ライフサイエンスコーパス: depress

1 the high-copper-mobility superionic phase is depressed.

2 als in other NAc subregions are persistently depressed.

3 he input to the reward-related structures is depressed.

4 iring rate information before the synapse is depressed.

5 alized HCN activity, but SK current remained depressed.

6 d patients were significantly more frail and depressed.

7 ory were collected from 204 individuals (105 depressed, 99 healthy).

8 vesicle development and had a significantly depressed activation-induced zinc release compared to WT

9 inhibitor of metalloproteinase-1 and -2; and depressed active and total MMP-9.

10 e pronounced, with raised activity in NI and depressed activity in NP cells (p < 0.05).

11 ychotherapy are effective, only about 40% of depressed adolescents receive treatments due to lack of

12 In depressed adults, abnormalities in the dynamic functioni

13 h DeltaCES-D(total) were replicated for the "depressed affect" domain.

14 our distinctive domains: somatic complaints, depressed affect, positive affect and interpersonal prob

15 es with bacterial outliers had significantly depressed alpha-diversity (median, 0.61; interquartile r

16 ophic plankton community exceeds the supply, depressing ambient concentrations.

17 periods of postsynaptic bursting selectively depressed AMPA receptor (R) synaptic transmission, or si

18 ow-risk healthy, high-risk healthy, remitted depressed and currently depressed children performed in

19 nectivity to reveal subgroups present across depressed and healthy individuals during positive proces

20 would be overlooked in group comparisons of depressed and healthy participants, and tracks with clin

21 ction in depression; ii) the effect of MT on depressed and non-depressed individuals; and iii) neurob

22 , predominantly lipids, was compared between depressed and nondepressed persons.

23 tamine exerts rapid antidepressant action in depressed and treatment-resistant depressed patients wit

24 The primary (1 degrees Mn) type depresses and has a large quantal content (Qc) and a hig

25 rian refugees; three-quarters were 'probably depressed' and would warrant psychiatric assessment.

26 Search terms included depress* AND mindful* OR meditat* AND adolescen* OR stud

27 orphology (P < .007), ulceration (P = .026), depressed areas (P < .001), or nodular mixed type (P < .

28 ecovery enabled wave reentry into previously depressed areas at precisely ictogenic levels of synapti

29 than in service users who had been similarly depressed at baseline (adjusted odds ratio 7.38, 1.73-31

30 Of those, 694 who were not clinically depressed at baseline underwent follow-ups at 6, 12, and

31 Among 354 patients, 68 were depressed at baseline.

32 e fact that locomotory muscle power is often depressed at cold temperatures, these sharks remain capa

33 excitation of BA interneurons (INs) that was depressed at higher frequencies.

34 Importantly, because insulin acts to depress autophagic flux, these derangements in nutrient

35 t, 3 groups were formed: non-depressed (ND), depressed before but not after MT (responsive, D(+)) and

36 apses, whereas more prolonged (24 hr) firing depressed both AMPAR and NMDAR EPSCs and eliminated spin

37 fore but not after MT (responsive, D(+)) and depressed both before and after MT (unresponsive, D(-)).

38 munomodulation in susceptible regions of the depressed brain raised the possibility of altered cellul

39 cted exosome marker CD81, were significantly depressed by a mean of 45% in acute mTBI ( P < 0.0001),

40 r and plasminogen activator inhibitor-1, was depressed by exposure to high glucose, with the reductio

41 Numbers of predators were significantly depressed by synthetic insecticide but higher in other t

42 her action potential propagation failure nor depressed Ca(2+) influx explained loss of evoked synapti

43 Hypercapnia, a surrogate state of depressed CA, leads to marked changes in dynamic CA, tha

44 th permanent myocardial ischemia, leading to depressed cardiac function long term.

45 und debridement, increased infarct size, and depressed cardiac function, newly implicating MerTK in c

46 We found 10 eligible studies (N = 1754 depressed cases and N = 1145 healthy controls).

47 r, functional-group Lewis basicity typically depresses catalytic activity and co-monomer incorporatio

48 nthesis, decreased amino acid metabolism and depressed cell growth were related to RS consumption.

