1 Sudden cardiac death (SCD) in the young is
devastating.
2 ncrease in child and maternal deaths will be
devastating.
3 newborns, infection in this age group can be
devastating.
4 Premature, sudden death is
devastating.
5 Brachial plexus injuries are
devastating.
6 Bactrocera (Tetradacus) minax is a major and
devastating agricultural pest in Asian subtropical count
7 highly invasive and known as one of the most
devastating and deadly neoplasms.
8 recipitate aortic dissection or rupture with
devastating and often fatal consequences.
9 Fibrotic disorders are some of the most
devastating and poorly treated conditions in developed n
10 Oil spills can be environmentally
devastating and result in unintended economic and social
11 re efficacious treatment approaches for this
devastating and still uncurable disease.
12 Fulminant viral hepatitis (FVH) is a
devastating and unexplained condition that strikes other
13 , enteropathy, X-linked (IPEX) syndrome is a
devastating autoimmune disease caused by mutations in Fo
14 Systemic lupus erythematosus (SLE) is a
devastating autoimmune disease in which hyperactive T ce
15 stica) cultivars resistant to fire blight, a
devastating bacterial disease caused by Erwinia amylovor
16 The latest Permian mass extinction, the most
devastating biocrisis of the Phanerozoic, has been widel
17 In the
devastating blast fungus Magnaporthe oryzae(1), powerful
18 Retinitis pigmentosa is a
devastating,
blinding disorder that affects 1 in 4000 pe
19 in the gene encoding collagen VII cause the
devastating blistering disease recessive dystrophic epid
20 Patients with a
devastating brain injury and futile medical prognosis in
21 When patients with a
devastating brain injury had a futile prognosis in the E
22 Data regarding definition and prognosis of
devastating brain injury were extracted.
23 review of clinical charts of patients with a
devastating brain injury whose families were approached
24 pants were concerned about "recovery after a
devastating brain injury" (34%), and that "doctors would
25 efore prognosis in the various etiologies of
devastating brain injury, some common themes emerge.
26 included a case scenario of a patient with a
devastating brain injury.
27 have a significant impact on mortality from
devastating brain injury.
28 port for IDD in the case of a patient with a
devastating brain injury.
29 Pulmonary arterial hypertension (PAH) is a
devastating cardiovascular disorder characterized by the
30 tegrity during cerebral ischemia initiates a
devastating cascade of events that eventually leads to n
31 the first month posttransplant is a rare but
devastating cause of early allograft loss after kidney t
32 s known as the epicenter for seeding several
devastating cholera outbreaks across the globe.
33 athic pulmonary fibrosis (IPF) is a rare and
devastating chronic lung disease of unknown etiology.
34 Huanglongbing (HLB) is a
devastating citrus disease worldwide that is putatively
35 pathogen of citrus greening disease that is
devastating citrus industries worldwide.
36 The complexity of human cancer underlies its
devastating clinical consequences.
37 veloping innovative therapies to prevent the
devastating clinical symptoms of infection.
38 ve multifocal leukoencephalopathy (PML) is a
devastating CNS infection caused by JC virus (JCV), a po
39 Moreover, effective therapies to address the
devastating cognitive and behavioral symptoms are also u
40 Ischemic stroke is a
devastating complication affecting children with sickle
41 dy-mediated rejection (AMR) is a potentially
devastating complication and consistently effective trea
42 llograft thrombosis is the most frequent and
devastating complication in the early postrenal transpla
43 Endophthalmitis is a rare but potentially
devastating complication of intravitreal injection.
44 Prosthetic joint infection is a
devastating complication of knee replacement.
45 , parents should be informed on the possible
devastating complications and prompt surgical treatment
46 us infections is essential to preventing the
devastating complications induced by these viruses.
47 Stroke remains one of the most
devastating complications of transcatheter aortic valve
48 additional IOP-lowering surgery or visually
devastating complications) were analyzed.
49 additional IOP-lowering surgery or visually
devastating complications.
