ライフサイエンスコーパス: degranulate

1 rst analysis of how single cytotoxic T cells degranulate.

2 ophilic leukemia mast cells are triggered to degranulate.

3 ed by mast cells until they are activated to degranulate.

4 ylus brasiliensis, but eosinophils failed to degranulate.

5 the plasma membrane when MCs are induced to degranulate.

6 when prothrombin is activated and mast cells degranulate.

7 a fluid that accumulates in tissues when MCs degranulate.

8 ein crystals that can form after eosinophils degranulate.

9 and IFN-gamma production and the ability to degranulate.

10 inophils, and mast cells, many of which were degranulated.

11 were the most potent agonists for release of degranulating activity by endothelial cells when compare

12 ll line, RBL-2H3, are normally stimulated to degranulate after aggregation of high affinity receptors

13 Basophils that do not degranulate after anti-IgE challenge, known as "nonrelea

14 h cell granule ultrastructure and ability to degranulate after bacterial colonization.

15 These structures degranulate after chemical or mechanical stimuli that re

16 Cardiac mast cells degranulate after myocardial ischemia, releasing preform

17 As a consequence, Ets1(-/-) NK cells fail to degranulate after stimulation through activating NKRs.

18 NK cells degranulating against immune serum-opsonized HSV-1-infec

19 dministration of compound 48/80, a mast cell degranulating agent, restored BP disease in C4(-/-) mice

20 applications of compound 48/80, a mast cell degranulating agent.

21 f surface ADAM9, but activation of PMNs with degranulating agonists rapidly (within 15 min) increases

22 s and cytotoxic T lymphocytes (CTLs) fail to degranulate, although they retain the ability to produce

23 A treatment activating resident platelets to degranulate and display P-selectin.

24 ith HAM/TSP (HAM/TSP patients) spontaneously degranulate and express IFN-gamma in ex vivo unstimulate

25 the proficiency of CD56(bright) NK cells to degranulate and induce chemokine and cytokine secretion.

26 thout blocking the ability of neutrophils to degranulate and kill bacteria.

27 ed the ability of LYST-deficient NK cells to degranulate and kill target cells.

28 cells from different tissues, the ability to degranulate and kill were tightly linked to PD-1 express

29 Here, we show that dNK degranulate and kill ZIKV-infected placental trophoblast

30 YTS-NKD cells were able to degranulate and perform cytotoxicity, but they demonstra

31 individual T cell clones can degranulate or degranulate and produce cytokine depending on the Ag con

32 hese self-renewing 'memory' NK cells rapidly degranulate and produce cytokines on reactivation.

33 These two CD4 T cell effector populations degranulate and produce IFN-gamma during steady state wi

34 ility of HIV-specific CD8 and CD4 T cells to degranulate and produce IFN-gamma, TNF-alpha, and IL-2.

35 t WASp KO NK cells had decreased capacity to degranulate and produce IFNgamma upon NKp46 stimulation

36 SCF-activated eosinophils degranulate and release eosinophil peroxidase and leukot

37 meter flow cytometry, we found that NK cells degranulate and release IFN-gamma upon stimulation with

38 one marrow-derived mast cells (BMMC) fail to degranulate and release interleukin-6 (IL-6) following F

39 Toxoplasma gondii, mast cells were found to degranulate and release LTB4; this interaction damages t

40 Following its cross-linking, cells degranulate and release preformed inflammatory mediators

41 pared with resting FMs and activated them to degranulate and release reactive oxygen species, chemoki

42 tivated T cells (mvT*s) can stimulate MCs to degranulate and release several cytokines.

43 ells can stimulate human mast cells (MCs) to degranulate and release several cytokines.

44 Mast cells degranulate and release the contents of intracellular se

45 f tumor Ag as measured by their inability to degranulate and secrete IFN-gamma and granzyme B.

46 s (BMMCs) were impaired in their capacity to degranulate and secrete interleukin 6 after FcepsilonRI

47 IIa-specific mAb caused skin MC(TC) cells to degranulate and secrete PGD(2), LTC(4), GM-CSF, IL-5, IL

48 ugh the pervasive actin network at the IS to degranulate and secrete their toxic contents onto target

49 of ERK and AKT, and allowed more CD8-TILs to degranulate and to produce IFN-gamma.

