ライフサイエンスコーパス: cytotoxin

1 onary Th17 response to the secretion of this cytotoxin.

2 e innocuous prodrug metronidazole (MTZ) to a cytotoxin.

3 ruginosa ExoU phospholipase A (PLA) secreted cytotoxin.

4 converting a nontoxic prodrug into a potent cytotoxin.

5 ases the effectiveness of a hypoxia-specific cytotoxin.

6 xicity, establishing ChA3 as a HIF-dependent cytotoxin.

7 ing of an FAP peptide substrate coupled to a cytotoxin.

8 Z were not damaged by H. pylori vacuolating cytotoxin.

9 ng or producing the virulence-enhancing ExoU cytotoxin.

10 exotoxin termed IL4(38-37)-PE38KDEL, or IL-4 cytotoxin.

11 less interesting as a selective hypoxic-cell cytotoxin.

12 ear to be unique among the large clostridial cytotoxins.

13 tes two-component-mediated expression of GBS cytotoxins.

14 antifungals, antihypercholesterolemics, and cytotoxins.

15 he type III secretion system with associated cytotoxins.

16 ent targeting of mammalian cells by type III cytotoxins.

17 mucosa with elaboration of enterotoxins and cytotoxins.

18 l distending toxin (CDT) family of bacterial cytotoxins.

19 diterpenoids that were reported to be potent cytotoxins.

20 irulence factors are two large glucosylating cytotoxins.

21 ytolytic pore-forming Repeats in ToXin (RTX) cytotoxins.

22 the approach was also used to compare native cytotoxin 3 (CTX III) and its scrambled isomer, another

23 uce two main cytotoxic proteins: Vacuolating cytotoxin A (VacA) and Cytotoxin-Associated gene A (CagA

24 The vacuolating cytotoxin A (VacA) is both essential and sufficient for

25 Its virulence factor vacuolating cytotoxin A (VacA) promotes more severe disease and gast

26 etes a pore-forming toxin called vacuolating cytotoxin A (VacA), which contains two domains (p33 and

27 n-vitro experiments showing that vacuolating cytotoxin A affect the regulation of T or B lymphocytes,

28 . pylori infection, and identify vacuolating cytotoxin A and cag pathogenicity island as the bacteria

29 rough many mechanisms, including vacuolating cytotoxin A and CagA activities, and may be predicted ba

30 H. pylori vacuolating cytotoxin A and cytotoxin-associated gene A protein inte

31 investigated the interaction of vacuolating cytotoxin A or cytotoxin-associated gene A with cells an

32 previously unknown mechanism of pore-forming cytotoxin action in which pathologic insults are not sol

33 Spores and cytotoxin activity were detected by 24 h postchallenge,

34 ), neutral red uptake (to detect vacuolating cytotoxin activity), and adhesion assays.

35 ions are the key determinants of vacuolating cytotoxin activity.

36 This multifunctional cytotoxin affects fundamental cellular processes such as

37 We found that BPSL1549 acted as a potent cytotoxin against eukaryotic cells and was lethal when a

38 bodies raised against the M. bovis hemolysin-cytotoxin also recognized a protein of approximately 98

39 tivated HSCs involved in NASH and that IL-13 cytotoxin ameliorates pathological features of NASH in r

40 liferation assays followed by CTL-associated cytotoxin analysis.

41 potential as a hypoxia-selective tumor-cell cytotoxin and is unlikely to cause major toxicity to wel

42 ells precluded additional evaluation of this cytotoxin and its role in ITx rejection.

43 Pneumolysin, a pore-forming cytotoxin and major virulence determinant, was both nece

44 pylori infection, including the vacuolating cytotoxin and the cag pathogenicity island.

45 which leads to accumulation of unconjugated cytotoxins and carcinogens in the bladder.

46 the parental mAb, including the addition of cytotoxins and imaging agents for medical applications.