50 treatment is often inadequate in preventing
devastating complications.
51 For individuals who sustain
devastating composite tissue loss, vascularized composit
52 Treatment options for this
devastating condition remain extremely limited.
53 Spinal cord ischemia (SCI) is a rare but
devastating condition that can occur in the perioperativ
54 Acute kidney injury (AKI) is a
devastating condition with high morbidity and mortality.
55 STATEMENT Tinnitus, a common and potentially
devastating condition, is the presence of a "phantom" so
56 on-specific prevention and treatment of this
devastating condition.
57 infantile encephalopathies with epilepsy are
devastating conditions mandating an accurate diagnosis t
58 Skeletal muscle wasting is a
devastating consequence of cancer that contributes to in
59 Diseases of the spinal cord often have
devastating consequences and imaging studies are indispe
60 such events under climate change could have
devastating consequences for global biodiversity.
61 ptomatic in the immunocompetent, it can have
devastating consequences in those with compromised or un
62 niae infection can result in bacteremia with
devastating consequences including heart damage.
63 To prevent the
devastating consequences of anthropogenic global heating
64 Viral infections during pregnancy can have
devastating consequences on pregnancy outcomes, fetal de
65 Despite
devastating consequences to patients' quality of life, t
66 mmed process, the failure of which can bring
devastating consequences to the mother and fetus.
67 tion therapies in Africa would probably have
devastating consequences, and continued surveillance for
68 can report different values with potentially
devastating consequences, such as recommending to termin
69 alth among Americans to spread rapidly, with
devastating consequences.
70 f and other, which when impaired can lead to
devastating consequences.
71 enza strain might have potentially even more
devastating consequences.
72 gering global concern over these potentially
devastating consequences.
73 e resulted in deferred cancer surgeries with
devastating consequences.
74 Perinatal hepatic inflammation can have
devastating consequences.
75 ns occurs in a minority of individuals, with
devastating consequences.
76 2 (SARS-CoV-2) is the causative agent of the
devastating COVID-19 lung disease pandemic.
77 nt RNA virus, is responsible for the present
devastating COVID-19 pandemic.
78 are also many species that persist following
devastating declines due to disease.
79 ect neural development and contribute to the
devastating developmental and neurological anomalies obs
80 EMENT Pontocerebellar Hypoplasia Type 3 is a
devastating developmental disorder associated with sever
81 Nuclear war, beyond its
devastating direct impacts, is expected to cause global
82 Necrotizing enterocolitis (NEC) is a
devastating disease affecting premature infants with int
83 Available treatments for this
devastating disease are few and have limited efficacy, p
84 increase, new treatment strategies for this
devastating disease are urgently needed.
85 Malaria is a
devastating disease caused by Plasmodium parasites, resu
86 es is a necessary step in controlling future
devastating disease emergences.
87 rtant role.IMPORTANCE African swine fever, a
devastating disease for domestic pigs and wild boar, is
88 African swine fever (ASF) is a
devastating disease for domestic pigs.
89 st Meningococcus B, for prevention from this
devastating disease in infants and adolescents.
90 Fire blight is a
devastating disease of apple and pear caused by the bact
91 HB) caused by Fusarium graminearum (Fg) is a
devastating disease of crops, especially wheat and barle
92 us Magnaporthe oryzae causes blast, the most
devastating disease of cultivated rice.
93 ighly pathogenic avian influenza (HPAI) is a
devastating disease of poultry and a serious threat to p
94 Necrotizing enterocolitis (NEC) is a
devastating disease of premature infants with high morta
95 e underlying ELP1 splicing defect can rescue
devastating disease phenotypes and is therefore a viable
96 ities, the exact molecular mechanism of this
devastating disease remains obscure.
97 The treatment of lymphatic anomaly, a rare
devastating disease spectrum of mostly unknown etiologie
98 ch as pregnant women is essential to prevent
devastating disease such as that which was experienced w
99 cinia striiformis f. sp. tritici (Pst), is a
devastating disease that causes significant global grain
100 Many pathogens that caused
devastating disease throughout human history, such as Ye
101 Tomato spotted wilt virus (TSWV) is a
devastating disease to peanut growers in the South-easte
102 Osteoporosis is a
devastating disease with an essential genetic component.
