ライフサイエンスコーパス: decapentaplegic

1 stabilizing Cubitus interruptus and inducing decapentaplegic.

2 ling by the bone morphogenetic protein (BMP) Decapentaplegic.

3 lium of a second signal, which we suggest is Decapentaplegic.

4 ted downstream of the action of Wingless and Decapentaplegic.

5 the positional cues encoded by wingless and decapentaplegic.

6 ownstream target genes including patched and decapentaplegic.

7 the vgQE acting in concert with Wingless and Decapentaplegic.

8 in the 3-4 intervein region independently of Decapentaplegic.

9 s in the GSTFs Suppressor of Mothers Against Decapentaplegic 2 (SMAD2) and SMAD4 are frequently assoc

10 sion and derepression of SMA mothers against decapentaplegic 2/3 signaling and was confirmed with qua

11 like kinase 1, endoglin, and mothers against decapentaplegic 9.

12 ave implicated glypicans in the signaling of decapentaplegic, a BMP homolog.

13 cytonemes that take up signals such as Dpp (Decapentaplegic, a homolog of the vertebrate bone morpho

14 ous glycosaminoglycan/HSPG-binding morphogen Decapentaplegic-a transforming growth factor beta-like D

15 g) signaling protein and a subset of Wg- and Decapentaplegic-activated genes such as spalt-related, v

16 ile eyeless transcription does not depend on decapentaplegic activity, the expression of eyes absent,

17 ess-regulated genes nubbin, Distal-less, and decapentaplegic and a minimal enhancer from the Ultrabit

18 isc cells mutant for either gene can express decapentaplegic and atonal in response to Hedgehog signa

19 ates dorsal air sac development by producing decapentaplegic and fibroblast growth factor that travel

20 We also show that signaling by Decapentaplegic and Hedgehog normally blocks the posteri

21 ulated by the signalling molecules Wingless, Decapentaplegic and Hedgehog.

22 targets such as argos, ventral veinless and decapentaplegic and leads to formation of extra vein tis

23 The Decapentaplegic and Notch signaling pathways are thought

24 rstood regulatory network with the Hedgehog, Decapentaplegic and Notch signaling pathways to control

25 ts from three signalling pathways: wingless, decapentaplegic and Notch/Suppressor of Hairless.

26 , they are regulated by the secreted protein Decapentaplegic and participate in the positioning of th

27 hat initiation requires both the presence of decapentaplegic and the absence of wingless, which inhib

28 l-1 gene, a C. elegans homolog of Drosophila decapentaplegic and vertebrate BMP genes.

29 while the quadrant enhancer responds to the Decapentaplegic and Wingless morphogen gradients emanati

30 d size modulates the interaction between the Decapentaplegic and Wingless pathways, thereby linking p

31 Signaling by the secreted hedgehog, decapentaplegic and wingless proteins organizes the patt

32 that HS sulfation compensation rescues both Decapentaplegic and Wingless signaling, suggesting a uni

33 dedicated activator alleles fail to repress decapentaplegic and zerknullt in the syncytial blastoder

34 unctions as a dedicated repressor, silencing decapentaplegic and zerknullt while failing to activate

35 twist and snail and repressing genes such as decapentaplegic and zerknullt.

36 molecules, the Smads (small mothers against decapentaplegic), and through Smad-independent pathways.

37 al role: to activate an effector, encoded by decapentaplegic, and an element of negative feedback reg

38 altered expression patterns of the wingless, decapentaplegic, and bric-a-brac genes.

39 molecules, including Hedgehog, Wingless, and Decapentaplegic, and how these define a proximodistal ax

40 nterruptus, branchless, breathless, sprouty, decapentaplegic, and mad are functionally conserved betw

41 e actions of factors downstream of wingless, decapentaplegic, and ras to generate the eve pattern.

42 However, here we show that wingless and decapentaplegic are not required throughout all of proxi

43 e Drosophila eye imaginal disc; hedgehog and decapentaplegic are required for differentiation to init

44 e secreted proteins, Hedgehog, Wingless, and Decapentaplegic, are expressed in the PM, yet they contr

45 rphogens Nodal, fibroblast growth factor and Decapentaplegic as case studies.

