ライフサイエンスコーパス: demethylation

1 oxp3-transcriptional activation elicits CNS2 demethylation.

2 hieved by the coupling of active and passive demethylation.

3 , but not protein expression, abolishes CNS2 demethylation.

4 ed 5mC derivatives and initiating active DNA demethylation.

5 e SIZ1 as a critical regulator of active DNA demethylation.

6 ently those that mediate histone methylation/demethylation.

7 suppressing IL-10 expression through histone demethylation.

8 in competitive inhibition of DNA and protein demethylation.

9 es that occurs as intermediate of active DNA demethylation.

10 a similar safety profile and dose-dependent demethylation.

11 mESCs show no involvement of epigenetic DNA demethylation.

12 ing methyl position specificity for proper N-demethylation.

13 ated in VCs, mostly by DEMETER-catalyzed DNA demethylation.

14 etter understand electron transport during N-demethylation.

15 zed methylcytosines are intermediates in DNA demethylation.

16 escribed anoxic mechanism of proline betaine demethylation.

17 orming the last of the multiple steps in DNA demethylation.

18 minal tail peptides have a similar effect on demethylation.

19 actors are due to DNA damage or impaired DNA demethylation.

20 ain and improves the catalytic efficiency of demethylation.

21 epair of oxidative lesions and in epigenetic demethylation.

22 t family of enzymes that are involved in DNA demethylation.

23 lase-1 (LSD1) has been shown to promote H3K9 demethylation.

24 stream of the JmjC domain do not disrupt UTX demethylation.

25 methylcytosine (5hmC), which can lead to DNA demethylation.

26 ing the female pronucleus from TET3-mediated demethylation.

27 -regulating Tet1 and Tet2, which promote DNA demethylation.

28 A101.3, lacking the structural liability for demethylation.

29 ion (TET) family members regulate active DNA demethylation.

30 DNA glycosylase ROS1, which facilitates DNA demethylation.

31 xidize 5mC on DNA could mediate KIR promoter demethylation.

32 droxylation, epoxidation, sulfoxidation, and demethylation.

33 TET2 catalyzes DNA demethylation.

34 tosine (5hmC), thereby initiating active DNA demethylation.

35 tability and positively regulates active DNA demethylation.

36 ian disorder caused by the disruption of DNA demethylation.

37 transcripts to FLD/LD/SDG26-associated H3K4 demethylation.

38 by modulating chromatin architecture and DNA demethylation.

39 tion of slug and CD87 gene by their promoter demethylation.

40 DNA to recognize all four bases involved in demethylation.

41 escribed mechanism of biological l-carnitine demethylation.

42 demonstrate that MtcB catalyzes l-carnitine demethylation.

43 ase, supporting a role for ICU11 in H3K36me3 demethylation.

44 e mammalian germline undergoes extensive DNA demethylation(3-7) that occurs in large part by passive

45 histone demethylase and is involved in H3K9 demethylation, a crucial part of chromatin modification

46 lation of key BER proteins during active DNA demethylation-a role they demonstrate to be important fo

47 MeHg exported from upstream wetlands due to demethylation, absorption, deposition, and degradation b

48 Consequently, rather than methylation and demethylation acting in opposition as logic would sugges

49 ppo activators RASSF1 and RASSF5 by promoter demethylation, activating canonical Hippo signaling and

50 srupted when parasites were treated with the demethylation activator ascorbic acid.

51 The demethylation activity of atALKBH9B affected the infecti

52 This is performed by the demethylation activity of FTO, which selectively demethy

53 namic connection between FTO RNA binding and demethylation activity that influences several mRNA proc

54 ned to compare systemic decitabine exposure, demethylation activity, and safety in the first 2 cycles

55 Treatment of glioblastoma cells with a demethylation agent results in both increased TE express

56 In late gestation, genome-wide H3K27 demethylation allowed for target gene upregulation, deci

57 n by coordinating efficient TDG-mediated DNA demethylation along with active transcription during som

58 Structure-activity analysis revealed that N-demethylation alters the interaction of PK11195 with the

59 n by ten-eleven translocation (TET)-mediated demethylation and a concomitant increase of accessibilit

60 al fibrillary acidic protein (GFAP) promoter demethylation and a striking lengthening of the G1 cell

61 sh histone methylation, and increase histone demethylation and acetylation at histone 3 lysine 27 (H3

62 romoter, Oplr16 recruited TET2 to induce DNA demethylation and activate Oct4 in fibroblasts, leading

63 ent utilization of LigM as a tool for aryl O-demethylation and as a component of synthetic biology ef

64 KDM6A loss, like hypoxia, prevented H3K27 demethylation and blocked cellular differentiation.

65 a functional relationship between active DNA demethylation and chromatin structure is often implied,

66 corbic acid (AA) treatment caused genomewide demethylation and enhanced expression of endogenous retr

67 of genomic integrity but also in active DNA demethylation and epigenetic gene regulation.