49 at overexpression of PARP10 is sufficient to depress cellular NAD and that the activities of the tran

50 ude and decay rate, lower SR Ca(2+) load and depressed cellular contractility) and SERCA2a downregula

51 , remitted depressed (n = 401) and currently depressed children (n = 102).

52 ral pictures in young (4.0-6.9 years of age) depressed children before and after randomization to eit

53 ral pictures in young (4.0-6.9 years of age) depressed children before and after randomization to eit

54 sk healthy, remitted depressed and currently depressed children performed in various cognitive domain

55 t some loci, but there was a tendency toward depressed CO rates at loci where large structural differ

56 ted with SMIC included Kudo pit pattern V, a depressed component (0-IIc), rectosigmoid location, 0-Is

57 Bilateral kainic acid (KA) infusions depressed compound AN responses by 40-70% without impact

58 nels were used selectively to potentiate and depress conductance.

59 asing thin-filament stiffness and ultimately depressing contractile force and relaxation rate.

60 ms (indicating >=15 on the PHQ-9) and 56 non-depressed controls (indicating <=4) rated the emotional

61 nt depressive symptoms would differ from non-depressed controls in their interpretation of internet m

62 suicide attempts, 25 with ideation only, 25 depressed controls with no ideation, and 31 nonpsychiatr

63 Importantly, elevated CXCR7 and depressed CXCL12 expression levels were prominent featur

64 depressed days 2-4), transferrin saturation (depressed days 2-4), and retinol (depressed days 3, 4, a

65 , hepcidin (elevated days 2, 3), serum iron (depressed days 2-4), transferrin saturation (depressed d

66 aturation (depressed days 2-4), and retinol (depressed days 3, 4, and 7).

67 ells transmit rapid excitatory currents that depress deeply during repetitive activity, driving phasi

68 l growth, suggest that drier conditions will depress densities of fungal consumers, causing declines

69 ing the GDS with a cut-off score of 4/5 (not depressed/depressed).

70 Nifedipine had a depressing effect.

71 peptide contents similarly demonstrated the depressing effects of melittin on membrane bending modul

72 t LV wall thinning, chamber enlargement, and depressed ejection fraction (32.6% vs 61.8%, p < 0.0001)

73 anes from 1500 to 1670 CE, but frequency was depressed elsewhere in the Atlantic Ocean.

74 s early as 5 DIV, reducing SCO amplitude and depressing ESA and burst frequencies by 60-70%.

75 -frequency stimulation (HFS) of BLA and mPFC depressed evoked spike probability in the mPFC and BLA,

76 Thus, whereas CB1 receptors (CB1R) uniformly depress excitatory pathways regardless of MSNs identity,

77 Astrocytes depressed excitatory synapses from basolateral amygdala

78 a(2+), stimulates ATP/adenosine release, and depresses excitatory synaptic transmission through activ

79 nucleus to edge TRN cells evoke slower, less depressing excitatory currents that drive more persisten

80 rexpression of neutrophil protease genes and depressed expression of immunological synapse genes.

81 downregulated in prefrontal cortex (PFC) of depressed females but not males.

82 sed males, and 1199 female controls and 1689 depressed females to obtain independent unbiased brain-b

83 Bath applied Delta(9)-tetrahydrocannabinol depressed GABA cell activity, therefore downstream dopam

84 that endogenously-released 2-AG retrogradely depresses GABA input from the MSDB.

85 oups stabilize the surface of Li(2)MnO(3) by depressing gas release and side reactions with the elect

86 enome editing confirmed its functionality in depressing GATA6 expression and the efficiency of pancre

87 The Australian depressed group reported significantly greater interpers

88 At baseline, relative to controls, the depressed group showed lower reward learning (P = 0.02),

89 The depressed group then received open-label pramipexole tre

90 ect on the posterior cingulate cortex in the depressed group, with self-appraisal causing significant

91 ntified three neurocognitive subtypes in the depressed group.

92 However, the three depressed groups did not differ culturally.

93 ctivation levels were seen in ND compared to depressed groups, and this difference was maintained at

94 conditions, at least when the population is depressed, has probably contributed to the persistence o

95 Twenty-four patients with LLD and 27 non-depressed healthy control subjects (HCs) of comparable a

96 ed to cardiac ischemia/reperfusion injury to depress heart function, followed by 4 weeks pacing at th

97 D had significantly (P<0.05 versus baseline) depressed HRV (SD of all pulse-to-pulse intervals over a

98 iation, causing increased HSC DNA damage and depressed HSC recovery over time.

