ライフサイエンスコーパス: dehydroepiandrosterone

1 xysteroid sulfotransferase (SULT2A1) binding dehydroepiandrosterone.

2 over 200 mg from cheap and readily available dehydroepiandrosterone.

3 = 0.34), androstenedione (+17.1%, P = 0.06), dehydroepiandrosterone (+14.4%, P = 0.02), and dehydroep

4 etic analogue of the chemopreventive hormone dehydroepiandrosterone, 16alpha-fluoro-5-androsten-17-on

5 Dehydroepiandrosterone (25 mg/kg/day) and/or prednisone

6 urated with its primary endogenous substrate dehydroepiandrosterone 3-sulfate (DHEA-S) to yield a 2.6

7 enyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-s

8 ast to this finding, an active metabolite of dehydroepiandrosterone, 7-oxo-dehydroepiandrosterone, do

9 r arginine and/or glutamine, with or without dehydroepiandrosterone, a natural endogenous steroid, co

10 he 17-hydroxypregnenolone initial product to dehydroepiandrosterone, a process representing the first

11 lowing the adrenal to secrete high levels of dehydroepiandrosterone, an androgen precursor.

12 androgens with the additional measurement of dehydroepiandrosterone and 16-hydroxyprogesterone may al

13 Dehydroepiandrosterone and androstenediol (AED) have pre

14 onversion of the 17-hydroxylated steroids to dehydroepiandrosterone and androstenedione, respectively

15 There was a suggestion that dehydroepiandrosterone and dehydroepiandrosterone sulfat

16 uantitative determination of hydroxysteroids dehydroepiandrosterone and pregnenolone and their main m

17 o 5alpha-dihydrotestosterone, which bypasses dehydroepiandrosterone and testosterone, with increased

18 Steroidal (progesterone, dehydroepiandrosterone) and non-steroidal antagonists (v

19 progesterone, testosterone, androstenedione, dehydroepiandrosterone, and dehydroepiandrosterone sulfa

20 entrations of testosterone, androstenedione, dehydroepiandrosterone, and dehydroepiandrosterone sulfa

21 h using cyclosporine, mycophenolate mofetil, dehydroepiandrosterone, and intravenous immunoglobulin i

22 lucocorticoid antagonists, including RU-486, dehydroepiandrosterone, and progesterone.

23 anabolic-androgenic agents androstenedione, dehydroepiandrosterone, and the "parent" compound, testo

24 pregnenolone, progesterone, corticosterone, dehydroepiandrosterone, androstenedione, testosterone, 5

25 at/Km of the mutant is increased 6-fold with dehydroepiandrosterone as substrate.

26 termediate, yielding efficient production of dehydroepiandrosterone as the key intermediate in human

27 idoreductase deficiency results in disrupted dehydroepiandrosterone biosynthesis, explaining undervir

28 he prototypic hydroxysteroid SULT substrate, dehydroepiandrosterone, but both failed to catalyze the

29 eate the steroidogenic pathway upstream from dehydroepiandrosterone by documenting the presence of me

30 The pregnenolone, progesterone, and dehydroepiandrosterone content failed to change in rats

31 Whereas dehydroepiandrosterone conversion to DHT is usually very

32 Dehydroepiandrosterone (D) is biosynthesized in the brai

33 ernal standards, pregnenolone-d4 sulfate and dehydroepiandrosterone-d2 (DHEA), were used for quantita

34 one/testosterone), were significantly lower (dehydroepiandrosterone, Delta(4)-androstene-3,17-dione,

35 Dehydroepiandrosterone (DHEA) administration has been sh

36 The effects of dehydroepiandrosterone (DHEA) and 7-oxo-DHEA on the cell

37 ubsequent 17alpha,20-lyase reactions to form dehydroepiandrosterone (DHEA) and androstenedione (Andro

38 progesterone to the C19 androgen precursors dehydroepiandrosterone (DHEA) and androstenedione, respe

39 y converted pregnenolone and progesterone to dehydroepiandrosterone (DHEA) and androstenedione, respe

