ライフサイエンスコーパス: demethylase

1 ngle methyltransferase (Dot1l) with no known demethylase.

2 hydroxylase rather than an N-methyl arginyl-demethylase.

3 adation via Jumonji-D3 (JMJD3/KDM6B) histone demethylase.

4 ns of histone methyl transferases or histone demethylases.

5 thyladenosine (m(6)A) methyltransferases and demethylases.

6 histone marks targeted by lysine methylases/demethylases.

7 ndscape by reducing VitC for DNA and histone demethylases.

8 pression of Kdm6b/Jmjd3 and Kdm6a/Utx, H3K27 demethylases.

9 e exquisitely dependent on the enzyme lysine demethylase 1 (Kdm1a/Lsd1).

10 iption factor (REST)-lysine-specific histone demethylase 1 (LSD1) co-repressor complex associates wit

11 The lysine specific demethylase 1 (LSD1) demethylates at both of these lysin

12 Lysine-specific demethylase 1 (LSD1) expression is inappropriately upreg

13 s that expression of histone lysine-specific demethylase 1 (LSD1) is inversely associated with the le

14 t knockout of KDM1A encoding lysine-specific demethylase 1 (LSD1) sensitizes DIPG cells to histone de

15 Lysine-specific demethylase 1 (LSD1) targets cellular proteins, includin

16 Here, we report that lysine-specific demethylase 1 (LSD1) upregulates hypoxia responses by de

17 nserved histone demethylase, lysine-specific demethylase 1 (LSD1), regulates heterochromatin in Neuro

18 Lysine-specific demethylase 1 (LSD1), which has been considered as a pot

19 n GFI1B's obligate effector, lysine-specific demethylase 1 (LSD1).

20 sensitivity to inhibitors of lysine-specific demethylase 1 (LSD1).

21 Here, we show that lysine-specific demethylase 1 (LSD1; also known as KDM1A), a histone dem

22 GSK2879552, a lysine demethylase 1 inhibitor currently in clinical trials for

23 bioavailable first-in-class lysine-specific demethylase 1 inhibitor.

24 Lysine specific demethylase 1 KDM1A (LSD1) regulates histone methylation

25 nd that LASER binds to LSD1 (lysine-specific demethylase 1), a member of CoREST/REST complex, in nucl

26 priming mechanism involving LYSINE-SPECIFIC DEMETHYLASE 1-LIKE 3 (LDL3) specifically eliminates H3K4

27 ides as an H3K4 demethylase, lysine-specific demethylase-1 (LSD1) has been shown to promote H3K9 deme

28 Lysine-specific histone demethylase 1A (LSD1 also known as KDM1A) inhibitors wer

29 epigenetic regulator lysine-specific histone demethylase 1A (LSD1) induces a rapid expansion of human

30 Here, we report that lysine-specific demethylase 2 (LSD2) regulates the expression of genes a

31 dopsis JHDM2 (JmjC domain-containing histone demethylase 2) family protein, which modulates defense a

32 Lysine-specific demethylase-2 is distinctively involved in brown and bei

33 The lysine-specific demethylase 2A gene (KDM2A) is ubiquitously expressed an

34 We demonstrated that lysine demethylase 3A (KDM3A) binds to PGC-1alpha and demethyla

35 The histone lysine demethylase 3A (KDM3A) demethylates H3K9me1 and H3K9Me2

36 Lysine-specific demethylase 4A (KDM4A) demethylates H3K9me3 at promoters

37 In mice, lysine demethylase 4B is expressed during brain development wit

38 icantly decreased ARID3A, ARID3B, and lysine demethylase 4C (KDM4C).

39 Here, we show that lysine demethylase 5 (KDM5) is essential for prothoracic gland

40 the regulation of MPC-1 expression by Lysine demethylase 5A (KDM5A) and critical impact of this novel

41 f one of the JmjC-containing enzymes, lysine demethylase 5A (KDM5A), mimics hypoxia-induced cellular

42 KDM5B (lysine[K]-specific demethylase 5B) is frequently upregulated in various hum

43 Lysine demethylase 6A (KDM6A), also known as UTX, belongs to th

44 PDAC), while KDM6A, encoding Lysine-specific demethylase 6A, carries somatic mutations in PDAC.

45 ten-eleven translocation (TET) family of DNA demethylases(7).

