ライフサイエンスコーパス: dedifferentiated

1 d enriched among cells that were injured and dedifferentiated.

2 cytoskeleton-related genes, and these cells dedifferentiated.

3 erous or clear cell, 3 carcinosarcoma, and 4 dedifferentiated.

4 s, and these SMCs are hyperproliferative and dedifferentiated.

5 1 isoform A3 (ALDH(+)) as beta cells become dedifferentiated.

6 Plant cells rapidly dedifferentiated.

7 resented with well-differentiated, 143 (18%) dedifferentiated, 144 (18%) myxoid, 81 (10%) round cell,

8 quently amplified in G2 (15%), G3 (20%), and dedifferentiated (21%) chondrosarcomas.

9 constructed tissue microarrays containing 42 dedifferentiated, 23 clear cell, and 23 mesenchymal chon

10 e 1 (18%), grade 2 (31%), grade 3 (80%), and dedifferentiated (29%) chondrosarcomas, but was not foun

11 nted with well-differentiated, 65 (37%) with dedifferentiated, 9 (5%) with myxoid, and 4 (2%) with ro

12 ancreatic injury, elimination of Numb causes dedifferentiated acinar cells to undergo apoptosis, and

13 Chondrocytes in monolayer become dedifferentiated, acquiring a fibroblast-like appearance

14 state of differentiation because SCs rapidly dedifferentiated and became competent to resume prolifer

15 or progenitor cells or from cells that have dedifferentiated and become proliferative.

16 Oct4alo BCCs dedifferentiated and colocalized with MSCs (murine and h

17 Claudin-3-/- mice revealed dedifferentiated and leaky colonic epithelium, and devel

18 induced clusters of proliferative cells that dedifferentiated and lost epithelial characteristics.

19 p of tumors in Arf(-/-) animals presented as dedifferentiated and metastatic, with many characteristi

20 , reduces invasion, and induces apoptosis in dedifferentiated and myxoid/round cell liposarcoma cell

21 Perilipin 2 was more prominent in dedifferentiated and pleomorphic liposarcomas and nearly

22 e expressed in epicardial cells that enclose dedifferentiated and proliferating cardiomyocytes during

23 KIM1, VIMENTIN, SOX9, and KI67, indicating a dedifferentiated and proliferative state.

24 olecule up-regulated in the cells, which are dedifferentiated and undergoing replication.

25 Fibrosarcoma, leiomyosarcoma, dedifferentiated, and myxoid liposarcoma cell lines were

26 as quickly down-regulated and disappeared in dedifferentiated ASMC in culture.

27 In this study, we confirmed that transformed dedifferentiated astrocytes and neurons acquired a stem/

28 pmentally stalled neural progenitors or from dedifferentiated astrocytes?

29 This model predicts that dedifferentiated B-cells resemble B-cell progenitors.

30 spite some similarities between immature and dedifferentiated B-cells, B-cell dedifferentiation in th

31 ssing five subtypes, (a) well-differentiated/dedifferentiated, (b) myxoid/round cell, and (c) pleomor

32 transition from the classical subtype to the dedifferentiated basal-like/squamous subtype of pancreat

33 Dedifferentiated beta cells reverted to progenitor-like

34 At an early stage, melanoma cells showed a dedifferentiated c-Jun(high)/MITF(low) phenotype, possib

35 quired for survival and proliferation of the dedifferentiated cancer cell.

36 lial cell preservation and conversion into a dedifferentiated cancer stem cell-like phenotype depends

37 t encompasses well-differentiated as well as dedifferentiated cancer types.

38 could be detected in similar assays with the dedifferentiated cell line HepG2.1 or the nonhepatic cel

39 Melanomas can switch to a dedifferentiated cell state upon exposure to cytotoxic T

40 g of IPF-ABC towards a KRT17(high) PTEN(low) dedifferentiated cell type.

41 val may be manifested by the production of a dedifferentiated cell with broader potential and that th

42 eration, we find no evidence to suggest that dedifferentiated cells acquire a ductal fate during this

43 We find that dedifferentiated cells adopt a progenitor-like fate due

44 , the proliferation and the migration of the dedifferentiated cells are dependent on Hh signaling.