40 In contrast, the production of dehydroepiandrosterone (DHEA) and DHEA sulfate in the ad

41 ex steroid synthesis from adrenal precursors dehydroepiandrosterone (DHEA) and DHEA-sulfate has evolv

42 The adrenal steroid dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) ha

43 Dehydroepiandrosterone (DHEA) and its sulfate derivative

44 Dehydroepiandrosterone (DHEA) and its sulfate, DHEAS, ar

45 ymorphisms of the STS gene and SULT2A1 gene, dehydroepiandrosterone (DHEA) and its sulfated form (DHE

46 ions in hormone levels or precursors such as dehydroepiandrosterone (DHEA) and its sulfated form [col

47 Dehydroepiandrosterone (DHEA) and testosterone are widel

48 production of androgens, most significantly dehydroepiandrosterone (DHEA) and to a certain degree te

49 study was designed to assess the efficacy of dehydroepiandrosterone (DHEA) as a potential treatment.

50 oaded unimNPs with an endogenous S1R agonist dehydroepiandrosterone (DHEA) as an FDA-approved model d

51 s were conducted to evaluate the efficacy of dehydroepiandrosterone (DHEA) as an inhibitor of prostat

52 nd three women with INSR mutations underwent dehydroepiandrosterone (DHEA) challenge; serum androgens

53 S) concentrations by 88.2%, decreased plasma dehydroepiandrosterone (DHEA) concentrations by 84.6%, i

54 Age-related reductions in serum dehydroepiandrosterone (DHEA) concentrations may be invo

55 hypothesis that acute administration of oral dehydroepiandrosterone (DHEA) during episodes of repeate

56 The adrenal steroid dehydroepiandrosterone (DHEA) has antiglucocorticoid pro

57 The adrenal steroid dehydroepiandrosterone (DHEA) has been reported to act a

58 The adrenal steroid dehydroepiandrosterone (DHEA) has no known cellular rece

59 Pregnenolone (PREG) and dehydroepiandrosterone (DHEA) have been reported to impr

60 determine if the chemopreventive activity of dehydroepiandrosterone (DHEA) in the rat mammary gland c

61 ynthesis and release of the adrenal androgen dehydroepiandrosterone (DHEA) increases in response to s

62 Dehydroepiandrosterone (DHEA) is a C-19 adrenal steroid

63 Dehydroepiandrosterone (DHEA) is a neurosteroid with anx

64 Dehydroepiandrosterone (DHEA) is a neurosteroid with pot

65 Dehydroepiandrosterone (DHEA) is a peroxisome proliferat

66 The adrenal steroid hormone dehydroepiandrosterone (DHEA) is a potent inhibitor of m

67 Dehydroepiandrosterone (DHEA) is a ubiquitous adrenal ho

68 Dehydroepiandrosterone (DHEA) is a weak androgen also us

69 Dehydroepiandrosterone (DHEA) is an endogenous adrenal s

70 The adrenal androgen and neurosteroid dehydroepiandrosterone (DHEA) is available as over-the-c

71 liferative effects of the endogenous steroid dehydroepiandrosterone (DHEA) is not known.

72 Dehydroepiandrosterone (DHEA) is the most abundant circu

73 Dehydroepiandrosterone (DHEA) is the most abundant stero

74 6, LPV/r-treated infants had a higher median dehydroepiandrosterone (DHEA) level than infants from th

75 Imbalance of cortisol and dehydroepiandrosterone (DHEA) levels have been observed

76 kits were used to determine GCF cortisol and dehydroepiandrosterone (DHEA) levels.

77 t study examines the effect of administering dehydroepiandrosterone (DHEA) on short-term memory.