46 The role of Decapentaplegic/Bone morphogenetic protein (Dpp/BMP) sig

47 Here, we show that Decapentaplegic/bone morphogenetic protein (Dpp/BMP) sig

48 dependently regulated by hyperplastic discs; decapentaplegic can still be misexpressed in cells mutan

49 el of expression of genes responsive to Dpp (Decapentaplegic) caused by ectopic expression of the typ

50 Wnt and Decapentaplegic cell signaling pathways act synergistica

51 by which a general patterning signal such as Decapentaplegic cooperates reiteratively with tissue-spe

52 activating both Smad (small mothers against decapentaplegic)-dependent and non-Smad pathways.

53 tic proteins (BMPs) composed of two ligands, decapentaplegic (Dpp) a BMP2/4 ortholog and screw (Scw)

54 genetic evidence suggests that a gradient of Decapentaplegic (Dpp) activity determines distinct cell

55 A gradient of Decapentaplegic (Dpp) activity subdivides the dorsal ect

56 orming growth factor beta (TGF-beta) homolog Decapentaplegic (Dpp) acts as a morphogen that forms a l

57 orming Growth Factor-beta superfamily member decapentaplegic (dpp) acts as an extracellular morphogen

58 While Decapentaplegic (Dpp) acts downstream of Ras to maintain

59 ary for the maintenance of the expression of decapentaplegic (dpp) and becomes essential for vein dif

60 ade cytonemes that responded specifically to Decapentaplegic (Dpp) and cells in eye discs made cytone

61 interactions among the genes wingless (wg), decapentaplegic (dpp) and distalless (dll).

62 ied during the pupal stage by Wingless (Wg), Decapentaplegic (Dpp) and Drosophila EGF Receptor (DER)

63 ophila dorsal air sac development depends on Decapentaplegic (Dpp) and Fibroblast growth factor (FGF)

64 Two BMP-like molecules, Decapentaplegic (DPP) and Glass bottom boat, can mediate

65 We have analyzed the function of the Decapentaplegic (Dpp) and Hedgehog (Hh) signaling pathwa

66 is genetically dependent on the presence of Decapentaplegic (Dpp) and Hedgehog receptors.

67 etermination and morphogenesis of the CC are decapentaplegic (dpp) and its antagonist short gastrulat

68 In this paper, we show that Decapentaplegic (DPP) and JNK form a coherent FFL that c

69 Hedgehog (Hh), Decapentaplegic (Dpp) and Notch (N) signaling all contri

70 sterior margin to maintain the expression of decapentaplegic (dpp) and of the proneural gene atonal.

71 uires transport of a heterodimer of the BMPs Decapentaplegic (Dpp) and Screw (Scw) in a protein shutt

72 the bone morphogenetic protein (BMP) family, Decapentaplegic (Dpp) and Screw (Scw), are broadly trans

73 of the Drosophila blastoderm embryo requires Decapentaplegic (Dpp) and Screw (Scw), two BMP family me

74 unction of Tld is to augment the activity of Decapentaplegic (Dpp) and Screw (Scw), two members of th

75 tic signaling between the BMP family members Decapentaplegic (DPP) and Screw (SCW).

76 dient of two TGF(&bgr;) signaling molecules, Decapentaplegic (Dpp) and Screw (Scw).

77 expression of Hh-responsive genes including decapentaplegic (dpp) and wg.

78 is induced in response to the Hedgehog (Hh), Decapentaplegic (Dpp) and Wingless (Wg) morphogens.

79 ved signaling molecules encoded by the genes decapentaplegic (dpp) and wingless (wg) play key roles.

80 cific enhancer elements which are targets of Decapentaplegic (Dpp) and Wingless (Wg) signaling, respe

81 and Wnt signalling from sources of ligands, Decapentaplegic (Dpp) and Wingless (Wg), in dorsal and v

82 res the cooperation of two secreted signals, Decapentaplegic (Dpp) and Wingless (Wg), to form the pro

83 elopment of the Drosophila leg requires both Decapentaplegic (Dpp) and Wingless (Wg), two signals tha

84 liferation through secretion of the mitogens Decapentaplegic (Dpp) and Wingless (Wg).

85 ol of the secreted morphogens Hedgehog (Hh), Decapentaplegic (Dpp) and Wingless (Wg).

86 targets such as the signaling molecule genes decapentaplegic (dpp) and wingless (wg).

