ライフサイエンスコーパス: debilitate

1 r some, fibromyalgia and its symptoms can be debilitating.

2 disorder (PTSD) in adolescents is common and debilitating.

3 ion, powerlessness and guilt were common and debilitating.

4 s ensue, sleep disturbances become even more debilitating.

5 When severe, it causes symptoms that can be debilitating.

6 component of the skin, and SG dysfunction is debilitating(1,2).

7 ltiple arthritogenic alphaviruses that cause debilitating acute and chronic musculoskeletal disease i

8 ding, mosquito-transmitted virus that causes debilitating acute and chronic musculoskeletal disease i

9 metastatic bone disease often present with a debilitating acute phase response as a result of Vgamma9

10 pulmonary disease (COPD) is associated with debilitating adverse effects.

11 poor response to treatment of many patients, debilitating affective disorders (other disorders includ

12 Treatments are lacking for sarcopenia, a debilitating age-related skeletal muscle wasting syndrom

13 ection and lung rehydration in patients with debilitating airway diseases such as COPD.

14 sely, aberrant type 2 inflammation can cause debilitating allergic disease.

15 MCS recipients are debilitated and have some immunological dysfunction.

16 In debilitated and immunocompromised individuals, C. albica

17 ATTR amyloidosis is debilitating and associated with poor life expectancy, e

18 The hallmark of MAYV infection is a highly debilitating and chronic arthralgia.

19 Sepsis remains one of the most debilitating and expensive illnesses, and its prevalence

20 atic dysfunction results in some of the most debilitating and fatal diseases, including pancreatic ca

21 nodosus (Dn) causes footrot in ruminants, a debilitating and highly contagious disease that results

22 Alzheimer's disease is a debilitating and highly heritable neurological condition

23 cerebral palsy often exhibit crouch gait, a debilitating and inefficient walking pattern marked by e

24 This pain can be debilitating and is often inadequately alleviated by pha

25 hemorrhagic telangiectasia (HHT) is a highly debilitating and life-threatening genetic vascular disor

26 complications that potentially are severely debilitating and may even be lethal.

27 tural properties of encoded proteins are non-debilitating and might only change much later.

28 letion of its namesake protein, triggering a debilitating and often fatal form of infantile Parkinson

29 as a unique syndrome which may be severe and debilitating and often mimics malignancy.

30 as a unique syndrome that may be severe and debilitating and often mimics malignancy.

31 Rheumatoid arthritis (RA) is a debilitating and painful inflammatory autoimmune disease

32 Peripheral neuropathy is a debilitating and painful side-effect that can severely i

33 , which closely resembles human asthma, is a debilitating and performance-limiting allergic respirato

34 inum neurotoxin serotype A (BoNT/A) causes a debilitating and potentially fatal illness known as botu

35 asma marginale causes bovine anaplasmosis, a debilitating and potentially fatal tick-borne infection

36 of striatal neurons and the midlife onset of debilitating and progressive chorea, dementia, and psych

37 Mood disorders can be debilitating, and are often correlated with poor general

38 Opioid use disorder is a chronic, debilitating, and costly disorder that has increased in

39 fibropapillomatosis, a globally distributed, debilitating, and fatal tumor disease of endangered mari

40 Bipolar Disorder is costly and debilitating, and many treatments have side effects.

41 tral nervous system (CNS) injuries are often debilitating, and most currently have no cure.

42 Seizures in individuals with AS are common, debilitating, and often drug resistant.

43 symptoms (LUTS) are exceptionally common and debilitating, and they are likely caused or exacerbated

44 owing a spinal deafferentation injury can be debilitating, and this is especially true in primates wh

45 nal cord injury (SCI) is often permanent and debilitating, and usually refractory to treatment with a

46 A 58-year-old woman with debilitating ankylosing spondylitis who was born to cons

47 e delivery of care to patients who have this debilitating arrhythmia.

48 demics of a febrile illness characterized by debilitating arthralgia and arthritis that can endure fo

49 ne RNA virus that causes febrile illness and debilitating arthralgia in humans.

50 a mosquito-borne alphavirus associated with debilitating arthralgia in humans.

51 reemerging global health threat that elicits debilitating arthritis in humans.

