ライフサイエンスコーパス: denervation

1 /6J mice and this effect was abolished by CB denervation.

2 ctivation must be tightly balanced following denervation.

3 s and phenol-based hepatic sympathetic nerve denervation.

4 ration of differentiated taste cells despite denervation.

5 occurred in 15 patients with severe baseline denervation.

6 hosphorylation is sustained during long-term denervation.

7 d neuromuscular fragmentation and occasional denervation.

8 he blood-pressure-lowering efficacy of renal denervation.

9 ritical atrial regions responsible for vagal denervation.

10 d molecular analyses revealed no evidence of denervation.

11 hat non-AFN ablation promotes no significant denervation.

12 tral auditory system after profound cochlear denervation.

13 Non-AFN ablation causes no significant vagal denervation.

14 y ganglia, we avoided widespread sympathetic denervation.

15 ssed in regenerating blastemas but lost upon denervation.

16 e of wild-type mice after surgically induced denervation.

17 is sufficient to prevent changes induced by denervation.

18 nt levels of activated caspase-3 but limited denervation.

19 Ns) preceded by neuromuscular junction (NMJ) denervation.

20 in nonballoon denervation but not in balloon denervation.

21 vated muscle and suppressed following muscle denervation.

22 ology and clinical significance of sudomotor denervation.

23 in all walking conditions were evident after denervation.

24 ients who underwent left cardiac sympathetic denervation.

25 easuring changes in DNA synthesis after limb denervation.

26 uron degeneration and prolonged distal nerve denervation.

27 n ECVS=P<0.0001), demonstrating robust vagal denervation.

28 This was also the case following afferent denervation.

29 AFN ablation causes significant vagal denervation.

30 lved nerve and muscular changes secondary to denervation.

31 changes and synaptic gene up-regulation upon denervation.

32 leptin on V(E) and HVR were abolished by CB denervation.

33 of denervation/reinnervation and persistent denervation.

34 muscular junction following ischemia-induced denervation.

35 polar voltages varied widely within areas of denervation (0.8 mV [Q1-Q3, 0.3-1.7 mV] and 4.0 mV [Q1-Q

36 alue of EAT thickness on cardiac sympathetic denervation ((123)I-MIBG early and late heart:mediastinu

37 ) (HVR) in C57BL/6J mice before and after CB denervation; (2) to express LepR(b) in CB of LepR(b) -de

38 , but the muscle mutation caused progressive denervation, acetylcholine receptor (AChR) cluster fragm

39 evaluate the effectiveness of radiofrequency denervation added to a standardized exercise program for

40 he blood pressure-lowering efficacy of renal denervation added to a standardized stepped-care antihyp

41 atrial fibrillation and hypertension, renal denervation added to catheter ablation, compared with ca

42 ortant and significant vagal and sympathetic denervation after 2 years of cardioneuroablation with a

43 n 25 (4%) patients, left cardiac sympathetic denervation alone in 18 (3%) patients, and combination t

44 ive motor neuron loss, gait problems, muscle denervation and atrophy, paralysis, and have diminished

45 terized by motoneuron death, skeletal muscle denervation and atrophy.

46 (NMJs), prolonged inactivity leads to muscle denervation and atrophy.

47 terventional approaches, transcatheter renal denervation and baroreflex activation therapy, are used

48 twork was abrogated by carotid chemoreceptor denervation and by pharmacological blockade of either sy

49 in pain intensity between the radiofrequency denervation and control groups at 3 months was -0.18 (95

50 ximately 50%) but not different in the renal denervation and control groups.

51 master athletes showed attenuated indices of denervation and greater reinnervation capacity.

52 ion of miR-29b attenuates atrophy induced by denervation and immobilization.

53 ventions, including left cardiac sympathetic denervation and implantation of a cardioverter-defibrill

54 NMDAR transmission occurring under dopamine denervation and L-DOPA therapy.

55 observed in disease models, contributing to denervation and motoneuron dysfunction.

56 ction or disease pathology, including muscle denervation and motor neuron loss.

