ライフサイエンスコーパス: designer

1 nforcement learning-based chemical graph-set designer.

2 in which some action is chosen by the study designer.

3 ; and attract a diverse community of product designers.

4 nd of factors outside the control of program designers.

5 We used a "designer" AAV, AAV2/Anc80L65, in which the main capsid p

6 ing the brain's connectome via gene-targeted designer activators and repressor proteins.

7 We injected into NAc variants of a new designer adeno-associated virus that permits robust retr

8 Designers and funders of payments for ecosystem services

9 accountability for AI remains with its human designers and operators for the foreseeable future.

10 stems are developed to inform policy makers, designers, and operators.

11 rect utility for town councilors, smart-city designers, and other urban decision makers.

12 arison of UV LEDs by consumers, researchers, designers, and regulators.

13 These findings suggest that endograft designers are free to construct any extreme case-studies

14 s story as it is the ability to generate the designer azadipyrromethene that opens the door to exciti

15 In this study, flubromazepam, a recognized designer benzodiazepine since 2012, was targeted for syn

16 ization data for positional isomers of known designer benzodiazepines are widely nonexistent.

17 Designer benzodiazepines have recently appeared in many

18 their promise for the future development of designer biocatalysis for the selective late-stage modif

19 ith which to engineer the next generation of designer biocatalysts.

20 led radical copolymerization of styrene with designer boron or phosphorus containing monomers.

21 heir knowledge system can help institutional designers build more efficient and effective institution

22 ience to generate precise disease models and designer cell samples for personalized therapeutics will

23 The unorthodox use of aerobic enzymes in designer cellulosome machinery effects simultaneous degr

24 type enzyme and properly integrated into the designer cellulosome.

25 Recently, designer cellulosomes have been developed to incorporate

26 quences and the introduction of thousands of designer changes may affect genome organization and pote

27 rane pores opens the door to the creation of designer channels and pores for a wide variety of applic

28 gues use a laminin polymerization-competent, designer chimeric BM protein in vivo to restore function

29 We further used designer chromatin inhibitors to probe the geometric con

30 In this study, we utilize designer chromatin substrates to demonstrate that propag

31 By using semisynthetic 'designer' chromatin containing H2B-Ub bearing a site-spe

32 on in liquid crystals (LCs) in patterns with designer complexity.

33 graphs generated by RAG Sampler, and (c) RAG Designer: designs sequences that fold onto novel RNA mot

34 TfR1) in established human cell lines with a designer disulfide FRET probe.

35 Designer DNA architectures with nanoscale geometric cont

36 The ability to rapidly and robustly generate designer DNA molecules in an autonomous manner should ha

37 Designer DNA nanoparticles are constructed from double-s

38 Here we demonstrate a designer DNA nanostructure that can act as a template to

39 We benchmark and optimize pPAINT using designer DNA nanostructures and demonstrate its cellular

40 y designer receptor exclusively activated by designer drug (DREADD) chemogenetic technology, we found

41 designer receptors exclusively activated by designer drug (DREADD) in the hypoglossal motorneurons.

42 esigner receptors exclusively activated by a designer drug (DREADD), promotes anxiety-like behavior.

43 Designer receptors exclusively activated by designer drug (DREADDs) are a novel tool with the potent

44 designer receptors exclusively activated by designer drug (DREADDs) as a means of bidirectionally mo

45 d designer receptor exclusively activated by designer drug (G(i)-DREADD) approach.

46 designer receptor exclusively activated by a designer drug (Gq-DREADD) in all inhibitory interneuron

47 d designer receptor exclusively activated by designer drug also led to the elevation of AMPAR functio

48 d designer receptor exclusively activated by designer drug augmented CD8(+) T(EM) bone marrow accumul

49 designer receptor exclusively activated by a designer drug in PVT neurons, we show that the PVT is ce

50 , designer receptor exclusively activated by designer drug technology to specifically manipulate CA1

51 graft-derived interneurons was silenced by a designer drug while using donor hiPSC-MGE cells expressi

52 rs," which are exclusively activated by the "designer drug" clozapine N-oxide (CNO).