87 ila is mediated by the extracellular signals Decapentaplegic (Dpp) and Wingless (Wg).

88 terior compartment to express the morphogens Decapentaplegic (Dpp) and Wingless (Wg).

89 merous studies have shown that it influences Decapentaplegic (Dpp) and Wingless signaling.

90 n the Drosophila leg disc, wingless (wg) and decapentaplegic (dpp) are expressed in a ventral-anterio

91 naling in the posterior crossvein depends on Decapentaplegic (Dpp) at a stage when it is being produc

92 We demonstrate that Wingless (Wg) and Decapentaplegic (Dpp) confer competence for receptor tyr

93 The Drosophila TGF-beta family member decapentaplegic (dpp) contributes to the development of

94 cell clones deprived of the BMP-like ligand Decapentaplegic (DPP) do not die as previously thought b

95 iation is to alleviate repression of eya and decapentaplegic (dpp) expression by the zinc-finger tran

96 nalysis shows that Lsd1 functions to repress decapentaplegic (dpp) expression in adult germaria.

97 During germ band elongation, widespread decapentaplegic (dpp) expression in the dorsal ectoderm

98 Activation of decapentaplegic (dpp) expression in the posterior eye di

99 The decapentaplegic (dpp) gene directs numerous developmenta

100 tion is dependent upon the activation of the decapentaplegic (dpp) gene in a stripe of cells just ant

101 The decapentaplegic (dpp) gene influences many developmental

102 The decapentaplegic (dpp) gene, which encodes a transforming

103 ation of a natural Ubx molecular target, the decapentaplegic (dpp) gene, within the embryonic mesoder

104 The short gastrulation (sog) and decapentaplegic (dpp) genes function antagonistically in

105 tes the patched (ptc), gooseberry (gsb), and decapentaplegic (dpp) genes.

106 Although the Drosophila embryonic Decapentaplegic (Dpp) gradient has served as a model to

107 on has come from a variety of studies of the Decapentaplegic (Dpp) gradient of the Drosophila larval

108 The BMP-related ligand Decapentaplegic (Dpp) has a well-characterized role in p

109 The Drosophila TGFbeta family member Decapentaplegic (DPP) has been proposed to function as a

110 er, NS cleavage was required in vivo for Gbb-Decapentaplegic (Dpp) heterodimer-mediated wing vein pat

111 The gradient of Decapentaplegic (Dpp) in the Drosophila wing has served

112 analyzing the role of the BMP family member decapentaplegic (dpp) in the process of head formation,

113 decapentaplegic (dpp) is a direct target of Ultrabithora

114 F-beta superfamily member and BMP orthologue Decapentaplegic (Dpp) is crucial for multiple developmen

115 In Drosophila, a BMP-related ligand Decapentaplegic (Dpp) is essential for cell fate specifi

116 and the transforming growth factor-beta gene decapentaplegic (dpp) is expressed in an asymmetric fash

117 rphogenetic protein 2/4 (BMP2/4)-like ligand Decapentaplegic (Dpp) is proposed to form a long-range s

118 Here we show that the BMP2/4 homolog decapentaplegic (dpp) is specifically required to mainta

119 hin the cis-regulatory heldout region of the decapentaplegic (dpp) locus in Drosophila melanogaster.

120 The product of the Drosophila decapentaplegic (dpp) locus is a well-characterized memb

121 The Decapentaplegic (DPP) morphogen controls growth in the D

122 Here, we present evidence that the decapentaplegic (Dpp) morphogen distribution in the deve

123 ial for proper interpretation of the zygotic Decapentaplegic (Dpp) morphogen gradient that patterns t

124 oll, and dorsal mutants, but is unaltered in decapentaplegic (dpp) or punt mutants, suggesting that t

125 ignaling molecules such as Wingless (Wg) and Decapentaplegic (Dpp) organize positional information al

126 lio (pum) or for signaling components of the decapentaplegic (dpp) pathway also differentiate.

127 Gradients of decapentaplegic (Dpp) pattern Drosophila wing imaginal d

128 , the secreted signaling molecule encoded by decapentaplegic (dpp) prevents activation of salivary gl

129 to study the extracellular dispersal of the Decapentaplegic (Dpp) protein and show that the Dpp grad

130 sponse to the Drosophila BMP 2/4-like ligand Decapentaplegic (DPP) serves as one of the best-studied

131 rosophila gene zen, which is a target of the Decapentaplegic (Dpp) signaling pathway during cellular

132 tterning through regulation of the conserved Decapentaplegic (Dpp) signaling pathway.

