ライフサイエンスコーパス: cytosol

1 ies muscle conditions that increase [Ca(2+)](cytosol).

2 ficient synthesis of target compounds in the cytosol.

3 vesicle and would allow export of RNA to the cytosol.

4 nd maximize access to the nutritionally rich cytosol.

5 ies they use to gain access to the host cell cytosol.

6 OX2 activity in phagosomes and escape to the cytosol.

7 solution permits transcript reentry into the cytosol.

8 om hundreds of proteins within the bacterial cytosol.

9 d then posttranslationally imported from the cytosol.

10 ulated differently in the nucleus and in the cytosol.

11 plications of proteins require access to the cytosol.

12 rotubule nucleation in vitro and in isolated cytosol.

13 the association of Gag with the gRNA in the cytosol.

14 e calcium binding proteins are lost from the cytosol.

15 to and disassemble SV40 upon arrival to the cytosol.

16 cally inactive precursor pro-IL-1beta in the cytosol.

17 creatine kinase without ATP dilution in the cytosol.

18 embrane, and delivers the AC enzyme into the cytosol.

19 granuphilin from the plasma membrane to the cytosol.

20 ectin-8, indicating bacterial entry into the cytosol.

21 ve inside a vacuole that resides in the host cytosol.

22 e directly into both the chloroplast and the cytosol.

23 ytic carriers and for their capture into the cytosol.

24 become misfolded in the context of a crowded cytosol.

25 duction pathway between the lower cavity and cytosol.

26 tantial variability in the properties of the cytosol.

27 therefore imports all of its tRNAs from the cytosol.

28 e cells and deliver the AC enzyme into their cytosol.

29 for neoxanthin synthesis takes place in the cytosol.

30 erpolarization and conducts protons into the cytosol.

31 gnificantly lower in the nucleus than in the cytosol.

32 inor fraction of protein mislocalized to the cytosol.

33 lease of nascent ribosomal proteins into the cytosol.

34 ria access to their replicative niche in the cytosol.

35 microtubule nucleation activity in isolated cytosol.

36 DAC1, the channel that releases ATP into the cytosol.

37 for the clearance of DNA and viruses in the cytosol.

38 mbrane-spanning translocon pore to reach the cytosol.

39 on of the gRNA from the capsid into the host cytosol.

40 es in response to foreign DNA species in the cytosol.

41 e it can be largely rescued by normal oocyte cytosol.

42 and the complete pathway is localized in the cytosol.

43 cross talk between the mitochondria and the cytosol.

44 steria and inhibits their replication in the cytosol.

45 fficient (>=90%) delivery of proteins to the cytosol.

46 calmodulin-binding site for retention in the cytosol.

47 elope separating plastid metabolism from the cytosol.

48 oxicity in cancer cells upon delivery to the cytosol.

49 Ag VLPs to the HIV capsid protein P24 in the cytosol.

50 nucleoprotein export from the nucleus to the cytosol.

51 PMPs and hydrocarbon-stapled peptides to the cytosol.

52 ase (cGAS), despite its presence in the cell cytosol.

53 tes clearance of misfolded proteins from the cytosol.

54 ory peptidoglycan fragments in the host cell cytosol.

55 somes import their luminal proteins from the cytosol.

56 nuclear genes and must be imported from the cytosol.

57 n and trehalose to vary the viscosity of the cytosol.

58 ome while repressing it during growth in the cytosol.

59 apoptosis by releasing cytochrome c into the cytosol.

60 t export iron from the mitochondria into the cytosol.

61 s a proton inward current that acidifies the cytosol.

62 hat pump anti-cancer therapeutics out of the cytosol.

63 ents HSV-1 capsids from penetrating into the cytosol.

64 fy the variations of NO(3) (-) and pH in the cytosol.

65 and revealed that the active site faces the cytosol.

66 chaperones and the proteasome system in the cytosol.

67 scriptionally active reovirus cores into the cytosol.

68 sport deficit and accumulation of Ran in the cytosol.

69 by the nuclear genome and translated in the cytosol.

70 ates the transport of ERAD substrates to the cytosol.

71 l and ends when the viral contents reach the cytosol.

72 the cell membrane and diffuse throughout the cytosol.

