ライフサイエンスコーパス: cytotoxic effect

1 ancer cells specifically but also to enhance cytotoxic effect.

2 cells via RME in the first 24 h period exert cytotoxic effect.

3 with sonosensitizers to produce a localized cytotoxic effect.

4 ose simultaneous inhibition elicits a potent cytotoxic effect.

5 e trimeric form of TNFalpha and enhances its cytotoxic effect.

6 depend on the presence of oxygen to elicit a cytotoxic effect.

7 Accumulation of NO may cause cytotoxic effects.

8 il extracellular traps and are known to have cytotoxic effects.

9 f the retinal pigment epithelium and display cytotoxic effects.

10 HCV-specific CD8 T cells with antiviral and cytotoxic effects.

11 group at C44 as a critical feature for PLTXs cytotoxic effects.

12 rted for the latter may be due to off-target cytotoxic effects.

13 re biological functions while preventing its cytotoxic effects.

14 an improved physicochemical profile without cytotoxic effects.

15 ving dentin bridge formation without causing cytotoxic effects.

16 8 h), and this effect may produce additional cytotoxic effects.

17 malignant T-cell proliferation with minimal cytotoxic effects.

18 but no further antibacterial, antifungal nor cytotoxic effects.

19 e abraded particles did not induce any acute cytotoxic effects.

20 ped from the phagocyte, exerting significant cytotoxic effects.

21 e to penetrate into cells without triggering cytotoxic effects.

22 l of mammalian cells, where they exert their cytotoxic effects.

23 ered aquaporin-0 activity without detectable cytotoxic effects.

24 both fibrils and oligomers and the resulting cytotoxic effects.

25 in NIH3T3 mouse fibroblasts, do not produce cytotoxic effects.

26 ein aggregates and protects cells from their cytotoxic effects.

27 ive and marker-independent assessment of the cytotoxic effects.

28 to reach the cytosol, where they exert their cytotoxic effects.

29 ovel therapeutic strategy to alleviate their cytotoxic effects.

30 lls with hOCT1 enhanced sorafenib uptake and cytotoxic effects.

31 ne, cis- p-menthan-3-one, and estragole show cytotoxic effects.

32 coffee infusions at the highest dose without cytotoxic effects (500mug/mL) significantly prevented th

33 Compounds 9c and 9e revealed effective cytotoxic effects after 72 h of incubation in both normo

34 ments demonstrated that mP-PTX has a similar cytotoxic effect against A2780 cells as free PTX and P-P

35 ionophores, displayed a potent and selective cytotoxic effect against EMT-like cells.

36 ent is thought to depend on a direct initial cytotoxic effect against infected tumor cells and subseq

37 s, AptNAs were demonstrated to have specific cytotoxic effect against leukemia cells.

38 ll extracts showed a phenolic dose-dependent cytotoxic effect against MDA-MB-435, weak activity again

39 he cellular microtubule network, and exert a cytotoxic effect against multiple cancer cell lines.

40 and long-term antibacterial activity without cytotoxic effect against the pulp fibroblasts.

41 ypes can be added to the list of fruits with cytotoxic effects against breast cancer cells while not

42 Moreover, they have shown strong cytotoxic effects against cancer cell lines.

43 Ti particles exerted cytotoxic effects against fibroblasts, whereas surfaces

44 hat FV-specific CD4+ T cells indeed mediated cytotoxic effects against FV epitope peptide loaded targ

45 roliferation of human cancer cells with less cytotoxic effects against normal mouse epidermal cells.

46 lular HDACs in a pan-HDAC assay but enhanced cytotoxic effects against the human cancer cell lines A2

47 rBbKIm shows selective cytotoxic effect and angiogenesis inhibition against pro

48 th Irgafos 168 led to a significantly strong cytotoxic effect and PP prepared with Irganox 1076 induc

49 CM and LBG hydrolysates (1 mg/mL) have shown cytotoxic effect and reduced cell viability of Caco-2 ce

50 GCCNP had no cytotoxic effect and showed improvements on dry eye dise

51 aBalpha degradation and enhanced Dox-induced cytotoxic effects and apoptosis in all breast cancer cel

52 tion could be detected in samples exhibiting cytotoxic effects and at cytotoxic levels of analyzed es

53 ACEE produced dose-dependent cytotoxic effects and induced apoptosis in Lewis lung ca

54 estigate mensacarcin's unique cytostatic and cytotoxic effects and its mode of action.

