ライフサイエンスコーパス: cytosine residue

1 tosine residues are replaced with unmodified cytosine residues).

2 tein and a phosphate two bases away from the cytosine residue.

3 fts methylation exclusively to the mispaired cytosine residue.

4 sence of the C-5 methyl group at neighboring cytosine residues.

5 s caused by APOBEC3-catalyzed deamination of cytosine residues.

6 ith templates incorporating atactic glyceryl cytosine residues.

7 ed by sequences that are rich in guanine and cytosine residues.

8 causing them to become stably methylated at cytosine residues.

9 ntact with the methyl-groups of the modified cytosine residues.

10 ects of the interaction between two adjacent cytosine residues.

11 DNA methylation at selective cytosine residues (5-methylcytosine (5mC)) and their rem

12 ty may relate to repair of oxidized 5-methyl cytosine residues (5meCyt).

13 these codons leading to translation of more cytosine residues: a shift that leads to more proline, a

14 ch contains glucosylated, 5-hydoxymethylated cytosine residues, affects the ability of particular Mot

15 proteins involved in the modification of DNA cytosine residues and enzymes which catalyze posttransla

16 otide substrate contains three C5-methylated cytosine residues and one unmethylated 5'-CG-3' site.

17 l-L-methionine (AdoMet) to the 5-position of cytosine residues and thereby silence transcription of r

18 Eukaryotic DNA is methylated at some cytosine residues, and this epigenetic feature performs

19 spectra in H2O showed that the third strand cytosine residues are fully paired with the guanine resi

20 histones and methylation of histones and DNA cytosine residues are part of the complex epigenetic reg

21 J CH) conclusively showed that the Hoogsteen cytosine residues are protonated at N3.

22 nd how methylated and unmethylated states of cytosine residues are transmitted during DNA replication

23 expression in mammals through methylation of cytosine residues at CpG dinucleotides is involved in th

24 The specificity of the reaction of cytosine residues at ss- versus dsDNA loci after endonuc

25 system was likely to be 5' GATC 3', with the cytosine residue being modified to 5-methylcytosine.

26 ellite DNA is normally heavily methylated at cytosine residues, but in ICF syndrome it is almost comp

27 CpG site could affect the methylation of the cytosine residue by both methyltransferases and the effe

28 he Watson-Crick face of unpaired adenine and cytosine residues by dimethyl sulfate, result in a stop

29 ic analyses have suggested that a particular cytosine residue (C(75)) with a pK(a) close to neutralit

30 ve structure with protonation of the crucial cytosine residue, C8(N3+).

31 DNA fragments with stretches of cytosine residues can fold into four-stranded structures

32 specific contacts between ppGpp and specific cytosine residues during both transcription initiation a

33 NA is drastically remodeled, with the target cytosine residue extruded from the DNA helix and plunged

34 th were poor targets for A3G activity unless cytosine residues flanked the cytosine dinucleotide.

35 vidual sites highlighted the importance of a cytosine residue flanking the core CSL binding sequence.

36 single methyl group at the 5-position of the cytosine residue flanking the lesion on the 5'-side, is

37 spots is enhanced by the methylation of the cytosine residue flanking the target guanine residue on

38 DMS), which reacts with unpaired adenine and cytosine residues, followed by deep sequencing to monito

39 t brain is to remethylate newly incorporated cytosine residues from G.T mismatch repair after deamina

40 ty of DNA duplexes bearing isolated glyceryl cytosine residues has also been investigated.

41 The cytosine residue immediately 5' to the cleavage site for

42 Partially methylated cytosine residues in 13.5 d.p.c. embryos and undifferent

43 Further investigation revealed that the cytosine residues in a CpG cluster in the promoter regio

44 ression levels correlated with the number of cytosine residues in a string of cytosines located close

45 RIP is often associated with methylation of cytosine residues in and around the mutated sequences.

46 ponsible for de novo methylation of specific cytosine residues in CpG dinucleotides during mammalian

47 Methylation of cytosine residues in CpG dinucleotides is generally asso

48 Methylation of cytosine residues in CpG dinucleotides plays an importan

49 Epigenetic modifications of cytosine residues in DNA and the amino termini of histon

50 Epigenetic methylation of cytosine residues in DNA is an essential element of geno

51 ups from S-adenosyl-l-methionine (AdoMet) to cytosine residues in DNA is the transient formation of a

52 bisulphite sequencing we mapped the methyl- cytosine residues in DNA methylated in vitro and in vivo

53 pairs and is triggered by the deamination of cytosine residues in DNA to uracil; phase 2 affects most

54 Methylation of cytosine residues in DNA, the best studied epigenetic mo

55 the model that AID functions by deaminating cytosine residues in DNA.

56 se (Dnmt)-catalyzed methyl group transfer to cytosine residues in gene-regulatory regions.

57 by the transcription-coupled deamination of cytosine residues in Ig genes.

58 d somatic hypermutation (SHM) by deaminating cytosine residues in immunoglobulin genes (Igh, Igkappa,

59 AID) initiates both processes by deaminating cytosine residues in immunoglobulin genes.

60 Cytosine residues in mammalian DNA occur in at least thr

61 Cytosine residues in mammalian DNA occur in five forms:

62 ly of enzymes responsible for methylation of cytosine residues in mammals.

