ライフサイエンスコーパス: deletion

1 g the immune response, were affected by PTEN deletion.

2 ice bearing the Asah1 podocyte-specific gene deletion.

3 II and III gliomas associated with 1p/19q co-deletion.

4 t are differentially regulated upon Smarcad1 deletion.

5 23 was abrogated by GPAT inhibition or Lpar1 deletion.

6 te (0.9%; 1/113) potentially has pfhrp2 gene deletion.

7 promoting antigen-induced peripheral T cell deletion.

8 e removed by FEN1, thereby leading to repeat deletion.

9 tion blockage via BCL2 overexpression or BAX deletion.

10 s of the same four cell types upon FMR1 gene deletion.

11 ts on RBC production mediated by EPO or Tfr2 deletion.

12 being either resistant or sensitive to G3BP deletion.

13 s are limited in their ability to make large deletions.

14 ntly more clonal CXCR4 mutations (P = .015), deletion 13q (P = .006), splenomegaly (P = .02), and thr

15 e polymorphisms (SNPs), in-frame indels, and deletions; 2) single/multigene deletion; and 3) movement

16 LostArc reveals 35 million deletions (~ 470,000 unique spans) in skeletal muscle fr

17 (P = .004), whereas PC-like WM harbored more deletion 6q (P = .012), gain 6p (P = .033), had increase

18 Moreover, YY1 deletion abrogated its interaction with histone deacetyl

19 N-terminal TMIE deletions affect the response of the mechanotransduction

20 TIMP1 deletion allows senescence to promote metastasis, and el

21 Since Igf1r deletion allows the evasion of early developmental arres

22 However, EPO or Tfr2 single-allele deletion alone, respectively, exacerbated or did not imp

23 ome parasite isolates possessed mixed PfRh2b deletion and full-length alleles.

24 st tier 2 pseudoviruses with targeted glycan deletion and high-mannose glycan enrichment.

25 Combining SE deletion and KO and wild-type alleles in a genotypic ser

26 Using U(S)3 deletion and U(S)3 kinase-dead recombinant MDV, we ident

27 22q11.2 deletions and duplications are copy number variations (C

28 port that F(1) survivors due to primary-site deletions and indels occur at a 5.8 x 10(-6) frequency,

29 Extensive CT deletions and mutagenesis analyses helped us zoom in on

30 Inactivation of Pten gene through deletions and mutations leading to excessive pro-growth

31 f HMAs in AML/MDS patients with chromosome 7 deletions and other monosomal karyotypes.See related com

32 patient samples (n = 94) harbor chromosomal deletions and/or loss-of-function mutations in RB1 and T

33 site, six missense variants and one in-frame deletion) and one family with a missense variant inherit

34 ctivity is clinically relevant as mutations, deletions, and amplifications that increase CDK4/6 activ

35 three basic types of DNA errors: insertions, deletions, and substitutions.

36 gains/amplifications, 19p13/CD70 homozygous deletions, and TP53 and MYC mutations.

37 rspersed segmental duplications, inversions, deletions, and translocations using linked-read sequenci

38 e indels, and deletions; 2) single/multigene deletion; and 3) movement of mobile genetic elements (in

39 C(H)2s has a 7-residue deletion at the N-terminus and a 16-residue C-terminal e

40 The success of each multiple-gene deletion attempt could only be partially predicted on th

41 uous LCR22 structures surrounding and within deletion breakpoints.

42 binding site of SrmB is unperturbed by SrmB deletion, but the peptidyl transferase center, the uL7/1

43 relevant to ASD and psychosis in 106 22q11.2 deletion carriers, 38 22q11.2 duplication carriers, and

44 ted intestinal crypt cells showed that Bccip deletion caused an overwhelming down-regulation of genes

45 LRG1 deletion causes impaired immune cell infiltration, reepi

46 Maf and Mafb conditional deletion (cDKO) decreases the survival of MGE-derived co

47 l engineered with a noncoding intronic 10 bp deletion (del10) in Hgf Male and female mice homozygous

48 With oxidative stress, MSH3 with this deletion (Delta27bp MSH3) localizes to the cytoplasm, su

49 reverse the antihypertrophic effect of ACC2 deletion demonstrating a causal role of elevated asparta

50 nt preclinical data have emerged from GM-CSF deletion/depletion approaches indicating that GM-CSF is

51 Finally, we show how insertions and deletions differ in their dependencies on these repair p

52 ange of hair-bundle regulators and late Six1 deletion disrupts hair-bundle polarity.

