ライフサイエンスコーパス: cytosolic tail

1 -like domains, a transmembrane domain, and a cytosolic tail.

2 omain and the adjacent 28 amino acids of the cytosolic tail.

3 putative polarized targeting signals in the cytosolic tail.

4 ts were isolated using antibodies to the CPD cytosolic tail.

5 tion are independent of the Kex2p C-terminal cytosolic tail.

6 ot deletions of the TLS or entire C-terminal cytosolic tail.

7 ization signal (TLS) in the Kex2p C-terminal cytosolic tail.

8 ated with the carboxyl terminus of the beta3 cytosolic tail.

9 omain containing the fifth TMH (TMH-V) and a cytosolic tail.

10 res the dysferlin (DysF) domain on the Pex30 cytosolic tail.

11 nteraction screen for interactors of the APP cytosolic tail.

12 tly interacts with a YENPTY motif in the APP cytosolic tail.

13 plasmalemma domains and deletion of PECAM-1 cytosolic tail.

14 eolyzed form of Drs2p lacking the C-terminal cytosolic tail.

15 l fragment containing the channel domain and cytosolic tail.

16 ine located in a YxxL sequence in the CLEC-2 cytosolic tail.

17 nserved hydrophobic domain in the C-terminal cytosolic tail.

18 ptor tyrosine-based inhibitory motifs in its cytosolic tail.

19 tyrosine Lck kinase binding site in the CD28 cytosolic tail.

20 the removal of the transmembrane domain and cytosolic tail.

21 -inducible T cell kinase binding to the CD28 cytosolic tail.

22 twork (TGN) localization signal in the Kex2p cytosolic tail.

23 e substrate using antibody against the Kex2p cytosolic tail.

24 S1S3 lacking both transmembrane domains and cytosolic tails.

25 ternary complex in which CaM links two NHE1 cytosolic tails.

26 res PIP2 binding to and rearrangement of the cytosolic tails.

27 e of tyrosine-based sorting signals in their cytosolic tails.

28 an ART sorting signal in the Mup1 N-terminal cytosolic tail: 1) an extended acidic patch, 2) in close

29 hrough the TSYT(346-349) region of the CXCR1 cytosolic tail, a region divergent from the CXCR2 cytoso

30 To explore the role of the TEM8 cytosolic tail, a series of truncated TEM8 mutants was t

31 resented that caspase cleavage of APP at its cytosolic tail affects its processing such that it is re

32 de evidence that Alg14 contains a C-terminal cytosolic tail and an N terminus that resides within the

33 in the absence of interactions between CD1d cytosolic tail and the actin cytoskeleton and correlates

34 n between a PPAY motif within its C-terminal cytosolic tail and the WW domains of Rsp5p.

35 d catenins, binds directly to the E-cadherin cytosolic tail and thereby localizes at cell-cell adhesi

36 individually and simultaneously altering the cytosolic tail and transmembrane region of the STcys iso

37 via mechanisms independently mediated by its cytosolic tail and transmembrane region.

38 -like domains, a transmembrane domain, and a cytosolic tail and which functions in the processing of

39 n Siglec-10 in its extracellular domain, the cytosolic tail appears only distantly related.

40 table, while proteins lacking the N-terminal cytosolic tail are stable and multimerize efficiently, b

41 sis defined the COOH-terminal residue of the cytosolic tail as critical in governing the distribution

42 lving p56(lck) and its binding motif on CD28 cytosolic tail, as well as the lipid rafts.

43 tein tyrosine kinase Lck binding to the CD28 cytosolic tail, because point mutations in C-terminal pr

44 Sst2 docks to the Ste2 cytosolic tail, but only its unphosphorylated state, all

45 compartments is regulated by signals in the cytosolic tail, but the exact pathway is controversial.

46 A Kex2p chimera containing the cytosolic tail (C-tail) of the vacuolar protein sorting

47 e to the TGN requires a signal (TLS1) in its cytosolic tail (C-tail).

48 ly to acidic dileucine sorting motifs in the cytosolic tails (C-tails) of intracellular receptors.

49 .1/ezrin/radixin/moesin) domain to the beta3 cytosolic tail causes activation of the integrin alphaII

50 rthermore, simulations of the ARM/E-cadherin cytosolic tail complex emulating the most probable stres

51 ressing an inducible polycystin-1 C-terminal cytosolic tail construct were shown to exhibit a cAMP gr

52 racellular immunoglobulin-like domains and a cytosolic tail containing two tyrosines, one within a ty

53 ; and 3) a type I transmembrane domain whose cytosolic tail controls protease trafficking and signali

54 membrane (TM) protein with a 97-residue-long cytosolic tail (CT).

55 In mammals, GnRHR lacks a C-terminal cytosolic tail (Ctail) and does not exhibit homologous d

56 in mice bearing a transgene encoding a RAGE cytosolic tail-deletion mutant, specifically in smooth m

57 became a pseudogene) and a transmembrane and cytosolic tail derived from another ancestral Siglec.