46 Here, we report that lysine demethylases 7A (KDM7A) and 6A (UTX) play crucial roles

47 get [Acanthamoeba castellanii sterol 14alpha-demethylase (AcCYP51)] formed a dimer via an N-termini s

48 followed exponential decay, suggesting H3K36 demethylases act in a global, stochastic manner.

49 Functional redundancy between H3K27 demethylase activities of KDM6A and KDM6B in vivo has ye

50 Specifically, DFP inhibits the demethylase activities of six KDMs - 2A, 2B, 5C, 6A, 7A

51 e expression that was independent of histone demethylase activity and linked to histone phosphorylati

52 We find that N-demethylase activity can be readily observed on substrat

53 Selective inactivation of demethylase activity eliminates H4K20me1 enrichment in s

54 We demonstrate that dKDM4A demethylase activity is dispensable for PEV.

55 NO66 suppression of ribosomal biogenesis via demethylase activity is the mechanism behind these respo

56 Moreover, H3K4 demethylase activity of JMJ17 was required for dehydrati

57 The in vitro demethylase activity of KDM5A is allosterically enhanced

58 reveal that the histone H3 lysine 36 (H3K36) demethylase activity of the CGI-binding KDM2 proteins co

59 e studies) actually retains substantial H3K4 demethylase activity on nucleosome substrates.

60 flavin adenine dinucleotide (FAD) to inhibit demethylase activity, SP-2509 has previously been shown

61 SCF to the Akt complex, independently of its demethylase activity, thereby initiating K63-linked ubiq

62 We demonstrate that UTX, in a demethylase activity-independent manner, facilitates con

63 d to FTO and selectively inhibit FTO's m(6)A demethylase activity.

64 s the inhibitory effect of Deltex2 on Jmjd1c demethylase activity.

65 s Jmjd1c monoubiquitination and inhibits its demethylase activity.

66 Y and functions largely independently of its demethylase activity.

67 igenesis in vivo, both of which required FTO demethylase activity.

68 om Prevotella sp. P5-125 (dPspCas13b) to m6A demethylase AlkB homolog 5 (ALKBH5).

69 ent of size-selected (<200 nt) RNAs with the demethylase AlkB to remove major tRNA modifications, fol

70 en hTR and the N (6)-methyladenosine (m(6)A) demethylase ALKBH5 and showed that ALKBH5 is able to era

71 tly identify the essential function of m(6)A demethylase ALKBH5 in maintaining myeloid leukemia stem

72 We show that the m(6)A demethylase ALKBH5 is highly expressed in glioblastoma s

73 Here we show that expression of m(6)A demethylase ALKBH5 is regulated by chromatin state alter

74 Here, we show that deletion of the m(6)A demethylase Alkbh5 sensitized tumors to cancer immunothe

75 ally, the m(6)A methyltransferase METTL3 and demethylases ALKBH5 mediate the m(6)A modification in 3'

76 ajor m(6)A methyltransferase complex), m(6)A demethylases (ALKBH5 and FTO), or m(6)A reader proteins

77 As an m(6)A demethylase, ALKBH5 has been shown to promote the develo

78 Discoveries of RNA demethylases, along with advances in mass spectrometry a

79 ENE-INSENSITIVE6 (EIN6), which is a H3K27me3 demethylase also known as RELATIVE OF EARLY FLOWERING6 (

80 LSD1 (lysine specific demethylase; also known as KDM1A), the first histone dem

81 enase activities, acting as both an arginine demethylase and a lysyl-hydroxylase.