55 anocarriers for long periods of time with no cytotoxic effects and no noticeable influence on embryog

56 creened 8 commercially available statins for cytotoxic effect, anti-TB activity, synergy with first-l

57 The cytotoxic effect appeared to be mediated by induction of

58 Antiangiogenic and cytotoxic effects are considered the principal mechanism

59 -tumor antibodies must be optimized for both cytotoxic effects as well as hFcgammaRIIA engagement on

60 Test compounds showed cytotoxic effects at concentrations comparable to or hig

61 clearly distinguishable from cytostatic and cytotoxic effects at higher drug concentrations and long

62 cell lines, revealing that Pvfp-5beta has no cytotoxic effects at the protein concentrations used and

63 film formation, namely: initial adhesion and cytotoxic effect, biofilm accumulation, susceptibility t

64 Augmentation of cisplatin's biochemical and cytotoxic effects by amino acid deprivation suggest that

65 These molecules exert cytotoxic effects by binding to DNA through various mech

66 e persistent organic pollutants which elicit cytotoxic effects by inducing reactive oxygen species ge

67 ) SEL1L down-modulation synergy enhances VPA cytotoxic effects by influencing GSCs proliferation and

68 g., quinazolinediones, QDs) that exert their cytotoxic effects by modulating ROS-mediated cell signal

69 No cytotoxic effects caused by EMD were detected.

70 , all surfaces with ChA residues showed some cytotoxic effect compared with controls (P <0.05).

71 herapy resulted in a significantly increased cytotoxic effect compared with reovirus monotherapy and

72 The cytotoxic effects depend directly on the drug's ability

73 own, that the presented device is capable of cytotoxic effect detection and estimation of cell viabil

74 In addition, the cytotoxic effects, determined as reactive oxygen species

75 sion of LGP2 leads to enhanced IFNbeta, (ii) cytotoxic effects following IR correlated with expressio

76 9 and the parent molecule 1 are similar, the cytotoxic effect for compound 9 was, as planned, markedl

77 eration of Caco-2 cell lines, exhibiting non-cytotoxic effect for HIMEC non-malignant endothelial cel

78 y, allowing the achievement of both heat and cytotoxic effects from a single platform.

79 delta T cells, however, and to overcome this cytotoxic effect gammadelta T cells were genetically mod

80 wever, inadequate local retention and severe cytotoxic effects have limited the clinical use of ionic

81 OHT) can exert estrogen receptor-independent cytotoxic effects have prompted the initiation of clinic

82 se segments possess different structures and cytotoxic effects, however, both can seed full-length hI

83 wn that the treated melanin and LiP have low cytotoxic effects; however, the mediator of veratryl alc

84 ernatin binding and confer resistance to its cytotoxic effects, implicating the adjacent hydrophobic

85 he PD-1/PD-L1 pathways and has antiviral and cytotoxic effects.IMPORTANCE We developed several novel

86 ata indicate that PT exhibited a more potent cytotoxic effect in Caco-2 compared to HCT-116 cells.

87 th significant increases of Dox delivery and cytotoxic effect in cancer cells.

88 The compound does not exhibit any cytotoxic effect in HEK293 cells and displaces the BRD9

89 d BH3 mimetics had a profound, BIM-dependent cytotoxic effect in PIK3CA-mutant cancer cells while spa

90 elinexor and ibrutinib elicits a synergistic cytotoxic effect in primary CLL cells and increases over

91 has 80.83% of antioxidant activity, without cytotoxic effect in vitro.

92 d enhanced cellular interactions, uptake and cytotoxic effects in breast cancer cells in vitro.

