ライフサイエンスコーパス: daunting

1 But the complexity of the challenge remains daunting.

2 gnosing, and treating periorbital edema less daunting.

3 correlate structure and function have become daunting.

4 th very little programming experience can be daunting.

5 the less-defined course of an MD/MBA can be daunting.

6 xperimental and computational methods can be daunting.

7 nctional relationships has been particularly daunting.

8 , although the logistical considerations are daunting.

9 esource overhead made the scheme practically daunting.

10 challenging and make PIT program development daunting.

11 -throughput experimental design is even more daunting.

12 e the occurrence of this problem have proved daunting.

13 the development of this brain region rather daunting.

14 y under in vivo conditions, has proved to be daunting.

15 parameters that influence PE outcomes can be daunting.

16 ired qubit overhead and error thresholds are daunting.

17 following a career path into academia can be daunting.

18 of such loci, establishing causality remains daunting.

19 pplies and reagents for experiments can feel daunting.

20 ith more severe PE, has become progressively daunting.

21 community engagement infrastructure, can be daunting.

22 racterization of cAMP signaling compartments daunting.

23 ication, and thus, assay verification can be daunting.

24 ma that suggest the study of HERV RNA can be daunting.

25 acterium tuberculosis transmission, is quite daunting.

26 100 identified ASD-risk genes and regions is daunting, a growing armamentarium of comprehensive, larg

27 ively cumbersome experimental procedures and daunting analytical frameworks.

28 rug registration process, it will prove less daunting and more efficient in future academically spons

29 Eliciting information on the exposome is daunting and not feasible at present; the undertaking ma

30 aid, and getting accustomed to its use is a daunting and often frustrating process.

31 l processes underlying progression remains a daunting and ongoing challenge.

32 atterns at successive levels of processing-a daunting and seemingly intractable task.

33 eresting genes generated by these studies is daunting, and biological and clinical relevance of these

34 implest of molecules, is both remarkable and daunting, and presents intriguing new possibilities for

35 nt of PDH flux in exercising human muscle is daunting, and the net effect of covalent modification an

36 of serious suicidal behavior, explaining the daunting array of suicide-related facts from the molecul

37 rategies to accomplish this task would prove daunting as it is both time-consuming and costly.

38 nderstood and the selection of immunogens is daunting as there are dozens of surface proteins and two

39 China's health-equity challenges are truly daunting because of a vicious cycle of three synergistic

40 tralizing antibodies (NAbs) against HIV-1 is daunting because of the extensive genetic and antigenic

41 However, the road ahead is daunting because of the huge genetic diversity of phages

42 Policy development can be daunting because organizations may encounter various bar

43 on pipelines for a new genome project can be daunting because tools often only work in limited contex

44 Although the scale of this challenge is daunting, better methods for functional variant interpre

45 for analysis and interpretation, marking the daunting "big data era." In the biomedical field, this q

46 stainable Development Goal 2 (UN-SDG2), is a daunting but essential task, given the limited timeline

47 rge-scale efforts to tackle some of the most daunting but important neuroscience questions.

48 the knottier it appears to be, suggesting a daunting (but stimulating) path ahead for neuroscience m

49 ng under the hood" of an AI algorithm may be daunting, but understanding how it works at a foundation

50 gets' that predict adverse drug reactions is daunting by empirical methods alone.

51 cs with bubble dynamics is an important, yet daunting challenge because of the intrinsically complex

52 g domestic safety from terrorist attack is a daunting challenge because of the wide array of chemical

53 ributable to a specific electrical load is a daunting challenge but essential for many environmental

54 th analysis of the plasma proteome remains a daunting challenge due to its high complexity and the ex

55 lonal antibody (mAb) in tissues represents a daunting challenge due to the extremely low tissue level

56 nitoring of tumor drug delivery in vivo is a daunting challenge due to the heterogeneity and complexi

57 myo-inositol pyrophosphates (PP-InsPs) is a daunting challenge due to the large number of possible i

58 hrough the void spaces in porous metals is a daunting challenge for a variety of emerging interface t

59 g heat to and from conversion materials is a daunting challenge for a variety of innovative energy te

60 iant frontotemporal dementia (bvFTD) poses a daunting challenge for clinicians but will be critical f

61 onic cough is a common symptom that can be a daunting challenge for clinicians since treatment of the

62 Schizophrenia remains a daunting challenge for efforts aimed at identifying fund

63 and suppressed polarization still remains a daunting challenge for practical applications.