47 bitory effects, revealing several new potent cytotoxins and leading to postulates regarding the molec

48 However, achieving conditional activity of cytotoxins and maintaining the toxin-expressing plants a

49 eparation, the disulfide linkages of several cytotoxins and PLA2 could be solved, including more than

50 d cytotoxins, the HpmA hemolysin, a secreted cytotoxin, and proteus toxic agglutinin (Pta), a surface

51 retion system (T3SS); the production of T3SS cytotoxins, and particularly ExoU, has been well establi

52 Lipopolysaccharide, urease, and vacuolating cytotoxin are among the factors that allow H. pylori to

53 These potent peptide cytotoxins are derived from a ribosomal precursor proces

54 Results for several cell types and 10 cytotoxins are presented here.

55 A cytotoxin-armed antibody reactive with one of these drug

56 for increasing the effectiveness of hypoxic cytotoxins, as it depends on the activation of HIF1 and

57 atients with discordant test results for the cytotoxin assay (CYT) and PCR assays.

58 of use; the enzyme immunoassay replaced the cytotoxin assay because of speed of results and technica

59 excretor (cytotoxigenic culture positive but cytotoxin assay negative) could be used to characterise

60 group 2, cytotoxigenic culture positive and cytotoxin assay negative; and group 3, both reference me

61 One antigen-negative sample positive by the cytotoxin assay only was deemed a false positive based o

62 gorised by reference method result: group 1, cytotoxin assay positive; group 2, cytotoxigenic culture

63 Toxin (cytotoxin assay) positivity correlated with clinical out

64 amycin, the standard diagnostic test was the cytotoxin assay, and standard management was to withdraw

65 e bacterium but no free toxin) than does the cytotoxin assay, which detects preformed toxin in faeces

66 ntre study, we did cytotoxigenic culture and cytotoxin assays on 12,420 faecal samples in four UK lab

67 The cytotoxin associated gene (cagA), the cagA-EPIYA and vac

68 The Cytotoxin associated gene A (CagA) protein of Helicobact

69 3, as well as Fur-mediated activation of the cytotoxin associated gene A, cagA (HPG27_507).

70 IV secretion system (cag-T4SS) to inject the cytotoxin-associated antigen A (CagA) into host cells ar

71 Recent work has identified genes of the cytotoxin-associated gene (cag) pathogenicity island (PA

72 The H. pylori cytotoxin-associated gene (cag) pathogenicity island enc

73 onstituent that augments disease risk is the cytotoxin-associated gene (cag) pathogenicity island, wh

74 land, cag, that encodes the effector protein cytotoxin-associated gene A (CagA) and a type four secre

75 We recently reported that expression of cytotoxin-associated gene A (CagA) and CagA-signaling mo

76 of H. pylori that carry the virulence factor cytotoxin-associated gene A (cagA) are much more likely

77 tes that the H. pylori virulence determinant cytotoxin-associated gene A (CagA) has a key oncogenic r

78 ysed for total IgE levels and anti-H. pylori cytotoxin-associated gene A (CagA) IgG antibody using co

79 horylation of the H. pylori virulence factor cytotoxin-associated gene A (CagA) in macrophages result

80 nically isolated H. pylori strain HP238, the cytotoxin-associated gene A (CagA) isogenic mutant strai

81 udy, we investigated the impact of H. pylori cytotoxin-associated gene A (CagA) on the modulation of

82 In this process, the virulence factor cytotoxin-associated gene A (CagA) plays a central role

83 he most potent H. pylori virulence factor is cytotoxin-associated gene A (CagA), which is translocate

84 pylori status groups: H. pylori-positive and cytotoxin-associated gene A (cagA)-positive (H. pylori+

85 Cytotoxin-associated gene A (cagA)-positive H. pylori st

86 by populations endemic versus nonendemic for cytotoxin-associated gene A (CagA)-positive Helicobacter

87 has been linked to the microbial oncoprotein cytotoxin-associated gene A (CagA).

88 proteins: Vacuolating cytotoxin A (VacA) and Cytotoxin-Associated gene A (CagA).

89 obacter pylori bacterial strains that inject cytotoxin-associated gene A (CagA).

90 Cytotoxin-associated gene A has been the subject of eleg

91 were not attributable to differences in the cytotoxin-associated gene A oncoprotein.