57 To determine the role of denervation and motor unit turnover in the age-related i

58 ion causes a significant reduction in muscle denervation and neuromuscular junction degeneration in h

59 In carriers, both skin denervation and peptidergic sudomotor denervation were e

60 ts, progressive neuromuscular junction (NMJ) denervation and pre-synaptic build-up of mutant GlyRS.

61 with the earliest detectable signs of muscle denervation and preceded physiologically measurable moto

62 scle atrophy relates to the degree of muscle denervation and the capacity of successful reinnervation

63 ve treatment were not different in the renal denervation and the control groups, respectively (P=0.36

64 an arterial pressure in rats with sinoaortic denervation and vagotomy.

65 rvical SCI results in rVRG axon damage, PhMN denervation, and consequent partial-to-complete paralysi

66 us contributing to axon degeneration, muscle denervation, and motor neuron cell death in SMA.

67 Electromyography shows denervation, and patients often report that early sympto

68 ations on electromyography indicating active denervation, and reduced compound muscle action potentia

69 h as flecainide and left cardiac sympathetic denervation are not well validated.

70 defibrillators, and left cardiac sympathetic denervation are part of the current treatment options, b

71 However, the specific role of denervation as a determinant of the severity of muscle a

72 clinical studies have identified sympathetic denervation as a predictor of increased arrhythmia susce

73 known to activate HuR, was induced following denervation as a result of MKK3/6 activation and a decre

74 We expressed global and regional LV denervation as the percentage extent of z score severity

75 e intervention group received radiofrequency denervation as well.

76 wasted, with highly atrophied type 1 fibers, denervation at most synaptic sites, induction of "fetal"

77 loss of motor neurons in the spinal cord or denervation at the neuromuscular junction.

78 otype, resulting in a maladapted response to denervation at the NMJ in ALS.SIGNIFICANCE STATEMENT Und

79 ochondrial H(2)O(2) does not protect against denervation atrophy, suggesting ETC generated H(2)O(2) i

80 Another exception is denervation-atrophy where nuclei are not eliminated.

81 B blockade in rats with stable nigrostriatal denervation attenuated the forelimb akinesia improvement

82 gehog signaling in normal touch domes, while denervation attenuates touch dome-derived tumors.

83 phy) and the degree of striatal dopaminergic denervation based on (11)C-DTBZ PET.

84 ome inhibition can be delayed 3-4 days after denervation but is required throughout skeletal growth t

85 scular ultrasound was observed in nonballoon denervation but not in balloon denervation.

86 Cardioneuroablation, the vagal denervation by radiofrequency ablation of the neuromyoca

87 Renal denervation can reduce cardiac sympathetic activity that

88 lity in the blood pressure response to renal denervation can still be observed and remains a challeng

89 Furthermore, local stimuli, such as denervation, can induce transcriptional responses that a

90 Instead, neonatal denervation causes a permanent longitudinal growth defic

91 Carotid body denervation (CBD) causes hypoventilation and increases t

92 liorating the deleterious effects of chronic denervation (CD) injury on nerve regeneration and result

93 Using a combination of adrenalectomy, denervation, chemogenetics(3,4), cell ablation and knock

94 zed by the International Cardiac Sympathetic Denervation Collaborative Group.

95 nts, or intervertebral disks, radiofrequency denervation combined with a standardized exercise progra

96 owed the superiority of catheter-based renal denervation compared with a sham procedure to safely low

97 inical models we proposed that noradrenergic denervation contributes to the impairment of response in

98 t PSC functions would be altered even before denervation, contributing to NMJ malfunctions.

99 omyocardium interface identification and the denervation control and validation.

100 Cardiac sympathetic denervation (CSD) has been shown to reduce the burden of

101 Carotid sinus nerve denervation (CSD) has recently been shown to relieve hyp

102 ve previously shown that carotid sinus nerve denervation (CSD) reduces arterial blood pressure (ABP)

103 This study aims to verify the vagal denervation degree in the chronic phase after cardioneur

104 mice also exhibited evidence of bone marrow denervation, demonstrating a loss of neurofilament-200 s

105 levels in the fibers of atrophic muscles via denervation-dependent and -independent mechanisms.