45 transcription factors and that diseased and dedifferentiated cells can be returned to normal functio

46 transition, and exogenous PHD2 expression in dedifferentiated cells can restore an epithelial phenoty

47 and three IR-resistant clones isolated from dedifferentiated cells have acquired the ability to prol

48 RNAi-mediated knockdown of Oct4 in dedifferentiated cells led to diminished CSC phenotypes.

49 Upon various challenges, the dedifferentiated cells proliferate and redifferentiate i

50 n organized structure of lineage restricted, dedifferentiated cells that cooperate to regenerate the

51 erogeneous population of lineage-restricted, dedifferentiated cells that ultimately orchestrates rege

52 Finally, IL1 produced by dedifferentiated cells was involved in the inhibition of

53 Dedifferentiated cells were morphologically indistinguis

54 order to perform genetic lineage tracing of dedifferentiated cells while measuring the cellular tran

55 Factors secreted by dedifferentiated cells, but not by melanocytic cells, st

56 lular matrix, and proliferation of partially dedifferentiated cells, evidence strongly supports the l

57 e can restore chondrocyte gene expression in dedifferentiated chondrocytes grown on plastic.

58 Subsequent culture of the dedifferentiated chondrocytes in 3-dimensional alginate

59 Culture of dedifferentiated chondrocytes in alginate gel induces a

60 as 2-3-fold greater in nuclear extracts from dedifferentiated chondrocytes than in nuclear extracts f

61 in complex formed with nuclear extracts from dedifferentiated chondrocytes were 2-3-fold greater than

62 binding activity between differentiated and dedifferentiated chondrocytes.

63 ition with the BH-3 mimetic ABT-737 rendered dedifferentiated chondrosarcoma cell lines sensitive to

64 The mesenchymal, clear cell, and dedifferentiated chondrosarcoma subtypes are extremely r

65 comas, one pleomorphic rhabdomyosarcoma, one dedifferentiated chondrosarcoma, and one malignant perip

66 a survivors; the benefit of chemotherapy for dedifferentiated chondrosarcomas remains questionable; a

67 lanted from the Myh11(R247C/R247C) mice were dedifferentiated compared with wild-type SMCs based on i

68 ve rise to drug-dependent progeny than their dedifferentiated counterparts.

69 d TGF-beta down-regulated GKLF expression in dedifferentiated cultured SMCs.

70 adipose tissue and well differentiated from dedifferentiated disease.

71 Insulin-producing beta cells become dedifferentiated during diabetes progression.

72 , SMARCA4-deficient thoracic sarcomas(6) and dedifferentiated endometrial carcinomas(7).

73 Conversion of SECs to a capillarized, dedifferentiated endothelium was confirmed at the cellul

74 lia promotes BMP7 signaling in repopulating, dedifferentiated epithelia.

75 KC and KCR8-16 mice developed dedifferentiated exocrine pancreata within 2 months of a

76 liferation were seen in conjunction with the dedifferentiated expression of cytokeratins 1, 10 and 5,

77 Porcine dedifferentiated fat (PDFAT) cells were clonally isolate

78 own progenitors, we cultured white and brown dedifferentiated fat (wDFAT and brDFAT) cells from mouse

79 Human SMCs are first dedifferentiated for 4 days to achieve a vascular progen

80 Tumors derived from dedifferentiated germ cells, however, respond to the pro

81 in germline stem cell overproliferation and dedifferentiated germline stem cells.

82 undergoes pX-dependent transformation and a dedifferentiated hepatocyte (AML12) 4pX-1 cell line that

83 addition of hydrated matrix preparations to dedifferentiated hepatocytes.

84 rs by transient-transfection analysis in the dedifferentiated hepatoma cell line, HepG2.1.

85 plastic tissue culture flasks as monolayers (dedifferentiated HFC cultures).

86 he RPE, were significantly down-regulated in dedifferentiated hfRPE cells.