99 ferentially expressed genes in the brains of depressed humans and display complex region- and sex-spe

100 nset and sustained antidepressant effects in depressed humans has led to a renewal of interest in the

101 s access can present for port placement with depressed immune function as a result of their treatment

102 eukoencephalopathy (PML) in individuals with depressed immune status.

103 r risk of severe COVID-19 infection due to a depressed immune system and high-risk underlying comorbi

104 succinate dehydrogenase [COX/SDH]-ratio) was depressed in ILD (median = 0.10,) compared with controls

105 tivity, and dynamic range of V2 neurons were depressed in infants compared with adults.

106 restingly, GATA6 protein expression remained depressed in pancreatic progenitor cells even after corr

107 trials revealed B. barbus growth rates were depressed in sympatry with L. idus.

108 in decay, the yield of SOZs is significantly depressed, indicating reactions of the Criegee intermedi

109 nd white matter integrity (n = 1089) between depressed individuals and controls in the subset of 8590

110 hough several studies suggest impairments in depressed individuals in single tasks, there has been no

111 ne function may hold promise for identifying depressed individuals likely to respond favourably to do

112 wards predicted better reward learning among depressed individuals receiving amisulpride as well as a

113 f depression in adults and adolescents, with depressed individuals showing blunted (hyporeactive) str

114 and iii) neurobiological characteristics of depressed individuals who respond to mindfulness.

115 act of impulsivity during decision-making in depressed individuals with and without suicidal behavior

116 Depressed individuals with BD (n = 18), MDD (n = 23), an

117 depression as well as in postmortem brain of depressed individuals.

118 motional content from midnight to dawn among depressed individuals.

119 n; ii) the effect of MT on depressed and non-depressed individuals; and iii) neurobiological characte

120 logical functions that impact health through depressing inflammation.

121 lack of agreement among algorithms were more depressed initial MD (P < 0.01) and older age at first a

122 on optical mapping in explanted human hearts depress intranodal SAN conduction, which worsens during

123 t caregivers are more likely to report being depressed, it is crucial to identify whether poor sleep

124 D visit, there was a significant increase in depressed language (Cohen's d = 0.238), and a decrease i

125 ed to detect colorectal polyps, but flat and depressed lesions are often missed.

126 were employed, less severely and chronically depressed, less anxious, not experiencing complicated gr

127 ebo group due to acute myeloid leukaemia and depressed level of consciousness.

128 juana users, while Rothia, which is found at depressed levels on HNSCC mucosa, was high.

129 MCD+B diet worsened hyperhomocysteinemia and depressed liver methylation potential 8-fold compared wi

130 l performance of the "native" S. zebrina and depress local populations Geographic field surveys were

131 wed an enlarged LV with moderate to severely depressed LV function (EF, 28%; SF, 14%).

132 ene impairs lysosomal acidification, thereby depressing lysosomal hydrolytic activities and turnover

133 ts were applied to 927 male controls and 986 depressed males, and 1199 female controls and 1689 depre

134 failure (64% versus 78%, P<0.001), had less-depressed mean left ventricular fractional shortening z

135 d reperfusion with 155 mM [Na(+)](o) further depressed mechanical function.

136 (HCN2) are decreased in ChIs of NAc shell in depressed mice.

137 dicated cows consuming RS diets may have had depressed milk protein synthesis because these animals h

138 nformational assemblies of MinD in vitro and depresses Min function in vivo during periods of reduced

139 in alcoholic animals is also associated with depressed mitochondrial fusion.

140 Patients were moderately depressed (Montgomery-Asberg Depression Rating Scale=30+

141 of the PHQ-9 (which assess the frequency of depressed mood and anhedonia) and can be used as a first

142 search by exploring the relationship between depressed mood and cognitive ToM, specifically visual pe

143 ) was administered with hourly assessment of depressed mood and proinflammatory cytokines (interleuki

144 ng GLM analyses, including interactions with depressed mood and sex across disorders.