52 eemerging global health threat that produces debilitating arthritis in people.

53 d infertility in cattle, and undulant fever, debilitating arthritis, endocarditis, and meningitis in

54 ty of people infected, leading to severe and debilitating arthritis.

55 pathogen that causes both acute and chronic debilitating arthritis.

56 Diencephalic amnesia can be as debilitating as the more commonly known temporal lobe am

57 Atrophy and fat accumulation are debilitating aspects of muscle diseases and are rarely p

58 Thus, treatments that target debilitating aspects of severe NDDs, such as medically-r

59 Clinically, many of the debilitating aspects of the disease are related to a pro

60 ymptomatic patients who are often profoundly debilitated at enrolment.

61 ining program was effective in improving the debilitating attention deficits common to hemispatial ne

62 erythematosus (SLE), a chronic, potentially debilitating autoimmune disease, and they also experienc

63 ges in their shape and orientation can cause debilitating behavioral defects.

64 Retinitis pigmentosa (RP) is a debilitating blinding disease affecting over 1.5 million

65 Osteoporosis is a common and debilitating bone disease that is characterised by low b

66 ify dsRNA as a new treatment target for this debilitating bone pathogenesis.

67 Debilitating cancer-induced muscle wasting, a syndrome k

68 Debilitating cases of tendon pain and degeneration affec

69 piratory papillomatosis (JRRP) is a rare and debilitating childhood disease that presents with recurr

70 Inflammatory bowel disease (IBD) is a debilitating chronic disease with limited treatment opti

71 Depression is a debilitating chronic illness that affects around 350 mil

72 logies linked to oxidative stress, including debilitating chronic non-healing wounds.

73 can experience acute neurovisceral attacks, debilitating chronic symptoms, and long-term complicatio

74 Alzheimer's disease (AD) is a debilitating, chronic neurodegenerative disease.

75 ve treatment has not been developed for this debilitating class of pathologies.

76 tomatous lesions, which leads to diverse and debilitating clinical symptoms.

77 fatal degenerative disorder that results in debilitating cognitive and motor dysfunction.

78 Sleep disorders are among the most debilitating comorbidities of Parkinson's disease (PD) a

79 Diabetic foot ulcers (DFUs) are a debilitating complication of diabetes in which bacterial

80 ntribute to diabetic retinopathy, a visually debilitating complication of diabetes.

81 Hepatic encephalopathy is a frequent and debilitating complication of liver disorders.

82 to deliver notable reductions in weight and debilitating complications are rarely avoided.

83 of better pro-resolving strategies to treat debilitating complications of disorders ranging from inf

84 Feline hip dysplasia (FHD) is a debilitating condition affecting the hip joints of milli

85 Neuropathic pain is a debilitating condition caused by the abnormal processing

86 ominant polycystic kidney disease (ADPKD), a debilitating condition for which there is no cure.

87 derstanding the genetic architecture of this debilitating condition no longer appears to be an imposs

88 although the mechanisms responsible for this debilitating condition remain unclear.

89 Major depressive disorder (MDD) is a debilitating condition that affects over 14 million Amer

90 Peripheral neurotoxicity is a debilitating condition that afflicts up to 90% of patien

91 Endometriosis is a debilitating condition that is categorized by the abnorm

92 tal muscle atrophy is a highly-prevalent and debilitating condition that remains poorly understood at

93 Neuropathic pain can be a debilitating condition with both sensory and affective c

94 Severe emphysema is a debilitating condition with few treatment options.

95 raumatic stress disorder (PTSD) is a common, debilitating condition with limited treatment options.

96 Autism spectrum disorder is a debilitating condition with possible neurodevelopmental

97 known as Chronic Fatigue Syndrome (CFS) is a debilitating condition.

98 improve the treatment of patients with this debilitating condition.

