ライフサイエンスコーパス: degranulation

1 flux, and beta-hexosaminidase release (i.e., degranulation).

2 anulation but also essential to achieve full degranulation.

3 ntified regulators of tumor infiltration and degranulation.

4 peptide epitope triggered KIR2DS4(+) NK cell degranulation.

5 duced reactive oxygen species production and degranulation.

6 n, interferon-gamma production, and CD107a/b degranulation.

7 2 leptospiral proteins as able to induce HBP degranulation.

8 tified mast cell recruitment into SC WAT and degranulation.

9 lux and concentration-dependent induction of degranulation.

10 MCG fate after skin inflammation-induced MC degranulation.

11 er the ability of SP-A to inhibit eosinophil degranulation.

12 dysfunction, allergic sensitization, and MC degranulation.

13 rization toward neighboring NK cells without degranulation.

14 RPV4-mediated Ca(++)-influx evokes mast cell degranulation.

15 in, led to an important decrease of basophil degranulation.

16 ysicochemical properties influence mast cell degranulation.

17 eature of CSU, which could enhance mast cell degranulation.

18 previously unappreciated intrinsic defect in degranulation.

19 leukin-2 production and CD107(a/b) cytotoxic degranulation.

20 identify genes that regulate human mast cell degranulation.

21 tin reduction at the immune synapse precedes degranulation.

22 ctivation with IL-3 on IgG-driven eosinophil degranulation.

23 mast cells was not correlated with mast cell degranulation.

24 ular activation and natural killer (NK) cell degranulation.

25 TRPV4 loss of function attenuates mast cell degranulation.

26 tion and survival, and suppressing mast cell degranulation.

27 r of CD32- and alphaMss2-mediated eosinophil degranulation.

28 actin acts as a barrier preventing sustained degranulation.

29 eases associated with IgE-mediated mast cell degranulation.

30 s were also dysfunctional and showed reduced degranulation.

31 te early immune events that impact mast cell degranulation.

32 lator (ITN) on conjunctival goblet cell (GC) degranulation.

33 ng proteins involved in cytotoxic lymphocyte degranulation.

34 le-dependent movement of SGs required for MC degranulation.

35 but decreased NK cell cytolytic activity and degranulation.

36 he calcium response that is essential for MC degranulation.

37 tion, and inhibited Phl p 5-induced basophil degranulation.

38 face CD107a expression, indicating cytotoxic degranulation.

39 d sensitized fetal MCs for allergen-specific degranulation.

40 neumococci are potent inducers of neutrophil degranulation.

41 tential immunosuppressive role of neutrophil degranulation.

42 ffectors are required to effectively inhibit degranulation.

43 reated CD4(+) T cell condition induced clone degranulation.

44 d towards cytotoxicity with increased CD107a-degranulation (10.1% vs 14.6%; P=0.0263) and reduced cap

45 Platelet degranulation, a form of regulated exocytosis, is crucia

46 oduction and at least a transiently impaired degranulation ability.

47 drial DNA release, chemotaxis, phagocytosis, degranulation, ability to harm the endothelium, and resp

48 STAT1 phosphorylation, markers of neutrophil degranulation, activation and NET release were found in

49 ws a significant impairment of cytolytic and degranulation activities in patients with STAT1 GOF muta

50 P. falciparum-infected RBCs induced NK cell degranulation after addition of plasma from malaria-resi

51 were co-cultured with SCFAs and assessed for degranulation after IgE- or non-IgE-mediated stimulation

52 ld to activation and increased the extent of degranulation along with the percentage of mast cells re

53 epletion of MCs granules or prevention of MC degranulation also reduced DVT.

54 by PCR, STAT1 phosphorylation and markers of degranulation and activation by flow cytometry.

55 ialic acid from IgE attenuates effector-cell degranulation and anaphylaxis in several functional mode

56 re-challenge reactions leading to mast cell degranulation and anaphylaxis is unclear.

57 concentrations, they may cause fulminant MC degranulation and anaphylaxis.

58 (CRF(2)) as a modulator of stress-induced MC degranulation and associated disease pathophysiology.

59 stinguished cases; one enriched for platelet degranulation and blood coagulation pathways and the oth

60 onditions demonstrated increased nondirected degranulation and bystander killing.

61 he presence of CCL7 synergistically enhanced degranulation and calcium influx.