133 rning, and members of both Hedgehog (Hh) and Decapentaplegic (Dpp) signaling pathways, which promote

134 MAD plays an important role in decapentaplegic (DPP) signaling throughout Drosophila de

135 Mothers against dpp (Mad) mediates Decapentaplegic (DPP) signaling throughout Drosophila de

136 mutations in sotv and ttv impair Hh, Wg and Decapentaplegic (Dpp) signaling.

137 to the domain in which the Wingless (WG) and Decapentaplegic (DPP) signals are active.

138 During germ-band extension, Decapentaplegic (Dpp) signals from the dorsal ectoderm t

139 gurken (grk), oskar (osk), bicoid (bcd), and decapentaplegic (dpp) transcripts are normal, with a sli

140 Decapentaplegic (Dpp), a BMP2/4 homologue, has been post

141 We find that Decapentaplegic (Dpp), a Bone Morphogenetic Protein (BMP

142 Decapentaplegic (Dpp), a Drosophila homologue of bone mo

143 Signaling by decapentaplegic (Dpp), a Drosophila member of the transf

144 Decapentaplegic (Dpp), a Drosophila morphogen signaling

145 aster female germline stem cell (GSC) niche, Decapentaplegic (Dpp), a fly transforming growth factor

146 Decapentaplegic (Dpp), a homolog of vertebrate bone morp

147 ryos is specified by an activity gradient of Decapentaplegic (Dpp), a homologue of bone morphogenetic

148 Decapentaplegic (Dpp), a member of the transforming grow

149 of a number of downstream targets, including decapentaplegic (dpp), a TGFbeta homolog.

150 ng is required for the correct expression of decapentaplegic (dpp), a Transforming Growth Factor (bet

151 p vector and generated two unique alleles of decapentaplegic (dpp), a transforming growth factor-beta

152 The first signal, Decapentaplegic (Dpp), acts at long range on undifferent

153 Previous studies have shown that the Dorsal, Decapentaplegic (Dpp), and EGF receptor (Egfr) signaling

154 ing the signaling pathways Hedgehog (Hh) and Decapentaplegic (Dpp), and more recently downstream comp

155 la development, including the hedgehog (hh), decapentaplegic (dpp), and Toll pathways.

156 proteins (BMPs), including the fly homologue Decapentaplegic (DPP), are important regulators of early

157 y role in signaling by the Bmp2/Bmp4 homolog Decapentaplegic (Dpp), by forming a Shn/Smad repression

158 The Drosophila BMP, decapentaplegic (dpp), controls morphogenesis of the ven

159 , which are controlled by the convergence of Decapentaplegic (Dpp), fibroblast growth factor (FGF), W

160 two TGF-beta superfamily members, dawdle and decapentaplegic (dpp), in response to wounding and infec

161 signaling through a Drosophila BMP homolog, Decapentaplegic (Dpp), is disrupted.

162 axis formation, including wingless (wg) and decapentaplegic (dpp), is required for allocating and pa

163 gless (wg) expression at the margins induces decapentaplegic (dpp), optomotor blind (omb), and arista

164 regulates the transcription of target genes decapentaplegic (dpp), patched (ptc) and engrailed (en)

165 by bone morphogenetic protein 4 (BMP-4) and Decapentaplegic (Dpp), respectively.

166 rtebrate bone morphogenetic proteins (BMPs): Decapentaplegic (Dpp), Screw, and Glass bottom boat-60A.