53 We show that, although Lgr4 deletion does not appear to affect the number of quiesce

54 We generated and subjected mice with EC-AGO1 deletion (EC-AGO1-knockout [KO]) and their wild-type lit

55 ed through 3' adenylation, uridine insertion/deletion editing, and 3' A/U-tailing.

56 rsal, inferring on which edges insertion and deletion events occurred using those internal node decor

57 and we could show that some of the predicted deletions exhibit increased ethanol levels in comparison

58 In the deletion experiments we excised ~ 15 kilobases of DNA th

59 Individuals with higher similarity to deletion FC-signatures exhibit worse cognitive and behav

60 in gene expression compared with whole-gene deletions for these COMPASS members.

61 ropomyosin receptor kinase B (TrkB) receptor deletion from D1-expressing cells (D1-Cre-flTrkB) in whi

62 But irrespective of intron 1 position, OSRE1 deletion from intron 1 abolishes hyperosmotic enhancer a

63 vels were reduced in stroma following alpha3 deletion from tumor cells.

64 ential for proper functioning of FtsH as its deletion fully eliminated the proteolytic activity of Ft

65 date the role of the CR and determine why CR deletion generates toxicity, we designed PrP(C) construc

66 cation in Burkitt's lymphoma, homozygous Mnt deletion greatly reduced lymphoma incidence by enhancing

67 HIF-1alpha deletion had no effect on the increase in normoxic venti

68 Finally, we show that gene deletion has further shaped the SVMP complex within ratt

69 imately 23% of patients with nested LCR22C-D deletions have CTDs, and inactivation of Crkl in mice ca

70 Ealpha on the proximal Valpha genes, and its deletion impaired the Tcra rearrangement.

71 However, T cell-specific PKM2 deletion impairs Th17 cell differentiation and ameliorat

72 of tumor-infiltrating T cells following Yap deletion implicates Yap as a mediator of global T-cell r

73 CITED4 deletion in cardiomyocytes did not affect baseline cardi

74 Moreover, deletion in granule cells of the OB of Bai3, a postsynap

75 icantly altered by both mutation and allelic deletion in human cancer, but the functional implication

76 Using genetic deletion in mouse embryo fibroblasts and a combination o

77 asses of genes responded differently to XRN1 deletion in mRNA synthesis and were differentially regul

78 We have found that Fth deletion in NG2-positive OPCs significantly delays the r

79 revealed a recessive germline 21-bp in-frame deletion in NUAK2 segregating with the disease.

80 Fgf23 deletion in Ocys blocked these changes.

81 rical control of bacterial flagella, and its deletion in polarly flagellated bacteria typically leads

82 ie) mice, which contain a spontaneous 150-kb deletion in the Ddr2 locus to produce an effective null.

83 Accordingly, an rTCRV containing this 39-nt deletion in the L-IGR (rTCRV/Delta39) exhibited decrease

84 ls, suggesting the feasibility of using this deletion in the L-IGR as an approach to attenuate TCRV,

85 We generated a series of genetic deletions in an apicoplast metabolic bypass line to dete

86 translated regions of NFKBIZ and TOB1, focal deletions in BRD4 and rearrangements in the loci of AKR1

87 nucleotide variants and small insertions and deletions in exomes has been understudied.

88 Using conditional deletions in mice as well as CRISPR/Cas9 approaches to t

89 lso examined the noncoding genome, and found deletions in regulatory regions that contribute to disea

90 We performed an extensive validation of all deletions in the significant set of voltage-gated calciu

91 ontained mutations in FOXA1 and 18% each had deletions in ZNF292 and CHD1.

92 Max deletion increases growth and transformation in cells an

93 entification of expressed somatic insertions/deletions (indels) is an unmet need due to artifacts gen

94 eotide variants (SNVs), small insertions and deletions (indels), copy-number variations (CNVs), loss

95 ison with bwa, especially for insertions and deletions (indels).

96 le nucleotide variants (SNVs) and insertions/deletions (indels).

97 hed at meiotic kinetochores and its targeted deletion induces centromere instability and abnormal chr

98 of the P4 residue on the sensitivity to G3BP deletion is abolished.