62 8 T cells showed significantly less in vitro degranulation and CD4 killing capacity than blood CD8 T

63 es, perforin and granzyme beta, with reduced degranulation and CD57 expression and, consistently, mar

64 strated MRGPRX2 upregulation associated with degranulation and CD63 expression.

65 was enriched in genes related to neutrophil degranulation and cell cycle regulation.

66 sessed major neutrophil functions, including degranulation and cell migration, associated with the p3

67 bation of PGT151 and primary NK cells led to degranulation and cellular death.

68 t also the magnitude of individual mast cell degranulation and chemokine production.

69 Standard degranulation and chromium release cytotoxicity assays c

70 BV(+) individuals triggered vigorous NK cell degranulation and cytokine production (i.e., TNF-alpha a

71 ersible BTKis broadly prevented IgE-mediated degranulation and cytokine production in primary human m

72 ation, as shown by a significant increase in degranulation and cytokine production when basophils are

73 K cells reduces target-specific Ca(2+)-flux, degranulation and cytokine production.

74 ggers multiple cellular responses, including degranulation and cytokine production.

75 d in well-known activating functions such as degranulation and cytoskeletal reorganization, but also

76 NK cells cocultured with M2 displayed lower degranulation and cytotoxic activity than NK cells cocul

77 poresponsive CD56(dim) NK cells with limited degranulation and cytotoxic capacity.

78 atory cytokine production, without effecting degranulation and cytotoxic function.

79 polymerize actin and exhibit a block in both degranulation and DNA release.

80 sfully interferes with allergen-induced cell degranulation and efficiently inhibits systemic anaphyla

81 ned that norepinephrine stimulated mast cell degranulation and histamine release in vitro.

82 or effects on FcepsilonRI-mediated mast cell degranulation and identified 15 potential regulators.

83 We analyzed NK cell degranulation and IFNgamma-response along with STAT-1 an

84 Mechanistically, IgE-mediated degranulation and IL-6 production from C5ar1(-/-) BMMCs

85 ect and redirected polyfunctionality assays (degranulation and intracellular production of TNF-alpha

86 vation, requires elevated ROS production and degranulation and involves EET formation.

87 d with neutrophil influx into the airway and degranulation and is marked by overexpression of protein

88 ative global modulator of stimuli-induced MC degranulation and limits the severity of IgE-mediated an

89 oth human GA and a rat model for GA, that MC degranulation and MC-derived tryptase are central to dis

90 yeloperoxidase inhibition reduced neutrophil degranulation and neutrophil-mediated endothelial cell d

91 gous and allogeneic natural killer (NK)-cell degranulation and NK-cell-mediated antibody-dependent ce

92 Neutrophils of Akita/Ncf1 mice had normal degranulation and phagocytic efficiency when compared wi

93 ese mice displayed a reduction in neutrophil degranulation and preserved cardiac function.

94 nleash numerous attacks on pathogens through degranulation and reactive oxygen species (ROS) producti

95 mpaired ability to re-express perforin after degranulation and reduced cytotoxic immune function.

96 treated with omeprazole exhibited diminished degranulation and release of cytokines and histamine in

97 lls initiates activation events that lead to degranulation and release of inflammatory mediators.

98 silonRI on effector cells, resulting in cell degranulation and release of proinflammatory mediators.

99 ity receptor (FcepsilonRI) induces mast cell degranulation and subsequent symptom development.

100 stander B cells trigger Ab-dependent NK cell degranulation and TNF-alpha but not cytotoxicity or IFN-

101 also promoted specific Ab-dependent NK cell degranulation and TNF-alpha production but induced minim

102 th dendritic cells (DCs), MC activation, and degranulation and tracked the fate of exocytosed mast ce

103 proteases) and reduced mediator release upon degranulation, and 4) engraftment of MC-deficient Kit (W

104 binding to Cyp c 1, Cyp c 1-induced basophil degranulation, and allergic symptoms caused by allergen

105 of gamma interferon (IFN-gamma), CD107(a/b) degranulation, and CD4(+) T cell carboxyfluorescein succ

106 ced eosinophil IL-1beta and IL-18 secretion, degranulation, and cell death.

107 nition of Cyp c 1, Cyp c 1-specific basophil degranulation, and Cyp c 1-induced allergic symptoms in

108 gainst CD11b significantly reduced adhesion, degranulation, and fibrinogenolysis.