93 al ribonucleotide metabolism to elicit their cytotoxic effects in C. elegans rather than by thyminele

94 lymer demonstrated significant apoptotic and cytotoxic effects in C6 GBM cells.

95 ntrations in tissues, and exhibits selective cytotoxic effects in cancer cells through peroxide forma

96 derlying mechanism(s) by which PT exerts its cytotoxic effects in CRC cells.

97 PP induced cytotoxic effects in CSCs and prevented metastasis forma

98 Selective inhibition of HDAC6 does not show cytotoxic effects in healthy cells, normally associated

99 Correspondingly, C-miR146a induced cytotoxic effects in human MDSL, HL-60, and MV4-11 leuke

100 hich LEN, acting through CRBN and IKZF1, has cytotoxic effects in MDS and AML that depend on a calciu

101 The inhibitors show robust cytotoxic effects in multiple cancer cell lines and indu

102 ent of LAAO in dermonecrosis in mice and its cytotoxic effects in normal human keratinocytes, the maj

103 d aggregates have been demonstrated to exert cytotoxic effects in several diseases.

104 ells, while resulting in significantly lower cytotoxic effects in telomerase-negative cell lines when

105 substances are responsible for antiviral and cytotoxic effects in the medicinal plant extracts.

106 ionic and targets the mitochondria to induce cytotoxic effects in tumor cells, albeit not very effect

107 ylsulfanyl derivatives exerted submicromolar cytotoxic effects in vitro against a panel of cancer and

108 n treatment with BBI and TKI led to superior cytotoxic effects in vitro and in vivo, with BBI prevent

109 ith efficient internalization, efficacy, and cytotoxic effects in vitro Pharmacokinetic analyses in m

110 platinum resulted in the potentiation of the cytotoxic effect, indicating that macitentan can enhance

111 l treatment, which can integrate with direct cytotoxic effects induced by radiation or chemotherapy t

112 We found that MLN9708 had cytotoxic effects, induced autophagy and MKP-1 expressio

113 of various fibril polymorphs with differing cytotoxic effects is essential for determining how the a

114 hanism of action by which MDA-5 exerts these cytotoxic effects is unclear.

115 eads to increased free FA content, which has cytotoxic effects leading to cell death.

116 The mechanism involved in the cytotoxic effect may be associated with induction of apo

117 To our knowledge this is the first report on cytotoxic effects mediated by chondroitin sulfate/dermat

118 f the tumor microenvironment and confirm the cytotoxic effects observed by EMP2 treatment in vivo.

119 We hypothesized that in addition to the cytotoxic effects observed in cancer cells Amiodarone al

120 e not detected in patient's fibroblasts, the cytotoxic effect of AIr on various cell lines was demons

121 The cytotoxic effect of anticancer drugs doxorubicin (DOX),

122 d inhibition of JNK activity antagonized the cytotoxic effect of both compounds.

123 nsitivity of the ovarian cancer cells to the cytotoxic effect of cDDP by regulating expression of the

124 elective dCTPase inhibitors that enhance the cytotoxic effect of cytidine analogues in leukemia cells

125 The cytotoxic effect of disulfiram was maximal when administ

126 dependent efflux significantly increases the cytotoxic effect of doxorubicin (combination index, <0.9

127 drial MRP-1-dependent efflux activity on the cytotoxic effect of doxorubicin was investigated by coun

128 ntify conditions that enhance or prevent the cytotoxic effect of edelfosine, we have conducted genome

129 In erythrocytes, the cytotoxic effect of HlyA is strongly amplified by P2X re

130 thylates the RNA of Y. ruckeri to reduce the cytotoxic effect of holomycin during holomycin productio

131 ed the concentration-dependent (0.1-1 mg/mL) cytotoxic effect of Ketamine and reflect a loss in expre

132 FNalpha/beta treatment strongly enhances the cytotoxic effect of MEK inhibition, but only in cell lin

133 the efficacy of gene therapy by reducing the cytotoxic effect of misfolded mutant RPE65s.

