ライフサイエンスコーパス: devaluation

1 the current value of specific rewards after devaluation.

2 ained goal-directed and sensitive to outcome devaluation.

3 , and given overtraining followed by outcome devaluation.

4 a habit-based system no longer sensitive to devaluation.

5 in object choices in response to reinforcer devaluation.

6 , cocaine seeking was insensitive to outcome devaluation.

7 ediators of adaptive responses to reinforcer devaluation.

8 s in their activity as a function of outcome devaluation.

9 cient to impair the expression of reinforcer devaluation.

10 ptibility of oral cocaine seeking to outcome devaluation.

11 ation of the outcome which is insensitive to devaluation.

12 sensitivity of that responding to reinforcer devaluation.

13 detectable effect on sensitivity to outcome devaluation.

14 ody (MB) neurons prevents premature stimulus devaluation.

15 ircuitry mediating the effects of reinforcer devaluation.

16 ived CS-saline or LiCl alone during mediated devaluation.

17 ubgenual cingulate appear to be sensitive to devaluation.

18 formation generates insensitivity to reward devaluation.

19 cocaine-seeking behavior following mediated devaluation.

20 ecurity, political instability, and currency devaluation.

21 upt cocaine-seeking behaviors using mediated devaluation.

22 e P3b, from 550-700 ms) sensitive to outcome devaluation.

23 me values to guide behavior after reinforcer devaluation.

24 the progressive hold-down task, and outcome devaluation.

25 ons that coactivate with shame-fail to track devaluation.

26 better the rats suppressed responding after devaluation.

27 demonstrating evidence of outcome-selective devaluation.

28 ion of the IC and NAc core disrupted outcome devaluation.

29 lateral NAc core abolished outcome-selective devaluation.

30 ertraining, which were identified using goal-devaluation.

31 emonstrated a lack of sensitivity to outcome devaluation.

32 bust effects on behavior until after outcome devaluation.

33 ly in the IC before test abolished selective devaluation.

34 reduction was correlated with choices after devaluation.

35 lished outcome devaluation when given before devaluation.

36 ior training to direct performance following devaluation.

37 inactivation surprisingly led to generalized devaluation, a result that is inconsistent with a comple

38 associations is abolished following sucrose devaluation, a signature of identity-based learning.

39 d controls for their responses to reinforcer devaluation, a task that assesses the monkeys' abilities

40 contrast, responding that is insensitive to devaluation after 8 weeks of training becomes sensitive

41 ns of the BLA will interfere with reinforcer devaluation after appetitive Pavlovian or instrumental c

42 ter 8 weeks of training becomes sensitive to devaluation after inactivation of the DLS but is unaffec

43 tal cortex (OFC) in a task assessing outcome devaluation after initial instrumental training and afte

44 ed sham lesioned rats insensitive to outcome devaluation, an effect that was also found in rats given

45 The subsequent outcome devaluation and 'slip-of-action' tests allowed evaluatio

46 hese two alternatives using outcome-specific devaluation and a high-potency chemogenetic approach.

47 se rats showed greater sensitivity to reward devaluation and also self-administered more heroin, high

48 rat BLA to specific components of reinforcer devaluation and are the first to show impairment in rein

49 outcome, before their sensitivity to outcome devaluation and degradation of the instrumental continge

50 be reinforced, though sensitivity to outcome devaluation and extinction were intact.

51 varies with levels of performance on reward devaluation and object reversal tasks, volumes of areas

52 ion and outcome, as well as sensory-specific devaluation and omission tests, demonstrate that these l

53 e relationship between the outcome-selective devaluation and reinstatement effects and found evidence

54 directed, being highly sensitive to outcome devaluation and reversal of the action-outcome contingen

55 ongitudinal recordings revealed that this SD devaluation and subsequent shift toward HFD consumption

56 Ar activation unilaterally in the BLA before devaluation and then contralaterally in the IC before te

57 rumental behavior insensitive to the outcome devaluation (and thus habitual), whereas hydrocortisone

58 s decreased after acquisition for one group (devaluation) and held constant for another group (contro

59 f specific rewards in the OFC are updated by devaluation, and how functional connections to vmPFC ref

60 t value of the outcome which is sensitive to devaluation, and one that learns about the spatial local

61 extinction, contingency degradation, outcome devaluation, and Pavlovian-to-instrumental transfer (n =

62 satiety, Pavlovian conditioning, reinforcer devaluation, and simultaneous visual discrimination.