109 ed reactive oxygen species production, early degranulation, and granule fusion processes, leading to

110 ific IgE production, FcepsilonR1-mediated MC degranulation, and histamine-driven effector functions p

111 each anti-SEE mediated SEE-induced basophil degranulation, and IgG1 or antigen-binding fragments of

112 ive capability in response to cytokines, low degranulation, and impaired cytokine production on inter

113 t NK cells, altered IFN-gamma production and degranulation, and impairment of NK cell proliferation i

114 H33-CD8BBZ exhibit similar cytokine release, degranulation, and mouse tumor eradication as a CAR that

115 , NK cell phenotype, perforin expression and degranulation, and natural or antibody-dependent cell cy

116 Reactive oxygen species (ROS) production, degranulation, and phagocytosis are normal in the absenc

117 cient in antigen-stimulated calcium release, degranulation, and production of some cytokines (TNF-a,

118 r NK cell development, IFN-gamma production, degranulation, and proliferation in Klf12 knockout mice.

119 antly increased interferon gamma production, degranulation, and specific killing against NK-resistant

120 osinophil apoptosis, inhibition of mast cell degranulation, and suppression of inflammation.

121 anced cytokine secretion, polyfunctionality, degranulation, and the cytotoxic potential of NK cells f

122 ction and responded by activation, piecemeal degranulation, and upregulation of Ag presentation marke

123 circulating IgE, which can induce mast cell degranulation, as well as Mcpt-1 and Mcpt-4, were observ

124 unctional activity, fluorescent avidin-based degranulation assay, calcium mobilization, cytokine prod

125 Lysosomal-associated membrane protein 1 degranulation assays and human basophil activation tests

126 molecules was assessed in different cellular degranulation assays ex vivo and in a mouse model of pas

127 uated via ELISA to measure cHBI-IgE binding, degranulation assays of rat basophil leukemia cells for

128 t Ab and inhibited degranulation in cellular degranulation assays using rat basophil leukemia cells.

129 In vitro MC degranulation assays were performed with bone marrow-der

130 of Der p 13 were examined by ELISA, basophil degranulation assays, and in vitro airway epithelial cel

131 cted sputum ANCA was assessed using in vitro degranulation assays.

132 IgE activities were tested in basophil degranulation assays.

133 questering proteins as well as a decrease in degranulation-associated proteins.

134 nity anti-IgE mAbs that trigger anaphylactic degranulation at low concentration.

135 -derived NK cells, harbor a potent cytotoxic degranulation bias.

136 ytosis is not only required to accelerate MC degranulation but also essential to achieve full degranu

137 d with histological evidence of defective MC degranulation but not with changes in MC development, di

138 Successful DAA-therapy did not affect CD107a-degranulation, but decreased STAT-1.

139 ophils does not affect granule morphology or degranulation, but it causes LAMP1(+) lysosomes to engor

140 stantial inhibition of HDP-induced mast cell degranulation, but PgLPS1435/1449 had no effect.

141 n, we found that production of IFN-gamma and degranulation by CD56(bright) and CD56(dim) NK cells fol

142 ast cells susceptible to vibration-triggered degranulation by cleaving the alpha subunit of the EGF-l

143 Degranulation by codeine was attenuated by stem cell fac

144 erential regulation of HDP-induced mast cell degranulation by PgLPS1690 and PgLPS1435/1449 may contri

145 -binding fragments of each anti-SEE enhanced degranulation by the other anti-SEE.

146 veloped an imaging system in which mast cell degranulation can be visualized in single cells subjecte

147 Immunoglobulins (Ig)-binding and the degranulation capacities of native and aggregated ovalbu

148 rom anti-NKG2D-treated mice showed defective degranulation capacities toward autologous activated imm

149 Perforin/granzyme B content, degranulation (CD107a expression), and cytotoxicity agai

150 ion (HLA-DR(+) CD38(+)), cycling (Ki-67(+)), degranulation (CD107a(+)), and the immune checkpoint pro

151 icantly up-regulated the marker of cytotoxic degranulation (CD107a) on CD8(+) T cells (P = 0.03) from

152 Furthermore, NK cell activation, degranulation, chemokine/cytokine production, and Ab-dep

153 tial responders of innate immunity and their degranulation contribute to various etiologies.

154 on induced by HDP/MRGPRX2-mediated mast cell degranulation contributes to gingival homeostasis but th

155 and their functional characterization using degranulation, cytokine production, and proliferation as

156 Mast cell degranulation, cytokine secretion, and early signaling e

157 improved multiple CD56bright cell functions: degranulation, cytotoxicity, and cytokine production.