87 ted primary human fetal RPE (hfRPE) cells to dedifferentiated hfRPE cells.

88 ferentiation that was also down-regulated in dedifferentiated hfRPE cells.

89 8 mm), node negative in 93.4% of cases, and dedifferentiated (high-grade cancer) in 41.7% of cases a

90 Dedifferentiated histologic subtype and the need for con

91 Risk of recurrence is high for patients with dedifferentiated histology or retroperitoneal location.

92 The exocrine-enriched cells rapidly dedifferentiated in culture and grew as a mesenchymal mo

93 decidual cells from patients with sPE, which dedifferentiated in vitro, failed to redecidualize in cu

94 etic marks, and the mature B cells partially dedifferentiated, induced RAG-1 and -2 along with certai

95 ence, there is no apparent requirement for a dedifferentiated intermediate during the transdifferenti

96 tially dispensable but becomes essential for dedifferentiated intermediates to transit to ground stat

97 y enlarged, disorganized, and in some cases, dedifferentiated into a callusoid mass.

98 strated that the luminal secretory cells had dedifferentiated into basal stem cells.

99 r hepatocyte loss, BECs proliferated as they dedifferentiated into hepatoblast-like cells; they subse

100 Single secretory cells clonally dedifferentiated into multipotent stem cells when they w

101 This is consistent with EZH2-driven dedifferentiated invasive states associated with treatme

102 pe, we engineered MDA-MB-231 cells, a highly dedifferentiated, invasive breast cancer cell line, to e

103 lanoma cells have the ability to switch to a dedifferentiated, invasive phenotype in response to mult

104 have a similar expression pattern to that of dedifferentiated islets.

105 compatible either with myeloid cell or with dedifferentiated Langerhans cell antigens, carry the BRA

106 Many dedifferentiated, late-stage tumors are resistant to gro

107 models and a phase I study of patients with dedifferentiated liposarcoma (DD-LPS) was observed with

108 patients with unresectable and/or metastatic dedifferentiated liposarcoma (DDLPS) are limited.

109 Dedifferentiated liposarcoma (DDLPS) is a highly maligna

110 Dedifferentiated liposarcoma (DDLPS) is frequently diagn

111 ecimens of WDLPS, and of the closely related dedifferentiated liposarcoma (DDLPS) subtype, revealed i

112 es substantially recover the leiomyosarcoma, dedifferentiated liposarcoma (DDLPS), and synovial sarco

113 and expression of FRS2 with CDK4 and MDM2 in dedifferentiated liposarcoma (DDLS) and undifferentiated

114 e well differentiated liposarcoma (WDLS) and dedifferentiated liposarcoma (DDLS), both characterized

115 ith well-differentiated liposarcoma and G1-2 dedifferentiated liposarcoma (G1-2 DDLPS, n=266) treated

116 tissue, well-differentiated liposarcoma, and dedifferentiated liposarcoma by both deep sequencing of

117 In the human dedifferentiated liposarcoma cell line (LS141) and the p

118 assigned an important role in the growth of dedifferentiated liposarcoma cell lines.

119 ially induces apoptosis and growth arrest in dedifferentiated liposarcoma cells compared with normal

120 Extracellular vesicles derived from dedifferentiated liposarcoma cells induce oncogenic prop

121 Restoring miR-143 expression in dedifferentiated liposarcoma cells inhibited proliferati

122 iated pleomorphic sarcoma and pleomorphic or dedifferentiated liposarcoma of the extremity, which est

123 d checkpoint pathways in well-differentiated/dedifferentiated liposarcoma provides several possible n

124 Dedifferentiated liposarcoma represents focal progressio

125 Multivariate analysis showed that dedifferentiated liposarcoma subtype was associated with

126 Retroperitoneal dedifferentiated liposarcoma was associated with an 83%

127 logies were well-differentiated liposarcoma, dedifferentiated liposarcoma, and leiomyosarcoma.

128 ased knockdown of several genes amplified in dedifferentiated liposarcoma, including CDK4 and YEATS4,

129 or its targets may have therapeutic value in dedifferentiated liposarcoma.