92 m antibodies to H. pylori in general and the cytotoxin-associated gene A protein (CagA) were measured

93 H. pylori vacuolating cytotoxin A and cytotoxin-associated gene A protein interact with multip

94 he interaction of vacuolating cytotoxin A or cytotoxin-associated gene A with cells and cell lines in

95 Infections with cytotoxin-associated gene pathogenicity island (cag PAI)

96 Pivi66 occurs in the cytotoxin-associated gene pathogenicity island, a genomi

97 The cytotoxin-associated gene pathogenicity island; the oute

98 HP isolates derives from harboring the cag (cytotoxin-associated genes) pathogenicity island (cagPAI

99 While PVL is usually viewed as a cytotoxin, at sublytic amounts it activates protective i

100 r quantitative cultures for C. difficile and cytotoxin B fecal filtrate concentrations.

101 vestigations are ongoing to identify optimal cytotoxin-based chemoradiotherapy platforms.

102 Stk1 positively regulates transcription of a cytotoxin, beta-haemolysin/cytolysin (beta-H/C) that is

103 lism, protein glycosylation, antibiotics and cytotoxins biosynthesis, siderophore biosynthesis, biolu

104 on to a brief synthesis of the actin-binding cytotoxin bistramide A.

105 microorganisms and plants, and is used as a cytotoxin by macrophages as part of the innate immune re

106 tic infections in humans, delivers bacterial cytotoxins by type III secretion directly into the host

107 sease is linked to the production of a large cytotoxin called the "multifunctional-autoprocessing RTX

108 cytosolic release of an entrapped nano-sized cytotoxin can be achieved with consequent improvement in

109 TcdB is a potent cytotoxin capable of inducing enzyme-independent necrosi

110 make ExoT into a highly versatile and potent cytotoxin, capable of inducing multiple forms of apoptos

111 Treatment of these rats with IL-13R-directed cytotoxin caused a substantial decline in fibrosis and l

112 IL-21 cytokines and perforin and granzyme B cytotoxins, CD4(+) NKT cells from mice deficient in thes

113 lysis by pneumococcal cholesterol-dependent cytotoxins (CDCs), including pneumolysin.

114 east cancer cells under the influence of the cytotoxin chloroacetaldehyde.

115 These results indicate that IL-4 cytotoxin combined with gemcitabine may provide effectiv

116 A targeted cytotoxin composed of IL-13 and mutated Pseudomonas exot

117 of gemcitabine with an interleukin-4 (IL-4) cytotoxin composed of IL-4 and truncated Pseudomonas exo

118 Based on this finding, a recombinant cytotoxin composed of IL13 ligand and a truncated form o

119 i extract or its immunomodulator vacuolating cytotoxin confers robust protective effects against alle

120 The interleukin-3 cytotoxin conjugate tagraxofusp was recently tested in p

121 Tagraxofusp (SL-401) is a CD123-directed cytotoxin consisting of human interleukin-3 fused to tru

122 vivo increased their sensitivity to IL-13PE cytotoxin consisting of IL-13 and a truncated form of Ps

123 Type III cytotoxins contribute to the ability of bacterial pathog

124 The combination of cytotoxin delivery and activation of innate and adaptive

125 by other methods that are efficient in their cytotoxin delivery to tumor with reduced dose-limiting t

126 ce-attached needle-like complex that injects cytotoxins directly into eukaryotic cells, causing cellu

127 macokinetic properties by conjugating potent cytotoxins directly to an antibody at a 4:1 or less stoi

128 ion of one of these Bicycles with the potent cytotoxin DM1 via a cleavable linker.

129 vascular disrupting agent, ICT-2552, and the cytotoxin doxorubicin.

130 cificity of monoclonal antibodies and potent cytotoxin drugs to achieve better therapeutic outcomes.

131 ufficient to elicit self-propagating amyloid cytotoxins during infection, (2) pulmonary endothelium c

132 n cytotoxicity comparable to the ER-targeted cytotoxin eeyarestatin I, and specifically inhibited pro

133 etone, (FFRck) followed by coupling with the cytotoxin EF24 and subsequently fVIIa to give EF-24-FFRm

134 Taxotere is a cytotoxin effective in treating breast and prostate canc

135 ed information on how ExoS or other type III cytotoxins enter and target intracellular host proteins.