78 We have examined the effect of dehydroepiandrosterone (DHEA) on the development of EAE

79 This study examined the effect of exogenous dehydroepiandrosterone (DHEA) on the onset, incidence, a

80 article examines the effect of administering dehydroepiandrosterone (DHEA) on visual-spatial performa

81 Clinical studies showed that the androgen dehydroepiandrosterone (DHEA) reduced asthma symptoms in

82 Dehydroepiandrosterone (DHEA) regulates gene expression

83 To determine if dehydroepiandrosterone (DHEA) replacement improves insul

84 One indicator of this interest is that dehydroepiandrosterone (DHEA) supplements are widely con

85 By contrast, dehydroepiandrosterone (DHEA) suppressed VZ cell prolife

86 1) catalyzes the rate-limiting conversion of dehydroepiandrosterone (DHEA) to androstenedione (AD), t

87 s an enzyme that catalyses the conversion of dehydroepiandrosterone (DHEA) to androstenedione, a crit

88 catalyzes peripheral conversion from adrenal dehydroepiandrosterone (DHEA) to potent androgens and ha

89 Dehydroepiandrosterone (DHEA), a 19-carbon precursor of

90 Dehydroepiandrosterone (DHEA), a C19 human adrenal stero

91 We apply this technology to release dehydroepiandrosterone (DHEA), a neurosteroid that promo

92 used in the prevention of osteoporosis, and dehydroepiandrosterone (DHEA), a ubiquitous steroid prec

93 to assess possible antidepressant effects of dehydroepiandrosterone (DHEA), an abundant adrenocortica

94 PA dysfunction, evident by altered cortisol, dehydroepiandrosterone (DHEA), and cortisol:DHEA levels.

95 , is correlated with early morning cortisol, dehydroepiandrosterone (DHEA), and/or dehydroepiandroste

96 between mice receiving either vehicle alone, dehydroepiandrosterone (DHEA), or 2-difluoromethylornith

97 Administration of dehydroepiandrosterone (DHEA), or its sulfated form (DHE

98 nt with 5 mg/day testosterone (T), 75 mg/day dehydroepiandrosterone (DHEA), or placebo (P); and 57 el

99 Dehydroepiandrosterone (DHEA), the major steroid precurs

100 Dehydroepiandrosterone (DHEA), the predominant androgen

101 previous study showed that the neurosteroid dehydroepiandrosterone (DHEA), when administered preclin

102 The adrenal sex hormone dehydroepiandrosterone (DHEA), which is present in serum

103 erator, nafenopin, with those of the steroid dehydroepiandrosterone (DHEA).

104 t ability to sulfate hydroxysteroids such as dehydroepiandrosterone (DHEA).

105 ls of total testosterone, free testosterone, dehydroepiandrosterone (DHEAS), androstenedione, luteini

106 metabolite of dehydroepiandrosterone, 7-oxo-dehydroepiandrosterone, does not activate AR target gene

107 was found for the inhibitory actions of the dehydroepiandrosterone enantiomers.

108 ion of androstenedione from progesterone and dehydroepiandrosterone from pregnenolone.

109 (epinephrine, norepinephrine, cortisol, and dehydroepiandrosterone), immune activity (C-reactive pro

110 st notably, we observed marked elevations in dehydroepiandrosterone in the axilla and androstenedione

111 and can further metabolize steroids such as dehydroepiandrosterone into potent androgens, the de nov

112 The K(m) value of dehydroepiandrosterone is 13-fold greater, and the maxim

113 Dehydroepiandrosterone is the most abundant adrenal andr

114 -called 'anti-aging molecules', for example, dehydroepiandrosterone, is linked with enhanced lifespan

115 Further evidence was presented showing that dehydroepiandrosterone, leflunomide, and methotrexate ar

116 tive protein and lower free testosterone and dehydroepiandrosterone levels.

117 Low-dose vaginal estrogen, lidocaine, and dehydroepiandrosterone may also be considered in some ca

118 Both arginine and glutamine as well as dehydroepiandrosterone may be useful therapeutic agents

119 rost-1,5-diene-17-ethylene ketal (ADEK) from dehydroepiandrosterone metabolites and derivatives as a

120 mary metabolic route for the modification of dehydroepiandrosterone neurosteroids in the brain.