50 t in the ability of btk mutant mast cells to degranulate and to secrete cytokines after the retrovira

51 Eosinophils were not degranulated and increased levels of interleukin-5 were

52 Primary human KIR3DS1(+) NK cells degranulated and produced antiviral cytokines after enco

53 imeric antigen receptors (CARs) specifically degranulated and produced effector cytokines upon stimul

54 and Dryvax were highly polyfunctional; they degranulated and produced interferon gamma, interleukin

55 erimental autoimmune encephalitis, platelets degranulated and produced soluble factors serotonin (5-h

56 In vitro, mast cells degranulated and released significant TNF in response to

57 Furthermore, most of the mast cells were degranulated and spindle-shaped in patients with acute A

58 Moreover, circulating platelets were degranulated and were found to interact with neutrophils

59 retreatment increased not only the number of degranulating and chemokine-producing mast cells but als

60 tivated/memory T cells while improving their degranulating and cytotoxic capacity compared with anti-

61 IT cells are potent cytotoxic cells, rapidly degranulating and inducing target cell death.

62 CD11b(high) phenotype, they were capable of degranulating and producing IFN-gamma upon stimulation s

63 Further, colonic eosinophils appeared to be degranulating, and the levels positively correlated with

64 in TB-IRIS were CD4+CD8- subset depleted and degranulated around the time of TB-IRIS onset.

65 problematic as islet beta cells were highly degranulated as a result of the recipients glycemic stat

66 ts of HBHA-induced CD4(+) T cell blasts that degranulate, as measured by surface capture of CD107a.

67 gement of multiple activation receptors, and degranulate at levels equivalent to WT NK cells upon coi

68 K cells from CR mice produced granzyme B and degranulated at a higher frequency than CD27(-)CD11b(+)

69 ILC3 subset in the endometrium that actively degranulated at homeostasis and was located in lymphoid

70 nt of bone marrow-derived neutrophils, which degranulate azurophilic granules to release the Ser prot

71 l retain some capacity to cross-link IgE and degranulate basophils, however, this capacity was dimini

72 A significant proportion of degranulated beta-cells remain, at the time of diagnosis

73 ease, are recovered beta-cells that had been degranulated but present at the time of diagnosis of dia

74 reatly decreased in mast cells stimulated to degranulate by IgE.

75 ion (IC(50) 8 nM) from human LAD2 mast cells degranulated by 100 nM C3a, and (c) selectivity for huma

76 ers of human dermal mast cells that could be degranulated by a number of secretagogues that activate

77 Substances degranulated by mast cells include serotonin, histamine,

78 rkable migratory, cytotoxic, phagocytic, and degranulating capacities gave rise to the traditional pe

79 Furthermore, the ability of NK cells to degranulate CD107a+ cytolytic vesicles was reduced (11%

80 memory cells, and most of the activated and degranulating (CD107a(+)) HDV-specific and total CD8(+)

81 trahepatic CD8(+) T cells, (ii) frequency of degranulating CD8(+) T cells with liver enzyme activity

82 well as the proportion of proliferating and degranulating CD8(+) T cells.

83 also augmented tumor-infiltrating CD107a(+)-degranulating CD8(+) T-cells (p<0.01) while dampening in

84 ranulation of mast cells, with the number of degranulated cells approaching levels observed in IgE- a

85 nted over 70% of all IFN-gamma-secreting and degranulating cells in the first 12-18 h after virus rec

86 When secreted from degranulating cells, it can interact with a variety of c

87 city of fluorochrome-labeled avidin to stain degranulating cells.

88 flow cytometric analyses of activated and/or degranulating cells.

89 mber and the percent of mast cells that were degranulated compared to that after ovariectomy alone, a

90 Degranulated CTLs are surface biotinylated by the cathep

91 biased manner and visualize them alone or in degranulating CTLs.

92 ace cathepsin B provides self-protection for degranulating cytotoxic lymphocytes.

