ライフサイエンスコーパス: dehalogenation

1 ments, methyl-group transfers, and reductive dehalogenation.

2 is an active oxidant in halophenol oxidative dehalogenation.

3 ons also result in a decrease in the rate of dehalogenation.

4 from our model system to microbial reductive dehalogenation.

5 atalysis is triggered by substrate reductive dehalogenation.

6 biodegradation and zerovalent metal-mediated dehalogenation.

7 electron transfer as start of the reductive dehalogenation.

8 azoles, as a result of reduced propensity to dehalogenation.

9 ned catalytic mechanism for Chd-mediated TPN dehalogenation.

10 function as a proton donor during reductive dehalogenation.

11 ironments often build on microbial reductive dehalogenation.

12 d through haloglycosylation and a subsequent dehalogenation.

13 ross-coupling reactions as well as reductive dehalogenations.

14 at the core was designed to prevent in vivo dehalogenation, a potential problem for radiohalogens in

15 The dehalogenation ability of wild-type Mb is augmented in t

16 Finally, only minimal differences in dehalogenation activities are seen among the exogenous l

17 Dehalogenation activity and cell growth were maintained

18 The hexachloroethane dehalogenation activity of CYP101 has been investigated

19 lue native gel electrophoresis together with dehalogenation activity tests and mass spectrometry.

20 zed and because of known problems with quick dehalogenation after internalization of antibodies, we d

21 ions (beta-alkylation, beta-aminoalkylation, dehalogenation, amine arylation, and decarboxylative rad

22 imization enabling control of unwanted proto-dehalogenation and alkene reduction side products.

23 n transfer, was utilized for photo-catalyzed dehalogenation and borylation.

24 Despite the number of methods available for dehalogenation and carbon-carbon bond formation using ar

25 hus leading to simultaneous enantioselective dehalogenation and deamination to form the corresponding

26 t in most of the reported conditions used in dehalogenation and deoxygenation processes.

27 heir relative thermodynamic stability toward dehalogenation and how different substitution patterns g

28 and overall transformations involved in the dehalogenation and isomerization reactions are strikingl

29 ide degradation is the rate-limiting step to dehalogenation and mineralization of the lampricide.

30 cross-coupling reactions, such as reductive dehalogenation and Suzuki-Miyaura reactions.

31 fundamental knowledge of microbial reductive dehalogenation and warrant further studies on the enrich

32 in our understanding of bacterial reductive dehalogenation and, thereby, provides important informat

33 lytic isomerization reactions, which include dehalogenation and/or hydrodgenation of benzophenone sub

34 found that EREDs can also catalyse reductive dehalogenations and cyclizations via single electron tra

35 d (aerobic C-Cl bond cleavage via hydrolytic dehalogenation), and -57 +/- 3 per thousand and -77 +/-

36 on), 0.7 +/- 0.1 and 0.9 +/- 0.1 (hydrolytic dehalogenation), and 1.76 +/- 0.05 and 3.5 +/- 0.1 (diha

37 otope fractionation was smaller in enzymatic dehalogenation, and dual-element isotope slopes (2.2-2.8

38 nt role in both hexachloroethane binding and dehalogenation, and hexachloroethane binding and dehalog

39 Enzymatic reactions, such as isomerisation, dehalogenation, and methyl transfer, rely on the formati

40 ated cyclizations to C-C bond constructions, dehalogenations, and H-atom abstractions.

41 Microbial reductive dehalogenation at contaminated sites can produce nontoxi

42 active mutant for hexachloroethane reductive dehalogenation at pH 7.4 was F87W-V247L (80 min-1 or 2.5

43 aid in understanding the bacterial reductive dehalogenation at the molecular level.

