ライフサイエンスコーパス: cytolytic

1 of gamma-secretase inhibitor, the antitumor cytolytic ability of gammadelta T cells was inhibited wi

2 Here we show that long after their peak in cytolytic activation, NK cells continue to support viral

3 s LukSF-PV and LukED antagonize each other's cytolytic activities on leukocytes and erythrocytes by f

4 ells are innate immune cells known for their cytolytic activities toward tumors and infections.

5 ent proinflammatory and receptor-independent cytolytic activities.

6 y, mainly through rapid cytokine release and cytolytic activities.

7 rom higher heterogeneous tumors showed lower cytolytic activities.

8 t study, we analyzed PD-L1, PD-L2, PD-1, and cytolytic activity (CYT) expression, as well as mutation

9 ive Cancer Genome Atlas (TCGA) samples where cytolytic activity (CYT) imparts a known survival benefi

10 tes produced negligible IFN-gamma and lacked cytolytic activity against leukemia cells.

11 ased proliferation, cytokine production, and cytolytic activity against melanoma cells.

12 nes repolarized TAMs, resulting in recovered cytolytic activity and antitumoral capacity of NK cells

13 he NK and target cells but decreased NK cell cytolytic activity and degranulation.

14 exhibited cholesterol-dependent binding and cytolytic activity and formed the typical large CDC memb

15 positively associated with genes related to cytolytic activity and immune checkpoints.

16 aracterized by reduced markers of anti-tumor cytolytic activity and lower major histocompatibility co

17 st virus infections and cancer through their cytolytic activity and production of cytokines.

18 in the absence of AhR, NK cells have reduced cytolytic activity and reduced capacity to control RMA-S

19 I-associated neoantigens was correlated with cytolytic activity and was lower than expected in colore

20 Cytolytic activity by CD8(+) cytotoxic T lymphocytes (CT

21 the effector cells regulate the kinetics of cytolytic activity by the effector cells.

22 proinflammatory cytokines and do not display cytolytic activity characteristic of effector CD8(+) T c

23 ytotoxicity receptor (NCR)-dependent NK-cell cytolytic activity directed at HCV-infected and uninfect

24 healthy donor and HCV-infected donor NK-cell cytolytic activity directed at HCV-infected target cells

25 d to bind mouse CD11b-I, we demonstrate that cytolytic activity does not only require binding but als

26 ector memory phenotype, and present a strong cytolytic activity ex vivo.

27 T cell compartment led to markedly increased cytolytic activity following an allogeneic MLR in vitro,

28 ed than uninfected cells, the selectivity of cytolytic activity for infected targets was lower during

29 erferon-gamma signalling, and correlate with cytolytic activity in patient tumours from The Cancer Ge

30 o pro-cancerous immune cells and immune cell cytolytic activity in primary BC was associated with lat

31 ived from patients with MS exhibit a reduced cytolytic activity in response to antigen-activated CD4(

32 ells that can induce cytokine production and cytolytic activity in resting NK cells.

33 ls demonstrated high IFNgamma production and cytolytic activity in vitro Upon systemic administration

34 PVL and LukGH have potent cytolytic activity in vitro, and both toxins are proinfl

35 trate that AMG 330 has potent CD33-dependent cytolytic activity in vitro, which can be further enhanc

36 Later, in vivo cytolytic activity is detectable, coincident with the in

37 netics of granule delivery and efficiency of cytolytic activity is not well understood.

38 rease in NCR expression and IL28B-associated cytolytic activity may participate in host response to I

39 of the integrin receptor ligation may alter cytolytic activity of CD16.NK-92 cells, we analyzed mole

40 exhibited severely reduced degranulation and cytolytic activity of CTL and NK cells and developed all

41 e intrinsic resistance of tumor cells to the cytolytic activity of immune effectors.

