

115 of Th2 cell differentiation by orchestrating cytokine receptor expression and cytokine responsiveness

116 L-12 and IL-18 correlated with the levels of cytokine receptor expression by NK and NKT cells.

117 Transcription factor-mediated regulation of cytokine receptor expression is a common mode of alterin

118 This was not due to downregulation of cytokine receptor expression or an inability to signal t

119 anscriptional profiles and altered chemokine/cytokine receptor expression patterns that interfered wi

120 TCR signal strength controlled downstream cytokine receptor expression, linking the two components

121 d that ORF54 can also target proteins of the cytokine receptor family and the mechanism of downregula

122 ceptor is an archetype member of the class I cytokine receptor family, comprising receptors with fund

123 ectin glycoprotein ligand-1 (PSGL-1, CD162), cytokine receptors, Fc receptors, integrins including al

124 g signal derived from pattern recognition or cytokine receptors, followed by a second signal derived

125 this study, we used mice in which the common cytokine receptor for IL-4 and IL-13, namely the IL-4Ral

126 matory marker myeloperoxidase (MPO), and the cytokine receptor for nuclear factor kappa-B ligand (RAN

127 Although there are dozens of cytokines and cytokine receptors, four Jaks, and seven Stats, it seems

128 Deletion of the gp130 cytokine receptor from sympathetic neurons prevented the

129 ukemogenesis: mutations in the hematopoietic cytokine receptor (G-CSFR) in combination with the secon

130 be activated via receptor tyrosine kinases, cytokine receptors, G-protein coupled receptors and liga

131 knockout mice in which IL-7Ralpha or common cytokine receptor gamma chain (gamma(c)) genes were dele

132 The common cytokine receptor gamma chain, gamma(c), is a component

133 IFNG, IL10, IL12B, IL18, IL1beta, IL8) and 1 cytokine receptor gene (IL12RB1).

134 a role for cytokine proteins and cytokine or cytokine receptor gene polymorphisms in smallpox vaccine

135 plored associations between SNPs in cytokine/cytokine receptor genes and cellular immunity in subject

136 fied, including four involving new kinase or cytokine receptor genes and seven involving new partners

137 ted by genetic polymorphisms in cytokine and cytokine receptor genes.

138 lls, caused by down-regulation of the common cytokine receptor, glycoprotein 130.

139 es such as TCR, costimulatory molecules, and cytokine receptors governs the magnitude of Akt activati

140 Disruption of the cytokine receptor gp130 gene in Muller glia reduces CNTF

141 pharmacological targeting of these cytokines/cytokines receptors has proven to be efficacious in trea

142 nstrate that impaired expression of a single cytokine receptor helps maintain Treg cell-suppressive f

143 We show that a wide range of non-natural cytokine receptor hetero-dimers are competent to elicit

144 22 signaling can be phenocopied by synthetic cytokine receptors, identified a functional IL-10R2 homo

145 ke receptor 9 (TLR9) along with inflammatory cytokine receptor IFN-gamma receptor (IFN-gammaR) as ess

146 17 cells in part by inhibiting expression of cytokine receptor IL-1R1.

147 ged approach of sustaining expression of the cytokine receptors IL-6Ralpha and gp130, enhancing expre

148 e gene programs, including expression of the cytokine receptors IL-6Ralpha and IL-7R.

149 ar to human MAITs, mouse MAITs expressed the cytokine receptors IL-7R, IL-18Ralpha, and IL-12Rbeta an

150 e gene upregulated by Cbfb-MYH11 encodes the cytokine receptor IL1RL1 (ST2).

151 he expression of Bcl6 and the TFH-associated cytokine receptor Il6ra Importantly, in vivo studies rev

152 Furthermore, LTA shapes the expression of cytokines, receptors, immune checkpoint ligands and adhe

153 Indeed, IL7R was the only cytokine receptor in CRLF2-rearranged B-ALL cells signif

154 rotein-coupled receptor, and a heterodimeric cytokine receptor in living cells with excellent sensiti

155 The thrombopoietin receptor, MPL, is the key cytokine receptor in MPN development, and these mutation

156 gp130, the signaling subunit of neuropoietic cytokine receptors in peripheral nerve regeneration.

157 The spatiotemporal organization of cytokine receptors in the plasma membrane is still debat

158 the dimerization of three prototypic class I cytokine receptors in the plasma membrane of living cell

159 egulated expression of several cytokines and cytokine receptors, including interleukin 15 receptor al

160 gulated by coordinated signals from multiple cytokine receptors, including KIT.