68 underscores the coordination of histone/DNA demethylation and genome repair during gene activation.

69 hich in turn can be further amplified by DNA demethylation and histone deacetylase inhibitors providi

70 he P2 promoter by FOXA2, leading to promoter demethylation and increased transcription.

71 and functionally, and provides insight into demethylation and its reaction requirements.

72 s to PARP inhibition by antagonizing histone demethylation and obscuring epigenetic marks that are ne

73 otein (KZFP) ZFP57 protects select ICRs from demethylation and preserves parental identity.

74 Impaired DNA demethylation and reduced chromatin accessibility in Tet

75 aternal vitamin C is required for proper DNA demethylation and the development of female fetal germ c

76 h the known functions of TET proteins in DNA demethylation and the known distribution of 5hmC at tran

77 tically, peripheral nerve injury induces DNA demethylation and upregulation of multiple regeneration-

78 sed H1 suppresses TEs in VCs by reducing DNA demethylation and via a methylation-independent mechanis

79 fector proteins, induce their methylation or demethylation, and alter their conformation.

80 ed similar systemic decitabine exposure, DNA demethylation, and safety vs decitabine 20 mg/m2 IV in t

81 C-Seq incorporates small RNA selection, AlkB demethylation, and sodium borohydride reduction steps to

82 We propose this demethylation antagonizes an active transcription module

83 ria and proteasome, mitochondria and histone demethylation, as well as ribosomes and lipid biosynthes

84 e, decreases in 5mCG + 5hmCG (5hmCG-mediated demethylation) associate with gene activation.

85 Demethylation associates with increased gene expression,

86 Here, we report that KDM4A-mediated H3K9me3 demethylation at bdH3K4me3 in oocytes is crucial for nor

87 ic activity of LSD1 is essential for H3K9me2 demethylation at cell cycle gene loci.

88 Early DNA demethylation at certain enhancers prospectively marks c

89 We found that ThymoD transcription promoted demethylation at CTCF bound sites and activated cohesin-

90 Ascl1 induces local demethylation at its binding sites.

91 This effect correlated with rapid DNA demethylation at reprogramming enhancers and increased c

92 -activator), that together produced complete demethylation at the conserved noncoding sequence 2 (CNS

93 ng temporally specific changes in active DNA demethylation at the promoter of plasticity-related IEGs

94 he recruitment of Gadd45gamma and active DNA demethylation at the same site, which is necessary for m

95 eficient cells, including reproducible focal demethylation at thousands of normally methylated loci.

96 Differences in mean %LINE-1 demethylation between oral and IV were <=1%.

97 Genetic and pharmacological DNA demethylation, but also cancer-associated DNA hypomethyl

98 erences and cellular localization, where m6A demethylation by ALKBH5 versus FTO results in release of

99 t TET2, a cellular enzyme that initiates DNA demethylation by converting 5-methylcytosine (5mC) into

100 DPPA3 in turn drives large-scale passive demethylation by directly binding and displacing UHRF1 f

101 show that N(6)-methyladenosine (m(6)A) mRNA demethylation by fat mass and obesity-associated protein

102 containing consensus m6A motifs required for demethylation by Fto Fto KO osteoblasts were more suscep

103 en-eleven translocation), which promotes DNA demethylation by oxidizing 5-methylcytosine (5mC) to 5-h

104 ve cell divisions, accompanied by active DNA demethylation by TET enzymes(3,8-10).

