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1                                    In cells, dedicated AAA+ ATPases deposit hexameric, ring-shaped he
2 en performed using (31)P-NMR, which requires dedicated access to a specialized NMR spectrometer.
3 nthase, a dehydratase, a decarboxylase and a dedicated acyl carrier protein.
4 ately 80% of critical care organizations had dedicated advanced practice providers that staffed some
5 ssessment and describes the development of a dedicated algorithm.
6 rther investigations elucidating the role of dedicated AMPK subunits in the modulation of gene expres
7 quencing, synthetic library generation and a dedicated analysis pipeline.
8 eveloped smartwatch, and augmentation with a dedicated analytical framework (for redox peak extractio
9        Cellular homeostasis relies on having dedicated and coordinated responses to a variety of stre
10 ique material aspects and structural designs dedicated, and finally, a discussion of the newly enable
11                                 A refocused, dedicated, and intensive biomedical research program is
12 nd other mobile genetic elements and rely on dedicated antiviral defense systems, such as restriction
13 e for, and the output and shortcomings of, a dedicated AS rotation.
14                                        A new dedicated aspect of BioGRID annotates genome-wide CRISPR
15                           The development of dedicated assemblers for metagenomic data was a relative
16 ort an X-ray structure of human SDHA and its dedicated assembly factor SDHAF2.
17  other complex metalloenzymes, CODH requires dedicated assembly machinery to form the fully intact an
18 S plasmid proteins (Hpp) exhibit ancient and dedicated associations with plasmids, including three cl
19 rein, an integrated strategy together with a dedicated automated computational tool termed AOGP was d
20 nsors that join these photonic crystals with dedicated bioanalytical scanners based on compact disk d
21  solvent accessibility is analyzed through a dedicated bioinformatic pipeline including stringent sta
22 lus subtilis where fatty acid synthesis plus dedicated biotin enzymes produce the pimelate moiety.
23 pproach that uses sparse-view acquisition in dedicated breast computed tomography for radiation dose
24                                              Dedicated breast PET (dbPET) is a high-resolution imagin
25          PtmO3 and PtmO6 represent the first dedicated C7 beta-hydroxylases characterized to date and
26     Together, our data suggest that NS2 is a dedicated Ca(2+) binding protein and that calcium sensin
27  with an expert team outfitted with PPE in a dedicated CCL room.
28 highly prone to misfolding and often require dedicated chaperones to prevent aggregation.
29 alt hydrophobicity, or increased activity of dedicated cholesterol and phospholipid transporters.
30 ng patient-derived xenografts we constructed dedicated classifiers for experimental models.
31 c allergy clinics in the UK have funding for dedicated clinical psychology services.
32 r specific radiologic-biologic advantages in dedicated clinical situations.
33     Here, we report the results of the first dedicated clinical trial of (18)F-ISO-1 in women with pr
34 g to reveal how macromolecular assemblies of dedicated clock proteins form and evolve to contribute t
35 he cylindric phantom and bone scans were the dedicated CNNs.
36 microfluidic cartridge is operated through a dedicated compact instrument providing fully automated f
37                        Materials and Methods Dedicated compressed sensing-based slice encoding for me
38 ainful syndromes, by the implementation of a dedicated computational pipeline empowering different an
39 ombination of yeast two-hybrid screening and dedicated confirmations with bimolecular fluorescence co
40 ing 40 276 patients amounted to 614 825 kWh, dedicated cooling systems to 492 624 kWh, representing 4
41          Hence, 9 novel tracers that combine dedicated copper chelators with the PSMA-specific urea-b
42    Isolation room numbers almost tripled and dedicated COVID-19 cohort wards were established, electi
43                  Within available resources, dedicated COVID-19-free surgical pathways should be esta
44                                              Dedicated CSD methods managed to discover graphs that ne
45  multiple methods, including assessment in a dedicated daily emergency clinic and daily review of all
46 ergic agonistic activity on cAMP generation (dedicated dataset generated for this study) and EGFR inh
47 r, continuous-bed-motion (CBM) scans require dedicated DDG approaches for axially extended PET, compa
48 d polyp detection and reader confidence in a dedicated dual-energy CT colonography phantom, especiall
49 hat interact with the K63 polyubiquitination-dedicated E2s UBC35/36 and their cognate E2 variants, in
50 omoendoscopy if performed by experienced and dedicated endoscopists.
