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1 pontaneous dephosphonylation and slow aging (dealkylation).
2 on, 2500-6000-fold, in the rate constant for dealkylation.
3 ted ether PFAS (e.g., NBP1) via hydrolytic O-dealkylation.
4 necessity for phenolic mixture upgrading via dealkylation.
5  through an opening of piperazine ring via N-dealkylation.
6  alkyl adducts from nucleobases by oxidative dealkylation.
7 on which ALKBH3 preferentially functions for dealkylation.
8  EA via its canonical mechanism of oxidative dealkylation.
9 h higher temperature (380-530 degrees C) for dealkylation.
10 um and eliminate the three-carbon unit via N-dealkylation.
11 450 enzymes which catalyze their oxidative N-dealkylation.
12  reports for biotic hydrolysis and oxidative dealkylation (1.7 0.9 and 0.6 0.1, respectively).
13 the quinone ring in the presence of ROS, (2) dealkylation, (3) rearrangement, and (4) deamination.
14 ine O-dealkylase, showed novel and efficient dealkylation activities, including regio- and substrate-
15  peptide hydroxylation and the carbinolamide dealkylation activities.
16 atility, adding to its known decyanation and dealkylation activities.
17 no ether-based substrates to determine the O-dealkylation activity of human, mouse, and rat liver mic
18 developed a fluorescence-based assay for the dealkylation activity of this family of enzymes.
19  and Mn(II) partially restores carbinolamide dealkylation activity to the EDTA-treated enzyme.
20                               CYP2B35 had no dealkylation activity with 7-MFC or 7-EFC.
21  Co(II) produces the greatest restoration of dealkylation activity, 32% relative to a control not tre
22 ition results in the smallest restoration of dealkylation activity, only 3% relative to an untreated
23 al (S)-N-dansyl-Tyr-Val-alpha-hydroxyglycine dealkylation activity.
24                         The pH dependence of dealkylation (aging) in r mouse (Mo) acetylcholinesteras
25                                 The set of O-dealkylation and acetol formation results for wild-type
26  key role of biological dithiols in both the dealkylation and binding of organotin compounds.
27 ment resulted in significant increases in BQ dealkylation and CYP3A6-mediated [3H]testosterone metabo
28 ortance of the studied residues in substrate dealkylation and explained the formation of novel 7-buto
29 varied in terms of catalytic efficiency of O-dealkylation and in their selectivity as substrates for
30 ms and isotope effects associated with the N-dealkylation and N-atom oxidation of substituted N-methy
31 ng 1,4-dihydroquinazolines via a two-step N1 dealkylation and regioselective N3 functionalization pro
32 modifications did not significantly affect N-dealkylation and the formation of the piperidine 3.
33 o linuron, a compound detoxified by a single dealkylation, and a 10-fold increase in tolerance to iso
34 tion, sulfoxidation, epoxidation, heteroatom dealkylation, and carbon-carbon bond formation and cleav
35 ss spectrometry: glucuronidation, sulfation, dealkylation, and oxidation.
36 mediates, which could lead to the observed N-dealkylation, and to the identified formamide and aldehy
37 on, N-hydroxylation, and oxidative N-, and O-dealkylation; as well as reactions catalyzed by peroxida
38 mpounds that could undergo N-dealkylation, O-dealkylation, benzylic hydroxylation, and aromatic hydro
39 isplay lower protein stability and decreased dealkylation but not decyanation activity, suggesting th
40 tion and the calculated energies support the dealkylation by a large energy margin compared to the de
41 esized and characterized as substrates for O-dealkylation by recombinant cytochrome P450 2D6, a major
42 so electrophilic that they underwent in situ dealkylation by the triflate anion (see scheme; Tf = tri
43                This work reports oxidative N-dealkylation/carbonylation of tertiary amines to tertiar
44  highly effective Pd/C-catalyzed oxidative N-dealkylation/carbonylation of various aliphatic as well
45 , eliminative, and hydrolytic), hydrolytic O-dealkylation (especially at the fluorovinyl ether moiety
46 most actinide-mediated bond activations, the dealkylation event mediated by 1 is remarkably general a
47 itterions, and these undergo amine catalyzed dealkylation forming N,N-disubstituted amides.
48 hese OP adducts acquire a negative charge by dealkylation in a process called aging.