105 al methylation levels (0-84 %) upon in vitro demethylation by the m(6) A demethylase FTO with high re

106 Our results show that KIR promoter demethylation can be induced in CD56(bright), and this p

107 source by degrading it through sequential N-demethylation catalyzed by five enzymes (NdmA, NdmB, Ndm

108 rably different biogeochemical implications: demethylation channels sulfur into the microbial food we

109 In the germline, promoter DNA demethylation coincides with expression of Dppa2 and Dpp

110 exogenous source of alphaKG restored the DNA demethylation cycle by promoting TDG function, TET1 nucl

111 The observed sequential methylation/demethylation cycle suggests an important role of DNA me

112 d by enzymatic reactions including oxidative demethylation/deamination and myeloperoxidation, it is u

113 Demethylation-dependent CTCF binding to both promoters f

114 Demethylation depends on TET expression and occurs only

115 destabilize this domain (ligand binding and demethylation) disfavor CheA binding such that it loses

116 To understand how CpG demethylation downstream of SALL4 TSS regulates SALL4 tr

117 ethylcytosine dioxygenase that initiates DNA demethylation during early zygote formation, embryogenes

118 of balance between cytosine methylation and demethylation during the circadian cycle can be a potent

119 an obligate by-product of oxidative protein demethylation during transcription regulation.

120 ndogenous retrovirus (ERV)3-1, with promoter demethylation, enhanced chromatin accessibility, and inc

121 rsion into induced Tregs with increased TSDR demethylation, enhanced stability, and suppressive activ

122 tivation in induced Tregs also promotes CNS2 demethylation, enhancing Treg lineage stability and supp

123 Lost expression of a key DNA demethylation enzyme TET2 is associated with human cance

124 DNA demethylation facilitated CCCTC-binding factor (CTCF) re

125 sis or repressing alpha-ketoglutarate-driven demethylation facilitates malignant progression.

126 FOXH1 expression by NANOG, LIN28, and H3K79 demethylation for dramatic enhancement of reprograming.

127 interspersed nuclear element 1 (LINE-1) DNA demethylation for oral cedazuridine/decitabine vs IV dec

128 T cell-specific demethylation region (TSDR) demethylation, FOXP3 expression, and suppression were an

129 Uncoupling DNA demethylation from antisense transcription by Tet3 overe

130 s, antisense transcription-mediated promoter demethylation functions as a mechanism for distance-inde

131 Oxidative demethylation gave targeted benzimidazolequinones, inclu

132 but only at high concentrations (>1 muM for demethylation; >35 nM for cleavage), characteristic of m

133 nally suppressed the expression of MPC-1 via demethylation H3K4.

134 The elucidation of cytosine demethylation has drawn added attention the three additi

135 mark, yet no human Mendelian disorder of DNA demethylation has yet been delineated.

136 metogenesis facilitates DEMETER-directed DNA demethylation, heterochromatin relaxation, and TE activa

137 vealed critical roles of histone methylation/demethylation, histone acetylation/deacetylation, chroma

138 the balance between histone methylation and demethylation impacted growth and proliferation.

139 g et al. (2017) reveal a role for active DNA demethylation in allowing axon regeneration to occur in

140 nding of MeHg on soil organic matter, and/or demethylation in drier wetland soils.

141 ppa3 facilitated the emergence of global DNA demethylation in mammals.

142 en Foxp3-transcriptional activation and CNS2 demethylation in mice.

143 PPA3 alone is capable of inducing global DNA demethylation in non-mammalian species (Xenopus and meda

144 ygenase, an activity associated with histone demethylation in other organisms, and mutant plants show

145 resource to facilitate future studies of DNA demethylation in pathogenesis and the development of 5hm

146 novel insights into Jar1/KDM5-mediated H3K4 demethylation in regulating fungal development and patho

147 accelerator of global and locus-specific DNA demethylation in somatic and pluripotent stem cells.

148 Development-specific genes often undergo DNA demethylation in their promoter and other regions, which

149 nisms and critical functional players of DNA demethylation in this process remain largely unexplored.

150 of TET enzyme, which is responsible for DNA demethylation in UVB-exposed skin.

151 more, the biological functions of active DNA demethylation in various biological contexts have also b

152 Genome-wide DNA "demethylation" in the zygote involves global TET3-mediat

153 tumor suppressor p15(INK4B) through promoter demethylation; in turn, DNMT1 dysfunction impairs KIT ki

154 terochromatin regions are protected from DNA demethylation independently of EHMT2 and SETDB1.

155 rboxylcytosine, the last intermediate in DNA demethylation, indicating successful on-target activity.