161 receptor tyrosine kinases or JAK-associated cytokine receptors, including leptin, insulin, growth ho

162 ed in expression of a panel of cytokines and cytokine receptors, including several ligand-receptor pa

163 The same cytokine receptor independence as for JAK3(L857P) was ob

164 he T cell antigen receptor (TCR) and certain cytokine receptors induce the expression of the RORgamma

165 Antibody blockade of cytokine receptors inhibited invasion and confirmed that

166 ogy and medicine, yet the mechanism by which cytokine receptors initiate signaling is enigmatic.

167 ion of functional clusters, such as cytokine-cytokine receptor interaction (especially CXC-chemokine)

168 evant to Immune reaction, including cytokine-cytokine receptor interaction (P = 4.61 x 10(-13)), chem

169 ups, enriched for genes involved in cytokine-cytokine receptor interaction and glutamate receptor sig

170 aconazole treatment, and identified cytokine-cytokine receptor interaction as the top significantly e

171 l signaling pathways, including the cytokine-cytokine receptor interaction pathway, which can promote

172 ithin the inflammatory response and cytokine-cytokine receptor interaction pathways, including Csf1 a

173 enes involved in cytokine activity, cytokine-cytokine receptor interaction, chemokine activity, and G

174 rotein kinase-B) signaling pathway, cytokine-cytokine receptor interaction, extracellular matrix (ECM

175 cluded chemokine signaling pathway, cytokine-cytokine receptor interaction, oxidative phosphorylation

176 Shared DEGs were enriched for cytokine-cytokine receptor interaction.

177 Knowledge of cytokine-receptor interaction (CRI) is very important fo

178 genes encoding proteins involved in cytokine-cytokine receptor interactions and NK cell-mediated cyto

179 ith PFS more than 6 months included cytokine-cytokine receptor interactions, drug transporters, and m

180 o TF motifs TEAD1 and JUN to induce cytokine-cytokine receptor interactions.

181 nderstanding of the structural principles of cytokine-receptor interactions has advanced, mechanism-b

182 ies to common gamma cytokines, inhibitors of cytokine-receptor interactions, and JAK kinase inhibitor

183 pable of activating beta common chain family cytokine receptor (interleukin-3 receptor [IL-3R], IL-5R

184 n levels, physiological cytokine levels, and cytokine-receptor intracellular trafficking kinetics.

185 e 2 (TYK2) participates in signaling through cytokine receptors involved in immune responses and infl

186 Signalling in lymphocytes through cytokine receptors is critical for their development, ac

187 Insight in the complex formation of cytokine receptors is crucially important for engineerin

188 A hallmark of the class I cytokine receptors is the class I cytokine receptor sign

189 eukemia virus (MPL), abnormally activate the cytokine receptor/JAK2 pathway and their downstream effe

190 ell-cycle regulation, and tumor suppression; cytokine receptor, kinase, and Ras signaling; and chroma

191 that commonly perturb lymphoid development, cytokine receptors, kinase and Ras signaling, tumor supp

192 e marrow chimeras, we compared wild-type and cytokine receptor knockout CD8(+) T cells within the sam

193 aling events and show that relatively simple cytokine receptors like GHRs are able to form higher ord

194 Cytokine receptor-like factor 1 (CRLF1) was among the mo

195 This gene set includes cytokine receptor-like factor 1 (CRLF1), which is up-reg

196 D) in interleukin-7 receptor alpha (IL7R) or cytokine receptor-like factor 2 (CRLF2) have been descri

197 Within the Ph-like ALL cohort, 61% had cytokine receptor-like factor 2 (CRLF2) overexpression.

198 rrangements of the cytokine receptor subunit cytokine receptor-like factor 2 (CRLF2), and other tumor

199 lisib resulted in near eradication of ALL in cytokine receptor-like factor 2 (CRLF2)/JAK-mutant model

200 is insufficient to eradicate the most common cytokine receptor-like factor 2-rearranged (CRLF2-rearra

201 Hence, type I cytokine receptors may be activated in leukemia through

202 ic neurodegeneration may be accelerated by a cytokine-receptor mediated apoptotic pathway, as shown i

203 stem cell (HSC) homeostasis is controlled by cytokine receptor-mediated Janus kinase 2 (JAK2) signali

204 impaired ability to secrete IFN-gamma during cytokine receptor-mediated responses, whereas immunorece