49 pH-dependence and solvent isotope effects of dealkylation in diastereomeric adducts of Electric eel (
50 no)benzene were synthesized by the reductive dealkylation in Na/NH(3) of 1,3,5-tris(tert-butylseleno)
51                          Product analysis of dealkylation in P(S)C(S)-soman-inhibited electric eel ac
52                                          The dealkylation in soman-inhibited AChE at pH 5.0 +/- 0.2 a
53                                              Dealkylation in soman-inhibited AChEs is estimated to oc
54                                              Dealkylation in soman-inhibited BChE is consistent with
55 w results support the push-pull mechanism of dealkylation in soman-inhibited cholinesterases proposed
56      The reduction in the rate constants for dealkylation in the E197 mutants is highly pH dependent.
57                                  Oxidative N-dealkylation, in contrast, was subject to large normal (
58 significant proportion of atrazine (63%) via dealkylation, in which deethylation significantly domina
59                                              Dealkylation is found to be the most prevalent reaction
60                   Maximal rate constants for dealkylation (kmax) are 1-6 min-1 for AChE and 2 min-1 f
61 bitor specificity, support a structure-based dealkylation mechanism and suggest a molecular basis for
62 RNA base lesions by using a direct oxidative dealkylation mechanism.
63 th the highest relevance were N-oxidation, N-dealkylation, N-acetylation, and N-succinylation.
64 ibrary of QCA compounds that could undergo N-dealkylation, O-dealkylation, benzylic hydroxylation, an
65 giospecificities of the hydroxylations and O-dealkylations occurring in these two substrates which ar
66 d in Ar at 500 degrees C, demonstrating that dealkylation occurs at this temperature.
67 cetaldehyde, the product expected from the N-dealkylation of 18F-FECNT, or its oxidation product, 18F
68 ines 2a and 2b, and argue strongly for the N-dealkylation of 2a via a carbinolamine intermediate form
69  seen with a slower P450 3A4 reaction, the O-dealkylation of 7-benzyloxyquinoline.
70 hile the V363A mutant mainly catalyzed the O-dealkylation of 7-butoxycoumarin.
71  V363L mutant preferentially catalyzed the O-dealkylation of 7-methoxy- and 7-ethoxycoumarin, and a f
72 ase gene, the product of which catalyses the dealkylation of a sulfonylurea compound, R7402, into its
73 34(327) or E450(443), and H447(440)H+ in the dealkylation of AChE.
74 clic amino groups and accompanied by partial dealkylation of acyclic amino groups.
75 air compensates for the absence of oxidative dealkylation of alkylated nucleobases in budding yeast.
76 n of cyanocobalamin (vitamin B(12)), and the dealkylation of alkylcobalamins (e.g. methylcobalamin; M
77 It catalyzes the glutathione (GSH)-dependent dealkylation of alkylcobalamins and the reductive decyan
78  glyoxylate generation, the base-catalyzed N-dealkylation of alpha-hydroxyhippurate to benzamide and
79                                    In situ N-dealkylation of an intermediate gives the product that f
80 /(14)N versus (13)C/(12)C) isotope plots for dealkylation of atrazine agree with indirect photodegrad
81                PHM catalyzes the O-oxidative dealkylation of BIAA to benzaldoxime and glyoxylate with
82 n of a SET mechanism in the P450-catalyzed N-dealkylation of cyclopropylamines 2a and 2b, and argue s
83                                        The N-dealkylation of DMN had a high intrinsic kinetic deuteri
84       These compounds are active towards the dealkylation of many phosphates.
85       The catalytic turnover numbers for the dealkylation of methylcobalamin and 5'-deoxyadenosylcoba
86 ng C-P lyase (phnJL, an important enzyme for dealkylation of MPn), were only amplifiable from PMEZ DN
87 is protein functions in DNA repair by direct dealkylation of mutagenic O6-alkylguanine.
88     The early proposal that P450-catalyzed N-dealkylation of N,N-dialkylamines proceeds through a sin
89                                     In the N-dealkylation of N-ethyl,N-methylaniline by P450 2B1 (NAD
90  prepared through an unprecedented oxidative dealkylation of readily available phenalene precursors.
91 s the development of a mild method for the N-dealkylation of tertiary amines via photoredox catalysis
92 evirdine and delavirdine, is via oxidative N-dealkylation of the 3-ethyl- or 3-isopropylamino substit
93                                   Subsequent dealkylation of the alpha-hydroxyglycine by another enzy
94  the ascorbate-, O2-, and copper-independent dealkylation of the carbinolamide intermediate.
95 ecule and (b) decrease the rate of oxidative dealkylation of the target compounds.
96 e generated in vitro by hepatic microsomal O-dealkylation of the two methoxy substituents on the benz
97         Metabolic transformation including N-dealkylation of these compounds is also evaluated.
98 37, and the related CYP2B36, we tested the O-dealkylation of three series of related substrates-namel
99 ome P450, CYP76B1, catalyzes rapid oxidative dealkylation of various phenylurea herbicides to yield n
100                      Many enzymes catalyze N-dealkylations of alkylamines, including cytochrome P450
101 Cu(II)-OOH species that performs oxidative N-dealkylation on a dibenzylamino group that is appended t
102 f partially degrading the molecule either by dealkylation or nitro-group reduction have been identifi
103 ways were conducted (visible-light-induced N-dealkylation or sp(3) and sp(2) C-H activation) that lea
104 used to examine whether the P450-catalyzed N-dealkylations proceed through a C(alpha)-H abstraction a
105 ted into the original monomer via a one-step dealkylation process.