99 cal expertise and that can result in chronic debilitating conditions placing the patient in a vicious

100 Long-term infection can result in debilitating conditions such as pelvic inflammatory dise

101 intractable neuropathic pain is a common and debilitating consequence of neuromyelitis optica spectru

102 Limiting the debilitating consequences of ageing is a major medical c

103 C pulmonary disease (MAC-PD) can be chronic, debilitating, costly, and associated with a high mortali

104 Chronic spontaneous urticaria (CSU) can be debilitating, difficult to treat, and frustrating for pa

105 ard nonthreatening cues is a maladaptive and debilitating dimension of trauma- and anxiety-related di

106 ain.SIGNIFICANCE STATEMENT Chronic pain is a debilitating disease affecting approximately one in thre

107 ntravascular, parasitic flatworms that cause debilitating disease afflicting >200 million people.

108 (WHO) set ambitious goals of control of this debilitating disease and its elimination as a public hea

109 Pulmonary hypertension (PH) is a debilitating disease characterized by remodeling of the

110 Pancreatitis is a debilitating disease of the exocrine pancreas that, unde

111 lopment of new treatment strategies for this debilitating disease of the visual system.

112 candidates.IMPORTANCE Chikungunya fever is a debilitating disease that causes severe pain to the join

113 Obesity is a debilitating disease that has become a global epidemic.

114 hronic fatigue syndrome (ME/CFS) is a highly debilitating disease with heterogeneous constitutional a

115 in light chain-derived (AL) amyloidosis is a debilitating disease without known cure.

116 ) is the most common inherited neuropathy, a debilitating disease without known cure.

117 ebrate hosts, in which EEEV induces a highly debilitating disease, and the outcomes are frequently le

118 scular necrosis of femoral head (AVNFH) is a debilitating disease, which affects the middle aged popu

119 d there are currently no treatments for this debilitating disease.

120 or the discovery of novel therapies for this debilitating disease.

121 y for safely and noninvasively treating this debilitating disease.

122 , and millions have suffered from the highly debilitating disease.

123 e tested now to slow the progression of this debilitating disease.

124 wel diseases (IBDs) are a set of complex and debilitating diseases for which there is no satisfactory

125 polypeptide accumulation) are among the most debilitating diseases our aging societies face.

126 Psychiatric disorders are debilitating diseases, affecting >80 million people worl

127 Dysregulation of human NSTs causes several debilitating diseases, and NSTs are virulence factors fo

128 , and dysregulation of UPR underlies several debilitating diseases.

129 approach for treating otherwise terminal or debilitating diseases.

130 Thyroid eye disease is a debilitating, disfiguring, and potentially blinding peri

131 Mutations in LPL cause a rare but debilitating disorder characterized by excessive plasma

132 Post-traumatic stress disorder (PTSD) is a debilitating disorder that develops in some people follo

133 Depression is a debilitating disorder that often starts manifesting in e

134 Alcohol use disorder (AUD) is a chronic debilitating disorder with limited treatment options and

135 peutic interventions for this widespread and debilitating disorder.

136 nt (AS) of the eye lead to a group of highly debilitating disorders called Anterior Segment Dysgenesi

137 and retinopathy of prematurity (ROP) are two debilitating disorders that develop in preterm infants e

138 Muscular dystrophies are debilitating disorders that result in progressive weakne

139 he paucity of treatments available for these debilitating disorders.

140 iety disorder (GAD) are highly prevalent and debilitating disorders.

141 lity and gait difficulties (PIGDs) represent debilitating disturbances in Parkinson's disease (PD).

142 nts, and facial nerve injury is particularly debilitating due to combined functional impairment and d

143 Issues raised by patients included; the debilitating effect of the disease on quality of life, l

144 f diabetes around the world coupled with its debilitating effects continues to grow.

145 hly malignant childhood brain tumour, impose debilitating effects on the developing child, and highli

146 by traumatic stress eventually give rise to debilitating emotional symptoms, as well as the protecti

147 squito-transmitted flavivirus that can cause debilitating encephalitis.

148 Cushing's disease is a rare debilitating endocrine disorder for which few prospectiv

149 ka virus (ZIKV) was responsible for a recent debilitating epidemic that till date has no cure.

150 tter being only in cases of irreversible and debilitating errors.

151 lepsy is a sleep disorder marked by chronic, debilitating excessive daytime sleepiness and can be ass

152 Half of patients experience debilitating fatigue, which is currently untreatable.

153 em dysfunctions characterized by unexplained debilitating fatigue.

