ライフサイエンスコーパス: cytoprotective

1 atocyte-derived Gal-9 is both diagnostic and cytoprotective.

2 ng, while in normal cells CD40 signalling is cytoprotective.

3 n greatly enhances eEF2K activity and may be cytoprotective.

4 , p38alpha is proinflammatory and p38beta is cytoprotective.

5 ized persulfide donors on HeLa cells and the cytoprotective ability in the highly oxidizing cellular

6 2S produced by the endogenous enzymes exerts cytoprotective actions.

7 Specific bifidobacteria might have cytoprotective activities, but little is known about the

8 s controlling intracellular localization and cytoprotective activity are incompletely understood.

9 nhibition of APC's anticoagulant but not its cytoprotective activity can be beneficial for hemophilia

10 indings highlight the strong antioxidant and cytoprotective activity of the extract components, and i

11 The same was found for cytoprotective activity on lymphocytes, lipid peroxidati

12 e PPF were potent antioxidants and displayed cytoprotective activity through the activation of nuclea

13 A significant cytoprotective activity was observed when AGS cells were

14 phenolic composition, antioxidant power and cytoprotective activity.

15 the highest GluN2B affinity and the highest cytoprotective activity.

16 nsights into TMBIM-mediated calcium leak and cytoprotective activity.

17 also analyzed the role of DJ-1, which has a cytoprotective activity.

18 endent phospholipase A2gamma (iPLA2gamma) is cytoprotective against complement-mediated GEC injury.

19 endent phospholipase A2gamma (iPLA2gamma) is cytoprotective against complement-mediated glomerular ep

20 roduced by bacteria and has been shown to be cytoprotective against oxidative stress and to increase

21 AAP-induced toxicity and may be considered a cytoprotective agent in this in vitro model of drug indu

22 ry compound worth further investigation as a cytoprotective agent.

23 are currently undergoing clinical trials as cytoprotective agents for the management of neurodegener

24 vage at Arg46-PAR1, which is known to confer cytoprotective and anti-inflammatory activities.

25 humans, together with their well-documented cytoprotective and anti-inflammatory effects in preclini

26 human activated protein C (rhAPC) has shown cytoprotective and anti-inflammatory functions in some c

27 to the discovery of its role in vasoactive, cytoprotective and anti-inflammatory responses.

28 CXCR3-B down-regulated the expression of the cytoprotective and antiapoptotic molecule heme oxygenase

29 end-organ protective properties mediated via cytoprotective and antiinflammatory mechanisms.

30 tion by activated protein C (APC) stimulates cytoprotective and antiinflammatory signaling.

31 isms that allow rapid switch on/off of their cytoprotective and apoptosis-inducing signaling pathways

32 Here we discuss how cytoprotective and cytotoxic signaling modules activated

33 ein C (APC) and thrombin elicits paradoxical cytoprotective and cytotoxic signaling responses in vasc

34 bilirubin and a signaling molecule that has cytoprotective and immunomodulatory effects.

35 gulates the expression of a large network of cytoprotective and metabolic enzymes and proteins.

36 using thiazolidinediones has potent podocyte cytoprotective and nephroprotective effects.

37 cytoplasmic ribonucleoprotein complexes with cytoprotective and pro-survival properties.

38 present evidence that PINK1-Parkin has both cytoprotective and proapoptotic functions.

39 identify the role of NF-kappaB in mediating cytoprotective and proinflammatory responses to inflamma

40 ral well-established and recently discovered cytoprotective and RNA-based Hsp70 functions.

41 nctional serine protease with anticoagulant, cytoprotective, and anti-inflammatory activities.

42 o examine expression levels of inflammatory, cytoprotective, and injury genes at different time point

43 endothelial growth factor (VEGF)-B activates cytoprotective/antiapoptotic and minimally angiogenic me

44 The cytoprotective antioxidant N-acetylcysteine inhibited Dp

45 c apoptotic pathway which could overcome the cytoprotective autophagic mechanism.

46 ent, ATF4 activated a coordinated program of cytoprotective autophagy and antioxidant responses, incl

47 ement for functional p53 in the promotion of cytoprotective autophagy by radiation was confirmed by t

48 Because SFN treatment induces cytoprotective autophagy in cultured human prostate canc

49 tosis, wherein targeting SQSTM1/p62 converts cytoprotective autophagy to an inefficient form due to c

50 lines, BRAFi or BRAF/MEK inhibition induced cytoprotective autophagy, and autophagy inhibition enhan

51 stress response that subsequently activated cytoprotective autophagy.

