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2 tolerated and was associated with a reduced dentate and caudate nucleus iron content compared to pla
4 rsal on MRI (100%), with cerebral atrophy or dentate and pontine T2 hyperintensities observed in 28%.
5 (in inverse seconds [sec(-1)]) values of the dentate (case participants: 0.06 ppm +/- 0.04 and 23.87
7 peptide cholecystokinin (CCK), released from dentate CCK interneurons, in regulating neurogenic niche
8 croelectrode array (MEA) was used to monitor dentate (DG), CA3, and CA1 hippocampal extracellular glu
9 reover, the TLR4-dependent early increase in dentate excitability is causally associated with epilept
10 complementary neural codes: a rate code for dentate fast-spiking interneurons, a burstiness code for
11 Mean susceptibility and R2* values of the dentate (first MRI: 0.06 ppm +/- 0.05 and 25.78 sec(-1)
13 romote seizures.SIGNIFICANCE STATEMENT Adult dentate granule cell (DGC) neurogenesis is altered in ro
14 tify that TLR4 signaling in neurons augments dentate granule cell calcium-permeable alpha-amino-3-hyd
15 outing of hippocampal mossy fiber axons onto dentate granule cell dendrites creates a recurrent excit
17 us subregion of the hippocampus give rise to dentate granule cells (DGCs) and astrocytes throughout l
20 knockout mice in which the vast majority of dentate granule cells (DGCs) fail to develop - including
22 nce of striking morphological alterations in dentate granule cells (DGCs) of FTD patients and in a mo
24 Cs) in the dentate gyrus receive inputs from dentate granule cells (GCs) and project back to GCs loca
25 ns between perforant path (PP) afferents and dentate granule cells (GCs), a circuit involved in memor
27 an electrophysiology-based classification of dentate granule cells and mossy cells in mice that we va
28 ppocampal adult neurogenesis, and adult-born dentate granule cells contribute to the pathologic retro
29 of varied [GABA] onto nucleated patches from dentate granule cells demonstrated a deactivation rate o
30 at the dynamic dispersion of newly generated dentate granule cells in the neurogenic zone is a requir
31 ssy cells are significantly more active than dentate granule cells in vivo, exhibit spatial tuning du
32 ime to our knowledge, that the population of dentate granule cells is disconnected from other regions
33 ss of circuit integration of newly-generated dentate granule cells of the hippocampus has been presum
35 manently marked activated mature hippocampal dentate granule cells using conditional Fos-TRAP mice.
40 to a novel stimulus, SINEs are activated in dentate granule neurons in a time course that is similar
42 We find that inhibition of Tiam1 function in dentate granule neurons reduces synaptic AMPA receptor f
43 the regulation of glutamatergic synapses in dentate granule neurons using a combination of molecular
46 ogram of glutamatergic synapse regulation in dentate granule neurons.SIGNIFICANCE STATEMENT Several l
48 strongest effects on the CA3 region and the dentate gyrus (CA3-DG) of the hippocampus, alongside ass
51 r perturbation expressed only in hippocampal dentate gyrus (DG) and assessed its association with hip
52 r representations for unexpected items, with dentate gyrus (DG) and CA3 being more sensitive to expec
57 heta-band short range communications between dentate gyrus (DG) and the Ammon's horn (CA1) within the
59 on.SIGNIFICANCE STATEMENT Mossy cells in the dentate gyrus (DG) are an integral component of the DG/p
61 g advantage of the fact that the hippocampal dentate gyrus (DG) gives rise to newborn DGCs throughout
65 oung adult-born granule cells (abGCs) in the dentate gyrus (DG) have a profound impact on cognition a
66 ferent regions and layers of the hippocampus dentate gyrus (DG) in an electric stimulation rodent mod
69 emory impairments.SIGNIFICANCE STATEMENT The dentate gyrus (DG) is important for learning, memory, pa
70 on from the supramammillary nucleus (SuM) to dentate gyrus (DG) is needed for contextual memory, soci
75 imuli.SIGNIFICANCE STATEMENT The hippocampal dentate gyrus (DG) of rodents generates newborn dentate