154 hreat processing is central to understanding debilitating fear- and trauma-related disorders such as

155 Dementia is a common, debilitating feature of late Parkinson's disease (PD).

156 Sensory hypersensitivity is a common and debilitating feature of neurodevelopmental disorders suc

157 apeutic potential in acute myeloid leukemia, debilitating fibroses, and obesity-related liver dysfunc

158 distress syndrome, lung adenocarcinoma, and debilitating fibrotic diseases, but the critical transcr

159 ions, high incidence of PE is reported, with debilitating foeto-maternal effects, particularly among

160 This can be debilitating for self-management in adolescence.

161 ating errors across repeated blinks would be debilitating for visual performance.

162 amous cell carcinoma (HNSCC) is a common and debilitating form of cancer characterized by poor patien

163 e therapies to mitigate this progressive and debilitating form of nerve cell death.

164 r Hailey-Hailey disease (HHD), is a rare and debilitating genetic dermatosis characterized by chronic

165 dystrophic epidermolysis bullosa (RDEB) is a debilitating genodermatosis caused by loss-of-function m

166 survival have increased the risk for SNs and debilitating health conditions for survivors yet reduced

167 tive dysfunction (RICD) is a progressive and debilitating health issue facing patients following cran

168 schwannomas (VSs) that cause progressive and debilitating hearing loss, leading to social isolation a

169 Debilitating heart conditions, notably dilated and hyper

170 have been increasingly associated with many debilitating human diseases such as ataxia, Gillespie sy

171 ave been implicated in a host of potentially debilitating human diseases, such as heart disease, type

172 others to combat the private nature of this debilitating illness and bring greater visibility to pat

173 cise correlates to the chronic phase of this debilitating illness and/or this remarkable heterogeneit

174 Bipolar disorder (BD) is a chronic, debilitating illness with a global prevalence of up to 4

175 of schizophrenia is a pivotal phase of this debilitating illness.

176 Psoriatic arthritis (PsA) is a debilitating immune-mediated inflammatory arthritis of u

177 ardiovascular complications, one of the most debilitating in terms of prognosis is heart failure.

178 tophilum causes granulocytic anaplasmosis, a debilitating infection that can be fatal in the immunoco

179 human Guinea worm (GW), causes a painful and debilitating infection.

180 Spasms after spinal cord injury (SCI) are debilitating involuntary muscle contractions that have b

181 lity of methylidene complexes is a generally debilitating issue with all types of catalyst systems.

182 or slow the progression of osteoarthritis, a debilitating joint disease causing cartilage degeneratio

183 tbreaks worldwide in the past decade, causes debilitating joint inflammation and severe pain.

184 acterized by a rapid onset of high fever and debilitating joint pain, though in practice, etiologic c

185 l or functional loss of small intestine, has debilitating long-term consequences for children(1).

186 minish their structural integrity and elicit debilitating low back pain.

187 ic obstructive pulmonary disease (COPD) is a debilitating lung disease associated with cigarette smok

188 ic obstructive pulmonary disease (COPD) is a debilitating lung disease that is currently the third le

189 Farber disease (FD) is a debilitating lysosomal storage disorder characterized by

190 These secondary and debilitating mental health outcomes are important consid

191 Major depressive disorder (MDD) is a debilitating mental illness and a major cause of lost pr

192 Schizophrenia is a debilitating mental illness that affects approximately 1

193 et cognitive impairments in this chronic and debilitating mental illness.

194 Schizophrenia (SZ), one of the most debilitating mental illnesses, is thought to arise, in p

195 ty are complex neurodevelopmental disorders, debilitating millions of people.

196 However, severe cGVHD leads to debilitating morbidity and increased nonrelapse mortalit

197 This debilitating morbidity is attributed to axon demyelinati

198 provide a promising new avenue to lessen the debilitating motor symptoms of HD.

199 DYT1 is a debilitating movement disorder caused by loss-of-functio

200 Holmes tremor is a debilitating movement disorder with limited treatment op

201 litis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating multisystemic disease of unknown etiology,

202 ses, CHIKV also causes long-term painful and debilitating muscle and joint pain, the pathogenesis of

203 of patients with metastatic cancer develop a debilitating muscle-wasting syndrome, known as cachexia,

204 ) is an arthritogenic alphavirus that causes debilitating musculoskeletal disease.

