ライフサイエンスコーパス: dauer

1 a stress-resistant, quiescent stage called 'dauer'.

2 egans has an alternate dispersal life stage, dauer.

3 the developmentally arrested stage known as dauer.

4 alternative developmental phenotype known as dauer.

5 ce response to environmental stress known as dauer.

6 enter a migratory diapause stage, called the dauer.

7 ered locomotory and chemosensory behavior of dauers.

8 nimal cue) in nondauers to CO2 attraction in dauers.

9 or pathogens correlate with nonproliferating dauers.

10 actor DAF-16/FOXO to induce development into dauer, a diapause that withstands harsh conditions.

11 ng and stowing onto carrier animals, but how dauers acquire these behaviors, despite having a physica

12 age (Larva 1, Larva 2, Larva 3, Larva 4, and Dauer and adult) appears to be unique.

13 s much more pronounced in quiescent daf-2(-) dauer and dauer-like adult animals than in nondauaer ani

14 quired to promote VPC fate plasticity during dauer and for normal vulval patterning after passage thr

15 g lipid extracts of C. elegans larvae at the dauer and L3 stages that represent alternative developme

16 result the chemical characterization of the dauer and male attracting pheromones remained incomplete

17 8,042 genes differentially expressed during dauer and reproductive development and observed striking

18 We compared dauer and reproductive development using whole-animal RN

19 er-1 regulatory sequences, and is induced in dauers and at high temperatures.

20 We suggest that dauers and dauer-like quiescent adults may have underlyi

21 in many organisms, can stimulate movement in dauers and dauer-like quiescent adults.

22 ogenization of every larval stage, including dauers, and show that the Balch homogenizer can be used

23 end of number and abundance of glycans being Dauer approximately = L1 > adult approximately = L4 > L3

24 ike signaling functions in larvae to inhibit dauer arrest and acts during adulthood to regulate lifes

25 ompensation protein DPY-21 in the control of dauer arrest and DAF-2 ILS.

26 Thus, dosage compensation enhances dauer arrest by repressing X-linked genes that promote r

27 lso influences dosage compensation, promotes dauer arrest in part by repressing the X-linked ins-9 ge

28 The dauer arrest phenotype of eak-3 mutants is fully suppres

29 The influence of dosage compensation on dauer arrest, a larval developmental fate governed by th

30 f asm-3 extends animal lifespan and promotes dauer arrest, an alternative developmental process.

31 e, the long-lived growth arrest state called dauer arrest, in Caenorhabditis elegans.

32 In contrast to the well-studied dauer arrest, L1 arrest occurs without morphological mod

33 nto the intestinal lumen and degraded during dauer arrest, only to be secreted into the body cavity a

34 nsporters function redundantly in preventing dauer arrest, presumably by regulating the availability

35 ike XXX cells that are crucial in preventing dauer arrest, suggesting that it is involved in biosynth

36 tion of C. elegans homologous miRNAs reduced dauer arrest.

37 1 null mutant displays defects in inhibiting dauer arrest: it forms dauers in the deletion mutant bac

38 C. elegans is strongly induced to form dauers at temperatures above 26 degrees, near the upper

39 nditions induce a state of diapause known as dauer by inhibiting the conserved DAF-2 insulin-like sig

40 ssion of several X-linked genes that promote dauer bypass is elevated, including four genes encoding

41 ed ASI sensory neurons that are required for dauer bypass.

42 Previous research indicates that non-dauer C. elegans prefer to consume the virulent bacteria

43 as overexpression of LIN-42 can suppress the dauer constitutive phenotype of a ligand-insensitive daf

44 ins-9 repression in dauer-constitutive mutants requires DPY-21, SET-4 and th

45 we show that, independent of its role in the dauer decision, TGF-beta regulates the balance of prolif

46 ractive for the parasitic IJs and C. elegans dauers despite being repulsive for C. elegans adults, an

47 s to control adult phenotypic plasticity and dauer development and provide examples of modular genera

48 The RNA interference, dauer development, and programmed cell death pathways ar

49 rite arborization and axon remodeling during dauer development.