52 amined the calcium-induced expression of the cytoprotective beta cell transcription factor Npas4.

53 On the basis of the cytoprotective capabilities of antifreeze proteins (AFPs

54 FBSH-III retained antioxidant activity and cytoprotective capacity after in vitro simulated gastroi

55 mitochondria-associated peptide that offers cytoprotective, cardioprotective, and neuroprotective ef

56 ble, whereas anti-inflammatory signaling and cytoprotective cell signaling by APC are essential.

57 ify robenidine as a PP1:PPP1R15A-independent cytoprotective compound that holds potential for the man

58 ozyme, was identified as a novel and leading cytoprotective compound.

59 Prestwick drug library to identify putative cytoprotective compounds against light-induced, syntheti

60 , C. album (poly)phenols appear as promising cytoprotective compounds, modulating central events in t

61 trials is that therapy-induced autophagy is cytoprotective; consequently, inhibition of autophagy is

62 s), furan compounds (HMF and furfural F) and cytoprotective/cytotoxic effects upon Caco-2 cells (MTT,

63 this metabolic shift is the upregulation of cytoprotective (CyTP) genes categorized in the Gene Onto

64 of mechanisms modulated by ROS that trigger cytoprotective detoxification via macroautophagy.

65 Since eEF2K is cytoprotective during hypoxia and other conditions of nu

66 2)(*-) and HO(*) scavenging activity and the cytoprotective effect against a stress agent in epitheli

67 ith the microwave system showed an increased cytoprotective effect against H2O2 induced oxidation in

68 the molecular mechanisms by which FL exert a cytoprotective effect against oxidative stress in tert-b

69 The coffee samples exerted a cytoprotective effect against oxidative stress, with imp

70 Activation of IRE-1 RNase function exerts a cytoprotective effect and has been implicated in the pro

71 however Ulva compressa presented the highest cytoprotective effect by blunting the apoptosis process.

72 ely deregulated in cancer cells, mediating a cytoprotective effect during blood-borne metastasis.

73 oneal administration of PC-S195A conferred a cytoprotective effect for thrombin in an in vivo inflamm

74 tivation by IGF-I is crucial to preserve its cytoprotective effect in astrocytes and may form part of

75 into polysomes, mechanistically providing a cytoprotective effect in cells.

76 The cytoprotective effect is dependent on the major HA-recep

77 culum (ER), this study addressed whether the cytoprotective effect of iPLA2gamma involves the ER stre

78 Herein we studied the cytoprotective effect of resveratrol on DEP-exposed huma

79 ISPR-mediated mutagenesis abolishes both the cytoprotective effect of Retro-2 against ricin and its i

80 In this study, the cytoprotective effect of Schisandrin A (Sch A), one of t

81 The cytoprotective effect of tPA required its receptor, LDL

82 The cytoprotective effect of tucuma was evaluated in lymphoc

83 riking lack of cytotoxicity, even exerting a cytoprotective effect on avian cells.

84 data support a model in which H2S exerts its cytoprotective effect on ISR signaling by inducing a tra

85 hage migration inhibitory factor (MIF) has a cytoprotective effect on lung endothelial cells; however

86 e stress after DETA-NO preconditioning; this cytoprotective effect was abolished by the NO scavenger.

87 Importantly, Mfn1 deficiency abrogated IB5's cytoprotective effect.

88 hypoxia/reoxygenation (H/R) stages to exert cytoprotective effects against H/R injury.

89 Importantly, these precursors exhibit cytoprotective effects against hydrogen peroxide-mediate

90 roxidase-mimicking enzyme properties exhibit cytoprotective effects against ROS-mediated damage at ex

91 Moreover, H2S elicits cytoprotective effects against stressors in various cell

92 showed the highest antioxidant activity and cytoprotective effects against tert-butyl hydroperoxide

93 le heat shock protein 70, Hsp72, has broadly cytoprotective effects and improves outcome following st

94 hat RBC-targeted scFv/TM exerts multifaceted cytoprotective effects and may find utility in systemic

95 s, reported to exhibit anti-inflammatory and cytoprotective effects at low concentration.

96 nduces autophagy, which is essential for its cytoprotective effects from yeast to mice.

97 exerts anti-inflammatory, antiapoptotic, and cytoprotective effects in addition to its hematopoietic

98 17-mer, 17-mer[H105A], and 44-mer exhibited cytoprotective effects in cultured retina R28 cells.

