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1 ctivated by protein kinase C lambda/iota and cytosolic phospholipase A2.
2 P kinases and induces the phosphorylation of cytosolic phospholipase A2.
3 rifluoromethyl ketone, a potent inhibitor of cytosolic phospholipase A2.
4 al probes, such as lysosomal acid lipase and cytosolic phospholipase A2.
5 FP, but by inhibitors of either secretory or cytosolic phospholipase A2.
7 cells, PDGF-induced MAPK activation leads to cytosolic phospholipase A2 activation, PGE2 release, and
9 included measurement of prostaglandin E2 and cytosolic phospholipase A2 activity in membrane fraction
12 ee functionally distinct signaling proteins: cytosolic phospholipase A2-alpha (cPLA2-alpha), protein
13 as novel therapeutic targets in cancer (eg, cytosolic phospholipase A2, an upstream target of the cy
14 ression of key enzymes in NPD1 biosynthesis, cytosolic phospholipase A2 and 15-lipoxygenase, was alte
15 Similarly, PGF2alpha causes translocation of cytosolic phospholipase A2 and also results in a 7-fold
16 Enhancement was blocked by inhibitors of cytosolic phospholipase A2 and cytochrome P450 epoxygena
17 arachidonic acid from phospholipid stores by cytosolic phospholipase A2 and cytochrome P450 metabolis
18 which is due to a constitutively stimulated cytosolic phospholipase A2 and enhanced basal expression
19 osphorylation and activation of the Group IV cytosolic phospholipase A2 and of the extracellular-sign
20 ll as beta-arrestin1-dependent activation of cytosolic phospholipase A2 and release of arachidonate,
21 age-dependent alpha1G subtype Ca2+ channels, cytosolic phospholipase A2, and epoxyeicosatrienoic acid
22 ETE from membrane phospholipids by group IVA cytosolic phospholipase A2, and its conversion to bioact
23 l proliferation; to induce the activation of cytosolic phospholipase A2; and to inhibit Na+-K+-ATPase
24 ar relevance to studies on the regulation of cytosolic phospholipase A2 as these two MAPKs are capabl
25 d the binding of beta-arrestin1 to activated cytosolic phospholipase A2 as well as beta-arrestin1-dep
26 phosphorylation of Raf1, MEK1, p42mapk, and cytosolic phospholipase A2, as well as the associated in
27 es upon cell stimulation, and cooperate with cytosolic phospholipase A2 at the membrane surface to ge
30 ether the RvD1 biosynthetic machinery (e.g., cytosolic phospholipase A2, calcium-independent phosphol
31 utamate signaling through the NMDA receptor, cytosolic phospholipase A2, COX-2, and mPGES-1 increases
32 re stretched, the peripheral membrane enzyme cytosolic phospholipase A2 (cPLA(2)) binds via its calci
34 F. tularensis-infected macrophages requires cytosolic phospholipase A2 (cPLA(2)), cyclooxygenase 2 (
35 a novel, activation state-dependent role for cytosolic phospholipase-A2 (cPLA(2)) in myelin-mediated
36 ive of this study was to investigate whether cytosolic phospholipase A2 (cPLA2 ), an important isofor
37 high levels of MYC, we found an increase in cytosolic phospholipase A2 (cPLA2) activity with a prefe
38 on specifically inhibited receptor-dependent cytosolic phospholipase A2 (cPLA2) activity, whereas thi
39 on in VWF/GPIb-IX-induced phosphorylation of cytosolic phospholipase A2 (cPLA2) and consequent thromb
40 cells have constitutively high expression of cytosolic phospholipase A2 (cPLA2) and cyclooxygenase (C
41 by constitutively high expression of 85-kDa cytosolic phospholipase A2 (cPLA2) and cyclooxygenase 2
43 ing findings exist regarding the function of cytosolic phospholipase A2 (cPLA2) and its role in membr
44 rapidly activates the enzymatic activity of cytosolic phospholipase A2 (cPLA2) as at-tested to by ar
45 NE enhanced release of AA via activation of cytosolic phospholipase A2 (cPLA2) but not secretory PLA
54 ase-1 (COX-1), cyclooxygenase-2 (COX-2), and cytosolic phospholipase A2 (cPLA2) expression, the rate-
59 port we examine the phosphorylation state of cytosolic phospholipase A2 (cPLA2) in C3HA fibroblasts t
60 be due to the relatively lower expression of cytosolic phospholipase A2 (cPLA2) in H596 cells than th
61 fies the phosphorylation sites of the 85-kDa cytosolic phospholipase A2 (cPLA2) in human platelets an
62 mediating phosphorylation and activation of cytosolic phospholipase A2 (cPLA2) in intact cells remai
63 rol expression of the arachidonyl-selective, cytosolic phospholipase A2 (cPLA2) in intestinal cells.
68 dependent lipid binding domain of the 85-kDa cytosolic phospholipase A2 (cPLA2) is a homolog of C2 do
71 have reported recently that the activity of cytosolic phospholipase A2 (cPLA2) is necessary for the
74 erest to know whether arachidonate-releasing cytosolic phospholipase A2 (cPLA2) localizes at lipid bo
76 yotic signal-transducing proteins, including cytosolic phospholipase A2 (cPLA2) of the vertebrate inf
78 GF, but not IGF-I, stimulated MAPK activity, cytosolic phospholipase A2 (cPLA2) phosphorylation, and
80 ticularly the potential contributions of the cytosolic phospholipase A2 (cPLA2) signaling pathway.