63 Tests of specific satiety induced outcome devaluation, and tests of PIT revealed that, although th

64 posterior OFC were modulated after selective devaluation, and that connectivity between this region a

65 After satiety- or sickness-induced devaluation, ARC(AGRP) neurons drove calorie-specific fe

66 ion in the others, suggesting that shame and devaluation are informed by a common species-wide logic

67 d the effects of sensory-specific reinforcer devaluation as a way to probe each monkey's use of goal-

68 nitial training using sensitivity to outcome devaluation as an assay of goal-directed performance.

69 arning, delayed alternation, extinction, and devaluation as well as more recent findings showing the

70 eting activity pattern insensitive to reward devaluation but sensitive to running automaticity.

71 the OFC did not affect instrumental outcome devaluation, but abolished the transfer effect.

72 in training is goal-directed and reduced by devaluation, but after 8 weeks of daily operant training

73 Critically, reward devaluation by both cognitive and physical effort was su

74 ter pavlovian light-food pairings but before devaluation by food-toxin pairings, Ostlund and Balleine

75 t in RED), and dietary manipulations (reward devaluation by pre-feeding) were consistent with the pre

76 ar reductions of licking responses following devaluation by satiety in both early and late sessions.

77 Sensitivity to devaluation by specific satiety was then assessed.

78 In the win-shift task, devaluation caused rats to reject the reinforcer, yet th

79 rned and control behavior, and otherwise the devaluation circuit does not require MD.

80 rther suggest that MD is a necessary part of devaluation circuits only in cases in which previous ass

81 After conditioning, rats in a devaluation condition were given access to sucrose in th

82 regions on instrumental performance, outcome devaluation, degradation of the instrumental contingency

83 Devaluation did not affect latency in overtrained rats b

84 The stigma measure used was the Perceived Devaluation-Discrimination Scale.

85 cue-outcome associations, but before outcome devaluation, disrupted subsequent inference, confirming

86 t BLA is critical for conditioned reinforcer devaluation during the period when the primary reinforce

87 ore-lesioned rats failed to show a selective devaluation effect and reduced responding on both levers

88 n (i.e., MUS infused before satiation), this devaluation effect was blocked.

89 The devaluation effect was not explained by differences in t

90 s that represented the nonsated food reward (devaluation effect).

91 in the ipsilateral group showed a selective devaluation effect, again based on the most recently int

92 tivation of OFC is sufficient to disrupt the devaluation effect, and to document a role for OFC disti

93 ith obtaining the devalued food, called the "devaluation effect," a hallmark of goal-directed behavio

94 BLA lesions impaired this devaluation effect.

95 or agonist muscimol into area 13 blocked the devaluation effect: the monkeys did not reduce their sel

96 gthen effects as well as dimensions where AI-devaluation effects are more pronounced.

97 lesions of the amygdala attenuate reinforcer devaluation effects in monkeys and rats.

98 owed a significant attenuation of reinforcer devaluation effects on each of two separate assessments,

99 h the amygdala and PFo to mediate reinforcer devaluation effects.

100 c amygdala damage interfered with reinforcer devaluation effects.

101 the amygdala exhibited significantly reduced devaluation effects.

102 ate their choice preference following reward devaluation, either when the devalued reward was still d

103 aking choices where the prospective costs of devaluation exceed the benefits, (ii) preventing negativ

104 es by combining a learning task with outcome devaluation, eye-tracking, and functional magnetic reson

105 e the first to show impairment in reinforcer devaluation following transient inactivation in the rat.

106 for lower efforts, and progressively larger devaluations for higher effort-levels (concave shape).

107 rd in a manner opposite to delay, with small devaluations for lower efforts, and progressively larger

108 ibited similar levels of UCS expectancy, the devaluation group had significantly smaller conditional

109 In the test for devaluation, however, OFC rats exhibited no change in co

110 MD lesions caused no devaluation impairment in a multiple-reinforcer Pavlovia

111 imental effects of BLA lesions on reinforcer devaluation in a Pavlovian autoshaping procedure, but no

112 based on current food value using reinforcer devaluation in a test of goal-directed decision-making.