51  determine the safety and effectiveness of a dedicated endovenous stent for symptomatic iliofemoral v
52 ce - have revealed that chromatin structure, dedicated enhancers and transcriptional networks are reg
53 NA degradation as a step-wise process with a dedicated enzyme for the clearance of a specific interme
54 cins and/or with the gene encoding the first dedicated enzyme in the crocin biosynthetic pathway, CsC
55                                          The dedicated enzyme, RubisCO, has a low turnover and poor s
56 omoters of AcANS and AcF3GT1 that encode the dedicated enzymes for anthocyanin biosynthesis.
57 r polypeptides whose modification by various dedicated enzymes helps to establish a vast array of che
58 pidly produced or interconverted by a set of dedicated enzymes.
59          Through bioinformatics analysis and dedicated experiments, we identify mTORC1 signalling as
60                                              Dedicated expertise is needed to optimize outcomes for t
61 as the GET pathway controls ER-targeting, no dedicated factors are known for OMM insertion, posing th
62 sternal during mitosis is controversial, and dedicated factors governing the morphology of the mitoti
63 nts from May 2012 to December 2018 underwent dedicated ferumoxytol-enhanced MR venography of the thor
64 ted silica microspheres, interrogated with a dedicated fiber-optic phase-sensitive luminometer.
65 The photometric detection is performed using dedicated flow-through optoelectronic detector made of p
66  highly effective voltammetric enantiosensor dedicated for determination of thalidomide (TD) enantiom
67 ges commercially available on Polish market, dedicated for infant 0-8 months.
68  enzyme activity in some dietary supplements dedicated for people suffering from lactose intolerance.
69 e and sex matched healthy controls using the dedicated Freesurfer pipeline.
70  automated system, based on eye tracking and dedicated full occlusion glasses, was developed to provi
71                      Residents were provided dedicated, full-time immersion into the CCDS work enviro
72 ng B lymphocytes and myelocytes within their dedicated functional environment.
73 megmatis form drug-tolerant biofilms through dedicated genetic programs.
74 d PIWI-interacting RNAs (piRNAs) produced by dedicated genomic loci called piRNA clusters.
75 al networks (CNNs), which may be embedded in dedicated hardware.
76 e meglumine underwent 3.0-T brain MRI with a dedicated head coil, including T1 mapping and magnetizat
77 gical or biotechnological origin demands for dedicated high efficiency separation methods, due to ide
78 g local, regional and statewide systems with dedicated high-performing cardiac resuscitation centres
79 e a privileged E3 for the proteasome, with a dedicated, high affinity binding site contributed by hRp
80  SIRT6 as a Pol II promoter-proximal pausing-dedicated histone deacetylase.
81                            To control CP1-3, dedicated hubs integrate the antagonistic mitogenic and
82               When combined with advances in dedicated image analyses and processing methods, details
83                                          The dedicated image processing algorithms were used for extr
84                                       With a dedicated image processing pipeline, PB-X-PCI images are
85 secondary ion mass spectrometry analyses and dedicated image processing, allows us to image how resou
86 ssessment of the myelination status requires dedicated imaging, but the conventional T(2)-weighted sc
87 l-kynurenine (l-Kyn), which is supplied by a dedicated indoleamine-2,3-dioxygenase NanC encoded in th
88 iluminescence (ECL) research is the need for dedicated instrumentation or highly customized cells to
89                   Overall, we propose that a dedicated iron-acquisition protein complex exists at the
90 ae, we demonstrate that human cMLCK is not a dedicated kinase for RLC but can phosphorylate other sar
91 and demonstrate that sour taste uses its own dedicated labeled line from TRCs in the tongue to finely
92 uires several sample preparation steps and a dedicated laboratory environment, precluding a high thro
93   A large number of practices do not require dedicated land, including several land management option
94 y by Prescott and Umans et al. reveals how a dedicated laryngeal sensory motor reflex circuit protect
95           Thus, the cancer variant remains a dedicated leading-strand polymerase with markedly low ac
96 sing an affordable consumer-grade 3D printer dedicated LOV platforms are 3D printed at will and print
97 ocesses were experimentally deconvolved in a dedicated lysimeter study considering three scenarios.
