ライフサイエンスコーパス: dectin-1

1 s) and fungal C-type lectin receptors (e.g., dectin-1).

2 ht determine whether it can be recognized by Dectin-1.

3 f the pattern recognition receptors TLR4 and Dectin-1.

4 oides brasiliensis include TLR-2, TLR-4, and dectin-1.

5 es activation of the fungal pattern receptor dectin-1.

6 inflammatory responses mediated by IL-17 and Dectin-1.

7 n domains of complement receptor 3 (CR3) and dectin-1.

8 surface pathogen recognition receptor called Dectin-1.

9 at-killed C cladosporioides was dependent on Dectin-1.

10 alter the immune response through binding to Dectin-1.

11 rface of the spores and increased binding to Dectin-1.

12 ized by the immune system by their receptor, Dectin-1.

13 on CD18, but not on the beta-glucan receptor dectin-1.

14 hilic inflammation independent of IL-17A and Dectin-1.

15 ucans on their surface and were able to bind Dectin-1.

16 ne system through the innate immune receptor Dectin-1.

17 ich tyrosine kinase 2, and in the absence of Dectin-1.

18 n of yeasts by the host beta-glucan receptor Dectin-1.

19 The role of Dectin-1, a beta-1,3-glucan receptor, critical for funga

20 Dectin-1, a beta-glucan receptor, contributes to host an

21 Lastly, we found Dectin-1, a c-type lectin PRR to be reduced at the prote

22 zonensis infection occurs upon engagement of Dectin-1, a C-type lectin receptor that signals via sple

23 ed by hyphae but not spores and depends upon Dectin-1, a C-type lectin receptor.

24 Detection of C. albicans by Dectin-1, a C-type signaling lectin specific for beta-(1

25 uring P. carinii infection the expression of Dectin-1, a critical receptor for recognition and cleara

26 ward the fungal pathogen, we aimed to target Dectin-1, a pattern-recognition receptor expressed on mo

27 Dectin-1, a receptor for the fungal cell wall carbohydra

28 t and autophagy were offset in vitro through Dectin-1, a receptor that elicits TREM2-like intracellul

29 Phagocytosis via dectin-1 acted as a sensor of microbe size and prevented

30 s TNFSF15 and OX40L, which are essential for dectin-1-activated DC-induced Th9 cell priming.

31 Our results identify dectin-1-activated DCs as a powerful inducer of Th9 cell

32 hat depends on Th9 cells and IL-9 induced by dectin-1-activated DCs in vivo.

33 re, immunization of tumour-bearing mice with dectin-1-activated DCs induces potent antitumour respons

34 Mechanistically, dectin-1 activates Syk, Raf1 and NF-kappaB signalling pa

35 a florid macrophage reaction; however, only dectin-1 activation causes macrophage-mediated demyelina

36 vating TLR2 reduced the injurious effects of dectin-1 activation.

37 rface topology are correlated with increased Dectin-1 adhesion and decreased cell wall elasticity.

38 and binding affinity did not correlate with Dectin-1 agonism, antagonism, or potency.

39 were able to identify a laminarin that is a Dectin-1 agonist and a laminarin that is Dectin-1 antago

40 In vivo a Dectin-1 agonist as adjuvant was sufficient to induce TH

41 DCs become unresponsive to the dectin-1 agonist curdlan and fail to phosphorylate Syk a

42 eir Th9-polarizing capability in response to dectin-1 agonist curdlan.

43 up-regulated after exposure to GM-CSF or the Dectin-1 agonist zymosan.

44 Particulate beta-glucan (a DECTIN-1 agonist) induced mast cell degranulation in mes

45 combinations of TLR agonists with or without Dectin-1 agonist.

46 , there are reports that laminarin is also a Dectin-1 agonist.

47 albicans, live C. albicans, or the specific Dectin-1 agonists curdlan or whole glucan particles.

48 Here, we show that DCs activated by dectin-1 agonists potently promote naive CD4(+) T cells

49 Dectin-1 agonists represent a promising TH1 adjuvant for

50 arins were Dectin-1 antagonists and two were Dectin-1 agonists.

