ライフサイエンスコーパス: cytoplasmic domain

1 r potassium (Kir) channels is the unique Kir cytoplasmic domain.

2 on to both the stalk region and parts of the cytoplasmic domain.

3 Y6 of a potential hemi-ITAM motif in BST2's cytoplasmic domain.

4 ossibly due to aggregation propensity of its cytoplasmic domain.

5 ols fates of mRNAs localized within the same cytoplasmic domain.

6 equires its transmembrane domain but not its cytoplasmic domain.

7 o induce important allosteric changes in the cytoplasmic domain.

8 exinA4 requires the Sema domain, but not the cytoplasmic domain.

9 ssociate with actin filaments and the ICAM-1 cytoplasmic domain.

10 rane-distal NPxY motif in the beta1 integrin cytoplasmic domain.

11 eir dendrites, an effect that requires Drl's cytoplasmic domain.

12 se cleavage, or nuclear translocation of its cytoplasmic domain.

13 ct prosurvival signals mediated by the 4-1BB cytoplasmic domain.

14 architecture and function of a P2X receptor cytoplasmic domain.

15 on, and coordinated by regions of the beta4C cytoplasmic domain.

16 residues clustered within an amino-terminal cytoplasmic domain.

17 s(*)5]) are predicted to lead to a truncated cytoplasmic domain.

18 altering the affinity of TRIP8b for the HCN cytoplasmic domain.

19 d by two transmembrane segments and a single cytoplasmic domain.

20 e domain, serine rich region and a conserved cytoplasmic domain.

21 to characterize the regulatory roles of CLC cytoplasmic domains.

22 protein-protein interactions involving their cytoplasmic domains.

23 ed sites were found in the N- and C-terminal cytoplasmic domains.

24 d tandem kinase and endoribonuclease (RNase) cytoplasmic domains.

25 iplasmic domains and transcription activator cytoplasmic domains.

26 of specific cysteine residues located in the cytoplasmic domains.

27 /Toll-7 in wiring specificity, nor are their cytoplasmic domains.

28 multiple autophosphorylation sites in their cytoplasmic domains.

29 eins with small ER luminal domains and large cytoplasmic domains.

30 tructurally, BST-2 consists of an N-terminal cytoplasmic domain, a transmembrane domain, an ectodomai

31 pha-catenin*beta-catenin*epithelial cadherin cytoplasmic domain (ABE) using negative stain electron m

32 In the structure, the cytoplasmic domain adopts a closed conformation and the

33 sult in talin-1 binding to the integrin beta cytoplasmic domain and consequent integrin activation, p

34 es, an effect that depended on the TbetaRIII cytoplasmic domain and did not require TbetaRIII ectodom

35 ctivation involves upward translation of the cytoplasmic domain and formation of state-dependent inte

36 sional organization is mostly encoded by its cytoplasmic domain and is regulated by tuning the affini

37 CaMK2D also phosphorylates CEACAM1 on its cytoplasmic domain and mutation of these phosphorylation

38 on reminiscent to the PRC but located in the cytoplasmic domain and possibly stabilized by D38.

39 g through an ER retention motif, whereas the cytoplasmic domain and prodomain processing are not requ

40 to both forming and mature CNS nodes via its cytoplasmic domain and requires intact paranodes.

41 is report, we investigated the role of CD103 cytoplasmic domain and the focal adhesion-associated pro

42 red a novel interaction between the calnexin cytoplasmic domain and UBC9, a SUMOylation E2 ligase, wh

43 pressing FcgammaRIIa and FcgammaRIIb lacking cytoplasmic domains and in which the transmembrane domai

44 of these networks, directly binding integrin cytoplasmic domains and mediating interactions with cyto

45 teracts with VEGFRs through their respective cytoplasmic domains and promotes VEGFR activation in flo

46 of a protein complex containing Vpu and BST2 cytoplasmic domains and the core of the clathrin adaptor

47 g in a kinase-on conformation stabilizes the cytoplasmic domain, and signaling inputs that destabiliz

48 , we show that PD-L1 is palmitoylated in its cytoplasmic domain, and that this lipid modification sta

49 of arid3a from the plasma membrane while the cytoplasmic domain appears critical for the cleavage of

50 rk between the ligand-binding pocket and the cytoplasmic domains appears to play a similar role in si

51 ple for how the widespread four-helix bundle cytoplasmic domain architecture can control VGIC respons

52 the last C-terminal 10 amino acids in Cad11 cytoplasmic domain are required for Amot binding.