73 n SMCs and the subsequent leak of DNA to the cytosol activated STING signaling, which induced cell de

74 eration in glucose metabolism: high [Ca(2+)](cytosol) activates PhK, which inhibits GS, activates GP

75 ith increased release of cytochrome c to the cytosol, activation of caspase-3, and lactate dehydrogen

76 the pathway encoded by Shigella flexneri, a cytosol-adapted bacterium, provide compelling evolutiona

77 y Ras activator that is autoinhibited in the cytosol and activates upon membrane recruitment.

78 cket that alternately faced the ER lumen and cytosol and an endogenous substrate resembling an alpha-

79 protein fusions of BdXFUC1 localized to the cytosol and both proteins lack a signal peptide.

80 dark-induced increases in Ca(2+) in both the cytosol and chloroplasts are gated by the nuclear circad

81 g circadian oscillations of [Ca(2+) ] in the cytosol and chloroplasts.

82 these defects promote mtDNA leakage into the cytosol and chronic cGAS engagement.

83 VIG1 localizes predominantly in the cytosol and comigrates with monoribosomes and polyriboso

84 doplasmic reticulum (ER) are returned to the cytosol and destroyed by a process known as ER-associate

85 d be successfully conjugated with GFP in the cytosol and ER without altering VLP formation or GFP flu

86 ion of PKC at the plasma membrane and in the cytosol and ERK in the nucleus.

87 ier for pathogen effectors to reach the host cytosol and for the acquisition of host-derived nutrient

88 reatment disrupted CTA1 translocation to the cytosol and generated a toxin-resistant phenotype.

89 tion where pre-systolic calcium level in the cytosol and in the SR must fulfill simultaneously two di

90 are RNA sensors that detect viral RNA in the cytosol and induce an IFN-I response.

91 RIG-I senses viral RNA in the cytosol and initiates host innate immune response by tri

92 ve been widely used to monitor Zn(2+) in the cytosol and intracellular organelles.

93 BCAP is exclusively localized in the cytosol and is unable to bind DNA.

94 the mechanisms of self-DNA release into the cytosol and its role in inflammatory tissue injury are n

95 by ENGase and mannosidase processing in the cytosol and lysosomes.

96 major channels of communication between the cytosol and mitochondria and are indispensable for cellu

97 onsistently, sustained JNK activation in the cytosol and mitochondria from hepatocytes were also decr

98 TX and PTX bound to plant SHMT isozymes from cytosol and mitochondria-human isozymes exist in the sam

99 ch regulates the NAD+/NADH ratio between the cytosol and mitochondria.

100 calized protein that distributes between the cytosol and mitochondria.

101 drug Eflornithine impairs the ability of the cytosol and mitochondrion to cope with exogenous oxidati

102 indicating that TbCAE is located both in the cytosol and mitochondrion.

103 extracellular vesicles increased transfer of cytosol and Nef protein to endothelial monolayers in a R

104 sport or diffusion of Fyn kinase between the cytosol and nucleus in the cells, which is important for

105 partments, we show that cAMP produced in the cytosol and nucleus stimulates proliferation in thyroid

106 ncrease calcium concentration in the somatic cytosol and nucleus, and these calcium responses invade

107 The heat shock response (HSR) in the cytosol and nucleus, as well as the unfolded protein res

108 esponding phosphatases are maintained in the cytosol and nucleus, we further engineered a Fyn kinase

109 ts a variety of actin-based functions in the cytosol and nucleus.

110 (1D)-AR is widely distributed throughout the cytosol and nucleus.

111 s) and glutathione (GSH) are abundant in the cytosol and nucleus.

112 at Ser-637 (Drp1(pS637)) resides both in the cytosol and on mitochondria.

113 with concomitantly inefficient access to the cytosol and other organelles, including the nucleus.

114 the majority of YAP to translocate into the cytosol and reduced YAP/TAZ protein levels.

115 mes as portals for passing proteins into the cytosol and suggest that this environment is prerequisit

116 sufficient, it is retrotranslocated into the cytosol and targeted for destruction by the ER--associat

117 ly acting Nat, AtNAA50-EYFP localized to the cytosol and the endoplasmic reticulum but also to the nu

118 phorylation switch that shuttles between the cytosol and the nucleus, a strategy that should be gener

119 ariants, like wild-type Drp1, located to the cytosol and to mitochondria and rescued a Drp1 deficienc

120 thases are found in the plastids, one in the cytosol and two in the mitochondria.