63 ine, and cytidine 5'-phosphate, and also for cytosine residues in single-stranded DNA generated from

64 ass tagging, involves the labeling of target cytosine residues in synthetic DNA duplexes with stable

65 cally, it can react with distant thymine and cytosine residues in the chain, forming fluorescent and

66 ted to spontaneous deamination of methylated cytosine residues in the colon and small intestine, prob

67 group of adenine or the N(4)-amino group of cytosine residues in the complementary strand under phys

68 restrict retroviral infection by deaminating cytosine residues in the first cDNA strand of a replicat

69 amolecular DNA triple helix possessing three cytosine residues in the Hoogsteen strand (1) and a disu

70 a and base pairing characteristics as native cytosine residues in the human telomeric repeat sequence

71 is extremely sensitive to methylation of the cytosine residues in the invariant CpG half-site core, s

72 EC 2.1.1.37) maintain patterns of methylated cytosine residues in the mammalian genome; faithful main

73 ewly synthesized strand does not contain any cytosine residues in the recognition sequence.

74 Cytosine residues in the sequence 5'CpG (cytosine-guanin

75 tly of the S type, except for the protonated cytosine residues in the third strand which show hybrid

76 Cytosine residues in the vertebrate genome are enzymatic

77 At least 12 of the cytosine residues in this region are exclusively methyla

78 s and RNA-directed DNA methylation (RdDM) at cytosine residues in three DNA sequence contexts (CG, CH

79 be responsible for the repair of deaminated cytosine residues in vivo.

80 ignment displaced along with the 5'-flanking cytosine residue into the major groove.

81 lesions in a DNA template, providing that a cytosine residue is incorporated opposite anti-BPDE-modi

82 o acid long peptide with C-terminal modified cytosine residue is produced.

83 yotic DNA by methylation of the 5' carbon of cytosine residues is frequently associated with transcri

84 fer of the shared proton between the 2AP and cytosine residues is indicated by the rapid exchange of

85 The pK of terminal cytosine residues is much lower, in the range 6.2 to 7.2

86 Specific recognition of the three cytosine residues is realized by a dense network of hydr

87 hermore, removal of the Watson-Crick partner cytosine residue (leaving an abasic site) in the complem

88 utation is due to (i) the amino group of the cytosine residue making an intra-RNA hydrogen bond that

89 as histone acetylation and methylation, and cytosine residue methylation in CpG dinucleotides, have

90 vocally showed that the pK of the protonated cytosine residue must be at least 9.5 for internal posit

91 m was located in the C5 position of a single cytosine residue of an oligonucleotide designed to form

92 aceum, the targets for RIP mutations are the cytosine residues of TCG trinucleotide combinations.

93 We show that the cytosine residues of the Hoogsteen C+.G pairs in this tr

94 on of protonation at the N3 of the Hoogsteen cytosine residue on the stability of various sequences o

95 ic sites, apyrimidinic sites, and deaminated cytosine residues on human topoisomerase IIalpha were as

96 methylation at both symmetric and asymmetric cytosine residues on the MITE sequences, possibly induce

97 te group linking U5 and U6, which favors the cytosine residue over uracil by about 6.0 kcal/mol.

98 DNA methylation in cytosine residues plays an important role in regulating

99 irpin aligned as d(GCC).d(GCC) with unpaired cytosine residues possibly turned outwards and stacked i

100 hrough unconventional hydroxy-methylation of cytosine residues present in introns.

101 igh chi angle (> -80 degrees) for the target cytosine residue reduces the distances for both SG-C6 an

102 s 544 RNA-directed DNA methylation (RdDM) at cytosine residues regulates gene expression, silences tr

103 Residual unconverted cytosine residues shared many attributes with bisulfite

104 e fimN promoter region contains a stretch of cytosine residues similar in length to those of other fi

105 the alignment d(CCG).d(CCG) with mismatched cytosine residues stacked into the helix but with 15 or

106 high frequency of C-->G transversions at the cytosine residues targeted by both enzymes, allowing ide

107 o a syn conformation, pairing to its counter cytosine residue that is protonated at pH 5.9.

108 d-type, which contains a modification of the cytosine residues that projects into the major groove: a

109 quences of 33 nt with or without symmetrical cytosine residues, the methylation was distributed throu

110 sis to understand the effect of mutating the cytosine residue to uracil on the thermodynamic stabilit

111 Posttranscriptional methylation of RNA cytosine residues to 5-methylcytosine (m(5)C) is an impo

112 ade use of site-specific 15N-labeling of the cytosine residues to investigate their protonation statu

113 ion-induced cytidine deaminase that converts cytosine residues to uracils in a transcription-dependen

114 proton sources for protonation of N3 of the cytosine residue upon formation of the covalent intermed

115 enrich for DNA fragments carrying deaminated cytosine residues, we were able to sequence 70 and 0.4 m

116 Epigenetic changes in several cytosine residues were detected in a fragment of 4,700 b

117 The sugar conformations of the two adjacent cytosine residues were different and the 5'-residue was

118 Methyl-cytosine residues were observed in multiple sequence con

119 However, methylation of RNA cytosine residues, which would drive another level of bi

120 dine sequence by substitution of 5 of the 23 cytosine residues with adenine prevented triple helix fo

121 a) mRNA via DNA hypermethylation at a single cytosine residue within its promoter.

122 ing multiple methylated or hydroxymethylated cytosine residues within a short recognition sequence (G

123 Cytosine residues within CpG dinucleotides at the enhanc

124 Across vertebrate genomes methylation of cytosine residues within the context of CpG dinucleotide