99 either systemic or neutrophil-specific Akt1 deletion is sufficient to inhibit metastasis of Akt-prof

100 en applied to generate random insertions and deletions, large deletions, targeted insertions or repla

101 endent on its C-terminal lysine residue; its deletion led to modest reductions in complement resistan

102 ese RNA-protein interactions due to the SINE deletion likely creates more available TDP-43 binding si

103 mRNA sequencing revealed that systemic Akt1 deletion maintains the pro-metastatic cluster within pri

104 imary source of chromosome translocations or deletions, making them a major cause of genomic instabil

105 Inducible cardiomyocyte-specific Tjp1 deletion mice (Tjp1(fl/fl); Myh6(Cre/Esr1*)) were genera

106 r recently established mammary specific Tet2 deletion mouse model, the data reveals that TET2 plays a

107 LN3(R334C) and for a JNCL-related C-terminal deletion mutant (CLN3DeltaC).

108 Mapping of digenic interactions for a deletion mutant of each paralog, and of trigenic interac

109 n-independent growth of the M. smegmatis tam deletion mutant strain.

110 ties identical to those of the corresponding deletion mutant strains.

111 he thermosensitive growth of the yeast mms19 deletion mutant while expression of the diminutive allel

112 We further generated a lon-2 deletion mutant.

113 ened the genome-wide library of viable yeast deletion mutants for defects in the degradation of corti

114 phenocopies that of ISC1 Reciprocally, ISC1 deletion mutants were sensitive to benomyl, indicating a

115 Among various deletion mutants, only full-length Mdm4 was able to supp

116 Furthermore, by imaging deletion mutants, we observed functional differences bet

117 82 intraspecific substitution and insertion/deletion mutations, and provided evidence for correction

118 nd that RNF8 suppresses EJ without insertion/deletion mutations, which is a hallmark of C-NHEJ.

119 A 103.3 kb deletion NC_006610.3CFA28:g.23380074_23483377del, contai

120 nds to the break site for a large (3,895 bp) deletion observed in mitochondrial disease patients.

121 Deletion of -31CBS reduces chromatin accessibility and b

122 Deletion of 4E-BP2 specifically in inhibitory neurons al

123 tation to produce cell-specific knockdown or deletion of a key NMDAR subunit, GluN2B, implicated in t

124 Here, we report that deletion of a regulatory element in the HOTAIR locus inc

125 Deletion of a Samd14 enhancer (Samd14-Enh), occupied by

126 The deletion of a single NPD gene (npd2) or all five members

127 obese phenotype, increasing FAO oxidation by deletion of ACC2 prevented HFD-induced cardiac dysfuncti

128 Neural crest specific conditional deletion of Adar1 in mice leads to global depigmentation

129 Here, we report that inducible deletion of adipose OGT causes a rapid visceral fat loss

130 In cultured neurons, deletion of all LAR-RPTPs led to a reduction in synaptic

131 endent astroglial activation is abolished by deletion of alpha(1A)-adrenergic receptor from astroglia

132 irect calorimetry analyses revealed that the deletion of ALX dysregulated energy metabolism driving t

133 Functionally, deletion of Bbeta2 and maintained Drp1 Ser637 phosphoryl

134 nd excitotoxicity in vitro and ex vivo Last, deletion of Bbeta2 rescued excessive stroke damage assoc

135 Mice harboring a macrophage-specific deletion of BCAP fail to recover from and succumb to dex

136 Here, we demonstrate that deletion of beta-klotho in glutamatergic, but not GABAer

137 the presence of darT(Mtb) , but simultaneous deletion of both darT(Mtb) -darG(Mtb) does not alter via

138 a mouse model of SCLC induced by conditional deletion of both Trp53 and Rb1 in the adult airway.

139 Although deletion of BRD2 enhances sensitivity to BBDIs, BRD7 los

140 Deletion of C1ql3 in the dorsolateral AON impaired synap

141 naling, we next generated mice with specific deletion of cacna1c from D1R-expressing neurons (D1-cacn

142 Deletion of Cav-1 scaffold domain binding (CSD) motif in

143 ce with different cell type specific genetic deletion of CB1 was studied.

144 Deletion of Ccr2 in cancer cells resulted in multiple al

145 Deletion of Csk and PTPRJ in the MK lineage in mice resu

146 However, here we show that deletion of CTK complex components in Neurospora led to

147 Deletion of CypD also prevented KET-induced behavioral d

148 Deletion of DNA-PK or PTEN, or inhibition of DNA-PK sens

149 We generated mice with genetic deletion of Dnmt3a and Dnmt3b in nephron progenitor cell

150 Finally, deletion of Dot1L in T cells resulted in an impaired imm

151 Deletion of DR/DQ-SE resulted in reduced expression of H

152 ced by nlp-2 overexpression is diminished by deletion of either gnrr-3 or gnrr-6.