51 mmalian target of rapamycin (mTOR) through a dectin-1-Akt-HIF-1alpha (hypoxia-inducible factor-1alpha

52 Coactivation of neonatal moDCs through Dectin-1 allows TLR-mediated IL-12p70 secretion and TH1

53 GPs are recognized by Dectin-1 and are potent complement activators.

54 ng the CXCR3 ligands, CXCL9 and CXCL10, in a Dectin-1 and Card9- and type I and III interferon signal

55 activating myeloid-specific CTLRs, including Dectin-1 and CLEC-2, and consist of a single tyrosine si

56 y, we examined the relative contributions of Dectin-1 and complement to GP phagocytosis and Ag-specif

57 The GCP formulation of rCpa1 bound soluble Dectin-1 and Dectin-2 and triggered ITAM signaling of co

58 phobin RodA as a virulence factor that masks Dectin-1 and Dectin-2 recognition of conidia, resulting

59 n through activation of the CARD9-associated Dectin-1 and Dectin-2 signal pathways.

60 in ligase CBLB directs polyubiquitination of dectin-1 and dectin-2, two key pattern-recognition recep

61 ntrol of innate immune responses mediated by dectin-1 and dectin-2.

62 he parent G10 strain, which was dependent on Dectin-1 and Dectin-2.

63 SCs through the pattern recognition receptor Dectin-1 and its downstream adaptor protein CARD9.

64 tern recognition receptors for fungi include dectin-1 and mannose receptor, and these mediate phagocy

65 preparations were bound by recombinant human Dectin-1 and mouse Dectin-1, but the affinity varied con

66 DR)+ CD4 and CD8 T cells and negatively with Dectin-1 and NKp30 expression on monocytes and NK cells,

67 to LT-deficient cells restored expression of dectin-1 and PU.1, as well as dectin-1 responsiveness.

68 re, IL-8 secretion was partially mediated by Dectin-1 and required SYK, MAPKs, and the transcription

69 riming requires the beta-1,3-glucan receptor dectin-1 and the noncanonical Raf-1 pathway.

70 e training required the beta-glucan receptor dectin-1 and the noncanonical Raf-1 pathway.

71 The combined loss of dectin-1 and TLR2 completely blocks the proregenerative

72 ity, not necessarily colocalization, between Dectin-1 and TLR2 is required for their synergistic regu

73 Dectin-1 and TLR9 play distinct roles in the recognition

74 Simultaneous coactivation through Dectin-1 and TLRs induced robust secretion of IL-12p70 b

75 targets, we can decouple the receptor pair, Dectin-1 and Toll-like receptor (TLR)2, to opposite side

76 eptors, such as Toll-like receptors 1 and 2, dectin 1, and dendritic cell-specific intercellular adhe

77 recognition receptors, such as pentraxin 3, dectin-1, and Toll-like receptors, leads to complement a

78 activation of C-type lectin receptors (CLR) Dectin-1- and Dectin-2-mediated CARD9 signaling pathway.

79 their downstream kinase SYK, thus inhibiting dectin-1- and dectin-2-mediated innate immune responses.

80 as IL-17A- and Dectin-1-independent, whereas Dectin-1- and IL-17A-dependent pathways were protective

81 a demonstrate that laminarin can be either a Dectin-1 antagonist or agonist, depending on the physico

82 s a Dectin-1 agonist and a laminarin that is Dectin-1 antagonist, both of which are relatively pure p

83 The remaining laminarin was a Dectin-1 antagonist, but when the low m.w. moieties were

84 -beta-glucan that is widely reported to be a Dectin-1 antagonist, however, there are reports that lam

85 h human and mouse cells, two laminarins were Dectin-1 antagonists and two were Dectin-1 agonists.

86 macrophages by fluorescent anti-CR3 and anti-dectin-1 antibodies, respectively, and to stimulate phag

87 es when both an intact complement system and Dectin-1 are present.