53 designer receptor exclusively activated by a designer drug) in dACC neurons, and examined the effects

54 (designer receptor exclusively activated by designer drug) injected into the rostral ventrolateral m

55 Designer Receptor Exclusively Activated by a Designer Drug) knock-in mouse line to manipulate intrace

56 (designer receptor exclusively activated by designer drug) receptor hM4Di in sensorimotor cortex and

57 (designer receptor exclusively activated by designer drug).

58 (designer receptors exclusively activated by designer drug).

59 r designer receptor exclusively activated by designer drug-directed specific increases in CA1 excitat

60 y designer receptor exclusively activated by designer drugs (DREADD) hM3Dq was used to induce PFC act

61 designer receptors exclusively activated by designer drugs (DREADD) technology to specifically activ

62 designer receptors exclusively activated by designer drugs (DREADD) viruses into the hypothalamus of

63 'designer receptors exclusively activated by designer drugs (DREADD)' approach, and ChAT-IRES-Cre mic

64 Designer Receptors Exclusively Activated by Designer Drugs (DREADD)-based chemogenetic tools are now

65 designer receptors exclusively activated by designer drugs (DREADD).

66 designer receptors exclusively activated by designer drugs (DREADDs) afford remotely reversible cont

67 Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are a popular chemogenetic tech

68 ry Designer Receptors Exclusive Activated by Designer Drugs (DREADDs) before cisplatin treatment.

69 designer receptors exclusively activated by designer drugs (DREADDs) confirmed that G(i) differentia

70 y designer receptor exclusively activated by designer drugs (DREADDs) constructs expressed in GABAerg

71 designer receptors exclusively activated by designer drugs (DREADDs) has made it possible to dissect

72 designer receptors exclusively activated by designer drugs (DREADDs) induced A1R-mediated synaptic d

73 designer receptors exclusively activated by designer drugs (DREADDs) or by the treatment with glutam

74 designer receptors exclusively activated by designer drugs (DREADDs) specifically in the adrenal cor

75 designer receptors exclusively activated by designer drugs (DREADDs) technology, we found that stimu

76 designer receptors exclusively activated by designer drugs (DREADDs) to determine the anatomic and f

77 Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) to GABA neurons in the VTA of w

78 designer receptors exclusively activated by designer drugs (DREADDs) to selectively activate or inhi

79 designer receptors exclusively activated by designer drugs (DREADDs) were delivered after 4-weeks of

80 designer receptors exclusively activated by designer drugs (DREADDs) were infused and subsequently a

81 Designer Receptors Exclusively Activated by Designer Drugs (DREADDs)) provides a reliable and robust

82 designer receptors exclusively activated by designer drugs (DREADDs), behavioral pharmacology, elect

83 designer receptors exclusively activated by designer drugs (DREADDs), exposure to a novel environmen

84 designer receptors exclusively activated by designer drugs (DREADDs), through virtual lesioning of a

85 designer receptors exclusively activated by designer drugs (DREADDs), uses a non-endogenous actuator

86 designer receptors exclusively activated by designer drugs (DREADDs), we show in two AD-like mouse m

87 al cortex regulates impulsivity by using the designer drugs (DREADDs)-based chemogenetic tools.

88 designer receptors exclusively activated by designer drugs (DREADDs)-based manipulation of neuronal

89 designer receptors exclusively activated by designer drugs (DREADDs)-mediated synaptic silencing abl

90 designer receptors exclusively activated by designer drugs (DREADDs).

91 designer receptors exclusively activated by designer drugs (DREADDs).

92 designer receptors exclusively activated by designer drugs (DREADDs).

93 q-coupled receptors exclusively activated by designer drugs (Gq-DREADD) during fear extinction had no

94 (designer receptors exclusively activated by designer drugs [DREADD]) inhibition of tachykininergic n

95 e presented, including the identification of designer drugs and chemical derivatives not present in t

96 designer receptors exclusively activated by designer drugs excitation or inhibition of the VP.

97 designer receptors exclusively activated by designer drugs in female rats throughout repeated restra

98 ass-specific DNA aptamer against a family of designer drugs known as synthetic cathinones.

99 n verification, and retrospective testing of designer drugs that elude conventional drug tests.