50 f the molecular mechanisms of the C. elegans dauer developmental decision has defined evolutionarily

51 ing in adults what has been observed for the dauer developmental decision of larvae.

52 regulated by DAF-2, including entry into the dauer developmental stage and aging.

53 enes, body size and entry into the alternate dauer developmental stage.

54 ife history traits, including entry into the dauer diapause and longevity.

55 -dafachronic acid (DA) promote bypass of the dauer diapause and proper gonadal migration during larva

56 omatic gonad and germline development during dauer diapause and recovery, and our finding that PTEN a

57 otein response (UPR) in promoting entry into dauer diapause and suggest that, in addition to cell-aut

58 -13 mutant exits L1 arrest and IIS-dependent dauer diapause faster than control worms, but is not inv

59 a key regulator of longevity, metabolism and dauer diapause in Caenorhabditis elegans.

60 ARD differs from the C. elegans dauer diapause in that it enables sexually mature adults

61 pathway, functions cell-intrinsically in the dauer diapause to arrest neuron morphological aging, and

62 adverse environments, animals arrest at the dauer diapause, a long-lived stress resistant stage.

63 through the second larval stage, worms enter dauer diapause, a state of global and reversible develop

64 s orphan nuclear receptor, DAF-12, regulates dauer diapause, reproductive development, fat metabolism

65 ditis elegans larvae by promoting entry into dauer diapause, which is characterized by metabolic and

66 n the ASI neuron pair, to promote entry into dauer diapause.

67 af-28(sa191), causes constitutive entry into dauer diapause.

68 choose between reproductive development and dauer diapause.

69 n to regulate longevity, stress response and dauer diapause.

70 long-lived, alternate organismal state, the dauer diapause.

71 dentities of pheromone signals that modulate dauer entry have been characterized.

72 We observe that the ascarosides that promote dauer entry of larvae also act on adult animals to atten

73 etic studies indicate that DAF-2B influences dauer entry, dauer recovery and adult lifespan by alteri

74 hat drive either reproductive development or dauer entry.

75 om its well-characterized role in preventing dauer entry.

76 cts as a component of a switch that mediates dauer entry.

77 g up-regulation of neuropeptide genes during dauer entry.

78 aviors dependent on the ASJ neurons, such as dauer exit and pathogen avoidance.

79 at a hormone signaling pathway, the abnormal DAuer Formation (DAF) 12 nuclear hormone receptor (NHR)

80 ate increased population density and promote dauer formation [1, 8-10].

81 identify bacterial components that influence dauer formation and aging in C. elegans, we utilized the

82 Consistent with its role in dauer formation and aging, we show that insulin/insulin-

83 IGF-1 signaling (IIS) pathway regulates both dauer formation and longevity.

84 nd biochemical pathways, including those for dauer formation and RNAi, are conserved.

85 s identify a new sensory pathway controlling dauer formation and shed light on ALK signaling, integra

86 Thus, male mating and dauer formation are linked through a common set of small

87 pak-1, nck-1, and ced-10 cause constitutive dauer formation at 27 degrees C, a phenotype also observ

88 on, we find that hbl-1 can also modulate the dauer formation decision in a complex manner.

89 through amphid neurons and actively inhibits dauer formation during reproductive developmental growth

90 Multigenic resistance to dauer formation has also arisen in high-density cultures

91 Genetic analysis of dauer formation has identified the involvement of evolut

92 A molecular and genetic analysis of dauer formation has revealed key insights into how senso

93 architecture of natural genetic variation in dauer formation has, however, not been thoroughly invest

94 iverse E. coli deletion mutants that enhance dauer formation in an insulin-like receptor mutant (daf-

95 basis of these results, male attraction and dauer formation in C. elegans appear as alternative beha

96 that OGT modulates macronutrient storage and dauer formation in C. elegans, providing a unique geneti

97 Dauer formation in Caenorhabditis elegans is a temperatu

98 e abundantly produced by one genotype induce dauer formation in other genotypes, but not necessarily

99 tein)-coupled receptors (GPCRs) that mediate dauer formation in response to a subset of dauer pheromo

100 controlling nutrient storage, longevity, and dauer formation in the C. elegans O-GlcNAc cycling mutan

101 To begin to investigate the evolution of dauer formation in the genus Caenorhabditis at the molec

102 nd that the oga-1(ok1207) knockout augmented dauer formation induced by a temperature sensitive insul

103 ng mediated by the opioid peptide NLP-24 and dauer formation mediated by pheromones.