76 ells (DGCs) are generated in the hippocampal dentate gyrus (DG) of rodents through a process called a
77 roblasts and neuronal differentiation in the dentate gyrus (DG) of the hippocampus and significantly
80 nd DISC1 influence adult neurogenesis in the dentate gyrus (DG) of the hippocampus, we hypothesized t
81 sis in the subventricular zone (SVZ) and the dentate gyrus (DG) of the hippocampus, whereas the impla
86 brain varied between 6.6 +/- 0.7 muM in the dentate gyrus (DG) region of the hippocampus and 22.1 +/
92 attern separation processes supported by the dentate gyrus (DG) to prevent interference from overlapp
95 rant path (PP) to the molecular layer of the dentate gyrus (DG) where information is filtered and con
97 ocused on the hippocampus and especially the dentate gyrus (DG), a vulnerable brain region and one of
98 s and impaired GABAergic transmission in the dentate gyrus (DG), accompanied by schizophrenia-like be
99 (MCs), a major cell type in the hilus of the dentate gyrus (DG), are unique in providing extensive lo
100 subfields cornu ammonis 2/3 (CA2/3) and CA4/dentate gyrus (DG), as well as impaired hippocampal micr
101 ch of the three major hippocampal subfields, dentate gyrus (DG), CA3, and CA1, has a unique function
102 of neural stem cells (NSCs) in the postnatal dentate gyrus (DG), drastically increased perinatal apop
103 ltered inputs from the entorhinal cortex and dentate gyrus (DG), the proximal CA3 region of aged rats
104 nts of adult neurogenesis in the hippocampal dentate gyrus (DG), while the effects of antidepressants
105 ncement, but whether, and to what extent can dentate gyrus (DG)-resident neural stem cells drive rege
109 ically profile the granule cell layer of the dentate gyrus (DG-GCL) in human hippocampus and contrast
111 in the CA1 and CA3 fields, the hilus of the dentate gyrus (with sparing of granule cells), and the e
113 emonstrate that dopamine D1 receptors in the dentate gyrus act as a pivotal mediator of antidepressan
116 heories of hippocampal function suggest that dentate gyrus and CA(2,3) (DG/CA(2,3)) are biased to dif
119 We changed the conductances of simulated dentate gyrus and CA3 hippocampal neurons according to o
120 ions in the synaptic connections between the dentate gyrus and CA3, which are thought to be critical
121 se in neuronal cytoplasmic inclusions in the dentate gyrus and cornu ammonis regions 1 and 2 of patie
122 4 (TLR4) on excitability of the hippocampal dentate gyrus and epileptogenesis after brain injury.
123 Adult neurogenesis persists in the rodent dentate gyrus and is stimulated by chronic treatment wit
124 eurogenesis in the granule cell layer of the dentate gyrus and rescues hippocampal memory defects in
125 GABAergic LRNs preferentially innervate the dentate gyrus and the CA3 area of the hippocampus, regio
129 contextual fear memory engrams in the mouse dentate gyrus contain functionally distinct neuronal ens
132 del of temporal lobe epilepsy, the epileptic dentate gyrus excessively recruits granule cells in beha
134 (2020) report that human tau accumulation in dentate gyrus GABAergic interneurons disrupts AHN and st
136 bors and dendritic spines in newly generated dentate gyrus granule cell neurons of the hippocampus af
138 we characterized threshold K(+) currents in dentate gyrus granule cells (DGGCs) and CA1 pyramidal ce
139 in-positive (DCX(+)) ABGCs as well as DCX(-) dentate gyrus granule cells 2 weeks after a stroke or sh
140 d a hyperexcitability phenotype displayed in dentate gyrus granule neurons derived from patients with
141 Having previously studied the phenotype of dentate gyrus granule neurons, we turned our attention t
143 ignificantly associated with smaller CA3 and dentate gyrus hippocampal subfield volumes but not with
144 pus, a widely accepted model posits that the dentate gyrus improves learning and memory by enhancing
145 evidence of disrupted microstructure of the dentate gyrus in children with OSAS that may help explai
146 We demonstrate lower mean diffusivity of the dentate gyrus in children with OSAS, which correlates wi