156 We further establish that DNA demethylation induced by XPC expression in somatic cells

157 Because of limited investigation of demethylation-induced genome damage during transcription

158 f ODC1 expression elicits genome-wide LINE-1 demethylation, induction of LINE-1 transcripts and doubl

159 and 5-carboxylcytosine (5caC) are considered demethylation intermediates as well as stable epigenetic

160 ugh these oxidized forms of 5mC may serve as demethylation intermediates or contribute to transcripti

161 Active DNA demethylation involves TET-mediated stepwise oxidation o

162 Genome-wide DNA demethylation is a unique feature of mammalian developme

163 to smaller amino acids, efficient syringol O-demethylation is achieved.

164 H3K9 tri/di-demethylation is an important epigenetic mechanism respo

165 e show that sequentially ordered methylation/demethylation is critical for perfect adaptation; adapta

166 OR OF SILENCING 1 (ROS1)-mediated active DNA demethylation is critical for shaping the genomic DNA me

167 Instead, TET-mediated active demethylation is locus-specific and necessary for activa

168 d losses in methylation, suggesting that DNA demethylation is mediated by TF binding to cis-acting el

169 mouse cells, and 5-azacytidine triggered DNA demethylation is more pronounced at CpG sites with flank

170 ctivation of naive and memory cells and that demethylation is the predominant change to H3K27me3 at t

171 Histone 3 Lysine 4 (H3K4) demethylation is ubiquitous in organisms, however the ro

172 licated in hydroxymethylation and active DNA demethylation, is a key regulator of EBV latency type DN

173 1(+) , encoding an enzyme that promotes H3K9 demethylation, is deleted.

174 and regulative mechanisms of bacterial DMSP demethylation, leading to a better understanding of bact

175 d-type mESCs, whereas inhibition of H3K27me3 demethylation led to a partial rescue of the Tert(-/-) p

176 Emerging evidence suggests that active DNA demethylation machinery plays important epigenetic roles

177 xp3-transcriptional activation promotes CNS2 demethylation may facilitate the development of Treg-bas

178 mark can be actively erased via a multi-step demethylation mechanism involving oxidation by Ten-eleve

179 se of FA via an unprecedented covalent-based demethylation mechanism with direct detection of a coval

180 providing chloride for post-rate-determining demethylation/neutralization of the resulting zwitterion

181 stone modifying enzymes, DNA methylation and demethylation, nucleosome remodeling complexes and trans

182 ne-dioxygenase-2 (TET2), a key enzyme in DNA demethylation, occur in cardiovascular disease and are a

183 ts that quantitatively little methylation or demethylation occurs in cytoplasmic mRNA.

184 CYP255A1 from EP4 catalyzed the O-demethylation of 4-alkylguaiacols to 4-alkylcatechols wi

185 esized to function as an intermediate in the demethylation of 5-methylcytosine (5mC) and in the react

186 e dioxygenases are enzymes that catalyze the demethylation of 5-methylcytosine on DNA.

187 encounter allele-specific TE methylation and demethylation of aberrantly expressed young LINE-1s in n

188 ge, phase partitioning during migration, and demethylation of aromatic rings) and equilibrium process

189 mental validation provided evidence that the demethylation of both DNA and histone marks can influenc

190 Exhaustive demethylation of both permethyl ethers 6 and 7 gave the

191 Demethylation of C/EBPbeta enhancer reactivates a self-r

192 n to be highly reactive with reduced sulfur, demethylation of DMHg in the presence of sulfide has unt

193 hat dissolved sulfide and FeS(s)(m) mediated demethylation of DMHg may act as a sink for DMHg, and a

194 e provide the first experimental support for demethylation of DMHg to monomethylmercury (MMHg) in the

195 Demethylation of DNA abrogated the protective effect of

196 ed inside cells by several processes such as demethylation of DNA and proteins, amino acid metabolism

197 of additional epigenetic marks and promotes demethylation of DNA in mammals(1,2).

198 hydroxylation, playing an important role in demethylation of DNA in mammals.

199 FOXP1 form a chromatin complex that mediates demethylation of ESR1, GATA3, and FOXA1, three key genes

200 ICOS deficiency is associated with reduced demethylation of Foxp3 CNS2 and enhanced loss of Foxp3.

201 ting in dissociation of CRTC2, LSD1-mediated demethylation of gene-activation histone marks H3K4-me2/

202 Hence, the demethylation of H3K36 is linked to the pathogenesis of

203 inhibitor, JIB-04, inhibits MINA53-mediated demethylation of H3K36me3, and JIB-04 synergizes with ot

204 cancer cell lines, DFP potently inhibits the demethylation of H3K4me3 and H3K27me3, two chromatin pos

205 Mechanistically, demethylation of H3K4me3 is required for ZMYND8-NuRD bin

206 omatic DSB repair depend on dKDM4A-dependent demethylation of heterochromatic histone marks.