106 pear to act, at least in part, by inhibiting denervation-dependent induction of Myog and Gdf5 gene ex

107 Conversely, functional recovery following denervation depends on successful reinnervation.

108 A mouse model of unilateral denervation detected remarkable specificity in alteratio

109 l uptake had no interval change; 3 with mild denervation developed interval decline in lateral and in

110 After a critical period, a state of chronic denervation develops as repair Schwann cells lose their

111 e investigated the slower atrophy induced by denervation (disuse).

112 y processing recover after profound cochlear denervation due to a progressive, compensatory plasticit

113 nd 48 of 101 non-crossover subjects; 6-month denervation follow-up was available for 93 of 101 crosso

114 red immediately or after 4 months of chronic denervation, followed by administration of Herceptin or

115 difference between the groups favoured renal denervation for 3-month change in both office and 24-h b

116 eded evidence to guide clinical use of renal denervation for hypertension treatment and other potenti

117 The DENERHTN trial (Renal Denervation for Hypertension) confirmed the blood pressu

118 Cortical cholinergic denervation frequency increased monotonically with incre

119 n the 23 paired PET scans, worsening cardiac denervation (global diff-SEP > 9) occurred in 14 of 23 (

120 and from 150 mm Hg to 135 mm Hg in the renal denervation group (between-group difference, -13 mm Hg;

121 olation-only group and 7 (4.5%) of the renal denervation group.

122 Catheter-based renal denervation has significantly reduced blood pressure in

123 s that control skeletal muscle atrophy after denervation have been established, the transcriptome in

124 dergoing pulmonary vein isolation plus renal denervation (hazard ratio, 0.57; 95% CI, 0.38 to 0.85; P

125 Direct mechanical denervation impairs heart regeneration in neonatal mice,

126 was used in 24% and left cardiac sympathetic denervation in 8%.

127 fective at preventing neuromuscular junction denervation in a mutant SOD1(G93A) mouse model of amyotr

128 ETTING, AND PARTICIPANTS: The Evaluate Renal Denervation in Addition to Catheter Ablation to Eliminat

129 was examined in vivo in a model of chemical denervation in adult rats.

130 Bone growth and remodeling is inhibited by denervation in adults and children, resulting in alterat

131 of vascular injury was observed after renal denervation in all systems; however, different patterns

132 nter to expectation, we found no evidence of denervation in either model, but junctions in both model

133 ented the pathological evidence of sudomotor denervation in FAP.

134 reased EAT thickness and cardiac sympathetic denervation in heart failure.

135 ect regional patterns of cardiac sympathetic denervation in idiopathic Parkinson disease (IPD) using

136 We used unilateral whisker denervation in male and female mice to detect circuitry

137 fective cells, but injection of Pgk1 rescued denervation in muscle-specific NogoA-overexpression of z

138 to minimise loss of muscle fibres following denervation in older age, which may be more successful i

139 Following neonatal forelimb denervation in P5 mice, we first outlined the minimum pe

140 hogenesis and time course of parasympathetic denervation in Parkinson's disease is limited and would

141 istically significant benefit favoring renal denervation in patients with RH.

142 (Renal Denervation in Patients With Uncontrolled Hypertension [

143 estigated RTM in the SYMPLICITY HTN-3 (Renal Denervation in Patients With Uncontrolled Hypertension)

144 rst specific quantification of noradrenergic denervation in PD patients in vivo.

145 imed to determine the presence and extent of denervation in pre-frail/frail elderly (FE, 77.9 +/- 6.2

146 l proSpective registrY for syMPathetic renaL denervatIon in seleCted IndicatIons Through 3 Years Regi

147 l proSpective registrY for syMPathetic renaL denervatIon in seleCted IndicatIons Through 3 Years Regi

148 of glial axonal debris phagocytosis, on NMJ denervation in SOD1 mice.

149 was designed to assess the efficacy of renal denervation in the absence of antihypertensive medicatio

150 nological changes after radiofrequency-renal denervation in the swine model.

151 s DAergic neuron demise and striatal DAergic denervation in vivo against PD-causing toxins in a Nurr1

152 rimental baroreflex dysfunction (sino-aortic denervation) in rats and mice.