148 we simultaneously recorded from the CA1 and dentate gyrus in pilocarpine-treated epileptic mice with
149 al and incorporation of neurons in the adult dentate gyrus increases after chronic stress and suggest
150 gest that stimulation of D1 receptors in the dentate gyrus is a potential adjunctive approach to impr
151 hypothesized that adult neurogenesis in the dentate gyrus is an ongoing process that maintains norma
153 ing to test the hypothesis that aging of the dentate gyrus is linked to impaired beacon discriminatio
155 In addition, ablation of Shh in the adult dentate gyrus led to increased neural precursor cell pro
157 s of pathway-tracing experiments showing the dentate gyrus mossy fiber projection, and its relationsh
158 20) reveal that post-tetanic potentiation at dentate gyrus mossy fiber synapses is induced by natural
159 irm that deficits are specifically linked to dentate gyrus neurogenesis since cyclin D2(-/-) mice als
161 ls of the innate immune system reside in the dentate gyrus neurogenic niche of aged brains in humans
165 ortin immunohistochemistry) cells within the dentate gyrus of adult Egyptian fruit bats from three di
168 e of a dramatic shift in excitability in the dentate gyrus of Pafah1b1(+/-) mice that may contribute
169 on of Ephexin5 expression using shRNA in the dentate gyrus of presymptomatic adolescent hAPP mice was
172 umber of newborn neurons incorporated in the dentate gyrus of the hippocampus during the 10-week post
174 anced deposition of perineuronal nets in the dentate gyrus of the hippocampus of AS mice in the absen
176 ddressed whether mossy fiber inputs from the dentate gyrus onto CA3 principal cells are affected in a
177 albumin-expressing interneurons (PVs) in the dentate gyrus provide activity-dependent regulation of a
178 ion channel agonist, we studied the role of dentate gyrus PV cells in regulating anxiety-like behavi
180 e behavior, whereas upregulation of Kv3.1 in dentate gyrus PV cells or acute activation of Kv3.1 usin
182 enuated capacity of high-frequency firing in dentate gyrus PV cells, and altered short-term plasticit
184 Excitatory hilar mossy cells (MCs) in the dentate gyrus receive inputs from dentate granule cells
185 rtin-labeled maturing newborn neurons in the dentate gyrus subgranular zone, and a single-Reelin infu
186 al glia-like neural stem cells (RGLs) in the dentate gyrus subregion of the hippocampus give rise to
187 development of glutamatergic perforant path-dentate gyrus synapses, but not in commonly studied in S
188 d progressive microstructural changes in the dentate gyrus translate to the severity of hippocampal s
190 nockout granule neurons integrating into the dentate gyrus using a variety of methods to examine thei
191 between parental education level and CA3 and dentate gyrus volumes; lower parental education level wa
193 ocampal subfield CA3 (but less pronounced in dentate gyrus) correlated with this form of mnemonic pat
194 piriform cortex, 0.24 ug . g(-1) +/- 0.04 in dentate gyrus, 0.17 ug . g(-1) +/- 0.04 in hippocampus)
195 rties of netfeedback inhibition in the mouse dentate gyrus, a region critically involved in pattern s
198 prominently expressed on the neurons of the dentate gyrus, but its role in mediating behavioral resp
199 00 distinct neuron type pairs throughout the dentate gyrus, CA3, CA2, CA1, subiculum, and entorhinal
200 granule cells, the projection neurons of the dentate gyrus, can exhibit both pattern separation and i
201 nt developed more neuronal inclusions in the dentate gyrus, cornu ammonis regions 1, 2 and 4, and the
202 more neuronal cytoplasmic inclusions in the dentate gyrus, cornu ammonis regions 1-4 and entorhinal
204 cognitive functions and neurogenesis (e.g., dentate gyrus, hypothalamus, olfactory areas, cerebellum
207 duced with decreased size of the hippocampal dentate gyrus, partial agenesis of the corpus callosum,
209 of the hippocampal formation (cornu Ammonis, dentate gyrus, subicular complex, and entorhinal cortex)
210 binding in the hippocampus (CA1, CA2/3, CA4, dentate gyrus, subiculum) and presubiculum layers (PSB1,