98  into a chain and positioned at midcell by a dedicated magnetosome-specific cytoskeleton, the "magnet
99 ple multiplexing format, avoiding the use of dedicated mass spectrometry-based procedures.
100     The assembly of this cofactor requires a dedicated maturation machinery including HydF, a multido
101                         Our results indicate dedicated mechanisms that enable rapid transcription inv
102  been proposed that each TF interacts with a dedicated MED subunit to induce specific transcriptional
103      This Perspective highlights some of the dedicated medicinal chemistry efforts directed at inhibi
104 ysfunctional mitochondria and other cargo in dedicated membranous particles reminiscent of neural exo
105 ssion and functions; they can originate from dedicated miRNA genes, from non-canonical miRNA genes, o
106 ent types of transplant centers can set up a dedicated MNA program according to available resources t
107 f conducting elemental characterization of a dedicated model multilayer sample composed of 100 nm thi
108  of these methods are verified using a novel dedicated model sample consisting of Al nanoparticles bu
109 we propose that an evolutionarily conserved, dedicated molecular network has evolved to allow differe
110  parameters (S-parameter) are received via a dedicated moving transmitting and receiving antenna set-
111 nent intestinal failure should be managed by dedicated multidisciplinary intestinal rehabilitation te
112 etected during screening should be made by a dedicated multidisciplinary team together with the high-
113 dized algorithm, and data were reviewed by a dedicated multidisciplinary team.
114 for retinal regeneration, whereas in mice, a dedicated network suppresses neurogenic competence and r
115                              There is also a dedicated neural network for face processing in primates
116 o the membrane of the ER and activates an ER-dedicated NMD pathway, thus providing an ER-protective f
117  to the different structural requirements of dedicated nuclear or hybrid imaging agents.
118 rodecameric complex that functions as eIF2's dedicated nucleotide exchange factor.
119 ve ascertainment of the robustness of a PrEP-dedicated nurse-led implementation strategy.
120  tumor characteristics were available from a dedicated ocular database.
121 e evolutionary implications of the loss of a dedicated olfactory organ in spiders and its effects on
122                                              Dedicated oncology tumor response software was used.
123  OPAT from 2 academic medical centers with a dedicated OPAT clinic for management.
124 s complicated, and to date there has been no dedicated or easy-to-use software to automate the proces
125  gradient and coupling to the ICP-sfMS via a dedicated organic matrix interface (RPC-ICP-sfMS).
126  mum, although it has not been accepted by a dedicated organization.
127 rge CdiA toxins across the outer membrane by dedicated outer membrane transporters called CdiB.
128 e offered confirmatory testing and care at a dedicated outpatient clinic.
129       We present BioStructures.jl, the first dedicated package in the Julia programming language for
130                                              Dedicated pathological and radiological reviews were per
131           In Uganda, the implementation of a dedicated pediatric OR has an ICER of $37.25 per disabil
132                  The method was validated in dedicated phantom and then applied to 12 consecutive pat
133                                         In a dedicated pharmacokinetic study to compare GFR with tubu
134 monitoring for patients with COVID-19, and a dedicated phone hotline platform.
135 to the mitoribosomal small subunit through a dedicated platform formed by the mitochondria-specific p
136 positive valence as well, and thus a lack of dedicated polarity.
137 hat individual molars are each targeted by a dedicated population of about 50 specialized trigeminal
138           These experiments establish that a dedicated population of PAG neurons gives rise to a desc
139                                            A dedicated portal has been developed to provide quick and
140                                              Dedicated post-processing exploiting the known CPMG spik
141 ed with existing LPA technology, calling for dedicated pre-clinical studies.
142 y available scientific manuscripts posted on dedicated preprint servers prior to journal-managed peer
143               Now is the time to establish a dedicated preventive cardiology subspecialty to train th
144                    Doa10 cooperates with the dedicated priming E2, Ubc6, while both E3s use Ubc7 for
145   Here, we developed a generic method with a dedicated processing workflow to obtain these two sets o
146                                            A dedicated programmable sample flow rate scanner was used
147 n severe mitral annular calcification with a dedicated prosthesis is feasible and can result in MR re
148 eria, type VII secretion systems (T7SSs) are dedicated protein transport machineries that fulfill div
149                          Prototypic Tn7 uses dedicated proteins for two targeting pathways: one targe
150                        C-di-GMP binds to the dedicated pseudoreceiver domain Rec1, thereby liberating
151 the companion neutron star, as measured by a dedicated pulsar timing campaign, are 1.62 +/- 0.03 and
152 t analysis using either the web-interface, a dedicated Python package, or custom remote clients.