44 O reduction at the Cu2O surface, followed by dehalogenation at the Pd using the in situ generated H2.

45 populations might contribute to the observed dehalogenation based on their growth during incubation a

46 Inhibition of dehalogenation by chloroform is often seen in Dehalococc

47 and/or kinetic differences in catalytic PCE dehalogenation by enzymes and different corrinoids, wher

48 In this study, carbon tetrachloride (CT) dehalogenation by the chloride form of GR (GRCl) was tes

49 oethane binding while increasing the rate of dehalogenation by up to 40% at pH 6.5, suggesting that t

50 aqueous alkaline solution (pH 8); reductive dehalogenation by zero-valent iron nanoparticles (nZVI)

51 e critical role of semiquinones in reductive dehalogenation can be relevant to a wide range of quinon

52 al for horizontal dissemination of reductive dehalogenation capabilities within microbial populations

53 In this study, we examined the dehalogenation capability of each strain to use chlorobe

54 role of the corrinoid cofactor in reductive dehalogenation catalysis by tetrachloroethene reductive

55 o examine whether the mechanism of oxidative dehalogenation catalyzed by C. fumago chloroperoxidase (

56 Furthermore, the initial rate of dehalogenation catalyzed by Mb Cpd II is nearly comparab

57 The dehalogenation chemistry is specific to 1-fluorooctane,

58 A (CoA) were required to stimulate reductive dehalogenation, consistent with the intermediacy of 2-ch

59 monooxygenase catalyzing hydroxylation plus dehalogenation/denitration, which is useful for biodetox

60 in the context of electro-organic synthesis (dehalogenation, deoxygenation) of pharmaceutically relev

61 able to demanding photoreductions, including dehalogenations, detosylations, and the degradation of a

62 e and mechanism of nature's halogenation and dehalogenation enzymatic strategies, highlights gaps in

63 ecause the accumulated evidence for cis-CaaD dehalogenation favored a mechanism involving direct subs

64 actions were due to methyltransferase driven dehalogenation, followed by methylation.

65 ed into 2-iodo serinyl glycosides which upon dehalogenation gave C-2 deoxy amino acid glycoconjugates

66 Specifically, mechanisms of hydroxylation, dehalogenation, halogenation, and light-emitting reactio

67 However, underlying mechanisms of reductive dehalogenation have remained uncertain.

68 bond cleavage, acceptorless dehydrogenation, dehalogenation/hydrogen transfer, oxidation and reductio

69 inium salts can only continue to perform the dehalogenation if there is residue water remaining from

70 g pharmaceuticals from associated isomers or dehalogenation impurities can sometimes be quite difficu

71 This study addressed dehalogenation in actual microorganisms and observed ide

72 was investigated during anaerobic reductive dehalogenation in methanogenic laboratory microcosms.

73 dehalogenases are responsible for biological dehalogenation in organohalide respiring bacteria, with

74 This unique selectivity allows benzylic dehalogenation in the presence of aryl and alkyl halides

75 ta-BDEs or PCE, suggesting that co-metabolic dehalogenation initiated by multifunctional RDases may c

76 hanism of DHP-catalyzed oxidative halophenol dehalogenation involves two consecutive one-electron ste

77 Dehalogenation is a critical transformation in chemical

78 Mb Cpd II is an active oxidant in halophenol dehalogenation is consistent with a traditional peroxida

79 ggest that halide expulsion during reductive dehalogenation is initiated through single electron tran

80 Although reductive dehalogenation is key to their environmental and enginee

81 Reductive dehalogenation is not typical of aerobic organisms but p

82 The activation of the coupling by initial dehalogenation is tracked by monitoring Br 3d core level

83 Such a reductive dehalogenation is uncommon in aerobic organisms, and its

84 Although microbial reductive dehalogenation is well known for the other organohalides

85 We report bioreactor performance and dehalogenation kinetics of a D. mccartyi-containing cons

86 2-2.8) were distinctly different compared to dehalogenation mediated by corrinoids (4.6-7.0).

87 ples is presented including decarboxylation, dehalogenation, nucleophilic addition, dimerisation, oxi

88 ne of our predicted double mutants catalyzes dehalogenation of 1,2-dibromoethane more efficiently tha

89 us was expressed in tobacco resulting in the dehalogenation of 1,2-dichloroethane, which was otherwis

90 lyophilized enzyme powders for the gas-phase dehalogenation of 1-bromopropane.