212 ampus, neurogenesis was nearly absent in the dentate gyrus, which was due to inhibited proliferation
213 ce of NLGN1 decreased neuronal counts in the dentate gyrus, which was not the case in wild-type anima
214 s fibres in the medial entorhinal cortex and dentate gyrus, with no frank noradrenergic cell body los
215 tformin enhanced the recovery of NPCs in the dentate gyrus, with sex-dependent effects on neurogenesi
217 etical models and the known functions of the dentate gyrus-CA3 circuit, acute or chronic manipulation
221 (56)Fe irradiation improved performance on a dentate gyrus-reliant pattern separation task; irradiate
245 resentations for overlapping memories in the dentate gyrus/CA(2,3) and subiculum subfields of the hip
246 projecting pyramidal cells, but not putative dentate gyrus/CA3-projecting stellate cells, represented
247 Mossy cells are excitatory neurons in the dentate hilus that regulate dentate gyrus activity and f
249 e rigidity, one of the tpy units of the tris-dentate ligand was preblocked by stable <tpy-Ru(2+)-tpy>
252 mma2, and delta were highly expressed in the dentate molecular layer, whereas alpha1, alpha2, alpha3,
255 g in vivo shortly after brain injury reduced dentate network excitability and seizure susceptibility.
256 opx(+) embryonic, early postnatal, and adult dentate neural progenitors further reveal common molecul
257 we show that Hopx(+) precursors in the mouse dentate neuroepithelium at embryonic day 11.5 give rise
258 We hypothesized that the main function of dentate neurogenesis is long-term memory formation becau
260 by magnetic resonance (MR) imaging, reduced dentate neurogenesis moderately correlated with deficits
261 enitor population exclusively contributes to dentate neurogenesis throughout development and adulthoo
263 avioral endpoints thought to be dependent on dentate neurogenesis, including memory acquisition, shor
264 d that Bax deletion in developing and mature dentate neurons increased EPSCs and prevented neurogenes
265 magnetic resonance (MR) imaging, cerebellar dentate nuclei (DNs) functional connectivity abnormaliti
266 eglumine on the signal intensity (SI) of the dentate nucleus (DN) of the pediatric brain on nonenhanc
267 (GBCAs) on the signal intensity (SI) of the dentate nucleus (DN) on unenhanced T1-weighted magnetic
268 d T1 signal intensities were measured in the dentate nucleus (DN), globus pallidus (GP), crus anterio
269 age, 49 years; age range, 25-73 years), the dentate nucleus (DN)-to-middle cerebral peduncle (MCP) S
270 timulating electrodes targeted to the dorsal dentate nucleus and tested a spectrum of frequencies ran
271 easured in regions of interest placed in the dentate nucleus and the pons, and we calculated the dent
273 decay times of the GABAergic currents to the dentate nucleus can facilitate sustained oscillatory act
275 oning task, cerebellar output neurons in the dentate nucleus exhibit preparatory activity similar to
277 to determine whether signal intensity in the dentate nucleus is increased in unenhanced T1-weighted i
278 hyperintensity of the globus pallidus and/or dentate nucleus on unenhanced T1-weighted magnetic reson
279 ation of alpha(2/3)-receptor subunits in the dentate nucleus, and correspondingly, we studied the evo
280 , ventral intermediate thalamic nucleus, and dentate nucleus, and observed abnormal functional connec
282 rior cerebellar peduncle and the ipsilateral dentate nucleus, which correspond to the ipsilateral por
284 umine administrations and an increase in the dentate nucleus-to-middle cerebral peduncle signal inten
285 sity ratios (globus pallidus-to-thalamus and dentate nucleus-to-pons ratios), and T1 and T2 relaxatio
286 nucleus and the pons, and we calculated the dentate nucleus-to-pons signal intensity ratios and the
292 Hopx(+) neural progenitors in the primitive dentate region, and they, in turn, generate granule neur
297 ypes of LFP events in the DG: high-amplitude dentate spikes (DSs), and a novel event type whose curre
299 etae) and two sets of sclerites (spinose and dentate) suggest that in a pre-annelid an earlier and mo