42 The cytolytic activity of Mamu-KIR3DL01(+) NK cells was supp

43 XBP1s positively regulated the cytolytic activity of NK cells against leukemia cells an

44 ply that STAT3 inhibitors will stimulate the cytolytic activity of NK cells against leukemia, thereby

45 n of CD155-expressing CD4(+) T cells and the cytolytic activity of NK cells.

46 (IL-15) and IL-2 in inducing activation and cytolytic activity of NK cells.

47 causes defective degranulation and impaired cytolytic activity of T and NK cells.

48 lid tissue tumor biopsies, we quantified the cytolytic activity of the local immune infiltrate and id

49 ecule, Mamu-B*017:01, failed to suppress the cytolytic activity of these NK cells.

50 Membrane cholesterol is required for the cytolytic activity of this toxin, but it is not clear wh

51 l recruitment and occurred instead by direct cytolytic activity on free stages of the parasite.

52 fic CD8+ T cell-mediated IL-10 production or cytolytic activity or Foxp3+ regulatory T cell populatio

53 Additionally, T-cell receptor diversity, cytolytic activity score (CYT), and T-cell exhaustion ma

54 In agreement, cytolytic activity score that assesses immune cell cytol

55 T-cell cytolytic activity targeting epidermal melanocytes is sh

56 engineered IL-10 variant displayed superior cytolytic activity than those expanded with wild-type IL

57 emains unclear whether, in addition to their cytolytic activity that is important in antimicrobial de

58 ion-induced cell death and mediates specific cytolytic activity toward autologous tumor cells upon bl

59 n and most importantly NMD burdens influence cytolytic activity using machine learning models and sur

60 Furthermore, cytolytic activity was associated with higher serum aspa

61 were CD4 T cells, not CD8 T cells, and this cytolytic activity was not dependent on granzyme A/B or

62 Enhanced cytolytic activity was observed for CD8(+) T cells cocul

63 tic activity score that assesses immune cell cytolytic activity was significantly lower in Late compa

64 Ts harbored more immune cells with increased cytolytic activity when compared to KIT-mutant GISTs.

65 based fitness and tumor T-cell infiltration, cytolytic activity, and abundance (tumor infiltrating ly

66 d 1) and programmed cell death 1, markers of cytolytic activity, and fewer chromosomal aberrations.

67 on of PTEN in NK cells resulted in decreased cytolytic activity, and loss of PTEN in CD56(bright) NK

68 T cells and NK cells exhibited impaired cytolytic activity, and mice infected with mouse cytomeg

69 APOBEC-mediated mutagenesis, upregulation of cytolytic activity, and PD-L1 positivity.

70 sed IFNgamma expression, indicating enhanced cytolytic activity, as well as decreased expression of e

71 pecific CD4 T cell functions, such as direct cytolytic activity, can contribute to control of HIV vir

72 genes that showed positive association with cytolytic activity, including beta-2-microglobulin (B2M)

73 mplifications were also associated with high cytolytic activity, including immunosuppressive factors

74 Our findings suggest that despite its cytolytic activity, pneumolysin serves as a potent neutr

75 r profile of cytokines but displayed greater cytolytic activity, secreting perforin, granzyme B, and

76 ceptors (CAR) T cells demonstrating specific cytolytic activity.

77 , production of intracellular cytokines, and cytolytic activity.

78 ma (IFN-gamma), but not by granzyme-mediated cytolytic activity.

79 ability, proliferation, and antigen-specific cytolytic activity.

80 n CD56(bright) NK cells resulted in elevated cytolytic activity.

81 apoptosis as key strategies of resistance to cytolytic activity.

82 hese cells have direct ex vivo DENV-specific cytolytic activity.

83 mechanisms of tumor-intrinsic resistance to cytolytic activity.

84 xpansion and allow the acquisition of robust cytolytic activity.

85 hat CD8(+) T cells produce cytokine and have cytolytic activity.

86 transcriptional activity, proliferation, and cytolytic activity.

87 nificant and independent predictor of immune cytolytic activity.

88 ly proliferate, transcribe IFNgamma and show cytolytic activity.