153 Previous work showed that muscle denervation increases expression of AChR mRNAs due to tr

154 We show that denervation increases expression of the RNA-binding prot

155 We show that denervation increases muscle cPLA(2) protein content, ac

156 that pathological muscle conditions such as denervation induce alterations in exosomal miR profile w

157 s of Duchenne's muscular dystrophy (mdx) and denervation-induce atrophy, but its role and mechanisms

158 rom controls in terms of size, resistance to denervation-induced atrophy, and force.

159 dult muscle induces hypertrophy and prevents denervation-induced atrophy.

160 ddition, antiprogestins RU 38486 blunted the denervation-induced decrease in mRNA levels of TGF-beta

161 d inflammatory signaling during carotid body denervation-induced hypercapnia, we hypothesized chronic

162 tosolic redox homeostasis in the presence of denervation-induced increase in mitochondrial peroxide g

163 nant human TGF-beta1 (rhTGF-beta1) prevented denervation-induced reduction of BMD further supporting

164 To explore the relation between denervation-induced reduction of bone formation and TGF-

165 f BMD further supporting our hypothesis that denervation-induced reduction of bone formation is a res

166 These results suggest that denervation-induced reduction of bone formation may be r

167 ed by sustained mTORC1 activation, abrogates denervation-induced synaptic remodeling and causes neuro

168 Our previous studies demonstrated that denervation induces muscle mitochondrial hydroperoxide p

169 nd desmin filaments were intact at 7 d after denervation, inducing the dissociation of desmin filamen

170 Splenic denervation interrupts the anti-inflammatory neural arc,

171 Radiofrequency denervation is a commonly used treatment for chronic low

172 Renal denervation is a new treatment considered for several po

173 Autonomic denervation is an alternative approach for patients with

174 Renal denervation is an endovascular procedure, whereby the ab

175 Conversely, dopaminergic denervation is associated with selective D-serine reduct

176 To determine whether denervation is caused directly by the virus or indirectl

177 bers, precedes wasting of mutant soleus; (3) denervation is likely to drive this wasting, and (4) the

178 Renal sympathetic denervation is the most extensively investigated device-

179 We proposed left cardiac sympathetic denervation (LCSD) as useful additional therapy, but evi

180 Videoscopic left cardiac sympathetic denervation (LCSD) is an effective antifibrillatory, min

181 We conclude that, in rats, CB denervation may not produce CCR plasticity.

182 the transient hypoventilation elicited by CB denervation means that these afferents are active under

183 enal artery wall injury with relation to the denervation method is unknown.

184 Sympathetic tone is increased in sensory denervation models, and propranolol, a beta2-adrenergic

185 shows decreased survival, paralysis, muscle denervation, motor neuron loss, anxiety-like behavior, a

186 sion, we measured mRNA levels of TGF-beta in denervation mouse bone and found decreased mRNA levels o

187 Moreover, both lines displayed denervation muscle atrophy and age-dependent loss of mot

188 148) or pulmonary vein isolation plus renal denervation (n = 154).

189 ients were randomly assigned to either renal denervation (n=166) or a sham procedure (n=165).

190 80 patients were randomly assigned to renal denervation (n=38) or sham control (n=42) and followed u

191 Because NMJ denervation occurs early in the process and that perisyn

192 Sensory denervation of a genetically engineered mouse model of P

193 decline of neurological impairment, delayed denervation of hindlimb muscles, and prolonged survival

194 efore, represent a marker of parasympathetic denervation of internal organs, but further validation s

195 After denervation of mouse tibialis anterior muscles, phosphor

196 ons collapses, however, at the time that the denervation of muscle fibers begins at about P50, result

197 y women is the robustness of the response to denervation of myofibers.

198 y women is the robustness of the response to denervation of myofibres.

199 dult onset progressive motor neuron loss and denervation of neuromuscular junctions.