104 e diapause of Drosophila melanogaster and in dauer formation of Caenorhabditis elegans suggests a con

105 t-2 specifically enhanced the daf-2-mediated dauer formation phenotype.

106 es named dafachronic acids (DAs) control the dauer formation program in Caenorhabditis elegans throug

107 cell fate decisions and those that regulate dauer formation promote the robustness of developmental

108 ;nlp-24 double mutants exhibited much higher dauer formation than seen in either of the single mutant

109 as at the higher concentrations required for dauer formation the compounds no longer attract males an

110 lic AMP, which extends lifespan and enhances dauer formation through the modulation of TGF-beta (daf-

111 2 function renders animals hypersensitive to dauer formation under stressful conditions, whereas mise

112 XX cells, which are implicated in regulating dauer formation via the daf-9 pathway.

113 gar ascarylose for developmental regulation (dauer formation), male sex attraction, aggregation, and

114 Dauer formation, a major nematode survival strategy, rep

115 Molecular pathways involved in dauer formation, an alternate larval stage that allows C

116 elegans, did not show any notable effect on dauer formation, DAF-16 localization, or DAF-16 downstre

117 on of lin-42 in the pre-dauer stage inhibits dauer formation, indicating that lin-42 acts as a negati

118 lin-like signaling pathway, is involved with dauer formation, longevity, and stress resistance.

119 ures associating them with processes such as dauer formation, male identity, sperm formation, and int

120 Here we show that by suppressing dauer formation, Rhabditis sp. SB347 develops into femal

121 elegans, the IGF-1R ortholog DAF-2 regulates dauer formation, stress resistance, metabolism, and life

122 pcm-1 mutation may inhibit autophagy during dauer formation, suggesting that the absence of protein

123 is responsible solely for the regulation of dauer formation, with no role in longevity regulation, w

124 ncluding fertility, reproductive timing, and dauer formation, yet each of these differed in their thr

125 e find that the type II BMP receptor, DAF-4 (dauer formation-defective-4), is retromer-independent an

126 10 quantitative trait loci (QTLs) affecting dauer formation.

127 regulated opioid signaling and then enhanced dauer formation.

128 d multigenic resistance to pheromone-induced dauer formation.

129 ns, which are required for pheromone-induced dauer formation.

130 lightly more potent than ascr#3 in promoting dauer formation.

131 inct from that which regulates longevity and dauer formation.

132 for activated STAT proteins in repression of dauer formation.

133 s, or stress response pathways that regulate dauer formation.

134 ns in which the ogt-1(ok430)-null diminished dauer formation.

135 hree of which are amphid neurons involved in dauer formation.

136 ctions, including life span, fat storage and dauer formation.

137 ulates macronutrient storage, longevity, and dauer formation.

138 the overexpression of opioid genes disturbed dauer formation.

139 del of intraspecific competition in nematode dauer formation.

140 habditis at the molecular level, we isolated dauer-formation mutations in C. briggsae, a species clos

141 ed reduced preference for S. marcescens, and dauers from some strains preferred E. coli to S. marcesc

142 nsidered "nonaging" because larvae that exit dauer have a normal life span.

143 elegans furin homolog KPC-1 is required for dauer IL2 dendritic arborization and dauer-specific nict

144 defects in inhibiting dauer arrest: it forms dauers in the deletion mutant backgrounds of ncr-1 or da

145 s an alternative developmental state, called dauer, in which glia and neurons of the amphid sensory o

146 By genetically delineating a dauer-independent rIIS ageing pathway, our results show

147 Overall, dauer individuals exhibited reduced mortality rates.

148 We found that dauer individuals exhibited reduced preference for S. ma

149 Here, we compared the preferences of dauer individuals from six strains of C. elegans to the

150 Collectively, we found evidence of dauer-induced parasite avoidance and reduced mortality i

151 Long-term daf-22 and dhs-28 cultures develop dauer-inducing activity by accumulating less active, lon

152 o endogenously produced small molecules, the dauer-inducing ascarosides ascr#2 and ascr#3, regulate l

153 responses to ascr#2, one of the most potent dauer-inducing ascarosides, although this mutant respond

154 nal consists of a synergistic blend of three dauer-inducing ascarosides, which we call ascr#2, ascr#3

155 d hermaphroditic development if submitted to dauer-inducing conditions.