113 seeking and restores sensitivity to outcome devaluation in rats that habitually seek alcohol.

114 with the degree of insensitivity to outcome devaluation in subsequent performance.

115 eover, shame in each country strongly tracks devaluation in the others, suggesting that shame and dev

116 redicted, shame closely tracks the threat of devaluation in the United States (r = .69), India (r = .

117 Amygdala ablation disrupts reinforcer "devaluation" in monkeys.

118 ated the selective satiation-induced change (devaluation) in object preference in probe sessions.

119 ual stimuli, both before and after olfactory devaluation, in a paradigm of appetitive conditioning.

120 ed training, when responding is sensitive to devaluation, inactivation of the DMS greatly attenuates

121 group showed nonselective performance after devaluation indicating that the BLA-DMS pathway is also

122 male (XY) mice became insensitive to outcome devaluation, indicating habitual responding.

123 Attempts to retrieve reward persisted after devaluation, indicating they were habitually performed a

124 id attenuate, however, the impact of outcome devaluation, induced by sensory-specific satiety, on ins

125 id, however, attenuate the impact of outcome devaluation, induced by sensory-specific satiety, on ins

126 To test for both devaluation insensitive and devaluation sensitive Pavlov

127 ncoding state prediction errors appear to be devaluation insensitive.

128 ons about an outcome's spatial location seem devaluation insensitive.

129 reversing the order of these infusions left devaluation intact.

130 but not for the subsequent expression of the devaluation involving its transfer to secondary reinforc

131 mance or on the rats' sensitivity to outcome devaluation; lesion and sham groups both reduced respond

132 The shame-devaluation link is also specific: Sadness and anxiety-e

133 enous cocaine self-administration and reward devaluation methods in rats, the present studies examine

134 ts provide evidence for a mechanism by which devaluation modulates a cognitive map of expected reward

135 nally, we demonstrate that changes in reward devaluation occur early with diet exposure.

136 a hyperbolic model, with the largest reward devaluations occurring at shorter delays.

137 nfusion of protein-synthesis inhibitor after devaluation of a food reward induced by a shift from a f

138 osB should also support greater drug-induced devaluation of a natural reward.

139 ing by focusing on discounting behavior, the devaluation of a reward based on the costs associated wi

140 f 1 beverage resulted in an explicit hedonic devaluation of a similar nonconsumed beverage (P < 0.001

141 itual action strategies in their response to devaluation of A-O contingency.

142 directed and habitual actions in response to devaluation of action-outcome (A-O) contingencies in an

143 pabilities to provide emotional support, the devaluation of AI responses poses a key challenge for ef

144 tem of Drosophila promotes context-dependent devaluation of an egg-laying option that contains sucros

145 Here we implemented selective devaluation of appetizing food odors in combination with

146 x that is strongly connected to OFC prior to devaluation of food odor rewards.

147 p persistently chose those cues, even though devaluation of food odors themselves was unaffected by c

148 fy a neural circuit mechanism that links the devaluation of hedonic foods with obesity.

149 Repetition-induced devaluation of mating results from beta-arrestin-depende

150 Drug addiction is associated with a relative devaluation of natural or socially-valued reinforcers th

151 odel of cue-induced craving and drug-induced devaluation of natural rewards.

152 ioral outcome of processes engaged in timely devaluation of non-reinforced repetitive stimuli, but th

153 t types of justice intuitions: interpersonal devaluation of offenders, judgements of moral wrongness,

154 conditions (sham lesions, saline infusions), devaluation of one food significantly decreased respondi

155 shell- and sham-lesioned rats, post-training devaluation of one of the two outcomes using a specific

156 al responses and food reinforcers but before devaluation of one reinforcer by selective satiation.

157 al studies suggest no difference between the devaluation of real and fictive outcomes, no neuroimagin

158 l behavior in our task is linked to a neural devaluation of reward realized by a prefrontal modulatio

159 e longer durations of slow movements produce devaluation of reward.

160 poral discounting (TD) represents the mental devaluation of rewards that are available after a delay.

161 nonassociative learning that results in the devaluation of sensory inputs that have little informati

162 Here, we report that devaluation of sweetness/sucrose for egg-laying is execu

163 is term avoids the conscious and unconscious devaluation of the "benign" and "non-malignant" descript

164 were impaired in making object choices after devaluation of the associated food reinforcer.