130 with undifferentiated pleomorphic sarcoma or dedifferentiated liposarcoma.

131 ng seven (47%) of 15 evaluable patients with dedifferentiated liposarcoma.

132 in undifferentiated pleomorphic sarcoma and dedifferentiated liposarcoma.

133 ograft models from surgically resected human dedifferentiated liposarcoma.

134 d in > 90% of well-differentiated (WDLS) and dedifferentiated liposarcomas (DDLS).

135 Well-differentiated/dedifferentiated liposarcomas (WD/DDLPSs) account for ~6

136 More than 90% of well-differentiated or dedifferentiated liposarcomas (WD/DDLS) have CDK4 amplif

137 Well-differentiated and dedifferentiated liposarcomas (WDLS/DDLS) account for ap

138 le single-agent activity with milademetan in dedifferentiated liposarcomas has prompted a randomized

139 ned over 40 miRNAs that were dysregulated in dedifferentiated liposarcomas in both the sequencing and

140 cation of spectra as well-differentiated and dedifferentiated liposarcomas or normal adipose tissue w

141 hereas only the differentiated components of dedifferentiated liposarcomas were immunohistochemically

142 of undifferentiated pleomorphic sarcomas and dedifferentiated liposarcomas with low infiltrating CD3

143 In dedifferentiated liposarcomas, grade concordance was 59.

144 In the subgroup with dedifferentiated liposarcomas, the disease control rate

145 iposarcomas, 44 (25.6%) were reclassified as dedifferentiated liposarcomas.

146 -associated neochromosomes from well- and/or dedifferentiated liposarcomas.

147 the catalytic subunit alpha2, is induced in dedifferentiated liver.

148 Of these, dedifferentiated LMS with high immune infiltration and t

149 localisation remained evident in apparently dedifferentiated LNCaP cells.

150 of which well-differentiated LPS (WDLPS) and dedifferentiated LPS (DDLPS) are the most common.

151 ction and assess their biological effects in dedifferentiated LPS (DDLPS).

152 The Ad/N1ICD LPS resembles human dedifferentiated LPS in histological appearance, anatomi

153 ch inhibition suppresses the growth of human dedifferentiated LPS xenografts.

154 LR was most common in dedifferentiated LPS, in which it occurred early (24%, 3

155 Dedifferentiated, malignant leukocytes retain the benign

156 The dedifferentiated melanoma cells acquired features associ

157 The secretome of dedifferentiated melanoma cells also modulated the biome

158 Communication between dedifferentiated melanoma cells and lymph node fibroblas

159 Here we show that melanocytic and dedifferentiated melanoma cells differentially impact th

160 The dedifferentiated melanoma cells showed significantly dec

161 They also suggest that dedifferentiated melanoma cells specifically target FRC

162 ion of contractile lymph node fibroblasts by dedifferentiated melanoma cells, leading to lymph node e

163 In the dedifferentiated mesenchymal CT26 cells, TGFbetaRII-dn c

164 uro-COVID patients exhibited an expansion of dedifferentiated monocytes and of exhausted CD4(+) T cel

165 Compared to parental cardiomyocytes, dedifferentiated mouse cardiomyocyte-derived CPCs (mCPCs

166 and that they were induced in proliferating, dedifferentiated Muller glia.

167 nts >/= 18 years with advanced or metastatic dedifferentiated, myxoid/round cell, or pleomorphic LPS

168 riovenous fistula samples after occlusion by dedifferentiated neointimal VSMC.

169 Here, we found that subpopulations of dedifferentiated neoplastic breast epithelial cells expr

170 We detected this dedifferentiated neural crest subpopulation in all estab

171 xpressed with keratins, thus presenting as a dedifferentiated or interconverted (between epithelial a

172 III undifferentiated pleomorphic sarcoma or dedifferentiated or pleomorphic liposarcoma of the extre

173 e frequently co-mutated in highly aggressive dedifferentiated or undifferentiated endometrial carcino

174 firmed that new bone cells do not arise from dedifferentiated osteoblasts under these conditions.