153 ection to isolate themselves at home or in a dedicated quarantine facility.
154                                           No dedicated randomised clinical trials have evaluated ther
155 nerating and need to be replicated in future dedicated randomized trials.
156 ency; however, the relationship between such dedicated research during general surgery residency and
157 variants being identified has necessitated a dedicated resource with custom tools for curation and pu
158 ned by these molecular features require that dedicated resources be used to assist the discovery of d
159  and the analytes are preconcentrated onto a dedicated reversed-phase solid-phase extraction (Oasis P
160  focused on conversion-type materials, but a dedicated review for this group of materials is missing
161 ormation of the suspension without using any dedicated rheological technique.
162  telomerase RNP core enzyme is composed of a dedicated RNA subunit and a reverse transcriptase (telom
163  most often created by novel combinations of dedicated RNA-binding modules.
164 yme, encoded by PLC21C, presumably playing a dedicated role in clock resetting.
165     Here, we provide in vivo evidence that a dedicated S-adenosylmethionine-dependent methyltransfera
166         Many Gram-negative pathogens utilize dedicated secretion systems to export virulence factors
167                     This article encompasses dedicated sections on the full spectrum of the pressure
168 ting observational data sets and a series of dedicated sensitivity experiments, we show that the seve
169                              The creation of dedicated sepsis guidelines and their broad disseminatio
170           Habitat models were developed from dedicated sighting survey data collected by NOAA- Northe
171                  Bacteria and archaea employ dedicated signal transduction systems that modulate gene
172 d to scRNA-seq data, partially outperforming dedicated single-cell tools.
173 ombining a low-dose acquisition method and a dedicated single-electron detector for recording the dif
174 omputing clusters (most easily by invoking a dedicated Singularity image).
175  nodes (LNs) are strategically positioned at dedicated sites throughout the body to facilitate rapid
176 )F]-Florbetapir uptake in the 5xFAD brain by dedicated small-animal PET/MRI and PET/CT to validate th
177 on and 4D flow analysis were performed using dedicated software.
178 orescence images were also evaluated using a dedicated software.
179 ay supplemented by resolution recovery using dedicated software.
180            We provide evidence in support of dedicated spinal network components that are controlled
181               Specific stress stimuli prompt dedicated stress kinases to phosphorylate eukaryotic ini
182 nd medical risk stratifications are based on dedicated, strictly controlled clinical trials.
183 t of acute ischemic stroke, and treatment in dedicated stroke centers can significantly reduce stroke
184 versal of associated coagulopathy, care in a dedicated stroke unit, and identification of secondary e
185 r, is limited because they typically require dedicated structural features in the enzyme, such as a n
186 ot be fully compensated for by the two other dedicated substrate receptors (hRpn1 and hRpn10).
187 n, contrast-enhanced carotid MRI at 3T using dedicated surface coils.
188  transmission to the host population is low, dedicated surveillance and tailored public health polici
189 teins harbor targeting signals recognized by dedicated targeting pathways.
190 cians, nurses and physiotherapists, multiple dedicated teams performed daily multiple PP following a
191                       All patients seen at a dedicated tertiary referral center for a suspicion of va
192 rame, we have embarked upon writing software dedicated to (13)C NMR dereplication.
193 timescale despite the presence of mechanisms dedicated to Abeta clearance is still lacking.
