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1 been shown to function as an APRIL-specific decoy.
2 active when the chosen option dominated the decoy.
3 te that neutralizes infection by acting as a decoy.
4 ilar results can be achieved using only 2000 decoys.
5 directly control the diversity of generated decoys.
6 of competitor DNA duplexes, including Egr-1 decoys.
7 igands form more-resilient interactions than decoys.
8 the native state with respect to structural decoys.
9 nked 1st, 1st and 10th among 54 000 possible decoys.
10 duced by standard Rosetta while using 20,000 decoys.
11 protein models and identify good models from decoys.
12 decoy sets consisting of mostly low-quality decoys.
13 sion of Rosetta is able to deliver with 2000 decoys a performance equivalent to that produced by stan
15 nRNP L sequesters miR-574-3p, overcoming its decoy activity and seed sequence-dependent gene silencin
18 thasone, inhibition of miR-433 using a tough decoy altered the period and amplitude of Per2 gene expr
19 targets available in the Directory of Useful Decoys and the performance was evaluated using the area
20 bsolute scores, identify the best model from decoys, and distinguish between good and bad models.
21 of dabigatran, the investigational factor Xa decoy andexanet alfa, and the synthetic small molecule c
22 eral HIV-protease inhibitors can function as decoy antigens to specifically inhibit the binding of an
23 ve flexibility, producing new small-molecule decoy antigens, which neutralize anti-dsDNA antibodies i
25 T cells using a peptide approach; a receptor decoy approach using an analogue of Fcgamma receptor IIB
30 st challenging regions, such as coils, fewer decoys are needed to explore satisfactorily conformation
31 n-native protein structure conformations (or decoys) are often used for designing protein folding sim
32 nding of TFs and highlights the dual role of decoys as attenuators or amplifiers of gene expression n
33 ow-energy conformations (also referred to as decoys) as a way of increasing the likelihood of having
37 jects with distinct patterns of responses to decoys, both of which depended on individuals' risk aver
39 lockade, we engineered a bispecific receptor decoy by attaching the TGF-beta-neutralizing TGFBR2 extr
40 orithm, 3DRobot, to create protein structure decoys by free fragment assembly with enhanced hydrogen-
41 ; however, with the addition of an inferior "decoy" C, females reversed their preferences and chose A
42 effect": introducing an irrelevant option (a decoy) can influence choices among other (relevant) opti
45 t to conventional quantitative PCR assays or decoy cell counts, quantitative urinary PV-Haufen testin
47 erformance of quantitative viremia surpassed decoy cells (area under the curve of 0.95 and 0.79, resp
48 d the diagnostic test performance of urinary decoy cells and urinary SV40T immunochemistry of exfolia
53 phropathy, any urine cytology demonstrating "decoy" cells, and/or significant polyomavirus BK viremia
54 ssion of an anti-inflammatory cytokine and a decoy chemokine receptor can modulate inflammatory proce
55 Here we test whether co-expression of the decoy chemokine receptor M3, that can scavenge inflammat
56 sify models as correct/incorrect; discarding decoys classified as incorrect led to an enrichment in t
57 In bottom-up discovery proteomics, target-decoy competition (TDC) is the most popular method for f
58 OID) that aims to generate highly compelling decoy complexes that are individually matched to availab
61 he learning task further improves the target-decoy database analysis for identifying peptides, which
62 e false discovery rate (FDR) from the target-decoy database search is typically deployed to filter id
64 ncreasing the likelihood of having a diverse decoy dataset that covers a sufficient number of local m
69 ent defense, and RPS4/RRS1 has integrated a "decoy" domain that enables detection of effectors that t
70 red plant immune receptors have incorporated decoy domains that structurally mimic pathogen virulence
71 advantage, of the combination of integrated decoy domains with additional independent effector-NLR i
74 results suggest that the neural basis of the decoy effect could be the context-dependent activation o
76 exhibit a violation of rationality known as "decoy effect": introducing an irrelevant option (a decoy
