ライフサイエンスコーパス: deuterostome

1 es designated the Nephrozoa (protostomes and deuterostomes).

2 locentrotus purpuratus, a basal invertebrate deuterostome.

3 f regeneration-specific gene expression in a deuterostome.

4 ic protostome or from a more closely related deuterostome.

5 the conservation of local gene order across deuterostome.

6 in the sea urchin embryo, an early branching deuterostome.

7 conceived for sea urchins, nor for any other deuterostome.

8 t prior to the divergence of protostomes and deuterostomes.

9 atory interaction as an ancestral feature of deuterostomes.

10 asal mode of germ line determination amongst deuterostomes.

11 urchin cytoskeletal genes to those of other deuterostomes.

12 ess sensing and response mechanisms in early deuterostomes.

13 own hemichordates, and is among the earliest deuterostomes.

14 great insights into the basal properties of deuterostomes.

15 luable models to clarify neural evolution in deuterostomes.

16 of a Wnt-A ortholog thought to be absent in deuterostomes.

17 rged during the evolution of protostomes and deuterostomes.

18 he adults acquire a body plan unique for the deuterostomes.

19 ates and between invertebrate and vertebrate deuterostomes.

20 ellular protons and are considered unique to deuterostomes.

21 suggest its phylogenetic position within the deuterostomes.

22 present in non-moulting lophotrochozoans and deuterostomes.

23 e to those found in spiralians, nematodes or deuterostomes.

24 on even before divergence of protostomes and deuterostomes.

25 derm differentiation in both protostomes and deuterostomes.

26 genomic blocks between the 2 millipedes and deuterostomes.

27 ess of maximal indirect development in basal deuterostomes.

28 e sister group to the echinoderms within the deuterostomes.

29 study enteric nervous system regeneration in deuterostomes.

30 utionary history of Brachyury utilization in deuterostomes.

31 el system for studying these interactions in deuterostomes.

32 re of appendage formation in protostomes and deuterostomes.

33 ch have variously been regarded as proto- or deuterostomes.

34 ngths-coincide with support for monophyletic deuterostomes.

35 ing the molecular basis of development among deuterostomes.

36 f behavioral systems in both protostomes and deuterostomes.

37 common bilaterian ancestor to the origin of deuterostomes.

38 ed to the common ancestor of protostomes and deuterostomes.

39 he development of multiple structures across deuterostomes.

40 e very inception of pharyngeal pores in stem deuterostomes.

41 major protostome lineages and non-vertebrate deuterostomes.

42 nderlying patterning similarities with other deuterostomes.

43 to the evolution of diverse body plans among deuterostomes.

44 tratigraphically are amongst the earliest of deuterostomes.

45 elomorpha as an early branching taxon in the deuterostomes.

46 he apparent absence of TCAM1 in invertebrate deuterostomes.

47 e early anterior neuroectoderm (ANE) in many deuterostomes.

48 They were then considered deuterostomes.

49 Together, these three phyla comprise the deuterostomes.

50 s with diverging orientations in all studied deuterostomes.

51 GlyT1- and GlyT2-like genes in invertebrate deuterostomes.

52 stoma floridae, elucidating pNP evolution in deuterostomes.

53 tructure and function across protostomes and deuterostomes.

54 and mesoderm fates is not well understood in deuterostomes.

55 s, 10 non-mammal vertebrates, 3 invertebrate deuterostomes, 13 insects, 6 worms and a yeast.

56 s, 13 non-mammal vertebrates, 3 invertebrate deuterostomes, 13 insects, 6 worms, yeast and sea hare.

57 establishment of anteroposterior polarity in deuterostomes(3-5) and other bilaterians(6-8) using RNA

58 ared after the divergence of protostomes and deuterostomes 450-600 million years ago, while NCBD was

59 clade that appears related to the protostome/deuterostome A clade of fibrillar collagens.

60 ips suggest that amphioxus shares with other deuterostomes a common mechanism for patterning along th

61 data indicate that in an ancestor of extant deuterostomes a remarkable and unique event in the evolu

62 Among extant deuterostomes, a skeleton in which each plate has the cr

63 indings, together with the identification of deuterostome achatin and luqin and protostome opioid pNP

64 Based on this deuterostome ALG complement, we deduced chromosomal rear

65 These deuterostome ALGs in turn match previously inferred bila

66 the last common ancestor of protostomes and deuterostomes already possessed an ultrafiltration-based

67 last common ancestor of the protostomes and deuterostomes, an animal from which >98% of all describe

68 ventional view of the last common protostome-deuterostome ancestor (PDA) as a complex organism that p

69 ated myocytes were present in the protostome-deuterostome ancestor and that smooth myocytes later co-

70 c evidence for a well-ordered complex in the deuterostome ancestor for the hox1-hox9/10 region, with

71 We propose that the deuterostome ancestor may have had a diffuse nervous sys

72 of the early neurogenic domain in the common deuterostome ancestor of echinoderms and vertebrates.