88 onses generated via the beta-glucan receptor Dectin-1 are required for lung defense during acute, inv

89 The identification of dectin-1 as a key player in allergy to tropomyosins and

90 relatively short mimetics to bind to CR3 and dectin-1, as compared to the greater degree of polymeriz

91 naling and cytokine production downstream of Dectin-1 because of an increased expression and sustaine

92 osyl lipid adjuvant aqueous formulation) and Dectin-1 (beta-glucan peptide) acted synergistically in

93 Studies using beta-glucans and other Dectin-1 binding components have demonstrated the potent

94 the physical properties, structure, purity, Dectin-1 binding, and biological activity of five differ

95 cans yeast and hyphae is limited to isolated Dectin-1-binding sites.

96 Dectin-1 binds to beta-glucans in fungal cell walls and

97 ficient for the pattern recognition receptor dectin-1 but not Toll-like receptor-2 (TLR2), zymosan-me

98 ound by recombinant human Dectin-1 and mouse Dectin-1, but the affinity varied considerably, and bind

99 Ligation of Dectin-1 by fungal glucans elicits a Th17 response that

100 milar DC profile was obtained by stimulating Dectin-1 (C-type lectin family member) on Rictor(-/-) DC

101 We found that dectin 1 can ligate the lectin galectin 9 in mouse and h

102 s with defects affecting segments of innate (dectin-1, CARD9, IL12RB1) or adaptive immunity (interleu

103 n candidiasis, involves a well-characterized Dectin-1/caspase-associated recruitment domain adaptor 9

104 associated with resolution of inflammation, Dectin-1, CD206 (mannose receptor), and IL-4R.

105 Dectin-1 (Clec7a) is a paradigmatic C-type lectin recept

106 Additionally, CD82 organized Dectin-1 clustering in the phagocytic cup.

107 sults indicate that the beta-glucan receptor Dectin-1 contributes to lung inflammation and immunopath

108 ther, these results define the importance of dectin-1, CR3, and caspase-8, in addition to the canonic

109 hermore, macrophages that were isolated from Dectin-1 (-/-), Dectin-2 (-/-), and CARD9 (-/-) mice sig

110 significantly reduced protective efficacy in Dectin-1 (-/-), Dectin-2 (-/-), and CARD9 (-/-) mice tha

111 3, TLR4, and TLR7), C-type lectin receptors (Dectin-1, Dectin-2, and Mincle), and the cytosolic DNA s

112 ethal dose of C. albicans, and deficiency of dectin-1, dectin-2, or both in Cblb(-/-) mice abrogates

113 nal invasion during systemic infection, with dectin-1 deficiency associating with impaired fungal cle

114 on this response seems to be redundant since dectin-1 deficiency in mice does not affect intestinal i

115 Remarkably, dectin-1 deficiency increased the expansion of regulator

116 Dectin-1 deficiency led to aberrant NET release and NET-

117 ing from different immune defects, including dectin-1 deficiency, CARD9 deficiency, or chronic granul

118 We assessed the responses of dectin-1 deficient macrophages to the intestinal microbi

119 in response towards the intestinal flora in dectin-1 deficient macrophages, during intestinal inflam

120 his microbiota were significantly reduced in dectin-1 deficient macrophages.

121 ic Helicobacter hepaticus induced colitis in dectin-1 deficient mice.

122 liensis infection reinforced the tendency of dectin-1-deficient macrophages to express an M2 phenotyp

123 In Dectin-1-deficient mice, A. versicolor exposure resulted

124 ferentiation and polarization, essential for dectin-1-dependent activation of NK cell-mediated resist

125 or leukotriene B(4) receptor 1 (BLT1) direct dectin-1-dependent binding, ingestion, and cytokine prod

126 In contrast, we observed robust, Dectin-1-dependent IL-22 production by unfractionated lu

127 defense against A. fumigatus is mediated by Dectin-1-dependent IL-22 production.

128 Candida albicans-containing phagosomes in a Dectin-1-dependent manner in GM-CSF-derived bone marrow

129 ific CD4(+) and CD8(+) T cell responses in a dectin-1-dependent manner.

130 icitation of TNF-alpha from macrophages in a Dectin-1-dependent manner.

131 , IFN-gamma, and IL-17A, but not IL-22, in a Dectin-1-dependent manner.