156 determine the chemical composition of their dauer-inducing metabolomes and responses to individual p

157 Chemical and metabolomic analysis of dauer-inducing pheromone has identified a family of smal

158 Free-living nematodes excrete dauer-inducing pheromones that have been assumed to targ

159 of whether an animal undergoes continuous or dauer-interrupted development.

160 diates the choice between the continuous vs. dauer-interrupted life history.

161 utcrossing and the obligatory development of dauers into self-propagating adults.

162 The dauer is a dispersal stage with dauer-specific behaviors

163 The dauer is specialized for survival under harsh environmen

164 f developmental time by forming a long-lived dauer larva at the end of the second larval stage.

165 of hbl-1 and of genes encoding regulators of dauer larva formation, we find that hbl-1 can also modul

166 IGF-like pathway essential for longevity and dauer larva formation.

167 al quiescence (diapause), exemplified by the dauer larva stage of the nematode Caenorhabditis elegans

168 developmentally quiescent, stress-resistant dauer larva stage, enabling them to survive for prolonge

169 ipt through development, particularly in the dauer larva, a diapause stage associated with longevity.

170 an obligatory nonfeeding juvenile stage, the dauer larva.

171 ners in controlling the decision to become a dauer larva.

172 sient bottlenecks and ongoing dispersal as a dauer larva.

173 ethod, we profiled muscle gene expression in dauer larvae and aging worms, revealing gene expression

174 defects of pcm-1 mutants previously seen in dauer larvae and here in L1 larvae suggest a defect in t

175 tine regulate the appearance and behavior of dauer larvae and many aspects of developmental arrest of

176 To survive, C. elegans dauer larvae and stationary phase S. cerevisiae require

177 We found that dauer larvae and stationary phase yeast switched into a

178 Dauer larvae are characterized by the arrest of all prog

179 When dauer larvae are returned to favorable environmental con

180 Dauer larvae contained complex N-glycans with higher mol

181 o understand how the control of variation in dauer larvae development has evolved.

182 opeptide Y receptor homolog npr-1 can affect dauer larvae development in growing populations.

183 eport extensive natural genetic variation in dauer larvae development within growing populations acro

184 bditis elegans, the appropriate induction of dauer larvae development within growing populations is l

185 If dauer larvae encounter conditions favorable for resumpti

186 complex genetic architecture of variation in dauer larvae formation in C. elegans and may help to und

187 The OGT knockout suppresses dauer larvae formation induced by a temperature-sensitiv

188 bditis elegans arrest development by forming dauer larvae in response to multiple unfavorable environ

189 2 target genes and initiate development from dauer larvae into adults.

190 However, dauer versus non-dauer larvae mortality rates also varied significantly b

191 The method also allowed heritable changes in dauer larvae of Auanema, despite the immaturity of the g

192 Dauer larvae of the nematode Caenorhabditis elegans exhi

193 e development normally, indicating that post-dauer larvae possess mechanisms to accommodate an indefi

194 The formation of dauer larvae, a developmental state promoted by daf-16,

195 osyl Pc-glycan (Pc1dHex2Hex5HexNAc6) seen in Dauer larvae, have not been observed in any organism.

196 appendicularian mucous houses, and nematode dauer larvae, to serving as mechanotransducers in flies

197 Pc2Hex4HexNAc3, from Dauer larvae, when subjected to PSD MS analyses, showed

198 ites undergo a prolonged quiescent period as dauer larvae, which can endure for several months with p

199 ize, and egg laying and an inability to form dauer larvae.

200 storage, and a decreased propensity to form dauer larvae.