158 duction in an NFAT-dependent manner, NK cell degranulation/cytotoxicity and tumor rejection in vivo r

159 hicine to Def(++) mice to inhibit neutrophil degranulation decreased plasma levels of alpha-defs, cau

160 AP3 complex formation and the degranulation defect in patient T cells were restored by

161 Although degranulation depends crucially on microtubule dynamics,

162 hairs showed a similar abrupt transition of degranulation/depolarization near sites of keratin depos

163 ionic RNases during both differentiation and degranulation, enabling their intracellular packaging an

164 ce-bound IgE without triggering anaphylactic degranulation even at high concentration, albeit they wo

165 ergic sensitization, and allergen-induced MC degranulation even in the absence of inflammatory enviro

166 een these identified pathways and changes in degranulation (exocytosis) and adhesion were analysed.

167 e marrow-derived mast cells showed decreased degranulation following IgE and Ag treatment compared wi

168 nd non-IgE-mediated human or mouse mast cell degranulation in a concentration-dependent manner.

169 Furthermore, HDPs stimulated degranulation in a human mast cell line (LAD2) and in RB

170 vivo and further primed human mast cells for degranulation in an antigen-independent fashion.

171 ve oxygen species production, and neutrophil degranulation in ANCA-stimulated neutrophils in the abse

172 specifically to its target Ab and inhibited degranulation in cellular degranulation assays using rat

173 nown about the significance of MCs and their degranulation in choroid.

174 lucan (a DECTIN-1 agonist) induced mast cell degranulation in mesenteric windows and HMC-1 cells resp

175 he production of reactive oxygen species and degranulation in neutrophils.

176 Hyporesponsiveness to degranulation in NK cells was not restored at least for

177 We monitored mast cell degranulation in real time by exploiting the capacity of

178 effect on cell surface MRGPRX2 expression or degranulation in response to compound 48/80 or AG-30/5C.

179 with a significant decrease in subsequent MC degranulation in response to compound 48/80 or AG-30/5C.

180 nhibited compound 48/80-induced Tango and MC degranulation in response to compound 48/80, AG-30/5C, a

181 ike their adult counterparts, exhibit robust degranulation in response to stimulation.

182 l recruitment in lean subjects and mast cell degranulation in SC WAT of all research participants ind

183 Heparin released during mast cell degranulation in the gastrointestinal tract might libera

184 ented all of GA-like phenotypes following MC degranulation in the rat model.

185 inal cord and plasma and decreased mast cell degranulation in the tibialis anterior muscle of transge

186 sputum immunoglobulins to induce eosinophil degranulation in vitro was assessed.

187 sed autoantibody levels triggered eosinophil degranulation in vitro, with release of extensive histon

188 he alteration of functional responses, i.e., degranulation, in single human mast cells (10-12 weeks o

189 tissues after CLE challenge, but eosinophil degranulation increased, and levels of eosinophilic cati

190 eosinophils, shock (hypothermia), mast cell degranulation (increased serum mouse mast cell protease

191 Conversely, postwounding MC degranulation increases in nondiabetic mice, but not in

192 Consequently, MC degranulation increases surface delivery of HLA class II

193 et al. report that DENV can cause mast cell degranulation independently of mast cell infection, resu

194 LE(+) patients also had increased eosinophil degranulation, indicating an atypical food allergy chara

195 store-operated Ca(2+) entry signaling and MC degranulation induced by diverse MC stimuli.

196 , production of reactive oxygen species, and degranulation induced by immobilized immune complexes, w

197 Degranulation induced by vibration was dependent on phos

198 1, which proved to be an effective mast cell degranulation inhibitor in vitro and can be delivered to

199 r depletion of eosinophils or treatment with degranulation inhibitors.