77 the first group exhibited strong, consistent decoy effects and became more risk averse due to decoy p
80 We found that observed distinct patterns of decoy effects can be explained by a combination of adjus
81 coloration mechanism, the nano-bioreplicated decoys evoked the complete attraction and landing sequen
83 assessed the efficacy of these "fluorescent decoy" (FD) sensors by characterizing active iron transp
85 , in part, to the deployment/secretion of a "decoy flare," for example, anomalous cancer-associated a
86 MutY possesses an exo-site that serves as a decoy for C, and secondly, repulsive forces with a key a
89 tion transgenic mice overexpressing microRNA decoys for either miR-23a or miR-27a, but not miR24-2, s
90 al penton-dodecahedral particles that act as decoys for HD5, thus preventing the inactivation of viru
91 t retrotransposon-derived transcripts act as decoys for miR171, triggering its degradation and thus r
92 protein design strategy to swiftly engineer decoys for neutralizing pathogens that exploit extracell
93 mmatory signaling receptor, sRAGE acts as a "decoy" for RAGE ligands and prevents their interaction w
94 decades, target-decoy approaches (TDAs) and decoy-free approaches (DFAs) have been widely used to es
97 fying one or more biologically-active/native decoys from millions of non-native decoys is one of the
98 igens that induce autoantibodies and exert a decoy function against complement-mediated cytotoxicity.
106 a promising research direction in improving decoy generation for template-free protein structure pre
107 s, we propose that conformation sampling for decoy generation is more naturally framed as a multi-obj
109 prevalence, probably due to the existence of decoy glycan receptors in human gastrointestinal tract l
113 d that, when using the recommended number of decoys, i.e. 20,000, our strategy produces better result
114 aria of transgenic mice expressing a miR-433 decoy in osteoblastic cells (Col3.6 promoter), the ampli
116 tive structure scored better than any of the decoys in 146 cases and was able to rank within the 95th
118 an increase in the proportion of near-native decoys in the ensemble, leading to more accurate predict
119 and negative samples (native and non-native decoys) in a decoy set makes the problem even more compl
120 y active immunoreceptors, ligands, and viral decoys, including challenging cell surface proteins that
121 bition of DLL1/4 with ligand-specific Notch1 decoys increased sprouting of sinusoidal endothelial cel
122 ry simple model that can fully reproduce the decoy influence map and capture its variability in indiv
124 ttribute space and constructed a full map of decoy influence on choices between two otherwise preferr
125 ve/native decoys from millions of non-native decoys is one of the major challenges in computational s
126 MV genome encodes for MHC class I-homologous decoy ligands for inhibitory NK cell receptors to evade
127 lasmid pools encoding more than 30,000 tough decoy miRNA inhibitors (hairpin nucleic acids designed t
129 n this contribution, we demonstrate that the decoy molecule approach enables conversion of a broad ra
134 using various techniques including receptor decoys, multiple co-operative binding sites, and sequent
135 lectively, our findings identify a molecular decoy naturally generated during apoptosis that inhibits
139 noise levels first increase with increasing decoy numbers, before decreasing back to the Poisson lim
141 etric inhibitors often function as molecular decoys of protein-binding partners or nucleic acid targe
143 eport the development of an engineered STAT3 decoy oligodeoxynucleotide (dODN) that is stable in seru
144 Moreover, pretreatment of the cells with a decoy oligonucleotide carrying wild-type p53-response el
145 ucleotide to restore SMN and a complementary decoy oligonucleotide to neutralize its effects in the C
146 ned the kinetic impact of DNA methylation of decoys on the search process of the Egr-1 zinc-finger pr
147 novel mechanism by which ROR may serve as a decoy oncoRNA that blocks binding surfaces, preventing t
148 t with the hypothesis that the presence of a decoy option influences the valuation of other options,
153 ts could be rescued by the treatment of this decoy peptide in both M17 cells overexpressing D620N or