145 dietary supplement reduces vulnerability to depressed mood at postpartum day 5, the typical peak of

146 d MAO-A activity eliminates vulnerability to depressed mood during the peak of PPB.

147 articipants (36%) experienced an increase in depressed mood from baseline to 2 h post endotoxin, when

148 ing the MIP, there was a robust induction of depressed mood in the control group, but no effect in th

149 tome profiles predicted inflammation-induced depressed mood in volunteers who received low-dose intra

150 imuli to alter proinflammatory responses and depressed mood is not known.

151 disorder, we examined whether post-endotoxin depressed mood is predicted by baseline activity of TFs

152 Inflammation-induced depressed mood is predicted by peripheral transcriptome

153 severity was quantitated by the elevation in depressed mood on a visual analog scale following the sa

154 ns were observed in women with low levels of depressed mood or men.

155 order characterized by episodes of manic and depressed mood states and associated with cortical brain

156 Self-reported depressed mood was assessed using the Profile of Mood St

157 ckness response revealed that post-endotoxin depressed mood was predicted by increased baseline activ

158 d to placebo, endotoxin-induced increases of depressed mood were moderated by baseline levels of perc

159 underlying dimensions measured by the EPDS: depressed mood, anxiety, and anhedonia.

160 In conclusion, death wishes, depressed mood, loss of interest, and pessimism constitu

161 Death wishes, depressed mood, loss of interest, and pessimism had the

162 Our results revealed that in women with high depressed mood, lower cardiovagal activity in response t

163 e presents to her primary care provider with depressed mood, negative feelings about herself, poor sl

164 eases in central acetylcholine could lead to depressed mood.

165 modify vulnerability to inflammation-induced depressed mood.

166 ons but remain attached to the basal lamina, depressing more central neighbours to "telescope" the ep

167 nformation for understanding why children of depressed mothers may be more vulnerable to depression t

168 between myocardial injury, heart failure and depressed myocardial energetics, little is known about u

169 100), high-risk healthy (n = 2023), remitted depressed (n = 401) and currently depressed children (n

170 Remitted depressed (n=48) and healthy volunteers (n=48) were rand

171 ion of Kv1.2 in the plasma membrane, thereby depressing NAcSh MSNs firing.

172 ar) abnormalities, midface hypoplasia with a depressed nasal bridge, metaphyseal striations, and disp

173 slightly elevated mortality rates and mildly depressed natality rates of biomedical journals, but tha

174 ed on self-report, 3 groups were formed: non-depressed (ND), depressed before but not after MT (respo

175 ed Ca(2+) entry revealed that PMCA4 markedly depressed near-membrane Ca(2+) concentrations, particula

176 The depressed neuromuscular transmission in R6/2 muscle may

177 Amphetamine depresses neurotransmission through stimulation of astro

178 OO extract depressed neutrophil stimulation of CD4+ T cells in the

179 activity; however, coexpression with PMCA4a depressed NFAT.

180 cinal leech), endocannabinoids were found to depress nociceptive synapses, but enhance non-nociceptiv

181 al control subjects, depressed suicides, and depressed nonsuicides (human males/females).

182 s in acetylation from depressed suicides and depressed nonsuicides compared with controls.

183 ion between control, depressed suicides, and depressed nonsuicides, plasma membrane-associated tubuli

184 icidal depressed (SD) patients, non-suicidal depressed (NSD) patients, and HCs significantly differed

185 and decrease of PBL height, and thus further depressing of aerosol and water vapour in a very shallow

186 Finally, depressing OFC-DMS pathway with a high frequency stimula

187 psychotherapy available to large numbers of depressed older adults.

188 ced by amino acid substitutions in ENaC that depress open probability and was precluded by proteolyti

189 ow initial PPR ("strong" synapses) tended to depress or did not change.

190 tion for mitigating suicidal ideation in all depressed outpatients with insomnia, they suggest that c

191 Opioid receptor activation profoundly depresses PAG and RMTg inhibitory synapses but prevents

192 e Purkinje cells, evoking complex spikes and depressing parallel fibre synapses.