134 The cytotoxic effect of monensin was not blocked by inhibito

135 We hypothesized a local cytotoxic effect of NET-related histone release in necro

136 The cytotoxic effect of our most relevant candidate was asse

137 The cytotoxic effect of pcm in MCF-7 cells was potentiated u

138 RK) pathway is partially responsible for the cytotoxic effect of phenformin.

139 into how we might measure the genotoxic and cytotoxic effect of plasma jet treatments (both indirect

140 These findings suggest that the direct cytotoxic effect of Shiga toxin 2 in the thalamus might

141 mice intoxicated with Stx2a and reduced the cytotoxic effect of Stx2a on Vero cells.

142 D mutation) protects cells and mice from the cytotoxic effect of TNF in conditions of IKK inhibition.

143 f drug treated cells are studied to evaluate cytotoxic effect of ZD6474 and also to assess the freque

144 ferent geometries commonly used to study the cytotoxic effects of (64)Cu.

145 e present study aims at elucidating possible cytotoxic effects of 2 commonly used rATG preparations o

146 ncreased the sensitivity of the cells to the cytotoxic effects of 6-MP by more than 7-fold.

147 a protective mechanism against ROS-triggered cytotoxic effects of a cocktail of pollutants in Caco-2

148 A assay that measures cell response to the cytotoxic effects of a methylating agent can determine t

149 to be a powerful agent to enhance the tumor cytotoxic effects of Abraxane and to reduce its off-targ

150 otecting the photoreceptor cells against the cytotoxic effects of accumulated all-trans-retinal.

151 mitochondrial dysfunction resulting from the cytotoxic effects of accumulated amyloid beta (Abeta).

152 encing of Chk2 rescues cancer cells from the cytotoxic effects of apoptin.

153 ADCC assays confirmed the cytotoxic effects of ARGX-111 in multiple human cancer c

154 and primary astrocytes, that the anticancer/cytotoxic effects of ascorbate are completely abolished

155 astin phenocopied xCT-KO and potentiated the cytotoxic effects of both gemcitabine and cisplatin in P

156 to 100 nM), prior to injury, attenuated the cytotoxic effects of BSI and preserved neurite length si

157 ted macrophages (TAM) are known to limit the cytotoxic effects of chemotherapy in preclinical models

158 However, recent evidence has linked the cytotoxic effects of chemotherapy with the de novo elici

159 ey role in helping cancer cells to evade the cytotoxic effects of chemotherapy, but also in protectin

160 ors suppress cancer cell growth, enhance the cytotoxic effects of cisplatin and inhibit tumour growth

161 omologous DNA repair efficiency and enhanced cytotoxic effects of cisplatin in NSCLC cells.

162 tantly, these compounds did not abrogate the cytotoxic effects of cisplatin on human cancer cells.

163 ls were able to shield living cells from the cytotoxic effects of CNTs, allowing biofilm formation to

164 Because the cytotoxic effects of conventional chemotherapies often h

165 nd HEK293 cells conferred sensitivity to the cytotoxic effects of Cry3A toxins.

166 BER counters the mutagenic and cytotoxic effects of damage that occurs continuously to

167 oma were significantly more resistant to the cytotoxic effects of DNA replication stress-inducing dru

168 TNBC cells and renders them resistant to the cytotoxic effects of doxorubicin both in vitro and in vi

169 In addition, AZD3463 enhanced the cytotoxic effects of doxorubicin on NB cells.

170 ontribute significantly to resistance to the cytotoxic effects of EGFR inhibition.Significance: Three

171 s study are to investigate proliferative and cytotoxic effects of EMD on oral epithelial cells and th

172 Cytotoxic effects of EMD treatment were sampled by lacta

173 oxygenase 1 induction, by counteracting the cytotoxic effects of engulfed RBC breakdown products, in

174 or elucidating the mechanisms underlying the cytotoxic effects of environmental toxicants.

175 teraction may prove useful in preventing the cytotoxic effects of ExoU to mitigate the virulence of P

176 chaperone proteins is required to avert the cytotoxic effects of free haem, but the constituents of

177 all cell lung carcinoma (NSCLC) cells to the cytotoxic effects of GMX.