201 In addition, IFT can be observed in dauer larvae.

202 ively regulate formation of stress-resistant dauer larvae.

203 ed stage analogous to Caenorhabditis elegans dauer larvae.

204 f lyso-maradolipids specifically enriched in dauer larvae.

205 nt, paralyzes J2 larva, and inhibits exit of dauer larvae.

206 legans larvae to arrest as stress-resistant "dauer" larvae after the second larval stage (L2), thereb

207 one) that regulates entry into the alternate dauer larval stage and also modulates adult behavior via

208 o induce development of the stress-resistant dauer larval stage and to coordinate various behaviors.

209 ransiently pass through the stress-resistant dauer larval stage exhibit distinct gene expression prof

210 ditis elegans enters into a stress-resistant dauer larval stage in response to an adverse environment

211 d to trigger entry into the stress-resistant dauer larval stage, Caenorhabditis elegans uses the daue

212 ates the decision to enter into the enduring dauer larval stage.

213 for entry into the developmentally arrested, dauer larval stage.

214 evelopment and entering the stress-resistant dauer larval stage.

215 Here, we identify several consequences of dauer life history for VPC specification.

216 e pronounced in quiescent daf-2(-) dauer and dauer-like adult animals than in nondauaer animals.

217 inally, the number of BxPrx homologs in both dauer-like and fungi-feeding B. xylophilus were comparab

218 ke dafachronic acids induced recovery of the dauer-like iL3 in parasitic nematodes by activating orth

219 imilar up-regulation of neuropeptides in the dauer-like infective juveniles of diverse parasitic nema

220 ved in parasitic nematodes to regulate their dauer-like infective larval stage, and as such, the DAF-

221 We suggest that dauers and dauer-like quiescent adults may have underlying changes

222 anisms, can stimulate movement in dauers and dauer-like quiescent adults.

223 A similar dauer-like quiescent state is produced in adults by rela

224 bust lifespan extension unaccompanied by any dauer-like traits.

225 lays a central role in regulating life span, dauer, metabolism, and stress.

226 We also demonstrate that during dauer neuropeptides modulate the dauer-specific nictatio

227 se of Drosophila melanogaster and the larval dauer of Caenorhabditis elegans.

228 Prenol was attractive to dauers of some free-living nematodes and insect larvae.

229 ascarosides, control developmental diapause (dauer), olfactory learning, and social behaviors of the

230 ifficult under certain conditions, e.g. from dauer or aging worms.

231 dence suggested that the C. elegans TGF-beta Dauer pathway is responsible solely for the regulation o

232 ongevity-regulating activity by the TGF-beta Dauer pathway that is masked by an egg-laying (Egl) phen

233 The TGF-beta Dauer pathway's regulation of longevity appears to be me

234 rogram that is genetically distinct from the dauer pathway, and requires the Nrf (NF-E2-related facto

235 n epigenetic regulator and components of the dauer pathway.

236 Moreover, sta-1 mutants showed a synthetic dauer phenotype with selected TGF-beta mutations.

237 -chain fatty acid-derived side chains of the dauer pheromone and link dauer pheromone production to m

238 cellular pathways responsible for detecting dauer pheromone and temperature have been defined in par

239 rains, the desert strain fails to respond to dauer pheromone at 25 degrees C, but it does respond at

240 We found that these isolates produce dauer pheromone blends of different composition and resp

241 Furthermore, we show that the active dauer pheromone components that are produced by C. elega

242 e dauer formation in response to a subset of dauer pheromone components.

243 ut additional unidentified components of the dauer pheromone contribute to its activity.

244 Although the dauer pheromone has been studied for 25 years, its biosy

245 Several components of the dauer pheromone have been identified as derivatives of t

246 C. elegans constitutively secretes the dauer pheromone into its environment, enabling it to sen

247 e model organism Caenorhabditis elegans, the dauer pheromone is the primary cue for entry into the de

248 in Pristionchus pacificus revealed that the dauer pheromone of some strains affects conspecifics of

249 side chains of the dauer pheromone and link dauer pheromone production to metabolic state.

250 mutant is the only known mutant defective in dauer pheromone production.