167 Decapentaplegic (Dpp), secreted along the dorsal midline

168 rphogenetic Protein (BMP) signaling pathway, Decapentaplegic (Dpp), specifically in the Class IV mult

169 e Morphogenetic Protein (BMP) ligand family, Decapentaplegic (Dpp), sustains ovarian GSCs by suppress

170 In Drosophila, Decapentaplegic (Dpp), the BMP2/4 homolog, downregulates

171 decapentaplegic (dpp), the Drosophila homolog of human b

172 In Drosophila, we found that decapentaplegic (dpp), the homolog of human bone morphog

173 74, a visceral mesoderm-specific enhancer of decapentaplegic (dpp), to investigate functional dominan

174 ationship with the Drosophila BMP2/4 homolog decapentaplegic (dpp), we have used clonal analysis to d

175 action of two morphogens, Hedgehog (Hh) and Decapentaplegic (Dpp), which act sequentially to organiz

176 umnar epithelia requires the secreted signal Decapentaplegic (DPP), which also acts as a gradient mor

177 o also require the Drosophila BMP2/4 homolog decapentaplegic (dpp), while others do not.

178 rning, we have analyzed a Hedgehog (Hh)- and Decapentaplegic (Dpp)-responsive enhancer of the h gene,

179 pathway through expression of the BMP ligand decapentaplegic (dpp).

180 h overexpression of either unpaired (upd) or decapentaplegic (dpp).

181 nscription and the mobility of the morphogen Decapentaplegic (Dpp).

182 ates MAD and inhibits signal transduction of Decapentaplegic (DPP).

183 ress the secretory factors wingless (wg) and decapentaplegic (dpp).

184 s including Wingless (Wg), Hedgehog (Hh) and Decapentaplegic (Dpp).

185 NK-regulated expression of the BMP4 ortholog Decapentaplegic (Dpp).

186 ticularly those encoded by wingless (wg) and decapentaplegic (dpp).

187 he pattern formation genes wingless (wg) and decapentaplegic (dpp).

188 re embryos null for the TGF-beta-like ligand decapentaplegic (dpp).

189 , which in turn induces the transcription of decapentaplegic (dpp).

190 creted signaling molecules Wingless (Wg) and Decapentaplegic (Dpp).

191 es, where it receives the hub-derived ligand Decapentaplegic (Dpp).

192 d by morphogens such as the TGF-beta homolog Decapentaplegic (DPP).

193 f two secreted morphogens, Wingless (Wg) and Decapentaplegic (Dpp).

194 nctions as an antagonist of the signaling of decapentaplegic (Dpp)/bone morphogenetic protein (BMP) i

195 ssic paradigm-is governed by two morphogens, Decapentaplegic (Dpp, a BMP) and Wingless (Wg, a Wnt).

196 Here, we report that Decapentaplegic (Dpp; a Drosophila BMP family member) pl

197 y expressed signaling molecules Hedgehog and Decapentaplegic drive photoreceptor differentiation in t

198 the homolog of the gene for mothers against decapentaplegic, Drosophila, (MADH4, also known as SMAD4

199 ver-producing the BMP4-like stem cell signal Decapentaplegic efficiently convert into single stem-lik

200 y to operate through the conventional Notch, Decapentaplegic, EGF or FGF transduction pathways, or to

201 gless signaling is also required to activate decapentaplegic expression and to coordinate cell shape

202 rmation is indeed controlled at the level of Decapentaplegic expression but critical steps in regiona

203 motes dorsal closure, in part, by regulating decapentaplegic expression in the dorsal epidermis.

204 ial entry into host cells, ACP competes with Decapentaplegic for binding to glycosaminoglycans/HSPGs

205 noglycan-binding domain of ACP competed with Decapentaplegic for binding to the soluble glycosaminogl

206 ithelium or loss of the BMP signaling ligand decapentaplegic from visceral muscle resulted in phenoty

207 This signal depends upon decapentaplegic function.

208 sophila gene termed MAD (mothers against the decapentaplegic gene).

209 Decapentaplegic has long been thought to be a morphogen

210 e bone morphogenetic protein-mothers against decapentaplegic homolog (Bmp-Smad) pathway is upregulate

211 eptor-mediated activation of Mothers Against Decapentaplegic homolog (SMAD) proteins, although altern

212 amined for EMT and the small mothers against decapentaplegic homolog (Smad), phosphatidylinositol-3-k

213 , and upregulated Similar to Mothers Against Decapentaplegic homolog (Smad)2/3 phosphorylation in und

214 eukin-6 (IL-6) by effects on mothers against decapentaplegic homolog (Smad)4 or signal transducer and

215 ndent phosphorylation (P) of mothers against decapentaplegic homolog (SMAD/P-SMAD)1 and 5, which coul

216 Mothers against decapentaplegic homolog (Smad3) inhibited both CYP7A1 pr

217 hat protein levels of SMAD1 (mothers against decapentaplegic homolog 1) and BAG-4/SODD were strongly

218 that intersects with the BMP-mothers against decapentaplegic homolog 1/5/8 (SMAD1/5/8) pathway.