200 urgical removal of the periosteum, capsaicin denervation of sensory nerves or knockdown in vivo of th

201 trophic lateral sclerosis (ALS) results from denervation of skeletal muscle as a consequence of motor

202 Denervation of skeletal muscle has been previously used

203 in both cancer and cachexia, suggesting that denervation of skeletal muscle is not a major driver of

204 Denervation of skeletal muscles induces severe muscle at

205 The functional denervation of spinal interneurons within the mature SDH

206 Synaptic pathology and denervation of target muscle fibers has been reported pr

207 ed the effectiveness of surgical sympathetic denervation of the common hepatic artery (CHADN) in impr

208 e of fully regenerating amputated limbs, but denervation of the limb inhibits the formation of the po

209 Moreover, prior denervation of the liver abolished the improved counterr

210 Denervation of the neuromuscular junction (NMJ) precedes

211 ord as well as a significant decrease in the denervation of the neuromuscular junction of the tibiali

212 uced by vasoconstriction, and to demonstrate denervation of the pulmonary artery at a histological le

213 Denervation of the skin impairs cutaneous healing, prese

214 's disease leads to progressive dopaminergic denervation of the striatum, impairing the function of c

215 y inhibition accelerated early neuromuscular denervation of the tibialis anterior muscle and the onse

216 he effect of radiofrequency pulmonary artery denervation on acute pulmonary hypertension induced by v

217 ur study was to evaluate the effect of renal denervation on blood pressure in the absence of antihype

218 l exercise training regimen in humans and to denervation or clenbuterol treatment in rodents.

219 ced myofibril disassembly and degradation on denervation or fasting.

220 ctive thermogenic state, whereas sympathetic denervation or glucocorticoid administration promotes mo

221 ated deficits in forelimb akinesia, striatal denervation or loss of SNpc neuron, nor did STN DBS elev

222 tients to reoperation with either additional denervation or pallidal stimulation.

223 Tumour growth was inhibited by sensory denervation or pharmacological blockade of adrenergic re

224 iography and were randomly assigned to renal denervation or sham control.

225 Eligible subjects were randomized 2:1 to denervation or sham procedure.

226 were randomly assigned 1:1 to either a renal denervation or sham procedure.

227 ration of rAAV:Fst to muscles at the time of denervation or tenotomy did not prevent subsequent muscl

228 hypoxia (10 and 12% FiO2), after sino-aortic denervation, or during isoflurane anesthesia.

229 rs a new approach to objective assessment of denervation over short timescales in MND and enables inv

230 Pulmonary artery denervation (PADN) procedure has not been applied to pat

231 dity resulting from left cardiac sympathetic denervation, patients with LQTS and CPVT have high level

232 extent < 30%), and 22 had moderate to severe denervation (percentage extent > 30%, z score </= 2.5 SD

233 ents had normal (11)C-HED PET, 5 showed mild denervation (percentage extent < 30%), and 22 had modera

234 Regardless of adherence to treatment, renal denervation plus standardized stepped-care antihypertens

235 pine 10 mg/d were randomly assigned to renal denervation plus standardized stepped-care antihypertens

236 (2) Percentage of positive denervation potential was higher in tibialis anterior th

237 , SI) and semi-quantitative scoring scale of denervation potential.

238 580 treatment protected skeletal muscle from denervation prior to its effects on microglial cells.

239 The lack of a formal sham-control renal denervation procedure should be considered in interpreti

240 yephedrine ((11)C-HED) PET and determine the denervation rate over 2 y.

241 Renal denervation (RDN) can reduce renal and whole-body sympat

242 at 2 months by endovascular ultrasound renal denervation (RDN) compared with a sham procedure among p

243 applying catheter-based radiofrequency renal denervation (RDN) demonstrated a favorable safety profil

244 The therapeutic potential of renal denervation (RDN) for arrhythmias has not been fully exp

245 her insulin sensitivity improved after renal denervation (RDN) for resistant hypertension.

246 nd ultrasound endovascular renal sympathetic denervation (RDN) have proven clinical efficacy for the

247 Renal denervation (RDN) is a catheter-based ablation procedure

248 Catheter-based renal denervation (RDN) is currently under development for the

249 Renal denervation (RDN) is under investigation for treatment o

250 sized that inhibiting the SNS by using renal denervation (RDN) will improve insulin sensitivity (SI)

251 carotid baroreflex and catheter-based renal denervation (RDN).

