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1 somehow escape endocytic vesicles to contact cytosolic protein.
2 nding interactions with a folded or unfolded cytosolic protein.
3 emonstrated a dose-dependent increase in Ras cytosolic protein.
4 ing frame of unknown function that encodes a cytosolic protein.
5 n compared with the wild-type or exclusively cytosolic protein.
6 protein fractions compared with cell wall or cytosolic proteins.
7 brane proteins or diffusional entry of small cytosolic proteins.
8 belong to a small family of multifunctional cytosolic proteins.
9 alues close to the isoelectric point of many cytosolic proteins.
10 TRAP_Cy3) to trap and visualize dithiols in cytosolic proteins.
11 causes the loss of solubility intracellular cytosolic proteins.
12 s may result from more widespread effects on cytosolic proteins.
13 down IRF5 from a mixture of endothelial cell cytosolic proteins.
14 lucosamine (O-GlcNAc) to various nuclear and cytosolic proteins.
15 the less hydrophobic amino acid segments in cytosolic proteins.
16 domains that distinguish MLPs from potential cytosolic proteins.
17 re was little impact on Ag presentation from cytosolic proteins.
18 a more restricted role in the processing of cytosolic proteins.
19 lational modification of diverse nuclear and cytosolic proteins.
20 interaction and docking targets for various cytosolic proteins.
21 ity of the cytosolic domain to interact with cytosolic proteins.
22 of protein methylation in the regulation of cytosolic proteins.
23 ell might also be facilitated by target cell cytosolic proteins.
24 ctive lysosomal mechanism for degradation of cytosolic proteins.
25 partments for the sequestration of misfolded cytosolic proteins.
26 es, which may recognize membrane, nuclear or cytosolic proteins.
27 rimentally dissect cell surface-exposed from cytosolic proteins.
28 o efficient in preventing the aggregation of cytosolic proteins.
29 le in unconventional secretion of leaderless cytosolic proteins.
31 OR], 2.54; P = 1.20 x 10(-6)) and lymphocyte cytosolic protein-1 (LCP1) (OR, 3.29; P = 2.96 x 10(-6))
32 m, MG formation and glycation and changes in cytosolic protein abundances, MG modification and proteo
34 tical for the capture of heat stress-induced cytosolic protein aggregates and their retention in the
37 we show that HRI controls autophagy to clear cytosolic protein aggregates when the ubiquitin-proteaso
39 eed by coupling an active transport model of cytosolic proteins along a two-dimensional microtubule (
41 atially distinguishable transport routes for cytosolic proteins: an IFT-dependent path along the axon
43 D66 encodes an approximately 30-kDa soluble, cytosolic protein and that the chymotrypsin-like activit
44 ded with the impaired turnover of long-lived cytosolic proteins and accumulation of autophagosomes.
46 tions manifest themselves via scaffolding of cytosolic proteins and cytoskeletal networks to specific
47 ophagy (autophagy) is a process wherein bulk cytosolic proteins and damaged organelles are sequestere
48 ification is present on numerous nuclear and cytosolic proteins and has been implicated in essential
49 ophagy controls the degradation of selective cytosolic proteins and may protect neurons against degen
50 tabolic process, leads to the degradation of cytosolic proteins and organelles in the vacuole/lysosom
51 otes that utilizes small vesicles to traffic cytosolic proteins and organelles to the vacuole for bre
55 ise to nuclear chromosomal genes that encode cytosolic proteins and precursor proteins that are synth
56 e system by binding to peptides derived from cytosolic proteins and presenting them on the cell surfa
57 h altered ubiquitin-dependent degradation of cytosolic proteins and regulation of protein synthesis d
58 Entry into the microdomain is selective for cytosolic proteins and requires a binding pathway to Pop
59 densed chromatin decorated with granular and cytosolic proteins and they can trap extracellular patho
60 n be sensed by a growing number of host cell cytosolic proteins and TLR3, which contribute to the ind
61 lling, (vi) degradation of Mo and fibroblast cytosolic proteins, and (vii) promotion of survival of i
67 e role of macroautophagy, a process in which cytosolic proteins are delivered to the lysosome by de n
70 ittle is currently known about how misfolded cytosolic proteins are recognized by protein quality con
72 elective type of autophagy by which specific cytosolic proteins are sent to lysosomes for degradation
77 Our observations establish misfolding of cytosolic proteins as an effect of aminoglycoside action
80 directly interacts with several membrane and cytosolic proteins at neuronal plasma membranes, leading
81 mics, electrical signaling, and diffusion of cytosolic proteins at unprecedented spatial resolution.