99 Whether TNF-alpha also exerts cytoprotective effects in heart failure is not known.

100 r concentrations, STS-E412 provided EPO-like cytoprotective effects in primary neuronal cells and ren

101 n protease activated protein C (aPC) confers cytoprotective effects in various in vitro and in vivo d

102 manifest neurological disease but leaves the cytoprotective effects of acute ISR activation intact.

103 In addition to the cytoprotective effects of APC on endothelial cells, podo

104 This study aimed to investigate the cytoprotective effects of flavonoids, their metabolites

105 The cytoprotective effects of guanabenz (analogs) have been

106 These findings imply the cytoprotective effects of NF-kappaB activation on oligod

107 mplete or partial loss, respectively, of the cytoprotective effects of partial beclin-1 knockdown, in

108 t that NF-kappaB activation accounts for the cytoprotective effects of PERK activation on oligodendro

109 Interestingly, data indicate that the cytoprotective effects of PERK activation on oligodendro

110 The cytoprotective effects of pigment epithelium-derived fac

111 Understanding how EPCR-APC induces cytoprotective effects through activation of PAR1, whose

112 ndicate that similar to APC, thrombin exerts cytoprotective effects via beta-arrestin-2 biased PAR1 s

113 Similar cytoprotective effects were observed after transient shR

114 HGF), a healing factor with regenerative and cytoprotective effects, are associated with inflammatory

115 mediating activated protein C (APC)-induced cytoprotective effects, including antiapoptotic, anti-in

116 ectedly high GluN2B affinity but do not show cytoprotective effects.

117 AR1, but its effects on cells contrast APC's cytoprotective effects.

118 on substrate translocation and abolishes the cytoprotective effects.

119 e propose that polySia in semen represents a cytoprotective element to increase the number of vital s

120 owever, delivery of MSCs in the absence of a cytoprotective environment offers limited efficacy due t

121 s a stress-inducible, anti-inflammatory, and cytoprotective enzyme expressed in most cell types in th

122 Expression of the cytoprotective enzyme heme oxygenase-1 (HO-1) is signifi

123 osine kinase c-Met and overexpression of the cytoprotective enzyme heme oxygenase-1 (HO-1) play a cri

124 KEY POINTS: Haem oxygenase 1 (Hmox1) is a cytoprotective enzyme with anti-inflammatory and anti-ox

125 Heme oxygenase-1 (HO-1), a pivotal cytoprotective enzyme, has antiviral activity for a numb

126 ession of heme oxygenase-1 (HO-1), a pivotal cytoprotective enzyme, postinfection and that overexpres

127 sion of heme oxygenase-1, an antioxidant and cytoprotective enzyme.

128 The mRNA levels of cytoprotective enzymes (NQO1, HO-1, AKR1C1), and heat sh

129 Nrf2, which regulates the expression of many cytoprotective enzymes including heme oxygenase-1 (HO-1)

130 stress signaling increases the expression of cytoprotective ER-chaperones.

131 g not as a trigger of inflammation, but as a cytoprotective factor in the retina.

132 ged mitochondria, increase the production of cytoprotective factors and prevent cell death.

133 The benefits resulted from cytoprotective factors including vascular endothelial gr

134 ure assays, DAR did not stimulate release of cytoprotective factors, such as vascular endothelial gro

135 st marked changes, we found up-regulation of cytoprotective factors; a shift from oxidative phosphory

136 se optimum, the same domain is mitogenic and cytoprotective for epithelia via a syndecan-1 targeting

137 ther the drugs or radiation used promote the cytoprotective form of autophagy in the tumor cells as w

138 53 null H1299 cells but was converted to the cytoprotective form with induction of p53.

139 icoagulant function without compromising its cytoprotective function and offers superior therapeutic

140 tial for mitochondrial turnover and serves a cytoprotective function in dopaminergic neurons in vivo.

141 This cytoprotective function of ATG16L1 was associated with t

142 nogenic rescue; thus, IB5 activated a latent cytoprotective function of PKM2.

143 s alloimmune response towards the graft, the cytoprotective function of these cells on CEnCs has not

144 We further demonstrate that the cytoprotective function of Tregs derived from low-risk h

145 mic mRNA complexes and is sufficient for the cytoprotective function of TSN during stress.

146 Furthermore, our work connects the cytoprotective function of TSN with its positive role in

147 One is the cytoprotective function that can in theory be inhibited

148 o large aggregates and is believed to have a cytoprotective function.

149 activities, whereas type II preserves APC's cytoprotective function.

150 ion factor well known for its cell-intrinsic cytoprotective function.