53 the KRK motif within the Plexin-A4 receptor cytoplasmic domain, are required to coordinate the downs

54 on with our previous studies implicating the cytoplasmic domain as an intracellular iron sensor, thes

55 ocking and identified three cysteines in the cytoplasmic domain as being critical for covalently stab

56 as well as throughout the transmembrane and cytoplasmic domains as a result of the elimination of th

57 ial roles for the receptor transmembrane and cytoplasmic domains, as well as for the TARP extracellul

58 ulation of the small phosphoprotein integrin cytoplasmic domain-associated protein-1 (ICAP1) results

59 Binding of ICAP1 (integrin cytoplasmic domain-associated protein-1) to the cytoplas

60 s of RNP granules populate the germ plasm, a cytoplasmic domain at the posterior of the Drosophila oo

61 he R165A mutation results in splaying of the cytoplasmic domains away from the central axis and that

62 eptor tyrosine-based activation motif in its cytoplasmic domain, binding of FcgammaRI can result in a

63 infusion of an antibody targeting the GluN1 cytoplasmic domain blocks agonist-driven FRET changes in

64 anchored to the alpha6beta4 integrin via its cytoplasmic domain, but the activation of cell motility

65 ation E2 ligase, which modified the calnexin cytoplasmic domain by the addition of SUMO.

66 uncover a mechanism by which rotation of the cytoplasmic domain can modulate GIRK*PIP interactions.

67 g transiently reduces FRET between the NMDAR cytoplasmic domain (cd) and the associated protein phosp

68 ly, V459K and K461G mutations within the GP2 cytoplasmic domain (CD) of rCl-13/LASV-GPC were shown to

69 independent coupling of agonist to the NMDAR cytoplasmic domain (cd).

70 Isoforms of PCDH15 differ in their cytoplasmic domains (CD1, CD2, and CD3), but share the e

71 E-Syt cytoplasmic domains comprise a synaptotagmin-like mitoch

72 ompared accumulation of NF186 ectodomain and cytoplasmic domain constructs in WT versus paranode defe

73 WC1 cytoplasmic domains contains multiple tyrosines, one of

74 c domain implicated in signal sensing, and a cytoplasmic domain controlling activation of the regulat

75 Moreover, we show that the SorCS3 cytoplasmic domain conveys internalization through canon

76 a-secretase 1 (BACE1), whose ectoplasmic and cytoplasmic domains could both be specifically targeted

77 ly distinct P2X subtype, containing a unique cytoplasmic domain critical for the receptor to initiate

78 e-gated sodium channel (BacNa(V)) C-terminal cytoplasmic domain (CTD) affects function.

79 SD), a central pore-gate domain, and a large cytoplasmic domain (CTD) that contains the Ca(2+) sensor

80 n activatory mutation (S205L) located in the cytoplasmic domain (CTD).

81 sion appears restricted by its intraviral or cytoplasmic domain (cytodomain) because mutations within

82 r ezrin/radixin/moesin (ERM) proteins on its cytoplasmic domain (DeltaANKDeltaERM) did not cluster.

83 t coagulation factor VIIa (FVIIa) elicits TF cytoplasmic domain-dependent proangiogenic cell signalin

84 PlxnA signaling requires cytoplasmic domain dimerization, but extracellular regul

85 ization of Cebpb transcripts to a peripheral cytoplasmic domain distinct from the PSC region.

86 t excludes a functional role for the basigin cytoplasmic domain during invasion.

87 iently disordered is a structural feature of cytoplasmic domain dynamics that varies with functional

88 increased only modestly, suggesting that the cytoplasmic domain engages the cytoskeleton by an additi

89 M, leading to nuclear internalization of its cytoplasmic domain EpICD.

90 , we report that these N-terminal ARs form a cytoplasmic domain essential for NOMPC mechanogating in

91 ng a high-mobility ICAM-1 mutant lacking the cytoplasmic domain exhibit diminished antigen-dependent

92 after reaching the plasma membrane, and the cytoplasmic domain facilitated these processes.