136 Our results revealed the cytotoxins etoposide and ivermectin as potent inducers,

137 iated with acute infections express a potent cytotoxin, exoenzyme U (ExoU), that is delivered via the

138 including exotoxin A (ETA) and the type III cytotoxins (ExoS, ExoT, ExoU, and ExoY).

139 The Panton-Valentine leukocidin (PVL) is a cytotoxin expressed by many methicillin-resistant Staphy

140 oter by IS256 results in the derepression of cytotoxin expression and increased virulence.

141 ylori containing a cagA gene associated with cytotoxin expression may protect against the development

142 known member of the rare polytheonamide-type cytotoxin family as its product.

143 s, A and B, members of the large clostridial cytotoxin family.

144 t can be exploited for the release of potent cytotoxins from inactive prodrugs consisting of an FAP p

145 gene (cagA), the cagA-EPIYA and vacuolating cytotoxin gene (vacA) were typed by PCR and the cagA EPI

146 The vacuolating cytotoxin gene of Helicobacter pylori, vacA, induces cyt

147 group acquired mutations in the vacuolating cytotoxin gene vacA, resulting in loss of vacuolization

148 The cytotoxin gene was interrupted by extensive mutations an

149 e, cagA, and active forms of the vacuolating cytotoxin gene, vacA, are major determinants of pathogen

150 89, an uncharacterized paralogue of the vacA cytotoxin gene.

151 Ammonia/ammonium (A/A) is a cytotoxin generated by H pylori that kills gastric epith

152 in encodes Panton-Valentine leukocidin (PVL) cytotoxin genes, belongs to pulsed field gel electrophor

153 trains with nonsense mutations in chlamydial cytotoxins, guaBA-add, and a phospholipase D homolog dev

154 he heteromeric dimer of alpha-cobratoxin and cytotoxin has an activity similar to that of alphaCT-alp

155 n-Valentine leukocidin (PVL), a pore-forming cytotoxin, has garnered attention because of its epidemi

156 The staphylococcal pore-forming cytotoxins hijack important immune molecules but little

157 on of beta-hemolysin/cytolysin, an important cytotoxin implicated in facilitating GBS invasion.

158 We also showed that IL-4 cytotoxin in combination with gemcitabine exhibited syne

159 tion as an immunotherapeutic by delivering a cytotoxin in conjunction with activation of the immune s

160 The acquired biodata show that 1 is a potent cytotoxin in human tumor cell proliferation assays, dist

161 i.p. administration of IL-4 cytotoxin in mice with orthotopically implanted ovarian

162 n rat liver, indicating a novel role of this cytotoxin in potential therapy.

163 variety of signaling reactions, as well as a cytotoxin in the innate immune response.

164 es, IL-13 binding, and cytotoxicity of IL-13 cytotoxin in various cancer cell lines.

165 and NKT cell-derived perforin and granzyme B cytotoxins in promoting CD4(+) NKT cell atherogenicity.

166 To target IL-4R, we have developed IL-4 cytotoxin, in which circular-permuted IL-4 is fused to a

167 vestigate the sensitivity of cancer cells to cytotoxins, including anticancer drugs, we compare the p

168 Moreover, the cytotoxin induced edema in isolated lungs.

169 cells and isolated lungs were protected from cytotoxin-induced death by stimulation of signal transdu

170 considerable molecular knowledge of how this cytotoxin injures the host, the precise host response to

171 This cytotoxin is specifically and highly cytotoxic to PA-1,

172 esting that the additive effect of these two cytotoxins is critical during Proteus infection.

173 S. aureus alpha-hemolysin, a pore-forming cytotoxin, is an essential virulence factor in the patho

174 aphylococcal alpha-hemolysin, a pore-forming cytotoxin, is required for full virulence in a murine se

175 structures of a staphylococcal pore-forming cytotoxin, leukocidin GH (LukGH), in complex with its re

176 C. difficile colonization, lower intestinal cytotoxin levels and exhibited less severe clinical sign

177 he host defense, and that V. fischeri uses a cytotoxin-like molecule to induce host development.