121 els that mediate the back-leak of Na(+) into cytosol and, if not regulated tightly, could result in a

122 budding lipid membranes elongating into the cytosol and/or membrane segments migrating there and eve

123 ainly in plastids), PAPS consumption (in the cytosol), and PAP (the stress signaling molecule 3'-phos

124 an extensive interplay between the nucleus, cytosol, and chloroplasts, involving regulatory nucleus-

125 envelope disruption, leakage of DNA into the cytosol, and eventual necroptosis.

126 psids were released from the nuclei into the cytosol, and fewer infectious virions were assembled.

127 eract with ABA receptors at plasma membrane, cytosol, and nucleus, targeting them for degradation via

128 artments of the cell, such as endosomes, the cytosol, and the nucleus.

129 Measurements of the material state of the cytosol are challenging due to its spatial and temporal

130 ial structure and physical properties of the cytosol are not well understood.

131 site couples two decisive infection events, cytosol arrival and disassembly, and suggest cargo remod

132 e compounds in microorganisms mostly use the cytosol as a general reaction vessel.

133 ent from the cytosol, becomes exposed to the cytosol as an early predictive marker of BCV rupture by

134 lux" back to the reducing environment of the cytosol as intact, folded proteins.

135 metal ion changes its oxidation state in the cytosol as V does, unstable complexes in the extracellul

136 ing that HRI may control proteostasis in the cytosol at least in part through chaperone-assisted sele

137 oparticles (GEMs) has opened up study of the cytosol at the length scales of multiprotein complexes (

138 ve bacterial pathogens that inhabit the host cytosol avoid inflammasomes(1-6) and are often insensiti

139 BCV membranes, and normally absent from the cytosol, becomes exposed to the cytosol as an early pred

140 synthesized TA protein is shielded from the cytosol by a pretargeting complex and an ATPase that del

141 In contrast, the detection of DNA in the cytosol by AIM2 assembles a macromolecular complex calle

142 onounced at membrane segments exposed to the cytosol by ruptures.

143 ade antimicrobial autophagy in the host cell cytosol by unknown mechanisms.

144 enzymes that generate Cu(I) in the bacterial cytosol by using [4Fe-4S] clusters.

145 3), and by proteins that bind calcium in the cytosol (calbindin).

146 n a crowded and heterogeneous environment of cytosol can be greatly facilitated.

147 d 212 metabolites within three compartments: cytosol, chloroplast and mitochondrion.

148 xin (TRX) and reduced GSH/GRX systems of the cytosol, chloroplasts, mitochondria and nucleus, we have

149 ular vesicles define lipid bilayer-enclosed, cytosol-containing spheres that, when released by plants

150 The eukaryotic cytosol contains multiple RNP granules, including P-bodi

151 picomplexans parasitize within the host cell cytosols, Cryptosporidium resides on top of host cells,

152 We have reported that once in the cytosol, cytochrome c is targeted for degradation by the

153 ing exosome was due to the receptor-mediated cytosol delivery of the siRNA payload without endosome t

154 n through an electrophoretic process without cytosol dilution.

155 olyomavirus SV40 escapes the ER to reach the cytosol en route to infection.

156 dependent degradation, were decreased in the cytosol-enriched fraction of SZ subjects.

157 ve inhibitor binding to the Neu5Ac site in a cytosol-facing conformation.

158 In the cytosol, FAK adopts an autoinhibited state but is activa

159 ce of functional compartmentalization of the cytosol for both the nuclear division cycle and branchin

160 d dsRNA from endocytic compartments into the cytosol for innate immune activation, but the role of SI

161 mammalian cells and remain functional in the cytosol for live-cell labeling, highlighting their poten

162 its internalization vacuole and reaches the cytosol for replication.

163 ely results in the release of cyt c into the cytosol for the engagement of apoptosis.

164 at operate through a common compartment, the cytosol for transport at the plasma membrane and tonopla

165 eral transfer events detected no transfer of cytosol from donor-to-acceptor mouse macrophages.