73 lly in patterning pharyngeal structures in a deuterostome ancestor of vertebrates.

74 Here, we show that the deuterostome ancestor possessed a molecular toolkit homo

75 were probably inherited from the last common deuterostome ancestor, and then explore evolutionary tra

76 zed, or a noncentralized nervous system of a deuterostome ancestor.

77 go, while NCBD was present in the protostome/deuterostome ancestor.

78 ikingly different phyla from the last common deuterostome ancestor.

79 d part of the mucociliary sole in protostome-deuterostome ancestors and diversified independently int

80 fic mesenchymal-to-epithelial transitions in deuterostome ancestors.

81 her deuterostomes and can be derived from 24 deuterostome ancestral linkage groups (ALGs).

82 urchin identifies conserved features of the deuterostome ancestral pathway, including positive feedb

83 s were probably overlapping in the ancestral deuterostome and came to abut at the MHB early in the ch

84 en used to gain insights into the origins of deuterostome and chordate body plans.

85 rdate neuroanatomy for testing hypotheses on deuterostome and chordate evolution, adult hemichordate

86 Whereas the genomes of plants and deuterostome and chordate invertebrates harbor large ars

87 Single homologs are present in basal deuterostome and insect genomes, including Drosophila, a

88 ), is found in sponges, cnidarians, and both deuterostome and protostome groups but does not appear t

89 the sea urchin's role as a model system for deuterostome and, by extension, chordate development.

90 me-scale macrosynteny when compared to other deuterostomes and can be derived from 24 deuterostome an

91 examines larval and adult body plans in the deuterostomes and discusses two distinct ways of evolvin

92 plying their origin before the divergence of deuterostomes and ecdysozoans.

93 Echinoderms are among the most primitive deuterostomes and have been used as model organisms to u

94 rian fossils have been suggested to be early deuterostomes and hence could help elucidate ancestral c

95 previously been proposed for protostomes vs deuterostomes and instead suggest that various features

96 fic gene novelties, including genes found in deuterostomes and marine microbes, but not other animals

97 r retinoic acid (RA) probably evolved in the deuterostomes and may be chordate-specific.

98 Deuterostomes and protostomes also show large genome nov

99 Thus, the divergence of deuterostomes and protostomes may have been accompanied

100 Deuterostomes and protostomes split about 670 million ye

101 egrins originated prior to the divergence of deuterostomes and protostomes.

102 he CK lineage, well before the divergence of deuterostomes and protostomes.

103 vertebrate genes prior to the divergence of deuterostomes and protostomes.

104 vertebrate genes prior to the divergence of deuterostomes and protostomes: in one case there was sig

105 he stage of highest molecular resemblance in deuterostomes and that much of the molecular basis of de

106 to the nature of the last common ancestor of deuterostomes and that of bilaterians.

107 e Mab-5 genes of nematodes and Hox6 genes of deuterostomes and would therefore have been present in t

108 brain as it emerged independently in certain deuterostomes and xenacoelomorphs.

109 e two pathways appears to be conserved among deuterostomes, and in the case of Notch at least, displa

110 e foremost morphological innovation of early deuterostomes, and is probably central to their filter-f

111 gin before the divergence of protostomes and deuterostomes, and may ancestrally have been involved in

112 letogenesis in the brittle star, as in other deuterostomes, and provide evidence for the re-deploymen

113 nt capacity in the common ancestor of living deuterostomes, and that their specific role in the adapt

114 kowalevskii represent the derived state for deuterostomes, and we argue that functional evolution ac

115 e embryos reveal striking similarities among deuterostome ANE regulatory networks and the molecular m

116 Deuterostome animals exhibit widely divergent body plans

117 yzed the NAD kinases (NADKs) of a variety of deuterostome animals, finding two conserved internal dom

118 F cycling and Ca(2+) signaling in oocytes of deuterostome animals.

119 Deuterostomes are a monophyletic group of animals that i

120 Deuterostomes are a morphologically disparate clade, enc

121 Deuterostomes are characterized by some of the most wide

122 ionships between invertebrate and vertebrate deuterostomes are clearly important for understanding ou

123 Although deuterostomes are considered monophyletic, the inter-rel

124 Deuterostomes are one major group of bilaterians compose

125 lts support the strength of this nonchordate deuterostome as a pivotal developmental and evolutionary

126 within the Class II, Spfkh1 groups with the deuterostomes as opposed to the protostomes.