93 Thus, the cytoplasmic domain facilitates proton conduction through

94 ical among integrins in lacking sites in its cytoplasmic domain for binding to actin cytoskeleton ada

95 t genotypic determinants in gag and the gp41 cytoplasmic domain (gp41-CD) reduce protease inhibitor (

96 ding Ser-675 (APP(695) numbering) in the APP cytoplasmic domain has been found to be phosphorylated.

97 er, lack of structural information about the cytoplasmic domain has hindered understanding of the mol

98 The receptor cytoplasmic domain has previously been shown to be highl

99 tic processing of cadherin extracellular and cytoplasmic domains has been reported to regulate cadher

100 cently, interactions mediated via the CTLA-4 cytoplasmic domain have been shown to preferentially aff

101 Whereas its membrane-proximal and cytoplasmic domains have been functionally and structura

102 Amino acid substitutions in PhoQ's cytoplasmic domain hindered activation by acidic pH and

103 a mutant isoform of IgSF9 lacking the entire cytoplasmic domain (IgSF9(DeltaC/DeltaC) mice) had no de

104 residue (Leu-919) upstream of the C-terminal cytoplasmic domain in AHA2.

105 cribe an unexpected function for the MT1-MMP cytoplasmic domain in imprinting spatial memory for podo

106 way analyses support a separate role for the cytoplasmic domain in initiation of intracellular signal

107 Using the human Cad11 cytoplasmic domain in pulldown assays, we identified hum

108 redicted to modulate the PMM activity of the cytoplasmic domain in response to as yet unidentified en

109 Immunization with AChR cytoplasmic domains in adjuvant is promising as a safe,

110 the dimer interface, whereas the N-terminal cytoplasmic domain includes a rhodanese-fold in accordan

111 It interacts with Munc18-1 through its cytoplasmic domains, including the N-terminal peptide (N

112 onine motif (T788/T789) in the integrin beta cytoplasmic domain increases integrin activity.

113 n of VWF (VWF-A1) on GPIb-IX captured by its cytoplasmic domain induced unfolding of a hitherto unide

114 igomerization is indirect and depends on its cytoplasmic domain interactions with scaffold proteins (

115 e found that incorporation of the CD3epsilon cytoplasmic domain into a second-generation chimeric ant

116 retase cleavage and the translocation of the cytoplasmic domain into the nucleus.

117 l adaptor protein talin to the beta-integrin cytoplasmic domain is a key final step in regulating the

118 In addition, the adam13 cytoplasmic domain is cleaved by gamma secretase, transl

119 In contrast, Pcdh15a lacking the entire cytoplasmic domain is not functional.

120 We propose that the function of CTLA-4 cytoplasmic domain is not to transmit inhibitory signals

121 n on specific Ser and/or Thr residues in the cytoplasmic domain is often critical for the activation

122 lls and that the remaining membrane spanning cytoplasmic domain is processed by gamma-secretase compl

123 e show here that the KRK motif in the PlxnA4 cytoplasmic domain is required for Sema3A-mediated corti

124 Allosteric regulation of the pore by the cytoplasmic domains is mediated through extensive intera

125 binding of cytoskeletal adaptors to integrin cytoplasmic domains is sufficient for activation or whet

126 Phosphorylation of Thr-457 on the short cytoplasmic domain isoform (CEACAM1-SF) that is predomin

127 astric cancer and to address whether CEACAM1 cytoplasmic domain isoform balance modulates the propert

128 1 and Tmc2a can interact with the CD1 or CD3 cytoplasmic domain isoforms of Pcdh15a, and this interac

129 ack of the putative endocytosis motif in its cytoplasmic domain largely abolished the sensitivity of

130 1229) at the ankyrin binding motif of the L1 cytoplasmic domain, leading to the dissociation of L1 fr

131 M-MLV glycoGag construct, truncations of the cytoplasmic domain led to a near total loss of activity.

132 ce of typical SLAM signaling motifs in their cytoplasmic domains, likely reflecting the evolutionary

133 FtsN function, a variant of FtsN lacking the cytoplasmic domain localized to the divisome but failed

134 bserved during binding are propagated to the cytoplasmic domain, multiple mutations were introduced i

135 t conformation by integrin transmembrane and cytoplasmic domains must be overcome by cellular energy

136 he VEGF164-binding site of NRP1 and the NRP1 cytoplasmic domain (NCD), but not the known NCD interact

137 beta4 expressed in normal tissue, contains a cytoplasmic domain of 231 amino acids with a unique sequ

138 or complex and ITIM tyrosine residues in the cytoplasmic domain of 3DL1.