193 April 2007 to March 2011) among offspring of depressed parents in the general community.

194 Depressed participants (n = 51) had ecological momentary

195 Depressed participants experiencing decreased appetite h

196 ling and brain activity to food cues between depressed participants experiencing increased (N = 23) o

197 In contrast, depressed participants experiencing increased appetite e

198 control participants receiving amisulpride), depressed participants receiving amisulpride exhibited i

199 Relative to depressed participants receiving placebo (and control pa

200 led an atypical pattern of connectivity in a depressed patient subset that would be overlooked in gro

201 Twenty-three depressed patients (14 females, age: 50.17 +/- 12.72 yea

202 In 65 unmedicated depressed patients 15-min resting-state EEGs were record

203 c abnormalities have been widely reported in depressed patients and animal models.

204 eased during the admission in this sample of depressed patients and early patterns of actigraphically

205 line causal connectivity differences between depressed patients and healthy controls were also evalua

206 innate and adaptive immune systems occur in depressed patients and hinder favorable prognosis, inclu

207 -13 produces rapid antidepressant actions in depressed patients and in preclinical rodent models.

208 ted disorders remain unclear, but studies in depressed patients and rodent models are beginning to yi

209 ck gene expression, corticoptropin levels in depressed patients and the temporal light intensity patt

210 ants offer therapeutic benefit, about 35% of depressed patients are not adequately treated, creating

211 Therefore, depressed patients faced an even higher ICD risk when re

212 The sparse comorbidity map confirmed that depressed patients frequently suffer from both psychiatr

213 heral and central markers of inflammation in depressed patients has not been established.

214 gested that posterior hippocampal volumes in depressed patients may be associated with antidepressant

215 across DMN nodes, as previously reported in depressed patients on average.

216 Depressed patients present with motor activity abnormali

217 take months to take full effect, and ~30% of depressed patients remain treatment resistant.

218 pharmacological therapies, only the half of depressed patients respond to currently available treatm

219 Depressed patients show abnormalities in brain connectiv

220 To test this hypothesis, depressed patients were pretreated with rapamycin, an mT

221 der risk, and impaired emotion regulation in depressed patients with a history of suicide attempts.

222 eutics can produce antidepressant effects in depressed patients with primary inflammatory disorders t

223 s rapid and robust antidepressant effects in depressed patients within hours of administration, often

224 action in depressed and treatment-resistant depressed patients within hours.

225 ed changes in HDAC1 expression in the NAc of depressed patients without antidepressant treatment in l

226 apid and sustained antidepressant actions in depressed patients, addressing a major unmet need for th

227 we first discuss sex differences observed in depressed patients, as well as animal models that reveal

228 Depressed patients, even after remission, might also ben

229 irments in Theory of Mind (ToM) abilities in depressed patients, particularly in relation to tasks in

230 regulated homeostatic biological pathways in depressed patients, such as increased inflammation and d

231 d TPI identified an increased BTP in midlife depressed patients, suggesting early and subtle vascular

232 s aversion correlated with each other in the depressed patients, suggesting that a common pathophysio

233 on were partially abolished in more severely depressed patients.

234 f the dysregulated inflammatory responses in depressed patients.

235 pportunities for restoring energy balance in depressed patients.

236 in at-risk populations or its recurrence in depressed patients.

237 ircadian rhythms in the postmortem brains of depressed patients.

238 tivity and network function in the brains of depressed patients.

239 ent response were measured in 72 unmedicated depressed patients.

240 e agonists should thus be used cautiously in depressed PD patients.

241 luence comprises a facilitatory centre and a depressing peripheral zone, which together shape the inf

242 ption of inflammatory genes and consistently depressed phagocytosis of amyloid-beta1-42 (Abeta) by mo

243 In vivo, depressing PKG activity lowers CHIP-S20 phosphorylation

244 ions, mss+ both increases male frequency and depresses population growth.

245 Block of mito-Ca(2+) uptake in mature cells depresses presynaptic-Ca(2+) influx and impacts synapse

246 in the MBs yielded premature habituation and depressed PSD-LTM.

247 ricular filling pressures with exercise, and depressed pulmonary artery vasodilator reserve.

248 All new analogues show depressed pyrogenicity in both free (micellar) state and

249 l energy production via glucose oxidation by depressing pyruvate dehydrogenase complex activity.

250 nhibition of oxidative phosphorylation alone depressed recovery from vesicle depletion.

251 roteomic differences as a function of state (depressed/remitted) or number of previous episodes.