121 of those pathways and a specific inhibitor (dehydroepiandrosterone) of glucose-6-phosphate dehydroge

122 In rats, pretreatment with either dehydroepiandrosterone or fluvoxamine, a high-affinity s

123 reactions on a single protein that converts dehydroepiandrosterone or pregnenolone to androstenedion

124 phate dehydrogenase (G6PD) by treatment with dehydroepiandrosterone or the antisense DNA oligomer of

125 ng G6PD activity using an inhibitor of G6PD (dehydroepiandrosterone) or by inhibiting G6PD expression

126 hydroxyindoleacetic acid, homovanillic acid, dehydroepiandrosterone, or pregnenolone.

127 11-ketotestosterone, had significantly lower dehydroepiandrosterone (p < 0.001).

128 In the formation of the male hormone dehydroepiandrosterone, pregnenolone is first hydroxylat

129 We previously showed that dehydroepiandrosterone protects against renal ischemia-r

130 infected PLSJL mice with the steroid hormone dehydroepiandrosterone reduced BBB permeability changes

131 Dehydroepiandrosterone-replacement therapy has been intr

132 rone and pregnenolone to androstenedione and dehydroepiandrosterone, respectively, via 17alpha-hydrox

133 d arginine plus glutamine and treatment with dehydroepiandrosterone reversed the susceptibility to in

134 eutical treatments include the mild androgen dehydroepiandrosterone, selective estrogen receptor modu

135 otransferase (EST), and a hydroxysteroid ST, dehydroepiandrosterone ST (DHEA-ST).

136 ancer cell lines showed only trace levels of dehydroepiandrosterone ST and hEST activities.

137 onoamine-sulfating forms of phenol ST (PST), dehydroepiandrosterone ST, and estrogen ST (hEST), were

138 We previously reported that dehydroepiandrosterone-stimulated phosphorylation of Fox

139 hydroepiandrosterone (+14.4%, P = 0.02), and dehydroepiandrosterone sulfate (+7.2%, P = 0.26) compare

140 The unnatural enantiomers of dehydroepiandrosterone sulfate (1), pregnenolone sulfate

141 in saliva and found significantly increased dehydroepiandrosterone sulfate (DHEA-S) and reduced estr

142 The adrenal steroid dehydroepiandrosterone sulfate (DHEA-S) has been shown i

143 body of research has provided evidence that dehydroepiandrosterone sulfate (DHEA-S) is involved in a

144 monstrate the utility of the nanosensor with dehydroepiandrosterone sulfate (DHEA-S), a small-molecul

145 easing hormone, adrenocorticotropic hormone, dehydroepiandrosterone sulfate (DHEA-S), and cortisol.

146 ing retinoic acid and the endogenous steroid dehydroepiandrosterone sulfate (DHEA-S), it also has a c

147 port that chronic exposure to high levels of dehydroepiandrosterone sulfate (DHEA-S; converted in viv

148 The effect of dehydroepiandrosterone sulfate (DHEAS) administered i.p.

149 tmenopausal serum levels of testosterone and dehydroepiandrosterone sulfate (DHEAS) and subsequent ri

150 ements of serum cortisol, corticotropin, and dehydroepiandrosterone sulfate (DHEAS) are used to diagn

151 adult male mice with the neuroactive steroid dehydroepiandrosterone sulfate (DHEAS) at 1 and 40 mg/kg

152 associations between obesity indicators and dehydroepiandrosterone sulfate (DHEAS) at 7 y of age and

153 (DU-14) to rats for 15 days increased plasma dehydroepiandrosterone sulfate (DHEAS) concentrations by

154 could identify hits that sense steroids like dehydroepiandrosterone sulfate (DHEAS) down to 1.3 uM wi

155 Here, we report that dehydroepiandrosterone sulfate (DHEAS) is an endogenous

156 th PCOS have insulin resistance and elevated dehydroepiandrosterone sulfate (DHEAS) levels, which sup

157 (r > -0.6), bioavailable testosterone (BT), dehydroepiandrosterone sulfate (DHEAS), and the ratio of

158 ed inversely with plasma androstenedione and dehydroepiandrosterone sulfate (DHEAS), averaged across

159 terone, sex hormone-binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEAS), luteinizing horm

160 neurosteroids such as pregnenolone sulfate, dehydroepiandrosterone sulfate (DHEAS), pregnanolone, an

161 characterized by the usual overproduction of dehydroepiandrosterone sulfate (DHEAS), whose detection

162 nasteride revealed a significant increase in dehydroepiandrosterone sulfate (DHEAS).