100 Designer receptors exclusively activated by designer drugs were used to inhibit orexin activation th

101 (designer receptors exclusively activated by designer drugs) (Gi) to amplify and reduce transmission,

102 (designer receptors exclusively activated by designer drugs) during a variety of cocaine-seeking beha

103 (designer receptors exclusively activated by designer drugs) is widely used for remote manipulation o

104 (designer receptors exclusively activated by designer drugs) mimicked the antidepressant-like respons

105 (designer receptors exclusively activated by designer drugs) resulted in reduced PPI further demonstr

106 (designer receptors exclusively activated by designer drugs) selectively in mPFC neurons projecting t

107 (designer receptor exclusively activated by designer drugs) strategy to manipulate vHPC-NAc excitabi

108 (designer receptors exclusively activated by designer drugs) system in which a mutated muscarinic G p

109 (designer receptors exclusively activated by designer drugs) technology by creating ROSA26-based knoc

110 (designer receptor exclusively activated by designer drugs) was used to inhibit glutamatergic projec

111 (designer receptor exclusively activated by designer drugs)-based inhibition of the mPFC-AcbSh pathw

112 (designer receptor exclusively activated by designer drugs)-mediated causal approach to test the hyp

113 (designer receptor exclusively activated by designer drugs)-mediated chemogenic activation/inhibitio

114 (designer receptor exclusively activated by designer drugs).

115 cannainol, as well as synthetic derivatives (designer drugs).

116 (designer receptors exclusively activated by designer drugs).

117 apidly reacting to emerging threats, such as designer drugs, biological therapeutic agents, and techn

118 he specific detection of a family of illicit designer drugs, the synthetic cathinones, with customize

119 ides a powerful path towards the creation of designer electronic devices.

120 re metallic substrates strongly screen their designer electronic properties and limit further applica

121 As the designer enforces a controllable break in the symmetry,

122 As part of the effort to build a designer eukaryotic genome, yeast synthetic chromosome X

123 copic observations of recombinantly produced designer FADGDH confirmed the intramolecular electron tr

124 An enzyme electrode with the immobilized designer FADGDH showed an increase in current immediatel

125 Therefore, the designer FADGDH was confirmed to be a novel GDH that pos

126 In this study, a designer FADGDH was constructed by fusing Aspergillus fl

127 for the improvement of the DET properties of designer FADGDH.

128 Predicted designer flow prescriptions indicate significant opportu

129 illustration of theoretical predictions that designer flows can offer multiple ecological and societa

130 ty, properties that are on par with those of designer gels.

131 rrangement and remodelling of liposomes with designer geometry: all of which are exquisitely controll

132 ith transgenic mice expressing a G(q)-linked designer GPCR selectively in SKM cells demonstrated that

133 The development of designer GPCRs known as designer receptors exclusively a

134 We used the predictor to engineer designer GPCRs selectively coupled to G(12).

135 Activation of SN DA neurons with designer Gq-coupled receptors exclusively activated by d

136 Enhancing photosynthesis using designer, green and sustainable materials offers an attr

137 ther sectors, such as social welfare, policy designers have purposefully adjusted the costs of progra

138 Vaccine designers have sought to restrict the conformation of th

139 nterest in application of these materials as designer heterogeneous catalysts.

140 al control of inversion-symmetry breaking in designer heterostructures of oxides and other material c

141 temporal inhibition of translation by using designer IDPs that exhibit tunable phase behavior.

142 This feedback creates a designer illumination that generalizes the field of adap

143 This poses a paradox for urban designers in adopting expansion or densification as a gr

144 A designer Josiphos ligand promotes the generation of chir

145 nsive approach for creating robust, elastic, designer Lunar and Martian regolith simulant (LRS and MR

146 form on which to develop a new generation of designer magnets.

147 al user interfaces (GUIs) generated with App Designer, making it an easy-to-use application for quick

148 Synthetic approaches to prepare designer materials that localize deformation, by combini

149 y opens new avenues for facile syntheses of "designer materials" where chemical components from discr

150 for encoding highly complex information into designer metasurfaces, thus having the potential to driv

151 Inspired by the concept of designer metasurfaces, we demonstrate a novel amplitude-

152 Here we demonstrate that vitamin E-derived designer micelles, originally developed for use in synth

153 ch is called a scaffold strand, into various designer nanoscale architectures.