166 on pathways in the endoplasmic reticulum and cytosol have led to the prevailing idea that these pathw

167 by endocytosis and transports them into the cytosol, highlighting a role for endolysosomes in the up

168 GFP fluorescence builds up within the cell cytosol in 60 min, demonstrating Cupid-GFP has permeated

169 ein triggers translocation of mtDNA into the cytosol in a MAVS-dependent manner.

170 teins exhibit a dual location, namely in the cytosol in addition to their association to plastids (wh

171 ty and specific uptake of the probe into the cytosol in breast cancer cell lines.

172 plasmic reticulum (ER) membrane to enter the cytosol in order to promote infection.

173 released from endolysosomal vesicles to the cytosol in primary hippocampal neurons through the TRPML

174 SH3 reversibly exits from the nucleus to the cytosol in response to the proinflammatory cytokine inte

175 In contrast, Rad23 is localized in the cytosol in rna1-1, a nucleocytoplasmic transport mutant,

176 olecular condensation is a way of organizing cytosol in which proteins and nucleic acids coassemble i

177 [Ca(2+)](cytosol), increased to MHS levels, promoted GP phosphory

178 te that IP(3)-mediated Ca(2+) release in the cytosol increases the duty cycle of the Ca(2+) transient

179 cursor overaccumulation stress (mPOS) in the cytosol independent of bioenergetics.

180 mitochondrial and nuclear host DNA into the cytosol, indicating that ESX-1 affects host membrane int

181 One pool accumulates inside the cytosol, inducing the loss of synaptic plasticity potent

182 Strategically localized at the ER-cytosol interface, Ubqln4 captures SV40 emerging from th

183 s 6-59-amino-acid-long polypeptides from the cytosol into lysosomes.

184 sted to induce translocation of FXR from the cytosol into the nucleus, increased the inhibitory effec

185 -type ATPase that transports Ca(2+) from the cytosol into the sarco(endo)plasmic reticulum (SR/ER) lu

186 Active removal of Na(+) from the cytosol into the vacuole plays a critical role in salini

187 lysaccharide sequestered in the membranes of cytosol-invading bacteria activates caspases remains unk

188 In response to cytosol-invading bacteria, activation of caspase-4 throu

189 penetration of the ER membrane to reach the cytosol is a decisive virus infection step.

190 Direct entry to the cytosol is challenging due to the impermeability of the

191 NG2 localized within the cytosol is found to be transported through clathrin and

192 chondrial proteins is saturable and that the cytosol is limited in degrading unimported mitochondrial

193 ty of 2Fe-2S clusters in the chloroplast and cytosol is linked to Fe homeostasis in plants.

194 The long rod facing the cytosol is mainly formed by the predicted coiled-coil do

195 tracellular bacterial DNA into the host cell cytosol is sensed by the cyclic GMP-AMP synthase (cGAS)

196 e that are comparable to models in which the cytosol is treated as an open, empty region.

197 The presence of DNA in the cytosol is usually a sign of microbial infections, which

198 d RNA, across the cell membrane and into the cytosol, is a critical process in both biology and medic

199 In the cytosol, KDM8 associates with PKM2, the gatekeeper of py

200 e uniquely endowed with ClpB proteins in the cytosol, mitochondria and chloroplasts.

201 sembly machineries in plants, located in the cytosol, mitochondria, and chloroplasts.

202 t saponin molecule diffusion, cell geometry, cytosol molecule diffusion, and pore dynamics.

203 cellular signaling mechanisms and enter the cytosol mostly through voltage-gated calcium channels.

204 asome pathway, latent 26S proteasomes in the cytosol must assume an active form.

205 induces calcium responses within the somatic cytosol, nucleus, dendrites, and dendritic spines of lam

206 SP classes encoding proteins targeted to the cytosol, nucleus, endoplasmic reticulum, chloroplasts, m

207 The trajectory of a single protein in the cytosol of a living cell contains information about its

208 f delivering proteins, such as GFP, into the cytosol of a variety of cells.

