ライフサイエンスコーパス: decidual

1 Conversely, decidual accumulation of maternal T cells with fetal spe

2 lation allowed for target gene upregulation, decidual activation, and labor entry.

3 n expression of NF-kappaB, TNF, and IL-10 in decidual and myometrial macrophages in C57BL/6J mice.

4 In this study we examined the decidual and peripheral CD8(+) T cell pool for CD45RA, C

5 lpha and IL-6) and chemokines (MIP-1beta) in decidual and placental cells.

6 ecidual tissue and cause a rapid increase in decidual and systemic TNF-alpha levels.

7 ein for IFN-gamma was detected in both total decidual and uNK cell fractions.

8 Total decidual and uNK cells from 8-10 wk and 12-14 wk gestati

9 ggest therefore that uDCs directly fine-tune decidual angiogenesis by providing two critical factors,

10 Depletion of uDCs altered decidual angiogenesis, suggesting that uDCs contribute t

11 Because decidual antigen-presenting cells (APCs) may be importan

12 acental development, and defects in maternal decidual arteries.

13 Decidual artery remodeling is essential for a healthy pr

14 a vital regulatory cascade involving IL-33, decidual B cells and PIBF1 in safeguarding term pregnanc

15 iated stromal cells, and massive breakage of decidual blood vessels, leading to uterine hemorrhage an

16 trual endometrium and the mouse uterus after decidual breakdown, evidence that VEGF has pleiotropic e

17 portant for iTreg cell induction, we studied decidual CD14(+) APCs using immunohistochemistry and flo

18 Human decidual CD14(+) macrophages and CD56(+) NK cells were i

19 We show that decidual CD14(+)DC-SIGN(+) APCs are closely associated w

20 These results suggest that decidual CD14(+)DC-SIGN(+) APCs may play important roles

21 hird trimester decidua and demonstrated that decidual CD4(+) and CD8(+) T cells exhibit a highly diff

22 usly produce IL-12, whereas freshly isolated decidual CD4(+) T cells expressed high levels of activat

23 Understanding how decidual CD8(+) T cell (CD8(+) dT) cytotoxicity is regul

24 Regulation of decidual CD8(+) T cell differentiation may play a crucia

25 Decidual CD8(+) T cells are the main candidates to recog

26 Our data demonstrate that decidual CD8(+) T cells mainly consist of differentiated

27 B mRNA in decidual EM T cells suggests that decidual CD8(+) T cells pursue alternative means of EM c

28 l sections were immunostained for FKBP51 and decidual cell (DC) and interstitial trophoblast (IT) mar

29 Term decidual cell (TDC) monolayers were treated with 10(-8)

30 al regulator of the unique ECM that controls decidual cell architecture and differentiation, and it p

31 Immunostaining localized CSF-2 primarily to decidual cell cytoplasm and cytotrophoblast cell membran

32 nized bacteria in the pregnant uterus led to decidual cell death, tissue disintegration, and resorpti

33 suggests that it acts locally and regulates decidual cell development and the endometrial vasculatur

34 L-6 levels in first trimester leukocyte-free decidual cell incubations, as measured by real time quan

35 HtrA1 and HtrA3 are crucial for trophoblast-decidual cell interaction in the control of trophoblast

36 s tightly regulated and involves trophoblast-decidual cell interaction.

37 erall, the data suggest that CTB EVs enhance decidual cell release of inflammatory cytokines, which w

38 ZIKV-infected decidual cell supernatants increased cytotrophoblasts in

39 Therefore, decidual cell-derived IL-6 may contribute to excess circ

40 membranes (PPROM) and thrombin generation by decidual cell-expressed tissue factor often accompany ab

41 ecidual hemorrhage, which form thrombin from decidual cell-expressed tissue factor.

42 oid receptor (GR), and total and p-ERK1/2 in decidual cells (DCs) and interstitial trophoblasts (IT)

43 ignificantly higher interleukin-6 HSCOREs in decidual cells (DCs) but not in interstitial trophoblast

44 whether adult BMDCs become nonhematopoietic decidual cells and contribute functionally to pregnancy

45 their abilities to attach to and invade both decidual cells and lung epithelial cells.

46 iters, cytomegalovirus replicated in diverse decidual cells and placental trophoblasts and capillarie

47 extrinsic pathway of apoptosis among uterine decidual cells and spongiotrophoblasts.