178 Direct cytotoxic effects of H2O2 on PC12 in presence and absenc

179 HSP72 by minimizing the cell death caused by cytotoxic effects of heat.

180 ere, we show that fibroblasts counteract the cytotoxic effects of HER2 kinase-targeted therapy in a s

181 eased the vulnerability of beta cells to the cytotoxic effects of hIAPP.

182 pha inhibitor protein (IAIP) neutralizes the cytotoxic effects of histones and decreases histone-indu

183 a is crucial, protecting against potentially cytotoxic effects of HMGL activity while it transits to

184 NG-41 sensitized bladder cancer cells to the cytotoxic effects of human immune effector cells.

185 and ex vivo assays were applied to evaluate cytotoxic effects of IL-1beta on choroidal endothelium.

186 ory cytokines are well characterized, direct cytotoxic effects of invading immune cells on the ischem

187 rowth factor receptor (EGFR) can enhance the cytotoxic effects of ionizing radiation (IR).

188 bition of FGFR1 synergistically enhanced the cytotoxic effects of ionizing radiation and cisplatin.

189 es that pharmacologic ascorbate enhances the cytotoxic effects of ionizing radiation as seen by decre

190 The cytotoxic effects of Ir(III)-PPY nucleoside are both tim

191 st that epigenetic therapies may restore the cytotoxic effects of irradiation in radioresistant CSC p

192 doxorubicin nor mitomycin C potentiated the cytotoxic effects of ischemia.

193 The cytotoxic effects of isofuranodiene towards rat neuronal

194 e attenuated ROS production and reversed the cytotoxic effects of K-Ras(G12V) in the TKO MEFs.

195 r recycling that protects PDA cells from the cytotoxic effects of KRAS pathway inhibition.

196 forts have been made to investigate possible cytotoxic effects of metallic nanoparticles (NPs).

197 increased ROS and GSH depletion underlie the cytotoxic effects of METH in the cells.

198 r subtypes of breast cancer, to validate the cytotoxic effects of MLN9708, alone and in combination w

199 have analyzed the impact of lidocaine on the cytotoxic effects of MMC in this setting.

200 r, functional inhibition of SMO enhances the cytotoxic effects of NF-kappaB inhibitor.

201 ights into the estrogen receptor-independent cytotoxic effects of OHT by studying how it kills MPNST

202 We report cytotoxic effects of oligomeric and conformation-specifi

203 In this study, we investigated the cytotoxic effects of p28 treatment alone and in combinat

204 xel and suggests trastuzumab accelerates the cytotoxic effects of paclitaxel.

205 These findings provide insight into the cytotoxic effects of PARP inhibition, and point at combi

206 tial of this type of assays by examining the cytotoxic effects of phenylarsine oxide (PAO) and cyclop

207 For monitoring the acute cytotoxic effects of photoimmunotherapy before the tumor

208 ttle research on the potential genotoxic and cytotoxic effects of plasma jet treatment.

209 Hence, the antimicrobial and cytotoxic effects of pomegranate husk were examined and

210 n a panel of cancer cell lines abolished the cytotoxic effects of rapalogs.

211 Mechanistic studies indicate that the cytotoxic effects of SGN-CD33A involve DNA damage with e

212 Cytotoxic effects of SQ-CDDP NP were assessed in human c

213 mechanisms that enable cells to tolerate the cytotoxic effects of sunitinib.

214 glioblastoma patients as an enhancer of the cytotoxic effects of temozolomide and radiotherapy.

215 ozide to inhibit ID1 expression enhanced the cytotoxic effects of temozolomide therapy on glioma cell

216 lity to protect alpha7-expressing cells from cytotoxic effects of the alpha7 agonist choline in combi

217 to become mature, and thus resistant to the cytotoxic effects of the Bcl-2 inhibitor.