82 ji C domain-containing (JMJD) 1 A, a histone demethylase and epigenetic regulator involved in colorec

83 KDM3B encodes for a histone demethylase and is involved in H3K9 demethylation, a cru

84 ssor complex with a histone H3K9Me2-specific demethylase and promote adipogenesis and smooth muscle d

85 ding IBM1 encoding an essential H3K9 histone demethylase and the disease resistance gene RECOGNITION

86 haracterized as a euchromatic histone H3 K36 demethylase and transcriptional regulator, predominantly

87 romatin-modifying enzymes, including histone demethylases and the Tet family of enzymes that are invo

88 y m(6)A methyltransferases, removed by m(6)A demethylases, and recognized by different reader protein

89 In addition to HIFs, multiple histone demethylases are altered in their expression and activit

90 Our results reveal that JMJD2 demethylases are potential therapeutic targets to overco

91 ken together, our results show that the KDM4 demethylases are required for the expression of genes es

92 CYP51 enzymes (sterol 14alpha-demethylases) are cytochromes P450 that catalyze multist

93 rotonin signalling, identifying this histone demethylase as a potential target for the treatment of a

94 for their further study and validate 14alpha-demethylase as the target for azoles in Acanthamoeba.

95 cting factors such as methyltransferases and demethylases, as well as previously reported and novel h

96 ationale for nonredundant roles of these RNA demethylases beyond different substrate preferences and

97 This work defines LigM as a distinct demethylase, both structurally and functionally, and pro

98 :eaau2922) shows that inhibition of the LSD1 demethylase can induce derepression of NOTCH receptor ge

99 such as histone deacetylases, methylases and demethylases, can elicit similar effects either individu

100 The 2-OGDD histone demethylases control histone methylation.

101 t, a dimeric methyltransferase and monomeric demethylase cooperate to eliminate asymmetry and focus s

102 Jmjd2 H3K9 demethylases cooperate in promoting mouse embryonic stem

103 erived from inhibition of lanosterol 14alpha-demethylase (CYP51) in the endogenous sterol synthesis p

104 Sterol 14alpha-demethylase (CYP51) is a cytochrome P450 enzyme required

105 Sterol 14alpha-demethylase (CYP51) is a target for antifungal drugs kno

106 Sterol 14alpha-demethylases (CYP51) are the cytochrome P450 enzymes req

107 partial redundancy with UTY, a Y-chromosome demethylase-dead homolog.

108 These findings are substantiated through demethylase-dead knockin mutation of UTX, which supports

109 muscle cells, expression of NO66, but not of demethylase-dead mutant NO66, decreased H3K4me3 and H3K3

110 of host-commensal bacteria homeostasis in a demethylase-dependent manner.

111 in this study, KDM8/JMJD5, a histone lysine demethylase/dioxygnase, exhibits a novel property as a d

112 ase; also known as KDM1A), the first histone demethylase discovered, regulates cell-fate determinatio

113 In most cases, DMSP lyases and DMSP demethylases (DmdAs) have low substrate affinities, but

114 the activation of alphaKG-dependent histone demethylases, enhancing chromatin accessibility in loci

115 ate can be used as additives to inhibit TMAO-demethylase enzyme during frozen storage of fish minces.

116 thetic pathway via inhibition of the 14alpha-demethylase enzyme present in fungal cells.

117 n tea extracts, phytic acid) to inhibit TMAO-demethylase enzyme was assayed.

118 TMAO-demethylase enzyme was partially inhibited (lower enzyme

119 lating the phosphorylation status of histone demethylase enzymes in response to SAM levels.

120 activities of histone methyltransferase and demethylase enzymes to set the methylation status of the

121 ass of molecular dioxygenases is the histone demethylase enzymes, which are characterized by the pres

122 nes through hyperphosphorylation of specific demethylase enzymes.

123 on of this paradigm where a putative histone demethylase Epe1 in fission yeast, has a non-enzymatic f

124 ugh cell division provided the counteracting demethylase Epe1 is absent(4,5).

125 The discovery of FTO as the first m6A mRNA demethylase established the concept of reversible RNA mo

126 g cells with high Notch activity and histone demethylase expression are present in primary glioblasto

127 emerging targeted inhibitors of this histone demethylase family in cancer therapy.

128 ciency of ten-eleven translocation (Tet) DNA demethylase family members Tet2 and Tet3 in B cells led

129 e, we show that JMJD1C is a specific histone demethylase for lipogenic gene transcription in liver.