48 Decidual cells are crucially involved in creating the in

49 al cells, are gestational age dependent, and decidual cells augment ZIKV infection of primary human c

50 Thus, secretion of gal1 by dNKs and other decidual cells contributes to the generation of an immun

51 Decidual cells differentiate from their precursors, the

52 In the mouse, decidual cells differentiate from uterine stromal cells

53 Here, we demonstrate that isolated decidual cells express sFlt-1 mRNA, suggesting that they

54 Also, decidual cells from patients with sPE, which dedifferent

55 her immunohistochemical staining for IL-6 in decidual cells from preeclamptic versus preterm, gestati

56 to morphologically and functionally distinct decidual cells in a unique process known as decidualizat

57 human endometrial stromal cells (HESCs) into decidual cells in response to progesterone, although the

58 es were identified: 1) lymphatic endothelial decidual cells in the chorioamniotic membranes, and 2) n

59 (IL-8) was evaluated in leukocyte-free term decidual cells incubated with estradiol (E2; control) or

60 In human first-trimester decidual cells incubated with estradiol, tumor necrosis

61 Decidual cells incubated with NK cell-derived IFN-gamma

62 chment, de novo synthesis of estrogen by the decidual cells is critical for stromal differentiation.

63 23 strains, however, attached to and invaded decidual cells less than both ST-17 strains.

64 Human decidual cells may act as reservoirs for trimester-depen

65 y, thrombin-enhanced IL-8 expression in term decidual cells may explain how abruption-associated PPRO

66 clusively in luminal epithelial and adjacent decidual cells occurred at implantation sites of hamster

67 The authors' work thus implicates the decidual cells of the mother as the culprit responsible

68 ble induction of GPR64 expression in uterine decidual cells points to its potential physiological sig

69 We found thatFaah(-/-)decidual cells progressively underwent premature senesce

70 icipate in the formation and function of the decidual cells remain poorly understood.

71 Furthermore, we find that uterine decidual cells represent a cell-cell interaction hub wit

72 lantation; however, postimplantation uterine decidual cells showed terminal differentiation and senes

73 a 29-kDa protein and localizes to a band of decidual cells surrounding the trophoblast cell layer on

74 The decidual cells synthesize extracellular matrix (ECM) com

75 e endometrial stromal cells into specialized decidual cells that support the development of the impla

76 nts expression of MMP-1, MMP-3, and MMP-9 in decidual cells to interfere with normal stepwise EVT inv

77 e/paracrine enhancer of sFlt-1 expression by decidual cells to promote pre-eclampsia by interfering w

78 duced colony-stimulating factor-2 (CSF-2) in decidual cells triggers paracrine signaling via its rece

79 C, IFN-gammaR1, and -R2 to vimentin-positive decidual cells versus cytokeratin-positive interstitial

80 e data, we hypothesize that TGF-beta acts on decidual cells via ALK5 to induce expression of other gr

81 Confluent decidual cells were primed for 7 days in either estradio

82 yncytiotrophoblasts, chorionic trophoblasts, decidual cells, and amniotic epithelial cells, as well a

83 ell as innate immune responsiveness of human decidual cells, are gestational age dependent, and decid

84 Previous studies show that preeclamptic decidual cells, but not interstitial EVTs, display highe

85 ctions between the conceptus and surrounding decidual cells, but the involvement of clock genes in th

86 First trimester human decidua is composed of decidual cells, CD56(bright)CD16(-) decidual natural kil

87 e mice also revealed increased cell death in decidual cells, decreased cell proliferation in undiffer

88 es and differentiates into large epithelioid decidual cells, is critical to the establishment of feta

89 rentiation of endometrial stromal cells into decidual cells, is required for implantation.

90 s associated with aberrations in mesometrial decidual cells, mesometrial vascular integrity, and disr

91 In contrast to first trimester decidual cells, thrombin did not affect sFlt-1 levels in

92 Moreover, in first trimester decidual cells, thrombin enhanced sFlt-1 mRNA levels, as

93 d in their abilities to attach to and invade decidual cells, whereas there were no differences with l

94 s, sFlt-1 expression has not been studied in decidual cells, which are the predominant cell type enco

95 to morphologically and functionally distinct decidual cells, which support embryonic growth and survi

96 cells undergo terminal differentiation into decidual cells, which support the proper progression of

97 the cytokine profile produced by the stromal/decidual cells.