251 Identification of dauer pheromone receptors will allow a better understand

252 de chain is a highly potent component of the dauer pheromone that acts synergistically with previousl

253 ture of small molecules (collectively termed dauer pheromone) that regulates entry into the alternate

254 based on sensing of environmental inputs and dauer pheromone, a small molecule signal that serves to

255 ta signaling, which mediates the response to dauer pheromone, but SCD-2 might mediate a nonpheromone

256 environmental stimuli, including exposure to dauer pheromone, food deprivation, and high temperature,

257 Identifying the active components of the dauer pheromone, the conditions under which they are pro

258 arval stage, Caenorhabditis elegans uses the dauer pheromone, which consists of ascaroside derivative

259 mponents of the density-dependent C. elegans dauer pheromone.

260 as a single mutant, it is hypersensitive to dauer pheromone.

261 increases the production of the most potent dauer pheromones, those with the shortest side chains, u

262 sting that it is involved in biosynthesis of dauer-preventing steroid hormones.

263 ide signaling promotes the decision to enter dauer rather than reproductive development.

264 indicate that DAF-2B influences dauer entry, dauer recovery and adult lifespan by altering insulin se

265 neurons and signaling pathways that control dauer recovery in Caenorhabditis elegans also control IJ

266 In a screen for dauer regulatory genes that control the activity of the

267 lays C. elegans ageing through activation of dauer-related processes during adulthood, but some rIIS

268 lifespan extension by even mild activity of dauer-related processes.

269 sory receptive endings of the AWC neurons in dauers remodel in the confines of a compartment defined

270 We map this defect in dauer response to a mutation in the scd-2 gene, which, w

271 is no correlation between production of and dauer response to a specific compound in individual stra

272 Abrogating quiescence in dauer results in post-dauer sterility.

273 Despite dauer's importance in nature, we know little of how it r

274 The dauer is a dispersal stage with dauer-specific behaviors for finding and stowing onto ca

275 cell autonomously in IL2 neurons to regulate dauer-specific dendritic arborization and nictation.

276 ral individual synapses, we demonstrate that dauer-specific electrical synapse remodeling is responsi

277 that during dauer neuropeptides modulate the dauer-specific nictation behavior (carrier animal-hitchh

278 red for dauer IL2 dendritic arborization and dauer-specific nictation behavior.

279 , whereas misexpression of lin-42 in the pre-dauer stage inhibits dauer formation, indicating that li

280 e, can induce C. elegans larvae to enter the dauer stage, a developmentally arrested diapause state.

281 ntrations induce developmental arrest at the dauer stage, an alternative, nonaging larval stage.

282 to enter the long-lived but non-reproductive dauer stage.

283 ve development over entry into the diapausal dauer stage.

284 stage, the non-feeding and highly persistent dauer stage.

285 ge under harsh environmental conditions, the dauer stage.

286 The Caenorhabditis elegans dauer state is a hibernation-like state of diapause that

287 In contrast, hypoxia, the dauer state, and high salt reduce touch sensitivity by p

288 rogating quiescence in dauer results in post-dauer sterility.

289 y-associated phenotypes including life span, dauer, stress resistance, and fat storage.

290 rmal vulval patterning after passage through dauer, suggesting that DAF-16/FoxO coordinates environme

291 phrodite and male animals indicates that the dauer suppression phenotype of dpy-21 mutants is due to

292 ecreased under conditions that do not induce dauer traits, SKN-1 most prominently increases expressio

293 delayed by interventions that do not involve dauer traits.

294 However, dauer versus non-dauer larvae mortality rates also varie

295 In wild-type dauers, VPCs undergo a phenomenon reminiscent of natural

296 s at various developmental stages (including dauer) were measured and different positions along the w

297 verexpression, we show that DAF-37 regulates dauer when expressed in ASI neurons and adult behavior w

298 itis elegans enters a diapause state, termed dauer, which is accompanied by remodeling of sensory neu

299 an alternative developmental stage known as dauer, which is characterized by adaptive changes in str

300 les (IJs) to those of Caenorhabditis elegans dauers, which are analogous life stages.