207 We found that dKDM4A promotes the demethylation of heterochromatin-associated histone mark

208 sine demethylase KDM5B (PLU-1) catalyzes the demethylation of histone H3 on Lys 4 (H3K4), which resul

209 cluding Tfeb, Atg7, Atgl, and Fgf21, through demethylation of histone H3K27-me3, resulting in autopha

210 LSD1 catalyzes demethylation of histone H3K9 associated with herpes sim

211 ring during transcriptional activation, only demethylation of histones and cytosine-phosphate-guanine

212 ponse to methionine starvation activates the demethylation of histones through hyperphosphorylation o

213 y recruiting LSD1 to p53, which leads to the demethylation of its C-terminal domain.

214 methylation profile that includes incomplete demethylation of key regulators of meiosis and transposa

215 osum ATCC 8486, an acetogen that can grow by demethylation of l-carnitine.

216 Here, we describe P450s that catalyze the O-demethylation of lignin-derived guaiacols with different

217 procal changes in histone lysine methylation/demethylation of M(LPS + IFN-gamma)/M(IL-10) genes is on

218 We suggest this is due to preferential demethylation of MeHg with the lighter Hg isotopes and t

219 acterial gene (arsI) responsible for aerobic demethylation of methylarsenite (MAs(III)).

220 JMJD6 is also reported to catalyze N-demethylation of N-methylated (both mono- and di-methyla

221 rly proficient in either oxidation of 5mC or demethylation of N4-methyl substituents.

222 increasing histone H3K4 methylation and DNA demethylation of numerous phosphatase-encoding genes.

223 low resolution ON-MS is used to monitor the demethylation of ONs containing 1-methyladenosine by bac

224 e, we demonstrate that MtpB catalyzes anoxic demethylation of proline betaine.

225 n in a dose-dependent manner and facilitated demethylation of proximal promoters.

226 aled a regulatory axis in which LSD1 induces demethylation of repressive histone H3 lysine 9 dimethyl

227 Consistently, forcing global DNA demethylation of SCC-TAFs with 5-AZA rescued TGFbeta1/SM

228 n by METTL3 depletion or site-specific m(6)A demethylation of selected carRNAs elevates the levels of

229 5-Aza-2'-deoxycytidine induced demethylation of several CpG nucleotides, restoring miR-

230 MSP and bisulfite sequencing indicated DNA demethylation of slug and CD87 genes.

231 ed HCCs expressing increased SALL4 exhibited demethylation of specific CpG sites downstream of SALL4

232 n of a CRISPR-Cas13b-based tool for targeted demethylation of specific mRNA.

233 tion, the dm6ACRISPR system incurs efficient demethylation of targeted epitranscriptome transcripts w

234 bly boost gene activation and methylcytosine demethylation of targeted loci.

235 ng reaction in aromatic catabolism is O-aryl-demethylation of the abundant aromatic methoxy groups in

236 s through the sense promoter, leading to DNA demethylation of the CTCF binding sites proximal to each

237 oic acid-related orphan receptor gammat, and demethylation of the forkhead box P3 (FOXP3) locus.

238 We hypothesized that targeted demethylation of the ICR2 using a transcription activato

239 This is achieved by rapid demethylation of the insulin and glucagon gene promoters

240 5-Aza-dC activated demethylation of the MEG3-DMR and expression of 14q32 mi

241 13), suggesting a higher level of microbial demethylation of the methyl-mercury pool before incorpor

242 Furthermore, TET1 controls the demethylation of the miRNA-124 promoter to modulate miR-

243 Consistently, DEL-1 enhanced the demethylation of the Treg-specific demethylated region (

244 Bisulphite sequencing revealed increased demethylation of the Treg-specific demethylation region

245 patitis C virus-related HCCs correlated with demethylation of these CpG sites.

246 Similarly, SALL4 re-expression and demethylation of these CpGs was observed in HBV replicat

247 sponse to infection is accompanied by active demethylation of thousands of CpG sites overlapping dist

248 ed in shaping the chromatin landscape during demethylation of tissue-specific enhancers, differential

249 Targeted demethylation of transcripts coding for oncoproteins suc

250 the VAV1 gene body that was correlated with demethylation of two promoter CpGs (CpG6772370/CpG677281

251 Demethylation of UCH-L1 promoter was associated with UCH

252 inate stochastic process, we find pronounced demethylation of young long interspersed element 1 (LINE

253 lguanosine (m(1)G) in tRNA, and FTO performs demethylation on N (6)-methyladenosine (m(6)A) and N (6)

254 Furthermore, DNA demethylation on such loci leads to reactivation of MLL2

255 an association between response and level of demethylation or tumor mutational profile.