153 Deletion of either kinase domain or death domain in the

154 Deletion of either ZF delayed the delivery of gRNA to th

155 Surprisingly, global deletion of either, or both, isoform(s) was without sign

156 Deletion of essential autophagy genes increased the sens

157 Homozygous deletion of ETV4, using CRISPR/Cas9, led to greatly redu

158 C-deficient mouse (Twitcher), and widespread deletion of GALCLAMP1 recapitulates the Twitcher phenoty

159 that significantly worsen following combined deletion of Gas1 and Boc Together, these data indicate t

160 pression of Cre recombinase mediates precise deletion of genetic elements in a spatially- and tempora

161 Combined deletion of GRA12 and ROP18 induced more severe attenuat

162 In this report we discover that genetic deletion of Gravin disrupts proper accumulation and asym

163 A previous report has shown that germline deletion of Grb14 in mice results in cardiac hypertrophy

164 Conditional deletion of Hdac3 within myeloid progenitors accelerates

165 Deletion of histone deactelyase 6 (HDAC6), a cytosolic d

166 Deletion of HuR does not impair neural progenitor cell p

167 Deletion of iNKT cells in Cd1d-/- mice or inhibition of

168 Embryonic deletion of integrin beta1 in the liver disrupts the nor

169 itoneal injection of l-arginine in mice with deletion of interleukin (IL)12B, NLRP3, or IL18 and in m

170 IL-1beta stimulation, which was abrogated by deletion of IRAK4.

171 oxicity phenotype, which was alleviated upon deletion of its N terminus.

172 e entire IR-R repeat or, to a lesser degree, deletion of just the B boxes impaired the de novo establ

173 In vessels from mice with deletion of Kir6.1 (Kir6.1(-/-) ) or SUR2 (SUR2[STOP]) s

174 Global deletion of Kir6.1 or SUR2 subunits results in severely

175 Deletion of LAR-RPTPs decreased NMDA-receptor-mediated r

176 Strikingly, deletion of LAR-RPTPs had no effect on synaptic connecti

177 Specific deletion of LAT1 in gammadelta and CD4 T cells controls

178 Deletion of LXR alpha/beta from sensory neurons lead to

179 Deletion of M-opsin relieves the proteasome stress and c

180 h nodes for processing by cDC2, as selective deletion of major histocompatibility class II molecules

181 ns, which mediate inflammatory responses.(,) Deletion of miR-146a in mice phenocopies many aspects of

182 Crispr-Cas9-mediated deletion of Mm47, as well as small interfering RNA studi

183 Deletion of MORs from KF neurons also relieved rate depr

184 N-glycans in developing B cells via targeted deletion of N-acetylglucosaminyl transferase I (Mgat1) m

185 Progressive deletion of N-terminal residues revealed an unexpected c

186 Accordingly, despite mice with conditional deletion of Nf1 in mature osteoblasts (Nf1(fl/fl);Dmp1-C

187 Conditional deletion of NKG2D in T cells impairs the ability of anti

188 of the nucleocapsid component VP35 overcomes deletion of NP-Ct in triggering IB formation, demonstrat

189 ns of miRNA sequences, harboring addition or deletion of one or more nucleotides at the 5' and/or 3'

190 ) and pilocarpine in mice with a conditional deletion of Orai1 (or its activator STIM1) in the brain.

191 We show that the selective deletion of OXT receptors from MCH neurons increases and

192 Chemogenetic inhibition or deletion of p11 in these cells induced vulnerability to

193 e surprising finding that adipocyte-specific deletion of P2Y(6)R protects mice from diet-induced obes

194 (ECs) under both normal conditions and after deletion of Pdcd10 (Ccm3) in a mouse model of CCM.

195 le intestinal epithelial cell (IEC)-specific deletion of Phb1 (Phb1(iDeltaIEC)) and mice with IEC-spe

196 Though homozygous deletion of Poldip2 is lethal, heterozygous mice are via

197 Deletion of PRC2, Dnmt1/3a/3b or Mecp2 in ESCs leads to

198 Furthermore, deletion of prodynorphin in the BNST and chemogenetic in

199 Conditional genetic deletion of PTEN results in robust CNS axon regrowth, wh

200 Hematopoietic cell-specific deletion of PTN suppressed CML development in BCR/ABL+ m

201 phorylation, and chondroitinase treatment or deletion of PTPsigma increases TRKB phosphorylation.