139 CAM is a type I transmembrane protein with a cytoplasmic domain of 59 (Lu) or 19 (Lu(v13)) amino acid

140 Here we show that a recombinant cytoplasmic domain of ADAM10 (A10Cp) is unstructured as

141 In comparison, recombinant transmembrane-cytoplasmic domain of ADAM10 (A10TmCp) reconstituted in

142 Thus, the cytoplasmic domain of ADAM10 negatively influences const

143 We report that the cytoplasmic domain of ADAM10 negatively regulates its co

144 c transmembrane domain of L-selectin and the cytoplasmic domain of ADAM10 produces a similar dimeriza

145 embrane domain of ADAM17 with or without the cytoplasmic domain of ADAM17 show reduced stimulated she

146 s, we found a direct interaction between the cytoplasmic domain of ATP1A1 and FGF2 with submicromolar

147 t features of structure and signaling in the cytoplasmic domain of bacterial chemoreceptors.

148 R; (ii) it binds the tyrosine phosphorylated cytoplasmic domain of band 3 (cdb3-PO4) with Kd = 14 nM;

149 INCH-parvin (IPP) complex interacts with the cytoplasmic domain of beta-integrin subunits and is crit

150 ain to the membrane-distal NPxY motif in the cytoplasmic domain of beta1 integrin in early endosomes.

151 The cytoplasmic domain of BRI1 contains five putative canoni

152 ctrometry, we confirmed that the recombinant cytoplasmic domain of BRI1 generates pmol amounts of cGM

153 e of a fusion protein comprising Nef and the cytoplasmic domain of CD4 bound to the tetrameric AP2 co

154 ate a synthetic peptide corresponding to the cytoplasmic domain of CEACAM1-SF and was covalently boun

155 rt that mutations K465V and G467K within the cytoplasmic domain of Cl-13 GP2 resulted in a virus, rCl

156 The dNP2-conjugated cytoplasmic domain of cytotoxic T-lymphocyte antigen 4 (

157 tyrosine- and asparagine-based motif in the cytoplasmic domain of DNAM-1.

158 at conserved positions within the C-terminal cytoplasmic domain of each protein is required for optim

159 A cytoplasmic domain of either the channel or an accessory

160 ontribution of signaling orchestrated by the cytoplasmic domain of EphB2 (a newly discovered Eph kina

161 Here we describe the structure of the 60-kDa cytoplasmic domain of EzrA, which comprises five linear

162 We conclude that the cytoplasmic domain of FcgammaR is not required for promo

163 the extracellular domain of KLA fused to the cytoplasmic domain of FGFR and employ total internal ref

164 These lie in a small, well-conserved cytoplasmic domain of FlhA, located between transmembran

165 new requirement for interaction between the cytoplasmic domain of FtsN ((N) FtsN) and FtsA.

166 N bypassed ZipA and a conserved motif in the cytoplasmic domain of FtsN was required for both the byp

167 biochemical measurement-that SarA mimics the cytoplasmic domain of glycoprotein 130 (gp130, IL6ST).

168 hed from Nef to Vpu due to a deletion in the cytoplasmic domain of human tetherin, HIV-1 group O, whi

169 ength ICAM-1 or a truncated form lacking the cytoplasmic domain of ICAM-1.

170 blasts through the signaling function of the cytoplasmic domain of ICAM-1.

171 pproaches to examine the likelihood that the cytoplasmic domain of ICAM-2 binds directly to alpha-act

172 Mechanistically, the cytoplasmic domain of IL-13Ralpha2 specifically binds to

173 Here, we present the atomic structure of the cytoplasmic domain of IncA, which reveals a non-canonica

174 ns, the mobility of helical backbones in the cytoplasmic domain of intact chemoreceptor Tar homodimer

175 y recruiting and activating caspase 8 to the cytoplasmic domain of integrin alphavbeta3.