200 tion to cytokine production, acute mast cell degranulation is a critical component of allergic respon

201 We report that degranulation is linked to the number of FcepsilonRI occ

202 Intriguingly, whereas degranulation is MALT1-independent, MALT1(PD/PD) mice ar

203 that while ICH induced mast cell activation/degranulation, IVIG attenuated post-ICH mast cell activa

204 n this article, we show that IgE-mediated MC degranulation leads to a rapid release of high quantitie

205 eutrophil functions, including phagocytosis, degranulation, leukotriene, and reactive oxygen species

206 ture phenotype and impaired cytotoxicity and degranulation, levels of memory B cells were reduced, an

207 olysis was not required directly for NK cell degranulation, limiting the rate of glycolysis significa

208 tion of CD8(+) T cells expressing the CD107a degranulation marker in the absence of IFNgamma, TNFalph

209 ature granulocytes expressing high levels of degranulation markers, were specifically responsible for

210 articularly in neonates, and that subsequent degranulation may contribute to common lung, eye, and br

211 V infection, while the loss of CD8(+) T cell degranulation may impede the proper killing of infected

212 We also measured mast cell degranulation (MCD)72 h post-injury.

213 stimulated neutrophils through a controlled degranulation mechanism.

214 use of the BAT necessitates knowledge about degranulation metrics and guidance to guarantee correct

215 ause a single CTL can kill multiple targets, degranulation must be tightly regulated.

216 ce-bound neutrophil elastase (NE) during PMN degranulation, NE being oriented in a configuration resi

217 gand superfamily member 14; sparse mast cell degranulation; numerous forkhead box protein P3 (FoxP3)+

218 While allergic mast cell (MC) degranulation occurs by FcepsilonRI aggregation and vari

219 For pistachio, the degranulation of basophils after challenge with the hars

220 IL-33 significantly enhanced IgE-mediated degranulation of BMMCs in vitro.

221 pe I hypersensitivity diseases by activating degranulation of effector cells such as mast cells and b

222 continuing exposure to IL-3 further induced degranulation of eosinophils on aggregated IgG via incre

223 This was supported by the constant degranulation of Gal-9(+) T cells.

224 document that the Allergan ITN can stimulate degranulation of goblet cells in the conjunctiva, which

225 EP4 agonism also curbed FcepsilonRI-mediated degranulation of human MCs.

226 We show that free Fel d 1 induces degranulation of IgE-sensitized mast cells whereas Fel d

227 vation, as well as IgE- and calcium-mediated degranulation of LAD-2 cells, in a dose-dependent manner

228 nisms are conventionally known to facilitate degranulation of mast cells and basophils and promote TH

229 Degranulation of mast cells and basophils, with release

230 esponse to dermal vibration, with coincident degranulation of mast cells and increased histamine leve

231 f allergic skin inflammation by inducing the degranulation of mast cells contiguous to such nocicepto

232 reduced itching caused by wasp venom peptide degranulation of mast cells in mice by 51% (P < 0.05), w

233 DH is essential for immunologically mediated degranulation of mast cells.

234 reduced toward holoBLG, which also impaired degranulation of mast cells.

235 ents or by genetic manipulation prevents the degranulation of neutrophils and mitochondrial DNA relea

236 ll defined role in innate immunity, aberrant degranulation of neutrophils in several inflammatory dis

237 Ent also impaired the degranulation of primary granules and inhibited phagocyt

238 , were hypoallergenic as they hardly induced degranulation of rat basophil leukemia cells sensitized

239 ll (MC) IgE receptors (FcepsilonRI) triggers degranulation of secretory granules (SGs) and the releas

240 in vitro studies revealed no differences in degranulation or mediator release between WT and Fn14(-/

241 leased in response to cell lysis, apoptosis, degranulation, or membrane pore formation.

242 matrix organization, platelet activation and degranulation, or post-translational protein phosphoryla

243 oxygen species (ROS) production (P = 0.002), degranulation (P < 0.0001) or eosinophil extracellular t

244 c and neutrophil infiltration and mast cells degranulation (p < 0.05).

245 age colony-stimulating factor) and cytolytic degranulation pathway effectors (eg, perforin/granzyme).

246 i-inflammatory IL-1RA and reduced neutrophil degranulation, phagocytosis, and NETosis.