58 n (VSD) activation and Ca(2+) binding to the cytosolic tail domain (CTD) open the pore across the mem

59 mpassing the N terminus to S6 with the mslo3 cytosolic tail domain (CTD).

60 affinity Ca(2+)-sensing sites located in the cytosolic tail domain, which underscores that Ca(2+) and

61 eptors in which the 40-amino acid C-terminal cytosolic tail domains were swapped and site mutants of

62 of the MT1-MMP hemopexin, transmembrane, and cytosolic tail domains.

63 transmembrane domain, and 40 residues of the cytosolic tail (E3-M7-24-T40) was biosynthesized fused t

64 ncation of the C-terminal 56 residues of the cytosolic tail eliminates the enrichment in the TGN and

65 We conclude that the beta8 cytosolic tail in mesangial cells organizes a signaling

66 thway to the vacuole is contained within its cytosolic tail, in the 13 residues adjacent to the trans

67 ZnT3 cytosolic tail interacted selectively with AP-3 in cell-

68 Its cytosolic tail is a disordered neutrally charged polyamp

69 rallel coiled coil conformation, whereas its cytosolic tail is flexible and exposed to the cytosol.

70 A Ctr1 mutant lacking the entire C-terminal cytosolic tail is functional in high affinity copper upt

71 tion, a variant Ctr1p with a deletion in the cytosolic tail is not internalized upon exposure of cell

72 ine overexpressing a wild-type ERGIC-53 or a cytosolic tail mutant of ERGIC-53 (KKAA) that is unable

73 tes of this proteolytic pathway bound to the cytosolic tail of a 96-kilodalton lysosomal membrane pro

74 Mutation of phenylalanine residues in the cytosolic tail of Arn1p also lead to missorting, but wit

75 is necessary for forming a complex with the cytosolic tail of BACE1 in co-immunoprecipitation assays

76 interact with specific signals found in the cytosolic tail of cargo proteins to incorporate them int

77 immunological synapse, as truncation of the cytosolic tail of CD28 disrupts synapse localization wit

78 mutation of the PI3K interaction site in the cytosolic tail of CD28 site disrupts the ability of CD28

79 to membranes as bound to Nef, such that the cytosolic tail of CD4 is situated to interact with its b

80 at Nef induces downregulation by linking the cytosolic tail of CD4 to components of the host-cell pro

81 Nef is believed to act by linking the cytosolic tail of CD4 to the endocytic machinery, thereb

82 e found that multiple lysine residues in the cytosolic tail of CD86 could support ubiquitination cons

83 Surprisingly, although the cytosolic tail of class I is required for rapid mK3-medi

84 Four putative splice variants (A-D) of the cytosolic tail of densin-180 are shown to be differentia

85 spindle orientation machinery that binds the cytosolic tail of E-cadherin.

86 protein-tyrosine phosphatase that binds the cytosolic tail of Fas (Apo1, CD95), presumably regulatin

87 Mutation of an IXTPK sequence in the cytosolic tail of Fus1p abolishes its physical interacti

88 e) in lysates of infected cells and with the cytosolic tail of gD fused to glutathione S-transferase

89 Ubiquitination of the cytosolic tail of heavy chain is not required for its di

90 MHC molecule, replacement of lysines in the cytosolic tail of heavy chains with arginine does not pr

91 petition, i.e., the intrinsically disordered cytosolic tail of Integrin-alpha1 displaces the TCPTP au

92 localization signal (TLS) in the C-terminal cytosolic tail of Kex2p consisting of Tyr-713 and contex

93 This cytosolic tail of LAMP-2A interacts with chaperone Hsc70

94 -hand protein ALG-2 binds to the NH-terminal cytosolic tail of MCOLN1.

95 ese interactions can be reconstituted on the cytosolic tail of neurexins.

96 Here, we show that residues 1290-1309 in the cytosolic tail of NR2B are critical for CaMKII binding a

97 Remarkably, TCRalpha has a cytosolic tail of only five amino acid residues (i.e. RL

98 brane-proximal, polybasic motif (PBM) in the cytosolic tail of p14 is essential for efficient export

99 The cytosolic tail of PAM interacts with proteins that can a

100 a, in which the transmembrane domain and the cytosolic tail of PC7 were replaced by that of the conve

101 demonstrated previously that the C-terminal cytosolic tail of polycystin-1 binds and activates heter

102 II (Ang II) triggered transactivation of the cytosolic tail of RAGE and NF-kappaB-driven proinflammat

103 identify SLP76 as a binding partner for the cytosolic tail of RAGE both in vitro and in vivo and dem

104 reported that a polybasic motif (PBM) in the cytosolic tail of reptilian reovirus p14 FAST protein fu

105 that an amphipathic helix in the C-terminal cytosolic tail of RHD3 has a membrane anchoring ability

106 in common subcellular vesicles in which the cytosolic tail of rOATP1A1 is bound to PDZK1.