154 emtosecond spatiotemporal current control in designer nanosystems.

155 otential of a nonhypotensive pGC-A activator/designer natriuretic peptide, CRRL269, in a short-term,

156 We demonstrate that dsRNA can be loaded on designer, non-toxic, degradable, layered double hydroxid

157 Here we demonstrate the use of multiple designer nucleases and variant-aware library design to i

158 The functional effect of a gene edit by designer nucleases depends on the DNA repair outcome at

159 Designer nucleases have gained widespread attention for

160 Delivery of these designer nucleases into organisms induces various geneti

161 Genome editing by designer nucleases is a rapidly evolving technology util

162 Genome editing with designer nucleases such as TALEN and CRISPR/Cas enzymes

163 d destruction of the mitochondrial genome by designer nucleases(9,10).Here we describe an interbacter

164 monly used tool to assess genomic editing by designer nucleases.

165 pproach, which is of benefit to analysts and designers of complex systems and networks.

166 nd flight in insects and pose a challenge to designers of miniature biomorphic aircraft.

167 re-envisioning the niche as an enabler, not designer, of cell fate.

168 Research on two-dimensional designer optical structures, or metasurfaces, has mainly

169 an essential first step in the creation of a designer organelle.Designer organelles could allow the i

170 step in the creation of a designer organelle.Designer organelles could allow the isolation of synthet

171 The development of 'designer' organelles could be a key strategy to enable f

172 Based on their selectivity, these designer pairs will bolster multicomponent imaging and e

173 the engineering of multicompartment-spanning designer pathways that can be utilized to control downst

174 The histidine-rich designer peptide LAH4-L1 exhibits antimicrobial and pote

175 d or otherwise, and typically results in the designer performing electromagnetic simulations of a lar

176 physiology and biochemistry, and engineering designer phages for diverse applications.

177 on that failed with known ligands for Ni and designer phosphines for Pd.

178 greatly expand possibilities for developing designer photocatalytic substrates.

179 Such designer photonic media with complete control over the o

180 HPAs holds great potential for production of designer platelets for diagnostic, investigative, and, u

181 s a set, allow a wide range of stakeholders (designers, policy-makers, and vehicle manufacturers and

182 bility of engineered biocatalysts to produce designer products at high carbon and energy efficiency w

183 orporate particles with the well-established designer properties of MOFs and, therefore, increase the

184 discovery of sequence defined polymers with designer properties, such as oligonucleotide binding.

185 l insights and enable new applications (e.g. designer protein therapeutics).

186 One such designer protein-degronLOCKR, which is based on 'latchin

187 Here, we show that a designer protein-deprived diet enriched in free essentia

188 We thereby demonstrate that Ub designer proteins pose a unique new generation of crysta

189 Production of designer proteins with Sec (selenoproteins) at desired p

190 h offers a powerful tool to engineer diverse designer proteins.

191 s of these compounds, indicating promise for designer quantum systems synthesized from the bottom-up.

192 tic approach expressing the inhibitory hM4Di designer receptor exclusively activated by a designer dr

193 e virally expressed inhibitory hM4Di DREADD (designer receptor exclusively activated by a designer dr

194 Here we generated a DREADD (Designer Receptor Exclusively Activated by a Designer Dr

195 We virally expressed an excitatory designer receptor exclusively activated by a designer dr

196 eteroreceptor signaling using a G(i)-coupled designer receptor exclusively activated by designer drug

197 chain reaction, calcium imaging, and DREADD (designer receptor exclusively activated by designer drug

198 e basolateral amygdala (BLA) using a DREADD (designer receptor exclusively activated by designer drug

199 olution approaches combining mouse genetics, designer receptor exclusively activated by designer drug

200 idal neurons with a CaMKII-driven Gq-coupled designer receptor exclusively activated by designer drug

201 ive deficits that could be rescued by either designer receptor exclusively activated by designer drug

202 nally, we used an intersecting viral DREADD (designer receptor exclusively activated by designer drug