256 The dmdA gene from the DMSP demethylation pathway dominated the DMSP gene pool and w

257 FTO, which follows a traditional oxidative N-demethylation pathway to catalyze conversion of m6A to h

258 t Roseobacters kinetically regulate the DMSP demethylation pathway to ensure DMSP functioning and cat

259 involved in DMSP transformation through the demethylation pathway.

260 t to be catabolized by bacteria via the DMSP demethylation pathway.

261 ly widely adopted by bacteria using the DMSP demethylation pathway.

262 se bases are known to contribute to distinct demethylation pathways, the lack of tools to uncouple th

263 Collectively, our results show that DNA demethylation plays a limited role to the establishment

264 Tet-mediated DNA demethylation plays an important role in shaping the epi

265 ough a causal involvement of DNA methylation/demethylation processes, we compared the epigenetic acti

266 utant furnishes an ALKBH5 enzyme with an m6A demethylation profile that resembles that of FTO, establ

267 amework enabling us to infer methylation and demethylation rates at 860,404 CpGs in mouse embryonic s

268 Hg was shown to be pH dependent, with higher demethylation rates at pH 9 than pH 5.

269 nt DMHg to sulfide molar ratios, we observed demethylation rates up to 0.05 d(-1).

270 iled to mediate the complete the cyclization/demethylation reaction sequence by itself.

271 e pyrazine ring via an unusual tautomerizing demethylation reaction.

272 Regulatory T cell-specific demethylation region (TSDR) demethylation, FOXP3 express

273 increased demethylation of the Treg-specific demethylation region in the Foxp3 locus in tTregs but no

274 Whether and how DNA demethylation regulates the expression of SAGs and thus

275 th RET and VEGFR2, as well the resistance to demethylation, renders NPA101.3 a potential clinical can

276 (TADs), was correlated with DNA methylation/demethylation spreading and can be linked to down-regula

277 tl1 inhibited the ability of Ascl1 to induce demethylation, suggesting a contextual regulation of tra

278 ge of human NK cell development in which DNA demethylation takes place to allow for active transcript

279 e disease are enriched in DNA regions of CpG demethylation that govern Treg cell development and func

280 ailed temporal view of H3K36 methylation and demethylation that suggests transcription-dependent and

281 reported maturation-associated Ifng promoter demethylation, the less mature phenotype of Tyk2(-/-) NK

282 Through global and site-specific demethylation, they regulate cell fate decisions during

283 These experiments demonstrate that DNA demethylation through 5fC/5caC has roles distinct from 5

284 der chromatin structure regulates active DNA demethylation through TDG and provides novel insights in

285 ence somatic gene expression and dynamic DNA demethylation to activate pluripotency gene transcriptio

286 triggered by TET catalysis, ranging from DNA demethylation to chromatin and transcription regulation.

287 ding sequence 2 (CNS2), is activated via DNA demethylation to establish epigenetic memory of Foxp3 ex

288 contributes substantially more than passive demethylation to establishing low methylation levels at

289 ic barrier that can be removed by active DNA demethylation to permit axon regeneration in the adult m

290 tic reprogramming by regionally opposing DNA demethylation to preserve vital parental information to

291 In a low-immunogenic tumor model, DNA demethylation upregulates cryptic transcript expression

292 The ratio of methylation to demethylation varied between 0.3 and 1.5, suggesting tha

293 s have also been proposed to function in DNA demethylation via deamination of either 5-methylcytosine

294 Active DNA demethylation via ten-eleven translocation (TET) family

295 Foxp3 demethylation was associated with tolerance induction, i

296 ted expression of H19 lncRNA due to promoter demethylation was observed in cells isolated from metast

297 at fail to produce siRNA may be targeted for demethylation when the cell cycle arrests.

298 y is required, albeit indirectly, for global demethylation, which mostly occurs at sites devoid of TE

299 Demethylation with azacytidine in cultured sympathetic g

300 trast, we did not observe N-methyl arginyl N-demethylation with purified JMJD6.