127 ring relationship that also later serves, in deuterostomes, as the anatomical site of the anus.

128 body-axis formation and organization across deuterostomes, at stages before morphological difference

129 lex, ancient genetic regulatory scaffold for deuterostome body patterning that degenerated in amphiox

130 The diversity of deuterostome body plans has made it challenging to recon

131 In vertebrates (deuterostomes), brain patterning depends on signals from

132 A very short, or non-existent, deuterostome branch has implications for interpreting pu

133 sentative species of both the protostome and deuterostome branches of the metazoan phylogenetic tree.

134 and 530 Ma evidently includes the protostome-deuterostome branching, diversification of independent h

135 elopment and gastrulation are similar in all deuterostomes, but, in chordates, the anterior-posterior

136 Here we show that protostome and deuterostome cartilage share structural and chemical pro

137 raction, structure, and functionality of all deuterostome cells and have major functions in cellular

138 support of pharyngeal gill slits as a shared deuterostome character, provide the foundation for the e

139 The posterior Hox group expanded in the deuterostome clade and patterns caudal and distal struct

140 ither at the base of the bilateria or of the deuterostome clade, we report the ligand binding propert

141 and echinoderms, which together make up the deuterostome clade.

142 ata acoelomorphs might instead be degenerate deuterostomes closely related to Xenoturbella, muddying

143 to infer the chromosomal architecture of the deuterostome common ancestor and delineate lineage-speci

144 The branch between bilaterian and deuterostome common ancestors is, at best, very short, s

145 ea urchin representatives thus expanding the deuterostome complement.

146 Deuterostomes comprise vertebrates, the related inverteb

147 stent with the "ecdysozoa" hypothesis) or to deuterostomes (consistent with "coelomata").

148 tic analysis, using a revised, comprehensive deuterostome dataset, and establish a chordate stem line

149 omes and that much of the molecular basis of deuterostome development was probably present in the bil

150 e beginning to yield important insights into deuterostome developmental mechanisms.

151 Deuterostome Dicer-1 ancestor, while exhibiting lower ds

152 This larva, typically for the ancestral deuterostome dipleurula larval type that it represents,

153 family originated before the protostomes and deuterostomes diverged, over 525 million years ago.

154 vertebrate divergence, after the protostome-deuterostome divergence but before the amniote-amphibian

155 ted to chordates and postdate the protostome/deuterostome divergence, they must have evolved from bil

156 protostomes (e.g., flies and flatworms) and deuterostomes (e.g., humans and sea urchins) possess spe

157 g., mollusks, annelids, and arthropods) and "deuterostomes" (e.g., echinoderms and chordates) display

158 oans, bilaterians, chordate and non-chordate deuterostomes, ecdysozoan and lophotrochozoan protostome

159 tified in all three groups of the Bilateria (deuterostomes, ecdysozoans, and lophotrochozoans).

160 opods, annelids, and mollusks) diverged from deuterostomes (echinoderms and chordates) about 670 mill

161 appears to be lacking in more early-diverged deuterostomes (echinoderms, hemichordates), it is uncert

162 ranscription factors with conserved roles in deuterostome ectodermal anteroposterior (AP) patterning

163 mes suggest that patterning of the ancestral deuterostome embryo along its anterior-posterior axis du

164 ening between the gut and the outside of the deuterostome embryo breaks through at the extreme anteri

165 hibition of cWnt signaling in cleavage-stage deuterostome embryos for normal AP patterning is less we

166 is present after fertilization whereas most deuterostome embryos show minimal polarity during the ea

167 a critical event in the early development of deuterostome embryos.

168 uggesting a common origin for protostome and deuterostome epidermal sensory cells in the ancestral bi

169 divergence of this novel gene family during deuterostome evolution and provide further evidence that

170 ly these findings suggest that a key step in deuterostome evolution was the development of lateral op

171 ave been maintained throughout the course of deuterostome evolution.

172 cells may have evolved during the course of deuterostome evolution.

173 nciples underlie TAD compartmentalization in deuterostome evolution.

174 of the notochord represented a milestone in Deuterostome evolution.

175 ships between them might have changed during deuterostome evolution.

176 amphioxus and vertebrates or even earlier in deuterostome evolution.