89 z CAR T cells, although they retained potent cytolytic activity.

90 eta treatment of NK cells rendered them less cytolytic against oHSV-infected glioblastoma cells and s

91 hile HCV-specific CD8 T-cell activation with cytolytic and antiviral effects was blunted by PD-L1 exp

92 P2X7 receptor channel (P2X7R) operates as a cytolytic and apoptotic receptor but also controls susta

93 f NK cells shows a significant impairment of cytolytic and degranulation activities in patients with

94 mids or the genome had significantly reduced cytolytic and pro-inflammatory capacities, including in

95 N-AgrD displays cytolytic and proinflammatory properties that are abroga

96 ubstitution library of PSMalpha3, a strongly cytolytic and proinflammatory PSM of Staphylococcus aure

97 Antimicrobial, cytolytic, and cell-penetrating peptides induce pores or

98 D8(+) T cells revealed upregulated cytokine, cytolytic, and metabolic transcriptional activity in the

99 d by the secretion of multiple cytokines and cytolytic antigen-specific T cell responses that were ab

100 L-33 also boosted luminal NETosis and halted cytolytic antiviral activities but did not affect the T(

101 he diminished cross-priming and expansion of cytolytic antiviral CD8(+) T cells.

102 affects membrane integrity as measured using cytolytic assays.

103 as gC1q receptor, protects host cells from a cytolytic attack by antimicrobial peptides (AMPs), such

104 R-CAR-engineered NK cells displayed enhanced cytolytic capability and IFN-gamma production when co-cu

105 ore strongly expressed but has only moderate cytolytic capacities.

106 CD57 expression and, consistently, marginal cytolytic capacity after TCR engagement.

107 , and eomesodermin expression, and increased cytolytic capacity as compared with empty vector control

108 in their expression of NKRs, cytokines, and cytolytic capacity compared with peripheral blood NK cel

109 ore, human STAT5b-deficient NK cells had low cytolytic capacity, and fixed-cell microscopy showed poo

110 +)2B4(+) CD8(+) T cells that correlates with cytolytic capacity, as measured by perforin expression,

111 increased proliferation, IFNgamma secretion, cytolytic capacity, expression of stemness gene signatur

112 -15-induced effector molecule expression and cytolytic capacity.

113 ffector molecule expression as well as their cytolytic capacity.

114 V retain CD8(+) T-cell polyfunctionality and cytolytic capacity.

115 Identification of latency-associated cytolytic CD4 T cells will aid in dissecting mechanisms

116 Our data suggest cytolytic CD4+ T cells as an independent subset distinct

117 Interestingly, we found that cytolytic CD4+ T cells emerge early during acute HIV inf

118 effects have been described, and a role for cytolytic CD4+ T cells in the control of HIV infection h

119 ter flow cytometric analysis of HIV-specific cytolytic CD4+ T cells revealed a distinct transcription

120 Furthermore, HIV-specific cytolytic CD4+ T cells showed comparable killing activit

121 pic, and functional profiles of HIV-specific cytolytic CD4+ T cells.

122 the noncytolytic CD56(bright) NK cell to the cytolytic CD56(dim) NK cells.

123 tients in MMR and MR(4.5) had a more mature, cytolytic CD57(+)CD62L(-) NK cell phenotype, consistent

124 We previously found that cytolytic CD8 T cells promote inflammatory responses tha

125 per cell cytokines or increased migration of cytolytic CD8 T cells within normal tissues.

126 tissue-derived epitopes to directly activate cytolytic CD8 Tcells.

127 that the CD38/NAD/Sirtuin1/EZH2 axis reduces cytolytic CD8(+) T cell function and might be targeted t

128 Cytolytic CD8(+) T cell subsets with effector-like epige

129 o the intravascular circulation, whereas non-cytolytic CD8(+) T cell subsets with stem-like epigeneti

130 of CD160 and 2B4 delineates a population of cytolytic CD8(+) T cells important for the control of HI

131 ng MDSC and redox signaling greatly enhanced cytolytic CD8(+) T-cell response and further decreased r

132 y was dependent on TAA cross presentation to cytolytic CD8+ T cells and on IFN-gamma.