203 The excitatory designer receptor exclusively activated by designer drug

204 virus (AAV)-expressing Cre-dependent DREADD (designer receptor exclusively activated by designer drug

205 sconnected these regions using hM4Di-DREADD (designer receptor exclusively activated by designer drug

206 ifferent experimental approaches, especially designer receptor exclusively activated by designer drug

207 sympathetic outflow using Gi-coupled DREADD (designer receptor exclusively activated by designer drug

208 DREADD (designer receptor exclusively activated by designer drug

209 l ganglion activity by activating Gq-coupled designer receptor exclusively activated by designer drug

210 a projection-specific Cre-dependent DREADD (designer receptor exclusively activated by designer drug

211 bition using either excitatory or inhibitory designer receptor exclusively activated by designer drug

212 A chemogenetic approach (designer receptor exclusively activated by designer drug

213 o this end, we expressed the Galphai-coupled designer receptor hM4D in adult striatopallidal neurons

214 RP neurons, and activation of the inhibitory designer receptor hM4Di on AgRP neurons did not affect s

215 of GABA release from PV neurons through the designer receptor hM4Di selectively expressed in PV-cont

216 Designer receptor stimulation of G(q) signaling, but not

217 Therefore, here we used designer receptor-mediated inactivation of OFC-->BLA or

218 We used viral-mediated gene transfer of designer receptors (DREADDs) to activate vmPFC neurons a

219 in combination with Cre-dependent inhibitory Designer Receptors Exclusive Activated by Designer Drugs

220 ons using hM3Dq, but neither hM4Di nor rM3Ds designer receptors exclusively activated by a designer d

221 in mice with C-FOS immunohistochemistry and designer receptors exclusively activated by designer dru

222 Designer Receptors Exclusively Activated by Designer Dru

223 while using donor hiPSC-MGE cells expressing designer receptors exclusively activated by designer dru

224 ine neuron G-protein signaling with DREADDs (designer receptors exclusively activated by designer dru

225 Here, using designer receptors exclusively activated by designer dru

226 The chemogenetic technology DREADD (designer receptors exclusively activated by designer dru

227 common chemogenetic neuromodulatory system, designer receptors exclusively activated by designer dru

228 CaMKII-driven inhibitory Gi-coupled designer receptors exclusively activated by designer dru

229 al activity with distinct stimuli, including designer receptors exclusively activated by designer dru

230 Inhibition of orexins using designer receptors exclusively activated by designer dru

231 Designer receptors exclusively activated by designer dru

232 chemogenetic locus coeruleus activation via designer receptors exclusively activated by designer dru

233 ection strategies, pharmacologic rescue, and designer receptors exclusively activated by designer dru

234 ved using chemogenetic approach by deploying designer receptors exclusively activated by designer dru

235 The development of designer GPCRs known as designer receptors exclusively activated by designer dru

236 glutamatergic vCA1 to mPFC projections using designer receptors exclusively activated by designer dru

237 The chemogenetic technology designer receptors exclusively activated by designer dru

238 an M3 muscarinic receptor (hM3Dq), a type of designer receptors exclusively activated by designer dru

239 In this issue of the JCI, Gaykema et al. use designer receptors exclusively activated by designer dru

240 s in vivo, we harnessed the power of DREADD (designer receptors exclusively activated by designer dru

241 modulation of neuroanatomical circuits using designer receptors exclusively activated by designer dru

242 nstrated that our chemogenetic approach (eg, Designer Receptors Exclusively Activated by Designer Dru

243 nt with this, astrocyte activation with G(q) designer receptors exclusively activated by designer dru

244 netic method in mice and rats is the DREADD (designer receptors exclusively activated by designer dru

245 ent and reacquisition of alcohol seeking via designer receptors exclusively activated by designer dru

246 Using viral-mediated delivery of designer receptors exclusively activated by designer dru

247 elevant Ca(2+) influx by the introduction of designer receptors exclusively activated by designer dru

248 eneration of transgenic mice with Gq-coupled designer receptors exclusively activated by designer dru

249 ion of the vHipp-mPFC pathway using DREADDs (designer receptors exclusively activated by designer dru

250 d this region using CaMKII-driven Gs-coupled designer receptors exclusively activated by designer dru