91 AC to cathodes for electrochemical reductive dehalogenation of 15 halogenated alkanes and alkenes exh

92 Reductive dehalogenation of 1a was found to predominate in photoin

93 Complete dehalogenation of 20 mg L(-1) trichloroethylene was achi

94 lective addition of the radical derived from dehalogenation of 21 at the beta carbon of the (Z)-alpha

95 0% in the reported [Ru(bpy)(3)](2+)-mediated dehalogenation of 4-bromobenzyl-2-chloro-2-phenylacetate

96 A-CoA) dehalogenase catalyzes the hydrolytic dehalogenation of 4-CBA-CoA by attack of Asp145 on the C

97 A-CoA) dehalogenase catalyzes the hydrolytic dehalogenation of 4-CBA-CoA to 4-hydroxybenzoyl-CoA (4-H

98 A-CoA) dehalogenase catalyzes the hydrolytic dehalogenation of 4-CBA-CoA to 4-hydroxybenzoyl-CoA by u

99 A-CoA) dehalogenase catalyzes the hydrolytic dehalogenation of 4-CBA-CoA to 4-hydroxybenzoyl-CoA by u

100 fcb gene cluster involved in the hydrolytic dehalogenation of 4-chlorobenzoate is organized in the o

101 or activity in the formation of dTMP and the dehalogenation of 5-bromo- and 5-iodo-dUMP.

102 The rate of dehalogenation of 5-bromo-2'-deoxyuridine 5'-monophospha

103 ost N229 mutants exhibit no activity for the dehalogenation of 5-bromo-dUMP, which requires correct o

104 e mutants catalyzed the cofactor-independent dehalogenation of 5-bromodUMP; hence, the Asp side chain

105 ular carbon allotrope) can be synthesized by dehalogenation of a bromocyclocarbon precursor, C(18)Br(

106 This study focused on the reductive dehalogenation of a model organohalogen (triclosan) by 1

107 reductive dehalogenases were involved in the dehalogenation of all tested brominated benzenes, includ

108 Two mechanisms for the aqueous dehalogenation of aromatics involving nucleophilic aroma

109 yl chlorides and bromides, for the catalytic dehalogenation of aryl chlorides, and for the catalytic

110 compounds were assessed in the photoinduced dehalogenation of aryl halides, and analogues bearing el

111 ns: Suzuki-Miyaura cross-coupling, catalytic dehalogenation of aryl halides, and aryl amination.

112 utants as catalysts for cofactor-independent dehalogenation of BrdUMP, a reaction which simulates ear

113 able to efficiently perform NADPH-dependent dehalogenation of brominated and iodinated phenolic comp

114 shown to catalyze the glutathione-dependent dehalogenation of bromoacetate with a k(cat)/K(m) value

115 uster is CprA, which catalyzes the reductive dehalogenation of chlorinated aromatic compounds.

116 t enzyme in that superfamily associated with dehalogenation of chlorinated aromatics and appears to r

117 pproach to published experimental results on dehalogenation of chlorinated ethenes both in well-mixed

118 ted isotope enrichment factors for microbial dehalogenation of chlorinated ethenes vary considerably

119 imes have rarely been explored for reductive dehalogenation of chlorinated ethenes.

120 modeling approach we focus on the reductive dehalogenation of chlorinated ethenes.

121 es that can derive energy from the reductive dehalogenation of chlorinated organic compounds, many of

122 that some fraction of the cis-CaaD-catalyzed dehalogenation of cis-3-haloacrylates also proceeds by c

123 logenase (cis-CaaD) catalyzes the hydrolytic dehalogenation of cis-3-haloacrylates to yield malonate

124 halogenase lowers the activation barrier for dehalogenation of DCE by 2-4 kcal/mol relative to the si

125 The title fluoroalkene has been generated by dehalogenation of dibromide and diiodide precursors and

126 They catalyze the hydrolytic dehalogenation of either trans- or cis-3-haloacrylates t

127 re able to conserve energy via the reductive dehalogenation of halo-organic compounds in a respiratio

128 AtzA was shown to exclusively catalyze dehalogenation of halo-substituted triazine ring compoun

129 ornata is designed to catalyze the oxidative dehalogenation of halophenol substrates.