163 fated steroids pregnenolone sulfate (PS) and dehydroepiandrosterone sulfate (DHEAS).

164 A receptor by another sulfated neurosteroid, dehydroepiandrosterone sulfate (DHEAS).

165 sterone, free testosterone, androstenedione, dehydroepiandrosterone sulfate (DHEAS)], sex hormone bin

166 ine in serum testosterone, androsterone, and dehydroepiandrosterone sulfate (P < .05 for all).

167 inding protein B [S100B]), stress (cortisol, dehydroepiandrosterone sulfate [DHEA-S] epinephrine, nor

168 that endogenous sex hormones (testosterone, dehydroepiandrosterone sulfate [DHEA-S], and estradiol)

169 inhibitory steroids pregnenolone sulfate and dehydroepiandrosterone sulfate act through a common inte

170 PREGS potentiation of mEPSCs was mimicked by dehydroepiandrosterone sulfate and (+)-pentazocine but n

171 ibition of OATP1B3-1B7-mediated transport of dehydroepiandrosterone sulfate and identified several in

172 ational study found lower, but still normal, dehydroepiandrosterone sulfate concentrations in statin-

173 The levels of the AR ligand precursor dehydroepiandrosterone sulfate correlated positively wit

174 Dehydroepiandrosterone sulfate had a borderline associat

175 We examined testosterone, estradiol, and dehydroepiandrosterone sulfate in relation to incident A

176 served enantioselectivity for the actions of dehydroepiandrosterone sulfate indicates that its inhibi

177 , via administration of the enzyme substrate dehydroepiandrosterone sulfate or the enzyme inhibitor C

178 androstenedione, dehydroepiandrosterone, and dehydroepiandrosterone sulfate were associated with risk

179 androstenedione, dehydroepiandrosterone, and dehydroepiandrosterone sulfate were determined by liquid

180 a suggestion that dehydroepiandrosterone and dehydroepiandrosterone sulfate were inversely associated

181 androgens testosterone, androstenedione, and dehydroepiandrosterone sulfate were negatively associate

182 impact of SLCO2B1 expression level on DHEAS (dehydroepiandrosterone sulfate) uptake was evaluated in

183 baseline SA (testosterone, androstenedione, dehydroepiandrosterone sulfate), was measured by ultrase

184 ports taurocholic acid, the adrenal androgen dehydroepiandrosterone sulfate, and thyroid hormone, as

185 physical activity, social class, education, dehydroepiandrosterone sulfate, androstanediol glucuroni

186 terol, high-density lipoprotein cholesterol, dehydroepiandrosterone sulfate, cortisol, systolic and d

187 rone sulfate, androstenedione, testosterone, dehydroepiandrosterone sulfate, follicle-stimulating hor

188 s of estrone, estradiol, testosterone, SHBG, dehydroepiandrosterone sulfate, free estradiol, and free

189 +CD38+HLA-DR+, and CD8+CD38+HLA-DR+ T cells, dehydroepiandrosterone sulfate, free testosterone, homeo

190 re found for endogenous estrogens, cortisol, dehydroepiandrosterone sulfate, insulin, glucagon, or fo

191 lerosis and increasing quartiles of estrone, dehydroepiandrosterone sulfate, or androstenedione.

192 a,17beta-diol disulfate 2, P = 0.000064; and dehydroepiandrosterone sulfate, P = 0.00011).

193 iol, estrone, estrone sulfate, testosterone, dehydroepiandrosterone sulfate, prolactin, and sex hormo

194 tic levels of testosterone, androstenedione, dehydroepiandrosterone sulfate, sex hormone-binding glob

195 ten-3beta,17beta-diol disulfate 1 and 2, and dehydroepiandrosterone sulfate, were the next most stron

196 on of ERK1 and ERK2; however, the steroid PP dehydroepiandrosterone sulfate, which does not induce im

197 , but not by phenobarbital or the steroid PP dehydroepiandrosterone sulfate.