133 able to clearance by immune cells, including cytolytic CD8+ T cells.

134 ut shared similar features with HIV-specific cytolytic CD8+ T cells.

135 yme A expression in CD4 T cells and produces cytolytic cells that can be detected in vivo.

136 ave historically been considered short-lived cytolytic cells that can rapidly respond against pathoge

137 Peripheral LCMV infection can lead to rapid cytolytic clearance or chronic viral persistence; centra

138 Although the role for the cytolytic complement proteins in astrocyte destruction i

139 f HIV-specific CD4+ T cells cooperate in the cytolytic control of HIV replication.

140 ns composed of three-domain Cry proteins and cytolytic Cyt toxins, which are toxic to different mosqu

141 ides evidence of neutrophil NETs interfering cytolytic cytotoxic T lymphocytes (CTLs) and NK cell con

142 Moreover, we identify a GBM-selective cytolytic death mechanism involving plasma membrane targ

143 te-macrophage colony-stimulating factor) and cytolytic degranulation pathway effectors (eg, perforin/

144 Cytolytic degranulation was defined by loss of membrane

145 ough exocytosis, piecemeal degranulation, or cytolytic degranulation.

146 to loss of cellular membrane integrity with cytolytic disruption and release of intact membrane-boun

147 are attached to the carboxy-terminus of the cytolytic domain and contain a beta-trefoil fold and a b

148 xin (LeTx) are refractory to subsequent high cytolytic doses of LeTx, termed toxin-induced resistance

149 Our findings link cytolytic E. faecalis with more severe clinical outcomes

150 that bacteriophages can specifically target cytolytic E. faecalis, which provides a method for preci

151 peutic effects of bacteriophages that target cytolytic E. faecalis.

152 The presence of cytolysin-positive (cytolytic) E. faecalis correlated with the severity of l

153 and CD16, Notch signaling induces increased cytolytic effector capacity and cytokine secretion, even

154 of naive CD8+ T cells into fully functional cytolytic effector cells and mediated the production of

155 ly requires transfer of cells with immediate cytolytic effector function to kill the bulk of fast-gro

156 infected cells from targeted elimination by cytolytic effector functions of the immune system.

157 Importantly, ablation of the cytolytic effector molecule perforin fully protected aga

158 tack complex (MAC) is classically known as a cytolytic effector of innate and adaptive immunity that

159 a highly plastic, hyperinflammatory, poorly cytolytic effector population, which we term "inflammato

160 he capacity to produce a continual supply of cytolytic effector progeny until all malignant cells are

161 onovalent CD3 binding arm designed to engage cytolytic effector T cells (referred to as HIVxCD3 DARTs

162 CTL expansion and delayed the expression of cytolytic effectors during activation.

163 illing kinetics of these cells by CD16.NK-92 cytolytic effectors suggesting that changes in integrin

164 in cancer clinical trials due to the direct cytolytic effects of this treatment that appear to provo

165 cells in in situ proliferation, trafficking, cytolytic effects, and cytokine alarm signaling from mur

166 ade reversed this effect, producing enhanced cytolytic elimination of HCV-infected Huh7.5A2 cells.

167 ctors T-bet and eomesodermin, as well as the cytolytic enzyme perforin, required for the cytotoxic ty

168 ow that fibrinogen is a specific trigger for cytolytic eosinophil degranulation with implications in

169 ing the directional release of cytokines and cytolytic factors toward the antigen-presenting cell.

170 s the directional secretion of cytokines and cytolytic factors.

171 Ig-like receptor(+)CD85j(+)) phenotype, with cytolytic function also against immature dendritic cells

172 tal cues altered airway T(RM) cells to limit cytolytic function and promote cell death, which ultimat

173 g CD8(+) T cell subset that exhibited potent cytolytic function and was required for viral control.