176 ly we found that Galpha13 interacts with the cytoplasmic domain of integrin beta3 subunits in platele

177 rt that fortilin directly interacts with the cytoplasmic domain of IRE1alpha, inhibits both kinase an

178 of key regulatory residues within the large cytoplasmic domain of KCC2 in neurons.

179 , coupled with the contrasting intracellular cytoplasmic domain of LAG3 as compared with other IRs, h

180 Furthermore, the cytoplasmic domain of M-MLV glycoGag was fully sufficien

181 for phosphorylation of tyrosine Y573 in the cytoplasmic domain of MT1-MMP by LIMK.

182 l or transcriptional mechanisms and that the cytoplasmic domain of MT2 is necessary for its regulatio

183 d a protein transduction approach, where the cytoplasmic domain of Neph1 (Neph1CD) tagged with a prot

184 ns except for a single point mutation in the cytoplasmic domain of NLGN4X in which an arginine is mut

185 We show that phosphorylation of the cytoplasmic domain of p14 triggers N-WASP-mediated assem

186 in microarray AtPMA-5000 with the N-terminal cytoplasmic domain of PEN3.

187 the GTP-bound state, RhoJ interacts with the cytoplasmic domain of PlexinD1.

188 he structure of its interacting partner, the cytoplasmic domain of PscD (SctD).

189 The cytoplasmic domain of PscD forms a forkhead-associated (

190 led FKBP (FK506-binding protein 12.6) on the cytoplasmic domain of RyR in isolated sarcoplasmic retic

191 Binding of the cytoplasmic domain of sAnk1 to SERCA1 was also detected

192 Interaction between SigG and the predicted cytoplasmic domain of SapG was observed in vitro.

193 dence that GIE stiffness is dependent on the cytoplasmic domain of STEVOR that interacts with ankyrin

194 e identify gain-of-function mutations in the cytoplasmic domain of STIM1 (p.R304W) associated with th

195 urther identify critical residues within the cytoplasmic domain of STIM1 (STIM1-CT) that entail autoi

196 The cytoplasmic domain of STING forms a dimer, which undergo

197 when V1 is released from Vo, the N-terminal cytoplasmic domain of subunit a (aNT) changes conformati

198 is study, we report a connection between the cytoplasmic domain of TANGO1 and SLY1, a protein that is

199 uced in high-fat diet-fed mice that lack the cytoplasmic domain of TF (F3) (TF(DeltaCT)) or that are

200 study, a yeast two-hybrid approach using the cytoplasmic domain of TfR2 identified CD81 as an interac

201 g, we examine the structural dynamics of the cytoplasmic domain of the beta2-adrenergic receptor (bet

202 of the Galpha13 protein from binding to the cytoplasmic domain of the beta3 integrin prevents outsid

203 atrix receptor syndecan (Sdc)-1 engaging the cytoplasmic domain of the beta4 integrin and coupling of

204 syndecan-1 (Sdc1), in which Sdc1 engages the cytoplasmic domain of the beta4 integrin subunit allowin

205 to how cAMP-dependent phosphorylation of the cytoplasmic domain of the essential invasion adhesin api

206 direct interaction between Galpha13 and the cytoplasmic domain of the integrin beta1 subunit plays a

207 th the IR via specific interactions with the cytoplasmic domain of the IR protein MxiG (MxiG(C)), whi

208 ect binding to SR-B1 and an eight-amino-acid cytoplasmic domain of the receptor that recruits the gua

209 illogenesis, stable interactions between the cytoplasmic domain of the type II TGF-beta receptor (Tbe

210 examines the role of a lysine cluster in the cytoplasmic domain of the VZV fusion protein, gB, in the

211 rin through a membrane-proximal motif in the cytoplasmic domain of VE-cadherin.

212 Using NMR spectroscopy, we find that the cytoplasmic domain of Vpu and Trp-76 specifically intera

213 The cytoplasmic domain of VZV gB (gBcyt) has been implicated

214 extracellular CD4 and the transmembrane and cytoplasmic domain of WC1.

215 ain of syndecan-4, and the transmembrane and cytoplasmic domains of cadherin-11.