64 nked peptides by mass spectrometry remains a daunting challenge for protein-protein cross-linking app

65 ate species at a single crystal surface is a daunting challenge for spectroscopic techniques.

66 in a high-dimensional composition space is a daunting challenge for traditional trial-and-error exper

67 tification of promising HE alloys presents a daunting challenge given the associated vastness of the

68 of these associated complications, and is a daunting challenge given the high percentage of patients

69 le starting from a racemic mixture remains a daunting challenge in chemistry.

70 Lentiviruses such as HIV have a daunting challenge in gaining access to a new host predo

71 ated by this profiling technology presents a daunting challenge in terms of effectively visualizing a

72 regenerative biology presents a particularly daunting challenge in this regard.

73 human genome efficiently and accurately is a daunting challenge involving the duplication of upward o

74 the pervasive nature of genetic exchange, a daunting challenge is how best to infer the correct rela

75 he importance of in silico approaches to the daunting challenge of assigning and predicting the funct

76 , I present suggestions on how to tackle the daunting challenge of building truly national HIV/AIDS p

77 hnical challenge, in addition to the already daunting challenge of optimizing interlayer spacing, for

78 py for the muscular dystrophies represents a daunting challenge requiring significant advances in our

79 the cardiovascular system; thus, it seems a daunting challenge to build predictive models that accou

80 Bioterrorism poses a daunting challenge to global security and public health

81 However, it is a daunting challenge to identify an optimized condition wi

82 ntless efforts have been made, it is still a daunting challenge to organize different nanocomponents

83 It remains a daunting challenge to reconcile data as diverse as synap

84 supply of corrected progeny remains the most daunting challenge to the success of human gene therapy.

85 ing protein 2 (MeCP2) overexpression poses a daunting challenge to traditional biochemical-pathway-ba

86 or improved Li-S batteries, but represents a daunting challenge(4-6).

87 tion by using artificial receptors remains a daunting challenge, mainly because of the difficulties i

88 comprehensive microbial probe sets remains a daunting challenge, particularly in virology where rapid

89 fatty acid substrate site of InhA remains a daunting challenge.

90 zed precious metal-based catalysts remains a daunting challenge.

91 aphic orientation, and performance remains a daunting challenge.

92 sensors for in vivo chemical monitoring is a daunting challenge.

93 the 1alpha,25-dihydroxy-VitD(3) constitute a daunting challenge.

94 organization in artificial systems remains a daunting challenge.

95 gement of septic patients has proven to be a daunting challenge.

96 ls from a heterogeneous cell population is a daunting challenge.

97 s, measuring lymphocyte diversity has been a daunting challenge.

98 and maintenance of allograft tolerance is a daunting challenge.

99 cs in finite-size spiking networks remains a daunting challenge.

100 ted independent data points still presents a daunting challenge.

101 y occurring ice-binding proteins (IBPs) is a daunting challenge.

102 ffective treatment of glioblastoma remains a daunting challenge.

103 ntal approaches to address each step of this daunting challenge.

104 in the petrochemical industry and, remains a daunting challenge.

105 zable HEMs and robust design rules remains a daunting challenge.

106 ulation from buccal administration remains a daunting challenge.

107 sitivity of the tumors to therapy) remains a daunting challenge.

108 ing the neuronal basis of individuality is a daunting challenge.

109 chiral selection of molecules presents both daunting challenges and significant opportunities in mat

110 uced by several mechanisms and highlight the daunting challenges associated with preventing or overco

111 st in a series on primary care--outlines the daunting challenges facing primary care today.

112 Integral membrane proteins often present daunting challenges for biophysical characterization, a

113 One of Anthropocene's most daunting challenges for conservation biology is habitat

114 kilometers per year, raising the prospect of daunting challenges for ecosystems, especially in the co

115 ast 5 years offer exciting opportunities and daunting challenges for the development of new therapeut

116 wo different realms has been one of the most daunting challenges in science and technology.

117 tes emerging from such in vitro studies face daunting challenges in the design of proof-of-concept st

118 One of the most daunting challenges is in creating large-area, perfectly

119 elopments in historical context, discuss the daunting challenges that have been overcome, and apprais

120 There are daunting challenges to achieve the targets for child ove

121 ing the multiple co-occurring events present daunting challenges to our scientific community.