165 Control rats reduced responding following devaluation of the earned outcome as did those with prev

166 tly shown in control rats to be sensitive to devaluation of the expected reward.

167 ) render instrumental actions insensitive to devaluation of the instrumental outcome and degradation

168 Devaluation of the outcome of the drug seeking link (i.e

169 sts with the behavior of control rats; after devaluation of the US a significant decrease occurred in

170 ance, which is reduced by the postdecisional devaluation of unchosen options.

171 This devaluation of women's work in science creates cumulativ

172 nd addiction are associated with an apparent devaluation of, and inattention to, natural rewards.

173 rons spared the suppressive effect of reward devaluation on reward seeking, an assay of goal-directed

174 anisomycin, whether given after the initial devaluation or after a second devaluation session, aboli

175 nto the IC was effective whether made before devaluation or test.

176 s of adolescents remain sensitive to outcome devaluation or to the influence of a pavlovian-condition

177 s predicted by affective signals (reinforcer devaluation) or by visual signals conveying reward conti

178 Here we used a reinforcer devaluation paradigm to investigate the contribution of

179 Here, we have used a reinforcer devaluation paradigm to test this hypothesis.

180 Using a passive devaluation paradigm, we found that exposure to high-fat

181 avior using reversal learning and reinforcer devaluation paradigms.

182 Whereas Pickens et al. found normal devaluation performance in rats when BLA lesions were ma

183 ning BLA lesions disrupted the expression of devaluation performance in rats, using either pavlovian

184 We found that devaluation performance was intact for both groups after

185 airings, Ostlund and Balleine found impaired devaluation performance when BLA lesions were made after

186 MD-lesioned rats were impaired in devaluation performance when switched between Pavlovian

187 ecific information necessary for appropriate devaluation performance, but not in general motivational

188 i, such as a light and a tone, followed by a devaluation phase in which one stimulus is associated wi

189 le to mere exposure to the sucrose US in the devaluation phase.

190 ions left performance insensitive to outcome devaluation, posttraining lesions spared this effect.

191 vation of VTA->NAc circuitry during mediated devaluation prevented the subsequent reduction of cocain

192 Experiments 1A and 1B used an outcome devaluation procedure to assess the effects of the lesio

193 After this devaluation procedure, responding to the CS is assessed

194 ated controls were tested using a reinforcer devaluation procedure.

195 ished through an unconditioned stimulus (US) devaluation procedure.

196 combining Pavlovian conditioning and outcome devaluation procedures while measuring multiple conditio

197 Here we use a variant of outcome devaluation procedures with aversive stimuli to study th

198 conditioned responding after such reinforcer devaluation procedures, animals with BLA lesions made be

199 In reinforcer devaluation procedures, conditioned responding of rats w

200 ange of species, training contingencies, and devaluation procedures.

201 reinforcers, and associative or motivational devaluation procedures.

202 ther conditioned taste aversion or satiation devaluation procedures.

203 m that of BLA for the conditioned reinforcer devaluation process in monkeys.

204 y contrasts with the role of BLA in the same devaluation process.

205 lever press habit evaluated using an outcome devaluation protocol.

206 Subsequently, during mediated devaluation rats received non-contingent presentations o

207 t, relative to appropriate controls, outcome devaluation recruited both the BLA and IC based on activ

208 ations involving social conflict, isolation, devaluation, rejection, and exclusion historically incre

209 chemogenetically inhibited following outcome devaluation, rendering mice incapable of using updated r

210 OFC in representing current value to support devaluation/revaluation sensitive changes in behavior.

211 rrelates for the parallel expression of both devaluation sensitive and insensitive conditioned behavi

212 To test for both devaluation insensitive and devaluation sensitive Pavlovian conditioning in humans,

213 coding predictions about taste identity seem devaluation sensitive while those encoding predictions a

214 A devaluation sensitivity test revealed that both groups c

215 er the initial devaluation or after a second devaluation session, abolished the changes in the value

216 Outcome devaluation showed these runs to be habitual.

217 ibility of the OFC to impairments in outcome devaluation.SIGNIFICANCE STATEMENT This study provides m

218 male (XX) mice remained sensitive to outcome devaluation, signifying goal-directed behavior.