205 ponents that mediate B cell receptor- and or cytokine receptor-mediated signaling to promote the diff

206 T1E28z is coexpressed with a chimeric cytokine receptor named 4alphabeta (combination termed T

207 T1E28z was coexpressed with a chimeric cytokine receptor named 4alphabeta (combination termed T

208 nd/or environmental cues and act via cognate cytokine receptors on target cells, stimulating specific

209 genes important in homeostatic regulation of cytokine receptors or TLR-mediated signal transduction p

210 Here, we identified the cytokine receptor OSMR as a direct target gene of the tr

211 Thus, our work has identified a cytokine-receptor pair with important function in regula

212 rent study, we investigated the role of this cytokine/receptor pair in acute intestinal injury/repair

213 transcription factors, metabolic genes, and cytokine/receptor pairs.

214 We show here that, unlike other cytokine receptors, phosphorylation of STRA6 is not simp

215 ck of efficacy, either of which results from cytokine receptor pleiotropy and/or undesired activation

216 To test the hypothesis that serum cytokines/cytokine receptors provide prognostic information in the

217 Cytokine receptors receive extracellular cues by binding

218 nd most transcription factors, cytokines and cytokine receptors related to the CD4 lineage, despite t

219 This different cytokine receptor requirement correlated with different

220 Genetic ablation of individual cytokine receptors revealed that both IFN-gamma and IL-1

221 Alterations in cytokine receptor signal transduction have emerged as on

222 ine phosphatase SHP2, which is essential for cytokine receptor signaling (including FLT3), by the sma

223 transcription 5) is an essential mediator of cytokine receptor signaling and plays important roles in

224 s by which TCR signaling and proinflammatory cytokine receptor signaling cooperate in these processes

225 lterations that lead to activated kinase and cytokine receptor signaling in Ph-like ALL and demonstra

226 Our data suggest that cytokine receptor signaling is required for tumor cell s

227 We present a strategy to modulate cytokine receptor signaling output by use of a series of

228 The evolution of cytokine receptor signaling parallels that of the immune

229 t genes encoding proteins involved in Ag and cytokine receptor signaling pathways including PTPN22 an

230 he inhibitory effects were downstream of TH2 cytokine receptor signaling pathways.

231 We focus on cytokine receptor signaling that is mimicked by activati

232 oss-functional negative regulator of TLR and cytokine receptor signaling via degradation of the recep

233 This review describes the evolution of cytokine receptor signaling, focusing on the class I and

234 included IL-1R/TLR signaling, type I and II cytokine receptor signaling, mitochondrial dysfunction,

235 a mutated chaperone constitutively activates cytokine receptor signaling.

236 by which the extracellular matrix regulates cytokine receptor signaling.

237 ldren initiated by mutations that deregulate cytokine receptor signaling.

238 CS) proteins serve as negative regulators of cytokine receptor signaling.

239 genomic alterations that activate kinase and cytokine receptor signaling.

240 s shared with conventional costimulatory and cytokine receptor signaling.

241 Genes for chemokines, cytokine receptors, signaling molecules, complement, and

242 ed beta2-integrin tail interactions restrict cytokine receptor signalling, survival, maturation and m

243 Lymphocytes integrate Ag and cytokine receptor signals to make cell fate decisions.

244 he class I cytokine receptors is the class I cytokine receptor signature motif (WSXWS).

245 rosis factor-alpha (TNF-alpha)), one soluble cytokine receptor (sIL-2R), and one cytokine receptor an

246 expression or an inability to signal through cytokine receptors since phosphorylation of STAT protein

247 enalidomide on receptor turnover were Type I cytokine receptor specific, as evidenced by coregulation

248 IL-2Rbeta induce marked subunit- and soluble cytokine receptor-specific behavioral disturbances, whic

249 hoblastic leukemias (B-ALLs) overexpress the cytokine receptor subunit CRLF2, which may confer a poor

250 leukemia (B-ALL) with rearrangements of the cytokine receptor subunit cytokine receptor-like factor

251 mutations in the common gamma (gammac) chain cytokine receptor subunit give rise to severe combined i

252 Using multiple cytokine and cytokine receptor subunit knockout mice, we demonstrate

253 ry factor (LIF), signal via the common GP130 cytokine receptor subunit.

254 y all TLRs, RLRs and IL-1R, as well as other cytokine receptors such as IL-18 receptor.