122 The perception of color poses daunting challenges, because the light spectrum reaching

123 s, and health services of these nations face daunting challenges, including small and fragile economi

124 1 infection, the immune system already faces daunting challenges.

125 nsin B is an indole diterpenoid that bears a daunting chemical structure featuring a disubstituted ca

126 eatment of neuroepithelial cancers remains a daunting clinical challenge, particularly due to an inab

127 ir regulators are likely involved, but their daunting complexity has hindered progress in dissecting

128 Although the daunting complexity of biological networks affects the d

129 The daunting complexity of ecosystems has led ecologists to

130 When considering the daunting complexity of eukaryotic genomes, some comfort

131 are discovering the unexpected necessity and daunting complexity of our microbial partners.

132 Motivated by this daunting complexity, researchers across disciplines are

133 li translate into perception is a problem of daunting complexity.

134 This circumstance tends to generate daunting computational burdens, and often gives rise to

135 nform such problems but pose an increasingly daunting computational challenge.

136 pedigrees with loops, which continue to pose daunting computational challenges.

137 and families, but such analysis represents a daunting computational task.

138 Envisioning the future of stroke appears daunting considering the milestones already achieved in

139 sease, measuring drug effectiveness, and the daunting cost of clinical trials hampers the development

140 The challenges and controversies of daunting costs, ethics, early diagnosis and health syste

141 d with endodontic lesions are among the most daunting diagnostic and therapeutic challenges faced by

142 tantial progress has already been made, many daunting difficulties remain.

143 But the challenge is daunting due to heterogeneity, feedbacks, and water's sp

144 a multitude of these individual measures is daunting due to the combinatorial explosion of possible

145 This task is daunting due to the complex nature of cellular processes

146 roles of 'non-genetic' inheritance (NGI) is daunting due to the complexity and diversity of epigenet

147 he information seeking that accompanies it a daunting endeavour.

148 r, analyzing the vast output from NGS can be daunting, especially with limited programming skills.

149 the breadth and complexity of NTM-PD remain daunting for both patients and clinicians.

150 In the light of daunting global sustainability challenges such as climat

151 ently and with high efficiencies, has been a daunting goal for synthetic chemists for many years.

152 zing antibody response against HIV remains a daunting goal, data from both natural infection and vacc

153 they infect the mammalian gut in the face of daunting host defenses and an established microbiota rem

154 copeptide structures remains one of the most daunting hurdles in the field of glycoproteomics.

155 This problem is particularly daunting in children with chronic GVHD, whereby the effe

156 However, these tasks are daunting in complex field environments.

157 The challenge of managing change is daunting in the coastal zone where diverse human pressur

158 bered can be not only tedious but also quite daunting, in the case of very large pedigrees.

159 The increasing omics data present a daunting informatics challenge.

160 h pericentrin-mediated disorders is somewhat daunting, insights into the cellular basis of disease ar

161 mate choice will lead an organisation facing daunting internal and external challenges, from its own

162 Equally daunting is that clouds themselves are complex, turbulen

163 Even more daunting is that many of these metastatic deposits silen

164 , mining of the UHPLC-HRAM-MS data is a very daunting, labor-intensive, and expertise-dependent proce

165 ric disorders at a scale necessary to tackle daunting levels of polygenicity.

166 ve and post-preparative chemistry that poses daunting limitations in the context of delivery to any o

167 but solving these equations at scale remains daunting, limited by the computational cost of resolving

168 ective modification of natural proteins is a daunting methodological challenge and a stringent test o

169 tant cousin Plasmodium vivax, resulting in a daunting morbidity and economic burden for countries acr

170 its apparently simple relay function and its daunting multinuclear structure--have been customarily v

171 iation studies (GWAS) has been hampered by a daunting multiple testing problem.

172 nd the biology of SARS-CoV-2 has resulted in daunting numbers of genomic sequences.

173 lack of effective bipolar doping has been a daunting obstacle for achieving the necessary robustness

174 undertake a metabolomics oriented study is a daunting obstacle to investigators new to the field.

175 Daunting obstacles to the development of careers in acad

176 the inconvenience of two spacecraft, but the daunting optics challenges are replaced with a simple de

177 ith plasmonic nanoparticles to satisfy these daunting photocatalytic requirements.

178 The natural product possesses a daunting polycyclic skeleton that contains a furanoindol

179 ntal scientific challenge, but it also faces daunting practical and political challenges.