130 DHP catalyzes the H(2)O(2)-dependent dehalogenation of halophenols.

131 as also been shown to catalyse the reductive dehalogenation of hexachloroethane and pentachloroethane

132 We also show that TnIYD efficiently promotes dehalogenation of iodo-, bromo-, and chlorotyrosine, ana

133 ty through a highly enantioselective radical dehalogenation of lactones-a challenging transformation

134 diverse microorganisms couple the reductive dehalogenation of organohalides to energy conservation.

135 gested as important players in the reductive dehalogenation of organohalogens mediated by natural and

136 d from a chemostat study where the reductive dehalogenation of PCE was evaluated in the absence and p

137 Here, we report reductive dehalogenation of penta-BDEs and PCBs byDehalococcoides

138 ts in a graphene lattice by a stoichiometric dehalogenation of perchlorinated (hetero)aromatic precur

139 The reductive dehalogenation of perchloroethylene and trichloroethylen

140 Dehalogenation of perophoramidine (1) by ammonium format

141 w halogen substitution may form from in situ dehalogenation of PHCZs having more halogens.

142 genation, the scope of the catalyst includes dehalogenation of polychlorinated benzenes, bromobenzene

143 ity of this process allows for the selective dehalogenation of polyhalogenated products to form monoh

144 Dehalogenation of TCE resulted in a similar extent of C

145 Thus, Cys13 is required for the reductive dehalogenation of TCHQ.

146 quinone dehalogenase catalyzes the reductive dehalogenation of tetrachloro- and trichlorohydroquinone

147 ternative nor-B12 cofactor--were applied for dehalogenation of tetrachloroethene (PCE) or trichloroet

148 quinone dehalogenase catalyzes the reductive dehalogenation of tetrachlorohydroquinone and trichloroh

149 quinone dehalogenase catalyzes the reductive dehalogenation of tetrachlorohydroquinone and trichloroh

150 c acid dehalogenases catalyze the hydrolytic dehalogenation of the cis- and trans-isomers of 3-chloro

151 between Cys13 and glutathione formed during dehalogenation of the substrate.

152 PCBs, suggesting metabolic and co-metabolic dehalogenation of these compounds, respectively.

153 nas pavonaceae 170, catalyzes the hydrolytic dehalogenation of trans-3-chloroacrylate in the trans-1,

154 We report the electrocatalytic dehalogenation of trichloroethylene (TCE) by single soft

155 thway in which the products of the oxidative dehalogenation of trihalophenols (dihaloquinones) are th

156 s, none of the analogues underwent oxidative dehalogenation or glutathione adduction.

157 the discovery of an enantioselective radical dehalogenation pathway for alpha-bromoesters using flavi

158 The 4-chlorobenzoyl-CoA dehalogenation pathway in certain Arthrobacter and Pseud

159 Unlike the microbial dehalogenation pathway of haloacetic acids (HAAs), remov

160 A) in the final step of the 4-chlorobenzoate dehalogenation pathway.

161 y these two bacterial strains via dissimilar dehalogenation pathways and discuss the underlying mecha

162 CBDB1 and environmental fate modeling of the dehalogenation pathways.

163 u via hydrogen transfer oxidation or (pseudo)dehalogenation pathways.

164 logenation, and hexachloroethane binding and dehalogenation places conflicting demands on active-site

165 ated) vinyl radicals formed in the reductive dehalogenation process should be reduced to the correspo

166 nol system used in radical deoxygenation and dehalogenation processes has been investigated.

167 era known to be involved in halogenation and dehalogenation processes such as Bradyrhizobium or Pseud

168 Suzuki-Miyaura cross-coupling and catalytic dehalogenation processes, affording yields similar to th

169 Different effects on CF suppression and CT dehalogenation rate were expected because of the differe

170 d hexachloroethane binding but increased the dehalogenation rate.

171 linearly correlated with CF suppression and dehalogenation rate.