132 lood mononuclear cells and macrophages via a Dectin-1-dependent mechanism.

133 mes containing Candida albicans also require Dectin-1-dependent Syk activation for phagosomal maturat

134 However, whether dectin-1 directs DCs to prime antitumour Th9 cells remai

135 Further, Dectin-1 directs the recruitment of LC3II to phagosomes,

136 t mice deficient in the beta-glucan receptor Dectin-1 displayed increased susceptibility to Aspergill

137 7a-the gene encoding dectin 1-or blockade of dectin 1 downstream signaling was protective.

138 Loss of the dectin-1 downstream effector caspase recruitment domain

139 SHIP-1 colocalized with Dectin-1 during phagocytosis of zymosan in a hemITAM-dep

140 Here, we show that TLR2 and Dectin 1 engagement by zymosan promotes regulatory T-cel

141 Dectin-1 engagement triggers a plethora of activating ev

142 We show that Dectin-1 enhances immune responses triggered predominant

143 In conclusion, dectin-1 exerts an important protective role in pulmonar

144 investigated the role of LTB(4) signaling in dectin-1 expression and responsiveness in macrophages.

145 nses to fungal glucans correlated with lower dectin-1 expression in macrophages from leukotriene (LT)

146 is showed that H. polygyrus bakeri decreases dectin-1 expression on the intestinal DC subsets that dr

147 ecognition receptor dectin-1; restoration of dectin-1 expression recovered innate cytokine production

148 of the transcription factor responsible for dectin-1 expression, PU.1, and PU.1 small interfering RN

149 ll interfering RNA abolished LTB(4)-enhanced dectin-1 expression.

150 hagosomes expressing a signaling incompetent Dectin-1 failed to mature as demonstrated by prolonged D

151 , and precoating the surface of zymosan with Dectin-1:Fc can reduce cytokine production by macrophage

152 All Dectin-1:Fc variants showed specificity of binding to th

153 matory properties by assembling a galectin-3-Dectin-1-FcgammaRIIB receptor complex that activated bet

154 FITC) staining of human neutrophils and anti-Dectin-1-FITC staining of mouse macrophages as well as f

155 lec7a(-/-) mice support the critical role of Dectin-1 for inflammasome activation, restriction of par

156 isting of the carbohydrate binding domain of Dectin-1 fused to the Fc regions of the 4 subtypes of mu

157 Upon disruption of the dectin 1-galectin 9 axis, CD4(+) and CD8(+) T cells, whi

158 The absence of dectin-1 has also impaired the production of T-helper ty

159 urthermore, non-pathogen-derived ligands for dectin 1 have not been characterized.

160 ic cells (DCs) via Dectin-1 using anti-human Dectin-1 (hDectin-1)-HA1 recombinant fusion proteins.

161 In the absence of Dectin-1, heat-killed spores induced a predominantly TH2

162 shown to greatly reduce beta-glucan-induced Dectin-1 immunoreceptor tyrosine-based activating motif

163 row chimeric mice revealed a requirement for dectin-1 in both retina-resident immune cells and bone m

164 3)-glucan, which leads to greater binding by Dectin-1 in both yeast and hyphal forms.

165 Abrogation of dectin-1 in DCs completely abolishes their Th9-polarizin

166 production of IL-22, we examined the role of Dectin-1 in IL-22 production, as well as the role of IL-

167 nd colocalized with the beta-glucan receptor dectin-1 in lipid rafts.

168 rker F4/80 and the description of a role for Dectin-1 in the innate recognition of beta-glucans.

169 that activation of a C-type lectin receptor, dectin-1, in MDSC differentially modulates the function

170 in a CD1d-restricted, MyD88-independent and dectin-1-independent fashion.

171 ncreased after exposure to A. fumigatus in a dectin-1-independent manner.

172 sponse to C. cladosporioides was IL-17A- and Dectin-1-independent, whereas Dectin-1- and IL-17A-depen

173 contrast, clustering the hemi-ITAM receptor Dectin-1 induced signaling that did not require LynA or

174 Restoration of dectin-1-induced Rac1 activation and phagocytosis by res

175 ructure and activity relationships of glucan/Dectin-1 interactions.