180 t T cell epitope diversity may not be such a daunting problem for the development of an HIV vaccine.

181 the presence or development of obesity is a daunting problem, it should not be ignored by mental hea

182 and suggesting enzymes to catalyze them is a daunting problem.

183 ession of cancer is a complex and clinically daunting process.

184 , along with the array of choices, present a daunting prospect for biologists, and other researchers

185 Yet the research challenges are daunting; psychiatric syndromes ultimately reflect how t

186 One approach for tackling such a daunting scientific endeavour for complex behaviour-base

187 impacts of ongoing global change across the daunting scope of diversity in Earth's biota and environ

188 lopmental intellectual disability (DID) is a daunting societal problem.

189 of increasingly complex polymers has created daunting, sometimes insurmountable problems for their ch

190 evelop chronic rejection within 10 years - a daunting statistic, particularly for young patients expe

191 Owing to their daunting structural framework and potential as pharmaceu

192 me editing in hPSCs has evolved from being a daunting task a few years ago to a routine procedure in

193 ciation in complex, real-world matrixes is a daunting task because of the low concentration of metals

194 uantification of secreted glycoproteins is a daunting task because of their low abundances compared w

195 allenges for all of these residents can be a daunting task but can be accomplished with proper curric

196 s' that predict adverse drug reactions, is a daunting task by experimental approaches alone.

197 ysis of small populations of cells remains a daunting task due primarily to the insufficient MS signa

198 s of neuromodulatory communication remains a daunting task due to limitations of available monitoring

199 n channel gating from ensemble currents is a daunting task due to limited information in the data.

200 n patterned multi-neuronal spiking remains a daunting task due to the high dimensionality of the acti

201 ng of regulatory variants at these loci is a daunting task due to the juxtaposition of causal and lin

202 Understanding genes and their functions is a daunting task due to the level of complexity in biologic

203 ategy in stabilizing GPCRs, but it remains a daunting task for each GPCR.

204 ducing procedures is a necessary but often a daunting task for emergency medicine providers.

205 ed to form higher-order architectures(1,6)-a daunting task for protein design.

206 es displayed by each transcription factor, a daunting task given the current methodologies for measur

207 lating photons through electrical means is a daunting task given their charge neutrality.

208 is massive sequence information has become a daunting task in biological research.

209 d population of dividing progenitor cells, a daunting task in the developing central nervous system w

210 onal modification (PTM) signatures remains a daunting task in the epigenetics field.

211 But nanoscale height control is a daunting task involving chemical and/or physical process

212 This daunting task is executed by thousands of replication fo

213 advances reveal the cancer gene landscape, a daunting task is to understand how these genes contribut

214 Animals face the daunting task of controlling their limbs using a small s

215 DNA recombinases face the daunting task of locating and pairing up specific sequen

216 Notably, DCs in the gut have the daunting task of orchestrating the balance between immun

217 epartment of Defense (DoD) is faced with the daunting task of possible remediation of numerous soil-C

218 Researchers are then faced with the daunting task of prioritizing these candidate genes for

219 organisms, from bacteria to humans, face the daunting task of replicating, packaging and segregating

220 ntigen processing machinery accomplishes the daunting task of sampling these proteins and cleaving th

221 and searchers are faced with an increasingly daunting task of searching large areas in a short amount

222 to the market, clinicians are faced with the daunting task of sifting through the published literatur

223 etical framework that greatly simplifies the daunting task of solving the highly nonlinear equations

224 l reaction rates in the subsurface remains a daunting task partly because a key parameter for macrosc

225 y which complex nervous systems perform this daunting task remain largely unknown.

226 mical signalling to the whole organism, is a daunting task requiring the marriage of experimental dat

227 ith pooled genetic data, in particular, is a daunting task that raises important statistical issues.

228 However, it is still a daunting task to comprehensively identify and profile se

229 t involved in developing such models it is a daunting task to decide which, if any, coarse-grained mo

230 rbohydrates in lipopolysaccharides make it a daunting task to study the asymmetrical OM structure and

231 lly transmitted diseases (STDs) represents a daunting task, and there have been very few examples of

232 in practice will often find implementation a daunting task, as it tends to require special statistica

233 of most individual amacrine cell types is a daunting task, because few molecular or morphological ma

234 er, analyzing such data is a challenging and daunting task, both because of its sheer volume and beca

235 eavors, the imaging of such "potential" is a daunting task, but one that only molecular imaging--rath

236 lloys out of a vast compositional space is a daunting task, especially for bulk metallic glasses comp

237 h there are six copies of every gene seems a daunting task, however this has recently been reported.