172 imiting step in the I12S and I12A enzymes is dehalogenation, rather than the thiol-disulfide exchange

173 owed that only S167A and S167G catalyzed the dehalogenation reaction and values of k(cat)/K(m) for th

174 ll three active site catalysts catalyzed the dehalogenation reaction as well as or better than the wi

175 The material was synthesized by an in situ dehalogenation reaction between a halogenated conjugated

176 th CCPO-I and -II to carry out the oxidative dehalogenation reaction is consistent with a mechanism i

177 Furthermore, the HE anion induces reductive dehalogenation reaction of aryl halides under visible li

178 cs simulations have been carried out for the dehalogenation reaction of the nucleophilic displacement

179 The dehalogenation reaction pathway shares at least two dire

180 xidize trihalophenols to dihaloquinones in a dehalogenation reaction that uses hydrogen peroxide as a

181 n is the rate-limiting step in the reductive dehalogenation reaction under physiological conditions.

182 A benchmark dehalogenation reaction was investigated with yields tha

183 ctions may be similar, the final step in the dehalogenation reaction, a thiol-disulfide exchange reac

184 steps in the initial stages of the reductive dehalogenation reaction.

185 gle proton is partially rate-limiting in the dehalogenation reaction.

186 o position for the hydrolysis portion of the dehalogenation reaction.

187 hotoredox catalysis for a green-light-driven dehalogenation reaction.

188 chloromethane and, like F(430), can catalyze dehalogenation reactions and produce lower halogenated p

189 The thermodynamic constraints of aromatic dehalogenation reactions are thus important for understa

190 Surface-confined dehalogenation reactions are versatile bottom-up approac

191 The dehalogenation reactions could be turned over with catal

192 alogenase catalyzes two successive reductive dehalogenation reactions in the pathway for degradation

193 high activity for alpha-ketone arylation and dehalogenation reactions of activated and unactivated ar

194 ook advantage of isotope effects in chemical dehalogenation reactions to generate (i) silver chloride

195 ing physiologically relevant deamination and dehalogenation reactions, respectively.

196 This reactivity was utilized to facilitate dehalogenation reactions, the reduction of electron-poor

197 bic microorganisms rarely catalyze reductive dehalogenation reactions.

198 tion for halogen atom transfer (XAT)-induced dehalogenation reactions.

199 on) and electron transfer (e.g., aryl halide dehalogenation) reactions under blue-light irradiation.

200 nyl as a small model system, we describe the dehalogenation, recombination, and diffusion processes.

201 l classes of environmental contaminants, and dehalogenation remains one of the most important process

202 tion in all natural and engineered reductive dehalogenations reported to date suggesting that OS-SET

203 nB catalyzing HCl elimination and hydrolytic dehalogenations, respectively, as initial steps in the m

204 irectly contribute to homocoupling and proto-dehalogenation side products that are commonly formed in

205 cant quantities of homocoupling and/or proto-dehalogenation side products.

206 echanism and factors affecting the undesired dehalogenation side reaction were revealed.

207 1,3-DCB or 1,2-DCB, demonstrated the widest dehalogenation spectrum of electron acceptors tested, an

208 ed the maximum rate (k(max)X) value for each dehalogenation step remained fairly constant, while hupL

209 For example, (1) a dehalogenation Suzuki-Miyaura cross-coupling sequence de

210 an operationally simple, tin-free reductive dehalogenation system utilizing the well-known visible-l

211 of halogenated alkenes is impeded by partial dehalogenation taking place during the hydroboration pro

212 evels traces the temperature of the onset of dehalogenation to around 475 K.

213 henacylchromanes is accompanied by reductive dehalogenation to form the corresponding 4-dichloromethy

214 genomic structures of many OHRB suggest that dehalogenation traits can be horizontally transferred am

215 respiratory activities and support reductive dehalogenation under acidic conditions, offering insight

216 molecule has been further utilized for mono-dehalogenation under visible light irradiation and selec

217 , and 2-iodothiophenes undergo photochemical dehalogenation via the triplet state.

218 to the TCE loss, suggesting that contaminant dehalogenation was the primary loss fate.

219 Hexachloroethane underwent rapid dehalogenation when carbon-centered radicals produced by

220 ichloroethene (TCE), and compared to abiotic dehalogenation with the respective purified corrinoids (

221 4-dichlorobenzoyl-CoA, NADPH-dependent ortho dehalogenation yielding 4-chlorobenzoyl-CoA, hydrolytic

222 Higher nuclearity photosensitizers produced dehalogenation yields greater than 90% in the reported [