205 ressive Pseudo Rheumatoid Dysplasia (PPRD) a debilitating musculoskeletal disorder.

206 sults in a febrile syndrome characterized by debilitating musculoskeletal pain and arthritis.

207 zeta induces Ca(2+) oscillations in eggs and debilitating mutations in the PLCZ1 gene are associated

208 n was of progressive myoclonus epilepsy with debilitating myoclonic seizures and relatively infrequen

209 tus and a mutation in human STAC3 causes the debilitating Native American myopathy (NAM), but the nat

210 Despite the debilitating nature of 16p11.2 duplications, the underly

211 The debilitating nature of LD is mainly attributed to the ab

212 The progressive debilitating nature of rheumatoid arthritis (RA) combine

213 g-term survivors are left with permanent and debilitating neurocognitive impairments as a result of t

214 minals, is associated with a range of highly debilitating neurodegenerative conditions, including Par

215 Amyotrophic lateral sclerosis (ALS) is debilitating neurodegenerative disease characterized by

216 rials in humans afflicted with this chronic, debilitating neurodegenerative disease.

217 lzheimer's disease (AD) is a progressive and debilitating neurodegenerative disorder and one of the l

218 Parkinson's disease (PD) is a debilitating neurodegenerative disorder caused by the lo

219 Rett syndrome (RTT) is a debilitating neurodevelopmental disorder caused by mutat

220 ide and a frequent cause of hearing loss and debilitating neurologic disease in newborn infants.

221 Treatment-resistant epilepsy is a common and debilitating neurological condition, for which neurosurg

222 Rett syndrome (RS) is a debilitating neurological disorder affecting mostly girl

223 Rett syndrome (RTT) is a debilitating neurological disorder caused by mutations i

224 STATEMENT Traumatic brain injury (TBI) is a debilitating neurological disorder that can seriously im

225 ion of its barriers can result in severe and debilitating neurological disorders.

226 (DM1) is a life-threatening and chronically debilitating neuromuscular disease caused by the expansi

227 age into mitochondria, a condition linked to debilitating neuromuscular disorders in humans.

228 ns by anticancer pharmacotherapy, leading to debilitating neuropathic pain.

229 egies to increase the resiliency of axons in debilitating neuropathies.

230 resistant seizures; are often accompanied by debilitating neuropsychiatric and systemic comorbidities

231 Schizophrenia is a debilitating neuropsychiatric disorder typically diagnos

232 Obsessive-compulsive disorder (OCD) is a debilitating neuropsychiatric disorder with a genetic ri

233 e that confers increased risk for a range of debilitating neuropsychiatric disorders.

234 Schizophrenia is a common, chronic and debilitating neuropsychiatric syndrome affecting tens of

235 rtance as a largely unrecognized pathogen of debilitated older people is increasingly evident.

236 Rare diseases are usually chronically debilitating or even life-threatening with diagnostic an

237 able gynecological disorder characterized by debilitating pain and the establishment of innervated en

238 Schistosomiasis is a debilitating parasitic disease infecting hundreds of mil

239 nflammatory disorder that is associated with debilitating pelvic pain in women.

240 ATA: HO in burns is an uncommon but severely debilitating problem with a poorly understood mechanism

241 Nerve damage can cause chronic, debilitating problems including loss of motor control an

242 in aggregates are a hallmark feature of many debilitating protein deposition diseases such as Alzheim

243 m dermatitis with spontaneous development of debilitating psoriatic arthritis-like joint disease.

244 nia and other psychotic disorders are highly debilitating psychiatric conditions that lack a clear et

245 Posttraumatic stress disorder (PTSD) is a debilitating psychiatric disorder with a lifetime preval

246 Schizophrenia is a debilitating psychiatric disorder with approximately 1%

247 Major depression is a debilitating psychiatric illness that is typically assoc

248 particularly susceptible with many suffering debilitating recurrent (r) infections.

249 Accordingly, chronic visceral pain is debilitating, reduces the quality of life of sufferers,

250 Peripheral nerve injuries can be extremely debilitating, resulting in sensory and motor loss-of-fun

251 ovirus capable of causing a severe and often debilitating rheumatic syndrome in humans.