93 Moreover, it had weak intrinsic degranulating effects on otherwise unstimulated Eo, prod

94 Without JNK1, mast cells fail to degranulate efficiently and release less IL-1beta after

95 ophil degranulation rate, number of duodenal degranulated eosinophil and mast cell between patients w

96 Moreover, the number of duodenal degranulated eosinophil in patients with FD were signifi

97 tor cells consisting of CD45RO+ T-cells, and degranulating eosinophils consistent with activation of

98 Degranulating eosinophils have been described in most en

99 We conclude that the abundant presence of degranulating eosinophils in the fibrous regions of endo

100 The presence of degranulating eosinophils was also associated with the p

101 plasmacytoma that is infiltrated by numerous degranulating eosinophils, would be especially sensitive

102 ression of activation markers, spontaneously degranulate ex vivo, and decrease expression of a signal

103 The characteristics of a partially purified degranulating factor isolated from conditioned supernata

104 dies indicated the presence of an additional degranulating factor not accounted for by IL-8.

105 t inflammatory cytokines induce synthesis of degranulating factors by human endothelial cells.

106 m conditioned supernatants demonstrated that degranulating factors distinct from IL8 are generated in

107 imulated with IL-1 release newly synthesized degranulating factors that require transcription and tra

108 Mast cells (MCs) similarly degranulate following Ag-dependent aggregation of the Fc

109 s profilin cleavage, which does not occur in degranulated HMC-1 mast cells, which are rich in tryptas

110 lly we present evidence that supernatants of degranulated human NK92 or primary NK cells also activat

111 on with CD4 T cells promoted accumulation of degranulated IL-4-expressing cells, but only if T cells

112 ey become phagocytically engorged, partially degranulated, immobilized, and rounded.

113 must adhere to the vessel wall, migrate, and degranulate in an ordered manner to perform their protec

114 but not the core of solid tumors, where they degranulate in close apposition to capillaries and epith

115 Although PCs failed to degranulate in infected B6 TLR9-/- mice, i.p. injection

116 e was a partial reduction in the capacity to degranulate in response to antigen, SCF was unable to en

117 d mIL-5Ralpha rendered these cells unable to degranulate in response to further IL-5 stimulation, but

118 In addition, gata2(hi) cells degranulate in response to helminth extract.

119 While their capacity to degranulate in response to IgE ligation in vivo was unim

120 rigin of fetal IgE and whether fetal MCs can degranulate in response to IgE-dependent activation are

121 r levels affect the ability of mast cells to degranulate in response to IgER cross-linking.

122 SPTs demonstrate that skin mast cells do not degranulate in response to IL-33.

123 dition to PAF and lysoPAF, human eosinophils degranulate in response to lysophosphatidylcholine, but

124 phils from PAFR(-/-) bone marrow progenitors degranulate in response to PAF and lysoPAF in a manner i

125 lls efficiently produce interferon-gamma and degranulate in response to stimulation with NK cell-susc

126 and that human peripheral blood eosinophils degranulate in response to the cell-free extract of A. a

127 sis factor alpha, as well as proliferate and degranulate in response to their cognate antigenic pepti

128 are fewer in number, less mature, and do not degranulate in response to wounding as effectively as ma

129 within a few hours if they are triggered to degranulate in the presence of nontoxic thiol cathepsin

130 r by their high affinity IgE receptors, they degranulated in a pattern similar to that of WT MCs.

131 These CD57(+)NKG2C(hi) NK cells degranulated in response to stimulation through their NK

132 ter 4 to 8 weeks of culture these mast cells degranulated in response to substance P and compound 48/

133 ization was enhanced greatly when HMC-1 were degranulated in the presence of HDMEC.

134 ctivated by immunostimulatory cytokines, and degranulated in the presence of NB cells.