194 nate HBV (ICE-HBV) is a coalition of experts dedicated to accelerating the discovery of a cure for ch
195 are unique and provide specialised functions dedicated to achieving placental development and success
196 nsive time and financial resources have been dedicated to address nonpoint sources of nitrogen and ph
197  research and clinical investigation efforts dedicated to advancing both endogenous and synthetic imm
198 ts in a traceless manner, and this review is dedicated to all aspects of traceless solid-phase organi
199 ntact map, we propose a computational method dedicated to analyzing interchromosomal interactions of
200                Significant efforts have been dedicated to artificial photosynthesis mimicking nature
201                             The limited work dedicated to assess methods based on of SVM for binary c
202 nd a polytopic glycosyltransferase (PolM GT) dedicated to attaching sugar residues to a specific glyc
203 alysis is not optimized for a given size but dedicated to characterize broad groups of particles of v
204 ly, it is now a highly competitive technique dedicated to characterizing small molecules, proteins, m
205         The replisome, the molecular machine dedicated to copying DNA, encounters a variety of obstac
206  ecosystems is moving from preliminary steps-dedicated to defining the optimal features for indicator
207  the same cells or by populations of neurons dedicated to detecting serotonin at different concentrat
208         Although extensive efforts have been dedicated to developing catalysts for hydroamination, th
209       Diat.barcode is an open-access library dedicated to diatoms which has been maintained since 201
210 population, bORNs provide a neural mechanism dedicated to encoding the time between odor encounters.
211    Here, we identify a localized NMD pathway dedicated to ER-translated mRNAs.
212 s this issue, extensive research efforts are dedicated to exploiting all-inorganic PVSCs by using ces
213 re is a multi-billion dollar global industry dedicated to feeding wild birds in residential gardens.
214 ast, the inosine monophasphate dehydrogenase dedicated to guanosine synthesis, GuaB2, displayed the o
215  shows that a majority of this processing is dedicated to h-t flow detection, and this is reinforced
216 ciety for Cell Biology (ASCB) is a community dedicated to helping prepare the next generation of scie
217   G8 is a benchtop integrated PET/CT scanner dedicated to high-sensitivity and high-resolution imagin
218               Recently, specific macrophages dedicated to homeostatic peripheral nerves have come int
219      As a part of metabolomics and initially dedicated to identifying bioactive natural products, der
220 nsiderably less attention, however, has been dedicated to identifying unknown metabolic pathways.
221 dicines for Malaria Venture, an organization dedicated to identifying, developing and delivering new
222             Resources should be specifically dedicated to improving seasonal influenza vaccines while
223 utagenesis is MutY/MutM1, and this system is dedicated to in situ chromosomal oxidation rather than c
224 n cells where most translation regulation is dedicated to inefficiently translated AU-rich mRNAs, whe
225                Bacteria have evolved systems dedicated to interbacterial competition.
226 taminergic itch, and GRP sensory neurons are dedicated to itch transmission.
227 nal uses; however, little attention has been dedicated to its potential for the bio production of act
228 am of cmaA2 encoding a cyclopropane synthase dedicated to keto- and methoxy-MAs.
229 hantoms of tissue with diamond nanoparticles dedicated to magnetic resonance calibration.
230 r example, the expression levels of proteins dedicated to metabolism and biosynthesis(1,2).
231 mary target of host-directed immunotherapies dedicated to neonates.
232 m bulk sample processing to clean facilities dedicated to nuclear forensic investigation of environme
233 ed for improving ab-initio software packages dedicated to numerical simulations in physical-chemistry
234       Finally, we present a first XPEEM cell dedicated to operando/in situ experiments in all-solid-s
235  learning-the field of machine learning (ML) dedicated to optimal experiment design-has played a part
236 ndependent hippocampal code: an 'event code' dedicated to organizing experience by events as discrete
237 ent Tensorpac, an open-source Python toolbox dedicated to PAC analysis of neurophysiological data.
238 A since 1928, with a special issue each year dedicated to papers presented before the ASA Annual Meet
239 arried-out with a digital mammography device dedicated to performing dual-energy CESM acquisitions.
240            Only a few software solutions are dedicated to PNP analysis but with a mutually exclusive
241 al Pacific and substantial efforts have been dedicated to predicting its occurrence and variability b
242 ty of the studies have focused on DS neurons dedicated to processing the optic flow generated during
243   TReND is a volunteer-scientist run charity dedicated to promoting research and education on the Afr
244 f the total proteome mass in all kingdoms is dedicated to protein homeostasis and folding, highlighti
245 re discovered as independent processes, each dedicated to remove specific types of lesions, but the p
246 asmid showed a completely conserved backbone dedicated to replication, stability, and mobilization as
247 bonucleoprotein particle assembly, primarily dedicated to ribosome biogenesis.
248 ing that bursts act as a unit of information dedicated to spatial coding.
249 hosphatidylinositol 4-phosphate (PtdIns(4)P) dedicated to specific biological outcomes.
250 ailed understanding of the components of OCR dedicated to specific molecular events remains lacking.