238 entification of such conductive regions is a daunting task, particularly for metal-oxides capable of

239 determinants remains a challenging and often daunting task, requiring extensive experimental screenin

240 Although it is a daunting task, there has never been a better opportunity

241 elective synthesis of furanosides is still a daunting task, unlike the pyranosides, for which several

242 articles that are published each month is a daunting task.

243 into testable hypotheses, however, remains a daunting task.

244 cells from inanimate components seem like a daunting task.

245 cades of research have proven that this is a daunting task.

246 e models of characterizing joint events is a daunting task.

247 molecular mechanisms is required and poses a daunting task.

248 tumor to identify its cellular origins is a daunting task.

249 ll proteins that recognize histone PTMs is a daunting task.

250 to-end approach to machine learning can be a daunting task.

251 olecules with a high degree of ordering is a daunting task.

252 nning approaches, is still a challenging and daunting task.

253 mong highly divergent protein sequences is a daunting task.

254 tation of digital radiologic images can be a daunting task.

255 are removed in eukaryotic cells has proved a daunting task.

256 apid growth, makes access and assimilation a daunting task.

257 onnectivity in the neocortex may seem like a daunting task.

258 rvous system in higher vertebrates this is a daunting task.

259 d with common, complex diseases has become a daunting task.

260 ocesses utilizing molecular oxygen remains a daunting task.

261 system of human subject protections, faces a daunting task.

262 n of enhancers from the human genome seems a daunting task.

263 in energy transfer (EnT) catalysis remains a daunting task.

264 onverting the data into a graphical format a daunting task.

265 tial collection of floorplans, which poses a daunting task.

266 complex vasculature of the kidney remains a daunting task.

267 nt in such small electron-number system is a daunting task.

268 ns in any given life-history trait remains a daunting task.

269 es from high-throughput data still remains a daunting task.

270 ing large lists of iTerm and gene pairs is a daunting task.

271 s essential for precision medicine remains a daunting task.

272 wide studies, quality control becomes a more daunting task.

273 ul information from large data sets can be a daunting task.

274 n function and dysfunction, yet it remains a daunting task.

275 the human naive T cell repertoire remains a daunting task; however, emerging data suggest that homeo

276 utic implications for the successful, albeit daunting, task of targeting these cells.

277 range in solubility or ionization, imposing daunting tasks in areas as different as lipidomics and p

278 ple imputation via chained equations, can be daunting tasks with large numbers of categorical and con

279 and therapeutics from scRNA-seq profiles are daunting tasks.

280 Paediatric EMG, while a daunting technical challenge to some practitioners, rema

281 ut analysis of sulfated N-glycomes remains a daunting technical challenge, because of negatively char

282 y of episodic memory in nonhumans seems less daunting than it did five years ago.

283 Overcoming acquired resistance is a daunting therapeutic challenge, and little is known abou

284 ) type 1 within resting CD4+ T cells poses a daunting therapeutic challenge.

285 f sequence identifiers across databases is a daunting, time-consuming and computationally expensive p

286 are packages that are now available may seem daunting to an experimental biologist.

287 anyone new to this area, however, it can be daunting to decide which techniques or equipment to try.

288 It can be daunting to manually analyze and interpret such large da

289 Analysing geolocator data can be daunting to new and experienced scientists alike.

290 However, it is daunting to render the behavior of organisms intelligibl

291 This rarity makes it daunting to select a CT and MRI protocol for these infan

292 methods for functional neural imaging can be daunting to the nonexpert to navigate.

293 ing and applying genomic knowledge remains a daunting undertaking.

294 D), yet their targeted suppression remains a daunting unmet challenge.

295 Juxtaposition of Red, Ox, and Rel produces a daunting variety of metal electronic excitations, but on

296 The rapid and accurate processing of such daunting volumes of continuously changing data relies on

297 allenges laid out by the Paris Agreement are daunting, we indicate 1.5 degrees C remains possible and

298 c forms using mass spectrometry alone can be daunting, which is why orthogonal techniques, such as io

299 these often lethal biliary tract cancers are daunting, with conventional treatment options being limi

300 s in conjunction with changes in climate are daunting yet critical to address lest we lose continent-