176 Dectin 1 is an innate immune receptor crucial for anti-f

177 We found that dectin 1 is highly expressed on macrophages in pancreati

178 hes in the lectin-binding domains of CR3 and Dectin-1 is a promising strategy for the development of

179 Dectin-1 is a receptor for the major fungal cell wall ca

180 Dectin-1 is also present on blood-derived myeloid cells

181 Dectin-1 is an innate pattern recognition receptor essen

182 Our results suggest that Dectin-1 is crucial for macrophage recognition and the m

183 Thus, in mice, dectin-1 is essential for controlling systemic infection

184 Here, we demonstrate that in mice dectin-1 is essential for the control of gastrointestina

185 In the retina, dectin-1 is expressed by microglia and dendritic cells,

186 Thus, although Dectin-1 is necessary for optimal phagocytosis of GPs in

187 In SPPL2a(-/-) bone marrow-derived DCs, Dectin-1 is redistributed to endosomal compartments.

188 Dectin-1 is specifically recruited to the macrophage-hyp

189 cognition receptors, such as TLR4, CD14, and dectin 1, is now known to induce the activation of calci

190 migatus conidia, beta-glucan recognition via Dectin-1 led to the induction of multiple proallergic (M

191 Intraocular injection of the dectin-1 ligand curdlan [a particulate form of beta(1, 3

192 thermore, priming of Xiap(-/-) mice with the dectin-1 ligand curdlan alone resulted in XLP-2-like syn

193 was also observed after stimulation with the Dectin-1 ligand Curdlan.

194 LR engagement as a direct target gene of the Dectin-1 ligand Zymosan.

195 homa 10 (BCL10)-mediated innate responses to dectin-1 ligands but did not affect responses to various

196 administration of IL-17 family cytokines or Dectin-1 ligands promoted regeneration.

197 In response to dectin-1 ligands, Ms4a4a-deficient macrophages showed de

198 Dectin 1 ligation accelerated the progression of PDA in

199 ndrome had reduced TNF-alpha responses after Dectin-1 ligation but in part used a Raf-1-mediated path

200 Dectin-1 ligation is required for gammadeltaT cells to p

201 ut Th17 cell responses due to the absence of Dectin-1 ligation.

202 nificantly decreased TNF-alpha release after Dectin-1 ligation.

203 t polarized surviving M-MDSCs toward CCR7(+) Dectin-1(-)M1 cells, accompanied by IFN-gamma production

204 This prevalent antiinflammatory activity of dectin-1(-/-) macrophages resulted in impaired fungicida

205 y, production of IFN-gamma on stimulation of dectin-1, mannose, and Toll-like receptors with Candida

206 Hence, dectin-1 may be involved in the pathogenesis of IBD.

207 primary tumor growth, but was essential for dectin-1-mediated activation of macrophages and natural

208 responses through a mechanism that required Dectin-1-mediated expression of interleukin-6 (IL-6) by

209 Dectin-1-mediated spleen tyrosine kinase activation is r

210 n-1-sufficient mice, the fungal infection of dectin-1(-/-) mice was more severe and resulted in enhan

211 comparable to zymosan in WT mice, but not in dectin-1(-/-) mice.

212 atitis model using C57BL/6, Mincle(-/-), and Dectin-1(-/-) mice.

213 stitution inflammatory syndrome (IRIS), both Dectin-1:mIgG1 and Dectin-1:mIgG2a Fc reduced hypoxemia

214 vivo challenge model, systemic expression of Dectin-1:mIgG1 Fc significantly reduced ascus burden in

215 ory syndrome (IRIS), both Dectin-1:mIgG1 and Dectin-1:mIgG2a Fc reduced hypoxemia despite minimal eff

216 Dectin-1:mIgG2a Fc was able to reduce the viability of P

217 ogether, these results support a model where Dectin-1 not only controls internalization of beta-1,3-g

218 In dectin-1-null mutant (knock-out) mice, dieback of cortic

219 ligation of Toll-like receptor 2 (TLR2) and Dectin 1 on antigen-presenting cells by zymosan results

220 ted, or "masked," from immune recognition by Dectin-1 on dendritic cells (DCs) and other innate immun

221 vel association between tetraspanin CD82 and Dectin-1 on the plasma membrane of Candida albicans-cont

222 cilitating the recruitment of Syk to the CLR dectin-1 or the adaptor FcRgamma, through its N-SH2 doma

223 on by macrophages from C57BL/6, but not from Dectin-1(-/-) or Dectin-2(-/-) mice.