255 yrosine kinases associate with heterodimeric cytokine receptors such as IL-7 receptor or IL-9 recepto

256 eceptors (RLRs; RIG-I and MDA-5), as well as cytokine receptors such as interleukin 1 receptor (IL-1R

257 ne receptors such as Toll-like receptors and cytokine receptors such as those in the TNF (tumor necro

258 -inflammatory, highly relevant cytokines and cytokine receptors, such as IL-4Ralpha, IL-13, IL-31, an

259 sociate with a functional homodimeric type I cytokine receptor, suggesting that, although acquiring J

260 lso demonstrated in mRNAs encoding six other cytokine receptors, suggesting a novel mode through whic

261 in receptor (PRLR), which is a member of the cytokine receptor superfamily that signals via Janus kin

262 Recently, we have designed synthetic cytokine receptors (SyCyRs) consisting of GFP and mCherr

263 io2 native complex are similar for the three cytokine-receptor systems.

264 canonical TGF-beta signaling mediated by the cytokine receptor TGFbetaR1 in NK cells.

265 or-inducible 14 (Fn14) is a highly inducible cytokine receptor that engages multiple intracellular si

266 rally occurring splice isoform of the gammac cytokine receptor that is produced by activated T cells

267 1 receptor alpha (IL-31RA) is a novel Type I cytokine receptor that pairs with oncostatin M receptor

268 The PRL receptor (PRLR) is a class I cytokine receptor that signals via the Janus kinase (JAK

269 l from RBP into cells, and it functions as a cytokine receptor that, on binding holo-RBP, activates J

270 llular RBP into cells, and it functions as a cytokine receptor that, upon binding holo-RBP, triggers

271 eins are a family of inducible inhibitors of cytokine receptors that activate the JAK-STAT pathway.

272 ation involves a persistent loss of specific cytokine receptors that determines the functional potent

273 cell memory by modulating the expression of cytokine receptors that influence the differentiation an

274 o transmembrane and intracellular domains of cytokine receptors that phenocopy cytokine signaling ind

275 anus kinase (JAK) inhibitors have shown that cytokine receptors that signal through the JAK/STAT sign

276 late expression on memory precursor cells of cytokine receptors that support terminal differentiation

277 receptor-bound JAK2, based on an archetypal cytokine receptor, the growth hormone receptor.

278 Common to both cytokine receptors, the IL-2 receptor beta (IL2Rbeta) ch

279 minor effects, and in the presence of type I cytokine receptors, the mutations do not affect JAK2 act

280 iously, we reported an agonist antibody to a cytokine receptor, Thrombopoietin receptor (TPOR) that e

281 via Toll-like Receptor (TLR) and TNF-family cytokine receptor (TNFR) signaling pathways.

282 that the signaling pathways triggered by the cytokine receptor TNFR1 play a more significant role in

283 recognition receptor TLR2- and inflammatory cytokine receptor TNFR1-mediated signaling pathways.

284 rmore, we describe the molecular switch from cytokine receptor to pre-BCR signaling, how this pathway

285 not require an exogenous homodimeric type 1 cytokine receptor to transform Ba/F3 cells and is capabl

286 eceptor as an archetype model of homodimeric cytokine receptors to address the role of the extracellu

287 ignals from Ag, costimulatory receptors, and cytokine receptors to control cell division, differentia

288 ijacked cellular genes encoding cytokines or cytokine receptors to disrupt host cell communication.

289 ferentiation by modulating the expression of cytokine receptors to help specify and maintain differen

290 D interacts with the intracellular domain of cytokine receptors to regulate their signaling output in

291 To assess the contribution of cytokine receptors to the differentiation of T cell subs

292 endent roles of ATG16L1 in the regulation of cytokine receptor trafficking and signaling, and provide

293 further revealed significant differences in cytokine receptor transcript levels (including IL-22RA1

294 delicate, intracellular feedback loop among cytokine receptors, transcription factors and miRNAs.

295 pairs Stat3 responses downstream of multiple cytokine receptors via selective, posttranscriptional su

296 We found that cytokines and cytokine receptors were the dominant class of genes exhi

297 (RBP) into cells, and it also functions as a cytokine receptor which activates JAK/STAT signaling.

298 lecules mediate their effects through type 1 cytokine receptors, which bind cytokines with a characte

299 ranscription-factors (T-bet and Blimp-1) and cytokine receptors while paradoxically repressing genes

300 synthekine ligands that dimerized a JAK/STAT cytokine receptor with a receptor tyrosine kinase (RTK)