135 Mast cells accumulated and degranulated in the skin of young Fgfr1-/Fgfr2-deficient

136 pothesized that in I/R, neurogenic ATP could degranulate juxtaposed MC and that ecto-nucleoside triph

137 8 that fail to produce effector cytokines or degranulate late postinfection, with minimally increased

138 Although ASK mast cells degranulated less vigorously than EL mast cells upon sti

139 NK cells and displayed superior capacity to degranulate lytic granules against KIR ligand-matched pr

140 ggest that application of compound 48/80, to degranulate mast cells, activates the adhesion of leukoc

141 Interleukin-1Ra reduced the number of degranulated mast cells and caused a significant reducti

142 L-4, and IL-13 expression and the absence of degranulated mast cells and less influx of eosinophils w

143 , and there was an increase in the number of degranulated mast cells in both lean subjects and subjec

144 However, degranulated mast cells in patients with FD were almost

145 Supernatant from degranulated mast cells increased [Ca2+]i in colonocytes

146 gand), mast cell tryptase, and a filtrate of degranulated mast cells stimulated a prompt increase in

147 Thrombin, trypsin, tryptase, a filtrate from degranulated mast cells, and peptides corresponding to t

148 the outer leaflet of the plasma membrane of degranulated mast cells.

149 ts and collagen fibers that were adjacent to degranulated mast cells.

150 arditis associated with increased numbers of degranulating mast cells (MCs) in the pericardium (26.6

151 challenged mouse tissues and discovered that degranulating mast cells (MCs) trap living neutrophils i

152 inflammatory responses via PAR-2 and whether degranulating mast cells induced synovial hyperemia by P

153 tudies with FITC-labeled avidin demonstrated degranulating mast cells only in ischemic samples of can

154 and humans frequently contain perivascular, degranulating mast cells that release heparin.

155 We observed that the number of degranulating mast cells was graded according to the Fce

156 Immunohistochemistry suggested that degranulating mast cells were the primary source of TNF-

157 protease released from secretory granules by degranulating mast cells, converts progelatinase B to an

158 bromas, which are composed of Schwann cells, degranulating mast cells, fibroblasts, and extracellular

159 ofibromas infiltrated with a high density of degranulating mast cells.

160 issue distribution of MC and the presence of degranulated MC in various (allergic) disorders, MC-deri

161 We found no evidence that 5-HT degranulates MC or modulates IgE-dependent activation.

162 ese tumors actively attract and subsequently degranulate MCs in the pleural space by elaborating CCL2

163 Here we show that the number of degranulated MCs is increased in unwounded forearm and f

164 of recent in vivo activation (CD69, CD107a), degranulated more efficiently than did control NK cells

165 On stimulation, such CTLs degranulated more readily than other T-cell subsets, but

166 peptides (HNPs) released from activated and degranulated neutrophils inhibit proteolytic cleavage of

167 Supernatant from degranulated neutrophils killed the pneumococcus, sugges

168 Digestion by supernatants of degranulated neutrophils was blocked by an inhibitor of

169 The digestion pattern of laminin-332 by degranulated neutrophils was nearly identical to that ge

170 killing by antimicrobial factors secreted by degranulated neutrophils, but does not affect intracellu

171 reus killing among other factors secreted by degranulated neutrophils.

172 Enzymes and other factors secreted by degranulating neutrophils (polymorphonuclear leukocytes,

173 acellular chromatin traps (NETs) produced by degranulating neutrophils.

174 pecifically CD16A-expressing Jurkat T cells, degranulated NK cells, induced cytokine production and k

175 Cell-free supernatants of degranulated normal and CGD neutrophils both suppressed

176 esent in infected lungs, and the neutrophils degranulated normally in response to K. pneumoniae infec

177 ing a repertoire of Ly49 family members that degranulated on stimulation ex vivo.

178 rsors secreted cytokines when stimulated and degranulated on target exposure.

179 ells shows that individual T cell clones can degranulate or degranulate and produce cytokine dependin

180 rize either cytoskeletal network and fail to degranulate or release DNA.

181 Furthermore, dNK were unable to degranulate or secrete cytokines in response to HCMV-inf

182 These cells degranulated or secreted IFN-gamma, but not both, when i

183 Degranulated, P-selectin-positive platelets, however, ag

184 ybdotoxin (100 to 500 nmol/L), and mast cell degranulating peptide (1 micromol/L).

185 lated with Mastoparan 7 (M7-NH(2)) mast cell degranulating peptide adjuvant and administered intranas

186 of HBV peptides, such as secapin, mast cell degranulating peptide, and melittin (Api m 4) were detec

187 ive peptide toxins dendrotoxin and mast cell degranulating peptide.