174 ar stomatitis virus infection but comparable cytolytic function at the peak of response.

175 Rab27A missense (p.A87P) mutation on NK cell cytolytic function by cloning it into a lentiviral expre

176 lls, accompanied by IFN-gamma production and cytolytic function in T cells.

177 pretreatment of NK cells in vitro inhibited cytolytic function of both human and mouse NK cells.

178 d by an increase of similar magnitude in the cytolytic function of LN lymphocytes.

179 ave impaired T-cell activation and decreased cytolytic function of natural killer (NK) and CD8 T cell

180 Cytolytic function of the PRF1 p.A91V mutation was teste

181 However, IFN-alpha-enhanced NK cytolytic function was lower in HCV-infected subjects, a

182 load during the early phase of the response; cytolytic function was restored when T cells primed unde

183 Interestingly, granule convergence and cytolytic function were restored after IL-2 stimulation.

184 d by a distinct immunostimulatory phenotype, cytolytic function, and ability to synergize with conven

185 ction by HBHA of a CD4(+) T cell subset with cytolytic function, and as nearly half of these cells al

186 ted by increased NK cell and effector T-cell cytolytic function, reduced T-cell PD-1 expression and r

187 nded solely on mitochondrial respiration for cytolytic function, whereas licensed NK cells demonstrat

188 ession of CD16, perforin, CD57, and impaired cytolytic function.

189 utation, which was shown to decrease NK cell cytolytic function.

190 cells, lactic acid causes the loss of their cytolytic function.

191 ells from LDH-A-depleted tumors had improved cytolytic function.

192 etic changes that specifically regulated the cytolytic functions of airway T(RM) cells and promoted a

193 limumab targeted CTLA-4(+) Treg and restored cytolytic functions of NK cells mediating ADCC.

194 pression of genes controlling tissue homing, cytolytic granule composition, type 1 CD8 cytotoxic T ce

195 iminate pathogen-infected cells by releasing cytolytic granule contents--granzyme (Gzm) proteases and

196 I-expressing orexin(+) neurons, resulting in cytolytic granule polarization toward neurons.

197 ferate extremely rapidly; highly express the cytolytic granule proteins perforin-A, granzyme C (GzmC)

198 e Sec/Munc (SM) protein Munc18-2, facilitate cytolytic granule release by cytotoxic T lymphocytes (CT

199 function depends upon directed secretion of cytolytic granules at the immunological synapse (IS) and

200 including novel distribution of F-actin and cytolytic granules at the IS, programed death protein-1

201 mic mice displayed a marked reduction in the cytolytic granules perforin and granzyme B.

202 the infected epithelial cell exfoliation via cytolytic granules.

203 le organizing center, and the convergence of cytolytic granules.

204 ively activated and induced proliferation of cytolytic human T cells that killed cells from multiple

205 Finally, expression of IL-15 correlated with cytolytic immune functions in patients with B-cell lymph

206 infection induces a virus-specific adaptive/cytolytic immune response that impacts the plasma viral

207 mutational changes influence global NMD and cytolytic immune responses.

208 Binding allows the NLP to become cytolytic in eudicots but not monocots.

209 he AAT-specific T cells in this patient were cytolytic in phenotype, mapped to a peptide in the endog

210 9 secreted different cytokines and were less cytolytic in vitro but surprisingly elicited greater ant

211 Despite being poorly cytolytic in vivo and failing to expand after encounteri

212 y KTX were included, 16,927 (67.5%) received cytolytic induction and 8157 (32.5%) received IL-2RA ind

213 on, and steroid withdrawal; in these groups, cytolytic induction substantially improved clinical outc

214 , and transplant characteristics, the use of cytolytic induction therapy reduced the risk of acute re

215 These data demonstrate that cytolytic induction therapy, as compared with IL-2RA, re

216 ths worldwide, ultimately the consequence of cytolytic infection of CD4(+) T cells.