98 R-1) was localized to amnion mesenchymal and decidual cells.

99 ile VEGF is upregulated in adjacent maternal decidual cells.

100 icit an endoplasmic stress response in human decidual cells.

101 against excessive VEGFA produced by maternal decidual cells.

102 A and protein expression was constitutive in decidual cells.

103 ation of CB2 in endothelial cells and CB1 in decidual cells.

104 minin constituent of the ECM produced by the decidual cells.

105 production in cultured first-trimester human decidual cells.

106 id not affect sFlt-1 levels in cultured term decidual cells.

107 ctor-alpha affected sFlt-1 expression in the decidual cells.

108 s assessed in leukocyte-free first trimester decidual cells.

109 e into nonhematopoietic prolactin-expressing decidual cells.

110 reased, in human first trimester versus term decidual cells.

111 SA-beta-Gal) staining and gammaH2AX-positive decidual cells.

112 signaling and inhibited mTORC1 signaling in decidual cells.

113 This signature was also observed in human decidual cells.

114 wledge, molecular mechanism whereby maternal decidual chemokines can function in a compartmentalised

115 Strikingly, decidual DCs remained immobile even after being stimulat

116 In this study, we tested the hypothesis that decidual defects are an important determinant of the pla

117 esponses and that disruption impairs uterine decidual development during pregnancy.

118 l functions necessary for propagating normal decidual development during the post-implantation period

119 To further analyze the role of the decidual ECM in modulating maternal-embryo interactions,

120 with peripheral blood EM CD8(+) T cells, the decidual EM CD8(+) T cells display a significantly reduc

121 ased perforin and granzyme B mRNA content in decidual EM CD8(+) T cells in comparison with peripheral

122 gh levels of perforin and granzyme B mRNA in decidual EM T cells suggests that decidual CD8(+) T cell

123 ttle is known regarding the second-trimester decidual environment.

124 Many decidual factors are likely to play a role in regulating

125 orally coincides with PR-A isoform-dependent decidual formation at the time of implantation.

126 oRNAs (miRNAs) involved in the regulation of decidual gene expression in human endometrial stromal ce

127 l proliferation with initiation of aperiodic decidual gene expression; uncoupling of these events may

128 ls of LIF-null animals showed no evidence of decidual giant cell formation even by day 6 of pregnancy

129 in placentas obtained after overt abruption (decidual hemorrhage) with or without PPROM and in contro

130 associated with maternal thrombophilias and decidual hemorrhage, which form thrombin from decidual c

131 infection induces placental inflammation and decidual hyperplasia as well as concomitant increase in

132 Decidual immune cells facilitate embryo implantation and

133 icate crosstalk between EVTs, SpA cells, and decidual immune cells that governs their recruitment to

134 xic decidual NK cells, and 2) the decline of decidual immunotolerant M2-like macrophages.

135 In the decidual implantation site, preeclampsia is accompanied

136 (Slc2a4) on the same diet had an increase in decidual inflammation and vasculopathy occurring togethe

137 During early pregnancy, decidual innate lymphoid cells (dILCs) interact with sur

138 ituent of the integrin receptors targeted by decidual laminins, also inhibited this differentiation p

139 mice is required for proper formation of the decidual layer and remodeling of the uterine vasculature

140 terus, and is essential for formation of the decidual layer of the placenta and remodeling of the ute

141 resulting in reduced spongiotrophoblast and decidual layers in the placenta.

142 ent stages and provide the first evidence of decidual leukocyte involvement in trophoblast-independen

143 ernal arteries and the functional shaping of decidual leukocyte populations.

144 multicolor flow cytometric analyses of human decidual leukocytes detected an elevation in tissue resi

145 immunoglobulin-like receptor B1 receptors on decidual leukocytes is compelling.

146 ; evidence from animal models indicates that decidual leukocytes play a role.

147 oblasts come in direct contact with maternal decidual leukocytes.

148 trophoblast cells and their interaction with decidual leukocytes.

149 , the placenta triggers the development of a decidual lymphatic circulation, which we theorize plays

150 In summary, we demonstrated that decidual M1-like macrophages are associated with spontan

151 n M1-like macrophages in decidual tissue; 3) decidual M2-like macrophages are reduced in preterm preg

152 s an important class A scavenger receptor in decidual macrophage phagocytosis of this microbe.