103 Pulmonary arterial hypertension (PAH) is a
devastating disease with poor prognosis and limited ther
104 nal chemistry to discover new drugs for this
devastating disease.
105 profoundly disrupts immune tolerance in this
devastating disease.
106 rostate cancer, providing insights into this
devastating disease.
107 STAT1-LNK signaling axis in this potentially
devastating disease.
108 ive strategies will be needed to defeat this
devastating disease.
109 in targeted control and elimination of this
devastating disease.
110 K2 might not be useful for treatment of this
devastating disease.
111 to develop new methods in dealing with this
devastating disease.
112 ts could provide novel therapeutics for this
devastating disease.
113 to epidermal keratinocytes and inducing this
devastating disease.
114 o develop novel therapeutics to control this
devastating disease.
115 cycle, that might benefit patients with this
devastating disease.
116 proving medical countermeasures against this
devastating disease.
117 prevention, diagnosis, and treatment of this
devastating disease.
118 s alternative therapy opportunities for this
devastating disease.
119 nt of alternative treatment options for this
devastating disease.
120 Breast cancer brain metastasis (BCBM) is a
devastating disease.
121 is no FDA-approved medication to treat this
devastating disease.
122 SFV genes which are essential to combat this
devastating disease.IMPORTANCE African swine fever virus
123 HLB), or Citrus Greening, is one of the most
devastating diseases affecting agriculture today.
124 will become standard of care for a number of
devastating diseases in the coming decade.
125 The fungus Magnaporthe oryzae causes
devastating diseases of crops, including rice and wheat,
126 ous diseases, there remain numerous globally
devastating diseases without fully protective vaccines,
127 romising therapeutic target to treat several
devastating diseases, including epilepsy.
128 ment of small-molecule therapeutics to treat
devastating diseases.
129 inue to provide critical insights into these
devastating diseases.
130 te respiratory distress syndrome (ARDS) is a
devastating disorder characterized by diffuse inflammati
131 n novel therapeutic approaches to treat this
devastating disorder.
132 s disease, and how to monitor and treat this
devastating disorder.
133 e fundamental mechanistic insights into this
devastating disorder.SIGNIFICANCE STATEMENT Pontocerebel
134 Developmental epileptic encephalopathies are
devastating disorders characterized by intractable epile
135 heterogeneous group of inherited or acquired
devastating disorders that affect the energy metabolism
136 mum temperature and duration as the cause of
devastating disturbances in coral reefs, kelp forests, a
137 Maternal mental illness can have a
devastating effect during the perinatal period, and has
138 mand for rhino horn is driving poaching with
devastating effect for the few individuals left of the f
139 Amputations in patients with diabetes have a
devastating effect on quality of life and are associated
140 Aging has a profound and
devastating effect on the brain.
141 Finally, the report discusses the
devastating effect the animal rights movement and advers
142 The
devastating effects and incurable nature of hereditary a
143 iculata and Calonectria henricotiae, has had
devastating effects in gardens since its first appearanc
144 ation of damaged metabolites likely triggers
devastating effects in tissues such as the brain and the
145 These disorders have
devastating effects in young children, and current thera
146 digenous communities best mitigate potential
devastating effects of COVID-19?
147 reby decreasing streamflow, with potentially
devastating effects on aquatic ecosystems.
148 Despite its
devastating effects, very little is known about how ZIKV
149 so causes sporadic pandemics, which can have
devastating effects.
150 eribacter taxon have produced pathogens with
devastating effects.
151 ting of terrestrial ecosystems following the
devastating end-Permian mass extinction.
152 se, which has marked European history with a
devastating epidemic at the end of the 15(th) century.