224 , but not lectin-like oxidized-LDL receptor, Dectin-1, or DC-specific ICAM-3-grabbing nonintegrin fav

225 complement receptor 3 (CD11b/CD18), but not Dectin-1, or ROS.

226 whereas deletion of Clec7a-the gene encoding dectin 1-or blockade of dectin 1 downstream signaling wa

227 ive to Histoplasma infection than wild-type, Dectin-1-/-, or interleukin 1 receptor-deficient (IL-1R-

228 ticles (WGP; a ligand to engage and activate dectin-1, oral treatment in vivo) significantly decrease

229 Innate immune signaling through the Dectin-1 pathway was assessed in both PBMCs from patient

230 trafficking, is recruited directly by LC3 to Dectin-1 phagosomes.

231 nd that both complement receptor 3 (CR3) and dectin-1 play a crucial role in coordinating beta-glucan

232 7-producing gammadeltaT cells or deletion of Dectin-1 prevented development of regenerative phenotype

233 In addition, LTB(4) effects on dectin-1, PU.1, and cytokine production were blunted in

234 ubclasses, showing that vaccine targeting to Dectin-1 receptor can benefit from augmentation and immu

235 jor surface glycoprotein also down regulated Dectin-1 receptor messenger ribonucleic acid (mRNA) expr

236 ritic cells (DCs) following detection by the Dectin-1 receptor, but the effects of beta-glucan-induce

237 Focusing on CLEC7A, which encodes for the dectin-1 receptor, flow analysis showed that H. polygyru

238 pathways downstream of both the TCR and the Dectin-1 receptor.

239 lucans and was mediated by activation of the Dectin-1 receptor.

240 mulated cells were mTOR-independent and used Dectin-1 receptor.

241 This effect was dependent on the dectin-1 receptor.

242 umigatus and C. albicans phagosomes requires Dectin-1 recognition.

243 The receptor protein Dectin-1 recognizes structures found on cancerous cells,

244 In addition, Dectin-1 regulates TLR9-dependent gene expression.

245 expression of dectin-1 and PU.1, as well as dectin-1 responsiveness.

246 pression of the pattern recognition receptor dectin-1; restoration of dectin-1 expression recovered i

247 Ligand binding to Dectin-1 resulted in the following: 1) activation of Src

248 ure of cell wall glucans, and recognition by Dectin-1 results in increased phagocytosis by lung macro

249 ailed to mature as demonstrated by prolonged Dectin-1 retention, presence of Rab5B, failure to acquir

250 ased cytokine production after inhibition of dectin 1 revealed that this receptor plays a major role

251 In addition, AFM tips functionalized with Dectin-1 revealed that the forces of binding of Dectin-1

252 Mutations in dectin-1 (rs7309123) and DC-SIGN (rs11465384 and rs72486

253 s employed to show binding and activation of Dectin-1 signal transduction pathway by the beta-glucan-

254 These data suggest that targeting dectin 1 signaling is an attractive strategy for develop

255 SOCS1 did not modulate Dectin-1 signaling but affected TLR signaling, leading t

256 e that CD82 organizes the proper assembly of Dectin-1 signaling machinery in response to C. albicans.

257 including the TCR pathway in T cells and the Dectin-1 signaling pathway in phagocytes.