87 ation of NUP62 attenuated the gated entry of cytosolic proteins but did not affect entry of membrane
88 osttranslational modification of nuclear and cytosolic proteins but is present also in mitochondria.
91 osttranslational modification of nuclear and cytosolic proteins by O-linked beta-N-acetylglucosamine
92 chanism whereby overexpression of a specific cytosolic protein bypasses the essentiality of an inner
94 first demonstration that large fragments of cytosolic proteins can be accumulated in prematurely sen
99 n induces pyroptosis, which is mediated by a cytosolic protein complex called the inflammasome that s
101 LRP3) inflammasome is a caspase-1-containing cytosolic protein complex that is essential for processi
103 uries trigger the assembly of inflammasomes, cytosolic protein complexes that activate caspase-1, lea
104 strictly controlled by several lysosomal or cytosolic protein complexes that directly detect and tra
115 a strategy for analyzing axonal transport of cytosolic proteins (CPs) using photoactivatable GFP-PAGF
118 easome inhibition enhanced activation of the cytosolic protein damage sensor HSF1, elevated levels of
119 ydomonas reinhardtii, we discovered that the cytosolic protein degradation machinery is concentrated
120 that distinct autophagic mechanisms control cytosolic protein delivery to late endosomes and identif
121 cytosol (yHsp60c) inhibits degradation of a cytosolic protein DeltaMTS-Aco1 tagged with the degron S
122 -10) cm(2) s(-1)) but increased with time as cytosolic protein density, which was initially high, dec
125 ave indicated that mammalian cells contain a cytosolic protein disaggregation machinery comprised of
128 sociated with alpha-synuclein (alpha-syn), a cytosolic protein enriched in presynaptic terminals.
129 is work, we investigated the function of the cytosolic protein EspG(5), which is essential for ESX-5-
130 Bassoon and Piccolo are active zone specific cytosolic proteins essential for active zone assembly in
131 ultisite membrane-anchored proteins, but not cytosolic proteins, even when enzymes are in excess.
132 tes, about one-third of the Escherichia coli cytosolic proteins exhibit cotranslational folding, with
134 rt system requires three proteins: the small cytosolic proteins FeoA and FeoC and a large cytoplasmic
136 termine whether there is evidence of altered cytosolic protein folding by assessing whether amyloid d
137 fy new mechanisms for selection of misfolded cytosolic proteins for degradation via defining function
138 ng a genetic screen, we identified two novel cytosolic proteins, Fra1 and Fra2, that are part of a co
141 that zGrad can inactivate transmembrane and cytosolic proteins globally, locally and temporally with
144 et nuclear proteins and, to a lesser extent, cytosolic proteins, hardly anything is known about the S
145 tants to establish that the levels of ZTL, a cytosolic protein, help govern the abundance and distrib
148 tes by Nogo-A exposure, identifying CRMP2, a cytosolic protein implicated in axon growth inhibition b
149 ith a short cytoplasmic domain can recruit a cytosolic protein in a phospholipid and Ca(2+)-specific
150 loid-related protein 14 (MRP14), an abundant cytosolic protein in myeloid cells, acts as an endogenou
151 our application of STICS to freely diffusing cytosolic protein in small cells extends the utility of
155 a selective mechanism for the degradation of cytosolic proteins in lysosomes that contributes to cell
156 gy (CMA), a selective form of degradation of cytosolic proteins in lysosomes, contributes to maintena
157 A), a selective mechanism for degradation of cytosolic proteins in lysosomes, contributes to the remo
162 al locations of transport routes for various cytosolic proteins in the 250-nm-wide shaft of live prim
163 the external medium requires the addition of cytosolic proteins including coatomer protein complex I
165 selected peptide-bound glutamine residues of cytosolic proteins (including actin and tubulin), while
166 d by a variety of receptor interactions with cytosolic proteins, including those that may be previous
167 osis inhibitory molecule (FAIM) is a soluble cytosolic protein inhibitor of programmed cell death and