154 we investigated the degree to which TLR TIR decoy peptide modified to include a TAT sequence (Trans-
156 define the binding site, we used a series of decoy peptides derived from the primary amino acid seque
157 The degree of change in risk aversion due to decoy presentation was positively correlated with the or
159 ientific commentary refers to 'Nogo receptor decoy promotes recovery and corticospinal growth in non-
160 and a single intranasal prophylactic dose of decoy protected Syrian hamsters from a subsequent lethal
161 es of various antibodies and ACE2-Fc soluble decoy protein in both assays revealed a high degree of c
162 t) is a recombinant modified human factor Xa decoy protein that has been shown to reverse the inhibit
163 regulation mechanism from nature, which uses decoy protein-binding DNA sites, named DNA sponge, to mo
165 lecule additive during the TMT labeling as a decoy reagent to deplete the excess amount of TMT reagen
167 an ultra-high affinity soluble AXL Fc fusion decoy receptor (sAXL) reduced the growth of a pazopanib-
169 ved ectodomains of osteoprotegerin (OPG) and decoy receptor 3, other two secreted forms of TNFRSF, we
170 operties required the engagement of the IL-1 decoy receptor 8 (IL-1R8) and the activation of AMP-acti
171 ntagonist that outperforms the natural IL-33 decoy receptor and shows anti-inflammatory activities in
172 h neutralizing antibodies or the soluble IFN decoy receptor B18R nor by short hairpin RNA (shRNA) kno
174 e illustrate how GIF serves as a competitive decoy receptor by leveraging binding hotspots underlying
178 In contrast, soluble ST2 appears to act as a decoy receptor for IL-33, blocking myocardial and vascul
181 ernative to the widely used BAFF receptor-Fc decoy receptor for the specific depletion of BAFF in mic
182 pression of CyHV-3 ORF12, encoding a soluble decoy receptor for TNF-alpha, delayed the manifestation
183 ring ischaemia, soluble CD163 functions as a decoy receptor for TWEAK, a secreted pro-inflammatory cy
184 loyed by poxviruses, encoding four viral TNF decoy receptor homologues (vTNFRs) named cytokine respon
185 (IL-1) receptor 1 and high expression of the decoy receptor IL-1 receptor 2 and IL-1 receptor antagon
190 erleukin-1 receptor type 2 (IL1R2) acts as a decoy receptor of exogenous IL-1; however, its intracell
191 NF-kappaB, its ligand RANKL, and the soluble decoy receptor osteoprotegerin are the key regulators of
193 adial glia control this process via the Vegf decoy receptor sFlt1: sflt1 mutants exhibit the venous o
195 pha chain, or treatment with a soluble IL-33 decoy receptor significantly reduced release of inflamma
197 chemokine receptor 2 (ACKR2) is a chemokine decoy receptor that binds and scavenges inflammatory CC
198 treatment of CD patients with etanercept, a decoy receptor that binds soluble TNF, fails to improve
200 1 (mVEGFR1) is an endothelial cell-intrinsic decoy receptor that negatively modulates blood vessel mo
201 ering a second-generation, high-affinity AXL decoy receptor with an apparent affinity of 93 femtomola
202 orm of IL23R mRNA (which then functions as a decoy receptor) and lowers the ability to develop a Th17
203 via antibody binding or VEGF trap (a soluble decoy receptor) is associated with renal-specific thromb
204 f WT mice with soluble IL-33 receptor (IL-33 decoy receptor) markedly reduced CCI-induced hyperalgesi
205 r that protects against ZIKV by serving as a decoy receptor, and plays a protective role in ZIKV-medi
206 n primary ASMC migration and the role of the decoy receptor, Duffy AgR for chemokines (DARC), in this
208 we show that IL-18BP, a high-affinity IL-18 decoy receptor, is frequently upregulated in diverse hum
211 encoding both the IL-33 receptor, ST2L, and decoy receptor, sST2, has been genetically associated wi
212 Lastly, dysregulated IL-33 signaling via the decoy receptor, sST2, predicts C. difficile-associated m
217 Our data indicate sCD48 as a SEB-induced 'decoy' receptor derived from eosinophil and therefore as
221 ode soluble TNFR2 homologs, termed viral TNF decoy receptors (vTNFRs), that display unique specificit
222 eveal a previously underappreciated role for decoy receptors as molecular rheostats in controlling th
223 R signaling and suggest that they can act as decoy receptors for self-antigens that are recognized by
224 ection of cells, or alternatively can act as decoy receptors that bind virions and block virus infect