153 , with over 28,000 reported infections; this
devastating epidemic emphasized the need to understand t
154 trials in the midst of a rapidly spreading,
devastating epidemic for which there was no effective tr
155 l role in the prevention and control of this
devastating epidemic.
156 Arguably, the most
devastating example of endocrine disruption occurred in
157 Homelessness is a
devastating experience for children and their families.
158 lub Impact may not be considered as the most
devastating extinction event for the community.
159 Soil salinity is one of the most
devastating factors threatening cultivable land.
160 nitive impairment, but might also experience
devastating features, such as memory loss, seizures and
161 management strategies for this economically
devastating fish-pathogenic oomycete A. invadans.
162 sequence, abnormal pre-mRNA splicing can be
devastating for the encoded protein, inducing a frameshi
163 pregnancy or within 6 weeks of childbirth is
devastating for the mother and her family, yet data rega
164 POI is particularly
devastating for young girls reaching puberty, because it
165 Glioblastoma is a
devastating form of brain cancer.
166 Temporal lobe epilepsy (TLE) is a common and
devastating form of human epilepsy that lacks preventive
167 Intracerebral hemorrhage (ICH) is a
devastating form of stroke affecting millions of people
168 ia graminis Pers. f. sp. tritici (Pgt), is a
devastating fungal disease threatening global wheat prod
169 tritici (Pgt), is a
devastating fungal disease threatening global wheat prod
170 Thanatephorus cucumeris) is one of the most
devastating fungal diseases which cause severe loss to r
171 Necrotizing enterocolitis (NEC) is a
devastating gastrointestinal disease of incompletely und
172 Necrotizing enterocolitis (NEC) is a
devastating gastrointestinal emergency of neonates.
173 may explain the evolutionary persistence of
devastating genetic diseases such as Huntington's diseas
174 pink bollworm (Pectinophora gossypiella), a
devastating global cotton pest.
175 omising antifungal drug lead to help address
devastating global fungal pathogens such as C. auris.
176 d pandemic influenza outbreaks, which pose a
devastating global health concern.
177 ID-19) pandemic caused by SARS-CoV-2 has had
devastating global impacts and will continue to have dra
178 COVID19 is a
devastating global pandemic with epicenters in China, It
179 Streptococcus pneumoniae is a
devastating global pathogen.
180 e disorder (AUD) is a chronic condition with
devastating health and socioeconomic effects.
181 Septic shock is a
devastating health condition caused by uncontrolled seps
182 e editing for novel plant resistance against
devastating HLB.
183 eted therapeutic strategies for treating the
devastating human cancers associated with this new tumor
184 on inherited gene variants, plays a role in
devastating human conditions such as mitochondrial neuro
185 Smallpox, one of the most
devastating human diseases, killed between 300 million a
186 nto the pathogenesis and penetrance of these
devastating human diseases.
187 ensitive, deployable tests to diagnose these
devastating human diseases.
188 n malnutrition reminiscent of kwashiorkor, a
devastating human malnutrition syndrome.
189 transferase, and amidotransferase, result in
devastating human metabolic disorders.
190 ling them to propagate efficiently and cause
devastating human pandemics.
191 Alcohol use disorder (AUD) is a
devastating illness defined by periods of heavy drinking
192 Schizophrenia is a
devastating illness that affects over 2 million people i
193 In response to
devastating illness, patients and families are frequentl
194 ated disease, COVID-19, has demonstrated the
devastating impact of a novel, infectious pathogen on a
195 gs may be one way to assist in combating the
devastating impact of ASFV.
196 novel intervention strategies to combat the
devastating impact of malaria.
197 As the world attempts to cope with the
devastating impact of the COVID-19 pandemic, researchers
198 Invasive fungal infections have a
devastating impact on human health worldwide, killing ~1
199 This pathogen has had a
devastating impact on larch plantations in the United Ki
200 and decreased water availability, can have a
devastating impact on plant growth and productivity, pot
201 COVID-19 has had a
devastating impact on the care of cancer patients.
202 fungal species are plant pathogens and have
devastating impacts on agriculture.