209 an outer protein layer and delivery into the cytosol of an intact, inner capsid particle (the "double

210 ezomib (BTZ), a proteasome inhibitor, in the cytosol of cancer cells, but rescues the normal cells (n

211 ionally, the delivery of purified LOS to the cytosol of cells increased the levels of the antiapoptot

212 Hg methylation occurs in the cytosol of certain obligate anaerobic bacteria and archa

213 By sequencing mRNA from the nucleus and cytosol of control and TPR-depleted cells, we provide ev

214 d from the xylem and phloem and included the cytosol of damaged cells.

215 les efficiently delivered ovalbumin into the cytosol of dendritic cells and demonstrated enhanced ant

216 d mitochondrial DNA (mtDNA) release into the cytosol of endothelial cells.

217 Pathogenic bacteria enter the cytosol of host cells through uptake into bacteria-conta

218 ects the effector LamA, an amylase, into the cytosol of human macrophage (hMDMs) and amoebae to rapid

219 r 17 (T(H)17) cell differentiation, into the cytosol of IECs in a cell division control protein 42 ho

220 large viral replication compartments in the cytosol of infected cells.

221 We generated an NAD redox atlas of the cytosol of living Arabidopsis seedlings that revealed pr

222 e delivery of a large enzyme, CDTa, into the cytosol of mammalian cells.

223 nition receptors on the membranes and in the cytosol of mammalian cells.

224 rataxin (79-207) is present primarily in the cytosol of mouse liver; whereas, frataxin (78-207) is pr

225 huge cytoskeletal assemblies embedded in the cytosol of muscle cells.

226 el membrane transport system operates in the cytosol of P. falciparum-infected erythrocytes as a chol

227 bnormal TDP-43 aggregates in the nucleus and cytosol of their surviving neurons and glia.

228 Here, we show that the cytosol of yeast cells acidifies modestly in early aging

229 ria from vacuolar compartments into the host cytosol often without overt destruction of the infected

230 are moved from the phospholipid bilayer into cytosol, often together with hydrophilic and folded ER l

231 induced a greater limitation imposed by the cytosol on CO(2) transport, further reducing the photosy

232 , we dialyzed glutamate into the presynaptic cytosol or blocked the vesicular glutamate uptake with b

233 n import can reflect iron transport into the cytosol or mitochondria.

234 roGFP2, roGFP2-hGrx1 or roGFP2 in either the cytosol or mitochondrion of Trypanosoma brucei.

235 that do not seem to deliver the cargo to the cytosol or nucleus.

236 n of the intracellular domain of TrkB in the cytosol or on the plasma membrane is able to induce the

237 opening of IP(3) receptors facing either the cytosol or the ud, and subsequent refilling of the respe

238 whose enzymes localize to the mitochondrion, cytosol, or apicoplast, a nonphotosynthetic plastid pres

239 regates, and (v) localization of aggregates (cytosol, perinuclear, or nuclear).

240 of Toxoplasma DNA or bacterial LPS into the cytosol, pointing to its role in liberating microbial mo

241 ERAD-L): They are retrotranslocated into the cytosol, polyubiquitinated, and degraded by the proteaso

242 o 30% of the glutamine is metabolized in the cytosol, primarily for nucleotide synthesis, producing c

243 ed that this transcript was localized in the cytosol, prompting us to evaluate its coding potential.

244 PIP4 binding in a cytosol-proximal membrane region triggers a 90 degrees r

245 as a general sensor of proteotoxicity in the cytosol remains unclear.

246 f a single strand of transforming DNA to the cytosol, requires the channel protein ComEC.

247 uses leakage of neutrophil elastase into the cytosol, resulting in secondary cleavage of GSDMD to an

248 The accumulation of DNA in the cytosol serves as a key immunostimulatory signal associa

249 aequorin-based Ca(2+) probes targeted to the cytosol, subplasma membrane domain, or the mitochondrial

250 are much suppressed compared to those in the cytosol, suggesting that these kinases are regulated dif

251 or protein at cell-cell junctions and in the cytosol, supporting normal blood vessel integrity and de

252 olonged impact of the oxidative burst in the cytosol that is modified in redox mutants.

253 tly secreted, MMPs have been detected in the cytosol, the mitochondria or the nucleus.