130 y, we identify LSD1 as a major counteracting demethylase for Setd1a and show that its pharmacological

131 transferase, TRMT10A, interacts with an mRNA demethylase FTO (ALKBH9), both in vitro and inside cells

132 A new tumor suppressor function of the RNA demethylase FTO implicates m(6)A RNA modifications in th

133 al interaction between VHL and the m(6)A RNA demethylase FTO in renal cell carcinoma.

134 ibe two small-molecule inhibitors of the RNA demethylase FTO that demonstrate significant anti-tumor

135 %) upon in vitro demethylation by the m(6) A demethylase FTO with high reproducibility.

136 criptional mark can be "erased" by the m(6)A demethylase FTO, which is commonly deregulated in acute

137 Mechanistically, downregulation of m(6)A demethylases FTO and ALKBH5 was sufficient to increase F

138 ining the role of the best characterized RNA demethylase, FTO (fat mass and obesity-associated) in me

139 xamined the contribution of Kdm6a, a histone demethylase gene known to escape X inactivation.

140 of OCT4 to the promoter of Kdm2b, a histone demethylase gene that promotes reprogramming by reactiva

141 d EV71 replication, whereas knockdown of the demethylase had the opposite effect.

142 d gene expression whereas knockdown of m(6)A demethylases has the opposite effect.

143 Recently, lysine-specific demethylases have been identified as a potential, attrac

144 ysine methyltransferases, and histone lysine demethylases, have a role in diverse cancers, specific m

145 enzymes can act as both direct and indirect demethylases, highlight the active-site plasticity of th

146 Since its identification as an H3K27 demethylase in 2007, studies have reported KDM6A's criti

147 emonstrate a crucial role of FTO as an m(6)A demethylase in promoting melanoma tumorigenesis and anti

148 Pharmacologic inhibition of H3K27-demethylases in human chordoma cells promotes epigenetic

149 and plasticity of cytochrome P450 aromatic O-demethylases in the biological conversion of lignin-deri

150 sion of known histone methyltransferases and demethylases in three NSCLC cell lines with or without a

151 Our results suggest that m(6)A demethylases in tumor cells contribute to the efficacy o

152 MJ14, a Jumonji (JMJ) domain-containing H3K4 demethylase, in local and systemic plant immune response

153 Ciclopirox targeted several histone demethylases, including KDM4B implicated in MYC function

154 Together this reveals a demethylase-independent role for KDM2 proteins in transc

155 ver that KDM2 proteins play a widespread and demethylase-independent role in constraining gene expres

156 egulation of beige adipocytes is largely DNA demethylase-independent.

157 Here we show that multiple histone demethylases influence the viability and poor prognosis

158 d preadipocytes, the levels of KDM5C histone demethylase influenced chromatin accessibility (ATAC-Seq

159 Histone lysine demethylase inhibition (GSK-J1, 2,4-PDCA) decreased colo

160 ory cell subsets toward a resting state upon demethylase inhibition.

161 sensing by chromatin occurs via JmjC-histone demethylase inhibition.

162 ther demonstrated that a pan jumonji histone demethylase inhibitor, JIB-04, inhibits MINA53-mediated

163 ngal agent ciclopirox as a novel pan-histone demethylase inhibitor.

164 T as a potential therapeutic target of H3K27 demethylase inhibitors in chordoma.

165 igatory cofactor for various histone and DNA demethylases involved in pluripotency.

166 Lanosterol 14-alpha demethylase is a key enzyme intermediating the biosynthe

167 osophila melanogaster KDM4A (dKDM4A) histone demethylase is required for heterochromatic DSB mobility

168 t pharmacological inhibition of KDM5 histone-demethylases is a new strategy for the personalized trea

169 Here, we show that KDM5C, encoding a H3K4 demethylase, is at the intersection of transcriptional a

170 ase 1 (LSD1; also known as KDM1A), a histone demethylase, is essential to this process.

171 tous in organisms, however the roles of H3K4 demethylase JARID1(Jar1)/KDM5 in fungal development and

172 mes are subject to phosphorylation, although demethylases Jhd1p and Jhd2p contained one and five site

173 es (Set1p, Set2p, Set5p, and Dot1p) and four demethylases (Jhd1p, Jhd2p, Rph1p, and Gis1p).