198 allo-tetrahydrocortisol, and the presence of dehydroepiandrosterone sulfate.

199 licle-stimulating hormone, testosterone, and dehydroepiandrosterone sulfate.

200 itor oxythiamine (OT) and the G6PD inhibitor dehydroepiandrosterone-sulfate (0.5 microM each) exerted

201 iveness and lower levels of androstenedione, dehydroepiandrosterone-sulfate (DHEA-S) and free PSA%, a

202 tisol, dehydroepiandrosterone (DHEA), and/or dehydroepiandrosterone-sulfate (DHEA-S) concentrations.

203 1.16-3.57; P = 0.01), lower plasma levels of dehydroepiandrosterone-sulfate (OR per 1-ln decrease = 2

204 1.16-3.57; P = 0.01), lower plasma levels of dehydroepiandrosterone-sulfate (OR per 1-ln decrease = 2

205 udy to determine whether hormone levels (E2, dehydroepiandrosterone-sulfate [DHEA-S], and testosteron

206 In vivo testing of 400 mg/kg OT or dehydroepiandrosterone-sulfate in C57BL/6 mice hosting E

207 Dehydroepiandrosterone-sulfate, a unique PP in being a s

208 activation via sulfonation of the hormone by dehydroepiandrosterone sulfotransferase (DST), an androg

209 Dehydroepiandrosterone sulfotransferase (Std) catalyzes

210 Dehydroepiandrosterone sulfotransferase (STD) is a hydro

211 xpression of the phase II conjugating enzyme dehydroepiandrosterone sulfotransferase (STD) known to s

212 Dehydroepiandrosterone sulfotransferase (SULT2A1) is a c

213 phenol sulfotransferases, HAST1, -3, and -4, dehydroepiandrosterone sulfotransferase, and estrogen su

214 nfluence steroid/xenobiotic metabolism using dehydroepiandrosterone sulfotransferase.

215 bum lipids and the immunostimulatory hormone dehydroepiandrosterone sulphate in the COVID-19 positive

216 depression scores; higher baseline cortisol: dehydroepiandrosterone sulphate ratio (men only) and hig

217 Evidence is accruing in support of dehydroepiandrosterone supplementation in adrenal insuff

218 o-conjugation of endogenous hydroxysteroids (dehydroepiandrosterone, testosterone, bile acids), and d

219 ollowed by a 17,20-lyase reaction to produce dehydroepiandrosterone, the key intermediate in human sy

220 erone and dihydrotestosterone, together with dehydroepiandrosterone, the precusrsor to all androgens,

221 n the other hand, neither isoform sulfonates dehydroepiandrosterone to any significant degree.

222 in conversion of the adrenal-derived steroid dehydroepiandrosterone to DHT.

223 and oxidizes cholesterol, pregnenolone, and dehydroepiandrosterone to their respective 3-keto-4-ene

224 The enzyme shows no substrate preference for dehydroepiandrosterone versus pregnenolone with second-o

225 The presence of dehydroepiandrosterone was associated with 16-hydroxypro

226 Preflight dehydroepiandrosterone was positively associated with co

227 Dehydroepiandrosterone was reduced in the cachectic pati

228 Among 22 derivatives/metabolites of dehydroepiandrosterone, we found 4 steroids [no. 4, 1,3,

229 limits of androsterone, epiandrosterone, and dehydroepiandrosterone were 1-2 orders of magnitude grea

230 ficient subjects, plasma androstenedione and dehydroepiandrosterone were in a range similar to that o

231 f both 1 alpha, 25-dihydroxy vitamin D 3 and dehydroepiandrosterone were used together as hormonal im

232 regnanolone, pregnenolone, testosterone, and dehydroepiandrosterone) were isolated from the plasma or

233 ds through the adrenal sex steroid precursor dehydroepiandrosterone, which is converted to testostero

234 of men were identified with low circulating dehydroepiandrosterone who showed altered adrenal steroi

235 Trilostane is a competitive inhibitor of dehydroepiandrosterone with a Ki of 197 +/- 8 microM.