178 eta42 peptide have been identified as potent cytotoxins linked to Alzheimer's disease, but the fundam

179 cell lines express receptors for IL-4, IL-4 cytotoxin may be a unique agent for the treatment of Hod

180 These results indicate that IL-4R-targeted cytotoxin may be a useful agent for the management of pa

181 oxic than the wild type, suggesting that the cytotoxins may be functional.

182 monoclonal antibody conjugated to the potent cytotoxin monomethyl auristatin E.

183 lated glycoprotein NMB (gpNMB) to the potent cytotoxin monomethyl auristatin E.

184 toxic agglutinin (Pta), a surface-associated cytotoxin, mutant analysis was used in conjunction with

185 Two of the cytotoxin mutants were less cytotoxic than the wild type

186 However, most PCR-positive/cytotoxin-negative patients did not have clear C. diffic

187 cost of isolating and treating PCR-positive/cytotoxin-negative patients.

188 d pneumolysin (HI-PLY), or antiserum against cytotoxin-negative pneumolysin (psiPLY).

189 tecting toxigenic C. difficile bacteria than cytotoxin neutralization (P = 0.0002).

190 imens were tested simultaneously by the cell cytotoxin neutralization assay (CCNA) and the Xpert C. d

191 test, to a toxigenic bacterial culture/cell cytotoxin neutralization assay (TBC/CCNA) for the detect

192 ested by the C. Diff Chek-60 GDH antigen and cytotoxin neutralization assays, the Tox A/B II ELISA, a

193 lutamate dehydrogenase (GDH) followed by the cytotoxin neutralization test (CYT) with a turnaround ti

194 ed by the C. Diff Chek-60 GDH antigen assay, cytotoxin neutralization, and Simplexa direct PCR.

195 Diff Chek-60 GDH antigen assay, cytotoxin neutralization, and Simplexa direct PCR.

196 ehydrogenase (GDH) antigen assay followed by cytotoxin neutralization.

197 ehydrogenase (GDH) antigen assay followed by cytotoxin neutralization.

198 ehydrogenase (GDH) antigen assay followed by cytotoxin neutralization.

199 roteinaceous receptors for several S. aureus cytotoxins now provides an explanation for the observed

200 xoenzyme T (ExoT) is a bifunctional type III cytotoxin of Pseudomonas aeruginosa that possesses both

201 Alpha-hemolysin (Hla), a pore-forming cytotoxin of S. aureus, has been identified through anim

202 acilitate cell binding and delivery of Yops (cytotoxins of Y. pestis), a novel interaction, distinct

203 The cytotoxic effect of IL-4 cytotoxin on H-RS cell lines was determined to be modera

204 pylori strains that express the vacuolating cytotoxin or the outer membrane protein OipA are similar

205 umab) or CD19 or CD20 and bound to different cytotoxins or immunotoxins are under development.

206 Targeting cell surface receptors with cytotoxins or immunotoxins provides a unique opportunity

207 The viral cytotoxin PB1-F2 contributed to the negative outcomes.

208 The potent cytotoxins pederin and psymberin have been prepared thro

209 teract with nitric oxide, forming the potent cytotoxin peroxynitrite.

210 Three potent cancer cell cytotoxins, piperazimycins A-C (1-3), have been isolated

211 occus aureus alpha-hemolysin (Hla), a potent cytotoxin, plays an important role in the pathogenesis o

212 ent of TLR4 and the Streptococcus pneumoniae cytotoxin pneumolysin.

213 453 amino acids) is a bi-functional type III cytotoxin produced by Pseudomonas aeruginosa.

214 (453 amino acids) is a bifunctional type III cytotoxin produced by Pseudomonas aeruginosa.