153 this study, two distinct subsets of CD14(+) decidual macrophages (dMs) are found to be present in fi

154 CD14(+)CD163(+)CD206(+)CD209(+) phenotype of decidual macrophages and produced IL-10 and CCL18 but no

155 his observation was confirmed in situ, where decidual macrophages and T cells are continuously expose

156 f human macrophages, including placental and decidual macrophages and used a novel intrauterine infec

157 Decidual macrophages are implicated in the local inflamm

158 pectedly, inductive perforin-2 expression in decidual macrophages did not occur during milder infecti

159 levels are further enhanced specifically in decidual macrophages during high-dose infections that re

160 ies, regardless of the presence of labor; 4) decidual macrophages express high levels of TNF and IL-1

161 Rgamma) during spontaneous preterm labor; 5) decidual macrophages from women who underwent spontaneou

162 G reduces the expression of TNF and IL-12 in decidual macrophages from women who underwent spontaneou

163 d IL-6 levels may contribute to an excess of decidual macrophages implicated in shallow extravillous

164 In vitro phagocytosis assays with human decidual macrophages incubated with pharmacological inhi

165 to determine the mechanisms whereby uterine decidual macrophages phagocytose this bacterium and test

166 We hypothesized that decidual macrophages undergo a proinflammatory (M1) pola

167 In this study, we show that: 1) decidual macrophages undergo an M1-like polarization dur

168 cterium and tested the hypothesis that human decidual macrophages use class A scavenger receptors to

169 placenta, inductive perforin-2 expression in decidual macrophages was coincident with their polarizat

170 The amount of these cytokines secreted by decidual macrophages was substantially greater than that

171 retion of M1- and M2-associated cytokines in decidual macrophages, and of proinflammatory cytokines (

172 culture supernatants of human placental and decidual macrophages, identifying them as a major source

173 L14 induced chemotaxis of both dNK cells and decidual macrophages, whereas CXCL6 also induced dNK cel

174 but also induces expression of prolactin, a decidual marker gene, in progestin-treated HESCs without

175 erexpression inhibits the induction of major decidual marker genes, including IGFBP1, WNT4 and PRL.

176 zation by regulating the expression of major decidual marker genes.

177 n, as reflected by the impaired induction of decidual markers PRL and IGFBP1.

178 urther showed that Hoxa10 and cyclin D3, two decidual markers, control transcriptional regulation and

179 embrane and laminin 10/11 in the surrounding decidual matrix, suggest that these laminin isoforms inf

180 ion of cytolytic molecules suggests that the decidual microenvironment reduces CD8(+) dT effector res

181 chorioamnionitis could be pivotal in skewing decidual monocyte differentiation to macrophages.

182 ain lymphocyte population in early pregnancy decidual mucosa.

183 Decidual natural killer (dNK) cells play a role in SA re

184 posed of decidual cells, CD56(bright)CD16(-) decidual natural killer (dNK) cells, and macrophages.

185 In contrast, decidual natural killer cell-derived IFN-gamma reverses

186 The interaction of noncytotoxic decidual natural killer cells (dNK) and extravillous tro

187 eceptor 2DS1 (KIR2DS1) expressed by maternal decidual natural killer cells (dNK) and the presence of

188 Cocultures of HLA-G+ EVT with sample matched decidual natural killer cells (dNK), macrophages, and CD

189 tal trophoblasts encounter abundant maternal decidual natural killer cells (dNK).

190 educed fusobacterial-induced fetal death and decidual necrosis without affecting the bacterial coloni

191 uption-associated PPROM, we examined whether decidual neutrophil infiltration complicates abruption-a

192 Collectively, these data show that decidual neutrophil infiltration is not essential for th

193 Abruptions were associated with a marked decidual neutrophil infiltration that peaked after PPROM

194 lain how abruption-associated PPROM promotes decidual neutrophil infiltration.