174 inases of RNAP II (Bur1 and Ctk1), a histone demethylase (Jhd2), and a mutated form of a nucleosome-r

175 n wild-type yeast, deletion of the sole H3K4 demethylase, Jhd2, has no effect.

176 pitulated by removal of the putative H3K9me2 demethylase JHDM-1.

177 Here, we document that a histone demethylase, JMJ17, belonging to the KDM5/JARID1 family,

178 re, we reveal an adaptor function of histone demethylase JMJD2A, which is important for recognizing A

179 ent of histone methylase (COMPASS)-, histone demethylase (Jmjd2a/Jmjd3)-, and SWI/SNF-containing comp

180 We show that the histone demethylase JMJD2B is induced by EndMT-promoting, proinf

181 tion is critically controlled by the histone demethylase JMJD2B, which is induced by EndMT-promoting,

182 Additionally, inhibition of the H3K27 demethylase JMJD3 in naive CD4 T cells demonstrates how

183 xpression of the histone 3 lysine 27 (H3K27) demethylase Jumonji d3 (Jmjd3), which thereby controls t

184 ant proportion affecting genes of the lysine demethylase (KDM) family.

185 succinate metabolism, including TET2, lysine demethylase (KDM) KDM6A, BRCA1-associated BAP1, and citr

186 Recently, we showed that lysine demethylase KDM1A is overexpressed in GBM.

187 binding of inhibitors to the histone lysine demethylase KDM1A.

188 is mediated by interaction with the histone demethylase KDM1A/LSD1.

189 lysis of chromatin recognition by the lysine demethylase KDM2A.

190 Here we identified that the lysine-specific demethylase KDM3A played a dual role in breast cancer ce

191 The H3K9me2 demethylase, Kdm3b, transcriptionally controls DNA hydro

192 Histone Lys demethylase KDM3C demonstrates anti-inflammatory effects

193 in epigenetic regulators such as the lysine demethylase KDM4.

194 In conditions where the histone demethylase KDM4A is depleted or inactive, H3K9me3 accum

195 promoter regions and recruiting the histone demethylase Kdm4a to remove repressive histone marks.

196 ometabolite-induced inhibition of the lysine demethylase KDM4B results in aberrant hypermethylation o

197 , which is antagonized by the Jumonji-family demethylase KDM4B.

198 n in part through its binding to the histone demethylase KDM5A (also known as RBP2 or JARID1A).

199 we report the identification of the histone demethylase KDM5A as a key regulator of the bromodomain

200 Histone demethylase KDM5A removes methyl marks from lysine 4 of

201 showed that AW112010 interacted with histone demethylase KDM5A, which led to decreased H3K4 methylati

202 Loss-of-function mutations in the histone demethylases KDM5A, KDM5B, or KDM5C are found in intelle

203 2984 also promoted the expansion of the H3K4 demethylase KDM5B (also known as JARID1B)-positive subpo

204 Histone lysine demethylase KDM5B (PLU-1) catalyzes the demethylation of

205 es Ash1l, Smyd2, and Ezh2 and histone lysine demethylases Kdm5b and Kdm6b in J774 macrophages and BAL

206 Here, we unraveled the metabolome of an H3K4 demethylase (KDM5B/JARID1B)-driven melanoma cell phenoty

207 ncers show TF-dependent binding of the H3K27 demethylase KDM6A.

208 DINO expression is regulated by the histone demethylase KDM6A.

209 acts with histone chaperone SPT6 and histone demethylase KDM6A.

210 We found that the H3K27 histone demethylase KDM6A/UTX, but not its paralog KDM6B, is oxy

211 ologic inhibition of the histone 3 lysine 27 demethylases KDM6A (UTX) and KDM6B (JMJD3) leads to cell

212 -genetic approach, we identify histone H3K27 demethylases KDM6A and KDM6B as central regulators of hu

213 In contrast, knockdown of the H3K27 demethylases Kdm6A and Kdm6B restored the levels of H3K2

214 by activation of p65 and requires a histone demethylase KDM6B.