225 assembly, mimicking the biological effect of decoy receptors that lack the death domain to trigger ap
226 ulated that targeting the type I and type II decoy receptors used by poxvirus to subvert the host inn
228 LR3 and TRAILR4 are generally referred to as decoy receptors, which have been shown to inhibit TRAIL-
232 results show that OPUS-DOSP has an increased decoy recognition capability comparing with those of oth
234 Using directed evolution, we engineered a 'decoy-resistant' IL-18 (DR-18) that maintains signalling
235 in terms of GDT, when using 2000 and 20,000 decoys, respectively, while reducing significantly the n
238 ry rate estimation method, based on a target-decoy search approach, is derived for assigning confiden
240 varied success in handling the challenge of decoy selection despite some issues associated with clus
241 ameworks in achieving robust performance for decoy selection in template-free protein structure predi
243 neural network-based approach named DOcking decoy selection with Voxel-based deep neural nEtwork (DO
248 some issues associated with clustering large decoy sets and decoy sets that do not show much structur
251 -Select shows promising results even for the decoy sets consisting of mostly low-quality decoys.
253 le to generate high-accuracy predictions and decoy sets enriched with near-native loop conformations,
254 ethod was benchmarked with three widely used decoy sets from ab initio folding and comparative modeli
255 lkit, a computational resource including (i) decoy sets generated by different RNA 3D structure predi
256 ociated with clustering large decoy sets and decoy sets that do not show much structural similarity.
262 ing on the three classic effects, we sampled decoy stimuli exhaustively across bidimensional multiatt
265 here has been no systematic benchmark set or decoy structures available for the 3D structure predicti
266 h are much better than unrefined structures; decoy structures generated for 89 NMR structures; and co
267 potentials and used to discriminate between decoy structures produced by RosettaAntibody and predict
268 ng domain (MBD), however, DNA methylation of decoys substantially ( approximately 10-30-fold) acceler
269 etitive" environment including an additional decoy substrate, several qualitatively distinct reaction
271 tationary phases (54 distinct systems and 16 decoy systems) in micellar electrokinetic chromatography
273 s, such as antisense or Transcription Factor Decoys (TFDs), have the potential to circumvent current
274 erexpression of a 5' stem-loop RNA molecular decoy that sequesters LARP6, prevented the ability of IG
275 ions is an ability to act as scaffolds or as decoys that recruit or sequester effector proteins from
276 em by viruses is often mediated by molecular decoys that sequester host proteins pivotal to mounting
281 d with increasing distance from the predator decoy to examine how herbivorous fishes reconcile the co
282 , upregulated during regeneration, acts as a decoy to inhibit PDGF signalling and to prevent FAP over
284 ture imposes generation of a large number of decoys to explore adequately the solution space, limitin
286 uman angiotensin-converting enzyme 2 (hACE2) decoys to neutralize severe acute respiratory syndrome c
288 llected clutches of turtle eggs containing a decoy transmitter enabled us to track the movements of t
289 h during peak mosquito abundance, this "host decoy" trap caught nearly ten times the number of Anophe
290 of mHtt exclude chromatin and form 'sticky' decoy traps that impede target search processes of key r
293 field-tested the InvestEGGator, a 3D-printed decoy turtle egg embedded with a GPS-GSM transmitter (Su
294 on of Notch, using a soluble receptor Notch1 decoy, unexpectedly caused a remarkable increase in live
295 e, we develop a nanodisc incorporated with a decoy virus receptor that inhibits virus infection.
297 that fishes foraging closest to the predator decoy were 40% smaller than those that foraged at furthe
298 ory response and of soluble RAGE acting as a decoy were associated with up-regulation of the DAMP-rel
299 ed in a fragment assembly protocol to sample decoys, which are assessed by a composite scoring functi
300 hydrogen-bonding network and compactness of decoys, which eliminates the possibility of native struc