251 ghput sequencing (HTS) database, LabxDB seq, dedicated to storage of hierarchical sample annotations.
252 investment in policymaker-scientist networks dedicated to such translation for a range of diseases.
253 cterial phosphonate biosynthetic capacity is dedicated to tailoring cell surfaces with molecules like
254 the small interfering RNA (siRNA) pathway is dedicated to TE somatic control and defense against viru
255 romatography-tandem mass spectrometry method dedicated to the analysis of polar water contaminants.
256                              For researchers dedicated to the cause, thorough experimental standards
257                      Many investigations are dedicated to the detection and quantification of reactiv
258           While considerable effort has been dedicated to the development of countermeasures, impleme
259           Even though some efforts have been dedicated to the discrimination of alpha2,3/alpha2,6-sia
260 view of the lysosome from a static organelle dedicated to the disposal and recycling of cellular wast
261 on of multidisciplinary data while remaining dedicated to the FAIR principles of data management (fin
262 ars, several proteome-wide studies have been dedicated to the identification of RNA-binding proteins.
263                              This article is dedicated to the memory of Michael G.
264                           A brief section is dedicated to the novel concept of rejuvenation or regene
265  were marked by H3K27me3, which is otherwise dedicated to the transcriptional repression of protein-c
266 ique neuro-cognitive functions, specifically dedicated to the use of pen and the ability to transform
267 enomes encode a large repertoire of proteins dedicated to the utilization of diverse plant polysaccha
268 ly benefited from new theoretical approaches dedicated to their electronic structures and optoelectro
269 s and attendees of international conferences dedicated to this topic.
270 nt role in cell physiology and is not simply dedicated to toxin biogenesis.
271 recently developed pharmacological treatment dedicated to transthyretin amyloidosis.
272 Chris's major contributions: his early work, dedicated to understanding protein-folding mechanisms; h
273 aterfowl surveillance efforts by researchers dedicated to understanding the ecology of IAV and its su
274 ld have formed TERAVOLT, a global consortium dedicated to understanding the impact of COVID-19 on pat
275 ore, a significant portion of this review is dedicated to various biological applications of DNAzymes
276 ong with a critique of the experimental work dedicated to various virus sensors, and a summary of the
277 y organized thalamic nucleus that is largely dedicated to visual processing.
278 the population level, an application that is dedicated to visualizing population genetic test statist
279 se of greenness assessment criteria requires dedicated tools.
280                   While much effort has been dedicated toward this goal by using a directed C-H activ
281 pis mellifera) encode spontaneously, without dedicated training, various statistical properties of no
282                                              Dedicated transgender clinics are planned to provide com
283 ion with an LPA beam based manipulation in a dedicated transport line with versatile properties.
284 to and out the nucleus through the action of dedicated transport receptors importin-9 and exportin-6,
285 e lipid bilayer impermeable and thus rely on dedicated transport systems to cross biological membrane
286 lmitoleation and subsequent loading onto the dedicated transporter Wntless/evenness interrupted (WLS/
287 iosynthesis pathways despite the presence of dedicated transporters.
288 ral valves were implanted in 10 pigs using a dedicated transseptal delivery system.
289              Achieving this aim will require dedicated trials with these drugs in both patients who h
290  and SCD repressed proliferation-revealing a dedicated tRNA-regulated growth-suppressive pathway for
291 a self-expanding nitinol stent developed for dedicated use in the venous system (Vici Venous Stent Sy
292 esis; thus, there appears to be no direct or dedicated vacuole-to-mitochondria iron trafficking pathw
293 lves this image fusion problem through a new dedicated variant of the multivariate curve resolution-a
294  substantially across indications, also with dedicated venous nitinol stents.
295 hese viruses, episome maintenance requires a dedicated virus-encoded episome maintenance protein (EMP
296  product of a full year's worth of effort by dedicated volunteer clinicians and scientists, committed
297                        This collection has a dedicated web form to engage the community in the curati
298  RNAs are post-transcriptionally modified by dedicated writer or eraser enzymes that add or remove sp
299  and exopolysaccharide (EPS) are produced by dedicated Wzx/Wzy-dependent polysaccharide-assembly path
300               Here, we show that DNGR-1 is a dedicated XP receptor that signals upon ligand engagemen

 
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