168 Ric-8A) is a highly evolutionarily conserved cytosolic protein initially identified in Caenorhabditis
169 ively implicate the luminal location of host cytosolic proteins inside secreted exosomes, we provide
170 propose a model in which active transport of cytosolic proteins into both nuclear and ciliary compart
171 el where Hsc70 activity dynamically clusters cytosolic proteins into cargo complexes, allowing transp
173 t leads to enhanced turnover of non-critical cytosolic proteins into sources of energy or clearance o
174 ays for proteasomal degradation of misfolded cytosolic proteins involve functional interplay between
176 alpha-Synuclein (alpha-Syn) is an abundant cytosolic protein involved in the release of neurotransm
177 or proteins 5 (CRMP5) belongs to a family of cytosolic proteins involved in axon guidance and neurite
178 m the ER membrane not only YOD1 and p97, two cytosolic proteins involved in the extraction of ER tran
180 nd its "constitutive" interactions with some cytosolic proteins, it nevertheless is a prerequisite bo
181 Nrf2 activity is controlled, in part, by the cytosolic protein Keap1, but the nature of this pathway
184 Dimeric tubulin, an abundant water-soluble cytosolic protein known primarily for its role in the cy
186 Unlike classical calpains, CAPN5 is a non-cytosolic protein localized to the nucleus and extra-nuc
187 implicate the periplasmic protein LptA, the cytosolic protein LptB, and the IM proteins LptC, LptF,
188 Here, we show that aminoglycosides cause cytosolic protein misfolding and that chaperonin GroEL/G
190 Liver fatty acid binding protein (L-FABP), a cytosolic protein most abundant in liver, is associated
191 r (vasopressin type 2 receptor; V(2)R) and a cytosolic protein (Na(+)/H(+) exchanger regulatory facto
192 serine and threonine residues of nuclear and cytosolic proteins (O-GlcNAc) is a posttranslational mod
196 neral homeostatic process for degradation of cytosolic proteins or organelles, has been reported to m
198 to the accumulation of damaged or aggregated cytosolic proteins, or membranes, and rely on autophagy
203 ntify SBP-AR and associated ligand-sensitive cytosolic proteins/protein complexes linked to AR activa
204 nappreciated regulatory pathway coordinating cytosolic protein quality control and mTORC1 signaling.
205 eover, mitochondrial proteostasis depends on cytosolic protein quality control mechanisms during cris
206 In conclusion, our results suggest that a cytosolic protein quality control pathway monitors foldi
207 e that ubiquitin chain editing is key to the cytosolic protein quality control under stress condition
208 his protein family, ZFP36L3 is a "full-time" cytosolic protein, rather than a nucleocytoplasmic shutt
209 no spurious signal even with highly abundant cytosolic proteins readily accessible to the bud neck (i
215 Myeloid-related proteins (MRPs) 8 and 14 are cytosolic proteins secreted from myeloid cells as proinf
217 n of these degradative compartments requires cytosolic proteins, some of which are autophagy specific
219 intracellular inclusion pathology formed by cytosolic proteins such as Tau, alpha-synuclein and TDP-
221 ajority of the identified proteins were host cytosolic proteins, suggesting that S. aureus was rapidl
222 osterically through binding to a site on the cytosolic protein surface, which is different from the e
224 Stromule induction by ABA was dependent on cytosolic protein synthesis, but not plastid protein syn
225 of nascent chain length for Escherichia coli cytosolic proteins synthesized on both arrested and cont
226 found that in cultured axons, populations of cytosolic proteins tagged to photoactivatable GFP (PAGFP
228 lexin, also known as synaphin, is a neuronal cytosolic protein that acts as a major regulator of syna
232 quitinated proteins and that it is a soluble cytosolic protein that can be induced by interferons and
234 sicle-trafficking proteins, and for DHAR1, a cytosolic protein that facilitates the scavenging of rea
235 FL1 appears to be an example of a eukaryotic cytosolic protein that has been coopted for a function i
236 ors of Cholinesterase A (Ric-8A) is a 60-kDa cytosolic protein that has chaperone and guanine nucleot
237 y acid-binding protein (L-Fabp), an abundant cytosolic protein that modulates fatty acid (FA) metabol