202 teracted with IFT dynein subunit D1bLIC, and deletion of residues 261-275 reduced this interaction.

203 Deletion of residues 342-356 of Chlamydomonas IFT54 resu

204 cted SREBF1 mutations caused substitution or deletion of residues 527, 528, and 530, which are crucia

205 This was functionally relevant, as deletion of RUNX1 in ccRCC cell lines reduced tumor cell

206 Preferential deletion of Shank3 in vS1 inhibitory interneurons led to

207 Deletion of SNORD42A decreased 18S-U116 2'-O-methylation

208 se of a viral genetic system that allows for deletion of specific viral genes in discrete populations

209 ouse mammary tumor model, we discovered that deletion of TGFbeta signaling on myeloid cells (PyMT/TGF

210 an intact C-tail has no affinity for DNA but deletion of the C-tail greatly increases Mtf1's DNA bind

211 visiae, dna2Delta inviability is reversed by deletion of the conserved helicase PIF1 and/or DNA damag

212 In this DNA demethylated context, either deletion of the CTCF binding site or depletion of RAD21

213 Here, deletion of the dpy19 gene in the parasite Toxoplasma go

214 Deletion of the EDTEE sequence did not increase the sens

215 Hemizygous deletion of the elastin gene (ELN) causes Williams-Beure

216 Deletion of the entire IR-R repeat or, to a lesser degre

217 Deletion of the gene encoding the leptin receptor in eit

218 administration of intragastric sucrose, and deletion of the NMDA receptor in these neurons, which af

219 Deletion of the NTE from MOB1A or addition of NTE peptid

220 one of the most sensitive wild isolates, and deletion of the only G-protein beta-subunit-encoding gen

221 Deletion of the optix patterning gene also altered color

222 We also confirmed that the targeted deletion of the pe/ppe genes in M. tuberculosis resulted

223 In vivo-specific deletion of the Sema3E high-affinity receptor, plexinD1,

224 ce electrophysiology and mice with a genetic deletion of the specific subunit of system x(c)(-), xCT

225 HEK2-p53 DNA damage response, as concomitant deletion of the Trp53 tumor suppressor or Chek2 DNA dama

226 Interestingly, deletion of the uORF led to higher shoot Pi content and

227 Using CXCL12 as a model CXC chemokine, deletion of the X residue (Pro-10) had little to no impa

228 Deletion of this enhancer from the genome of mice result

229 tamoxifen-induced conduction system-specific deletion of Tjp1 (Tjp1(fl/fl); Hcn4(CreERt2)) developed

230 ck while tamoxifen-induced conduction system deletion of Tjp1 distal to the AV node (Tjp1(fl/fl); Kcn

231 Tph1(-/-) mast cells or selective mast cell deletion of Tph1 enhances uncoupling protein 1 (Ucp1) ex

232 Mice with myeloid-specific gene deletion of Traf3ip3 have increased RNA virus-triggered

233 In conclusion, genetic deletion of TRAIL receptor increased the DR cell populat

234 Tissue-specific deletion of TRIM71 in the male germline led to reduction

235 topoietic cells, was sufficient for complete deletion of TRP1-specific thymocytes.

236 Deletion of Trp53 in gastric cells confers a selective a

237 Deletion of Trpm7 and inhibition of TRPM7 channel activi

238 Inducing fibroblast-specific deletion of Txndc5 mitigates the progression of BLM-indu

239 ar residues at both the N and C termini, and deletion of up to 11 C-terminal residues had little impa

240 Furthermore, deletion of Vegfc from the microenvironment delayed hema

241 Both global and conditional deletion of Vegfc in endothelial or leptin receptor-posi

242 Conditional deletion of VMAT2 in astrocytes postnatally produces los

243 Finally, we report that mice with a deletion of VPS41 specifically in beta-cells develop dia

244 Genetic deletion of XPO5 compromises the biogenesis of most miRN

245 Conditional deletion of YAP or TAZ resulted in more severe and prolo

246 al co-inhibition of YAP and TEAD, or genetic deletion of YAP1, all deplete dormant cells by enhancing