258 be, Tang et al. (2015) show that suppressing Dectin-1 signaling protects mice from experimental colit

259 further dependent on pathways downstream of Dectin-1 signaling, notably reactive oxygen species (ROS

260 Deletion of CD82 modulates Dectin-1 signaling, resulting in a reduction of Src and

261 ng to define a more precise picture of early Dectin-1 signaling, we explored the interactome of the i

262 erent from other Syk-coupled CLRs, including Dectin-1, signaling cascade through DC-ASGPR did not tri

263 Dectin-1 signalling in dendritic cells (DCs) has an impo

264 that SCIMP is strongly phosphorylated after Dectin-1 stimulation and that it participates in signal

265 Notably, dectin-1 stimulation of DCs upregulates TNFSF15 and OX40

266 ular pathways triggered by combined TLR plus Dectin-1 stimulation was determined by using pharmacolog

267 aling downstream of Toll-like receptor 2 and dectin-1 stimulation.

268 This fact motivated us to use dectin-1-sufficient and -deficient mice to investigate t

269 Compared with dectin-1-sufficient mice, the fungal infection of dectin

270 ainst live C. albicans that was dependent on Dectin-1, Syk, and NADPH oxidase.

271 s increased oxidative burst was dependent on Dectin-1, Syk, PI3K, phosphoinositide-dependent protein

272 well as beta-glucan exposure, activated the Dectin-1-SYK-epidermal growth factor receptor-AKT/extrac

273 Our studies link Dectin-1/Syk kinase signaling with autophagy-dependent m

274 Additionally, our data reveal that the dectin-1/Syk pathway is redundant and that TLR2 has an i

275 Thus, we reported that activation of the Dectin-1/Syk/ROS/NLRP3 pathway during L. amazonensis pha

276 tion between IgG1 titer and SNP rs3901533 of dectin-1, the beta-glucan receptor.

277 Dectin-1, the innate immune receptor that recognizes bet

278 We adapted the pattern-recognition receptor Dectin-1 to activate T cells via chimeric CD28 and CD3-z

279 tin-1 revealed that the forces of binding of Dectin-1 to all of the strains were similar, but the fre

280 or (TLR) 2/1 heterodimer in cooperation with Dectin-1 to initiate signaling by the downstream phospho

281 of acidification results in retention of GFP-Dectin-1 to phagosome membranes highlighting the require

282 or Syk results in prolonged retention of GFP-Dectin-1 to the phagosome signifying a link between Syk

283 Dectin-1, Toll-like receptor 2, and Toll-like receptor 4

284 1 signaling as an unrecognized controller of dectin-1 transcription via GM-CSF and PU.1 that is requi

285 We show that GFP-Dectin-1 translocates to the fungal phagosome, but its s

286 via a new, NF-kappaB-independent pathway in Dectin-1-triggered murine BMMs and influences TLR cross

287 rates that recognition of beta-1,3 glucan by Dectin-1 triggers TLR9 trafficking to beta-1,3 glucan-co

288 Following beta-1,3-glucan recognition, GFP-Dectin-1 undergoes tyrosine phosphorylation by Src kinas

289 1 was delivered to dendritic cells (DCs) via Dectin-1 using anti-human Dectin-1 (hDectin-1)-HA1 recom

290 g required Syk tyrosine kinase activity, but dectin-1 was dispensable for both of them.

291 A macrophage cell line expressing Dectin-1 was employed to show binding and activation of

292 risingly, however, following oral infection, dectin-1 was not required for the control of mucosal col

293 Laminarin, a beta-glucan ligand of Dectin-1, was incorporated into the original beta-mannan

294 hese receptors, ligands specific for TLR2 or dectin-1 were microinjected, alone or in combination, in

295 onidia involves integrin CD11b/CD18 (and not dectin-1), which triggers a PI3K-dependent nonoxidative

296 r molecules like the C-type signaling lectin Dectin-1, which is found on macrophages, neutrophils, an

297 two pathogen recognition receptors, TLR2 and dectin-1, which recognize the same microbial stimulus (z

298 regulated expression of CCL20 and ligands of Dectin-1, which was associated with recruitment and acti

299 trigger innate receptors (e.g., TLRs, Rig-I, Dectin-1) within APCs, with the consequential induction

300 Studies with dectin-1(-/-)/WT reciprocal bone marrow chimeric mice re