218 eration of L-428 and U-HO1 cells and reduced cytotoxic effects of the chemotherapeutical agents gemci

219 Cytotoxic effects of the combination of the food compone

220 tumor ether lipids (L-GAELs) that retain the cytotoxic effects of the D-GAELs including the ability t

221 The cytotoxic effects of the mutant and wild-type proteins w

222 Cytotoxic effects of the PB cocktail occurred at lower c

223 s study provides the first evaluation of the cytotoxic effects of the recently identified palytoxin (

224 alities by virtue of diminishing many of the cytotoxic effects of these mutant prion proteins (PrPDel

225 Thus, in CLL, the cytotoxic effects of Tnv-6 result from dysregulation of

226 Many studies highlighted the cytotoxic effects of various NP, including titanium diox

227 providing a means for LSCs to circumvent the cytotoxic effects of ven/aza therapy.

228 evidence of EdU uptake, indicating that the cytotoxic effects of vincristine took place during G1 Co

229 Specifically, the cytotoxic effect on Caco-2, HeLa (cancer) and MDCK (non-

230 sosomal iron that is utilized by ART for its cytotoxic effect on cancer cells.

231 with anticancer drug ZD6474 to evaluate the cytotoxic effect on cellular electrical behaviour using

232 These nanosystems did not show any cytotoxic effect on cultured cardiomyocytes.

233 sulfate GAGs derived from HCC70 cells had a cytotoxic effect on HCC70 cells and CCD-1095Sk cells.

234 rized myeloid cell supernatants had a direct cytotoxic effect on human A2B5(+) neural progenitors, re

235 We conclude that EA has a potent cytotoxic effect on human synovial sarcoma cells which i

236 of tumor cells within the bone marrow and a cytotoxic effect on isolated cells due to the high LET (

237 MMC cytotoxicity and exhibited a significant cytotoxic effect on its own.

238 bitory concentration, FIT-039 did not have a cytotoxic effect on mammalian cells.

239 in enhanced proteasome inhibition and robust cytotoxic effect on MM cells when BTZ was administered t

240 mononuclear cells (PBMCs) and evaluate their cytotoxic effect on monocytes.

241 In addition to its direct cytotoxic effect on the cancer cell, radiotherapy can sh

242 Ad5Delta24 exerted a potent, dose-dependent, cytotoxic effect on tumor cells, whereas CAR-T cells spe

243 apsulated doxorubicin and paclitaxel exhibit cytotoxic effects on 4T1 and PC3-luc cells, respectively

244 f the assayed bacteria, while not presenting cytotoxic effects on a non-tumour primary cell culture.

245 We previously found that IGFBP-3 exerts its cytotoxic effects on A549 (p53 wild-type) cell survival

246 rain K279a, as well as the morphological and cytotoxic effects on A549 cells.

247 ichia coli, and Staphylococcus aureus; their cytotoxic effects on A549, NCI-H441, small airway epithe

248 ltiple DNFA enzyme inhibitors, exerts potent cytotoxic effects on both BRAFi-sensitive and -resistant

249 Concentrations higher than 5 muM elicited cytotoxic effects on both cell lines, while a dose of 1

250 Melanoidins did not exert cytotoxic effects on Caco-2 and HUVEC cells (viability w

251 ypharmacological agents through multipronged cytotoxic effects on cancer cells.

252 ical assays of these novel structures showed cytotoxic effects on different cancer cell lines.

253 ssay was conducted to examine dose-dependent cytotoxic effects on drug-resistant and drug-sensitive c

254 Resolvin D1 had no cytotoxic effects on HGFs at concentrations between 1 an

255 ey are biocompatible and show no evidence of cytotoxic effects on hMSCs.

256 agliptin and saxagliptin, exhibited apparent cytotoxic effects on myeloma cell lines, without any dif

257 ion in adjacent pancreatic islets and direct cytotoxic effects on pancreatic islets.

258 rther show that in vitro TERT inhibition has cytotoxic effects on primary ALM cells.