175 dence that Notch signaling is reactivated in dedifferentiated pancreatic cells.

176 ons or cancer, KRAS with CDKN2A loss develop dedifferentiated pancreatic ductal adenocarcinomas.

177 Prolonged Notch activation within dedifferentiated parietal cells eventually enhances cell

178 % cell death, and surviving RPTCs acquired a dedifferentiated phenotype (e.g. elongated morphology an

179 days after induction, adult CMs presented a dedifferentiated phenotype and increased proliferation i

180 de that ERalpha activation switched SMC to a dedifferentiated phenotype and may contribute to plaque

181 The dedifferentiated phenotype depended on unbalanced EZH2 a

182 C/R247C) SMCs to a Rho activator rescued the dedifferentiated phenotype of the SMCs.

183 lved in this process, wherein they express a dedifferentiated phenotype that transiently resembles ne

184 resulted in the opposite effect and led to a dedifferentiated phenotype via a different G protein pat

185 Latently infected T cells exhibited a dedifferentiated phenotype, characterized by the loss of

186 Adenovirus transformed cells have a dedifferentiated phenotype.

187 LK1 overexpression induces clonogenicity and dedifferentiated phenotypes in hepatoma cells.

188 tch Schwann cells between the myelinated and dedifferentiated phenotypes, respectively.

189 together with previous reports showing that dedifferentiated Pkd1-deficient cells express lower p53

190 e vegetative nucleus of pollen grains and in dedifferentiated plant cell cultures.

191 Human metastatic melanoma cells express a dedifferentiated, plastic phenotype, which may serve as

192 ynovial sarcomas (SySa), well-differentiated/dedifferentiated/pleomorphic and myxoid liposarcomas (ML

193 markedly decreased in the proliferating and dedifferentiated podocytes of mice with anti-glomerular

194 s impaired is thought to be mediated by oval/dedifferentiated progenitor cells, which replenish the h

195 lls originate from normal stem cells or from dedifferentiated progenitor cells.

196 rnate between nondividing differentiated and dedifferentiated proliferating states in vivo.

197 recent studies show that a subpopulation of dedifferentiated, proliferating tubules recovering from

198 type from a quiescent contractile state to a dedifferentiated, proliferative and migratory state duri

199 escent vascular smooth muscle cells assume a dedifferentiated, proliferative phenotype in response to

200 topic p-Creb expression/cAMP signaling marks dedifferentiated proximal tubular cystic segments.

201 In conclusion, dedifferentiated proximal tubule cells effect proximal t

202 im1+ cells, indicating that acutely injured, dedifferentiated proximal tubule cells, rather than fixe

203 ease also had high POLR2A/RPB1 expression in dedifferentiated proximal tubule cells.

204 d high expression of RPB1 is associated with dedifferentiated proximal tubule cells.

205 high levels in human and rodent kidneys with dedifferentiated proximal tubule epithelial cells after

206 9 markers of immature nephron structures and dedifferentiated proximal tubules after acute kidney inj

207 e cells accumulated and were associated with dedifferentiated proximal tubules.

208 ion constitutes an active mechanism allowing dedifferentiated regenerating cells to scatter on denude

209 C3 was expressed in the dedifferentiated regeneration blastema and in the rediff

210 pe I transmembrane glycoprotein expressed on dedifferentiated renal proximal tubule epithelial cells

211 PDL1 expression is increased in sarcomatoid dedifferentiated renal tumours, which suggests that pati

212 d hyperdifferentiated and BRAFi/MEKi-induced dedifferentiated resistant subtypes.

213 tgrowth of cultured RPE sheets and prevented dedifferentiated RPE cell proliferation and migration.

214 ved in formation of contractile membranes by dedifferentiated RPE cells and suggest that adjunctive t

215 ibited formation of contractile membranes by dedifferentiated RPE cells on collagen I matrices.

216 ll-cell contact and demonstrate that forcing dedifferentiated RPE cells to adopt cell-cell only conta

217 ed to diminish Zeb1 expression and reprogram dedifferentiated RPE cells.