217 tophagy during the dynamic response of these cytolytic innate lymphocytes.

218 tion and persistent natural killer (NK) cell cytolytic killing.

219 on among hematopoietic cells was observed in cytolytic lymphocytes-including CD8+ cytotoxic T lymphoc

220 ion of activating receptors, polarization of cytolytic machinery and key signaling molecules, and act

221 associated gp350(+) particles may divert the cytolytic machinery, impairing its direct action on the

222 evel, particularly greater expression of the cytolytic marker CD107a from TCD4+ following ECTV infect

223 nal load, neoantigen load, and expression of cytolytic markers in the immune microenvironment were si

224 ively, these results outline RIPK3-activated cytolytic mechanisms essential for controlling respirato

225 ctivation and the consequent mobilization of cytolytic mediators toward the target cell and suggest t

226 Unlike the potently cytolytic melittin, the loss-of-function peptides, inclu

227 ous combinations of cytokines as well as the cytolytic molecule granzyme B.

228 a [TNF-alpha], and interleukin 2 [IL-2]) and cytolytic molecules (granzyme B) and reduced lung viral

229 oliferated and secreted IFN-gamma, IL-13 and cytolytic molecules following atabecestat or DIAT stimul

230 , and LAG3, accompanied by low expression of cytolytic molecules suggests that the decidual microenvi

231 ative response or the secretion of cytokines/cytolytic molecules.

232 s also secreted IFN-gamma, IL-13, IL-22, and cytolytic molecules.

233 is an interleukin-5 receptor alpha-directed cytolytic monoclonal antibody that has been shown to saf

234 decreased transitional B cells and increased cytolytic natural killer (NK) cells.

235 Sorafenib-treated Mvarphi increased cytolytic NK cell function against K562, Raji, and HepG2

236 we also considered viral dynamic models with cytolytic or noncytolytic effector cell responses.

237 cal, alternative, and lectin) and a terminal cytolytic pathway common to all.

238 H is associated with mutations in lymphocyte cytolytic pathway genes, which have not been previously

239 om homozygous mutations in NK and CD8 T cell cytolytic pathway genes.

240 , other amyloidogenic peptides, as well as a cytolytic peptide and a synthetic gel-forming peptide, w

241 identify the first, to our knowledge, fungal cytolytic peptide toxin in the opportunistic pathogen Ca

242 Candidalysin is a cytolytic peptide toxin secreted by Candida albicans hyp

243 We propose the name 'Candidalysin' for this cytolytic peptide toxin; a newly identified, critical mo

244 e to elucidate the effects of polymyxin-B (a cytolytic peptide), valproic acid (a lipophilic drug), a

245 Spider venom neurotoxins and cytolytic peptides are expressed as elongated precursor

246 that can enhance the membrane selectivity of cytolytic peptides by epsilon-lysylation.

247 An involvement in the maturing of cytolytic peptides is very likely, due to high similarit

248 Granule cytolytic perforin/granzyme C from this cell subsequentl

249 of Escherichia coli belong to the family of cytolytic pore-forming Repeats in ToXin (RTX) cytotoxins

250 Intermedilysin (ILY), a cytolytic pore-forming toxin that is secreted by Strepto

251 conformational changes occurring in a large cytolytic pore-forming toxin.

252 emonstrated decreased cytokine secretion and cytolytic potential after specific activation.

253 ng CD8(+) T cells in the tumor with enhanced cytolytic potential and requires T cell migration from l

254 d tissue factor production, as well as their cytolytic potential and their helper function for Ab pro

255 demonstrate that these activated cells gain cytolytic potential by upregulating cytotoxic effector p

256 tive CTLs have substantial proliferative and cytolytic potential.

257 act through Dicer and miRNAs to control the cytolytic program and other aspects of effector CTL diff

258 traepithelial lymphocytes (IELs) with innate cytolytic properties and specificity for the butyrophili

259 transcriptional activity, proliferation, and cytolytic properties.