151 pe digestive epithelia and provide important cytoprotective function.

152 that might have significant implications for cytoprotective functions and therapeutic targeting of th

153 MDP cytoprotective functions are generally attributed to ant

154 he integrated stress response (ISR) that has cytoprotective functions as well as apoptotic signals th

155 cytosolic isoforms of SKN-1 perform distinct cytoprotective functions corresponding to those of mamma

156 nism of the signaling pathways mediating the cytoprotective functions of H2S is not well understood.

157 2 transcription factor is well known for its cytoprotective functions through regulation of genes inv

158 asma serine protease with antithrombotic and cytoprotective functions.

159 s a transcription factor that is crucial for cytoprotective gene expression and is generally thought

160 nstressed adult mouse hepatocytes produces a cytoprotective gene expression profile and induces lipog

161 vated activation of Nrf2 and upregulation of cytoprotective gene expression.

162 ession of injury markers Kim-1, p21, and the cytoprotective gene heme oxygenase-1 accompanied this.

163 n as NF-E2-related factor 2 (Nrf2), is a key cytoprotective gene that regulates critical antioxidant

164 In summary, fish-derived omega-3s increase cytoprotective genes and decrease proapoptotic genes, im

165 ro-oxidant, tBHQ regulates the expression of cytoprotective genes by activation of redox-sensing tran

166 regulator that promotes the transcription of cytoprotective genes in response to oxidative/electrophi

167 SKN-1/Nrf transcription factors activate cytoprotective genes in response to reactive small molec

168 species (ROS) that lead to the induction of cytoprotective genes such as the UDP-glucuronosyltransfe

169 ttractive possibility is the exploitation of cytoprotective genes that exist solely for self-preserva

170 has been considered as a master regulator of cytoprotective genes, and exists in many cell types incl

171 er cells provokes NRF2-mediated induction of cytoprotective genes, because it logjams the ubiquitin l

172 Instead, ATF4 activates the expression of cytoprotective genes, which reprogram cellular metabolis

173 by inducing the transcription of an array of cytoprotective genes.

174 responds by activating the transcription of cytoprotective genes.

175 idative stress by the regulation of multiple cytoprotective genes.

176 nvolved in the activation of antioxidant and cytoprotective genes.

177 by increasing the expression of a number of cytoprotective genes.

178 e release and thereby allow the induction of cytoprotective genes.

179 n expression and increased the expression of cytoprotective H-ferritin.

180 ich also led to suppressed expression of the cytoprotective heat shock protein 72.

181 tional responses, controls the expression of cytoprotective heat shock proteins (HSPs), molecular cha

182 es (2-37) and compared their cytotoxicity to cytoprotective heat-shock-inducing activity (HSA).

183 enoprotection corresponded with increases in cytoprotective heme oxygenase 1 and IL-10 mRNAs, selecti

184 t, whereas low-concentration thrombin may be cytoprotective, higher thrombin concentrations may contr

185 d in an increase in the transcription of the cytoprotective Hmox1 and pro-inflammatory genes Il1b and

186 it was associated with the overexpression of cytoprotective HO-1 and anti-apoptotic Bcl-2/Bcl-xL.

187 oxide (NO), a gaseous messenger known to be cytoprotective; however, the underlying mechanism remain

188 , this is caused by compromised secretion of cytoprotective IL-18 from IKKalpha-mutant intestinal epi

189 nt tumors, the autophagy is not of necessity cytoprotective in function.

190 trongly suggests that chaperone proteins are cytoprotective in neurodegenerative proteinopathies invo

191 We conclude that eIF2alpha-P is cytoprotective in response to UVB by a mechanism featuri

192 is lethal when exposure is extreme but also cytoprotective in that sublethal exposure leads to the s

193 2 p45-related factor 2 (Nrf2) orchestrates a cytoprotective inducible program, which counteracts the

194 ce, suppresses toxic inflammation, increases cytoprotective insulin-like growth factor 1 (IGF1) signa

195 urodegeneration and that the balance between cytoprotective JNK and cytotoxic p38 signaling dictates

196 ation, and also enhanced the accumulation of cytoprotective markers.

197 ugh binding to the 3'UTR constitutes a novel cytoprotective mechanism of Hsp27 during stress in neuro

198 and suppression of inflammation underlie the cytoprotective mechanism of Nrf2 activators, including b

199 cellular oxidative stress, and its potential cytoprotective mechanism was partially elucidated.

200 erated by pathological stress, possibly as a cytoprotective mechanism.