247 line granzyme B (P = .0068; R(2) = 0.29) and degranulation potential (P = .022; R(2) = 0.22) in stimu

248 Pharmacological block of mast cell degranulation potently inhibited histamine release by ma

249 The degranulation process is monitored by using either time-

250 During the degranulation process, the granule matrix is externalize

251 HIV peptide stimulation increased CD8 T cell degranulation, production of intracellular cytokines, an

252 nd enables the parallel visualization of the degranulation profiles of both edited and non-edited mas

253 We investigated the role of adhesion- and degranulation-promoting adapter protein (ADAP) in promot

254 ion, Western blot, confocal microscopy, cell degranulation, prostaglandin D(2) secretion, and proteas

255 Consistent with the immaturity of GF MCs, degranulation-provoking compound 48/80 induced less edem

256 ctors JFC1 and Munc13-4 in the regulation of degranulation, reactive oxygen species and neutrophil ex

257 eutrophil viability, and in combination with degranulation, reactive oxygen species production and in

258 1-specific T cells rapidly undergo cytotoxic degranulation, release granzyme B and pro-inflammatory c

259 1-specific T cells rapidly undergo cytotoxic degranulation, release granzyme B and proinflammatory cy

260 hereas the magnitude of individual mast cell degranulation remained unchanged, suggesting an all-or-n

261 on allergic sensitization and mast cell (MC) degranulation remains speculative.

262 gE, mast cell and basophil sensitisation and degranulation, requiring a range of medications to manag

263 d by fluorescence-activated cell sorting and degranulation, respectively.

264 rise to NK cells that exhibit an attenuated degranulation response but robustly produce inflammatory

265 ing: 1) term pregnancy dNK have an increased degranulation response to K562 and PMA/ionomycin but low

266 releasing factor (CRF) system potentiates MC degranulation responses during IgE-mediated anaphylaxis

267 mically distinct ENMs caused a range of mast degranulation responses, with smaller sized Ag NPs (5 nm

268 strong heterogeneity of individual mast cell degranulation responses.

269 The infiltration and degranulation screens converged on an RNA helicase Dhx37

270 ch as through Toll-like receptor 2-triggered degranulation, secretion of antimicrobial cathelicidins,

271 dium cromoglycate blocks injurious mast cell degranulation specifically without affecting the immunom

272 il CD63 induction indicative of anaphylactic degranulation; suppress peanut-, cat-, and dansyl-specif

273 ed; mean perforin expression was normal; and degranulation tests and NK cell cytotoxicity were not di

274 friction of the skin induces mast cell hyper-degranulation through p.C492Y-ADGRE2, causing localized

275 s Mrgprb2 and FcepsilonRI-mediated mast cell degranulation to attenuate pseudo-allergy and anaphylaxi

276 Conversely, degranulation triggered by compound 48/80 is highly corr

277 Icatibant caused MC degranulation via a pertussis toxin-sensitive G protein

278 lls, we demonstrate that AG-30/5C induces MC degranulation via Mas-related G protein-coupled receptor

279 ykinin B(2) receptor antagonist, promotes MC degranulation via MRGPRX2 and causes pseudoallergic drug

280 nd compound 48/80 induced similar maximal MC degranulation via MRGPRX2, which was abolished by pertus

281 fect of Siglec-7 on eosinophil viability and degranulation was assessed in vitro by AnnexinV-FITC/7-A

282 vo, mast cell-mediated histamine release and degranulation was augmented upon TPC1 inhibition, althou

283 Cytolytic degranulation was defined by loss of membrane integrity,

284 Maximal degranulation was elicited when approximately 2700 IgE-F

285 Degranulation was enhanced upon suboptimal neutrophil ac

286 cell activation was higher and CD8(+) T cell degranulation was lower.

287 Independent from degranulation, we also show that multiple Yop effectors

288 d mast cells, but there was no difference in degranulation when cells were activated via an IgE-indep

289 ed to stimulate high levels of effector cell degranulation when using the humanized RBL-SX38 cell mod

290 nic entities released on frequent eosinophil degranulation, which further contributes to disease seve

291 es Mrgprb2 and MRGPRX2, triggering mast cell degranulation, which inhibits bacterial growth and preve

292 excellence potently inhibits pseudo-allergic degranulation, while it simultaneously promotes allergic

293 time in the gingival tissue, and subsequent degranulation will contribute to tissue damage.

294 a specific trigger for cytolytic eosinophil degranulation with implications in human disease.

295 s, pharmacological intervention targeting MC degranulation with ketotifen fumarate or inhibition of M

296 latelet-derived serotonin induced neutrophil degranulation with release of myeloperoxidase and hydrog

297 hi o 2 displayed IgE-reactivity and basophil degranulation with sera from all cyclophilin-positive pa

298 Blocking neutrophil degranulation with TAT-SNAP23 fusion protein significant

299 ophil activation (within 1 h) and neutrophil degranulation, with significantly greater cellular expre

300 termed "cytokinergic", of inducing basophil degranulation without the intervention of an antigen.