219 nces nuclear accumulation of mothers against decapentaplegic homolog 2 (Smad2) in embryonic cells.

220 ferentiation and blocking of mothers against decapentaplegic homolog 2 (SMAD2) signaling in MDLC rest

221 ostaining for phosphorylated mothers against decapentaplegic homolog 2/SMAD2, suggesting transforming

222 F-beta by inducing the small mothers against decapentaplegic homolog 3 (SMAD3) nuclear translocation

223 nse elements), NFkappaB, and mothers against decapentaplegic homolog 3 (SMAD3) promoters were created

224 ROM1pos cells with activated Mothers Against Decapentaplegic Homolog 3 (SMAD3) signaling in associati

225 ein expression of CCN1 via a mothers against decapentaplegic homolog 3 (SMAD3)-dependent mechanism.

226 egulation of CD25 in a small mothers against decapentaplegic homolog 3 (Smad3)-dependent mechanism.

227 effects by deactivating the mothers against decapentaplegic homolog 3 (Smad3)/Smad4 transcription co

228 ing galectin-1 (Lgals1), and mothers against decapentaplegic homolog 3 or Smad3, both previously impl

229 r-beta activation and SMAD3 (mothers against decapentaplegic homolog 3) translocation in fibroblasts.

230 LOXL2 transcription through mothers against decapentaplegic homolog 4 (Smad4), whereas two frequentl

231 homologs 2 and 3 and common mothers against decapentaplegic homolog 4, alpha-smooth muscle actin, CD

232 yses show that PRL increased mothers against decapentaplegic homolog 7 (SMAD7) in CD34(+)PRLR(+) myel

233 nd tensin homolog (PTEN) and mothers against decapentaplegic homolog 7 (SMAD7) were subsequently iden

234 in ligase SMURF2, and SMAD7 (mothers against decapentaplegic homolog 7) genes and proteins.

235 s approach identified Smads (mothers against decapentaplegic homolog), the key TGFbeta signaling mole

236 , which negatively regulates mothers against decapentaplegic homolog-3 (Smad3)-initiated production o

237 GFbeta)-dependent Drosophila mothers against decapentaplegic homologs (Smads)/Yes-associated protein

238 n deposition, phosphorylated mothers against decapentaplegic homologs 2 and 3 and common mothers agai

239 (a family of proteins named mothers against decapentaplegic homologs), peroxisome proliferator-activ

240 entified known genes, including hedgehog and decapentaplegic, implicated in these processes.

241 ns of Dally and Dally-like with Wingless and Decapentaplegic in the third-instar Drosophila wing disc

242 nvestigated the role of the TGF-beta homolog decapentaplegic in this pathway.

243 erm-line cells or the overexpression of Dpp (decapentaplegic) in ovarian somatic cells.

244 Ectopic expression of Decapentaplegic induces extra macrochaetes only in cells

245 tive TCF blocks them, and a known Wg target, decapentaplegic, is activated in double mutant clones, s

246 ation of the Drosophila Smad Mothers against Decapentaplegic (Mad) as the readout, we carried out a w

247 worms (SMA) and Drosophilia mothers against decapentaplegic (MAD) gene families.

248 red for dephosphorylation of Mothers against Decapentaplegic (MAD), a Drosophila Smad.

249 stabilizes the SMAD protein Mothers against decapentaplegic (Mad), facilitates its phosphorylation,

250 role for Merlin and Expanded specifically in Decapentaplegic-mediated differentiation events.

251 gnaling molecules and Class III genes encode Decapentaplegic-mediated signaling molecules.

252 ription factor Cubitus interruptus can block decapentaplegic misexpression but not hedgehog misexpres

253 culis and dachshund are greatly reduced in a decapentaplegic mutant background.

254 argets co-regulated by Eyeless and Hedgehog, Decapentaplegic or Notch.