201 of antioxidant, anti-inflammatory, and other cytoprotective mechanisms important in protection from k

202 e transfer is sufficient to recapitulate the cytoprotective mechanisms in CD31(-) pancreatic beta cel

203 ans shortens lifespan and inhibits conserved cytoprotective mechanisms.

204 suggest that we have discovered a conserved cytoprotective modifier of amyloidogenic processes.

205 gulates the transcription of several hundred cytoprotective molecules, including antioxidants, detoxi

206 preparation, RSSH-releasing properties, and cytoprotective nature of alkylamine-substituted perthioc

207 idated, Plin5 provides a basis for the novel cytoprotective nature of lipid droplets.

208 but at lower concentrations it shows a more cytoprotective nature.

209 ox and metabolic disorder, we found that the cytoprotective nuclear factor erythroid-related factor 2

210 tion of clotting factors Va and VIIIa; (2) a cytoprotective on the basis of endothelial barrier stabi

211 at radiation-induced autophagy can be either cytoprotective or nonprotective, a functional difference

212 s, ubiquitously expressed Mdm2 might enhance cytoprotective parkin activity.

213 The unfolded protein response (UPR) is a cytoprotective pathway that relieves endoplasmic reticul

214 hat CDK20 positively modulate the KEAP1-NRF2 cytoprotective pathway to regulate tumor progression and

215 Our study establishes Nrf2/Keap1 as a cytoprotective pathway, as well as a metabolic rheostat,

216 Both cytoprotective pathways have been well studied in isolat

217 rrier function and induces proliferative and cytoprotective pathways in the small bowel.

218 cross-regulatory network of stress-activated cytoprotective pathways, linking calcium, JNK, Nrf2, and

219 block pathologic signaling while preserving cytoprotective pathways.

220 tional factor that induces antioxidative and cytoprotective pathways.

221 In this study, strong antioxidant and cytoprotective peptides were obtained from a low-cost da

222 , acellular, non-coagulative, echogenic, and cytoprotective perfusate that promotes recovery from ano

223 ghest antioxidant activity were screened for cytoprotective potential in MCF-7 cells, including the m

224 tivity may not be directly related with high cytoprotective potential.

225 long-lasting activation of highly conserved cytoprotective processes(1-3).

226 nfolded protein response (UPR), an important cytoprotective program induced by hypoxia, affects the b

227 we show that vHMM-HA (>6.1 MDa) has superior cytoprotective properties compared to the shorter HMM-HA

228 aglines, which exhibit anti-inflammatory and cytoprotective properties in intestinal epithelial cells

229 Nitric oxide (NO) has demonstrated cytoprotective properties in various cells, but its bene

230 reclinical data showing strong antiviral and cytoprotective properties of alisporivir in various mode

231 of aerobic respiration, and the demonstrated cytoprotective properties of some nitroxides, we probed

232 polyphenols, and to evaluate antioxidant and cytoprotective properties of the partridgeberry polyphen

233 trypsin-like protease with anticoagulant and cytoprotective properties that is generated by thrombin

234 iPSC-derived EVs impart cytoprotective properties to cardiac cells in vitro and

235 9/230 replaced with 2 alanines]) with normal cytoprotective properties, but greatly reduced anticoagu

236 GRP78, a multifunctional protein with potent cytoprotective properties, is an emerging therapeutic ta

237 rapeutics with primary anti-inflammatory and cytoprotective properties, which have less impact on hem

238 AE) were evaluated for their antioxidant and cytoprotective properties.

239 n miRNAs and proteins with proangiogenic and cytoprotective properties.

240 ell maintenance mechanisms of autophagy, the cytoprotective protein alphaKlotho, and the lesser known

241 nstrate a corresponding up-regulation of the cytoprotective protein heme oxygenase-1 (HO-1) which is

242 alphaKlotho is a cytoprotective protein, the expression of which is reduc

243 ated factor (Nrf2) induces the expression of cytoprotective proteins that maintain and restore redox

244 s, governing the expression of more than 200 cytoprotective proteins, including a panel of antioxidan

245 e subpopulations can be modulated to mediate cytoprotective, reparative, and even regenerative functi

246 ring tissues have therefore evolved powerful cytoprotective "resilience" machinery to protect against

247 ches, we demonstrate that HIPK2 can elicit a cytoprotective response in cancer cells via NRF2.