252 ic nuclei, indicative of recurring cycles of denervation/reinnervation and persistent denervation.

253 Muscle biopsies showed chronic denervation/reinnervation changes, whereas biochemical a

254 n of ephrin-A3 on fast myofibers followed by denervation/reinnervation promotes their respecification

255 and Wnt signaling might be playing in muscle denervation/reinnervation.

256 ere obtained from all three groups to assess denervation-related morphological and transcriptional ma

257 ontrolling the integrated muscle response to denervation remain largely unknown.

258 Studies of renal denervation report disparate results.

259 il breakdown normally observed at 14 d after denervation required not only dissociation of desmin fil

260 Denervation resulted in a marked increase in miR-206 and

261 Trigeminal denervation resulted in epithelial defects with or witho

262 axons in the sciatic nerve suggest that this denervation results from disturbances of axonal transpor

263 ed the effects of radiofrequency renal nerve denervation (RF-RDN) on the pathobiology of HF and the i

264 relative effectiveness of renal sympathetic denervation (RSD) in patients with hypertension.

265 endently rated fascicular lesions and muscle denervation signs on a five-point scale and made an imag

266 Muscle denervation signs were more prominent in ALS than in MMN

267 ry nerve grew progressively weaker following denervation, sound-evoked activity in the cortex-and, to

268 Previous randomised renal denervation studies did not show consistent efficacy in

269 Three recent renal denervation studies in both drug-naive and drug-treated

270 mation of sources and magnitude of biases in denervation studies.

271 ctional impact will require consideration in denervation studies.

272 month follow-up was available for 319 of 361 denervation subjects and 48 of 101 non-crossover subject

273 In denervation subjects, the 12-month office systolic BP (S

274 It has been suggested that cochlear denervation ("synaptopathy") is an early contributor to

275 ied in balloon-based and in nonballoon-based denervation systems.

276 h correspondingly fewer vesicles and partial denervation that eliminates some release sites also cont

277 B is part of a molecular signature of muscle denervation that may reflect disease progression in ALS.

278 n that contractures uniquely follow neonatal denervation, the current study tests the hypothesis that

279 In balloon denervation, the presence of dissections by OCT was asso

280 rdioneuroablation provides therapeutic vagal denervation through endocardial radiofrequency ablation

281 Rationale: Targeted lung denervation (TLD) is a bronchoscopic radiofrequency abla

282 Deletion of Tff2 recapitulates splenic denervation to promote carcinogenesis.

283 ine dietary manipulation and pharmacological denervation to target pancreatic cancer.

284 ngs do not support the use of radiofrequency denervation to treat chronic low back pain from these so

285 inical research related to renal sympathetic denervation to treat HF.

286 tion of all pulmonary vein potentials; renal denervation using an irrigated-tip ablation catheter del

287 Bilateral renal denervation using phenol application to the renal arteri

288 als were assigned to either pulmonary artery denervation, using a prototype radiofrequency catheter a

289 ECVS was fundamental to stepwise vagal denervation validation during cardioneuroablation.

290 th Uncontrolled Hypertension) trial of renal denervation versus a sham procedure.

291 Early significant caudate dopaminergic denervation was found in half of the cases in the PPMI s

292 in both muscles until preonset (P380), while denervation was frequent in the mutant mouse.

293 Vagal denervation was performed to assess its effect on liver

294 ression indicators of neuromuscular junction denervation were diminished using a low dose of a "rapal

295 h skin denervation and peptidergic sudomotor denervation were evident: (1) IENF density was gradually

296 CB removal or denervation were previously shown to reduce hypertension

297 ly women exhibited marked features of muscle denervation, whereas world class octogenarian female mas

298 Unilateral renal denervation, which partly attenuated blood pressure, onl

299 50 renal arteries) underwent bilateral renal denervation with 5 different systems, 3 of which balloon

300 isted thoracoscopic left cardiac sympathetic denervation, with a median follow-up of 29 months (range