215 Shiga toxins (Stxs) are cytotoxins produced by the enteric pathogens Shigella dy

216 Shiga toxins (Stxs) are bacterial cytotoxins produced by the enteric pathogens Shigella dy

217 Polytheonamides are potent peptide cytotoxins produced by uncultivated bacteria that exist

218 considered to be the main reservoir for Vero cytotoxin-producing Escherichia coli (VTEC) O157, a caus

219 0.0% prevalence) both by PCR for tcdB and by cytotoxin production.

220 Continuous i.p. infusion of IL-4 cytotoxin prolonged survival of tumor-bearing mice even

221 The new functional cytotoxin quantitation method developed provides a valua

222 brane lipids were initially postulated to be cytotoxin receptor candidates.

223 about the underlying molecular mechanisms of cytotoxin-receptor interaction and host specificity.

224 apeutic delivery include temporal control of cytotoxin release, enzymatic activation of pro-drugs, an

225 In strain PAK, ExoS is the major cytotoxin required for colonization and dissemination du

226 as well as overexpression of SpvB, an actin cytotoxin required for Salmonella systemic survival.

227 onses in addition to inducing CTL-associated cytotoxin responses (perforin, granzyme A, granzyme B).

228 tratumoral treatment of these mice with IL-4 cytotoxin resulted in regression of the primary tumor ma

229 One sample produced nonspecific cytotoxin results.

230 The plant cytotoxin ricin enters target mammalian cells by recepto

231 alpha-hemolysin (HlyA), and Kingella kingae cytotoxin (RtxA).

232 significantly larger amounts of the secreted cytotoxins S. pyogenes NADase (SPN) and streptolysin O (

233 When 25A11 was coupled to the cytotoxin saporin either directly or via a secondary ant

234 ed glioma cells in vitro when coupled to the cytotoxin saporin either directly or via a secondary ant

235 ist-directed cell lesion in the RVM with the cytotoxin, saporin, using either CCK-saporin to target C

236 (RIPs) family (e.g. ricin, abrin) are potent cytotoxins showing a strong lethal activity toward eukar

237 reductase, which converts metronidazole to a cytotoxin, specifically in podocytes under the control o

238 Production of the cholesterol-binding cytotoxin streptolysin O (SLO) prevented internalization

239 r polysaccharide and/or large amounts of the cytotoxin streptolysin O (SLO).

240 Examples include the pore-forming cytotoxin streptolysin O, which oligomerises to form lar

241 rotein EGF-SubA, which combines EGF with the cytotoxin SubA that has been recently shown to selective

242 apsigargin, as tunicamycin and the subtilase cytotoxin SubAB from Shiga toxigenic Escherichia coli, w

243 Cleavage of BiP with the subtilase cytotoxin SubAB results in endoplasmic reticulum (ER) re

244 igenic Escherichia coli (STEC) use subtilase cytotoxin (SubAB) to interfere with adaptive immunity.

245 Subtilase cytotoxin (SubAB), produced by non-O157 type Shiga-toxig

246 Some LEE-negative STEC produce Subtilase cytotoxin (SubAB), which cleaves endoplasmic reticulum (

247 ty of the ribosome because it is targeted by cytotoxins such as alpha-sarcin and ricin that completel

248 Others invade cells or produce cytotoxins (such as those produced by Shigella, enteroin

249 Until recently, it was unclear how these cytotoxins targeted specific cell types for lysis.

250 Tracheal cytotoxin (TCT), a monomer of DAP-type peptidoglycan fro

251 Tracheal cytotoxin (TCT), a naturally occurring fragment of Gram-

252 me isoforms specifically cleave the tracheal cytotoxin (TCT), a peptidoglycan monomer released by end

253 B. pertussis virulence factor tracheal cytotoxin (TCT), a secreted peptidoglycan breakdown prod

254 egative bacteria through sensing of tracheal cytotoxin (TCT), whereas PGRP-LCy may have a minor role

255 Convergent total syntheses of the potent cytotoxins (+)-tedanolide (1) and (+)-13-deoxytedanolide

256 ds included enzyme immunoassay (EIA), direct cytotoxin testing, and two- and three-step algorithms us

257 njugates are better cross-linking agents and cytotoxins than acyclic conjugates.