252 ce infection (prior procedures [P], age [A], depressed renal function [D], immunocompromised [I], and

253 Suicidal depressed (SD) patients, non-suicidal depressed (NSD) pa

254 It is suggested that a deceivingly depressed selectivity (1 < kappaobs < kA/kB), caused by

255 Lower GCS score, midline shift, depressed skull fracture, and epidural hematoma are key

256 vidual symptom trajectories, such as feeling depressed, social, and calm and hearing voices.

257 infrared thermal emissivity must be zero to depress spontaneous blackbody irradiation (2.5-25 [Formu

258 transcriptional control of SERCA2 activity, depressed SR Ca(2+) sequestration, enhanced trans-sarcol

259 of depression and which represent a current depressed state.

260 ision-making performance alone could predict depressed status out-of-sample with 72% accuracy.

261 accounted for unique variance in predicting depressed status.

262 This distinct mode of c-Cbl recognition depresses steady-state expression of LynA in macrophages

263 Trains of EPSCs (5 Hz) depressed strongly throughout development, whereas conve

264 ors of cognition across the entire sample of depressed subjects and HR.

265 Compared to the control group, depressed subjects were significantly more active from 7

266 e significantly down-regulated in cells from depressed subjects.

267 ymphoblast cell lines (LCLs) from normal and depressed subjects; the latter divided into remitters an

268 um) and block by the peptide inhibitor blood depressing substance I (BDS-I).

269 l spinal neurons, blockade of Kv3.4 by blood depressing substance II suppresses axon growth via an in

270 Postmortem tissue derived from depressed suicide brain showed increased Galpha(s) in li

271 were pairwise correlated specifically in the depressed suicide group, but not in the control group.

272 vels are increased in the post-mortem PFC of depressed suicide subjects relative to matched controls.

273 ed significant decreases in acetylation from depressed suicides and depressed nonsuicides compared wi

274 ains in tissue from normal control subjects, depressed suicides, and depressed nonsuicides (human mal

275 nges in tubulin acetylation between control, depressed suicides, and depressed nonsuicides, plasma me

276 NTD exhibit increased mobility in synapses, depress synaptic transmission and are unable to sustain

277 ractile force in normal hearts and models of depressed systolic function, but the structural basis of

278 In comparison, 1-hydroxymidazolam did not depress the cortical network activity at low nanomolar c

279 reconditioning with cryoprotective agents to depress the freezing point of the liver tissue.

280 rinking isotropic domains where they locally depress the transition temperature.

281 The hurricanes depressed the densities of juvenile and adult octocoral

282 A concentration of 30% (w/w) Pluronic F127 depressed the freezing point of an electrolyte comprisin

283 of melittin on membrane bending modulus and depressed the T(Phi) of the cells.

284 n-insertion potential in the cathode, and it depresses the anion-insertion potential in the anode, th

285 Consistently, mPges-1 deletion depresses the arteriolar dilatory response to I/R in viv

286 nase 3-hydroxybenzoate 6-hydroxylase (3HB6H) depresses the pK(a) of the bound substrate analog 4-fluo

287 incubated with faecal bacteria 3-DG strongly depressed this microbial community.

288 We then show that carbachol consistently depresses this input and that this effect is presynaptic

289 ase produces a frustrated smectic phase with depressed transition temperature, and the characteristic

290 ecting to CA3, sprouted mossy fiber synapses depress upon repetitive activation.

291 nts and young adults (14-24 y, 25 clinically depressed) using a multivariate statistical framework, b

292 c silencing of natural GAD65LH cell activity depresses voluntary locomotion, and that GAD65LH cell ov

293 extensive presence of perchlorate salts that depress water's freezing point to ~-60 degrees C, our ap

294 viduals lose their appetite when they become depressed, while others eat more.

295 more powerful than distal inputs and fail to depress with repeated stimulation.

296 hibit MOC action potentials, but this effect depresses with repeat activation.

297 Since recombination is depressed within genes and between distal regulatory ele

298 of cognitive vulnerability and resilience in depressed youth, which may inform the identification of

299 natures in a large cross-sectional sample of depressed youth.

300 ss drove a phase shift to high mortality and depressed zoobenthic immobilized carbon stocks, which ha