203 he recent African swine fever epidemic, with
devastating impacts on economy.
204 Marine heatwaves (MHWs) can cause
devastating impacts to marine life.
205 Considering the
devastating implications of nitrogen cycle disruption, t
206 ic meningitis worldwide and are particularly
devastating in the neonatal population, where they are a
207 Spinal muscular atrophy (SMA) is a
devastating infantile genetic disorder caused by the los
208 Tuberculous meningitis (TBM) is a
devastating infection of the central nervous system lack
209 Necrotizing fasciitis and myositis are
devastating infections characterized by high mortality.
210 e been utilized in attempts to control these
devastating infections, such as combinations of various
211 he etiological agent behind some of the most
devastating infectious disease pandemics to date, and in
212 tists are pathogens leading to a spectrum of
devastating infectious diseases.
213 The
devastating inherited disease cystic fibrosis (CF) is ca
214 Parkinson disease (PD) is a
devastating,
largely nonfamilial, age-related disorder c
215 rate, but standard treatments often lead to
devastating life-long side effects and recurrence is fat
216 tation (VCA) allows tissue replacement after
devastating loss but is currently limited in application
217 The
devastating loss of diversity at the base of ocean food
218 .IMPORTANCE Thrips-transmitted viruses cause
devastating losses to numerous food crops worldwide.
219 effect is widely documented and can lead to
devastating losses, the underlying psychological mechani
220 regeneration is essential for recovery from
devastating lung diseases.
221 roid lipofuscinoses) constitutes a family of
devastating lysosomal storage disorders that collectivel
222 Devastating macrovascular complications (cardiovascular
223 Cognitive impairment is a common and
devastating manifestation of multiple sclerosis (MS).
224 The slow, continuous,
devastating march of Alzheimer's disease continues to mo
225 ce temperature (SST) anomalies that produced
devastating marine impacts in the Northeast Pacific duri
226 Depression is a
devastating mental disorder that affects millions of peo
227 for the early intra-mammalian stage of this
devastating metazoan parasite.
228 ine has been traditionally attributed to the
devastating Mongol invasion of the early-13th century CE
229 ceroid lipofuscinoses (NCLs) are a group of
devastating monogenetic lysosomal disorders that affect
230 Strongyloidiasis can cause
devastating morbidity and death in immunosuppressed pati
231 Friedreich's ataxia (FRDA) is a
devastating,
multisystemic disorder caused by recessive
232 oencephalopathy (PML) is a rare, potentially
devastating myelin-degrading disease caused by the JC vi
233 hquakes are responsible for some of the most
devastating natural disasters(1).
234 Trypanosomiasis is a
devastating neglected tropical disease affecting livesto
235 Biliary atresia (BA) is a
devastating neonatal cholangiopathy that progresses to f
236 alent form of dementia, is a progressive and
devastating neurodegenerative condition for which there
237 Amyotrophic lateral sclerosis (ALS) is a
devastating neurodegenerative disease affecting motor ne
238 Amyotrophic lateral sclerosis (ALS) is a
devastating neurodegenerative disease for which the orig
239 cause amyotrophic lateral sclerosis (ALS), a
devastating neurodegenerative disease.
240 in aggregates that are notorious for causing
devastating neurodegenerative diseases in mammals.
241 evelopment of effective treatments for these
devastating neurodegenerative diseases.
242 Alzheimer's disease is a
devastating neurodegenerative disorder with no cure.
243 to changes induced by genetic disorders with
devastating neurodevelopmental deficiencies.
244 Rett Syndrome is a
devastating neurodevelopmental disorder resulting from m
245 NA-binding repressor protein MeCP2 cause the
devastating neurodevelopmental disorder Rett syndrome.
246 tion of adult CNS axons is abortive, causing
devastating neurologic deficits.
247 Alzheimer's disease (AD) is a
devastating neurological disorder characterized by chang
248 While generally considered for its
devastating neurological phenotype, disturbances in othe
249 Duchenne muscular dystrophy (DMD) is a
devastating neuromuscular disease that causes progressiv
250 ll head circumference) produces particularly
devastating neuropathology.