251 um using the pharmacogenetic technique, the 'designer receptors exclusively activated by designer dru

252 This study evaluates the efficacy of designer receptors exclusively activated by designer dru

253 ed from hPSCs engineered to express DREADDs (designer receptors exclusively activated by designer dru

254 Designer Receptors Exclusively Activated by Designer Dru

255 Designer receptors exclusively activated by designer dru

256 approach to express G(i/o)-coupled DREADDs (designer receptors exclusively activated by designer dru

257 In addition, using designer receptors exclusively activated by designer dru

258 ng stimulatory (hM3Dq) or inhibitory (hM4Di) designer receptors exclusively activated by designer dru

259 stabilized step function opsin) and DREADDs (designer receptors exclusively activated by designer dru

260 expression of hM3Dq, the excitatory DREADDs (designer receptors exclusively activated by designer dru

261 Chemogenetic (designer receptors exclusively activated by designer dru

262 viral vector approach to restrict activating Designer Receptors Exclusively Activated by Designer Dru

263 To determine this, we injected Cre-dependent designer receptors exclusively activated by designer dru

264 rgic neurons in the medial septum by DREADD (designer receptors exclusively activated by designer dru

265 er, chemogenetic control of G(i) and G(q) by designer receptors exclusively activated by designer dru

266 This study combined designer receptors exclusively activated by designer dru

267 transgene strategy to express and stimulate designer receptors that mimicked mGluR5 signaling throug

268 DREADD technology posits the use of "designer receptors," which are exclusively activated by

269 ngineered ribosome may have on the cell, the designer ribosome needs to be functionally isolated from

270 revious study in Arabidopsis that employed a designer RNA-binding protein as a psbA RNA affinity tag.

271 in vitro directed evolution of proteins with designer single-molecule conformational phenotypes of in

272 At carbon surfaces, designer sites for interfacial PCET can be incorporated

273 Herein, we describe a designer small molecule, Cugamycin, that recognizes the

274 ngineered receptors exclusively activated by designer small molecules enable manipulation of specific

275 pramolecular self-assembly enables access to designer soft materials that typically exhibit high-symm

276 enomes using the online Primal Scheme primer designer software.

277 e promising for applications as inexpensive "designer" solvents exhibiting a host of tunable physicoc

278 ogy is adopted to prepare a bio-conduit with designer structures for peripheral nerve regeneration.

279 Directed crystal growth on designer substrates has the potential to enable the prep

280 Here in a designer surface plasmon platform consisting of tunable

281 and rotational Doppler effects from several designer surfaces.

282 C and at atmospheric pressure in an aqueous designer surfactant medium.

283 ient temperatures using small amounts of the designer surfactant TPGS-750-M, thereby eliminating the

284 studies have shown that aqueous solutions of designer surfactants enable a wide variety of valuable t

285 at can be programmed to synthesize different designer syngas ratios.

286 This work sets the stage for completion of a designer, synthetic eukaryotic genome.

287 tput, and open up the possibilities of using designer-tailored pulses for controlling molecular dynam

288 atible strains or by engineering a synthetic designer TAL effector to boost SWEET gene expression.

289 Activation of GhSWEET10 by designer TAL effectors (dTALEs) restores virulence of Xc

290 Designer TALEs (dTALEs) for the bHLH transcription facto

291 gnatures characteristic to different genetic designers, termed 'genetic engineering attribution', wou

292 open source interactive microfluidic system designer that readily supports state of the art design a

293 We achieve this by fusing T1(TACE), a designer TIMP-1 with superb affinities for MT1-MMP and T

294 It behooves providers and trial designers to consider these in future evaluations of new

295 of detail is a step forward that now allows designers to inspect and refine their designs with base-

296 gs show that gold mesoflowers may serve as a designer toolkit for engineering colloidal interaction a

297 duced a kinetically sensitive dual-frequency designer waveform into the Fourier-transformed large-amp

298 in the use of de novo metabolic pathways and designer whole-cells for small molecule synthesis, the i

299 Cyclic peptides have long tantalized drug designers with their potential ability to combine the be

300 erially and in parallel through the workflow designer, with multiple, customizable reference database