188 at is sensitive to dendrotoxin and mast cell degranulating peptide.

189 esions for neutrophil elastase revealed many degranulating perivascular neutrophils, with no equivale

190 ytopenia-induced tumor bleeding, circulating degranulated platelets did not.

191 In summary, (i) circulating degranulated platelets rapidly lose surface P-selectin t

192 mpared the ability of transfused resting and degranulated platelets to prevent intratumor hemorrhage.

193 for the first time in vivo that (1) infused degranulated platelets very rapidly form circulating agg

194 Circulating degranulated platelets were increased in patients with C

195 ls, and (2) 30 minutes after infusion of the degranulated platelets, the percentage of circulating mo

196 acid that is at least partially derived from degranulating platelets.

197 hypothesis that surface P-selectin-positive (degranulated) platelets are rapidly cleared from the cir

198 There was no loss of total MCs, partially degranulated plus intact, during the 4 h of observation.

199 s of active serine proteinases released from degranulating PMN.

200 metalloproteinase (MMP)-8 and -9 released by degranulating polymorphonuclear cells (PMNs) promote per

201 ss high levels of inflammatory cytokines but degranulate poorly.

202 t in NLRP3 or ASC did not form granulosomes, degranulated poorly in vitro and did not evoke systemic

203 nulocyte-macrophage CSF, and enhanced the Eo-degranulating potencies of PAF, C5a, LTB4, and FMLP by u

204 However, CD8(+) dT degranulated, proliferated, and produced IFN-gamma, TNF-

205 Once within the brain, neutrophils degranulate, releasing destructive molecules that may ex

206 ted by recruitment of neutrophils, which can degranulate, releasing powerful proteinases responsible

207 LPS also induced the release of degranulating signals for PMNs from a human endothelial

208 e to LPS or other pathologic agonists, these degranulating signals may activate PMNs in combination o

209 MVA-043 peptide-stimulated lymph node cells degranulated similarly as assessed by Ag-induced CD107 e

210 t SHIV-immunized animals, polyfunctional and degranulating SIV-specific CD8(+) T cells were present i

211 Collectively, codeine degranulates skin mast cells through MRGPRX2, at which i

212 tization and challenge, are activated by and degranulate specifically in response to PVM infection.

213 o augmented response to chemoattractants and degranulating stimuli is a characteristic feature of eos

214 ficient mast cells we show that they fail to degranulate, synthesize leukotrienes and secrete cytokin

215 t more of them secrete IFN-gamma and readily degranulate than non-ThCTL.

216 MCT in the ES stroma were more degranulated than in those with PS (median degranulation

217 ther T-cell subsets, but had a propensity to degranulate that was similar to NK cells.

218 However, when neutrophils degranulate, these proteinases are released and can caus

219 When activated to degranulate, they release a plethora of bioactive compou

220 -associated vasculitis (AAV) show mast cells degranulate, thus enhancing injury as well as producing

221 In wounds and fibrotic lesions, mast cells degranulate to release tryptase, and thrombin mediates b

222 5AC revealed a significantly higher ratio of degranulated to nondegranulated GCs after the ITN (IB: 2

223 hough control subjects had a higher ratio of degranulated to nondegranulated GCs at baseline (0.75 +/

224 The ratio of degranulated to nondegranulated GCs was measured as a ma

225 is, unevenly distributed across granules and degranulated upon activation.

226 competently produced effector cytokines and degranulated upon Ag reencounter.

227 produced very large amounts of IFN-gamma and degranulated upon TCR activation.

228 s and RBL-2H3 cells, a mast cell model which degranulates upon cross-linking of the high-affinity imm

229 te that MCs react to vaccinia virus (VV) and degranulate using a membrane-activated pathway that lead

230 se subsets display a cytotoxic phenotype and degranulate when challenged with primary acute myeloid a

231 Isolated myocytes also degranulated when incubated with oxytocin (P<0.0001), bu

232 ted neutrophils adhere to the SCD fibers and degranulate with release of the constituents of their ex