254 Neglecting efflux of H2O2 to the cytosol, the mitochondrial reaction network is expected

255 ncoded protein of interest translated in the cytosol, the self-reassembly of this Bi-Genomic-encoded

256 ilitates escape of SV40 from the ER into the cytosol, thereby providing a path for the virus to enter

257 n of the parasite's digestive vacuole to the cytosol, thereby providing a source of amino acids for p

258 changer (I(NCX))-mediated Ca(2+) efflux from cytosol, thereby reducing EADs.

259 releases mitochondrial DNA (mtDNA) into the cytosol, thereby triggering the type Iota interferon (IF

260 bstrates could be released from CPS into the cytosol through desthiobiotin-biotin exchange.

261 Extracellular CDNs can enter the cytosol through several pathways but how CDNs work from

262 al pore, which is connected laterally to the cytosol through the cavity within each protomer.

263 leased from endosomes and lysosomes into the cytosol through TRPML1 channels is vital for trafficking

264 ut protein folding status to the nucleus and cytosol to adjust the protein folding capacity of the ce

265 ional antibodies (anti-NPC and anti-pAkt) to cytosol to elicit their bioactivity towards binding intr

266 these sealed replication compartments to the cytosol to ensure their translation and the assembly of

267 ical inflammasome by directly binding in the cytosol to human caspase-4 and mouse caspase-11.

268 e requires ARF GEFs to be recruited from the cytosol to intracellular membrane compartments.

269 inhibitor superfamily-translocates from the cytosol to mitochondria and binds to cardiolipin in the

270 rations in trafficking of iron directly from cytosol to mitochondria.

271 NOD-like receptors (NLRs) localize in the cytosol to recognize intracellular pathogen products and

272 justing the rate of pyruvate supply from the cytosol to the mitochondria.

273 ma, and CREB2, translocate from dendrites or cytosol to the nucleus upon synaptic activity, suggestin

274 at Gag proteins trafficked directly from the cytosol to the plasma membrane, we discovered that the o

275 stranded RNA (dsRNA), RIG-I and MDA5 undergo cytosol-to-membrane relocalization to bind and signal th

276 osolic complex that also mediates SV40 ER-to-cytosol transport.

277 viruses, which successfully escape into the cytosol, trigger a second system of inflammasome activat

278 ells and tissues, specifically targeting the cytosol, vacuole, plasma membrane, and wall of plant cel

279 clei, showing that the physical state of the cytosol varies spatially within a single cell.

280 Thus, the physical properties of the cytosol vary substantially in time and space and can be

281 n 75 (ISG75), followed by transport into the cytosol via a lysosomal transporter.

282 efflux of H2O2 from the mitochondria to the cytosol was evidenced by peroxiredoxin-2 (Prx2) oxidatio

283 Conjugation in the cytosol was more efficient when SpyCatcher was displayed

284 n-induced degradation of IkappaBalpha in the cytosol was not affected in ATG7-depleted cells, suggest

285 d the O Ag or failed to replicate within the cytosol were incapable of blocking apoptosis and exhibit

286 (LbNOX)(13) targeted to the mitochondria or cytosol were still unable to grow tumours.

287 ma gondii lives inside a vacuole in the host cytosol where it is protected from host cytoplasmic inna

288 the ER membrane called "focus" to reach the cytosol, where it disassembles before nuclear entry to p

289 nd leads to the accumulation of DELE1 in the cytosol, where it interacts with HRI and activates the e

290 llows escape of phagosomal contents into the cytosol, where they access the endogenous major histocom

291 e protein dislocation machinery to reach the cytosol, where they exert their cytotoxic effects.

292 Cs the majority of bacilli were found in the cytosol, where they promoted rapid lipid synthesis, hidi

293 13A2 pumps polyamines like spermine into the cytosol, whereas ATP13A2 dysfunction causes lysosomal po

294 RFA1 is localized both in the nucleus and cytosol, whereas RFA4 shows specific nuclear localizatio

295 preponderance of chromatin fragments in the cytosol, which leads to a premature senescence phenotype

296 ing escape of the virus from the ER into the cytosol, which leads to infection.

297 passing between the transmembrane cavity and cytosol, which must be accommodated.

298 a's ability to release cytochrome c into the cytosol, which triggers the apoptotic cascade.

299 um tuberculosis TPP production starts in the cytosol with the formation of a diacyltrehalose intermed

300 ion of Pg within single-membrane vacuoles or cytosol, with some nuclear localization apparent.