260 venom is stonustoxin (SNTX), a heterodimeric cytolytic protein that induces cardiovascular collapse i

261 Cytolytic proteins and peptide toxins are classical viru

262 rs showed higher levels of expression of the cytolytic proteins granzymes A and B.

263 forin and granzymes A and B (GzmA and GzmB), cytolytic proteins linked to CD8(+) cell effector functi

264 the inhibitory receptor PD-1, as well as the cytolytic proteins perforin and granzyme B in the infect

265 by promoting polarized secretion of soluble cytolytic proteins toward the intended target.

266 cating that PSMalpha3 has evolved to exhibit cytolytic rather than antimicrobial activity.

267 r adhesion molecule-1 (ICAM-1) inhibited the cytolytic response of CD4-MBL CAR-T cells to Env-express

268 ability to initiate an immediate and direct cytolytic response to virally infected or malignantly tr

269 mune responses, including excessively robust cytolytic responses to M. tuberculosis in vitro, at the

270 Cytolytic score (CYT), calculated from mRNA expression l

271 ics relevant to immunotherapy response (i.e. Cytolytic score, PDL1 expression).

272 These findings provide new insights into the cytolytic signaling pathway of NKG2D and the pathogenesi

273 and cytolysis correlate for weakly adherent/cytolytic strains, and a threshold of attachment was fou

274 Importantly, high intra-tumoral cytolytic T cell inflammation prior to MAPKi therapy pre

275 n of antigenic peptides recognized by CD8(+) cytolytic T cells (CTL).

276 GITR agonism was not sufficient to activate cytolytic T cells due to persistent exhaustion.

277 Cytolytic T cells eliminate infected or cancer cells by

278 , a major population of innate-like resident cytolytic T cells, have remained elusive.

279 an be used to perform drug screens, to study cytolytic T lymphocyte (CTL) responses to HIV-1, to comp

280 l (Treg) numbers with enhanced expression of cytolytic T lymphocyte-associated antigen 4, potentiatin

281 Natural killer (NK) cells and cytolytic T lymphocytes (CTLs) eliminate pathogen-infect

282 and subsequent killing of infected cells by cytolytic T lymphocytes (CTLs) or viral cytopathic effec

283 targeted broadly neutralizing antibodies and cytolytic T lymphocytes, and animal models for the study

284 gh CEACAM6 expression is associated with low cytolytic T-cell activity in both basal and classical PD

285 ic T-lymphocyte responses that can result in cytolytic targeting of the tumor.

286 o IFN-gamma- and granzyme-B (GrzB)-producing cytolytic Tc1-like effector cells.

287 l genetic loci that affect the expression of cytolytic toxicity and biofilm formation.

288 Whereas elevated cytolytic toxicity in combination with low levels of bio

289 ytolysin (VCC) is a potent membrane-damaging cytolytic toxin that belongs to the family of beta barre

290 P3 activation requires GBS expression of the cytolytic toxin, beta-hemolysin, lysosomal acidification

291 equire live bacteria (i.e., the formation of cytolytic toxins), which are essential for IFN-beta indu

292 tify novel loci that alter the expression of cytolytic toxins, a polymorphism in the cyoE gene, which

293 s were repressed in their ability to secrete cytolytic toxins, and this appears to be mediated throug

294 daptomycin, Agr-triggered secretion of small cytolytic toxins, known as phenol soluble modulins, prev

295 loss of the ability of S. aureus to secrete cytolytic toxins, protect itself from several aspects of

296 d RNAIII transcription prevents synthesis of cytolytic toxins.

297 l within a host, including the production of cytolytic toxins.

298 Determine the impact of cytolytic versus IL-2 receptor antibody (IL-2RA) inducti

299 e ability of NK cells to degranulate CD107a+ cytolytic vesicles was reduced (11% vs 22%; P = 0.02), a

300 velope, it has been thought to be inherently cytolytic, wherein CVB can escape from the infected host