218 in nuclear translocation of beta-catenin in dedifferentiated RPE cells.

219 Furthermore, wound and distal dedifferentiated Schwann cells constitute different popu

220 Moreover, the authors show that dedifferentiated Schwann cells have the potential to coo

221 00 protein-negative cells in MPNST represent dedifferentiated Schwann cells, which harbor NF1 deletio

222 Schwannomas develop from proliferation of dedifferentiated Schwann cells, which normally wrap nerv

223 hickness and axon size distribution but some dedifferentiated SCs and increased macrophage infiltrati

224 ed lesion remodeling by altering the fate of dedifferentiated SMCs and promoting the accumulation of

225 enriched in contractile SMCs but reduced in dedifferentiated SMCs.

226 Cancer stem cells (CSCs) may be dedifferentiated somatic cells following oncogenic proce

227 es at all stages to swiftly reach a terminal/dedifferentiated stage marked by expression of chondrocy

228 esistant cells associated with a mesenchymal dedifferentiated state displayed elevated responsiveness

229 mice to adapt gene expression toward a more dedifferentiated state in response to rising blood gluco

230 uscle cells (SMC) from a differentiated to a dedifferentiated state is the critical phenotypic respon

231 r CHAF1A functions in maintaining the highly dedifferentiated state of this aggressive malignancy.

232 ls, resulting in acinar-ductal metaplasia, a dedifferentiated state that is poised for oncogenic tran

233 tment, giant cells enter a nonproliferative, dedifferentiated state, addicted to an activated cytosol

234 s that RPE are lost rather than persist in a dedifferentiated state.

235 uctive tissues and for sustained growth in a dedifferentiated state.

236 molecular identity of the differentiated and dedifferentiated states in vivo has been elusive.

237 fferentiation phenotypes from melanocytic to dedifferentiated states.

238 How dedifferentiated stem-like tumor cells evade immunosurve

239 s and progression in the well-differentiated/dedifferentiated subset.

240 differentiated "contractile" phenotype to a dedifferentiated "synthetic" one.

241 that latently HIV-1-infected T cells have a dedifferentiated T cell phenotype.

242 within the full spectrum from RAI-refractory dedifferentiated to ATC.

243 ne marrow adipocytes were highly dynamic and dedifferentiated to leptin receptor-expressing cells dur

244 te, and showed that these subtypes partially dedifferentiated towards an embryonic state and regenera

245 copy, Gb3Cer and Gb4Cer were mainly found in dedifferentiated tumor cell areas, tumor stroma, and tum

246 RNAs in progestin-mediated expansion of this dedifferentiated tumor cell population.

247 B7x is upregulated in dedifferentiated tumor cells and protects them from immu

248 city regulator SOX9, which is upregulated in dedifferentiated tumor cells, limits the number of infil

249 tumors and normal fat specimens identified a dedifferentiated tumor expression signature consisting o

250 the immunoproteasome and response and (3) a dedifferentiated tumor-intrinsic subtype with enhanced r

251 early-stage (differentiated) and late-stage (dedifferentiated) tumors.

252 ontrary to the antimotogenic effect of NO in dedifferentiated vascular smooth muscle cells (VSMCs), w

253 In vitro, the expression level of miR-21 in dedifferentiated vascular smooth muscle cells was signif

254 on of the plaque may arise from a subset of "dedifferentiated" vascular smooth muscle cells (SMCs) wh

255 proliferating bromodeoxyuridine-positive and dedifferentiated vimentin-positive epithelial cells in r

256 xpressed highly in differentiated but not in dedifferentiated VSMC.

257 could aid in reprogramming and regenerating dedifferentiated VSMCs in cerebrovascular diseases.

258 ury, the expression of ACLP increases in the dedifferentiated VSMCs of the neointima in a pattern tha

259 neointimal lesion formation and in cultured dedifferentiated VSMCs.

260 de a novel tool to target gene expression to dedifferentiated VSMCs.

261 The epithelial cell clone dedifferentiated when grown on plastic; however, the cel