247 Moreover, responses of the models to deletions of a current can be different at high and low

248 Deletions of the CBS or the TSS individually or in combi

249 The deletions of two critical motifs, which interact with th

250 velopmental condition caused by a hemizygous deletion on chromosome 22-is associated with an elevated

251 applicable in achieving more predictable and deletion-only MMEJ-mediated mutations in many plant spec

252 Either genetically directed deletion or acute optogenetic silencing of DR(Sert) neur

253 Genetic deletion or chemical inhibition of AP-1 suppresses growt

254 Accordingly, deletion or depletion of the N-end rule pathway ubiquiti

255 urators to assign labels describing SV type (deletion or insertion), size accuracy, and genotype for

256 Deletion or substitution of this 'master controller' pre

257 In vivo deletion or supplementation of LXA(4) identified modulat

258 were found in the M-DeltaM51 protein, and no deletions or mutations were found in the p53 or eqFP650

259 egenerating transgenic fish, and its genomic deletion perturbed caudal fin regeneration and abrogated

260 kpoint genes act upstream of Isc1, and their deletion phenocopies that of ISC1 Reciprocally, ISC1 del

261 al was lower among patients who had an IKZF1 deletion plus additional genetic aberrations (CDKN2A or

262 Furthermore, Tet2 deletion-PyMT breast cancer mouse model exhibits enhance

263 tion within the hotspot analogous to a human deletion, recapitulates hypertension with brachydactyly.

264 NRG1 deletion reduces proliferation in intestinal crypts and

265 argets containing mismatches, insertions and deletions relative to the guide RNA.

266 Accordingly, LAYN deletion resulted in attenuated LFA-1-dependent cellular

267 miR-31 deletion resulted in suppression of miR-31-associated EG

268 Notably, only 14% of the boundary deletions resulted in a change in expression in nearby g

269 In contrast, we find that Boc deletion results in facial widening that correlates with

270 Cell-specific deletion reveals a requirement for GATA6 in various SAN

271 nd genotype for 1235 putative insertions and deletions sampled from different size bins between 20 an

272 and sensitive viruses also switches the G3BP deletion sensitivity.

273 Nematodes with this in-frame deletion show defective locomotion and muscle force gene

274 base-substitution and 17 small insertion-and-deletion signatures.

275 Deletion similarities identified at the connectivity lev

276 cal brain structures, which were affected by deletion size and psychotic illness.

277 rtificial medium, and an A. tumefaciens vtlR deletion strain is defective in motility, biofilm format

278 In an hns deletion strain, LuxR is no longer necessary for transcr

279 In cells of a PEX3 deletion, strain Inp1-GFP localizes to the plasma membra

280 isting collection of viable ADP1 single-gene deletion strains and a new transposon insertion sequenci

281 We phenotype gene-deletion strains of fission yeast in 59,350 individual f

282 Constitutive PTN deletion substantially reduced the numbers of CML stem c

283 22q11.2 deletion syndrome (22q11DS)-a neurodevelopmental conditi

284 erate random insertions and deletions, large deletions, targeted insertions or replacements of short

285 probes the chromatin models using in silico deletion to find the most relevant TRs.

286 residues in RD3 by single substitutions and deletions to identify side chains that are critical for

287 signaling increased in tumor-MDSCs, and its deletion transformed MDSCs into myeloid cells that activ

288 NCLX deletion transforms the adrenergic pathway responsible f

289 NAs that require extensive uridine insertion/deletion (U-indel) editing for their maturation.

290 The highly prevalent GSTM1 deletion variant is associated with kidney disease progr

291 y analyzed enhancer-associated insertion and deletion variants for both human and murine samples usin

292 overall topology was examined using several deletion variants.

293 Psychotic illness in this highly penetrant deletion was associated with similar neuroanatomic abnor

294 Amplicons with large internal deletions were excluded (<9 kb).

295 Only a small subset of biallelic deletions were predicted to result in coding exon disrup

296 In total, 4 exonic, single-gene deletions were validated in schizophrenia cases and none

297 cytosis was abrogated by global REV-ERBalpha deletion, which caused persistently elevated synaptic ph

298 ncreased bacterial ingestion following Bmal1 deletion, which was also seen in vitro.

299 CRISPR/Cas9-generated rat model, with a 9-bp deletion within the hotspot analogous to a human deletio

300 hes, we demonstrate that whereas Gpbar1 gene deletion worsens the severity of liver injury, its pharm