255 By contrast, perturbation of Decapentaplegic or Wingless signaling failed to affect R

256 sing a mutant, non-glycosaminoglycan-binding Decapentaplegic, or the other endogenous glycosaminoglyc

257 We show that Tsg binds both the vertebrate Decapentaplegic orthologue BMP4 and chordin, and that th

258 gnition proteins and antimicrobial peptides, Decapentaplegic overexpression suppressed transcription

259 sphatase that functions in Drosophila in the Decapentaplegic pathway and in mammalian cells in the BM

260 lays antagonistic interactions with the DPP (decapentaplegic) pathway, which regulates branching alon

261 this pathway, phosphorylated mothers against decapentaplegic (pMAD), was reduced.

262 e phosphorylated form of the mothers against decapentaplegic proteins (pSMAD1/5), and transcriptomic

263 sed phosphorylation of small mothers against decapentaplegic proteins.

264 receptor Sax (Saxophone) functions as a Dpp (Decapentaplegic) receptor in Drosophila embryos, but tha

265 hSmad (mothers against decapentaplegic)-related proteins are important messenge

266 Overlapping Mad sites predominate in decapentaplegic response elements, consistent with a hig

267 direct transcriptional targets of the early Decapentaplegic/Screw patterning gradient, to establish

268 in the regulation of tkv gene expression and Decapentaplegic signal transduction that are essential f

269 entiation downstream of the reception of the decapentaplegic signal.

270 gaster JUN N-terminal kinase (DJNK) and DPP (decapentaplegic) signal transduction pathways coordinate

271 We also show that decapentaplegic signaling acts synergistically with and

272 r Eyeless expression and in combination with Decapentaplegic signaling can promote its downregulation

273 wingless and decapentaplegic signaling establishes the proximal-dista

274 saminoglycan synthesis regulate Wingless and Decapentaplegic signaling in Drosophila, and body size i

275 We also provide evidence that decapentaplegic signaling may posttranslationally regula

276 genetic protein (BMP)-son of mothers against decapentaplegic signaling pathway and inhibited by ineff

277 ctions among these QTL with the Hedgehog and Decapentaplegic signaling pathways, which are important

278 rphogenetic protein /sons of mothers against decapentaplegic signaling with no evident adverse effect

279 e existence of redundant mechanisms to block Decapentaplegic signaling.

280 events are independent of hh, wingless, and decapentaplegic signaling.

281 l-family member Escargot and, in subdomains, Decapentaplegic signaling.

282 tkv), which encodes a type I receptor of the Decapentaplegic-signaling pathway.

283 signalling pathways, including Hedgehog and Decapentaplegic signalling.

284 che requiring adhesive stromal cap cells and Decapentaplegic signals.

285 nterior in a wave driven by the Hedgehog and Decapentaplegic signals.

286 ization of activated sons of mothers against decapentaplegic (Smad) and increased the nuclear pool of

287 rphogenetic protein 6 (BMP6)/mothers against decapentaplegic (SMAD) homolog signaling, the main pathw

288 enetic protein (BMP)/sons of mothers against decapentaplegic (SMAD) pathway target genes, a key pathw

289 Small mothers against decapentaplegic (SMAD) proteins are a family of signal t

290 phogenic protein (BMP)/small mothers against decapentaplegic (Smad) signaling cascade is central to t

291 aled that NANOG bound to the mothers against decapentaplegic (SMAD)2 and SMAD3 promoters, in agreemen

292 haSMA, and up-regulated small mother against decapentaplegic (SMAD)7 and CCAAT/enhancer-binding prote

293 Because activation of small mothers against decapentaplegic (Smads) 2/3 is critical for myofibroblas

294 us, organized by the morphogens Wingless and Decapentaplegic, suppress Warts by acting via the atypic

295 ion and its downstream targets, particularly decapentaplegic the Drosophila TGFbeta homolog, suggests

296 ervein cell development, including rhomboid, decapentaplegic, thick veins, and blistered, suggesting

297 headcase, plexus, kohtalo, crumbs, hedgehog, decapentaplegic, thickveins, saxophone, and Mothers agai

298 the bone morphogenetic protein 2/4 homolog, decapentaplegic, to allow progenitors to divide in an un

299 or, acts by activating SMAD (mothers against decapentaplegic) transcription factors, which bind to SM

300 known and novel components of the Hedgehog, Decapentaplegic, Wingless, Epidermal growth factor recep