252 These patients experience debilitating seizures that frequently increase over time

253 igue in cancer patients, the most common and debilitating sequela associated with malignancy.

254 and neurodegeneration constitute clinically debilitating sequelae in demyelinating diseases such as

255 regions and neural signals that initiate the debilitating shakiness of different body parts remain un

256 induced neurotoxicity (CIIN) is a common and debilitating side effect after liver transplantation (LT

257 atment might be an effective therapy for the debilitating side effect of CIPN.

258 py-induced peripheral neuropathy (CIPN) is a debilitating side effect of many cancer treatments.

259 uropathic pain (CIPN) is a common and severe debilitating side effect of many widely used cytostatics

260 ation-induced pulmonary fibrosis (RIPF) is a debilitating side effect of radiation therapy (RT) of se

261 Debilitating side effects of hypoxia manifest within the

262 rs (SEGRAMs) as none of the known GC-induced debilitating side effects were observed in the mouse upo

263 apeutical administration is limited by major debilitating side effects, e.g., skin atrophy, osteoporo

264 ever, the treatment leads to a wide range of debilitating side effects.

265 tion agents, are associated with potentially debilitating side-effects, most notably tardive syndrome

266 b1 gene expression; the former loss caused a debilitating skeletal phenotype, whereas the latter conf

267 dysfunction of REM sleep mechanisms underlie debilitating sleep disorders such as REM sleep behaviour

268 Millions of patients suffer from debilitating spinal cord injury (SCI) without effective

269 skeletal muscle action potentials and causes debilitating stiffness.

270 S) and are twice as likely as men to develop debilitating, stress-associated disorders later in life,

271 Poststroke fatigue is a debilitating symptom and is poorly understood.

272 Mechanical hypersensitivity is a debilitating symptom for millions of chronic pain patien

273 -reactivity to sensory input is a common and debilitating symptom in individuals with autism spectrum

274 nger than 6 weeks, is a highly prevalent and debilitating symptom known to profoundly and negatively

275 nd only to headache, photophobia is the most debilitating symptom reported by people with migraine.

276 to children with nonspecific but potentially debilitating symptoms and to adults who have spent years

277 lems such as neuropathic pain are common and debilitating symptoms in multiple sclerosis (MS), an aut

278 iated with antitumour activity and relief of debilitating symptoms in patients with advanced colorect

279 ry bowel disease (IBD) that may be marked by debilitating symptoms of abdominal pain and obstruction.

280 een available to treat patients with severe, debilitating symptoms of obsessive-compulsive disorder (

281 ressed KIR3DL1 variants protect against more debilitating symptoms of PD, strongly implying a role of

282 reactivity to luminal antigen and results in debilitating symptoms, reduced quality of life, impaired

283 neurological conditions (LTNCs) often cause debilitating symptoms.

284 PFC), but there are few treatments for these debilitating symptoms.

285 effective treatment in controlling otherwise debilitating symptoms.

286 ysfunction are thought to contribute to this debilitating syndrome.

287 linical symptom for many of the world's most debilitating syndromes.

288 disorders, including psoriasis, a common and debilitating T-cell-driven disorder characterized by thi

289 Niche-derived IGF1-dependent Akt activation debilitates the genuine stem-cell state by imposing prim

290 that remove sensation from the hand, can be debilitating, though functional recovery does occur.

291 Oral mucositis (OM), a common debilitating toxicity associated with chemo- and radiati

292 Oral mucositis (OM) remains a common, debilitating toxicity of radiation therapy (RT) for head

293 prove treatment outcomes for this common and debilitating transdiagnostic symptom.

294 patients will survive, but most suffer from debilitating treatment-related complications.

295 Schistosomiasis is a debilitating tropical disease caused by infection with p

296 Debilitated turtles are often rehabilitated in turtle ho

297 Systemic amyloidosis encompasses a debilitating, under-diagnosed but increasingly recognize

298 ut termination of opiate therapy can cause a debilitating withdrawal syndrome in chronic users.

299 E6) gene that cause Christianson syndrome, a debilitating X-linked developmental disorder associated

300 Duchenne muscular dystrophy (DMD) is a debilitating X-linked disorder that is fatal.