177 rees, GlyT2-like sequences from invertebrate deuterostomes form a monophyletic subclade with vertebra

178 h has implications for interpreting putative deuterostome fossils and for reconstructing the bilateri

179 Data from diverse deuterostomes (frog, fish, mouse, and amphioxus) and fro

180 Analysis of the basic deuterostome genetic complement supports the sea urchin'

181 ne expansion in the urchin relative to other deuterostome genomes, whereas the stress sensor gene fam

182 A deuterostome Grl from the sea urchin Strongylocentrotus

183 rst evidence for a nodal orthologue in a non-deuterostome group.

184 To study the relationships among all deuterostome groups, we have assembled an alignment of m

185 Our findings suggest that the ancestral deuterostome had a population of biomineral-forming mese

186 that the common ancestor of protostomes and deuterostomes had a minimum complement of 14 Fox genes.

187 the last common ancestor of protostomes and deuterostomes had a prototype of the brains present in m

188 Several invertebrate deuterostomes have two paralogous glycine carrier genes,

189 bination, also including an SPS, upstream of deuterostome Hes repressor genes, which are also Notch t

190 ost of the components of both protostome and deuterostome Hh signaling pathways are present in anthoz

191 In the sea urchin, a basal deuterostome, Hh signaling is shown to participate in or

192 ported pharyngeal openings in support of the deuterostome hypothesis(6) are shown to be taphonomic ar

193 rgence of globin families in protostomes and deuterostomes (i.e. convergent evolution).

194 it from the common ancestor of copepods and deuterostomes, i.e. the ancestral bilaterians.

195 types of genes expected to be used in lower deuterostome immune functions.

196 ily are known to function in protostomes and deuterostomes in the specification of mesodermal fates.

197 ancestor of animals and is conserved in all deuterostomes, in contrast to the alternative L-ascorbat

198 Deuterostomes include the group we belong to (vertebrate

199 s of nodal have also been described in other deuterostomes, including ascidians and sea urchins, but

200 PF/PrRP/sNPF-related signalling systems in a deuterostome invertebrate phylum - the Echinodermata.

201 of the biology and evolution of nonchordate deuterostomes, invertebrate chordates, and vertebrates.

202 of adhesion proteins between protostome and deuterostome invertebrates and between invertebrate and

203 l network that regulates axial patterning in deuterostomes is evolutionarily conserved.

204 knowledge of TLR pathway evolution in other deuterostomes is limited.

205 however, showing that the branch leading to deuterostomes is very short and may be influenced by sys

206 adult forms and confirm the hypothesis that deuterostome larvae are "swimming heads" [3].

207 a that the bilaterian ancestor may have been deuterostome-like.

208 lly characterized, is present throughout the deuterostome lineage but is a pseudogene in humans and o

209 drate modification of glycoconjugates in the deuterostome lineage of animals.

210 ology of the innate immune system within the deuterostome lineage of animals.

211 glec expression may be limited to animals of deuterostome lineage, coincident with the appearance of

212 or the evolution of these subclasses in the deuterostome lineage.

213 ant cell-surface molecules of animals in the deuterostome lineage.

214 ge, which includes starfish to humans in the deuterostome lineage.

215 tructure identifiable in both protostome and deuterostome lineages and that the duplication seen in v

216 as also found to be present across all major deuterostome lineages despite the apparent absence of TC

217 d Deuterostomia, and further loss in several deuterostome lineages.

218 ic changes that drove the diversification of deuterostome lineages.

219 erged before the bifurcation of nematode and deuterostome lines.

220 at FGF signaling played an ancestral role in deuterostome mesoderm formation.

221 mportant differences between protostomes and deuterostomes mitochondrial proteins: (1) ND5, and with

222 t sea star larvae can provide a valuable new deuterostome model for the study of regeneration genetic

223 lying these findings also to murine or other deuterostome models.

224 in their amino acid composition-we find that deuterostome monophyly is strongly supported.

225 ropoda and Nemertea but are unable to reject deuterostome monophyly.

226 etic studies have not consistently supported deuterostome monophyly.

227 nstrates significant conservation throughout deuterostomes; no sequence with significant identity to

228 hytus coronarius was interpreted as an early deuterostome on the basis of purported pharyngeal openin

229 Among deuterostomes, only echinoderms and vertebrates produce

230 no apparent homologues in other invertebrate deuterostomes or vertebrates.

231 lateria (= Nephrozoa, namely protostomes and deuterostomes) or is a clade inside Deuterostomia.

232 NCBD and CID, likely emerged in an ancestral deuterostome organism as a low-affinity interaction that

233 enoturbellida, bringing the number of living deuterostome phyla to four.

234 to predate the divergence of protostome and deuterostome phyla.