216 interaction of SET with the newly translated cytoplasmic domains of CD47 and results in subsequent tr

217 14-tau was also abundant within synaptic and cytoplasmic domains of dendritic spines.

218 ies, here we combined the DrBpP-PCM with the cytoplasmic domains of EGFR and FGFR1.

219 that reconstitution of the transmembrane and cytoplasmic domains of EGFR in vesicles leads to a pecul

220 study, we engineered covalent dimers of the cytoplasmic domains of Escherichia coli CpxA, enabling u

221 el based on proton-actuated movements in the cytoplasmic domains of FlhA.

222 postherpetic neuralgia, is regulated by the cytoplasmic domains of gB (gBcyt) via an immunoreceptor

223 We measure FRET between fluorescently tagged cytoplasmic domains of GluN1 subunits of NMDARs expresse

224 vaccine consisting of bacterially expressed cytoplasmic domains of human AChR subunits reduced the d

225 cs simulations on complete transmembrane and cytoplasmic domains of integrin alphaIIbbeta3, talin1 F2

226 rotein regions are widely distributed in the cytoplasmic domains of many transmembrane receptors.

227 To evaluate the role of cytoplasmic domains of membrane-spanning proteins in dir

228 a, and directly binds and phosphorylates the cytoplasmic domains of NFR5 and NFR1 in vitro.

229 The interaction of the pentamer places the cytoplasmic domains of PLN at the membrane surface proxi

230 The cytoplasmic domains of prokaryotic and eukaryotic Kir ch

231 These data reveal an interaction between the cytoplasmic domains of Ptch1 and that these domains modu

232 rified proteins to assess interaction of the cytoplasmic domains of SPCA1 with actin and CFL-1.

233 This regulation was mediated by the cytoplasmic domains of the AQPs.

234 ptor tyrosine-based activation motifs in the cytoplasmic domains of the CD79a and CD79b signaling sub

235 h at least three distinct regions within the cytoplasmic domains of the channel that contain conserve

236 ) ectodomains fused to the transmembrane and cytoplasmic domains of the NDV F and HN proteins, respec

237 is defined by conformational changes in the cytoplasmic domains of the protein that are allosterical

238 s on polybasic sequences in HIV-1 Gag and in cytoplasmic domains of the transmembrane proteins.

239 Sorting motifs contained within the cytoplasmic domains of transmembrane proteins, post-tran

240 ne system uses chaperones to detect unfolded cytoplasmic domains of transmembrane proteins, whereas t

241 Overexpression of the cytoplasmic domain or full-length EDTB induces transloca

242 for anterograde axonal transport, and gE/gI cytoplasmic domains play important roles in sorting of v

243 apes the G(betagamma) binding surface on the cytoplasmic domain, preparing it to receive G(betagamma)

244 ignal in the SIVmac239 envelope glycoprotein cytoplasmic domain, producing a virus termed DeltaGY, le

245 smembrane domains, but it is unknown how the cytoplasmic domain propagates the signal an additional 2

246 tch-clamp fluorometry, we confirmed that the cytoplasmic domains rearrange during VRAC opening.

247 Alternative splicing of the PCDH15 cytoplasmic domain regulates formation of this ternary c

248 ) exchange patterns, suggesting the receptor cytoplasmic domain retains disorder even within function

249 ice expressing a truncated Robo4 lacking the cytoplasmic domain (Robo4DeltaCD).

250 M2 distal cytoplasmic domain sequences were still required for opt

251 , which lacks the transmembrane spanning and cytoplasmic domains, serves as a homology model of the e

252 esion kinase (FAK) via a constant C-terminal cytoplasmic domain shared by all 22 proteins.

253 trast to the TM peptide, indicating that the cytoplasmic domain shifts the protonation equilibria.