195 sulted in a 7-fold increase in the number of decidual neutrophils compared with control mice receivin

196 ith peripheral blood neutrophils (PMNs), the decidual neutrophils expressed high levels of neutrophil

197 Uterine decidual NK (dNK) cells and macrophages infiltrate the S

198 In contrast to peripheral blood NK cells, decidual NK (dNK) cells lack cytotoxicity, secrete proan

199 Maternal decidual NK (dNK) cells promote placentation, but how th

200 Retrospective analysis of the decidual NK cell transcriptome revealed a strong senesce

201 e receptor (KIR) genes expressed by maternal decidual NK cells (dNK) and HLA-C genes expressed by fet

202 Decidual NK cells (dNK) are the main lymphocyte populati

203 try, we characterise five main dILC subsets: decidual NK cells (dNK)1-3, ILC3s and proliferating NK c

204 on site of the fetal-maternal interface, and decidual NK cells have been demonstrated to facilitate e

205 immunoglobulin receptors (KIRs) on maternal decidual NK cells is a key factor in the development of

206 hich involves 1) the activation of cytotoxic decidual NK cells, and 2) the decline of decidual immuno

207 es that elicit recruitment and activation of decidual NK cells.

208 substantially greater than that secreted by decidual NK cells.

209 nsition to CD16(-)CD9(+) NK cells resembling decidual NK cells.

210 Decidual NK have distinctive organisation and content of

211 L. monocytogenes infection in primary human decidual organ cultures and in the murine decidua in viv

212 nisms that underlie differentiation into the decidual phenotype remain largely undefined.

213 d)) confirmed a Notch1-dependent hypomorphic decidual phenotype.

214 ncy was often complicated by bleeding at the decidual-placental interface and fetal growth retardatio

215 Decidual PLP-J migrates as a 29-kDa protein and localize

216 ular changes that precede complete P-induced decidual progression.

217 MER39--contribute the enhancer/promoter for decidual prolactin (dPRL), which is dramatically induced

218 ts and also expressed elevated levels of the decidual prolactin Prl8a2, as well as altered levels of

219 okines related to prolactin (PRL), including decidual prolactin-related protein (DPRP).

220 ntation failure was associated with impaired decidual proliferation and differentiation.

221 terine stroma is incapable of undergoing the decidual reaction to support further embryonic developme

222 f the uterus to undergo a hormonally induced decidual reaction was lost.

223 ergo a well-characterized hormonally induced decidual reaction.

224 trophoblastic vesicles, which in turn induce decidual reactions.

225 down-regulation near embryos and attenuates decidual reactions.

226 respo et al. show that human NK cells in the decidual region of the uterus can clear a bacterial infe

227 at of control mice; however, subsequent full decidual response was not observed.

228 x) mouse uterus resulted in the absence of a decidual response, confirming that uterine SRC-2 and -1

229 ombinant human BMP2 can partially rescue the decidual response, suggesting that the observed phenotyp

230 NA knockdown leads to a grossly disorganized decidual response.

231 tation and inhibits P(4)-regulated genes and decidual response.

232 Using in vitro models from decidual samples we demonstrate that hCG inhibits CXCL10

233 Gestational age-matched decidual sections were immunostained for FKBP51 and deci

234 l arteries remains largely restricted to the decidual segment.

235 nabinoid signaling is critical in regulating decidual senescence and parturition timing.

236 man preterm birth, we show here that uterine decidual senescence early in pregnancy via heightened ma

237 ies provide evidence that premature maternal decidual senescence resulting from heightened mTORC1 sig

238 in 53 (p53d/d mice), which exhibit premature decidual senescence that triggers spontaneous and inflam

239 ype mice at midgestation triggered premature decidual senescence utilizing CB1, since administration

240 Decidual senescence with heightened mTORC1 signaling is

241 f spontaneous preterm birth due to premature decidual senescence with increased mTORC1 activity and C

242 Moreover, a similar signature of decidual senescence with increased mTORC1 and COX2 signa

243 vances relevant to intra-amniotic infection, decidual senescence, and breakdown of maternal-fetal tol

244 ntifies a previously unidentified pathway in decidual senescence, which is independent of mTORC1 sign

245 duae, and inhibition of p38 halted premature decidual senescence.

246 Decidual spiral arteriole (SpA) remodeling is essential

247 Uterine response to the initial decidual stimulus of NELF-B UtcKO was similar to that of

248 nonhematopoietic physiologic contribution to decidual stroma, thereby playing important roles in deci

249 CTB EVs increased decidual stromal cell (dESF) transcription and secretion

250 sed to human cytomegalovirus (HCMV)-infected decidual stromal cells (DSC), particularly when DSCs exp

251 riation in attachment to and invasion of the decidual stromal cells and ability to lyse red blood cel

252 a and demonstrated that TAP2 is expressed by decidual stromal cells at the maternal-fetal interface.

