ライフサイエンスコーパス: desumoylation

1 ype calcium channels, results in rapid FOXP1 deSUMOylation.

2 -phase process is involved in Mre11 and Nbs1 desumoylation.

3 are decreased by SUMOylation and enhanced by deSUMOylation.

4 ost closely related to enzymes that catalyze desumoylation.

5 LESS-RELATED1 (TPR1) and contributes to TPR1 deSUMOylation.

6 ing a direct requirement of OsOTS1-dependent deSUMOylation activity in rice nuclei for salt tolerance

7 of c-Jun but is critically dependent on the desumoylation activity of SENP1.

8 yelocytic leukemia but is independent of the desumoylation activity of SuPr-1.

9 temperature elevation, indicating that BRI1 deSUMOylation acts as a safety mechanism necessary to ke

10 CaN-catalyzed dephosphorylation promotes the desumoylation and acetylation of MEF2D, increasing its t

11 Our study suggests that TNFalpha-induced desumoylation and cytoplasmic translocation of HIPK1 are

12 We conclude that desumoylation and subsequent inhibition of RNA polymeras

13 Interestingly, I/R stress leads to desumoylation and translocation of nuclear SIRT1 into th

14 hway homeostasis by promoting target protein desumoylation and/or degradation.

15 mes is required for MEF2D dephosphorylation, desumoylation, and acetylation in C2C12 cells.

16 SUMOylation and deSUMOylation are dynamic mechanisms regulating a spectr

17 physiologic consequences of SUMOylation and deSUMOylation are not fully understood.

18 Altogether, our work establishes BRI1 deSUMOylation as a molecular crosstalk mechanism between

19 nt phosphorylation of LXRs, leading to their deSUMOylation by the SUMO protease SENP3 and release fro

20 -induced-sumoylation stabilizes Smo, whereas desumoylation by Ulp1 destabilizes Smo in a phosphorylat

21 s, perhaps counterintuitively, Ulp1-mediated desumoylation can promote SUMO modification by stabilizi

22 ingly, we showed that TNFalpha induced HIPK1 desumoylation concomitant with a translocation from nucl

23 Desumoylation did not affect the catalytic activity of P

24 Collectively, our data reveal that deSUMOylation differentially primes cells for responding

25 Da (Sp110) is SUMO1-modified and undergoes a deSUMOylation-driven release from the PML-NB in the pres

26 highlighting the biological requirement for deSUMOylation dynamics.

27 802-815) demonstrate how a desumoylation enzyme is targeted to the nucleolus for re

28 Furthermore, we demonstrate that the desumoylation enzyme SuPr-1 can be modified by SUMO-1-VS

29 es Smo sumoylation by dissociating it from a desumoylation enzyme Ulp1.

30 RING domain mutants or by coexpression of a desumoylation enzyme.

31 specific protease 1 (SENP1) and 2 may act as deSUMOylation enzymes for MTA1.

32 Disruption of the sumoylation/desumoylation equilibrium is associated with several dis

33 cate a critical role of balanced SUMOylation/deSUMOylation for proper cardiac development, metabolism

34 The physiological importance of desumoylation has been revealed by mutations in either g

35 ) modification of proteins (SUMOylation) and deSUMOylation have emerged as important regulatory mecha

36 to quantitatively image p53 sumoylation and desumoylation in cells and living mice.

37 we identify different mechanistic roles for deSUMOylation in homologous recombination (HR) and nonho

38 identify a critical role for SENP1-mediated deSUMOylation in promoting Pin1 function during tumorige

39 are modified by SUMO; however, the effect of desumoylation in regulating nuclear receptor function ha

40 Preventing deSUMOylation in Schizosaccharomyces pombe results in sl

41 view the current knowledge about SUMOylation/deSUMOylation in the heart and provide an integrated pic

42 es provide insights on the potential role of desumoylation in the regulation of nuclear receptor acti

43 However, our understanding of a role for deSUMOylation in this process is limited.

44 A key target for SENP3-mediated deSUMOylation is the GTPase Drp1, which plays a major ro

45 activates SUMO-PKD2, not PKD2, channels, as desumoylation leads to loss of I(Na) activation in myocy

46 In parallel with IRF8 deSUMOylation, macrophage activation led to the inductio

47 e the possibility that NPC-localized protein desumoylation may be a key regulatory event preventing i

48 t of either cellular sumoylation or cellular desumoylation mechanisms inhibits cell growth in the abs

49 Whereas the K830 deSUMOylation mutation of LATS1 found in the human metas

50 endent transcription is not mediated through desumoylation of AR, but rather through its ability to d

51 ss, Arabidopsis plants arrest growth through deSUMOylation of BZR1 in the cytoplasm by promoting the

52 DeSUMOylation of Drp1 by the enzyme SENP3 promotes cell

53 r following reoxygenation after OGD allowing deSUMOylation of Drp1, which facilitates Drp1 localizati

54 lly, inflammation-induced SENP1 promotes the deSUMOylation of GATA2 and IkappaBalpha in endothelial c

55 regulate AR-dependent transcription through desumoylation of HDAC1.

56 h age-related changes in SUMOylation and the deSUMOylation of key target proteins in the spindle appa

57 cogenesis, our studies support the idea that deSUMOylation of Maf1 and induction of its gene targets

58 We found that regulated deSUMOylation of MDC1 prevents excessive SUMOylation and

59 uggesting that Ad regulates paralog-specific desumoylation of Nbs1.

60 otypes thought to be caused by inappropriate desumoylation of nucleoplasmic targets that are normally

61 SENP1-mediated deSUMOylation of PKC is involved in the kainate-induced

62 entrin-specific peptidase 1 (SENP1)-mediated deSUMOylation of PKC, indicating that the crosstalk betw

63 We propose that deSUMOylation of RIPK1 by SENP1 provides a pathophysiolo

64 all types of stress tested here resulted in desumoylation of subunits of RNA polymerase III, which c

65 apamycin complex 1 (TORC1), results in rapid desumoylation of these proteins, which is reflected by l

66 Importantly, VdUlpB mediates deSUMOylation of VdEno facilitates its cytoplasmic distr

67 (conjugating enzyme; E2), and ULP1 and ULP2 (desumoylation peptidases) are all doxorubicin resistant,

68 These results demonstrate that deSUMOylation plays a critical role in prostate pathogen

69 MEL-18 facilitated the deSUMOylation process by inhibiting BMI-1/RING1B-mediate

70 Thus, Drp1 deSUMOylation promotes cell death by enhancing Mff-media

71 However, how deSUMOylation recruits Drp1 to the MOM is unknown.

72 protein SUMOylation, and that inhibition of deSUMOylation reduces GSIS.

73 Here we show that deSUMOylation selectively promotes Drp1 binding to the M

74 hogenic mechanism of VdUlpB-mediated enolase deSUMOylation, which fortifies glycolytic pathway for gr

75 orylation of Bcl11b was coupled to its rapid desumoylation, which was followed by a subsequent cycle

76 Increasing deSUMOylation with sentrin/SUMO-specific protease SENP1