106  dramatic inhibition of 7-pentoxyresorufin-O-dealkylation (PROD) was observed when compared to simple
107 ethylsilyl)amide (KHMDS) leads to either the dealkylation product 4 or the deprotonation product, tri
108 ation products were observed by GC-MS, the N-dealkylation product C3F7C(O)NH2 and two carbonyl produc
109   The production of 7-hydroxycoumarin, the O-dealkylation product, by the wild-type enzyme exhibited
110 in is oxidized to an acetol as well as the O-dealkylation product.
111 ne intermediates and thereby to "ordinary" N-dealkylation products including cyclopropanone hydrate.
112 nd complex substrates are shown to undergo N-dealkylation, providing a method with broader functional
113                  Furthermore, differences in dealkylation rates did not correlate with AGT protein af
114 employed to explore various pathways for the dealkylation reaction and the calculated energies suppor
115             Also, they were catalytic in the dealkylation reaction between trimethyl phosphate and ad
116 u(picoloyl)2], formed through an oxidative N-dealkylation reaction followed by further oxidation of t
117       Theoretical calculations revealed that dealkylation reaction is thermodynamically more favorabl
118               The trialkylamines underwent a dealkylation reaction, depending on the degree of steric
119 fer at the enzymic transition states for the dealkylation reaction.
120 aturated alkyl chain from quaternary N via N-dealkylation reaction.
121  to determine the mechanistic details of the dealkylation reaction.
122                                 The reported dealkylation reactions are finely controlled by the anne
123 tails of the reaction pathways, showing that dealkylation reactions are surface-assisted and very dif
124 otope effects of 2-3 were measured for all O-dealkylation reactions examined with wild-type P450 1A2
125  electron transfer (SET) in P450-catalyzed N-dealkylation reactions has been studied using the probe
126     This hybrid system mediates Pd-triggered dealkylation reactions in vitro and inside cells and dis
127 The difference in reactivity, as well as the dealkylation reactions that occur when the reaction of t
128 nic nanorods with the capacity to accelerate dealkylation reactions under near-infrared (NIR) irradia
129 ilic Lewis acid in electrophilic cyclization/dealkylation reactions.
130 ivating agent capable of cyclization but not dealkylation, resulted in the isolation of a postcycliza
131 d an alternate synthesis involving a novel N-dealkylation route.
132 eophiles for electrophilic heterocyclization/dealkylation sequences.
133  can improve yields and reduce the undesired dealkylation side reaction.
134 eophile yet accelerates the rate-determining dealkylation step by reorganizing both the phosphonium c
135  catalytic enantiocontrol of the phosphonium dealkylation step, establishing a new platform for the s
136 ated CYP1 catalytic activity for substrate O-dealkylation suggesting uncoupling.
137 in several cyclic substructures instead of N-dealkylation, suggesting that imines are relevant reacti
138 ffects ( approximately 7) were seen in the N-dealkylations supported by the oxygen surrogate iodosylb
139 etermine which species could yield product O-dealkylation that matched our experimental data.
140 rophenyl phosphate (paraoxon) and subsequent dealkylation, the broad 16.1 ppm resonance increased in
141  possible operation of two hydrolytic, two N-dealkylation, three N-glucuronidation, one N-methylation
142 hloropicrin at high yields, likely by facile dealkylation to release the primary nitro compound.
143                                 For example, dealkylation trends and the overall loss of HMW species
144  (HRP), are generally accepted to catalyze N-dealkylations via 1-electron transfer processes.
145 bably possible for P450s to catalyze amine N-dealkylations via hydrogen atom abstraction when such a
146 nated dibenzyl ether loses formaldehyde upon dealkylation, via an ion-neutral complex of the benzylox
147                                         MeHg dealkylation was also observed in a lesser extent in blo
148 uctase concentration on 7-pentoxyresorufin-O-dealkylation was examined with 2B4-reductase and 1A2-red
149  with F206L and G478S mutants, the rate of O-dealkylation was low with all the compounds.
150                                           BQ dealkylation was measured in the naive rabbit lacrimal g
151 lly protonated at the oxygen, deacylation or dealkylation was observed in the collision-induced disso
152 he fate of the cyclopropyl group lost upon N-dealkylation, we have investigated the oxidation of N-cy
153 rmed by cleavage of the phenolether bond ( O-dealkylation) which primarily formed 3-(methylamino)-1-p
154                                  Enzymatic O-dealkylation yields 7-hydroxycoumarins, which have usefu

 
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