83 AA) release and on protein levels of p11 and cytosolic phospholipase A2 (cPLA2) was studied in two ep
84 thway (Ras/Raf/MEK/ERK) and Ca(2+)-dependent cytosolic phospholipase A2 (cPLA2) were activated in chl
85 e phosphorylation sites on the human, 85-kDa cytosolic phospholipase A2 (cPLA2) were identified using
86 triggers the interaction of the C2 domain in cytosolic phospholipase A2 (cPLA2) with the CARD domain
87 e gel electrophoresis immunoblot signals for cytosolic phospholipase A2 (cPLA2), 5-lipoxygenase (5-LO
89 e, both basal and IL-1-induced expression of cytosolic phospholipase A2 (cPLA2), a key enzyme-regulat
90 on increased phosphorylation and activity of cytosolic phospholipase A2 (cPLA2), an enzyme causing AA
91 g (1) inhibition of nuclear translocation of cytosolic phospholipase A2 (cPLA2), and (2) blockade of
92 rylation of ERKs, whereas phosphorylation of cytosolic phospholipase A2 (cPLA2), and arachidonic acid
93 (Ad5) affects the expression and activity of cytosolic phospholipase A2 (cPLA2), cyclooxygenase-2 (CO
95 glutamate released during seizures activates cytosolic phospholipase A2 (cPLA2), resulting in P-gp an
96 mitogen-activated protein kinase (MAPK) and cytosolic phospholipase A2 (cPLA2), resulting in release
97 quires protease-activated receptors 1 and 4, cytosolic phospholipase A2 (cPLA2), Src tyrosine kinases
98 ism of calcium-dependent membrane binding of cytosolic phospholipase A2 (cPLA2), we measured the inte
99 ed protein (MAP) kinase in the regulation of cytosolic phospholipase A2 (cPLA2)-mediated AA release b
110 rachidonic acid by phospholipase A2, and the cytosolic phospholipase A2 (cPLA2)alpha isoform has been
111 ular dynamics simulation of the C2 domain of cytosolic phospholipase A2 (cPLA2-C2) in a 1-palmitoyl-2
112 amino-terminal, 138 amino acid C2 domain of cytosolic phospholipase A2 (cPLA2-C2) mediates an initia
113 pholipase A2 (sPLA2) amplifies the action of cytosolic phospholipase A2(cPLA2) alpha in regulating ei
116 sion was shown to require activation of host cytosolic phospholipase A2 (cPLA2alpha) by Loops1 and 2
117 There is compelling evidence that group IVA cytosolic phospholipase A2 (cPLA2alpha) targets arachido
120 itoneal macrophages, activation of group IVA cytosolic phospholipase A2(cPLA2alpha) by calcium- and m
121 ptotagmin I (SytIC2A) and the C2 domain from cytosolic phospholipase A2 (cPLA2C2) are among the best
123 staglandin E2 (PGE2) via a calcium-dependent cytosolic phospholipase A2/cyclooxygenase-mediated mecha
124 iglyceride and free fatty acid content and a cytosolic phospholipase A2-dependent increase in formati
125 tracellular Ca2+ concentration and activates cytosolic phospholipase A2, followed by lipoxygenase-cat
131 ed that an A-->G variant (rs12746200) of the cytosolic phospholipase A2 group IVA gene (PLA2G4A), whi
132 xercised in using AACOCF3 as an inhibitor of cytosolic phospholipase A2 in whole cell assays because
133 Pretreatment of DARas with antioxidants or a cytosolic phospholipase A2 inhibitor also restores the w
136 determine the effects of a putative specific cytosolic phospholipase A2 inhibitor, arachidonyl triflu
142 g down keratin disulfide bonds, it activated cytosolic phospholipase A2, leading to activation of the
143 g down keratin disulfide bonds, it activated cytosolic phospholipase A2, leading to activation of the
144 ion of this Ras-MAP kinase pathway activated cytosolic phospholipase A2, leading to the release of ar
145 cells that express tau, receptors coupled to cytosolic phospholipase A2 may activate PLC-gamma isozym
147 arthritis correlated with altered COX-2 and cytosolic phospholipase A2 messenger RNA levels in the j
150 ntly, E-FABP deletion by CRISPR-Cas9 reduced cytosolic phospholipase A2/peroxisome proliferator-activ
151 ntly, E-FABP deletion by CRISPR-Cas9 reduced cytosolic phospholipase A2/peroxisome proliferator-activ
152 ed extracellular signal-regulated kinase and cytosolic phospholipase A2 phosphorylation, consistent w
154 achidonic acid by the ubiquitously expressed cytosolic phospholipase A2 (PLA2) has a fundamental role
155 function we demonstrated increased levels of cytosolic phospholipase A2 protein and related lipid med
156 the Ca2+-dependent lipid-binding domains of cytosolic phospholipase A2, protein kinase C, Rabphilin-
157 utocrine loop by which LPI is synthesized by cytosolic phospholipase A2, pumped out of the cell by th
159 activation were observed, whereas ERK1/2 and cytosolic phospholipase A2 (S505) phosphorylation was no
161 ein's ability to induce prostaglandin E2 and cytosolic phospholipase A2 synthesis in patients' fibrob
162 noid synthesis proximal to the activation of cytosolic phospholipase A2, the initial rate-limiting st
163 ese two MAPKs are capable of phosphorylating cytosolic phospholipase A2, thereby increasing its intri
165 decrease in expression of MEK1, p42mapk, and cytosolic phospholipase A2, which may contribute further
166 (2+)- and kinase-dependent activation of the cytosolic phospholipase A2, which releases arachidonic a
167 ssion of cyclooxygenase-2 and phosphorylated cytosolic phospholipase A2, which was reflected in prost