235 ior-posterior expression patterns illuminate deuterostome phylogenetic relationships and the evolutio

236 dae), an invertebrate that diverged early in deuterostome phylogeny.

237 ordates that occupy an important position in deuterostome phylogeny.

238 Hemichordates are a deuterostome phylum, the sister group to echinoderms, an

239 fect in cytosolic extracts from invertebrate deuterostomes (phylum Echinodermata).

240 ambrian ancestor of most protostomes and the deuterostomes possessed elements of the genetic machiner

241 If so, the protostomes and deuterostomes probably shared a common segmented ancesto

242 c plasticity evolved gradually, yet the last deuterostome-protostome common ancestor already possesse

243 es, the proportion of duplications after the deuterostome-protostome split was constant across famili

244 oturbella and that Xenoturbella is in fact a deuterostome related to hemichordates and echinoderms.

245 controversial and the nature of the original deuterostome remains idealized.

246 important groups, arthropods, nematodes, and deuterostomes, remains unresolved.

247 Egg activation at fertilization in deuterostomes requires a rise in intracellular Ca(2+), w

248 the ancestral body plans of major clades of deuterostomes, revealing that key traits of extant forms

249 bly, the anterior neuroectoderm (ANE) of the deuterostome sea urchin embryo expresses many of the sam

250 ior (AP) specification and patterning of the deuterostome sea urchin embryo.

251 nome level, as this is the first nonchordate deuterostome sequence.

252 ertebrate MN1 gene evolved from an ancestral deuterostome sequence.

253 hins is similar to that found in other basal deuterostomes, signal-responsive initiator caspase subfa

254 ed anterior neuroectoderm development across deuterostome species, using available single-cell datase

255 king in arthropod or nematode genomes may be deuterostome-specific (subclasses I, J1, J2, L1, M and Q

256 Comparative analysis reveals numerous deuterostome-specific gene novelties, including genes fo

257 Notably, hemichordates possess a deuterostome-specific genomic cluster of four ordered tr

258 y expressed bmp4 and admp genes represents a deuterostome-specific innovation.

259 invertebrates although there are significant deuterostome-specific innovations and some interesting f

260 We also provide evidence that the deuterostome-specific pharyngeal gene cluster was establ

261 mostly in triploblasts before the protostome-deuterostome split, whereas few subfamilies were lost in

262 that remarkably is linked to the protostome-deuterostome split.

263 These observations and results in other deuterostomes suggest that Axin plays a crucial conserve

264 Comparisons of Amphioxus with other deuterostomes suggest that patterning of the ancestral d

265 ave been demonstrated and exemplified by the deuterostome tachykinin signaling system, although the r

266 alyzing genomes and transcriptomes across 37 deuterostome taxa, we shed light on the evolution and di

267 r development of anterior structures in many deuterostome taxa.

268 , have significantly lower hydrophobicity in deuterostomes than in proterostomes; (2) the C-terminal

269 ovel family of neuropeptides in invertebrate deuterostomes that are derived from neurophysin-containi

270 nalling for the first time in a non-chordate deuterostome - the starfish Asterias rubens (phylum Echi

271 In the sea urchin, a prototypic deuterostome, the ectoderm-endoderm boundary is establis

272 chozoan shares with an indirectly developing deuterostome, the sea urchin, a common mode of Hox compl

273 In deuterostomes, the ancestral Wirin evolved into the IgLO

274 Among the earliest deuterostomes, the echinoderms are an evolutionary impor

275 The early history of deuterostomes, the group composed of the chordates, echi

276 RH-type and CRZ-type signalling systems in a deuterostome-the echinoderm (starfish) Asterias rubens.

277 lling a significant morphological gap in the deuterostome tree of life.

278 characteristics with vertebrates, including deuterostome type development.

279 and mechanisms of mesoderm specification in deuterostomes unclear.

280 roides genome content with distantly related deuterostomes (urchins, sea squirts, and humans) suggest

281 Thus, indirect-developing deuterostomes use BMP signaling in DV and neural pattern

282 ndamental body plan within a basal phylum of deuterostomes was enteropneust-like.

283 investigate this process in an invertebrate deuterostome, we defined Axin function in early sea urch

284 to the mouth and anus of the protostomes and deuterostomes, we studied the expression of genes involv

285 y complex members of astacin-type enzymes in deuterostomes, which can add supporting data to corrobor

286 o argue that the foreguts of protostomes and deuterostomes, which have traditionally been assigned to

287 f larger extra-membrane hydrophilic loops in deuterostomes with respect to protostomes; (3) substitut

288 ulacral ectoderm shows similarity with other deuterostomes, with the midline of each ray representing