258 (-)-Lomaiviticin A (1) is a C2-symmetric cytotoxin that contains two diazofluorene functional gro

259 gen secretes alpha-hemolysin, a pore-forming cytotoxin that contributes to the pathogenesis of pneumo

260 ,4-dioxide) is a promising hypoxia-selective cytotoxin that has shown significant activity in advance

261 Ipomoeassin F is a potent natural cytotoxin that inhibits growth of many tumor cell lines

262 Tirapazamine is a cytotoxin that selectively targets hypoxic cells.

263 Stxs are potent cytotoxins that are lethal to animals at low doses.

264 Many NLPs are cytotoxins that facilitate microbial infection of eudico

265 d to the production of a large repertoire of cytotoxins that target and kill innate immune cells, whi

266 To investigate the roles of two established cytotoxins, the HpmA hemolysin, a secreted cytotoxin, an

267 acts the plasma membrane to deliver type III cytotoxins through a channel formed by PopB, PopD, and P

268 latin/paclitaxel with or without the hypoxic cytotoxin tirapazamine in patients with advanced or meta

269 uppressed both C. difficile colonization and cytotoxin titers.

270 de moiety may be capable of delivering other cytotoxins to cancer cells.

271 ococcus aureus employs numerous pore-forming cytotoxins to injure host immune cells and promote infec

272 They are made by the chemical conjugation of cytotoxins to monoclonal antibodies, which can be achiev

273 These compounds were potent cytotoxins toward numerous pediatric cancer cell lines a

274 glycosylating Clostridium perfringens large cytotoxin (TpeL toxin) that is devoid of the CROP domain

275 ExoU is a potent Pseudomonas aeruginosa cytotoxin translocated into host cells by the type III s

276 ExoU, a cytotoxin translocated into host cells via the type III

277 l, 31 days) when they received systemic IL-4 cytotoxin treatment.

278 orter family of proteins, the putative large cytotoxin, type III secretion effectors, stress response

279 tamyl-transpeptidase GGT and the vacuolating cytotoxin VacA, are required and sufficient for asthma p

280 tamyl transpeptidase GGT and the vacuolating cytotoxin VacA, contribute critically and nonredundantly

281 proliferative epithelial cell signaling; the cytotoxin VacA, which causes epithelial damage; and an a

282 ly through its pro-apoptotic and vacuolating cytotoxin VacA.

283 The Helicobacter pylori toxin vacuolating cytotoxin (VacA) promotes gastric colonization, and its

284 The H. pylori vacuolating cytotoxin (VacA) recently has been shown to inhibit stim

285 bacter pylori secretes an 88-kDa vacuolating cytotoxin (VacA) that may contribute to the pathogenesis

286 The vacuolating cytotoxin, VacA, is an important virulence factor secret

287 . pylori MV with and without the vacuolating cytotoxin, VacA, which inhibits human T cell activity.

288 The tpeL gene encoding the large clostridial cytotoxin was localized to the cpb plasmids of some cpe-

289 This cytotoxin was self-propagating, was neutralized by anti-

290 IL-4 cytotoxin was specifically and highly cytotoxic [50% pro

291 This reaction generates potent cytotoxins which exceed the potency of asmarine A (1.2 m

292 g an innocuous cellular protein, Crk, into a cytotoxin, which interferes with integrin survival signa

293 GRP78 was depleted using the SubAB subtilase cytotoxin, which rapidly and specifically cleaves BiP/GR

294 nin (Pta) represents a novel autotransported cytotoxin with no bacterial homologues that works optima

295 ExoU is a potent cytotoxin with phospholipase A2 activity that causes rap

296 do not require the direct interaction of the cytotoxin with the organelle, and are independent of the

297 to the characterization of the erdasporines, cytotoxins with a novel carboxy-indolocarbazole TD subst

298 re, naturally occurring quinones can also be cytotoxins with antibacterial properties.

299 es such as contrast agents, radiotracers, or cytotoxins without interfering with the cell binding pro

300 dent synthesis and localization of the actin cytotoxin, YopE, were shown to be relaxed in DamOP cells