248 Previously, we had shown that this conserved cytoprotective response is regulated by the thermosensor

249 The KEAP1-NRF2-mediated cytoprotective response plays a key role in cellular hom

250 of bixin derived from induction of the NRF2 cytoprotective response since it was only observed in Nr

251 pel-like factor 1 (KLF-1) as a mediator of a cytoprotective response that dictates longevity induced

252 sion in the liver produces a Notch-dependent cytoprotective response through direct transcriptional a

253 SG formation is a cytoprotective response to environmental stress and resu

254 P1 is the key regulator of the NRF2-mediated cytoprotective response, and increasingly recognized as

255 Nrf2 transcription factor is crucial for cytoprotective response, whereas Keap1-an endogenous inh

256 g oxidative stress and, as such, represent a cytoprotective response.

257 ap1-binding motif and fails to activate this cytoprotective response.

258 factor, plays a crucial role in adaptive and cytoprotective responses in cells and is involved in cel

259 unexpected interaction between two important cytoprotective responses that are likely to have signifi

260 coordinately regulates basal metabolism and cytoprotective responses to radiation injury.

261 Foci may serve as sensors that tune cytoprotective responses, balancing rapid transient resp

262 f TCF7 in human and mouse islets impairs the cytoprotective responsiveness to GIP and enhances the ma

263 induced hepatic lipophagy plays an important cytoprotective role against liver injury, but its mechan

264 Analogous to its established cytoprotective role during nutrient starvation, autophag

265 Here, we reveal a cytoprotective role for mitochondrial ROS (mtROS) in Cae

266 These data suggest a cytoprotective role for Plin5 to promote lipid storage b

267 While UPF1 is best known for its basal cytoprotective role in degrading aberrant RNAs, UPF1 als

268 findings, we concluded that Sch A exerted a cytoprotective role in DON-induced toxicity in vitro, an

269 MiR-150 conferred a cytoprotective role in lung epithelial cells after oxida

270 n the kidney during endotoxemia and served a cytoprotective role in mitigating acute kidney injury.

271 bound transcription factor ATF6alpha plays a cytoprotective role in the unfolded protein response (UP

272 The cytoprotective secretory form of clusterin, as evaluated

273 (TRAF2), an E3 ubiquitin ligase, coordinates cytoprotective signaling downstream of both TNF receptor

274 otential of novel APC variants with superior cytoprotective signaling function as enhanced therapeuti

275 hat block proinflammatory pathways but spare cytoprotective signaling in endothelial cells.

276 Our results suggest that H2S-mediated cytoprotective signaling in the setting of I/R injury is

277 This study elucidated a novel cytoprotective signaling pathway initiated by the APP tr

278 vokes the unfolded protein response (UPR), a cytoprotective signaling pathway.

279 elopment and function and promotes cell-cell cytoprotective signaling responses.

280 APC elicits cytoprotective signaling through activation of protease

281 at a cleavage site that selectively mediates cytoprotective signaling.

282 effector, which contributes to TRAF2-induced cytoprotective signaling.

283 by crosstalking with c-Met to potentiate its cytoprotective signals in airway epithelial cells during

284 ponse to influenza infection by facilitating cytoprotective signals through c-Met signaling to limit

285 Safe, cytoprotective strategies are needed to reduce this risk

286 ession in beta-cells should be explored as a cytoprotective strategy in type 1 diabetes.

287 sis in the presence of stromal co-culture or cytoprotective survival signals.

288 FLT3 is a cytoprotective system in the heart and a potential thera

289 cies (ROS) production and the ability of the cytoprotective system to detoxify the reactive intermedi

290 aracterised by the upregulated expression of cytoprotective target genes.

291 target for a first-in-class mechanism-based, cytoprotective therapy in the unmet high medical need in

292 Here we show that ER-localized THBS1 is cytoprotective to rat, mouse, and human beta-cells expos

293 Here we demonstrate that the key cytoprotective transcription factor NRF2 controls lncRNA

294 tified novel crosstalk between HIPK2 and the cytoprotective transcription factor NRF2.

295 eic acid and is coupled to activation of the cytoprotective transcription factor SKN-1 in both labora

296 e demonstrate genetic ablation of the master cytoprotective transcription factor, nuclear factor (ery

297 its splicing target, bZIP60, govern the two cytoprotective UPR signaling pathways known to date.

298 cetin) and quercetin have shown antioxidant, cytoprotective, vasoprotective, antiproliferative and an

299 Whether DAR was directly cytoprotective was examined in cultured rat hepatocytes

300 of ubiquitin-tagged damaged mitochondria is cytoprotective, we tested the hypothesis that TRAF2 medi