215 one of which encodes the histone H3K36(me2) demethylase Kdm8.

216 Histone lysine demethylases (KDMs) are involved in the dynamic regulati

217 Histone lysine demethylases (KDMs) are of critical importance in the ep

218 lysine methyltransferases (KMTs) and lysine demethylases (KDMs) have been implicated in the differen

219 dy, in silico analyses of the lysine histone demethylases (KDMs) involved in diverse biological proce

220 Histone Lys-specific demethylases (KDMs) play a key role in many biological p

221 rotein methyltransferases (PMTs) and histone demethylases (KDMs) play an important role in the regula

222 es of selected iron-dependent histone lysine demethylases (KDMs), resulting in pan inhibition of a su

223 D histone methylase (KS1) or the UTX histone demethylase (KS2).

224 The knockout of the KDM4 demethylases leads to accumulation of H3K9me3 on transcr

225 system, the tetrahydrofolate-dependent aryl demethylase LigM from Sphingomonas paucimobilis, a bacte

226 ions of epigenetic enzymes including histone demethylase LSD1 and histone acetyltransferase Tip60.

227 quently, Phf21b recruits the lysine-specific demethylase Lsd1 and histone deacetylase Hdac2, resultin

228 ling environment and activity of the histone demethylase LSD1 during differentiation of hESC-gut tube

229 a potential role for the histone H3 lysine 4 demethylase LSD1 in regulating PD-1 expression.

230 n of hepatic autophagy by recruiting histone demethylase LSD1 in response to a late fed-state hormone

231 ously, our laboratory implicated the histone demethylase LSD1 in tau-induced neurodegeneration by sho

232 The histone demethylase LSD1 is an epigenetic modifier that promotes

233 omotes lipogenesis by recruiting the histone demethylase Lsd1 to the fatty acid synthase gene promote

234 histone deacetylases HDAC1/2 and the histone demethylase LSD1, enzymes that also participate in Cd4 s

235 etically requires FLD, a homolog of the H3K4 demethylase LSD1.

236 cells, here we inducibly delete the histone demethylase LSD1/KDM1A in adult mice.

237 Histone demethylase LSDl (KDMlA) belongs to the flavin adenine d

238 We explored whether the conserved histone demethylase, lysine-specific demethylase 1 (LSD1), regul

239 Besides as an H3K4 demethylase, lysine-specific demethylase-1 (LSD1) has be

240 ysine 4 (H3K4) methyltransferase and histone demethylase maintain a dynamic and homeostatic state of

241 This suggests that inhibiting KDM6 demethylases may be an effective, even in the short term

242 hat epigenetic regulators, including histone demethylases, may control the cell-to-cell variability o

243 gRNA screens, we identified that the histone demethylase, MINA53, is potentially a novel HIV-1 latenc

244 hylation (RdDM) pathway mutants and a triple demethylase mutant; here we demonstrate that the disrupt

245 Here, we explored the role of histone demethylase NO66 in the pathogenesis of PCa and bone met

246 nd localization of the methyltransferase and demethylase of m6A, and its binding proteins.

247 yladenosine (m1A) and 3-methylcytidine (m3C) demethylase of tRNA.

248 TET enzymes are also proficient as direct N-demethylases of cytosine bases.

249 mbers, FTO and ALKBH5, both act as oxidative demethylases of N6-methyladenosine (m6A) but furnish dif

250 alian writer (methyltransferase) and eraser (demethylase) of the DNA N6-methyladenine (N6mA) methyl m

251 sexually dimorphic gene was Kdm6a, a histone demethylase on the X chromosome.

252 ther this is a direct effect on JmjC-histone demethylases or due to other mechanisms is unknown.

253 ther this reflects direct effects on histone demethylases or indirect effects caused by the hypoxic i

254 histone lysine methyltransferases and lysine demethylases orchestrate these events, their role remain

255 t of the Jumonji C domain-containing histone demethylase PHF2 for epigenetic activation of these prom

256 Here, we demonstrate that the H3K9me2 demethylase PHF2 is essential for neural progenitor prol

257 Histone demethylase PHF8 is upregulated and plays oncogenic role

258 c interaction between TopBP1 and the histone demethylase PHF8.