259 PhIP and PhIP@OA did not show significant cytotoxic effects on SHSY5Y, MRC5, and human dermal fibr

260 Cytotoxic effects on TECs link the rATG-induced thymic d

261 The essential oils showed cytotoxic effects on tested human tumor cell lines, rela

262 t highlights the strong dependence of AgNPs' cytotoxic effects on their characteristics and tumor mod

263 Despite their exciting cytotoxic effects on tumor cells in vitro and antitumor

264 ion-associated gene 7 (MDA-7/IL-24) exhibits cytotoxic effects on tumor cells while sparing untransfo

265 the contribution of NKA inhibition to their cytotoxic effects on tumor cells.

266 inhibition of HuR had potent cytostatic and cytotoxic effects on tumor growth, and strongly suppress

267 ic doses of GC induce growth-suppressive and cytotoxic effects on various leukocytes including B cell

268 Thus, sodium arsenite may confer its cytotoxic effect partly through the aberrant activation

269 gested that thiopurine drugs may exert their cytotoxic effects partly through binding of (S)GTP to a

270 udies have demonstrated that, besides direct cytotoxic effects, poly(ADP ribose) polymerase (PARP) in

271 d to isolated compounds, which showed a weak cytotoxic effects, punicatannin C induced a moderate cyt

272 gations into the role of P2X4 in mediating a cytotoxic effect showed that only P2X7 expression in HEK

273 tumor-to-kidney ratio and a more pronounced cytotoxic effect than did (177)Lu-DOTATOC.

274 ngly, tyramine had a stronger and more rapid cytotoxic effect than histamine.

275 and histamine was associated with a stronger cytotoxic effect than was treatment with either BA or on

276 s displayed comparable antiproliferative and cytotoxic effects than the native doxorubicin because of

277 e with acute stress, but persistent SGs have cytotoxic effects that are associated with several age-r

278 ), into cells that elicited direct antitumor cytotoxic effects through nitric oxide synthase 2-mediat

279 he amyloid aggregation process per se exerts cytotoxic effects through the interaction of amyloid int

280 e invasiveness of breast cancer with minimal cytotoxic effects, thus departing from the cytotoxicity-

281 r IVIg contains anti-TKO pig antibodies with cytotoxic effect to pig cells.

282 0 nM/2 nM) inhibitor, demonstrated selective cytotoxic effect toward breast cancer gene 1 ( BRCA1)-de

283 Stem and leaf callus extracts exerted cytotoxic effects towards CCRF-CEM cells (stem: 13.1+/-0

284 son and the observed differences between the cytotoxic effects under microfluidic and static conditio

285 fic xenobiotic receptor inhibitor and has no cytotoxic effects up to 30 microM; 2) inhibits CAR-media

286 unds (HMF and furfural F) and cytoprotective/cytotoxic effects upon Caco-2 cells (MTT, cell cycle and

287 bolic enzymes on cccDNA synthesis but avoids cytotoxic effects upon long-term treatment.

288 lines are in the range of 25-45 muM, and no cytotoxic effect was observed on nontumorigenic (HEK-293

289 adhered to HeLa cells at low densities, and cytotoxic effects were discrete, supporting the view tha

290 LC50 = 47 +/- 8 muM), whereas no significant cytotoxic effects were observed for DPHP concentrations

291 No cytotoxic effects were observed in treated cells up to 0

292 Cytotoxic effects were observed only in CEH exposed to 5

293 y, NK cells were highly resistant to the TKI cytotoxic effect, were properly activated by immunostimu

294 eeding polyglutamine aggregation and exhibit cytotoxic effects when applied to neuronal cells.

295 primary patient blasts and observed superior cytotoxic effects when compared with other available FLT

296 nd that extracellular ATP itself has a small cytotoxic effect, whereas adenosine formed from ATP degr

297 vative and paclitaxel produced a synergistic cytotoxic effect, which was paralleled by an enhanced ap

298 /cytotoxicity assays indicate dose-dependent cytotoxic effects, which are inhibited by the nitric oxi

299 rate that the chemotherapy agent retains its cytotoxic effect, while the antibody maintains the abili

300 of novel approaches aiming to counteract its cytotoxic effects will be desirable to develop preventiv