238 RH domain-interacting protein (SHARPIN) is a cytosolic protein that plays a key role in activation of
239 clear prelamin A recognition factor-like), a cytosolic protein that plays a role in the cytosolic iro
240 Rhesus TRIM5alpha (TRIM5alpha(rh)) is a cytosolic protein that potently restricts HIV-1 at an ea
243 t, an integral membrane protein but rather a cytosolic protein that tightly associates with cellular
244 OXO1beta [NOXO1 (Nox organizer 1) beta] is a cytosolic protein that, in conjunction with NOXA1 (Nox a
245 on chromatography, we identified hundreds of cytosolic proteins that appeared to exist as components
246 exins, found in most eukaryotic species, are cytosolic proteins that are able to bind negatively-char
247 embrane proteins, cytoskeletal proteins, and cytosolic proteins that are strongly associated with the
250 somes containing kidney-derived membrane and cytosolic proteins that can be used to probe the proteom
251 he interleukin-1 (IL-1) family cytokines are cytosolic proteins that exhibit inflammatory activity up
252 of 30 yeast strains with single deletions of cytosolic proteins that have known or hypothesized chape
253 liary subunits KCTD8, -12, -12b, and -16 are cytosolic proteins that influence agonist potency and G-
254 UBX-containing protein, UBXD4, as one of the cytosolic proteins that interact directly with the alpha
255 the basis for NO inhibition and to identify cytosolic proteins that may be involved, using inducible
257 rotein 5 (CRMP5) belongs to a family of five cytosolic proteins that play a major role in nervous sys
259 proteomic approaches, we identified numerous cytosolic proteins that show specific losses in solubili
261 7) are an evolutionarily conserved family of cytosolic proteins that transiently assembles into helic
265 Orai with the carboxy terminus of Stim as a cytosolic protein to activate the Orai channel without i
266 e demonstrate light-induced recruitment of a cytosolic protein to individual centromeres, kinetochore
268 ed specific ribosomal and bulk ubiquitinated cytosolic proteins to autolysosomes where they were prot
269 , our results suggest that routing misfolded cytosolic proteins to ER may be an effective strategy fo
270 agy (CMA), a process that delivers selective cytosolic proteins to lysosomes for degradation, with pr
271 -mediated autophagy involved in transport of cytosolic proteins to the lysosome for degradation.
272 To address this issue, we have targeted cytosolic proteins to the mitochondrion, a poly(A) speci
273 autophagy-like process that delivers soluble cytosolic proteins to the vesicles of late endosomes/mul
274 idic clusters, which interact with PACS-1, a cytosolic protein, to mediate retrograde transport from
275 r bound of about 7 to 16% on the fraction of cytosolic protein translation carried out by ribosomes a
277 Candidates included cytoskeletal regulators, cytosolic protein transporters, exocytosis and endocytos
278 axonal transport via motor-driven vesicles, cytosolic proteins travel in slow axonal transport via m
279 ane adapter protein PAG1, which recruits the cytosolic protein tyrosine kinase Csk to the plasma memb
280 inducible F(V)2E dimerization domain and the cytosolic protein tyrosine kinase domain of the insulin
281 ollows: BCR, Lyn, Fyn, Csk, PAG1, and Syk, a cytosolic protein tyrosine kinase that is activated as a
282 gle DHCH1 and FTL genes encoding exclusively cytosolic proteins, unlike other organisms where isoform
284 regulation involves assembly of an ISC on a cytosolic protein using Fecyt and a sulfur species gener
286 c) availability, and lead to modification of cytosolic proteins via O-linked attachment of the monosa
289 urred during evolution, whenever ancestrally cytosolic proteins were recruited to the secretory pathw
292 l TDP-43 increased the levels of nuclear and cytosolic protein, whereas Parkin co-expression mediated
293 ding to tyrosine-phosphorylated receptors or cytosolic proteins, which leads to the formation of larg
294 ha- and gamma-adaptin-binding protein p34, a cytosolic protein with a Rab-like GTPase domain, was sho
299 with only protein disulfide isomerase or all cytosolic proteins with only PA700, the 19S regulatory p