219 However, latent learning and devaluation studies show that behavior also shows hallma

220 Devaluation substantially reduced food consumption on th

221 d subsequent responding following reinforcer devaluation, suggesting modified habit formation.

222 the amygdalectomized monkeys on a reinforcer devaluation task and compared their performance with a g

223 In contrast, the role of the BLA in devaluation task performance once such outcome represent

224 ks, but not when switched from one Pavlovian devaluation task to another Pavlovian devaluation task.

225 The present study used a devaluation task to examine this function.

226 By contrast, on the devaluation task, group OFC x AMY, but not group MFC x A

227 the role of mediodorsal thalamus (MD) in the devaluation task, varying the type of contingencies (Pav

228 h behavior can be isolated in the reinforcer devaluation task, which assesses the ability to infer th

229 lovian devaluation task to another Pavlovian devaluation task.

230 mpairment in a multiple-reinforcer Pavlovian devaluation task.

231 sensitive to amygdala damage, the reinforcer devaluation task.

232 es to modulate instrumental performance in a devaluation task.

233 on the pOFC and aOFC during a 2-day outcome devaluation task.

234 ing training and performance of a reinforcer devaluation task.

235 s impaired in these groups using the outcome-devaluation task.

236 uggest that MD lesions impair performance in devaluation tasks as a result of an inability to switch

237 when switched between Pavlovian and operant devaluation tasks, but not when switched from one Pavlov

238 mage show impaired performance in reinforcer devaluation tasks, in which the value of the food reinfo

239 ala lesions impair performance in reinforcer devaluation tasks, suggesting that the BLA contributes t

240 ehavior, including performance on reinforcer devaluation tasks.

241 The rats were then given an outcome devaluation test (all experiments) and a test of outcome

242 In the subsequent (instructed) outcome devaluation test and in a novel "slips-of-action" test,

243 e DMS enhanced goal-directed behavior by the devaluation test.

244 During a subsequent round of outcome devaluation testing-used to assess the sensitivity of ac

245 to examine the patterns of activation during devaluation testing.

246 ceived muscimol infusions immediately before devaluation testing.

247 ze habit, confirmed the habitual behavior by devaluation tests, and then, during the maze runs (ca. 3

248 ctive Pavlovian-to-instrumental transfer and devaluation tests, we interrogated the function of the b

249 about outcome-specific cues after reinforcer devaluation that are related to behavioral performance a

250 One theory is devaluation-that work done by women is systematically de

251 -for example, fear extinction and reinforcer devaluation--that involve updating representations of va

252 Resistance to outcome devaluation (the defining feature of a habit) was shown

253 psilateral lesioned rats were insensitive to devaluation, the contralateral CeN-DLS lesion impaired h

254 associations to direct performance following devaluation, those in the contralateral group could not,

255 g motivation to eat and reducing food reward devaluation to promote energy intake.

256 immensely from the use of selective outcome devaluation tools, the same cannot be said about aversiv

257 tion, rendering performance sensitive to the devaluation treatment.

258 procedure, but no effect of postconditioning devaluation using a sensory preconditioning procedure.

259 e sensitivity of the lever-press response to devaluation was assessed by prefeeding the rats either E

260 arning, was transiently inactivated, outcome devaluation was effective in decreasing drug seeking ind

261 US devaluation was performed in rats that were over- or und

262 hether the effect of mPFC lesions on outcome devaluation was the result of a more fundamental deficit

263 Devaluation was then accomplished in 1 group by inducing

264 enprodil into the BLA only abolished outcome devaluation when given before devaluation.

265 and (iii) minimizing the adverse effects of devaluation when it occurs.

266 creased behavioral sensitivity to reinforcer devaluation, whereas Bdnf knockdown blocked sensitivity.

267 dictive target stimulus were decreased after devaluation, whereas responses to the nondevalued stimul

268 e reward value in humans, we used reinforcer devaluation while measuring neural activity with functio

269 of a close, specific match between shame and devaluation within and across cultures.

270 is indifference value is sensitive to reward devaluation within each reward domain, and is therefore

271 o change the animal's sensitivity to outcome devaluation without affecting the acquisition or extinct

272 d evidence to directly support the theory of devaluation, yet the results underscore that occupationa