253 ri-methyl histone H3 lysine 27 (H3K27me3) in decidual stromal cells dictate both elements of pregnanc

254 blood NK cells with conditioned medium from decidual stromal cells mirrored the effects of TGFbeta1.

255 lls when cultured in conditioned medium from decidual stromal cells supplemented with IL-15 and stem

256 IKV infectiousness/propagation in human term decidual stromal cells versus trophoblasts.

257 l-attracting inflammatory chemokine genes in decidual stromal cells, as evidenced by promoter accrual

258 Decidual stromal cells, when isolated and cultured in vi

259 NK to human cytomegalo virus (HCMV)-infected decidual stromal cells.

260 Decidual T (dT) cells but not peripheral T (pT) cells bo

261 ced by trophoblasts potentially controls the decidual T cell cytokine profile.

262 in part, via its interaction with ILT2, for decidual T cell IL-4 production, known to be crucial for

263 Moreover, decidual T cells proliferated in response to fetal tissu

264 Transcriptional analysis of decidual T cells revealed a unique gene profile characte

265 ow that aPL Abs are specifically targeted to decidual tissue and cause a rapid increase in decidual a

266 the anti-Listeria responses in the maternal decidual tissue are dependent on CSF-1-regulated macroph

267 Decidual tissue development requires a highly regulated

268 to elicit varying host responses in maternal decidual tissue during pregnancy is an important factor

269 t heterozygote females expressed EGFP within decidual tissue in locations identical to endogenous Dpr

270 ttractants and to recruit neutrophils to the decidual tissue in response to Listeria infection.

271 successful implantation via their effects on decidual tissue remodeling, including angiogenesis, and

272 ich was confirmed by immunohistochemistry of decidual tissue sections.

273 steroid biosynthetic enzymes present in the decidual tissue to support de novo synthesis of E.

274 ) are found to be present in first-trimester decidual tissue, CD11c(HI) and CD11c(LO).

275 cells have been shown to be concentrated in decidual tissue, where they are able to suppress fetus-s

276 d on endothelial cells (ECs) of newly formed decidual tissue.

277 ctors that promote neovascularization in the decidual tissue.

278 ular epithelial cells of the first trimester decidual tissue.

279 stem/progenitor cells could be isolated from decidual tissue.

280 number of implantation sites with diminished decidual tissue.

281 re more abundant than M1-like macrophages in decidual tissue; 3) decidual M2-like macrophages are red

282 ase during pregnancy, they remain present in decidual tissues at term.

283 ration of activated iNKT-like cells in human decidual tissues is associated with noninfection-related

284 lement induced by aPL antibodies targeted to decidual tissues, rather than by their anticoagulant eff

285 ulation of Fabp4 and Fatp4 in myometrial and decidual tissues, respectively; this suppression was res

286 ion and macrophage recruitment into maternal decidual tissues.

287 te implantation and trigger the formation of decidual tissues.

288 mature dendritic cells to myometrial and/or decidual tissues.

289 ession levels than minor allele homozygotes; decidual trophoblasts showed strong CXCR3 immunoreactivi

290 Although increasing evidence supports that decidual (uterine) macrophages and regulatory T cells (T

291 Regions of apoptosis at the decidual/uterine interface at e18.5 were observed in con

292 Collectively, these studies identified the decidual uterus as a novel site of E biosynthesis and un

293 during early stages of pregnancy, promoting decidual vascular expansion through VEGF receptor 2 sign

294 the pathologic placental blood vessel lesion decidual vasculopathy (DV) has been shown to predict adv

295 tion resulted in amelioration of HFD-induced decidual vasculopathy independent of offspring genotype

296 of placental abruption, infarction, hypoxia, decidual vasculopathy, or thrombosis of fetal vessels (n

297 ial-like cells to form the avascular primary decidual zone (PDZ) around the implantation chamber (cry

298 arly post-implantation stages in the primary decidual zone (PDZ) surrounding the embryo.

299 forming an avascular zone called the primary decidual zone (PDZ).

300 n, at the mesometrial triangle and secondary decidual zone (SDZ) locations, is critical for successfu