254 esence of a polybasic sequence in the PSGL-1 cytoplasmic domain significantly enhanced this cocluster

255 of the endocytic dileucine motif in the WC1 cytoplasmic domain significantly reduced PMA-induced end

256 ation in GIRK2 that causes a rotation in the cytoplasmic domain, similarly to G(betagamma)-binding to

257 fying potassium (Kir) channel family share a cytoplasmic domain structure that serves as an unusual A

258 y we showed that salt bridges located at the cytoplasmic domain subunit interfaces (CD-Is) of eukaryo

259 inding initiates a concerted rotation of the cytoplasmic domain subunits, which is stabilized by mult

260 er resistance to trypsin digestion, with its cytoplasmic domain taking on a significant ordered struc

261 llular level, we demonstrate that the SorCS3 cytoplasmic domain targets receptors to the Golgi appara

262 ted zebrafish bearing a deletion in the Flt4 cytoplasmic domain that eliminates tyrosines Y1226 and 1

263 tional change that affects the other, larger cytoplasmic domain that interacts with the export cargo.

264 tivation required an arginine residue in the cytoplasmic domain that is critical for blocking NF-kapp

265 erized, 12-amino acid region within the NRP1 cytoplasmic domain that mediates HH signal promotion.

266 oltage-gated K(+) channel motif coupled to a cytoplasmic domain that mediates subfamily-exclusive ass

267 Many immunoreceptors have cytoplasmic domains that are intrinsically disordered (i

268 channels (VGICs) are outfitted with diverse cytoplasmic domains that impact function.

269 tion of Asp351 causes areorganization of the cytoplasmic domains that subsequently drives the opening

270 osing of luminal gate induces a shift in the cytoplasmic domains that subsequently enables the dephos

271 view of the interaction and dynamics of the cytoplasmic domain, the membrane domain, and the connect

272 dependent unfolding transition in a discrete cytoplasmic domain, the neck domain, proximal to the por

273 In addition to distinct cytoplasmic domains, the luminal KASH domain also varies

274 nding are dependent on proper folding of the cytoplasmic domains, the signal provides a common qualit

275 talin-1 and kindlin-3 to the beta2 integrin cytoplasmic domain, thereby being indispensable for beta

276 Binding of FtsN's cytoplasmic domain to a protein named FtsA recruits a sm

277 cit significant remodeling of the C-terminal cytoplasmic domain to expose docking sites for signaling

278 ly, ARF elevates nMET through binding to MET cytoplasmic domain to stabilize MET.

279 e-inactivating point mutation or lacking the cytoplasmic domain to uncouple the enzymatic and noncata

280 cAMP binding rotates cytoplasmic domains to favor opening of the inner helica

281 We used His-tagged constructs of complete cytoplasmic domains to identify a total of 592 phosphory

282 nk1 interacts with SERCA1 through its TM and cytoplasmic domains to regulate SERCA1 activity and modu

283 In the docked form the cytoplasmic domain, to which G(betagamma) binds, becomes

284 rrantly persists into adulthood, whereas the cytoplasmic domain/transport-dependent targeting is impa

285 Collectively, we identify a cytoplasmic domain, unique to BASIC, that controls chann

286 C3 isoform, we show that its unique variable cytoplasmic domain (VCD) is the critical one for Wnt pat

287 -signaling autoinhibitory separation for the cytoplasmic domains via intermolecular head-to-stalk int

288 Unexpectedly, however, GPP130's cytoplasmic domain was not required, and redistribution

289 ation of the ankyrin binding motif in the L1 cytoplasmic domain was studied after NAP treatment of in

290 t Lu dimerization and phosphorylation of its cytoplasmic domain were concomitantly needed to promote

291 Interestingly, the periplasmic and cytoplasmic domains were somewhat dispensable for flagel

292 een investigated in the presence of the full cytoplasmic domain, which increases the proton conductiv

293 er pKa to direct and indirect effects of the cytoplasmic domain, which is rich in acidic residues.

294 tegrins transduce signals from ECM via their cytoplasmic domains, which bind to intracellular integri

295 triggers tyrosine autophosphorylation of the cytoplasmic domains, which stimulates catalytic activity

296 and vessel permeability independently of its cytoplasmic domain, while activating VEGFR2-Y951 via ROB

297 the norm, with an average of seven sites per cytoplasmic domain, while some proteins showed more than

298 chored to actin through interaction of their cytoplasmic domains with related tripartite complexes co

299 Cs enhances interactions of their respective cytoplasmic domains with the plasma membrane and stabili

300 the BACE1 transmembrane sequences (TMSs) and cytoplasmic domains, with residues Ala(463) and Cys(466)