259 re we report that the KDM3 family of histone demethylases plays an important role in tumorigenic pote

260 Here we show that FTO, as an m(6)A demethylase, plays a critical oncogenic role in acute my

261 mass and obesity-associated protein), an m6A demethylase, plays a critical role in cardiac contractil

262 n (FTO), an RNA N(6)-methyladenosine (m(6)A) demethylase, plays oncogenic roles in various cancers, p

263 Here, we describe pyocyanin demethylase (PodA), a hitherto uncharacterized protein t

264 ration of 2-hydroxyglutarate, which inhibits demethylase reactions to modulate cell fate and function

265 es and biochemical properties of bacterial N-demethylases remain largely unknown.

266 ransferases add a methyl group to mRNA while demethylases remove methyl groups.

267 nd NdmB, the initial N(1)- and N(3)-specific demethylases, respectively.

268 addition sites with synonymous mutations or demethylase resulted in m(6)A-deficient recombinant HMPV

269 d expression of the methyltransferase and/or demethylases results in developmental defects and cancer

270 of the transgene d35S::LUC, although the DNA demethylase ROS1 is also required for d35S::LUC anti-sil

271 PP2A methyltransferase or the effector H3K36 demethylase Rph1 exhibit elevated SAM levels and are dep

272 oval of H3K36me3 was highly dependent on the demethylase Rph1.

273 ers and other regulatory regions by specific demethylase(s) generates reactive oxygen species (ROS),

274 In turn, aKG mediated activation of the demethylase TET enzyme led to decreased cytosine methyla

275 The DNA demethylase TET1 is highly expressed in embryonic stem c

276 t subcutaneous adipose expression of the DNA demethylase TET1 is suppressed by cold and other stimula

277 any of the NONO regulated genes are also DNA demethylase TET1 targeted genes.

278 urther demonstrated that EGR1 recruits a DNA demethylase TET1 to remove the methylation marks and act

279 axon regeneration and vision require the DNA demethylases TET1 and TET2.

280 ity-associated gene (FTO) encodes an m6A RNA demethylase that controls mRNA processing and has been l

281 Utx is an H3K27 demethylase that influences adipocyte function in vitro.

282 LSD1 (KDM1A) is a histone demethylase that plays both oncogenic and tumor suppress

283 ion of LSD1 in AD and FTD."LSD1 is a histone demethylase that plays many roles during development.

284 S3 encodes a putative Jumonji C-type histone demethylase that regulates expression of other VRS genes

285 However, the histone demethylase that specifically controls histone methylati

286 osome X (UTX, encoded by KDM6A) is a histone demethylase that targets di- and tri-methylated histone

287 JARID1 proteins are histone demethylases that both regulate normal cell fates during

288 JMJD2s are a family of histone demethylases that remove tri-methyl groups from H3K9 and

289 s specific histone lysine methyltransferases/demethylases to redirect epigenetic programming of M(LPS

290 In contrast, knockdown of the H3K27 demethylase ubiquitously transcribed tetratricopeptide r

291 ults demonstrate a new function of a histone demethylase under dehydration stress in plants.

292 Here, we focus on loss of the histone demethylase UTX (also known as KDM6A) and activation of

293 Of all genes tested, KDM3B, a histone H3K9 demethylase, was found to have the most antiproliferativ

294 FTO, an mRNA N(6)-methyladenosine (m(6)A) demethylase, was reported to promote leukemogenesis.

295 opens a potential and novel paradigm of tRNA demethylase, which regulates biological functions via ge

296 KDM6 family of histone H3 lysine 27 (H3K27) demethylases, which also includes UTY and KDM6B (JMJD3).

297 KDM4/JMJD2 are H3K9- and H3K36-specific demethylases, which are considered promising therapeutic

298 KDM4B is a lysine-specific demethylase with a preferential activity on H3K9 tri/di-

299 obesity-associated protein (FTO) is an m(6)A demethylase with oncogenic properties in leukemia.

300 Constitutive association of demethylases with BER/SSBR proteins in multiprotein comp