107 h the tyrosine-based inhibitory motif in the cytosolic tail of Siglec-F, the data suggested a negativ

108 tion of two conserved serine residues in the cytosolic tail of TCRalpha to alanine decreased ubiquiti

109 he interaction of an YKFFE sequence from the cytosolic tail of the Alzheimer's disease amyloid precur

110 hough ubiquitin conjugation may occur on the cytosolic tail of the class I MHC molecule, replacement

111 The data suggest that the cytosolic tail of the endothelin B receptor is involved

112 n neurons by binding to the C0 region in the cytosolic tail of the NR1 subunit.

113 s largely mediated by sorting signals in the cytosolic tail of the protein, we show here that targeti

114 We found that part of the N-terminal cytosolic tail of the V-ATPase a2-subunit (a2N), corresp

115 MIR1 and MIR2 leads to ubiquitination of the cytosolic tail of their target proteins and that ubiquit

116 The cytosolic tail of US2 and certain US2 lumenal sequences,

117 e propose that conformational changes in the cytosolic tail of yeast Ctr1 by copper sensing within th

118 The cytosolic tails of both receptors contain acidic-cluster

119 on that makes contacts with the membrane and cytosolic tails of cargo proteins.

120 hat functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during

121 To analyze this finding, the cytosolic tails of DEC-205 and MMR were fused to the ext

122 ng GOLPH3, an adaptor protein that binds the cytosolic tails of many Golgi residents.

123 ted features in tyrosine-based motif-bearing cytosolic tails of many, especially, inhibitory receptor

124 ced green fluorescent fusion proteins of the cytosolic tails of mENaC subunits were consistent with r

125 tudy, we have tested the hypothesis that the cytosolic tails of sClC3 bind to actin directly and that

126 strate that BDCPs interact directly with the cytosolic tails of selected TMPs and identify a subset o

127 well as with a binding motif present in the cytosolic tails of some mannosyltransferases.

128 The structural and dynamic properties of the cytosolic tails of the adhesion receptor integrin alphaI

129 hrough recognition of sorting signals in the cytosolic tails of the cargos by adaptor proteins, leadi

130 activation can drive a reorientation of the cytosolic tails of the CD28 dimer.

131 taTrCP, CHIP interacts specifically with the cytosolic tails of the dimeric GHR, identifying both Ubc

132 tation screen to identify regions within the cytosolic tails of the mouse alpha, beta, and gamma epit

133 osomes is mediated by signals present in the cytosolic tails of the proteins.

134 hion and to recognize sorting signals in the cytosolic tails of the transmembrane cargo.

135 g of BDCPs and clathrin coat adaptors to the cytosolic tails of TMPs, followed by their clustering to

136 nearby Ca(2+)-recognition sites in the slo1 cytosolic tail: one high-affinity and one low-affinity s

137 e sequence Yxx(L/I)x(6-12)Yxx(L/I), in their cytosolic tails or associated receptor chains.

138 As the cytosolic tail participates in down-regulation of Ste2p,

139 chimeric protein (K-V), in which the Vps10p cytosolic tail replaces the Kex2p tail.

140 ted nor were the conserved lysines in the mu cytosolic tail required for trafficking to late endosome

141 Nevertheless, mutants lacking just the cytosolic tail (residues 187 to 199) were unable to caus

142 al change unveils a region of the N-terminal cytosolic tail targeted by the Art1 alpha-arrestin, whic

143 ast protein Ist2 contains an ER domain and a cytosolic tail that binds the plasma membrane and partic

144 Each of these proteins contains a cytosolic tail that binds to sorting nexin Snx3.

145 th the length of the stretch of the cadherin cytosolic tail that is in contact with the ARM region.

146 that bears wild-type or mutated CD28 in its cytosolic tail that is incapable of binding to Lck, phos

147 les with various point mutations in the CD28 cytosolic tail, the present study documents that in vivo

148 peting LC-CoAs disrupted binding of the NHE1 cytosolic tail to PI(4,5)P2.

149 ecruitment of alpha-catenin, and linking its cytosolic tail to the transmembrane domain.

150 Interestingly, all of the cytosolic tail truncated TEM8 mutants functioned as PA r

151 hermore, a single point mutation in the CD28 cytosolic tail (tyrosine 188) interferes with the abilit

152 eported to be tyrosine phosphorylated in the cytosolic tails under specific stimulation conditions.

153 HC I HC lacking its transmembrane domain and cytosolic tail uses the same ERAD components and is degr

154 n RAGE was deleted or transactivation of its cytosolic tail was inhibited.

155 lass I mutant lacking lysine residues in its cytosolic tail was ubiquitinated and degraded in the pre

156 olic tail, a region divergent from the CXCR2 cytosolic tail, was essential for IL-8 to induce Pi upta

157 nged when either the core amino acids of the cytosolic tail were deleted or the sequence and length o

158 Both proteins were tagged at their cytosolic tails with RRR and KKXX motifs, respectively,

159 horylation of tyrosine-based motifs in their cytosolic tail, with intrinsic disorder as a common feat