251 usceptibility to developing schizophrenia, a
devastating neuropsychiatric disease with high heritabil
252 en unexpected death of an infant (SUDI) is a
devastating occurrence for families.
253 worldwide and perhaps the most puzzling and
devastating of all human behaviors.
254 al host.IMPORTANCE Marek's disease (MD) is a
devastating oncogenic disease that affects the poultry i
255 r life, and eating disorders often result in
devastating or life-threatening conditions.
256 African meningitis belt were susceptible to
devastating outbreaks, largely attributed to serogroup A
257 currence rates after kidney transplant, with
devastating outcomes.
258 Malaria, the world's most
devastating parasitic disease, is transmitted between hu
259 ndromes in squash (Cucurbita moschata), is a
devastating pathogen worldwide.
260 Plant-parasitic nematodes are
devastating pathogens of many important agricultural cro
261 potential therapeutic target to tackle this
devastating pathology.
262 Rhabdomyosarcoma (RMS) is a
devastating pediatric sarcoma.
263 Especially
devastating periods of coral loss frequently occur durin
264 the United States, some populations of this
devastating pest have rapidly evolved practical resistan
265 his sacchari Zehntner), a relatively new and
devastating pest of sorghum in the United States.
266 erapies to control citrus greening and other
devastating plant diseases caused by fastidious pathogen
267 infection-related development by a globally
devastating plant pathogenic fungus and to determine how
268 ld represent a therapeutic approach for this
devastating progeroid syndrome.
269 Pulmonary Fibrosis (IPF) is a disease with a
devastating prognosis characterized by unrelenting lung
270 le: Idiopathic pulmonary fibrosis (IPF) is a
devastating progressive disease with limited therapeutic
271 Alcohol use disorder (AUD) persists as a
devastating public health problem; widely effective phar
272 tensified to a Category 5 storm within 24 h,
devastating Puerto Rico.
273 Chordoma is a
devastating rare cancer that affects one in a million pe
274 s, the virus is responsible for a variety of
devastating sequelae in immunocompromised adults and in
275 y and thus likely contributes to many of the
devastating sequelae of chronic pain, including the poor
276 s in lactate are a key feature of this often
devastating severe mental illness.
277 In a few
devastating short months in 2020, the coronavirus diseas
278 Ischemia reperfusion (IR) injury results in
devastating skeletal muscle fibrosis.
279 The biology of harlequin ichthyosis (HI), a
devastating skin disorder caused by loss-of-function mut
280 ene therapy is a promising approach to treat
devastating skin fragility diseases.
281 lly changed the structure of our lives, with
devastating social and economic consequences that are li
282 NCE STATEMENT Heightened aggression can have
devastating social consequences and may be associated wi
283 tal adenocarcinoma (PDAC) is one of the most
devastating solid malignancies, with only 9% of patients
284 Metastasis is the most
devastating stage of cancer progression and causes the m
285 While root diseases are among the most
devastating stresses in global crop production, our unde
286 ous deep intracerebral hemorrhage (ICH) is a
devastating subtype of stroke without specific treatment
287 lasmic large DNA virus (NCLDV) that causes a
devastating swine disease currently present in many coun
288 In addition to the
devastating symptoms of dementia, Alzheimer's disease (A
289 Outbreaks of this disease are
devastating the swine industry from Central Europe to Ea
290 The disease is
devastating the swine industry in Central Europe and Eas
291 the apex of an entropic hierarchy and impart
devastating therapy resistance.
292 isease is not a rare disorder, and it can be
devastating to the affected man.
293 that infiltrate tissues and organs to become
devastating tumors.
294 toma multiforme (GBM) is the most common and
devastating type of primary brain cancer.
295 s ruminants (PPR) is a highly contagious and
devastating viral disease affecting mainly sheep and goa
296 outh disease virus (FMDV) is one of the most
devastating viral pathogens of cloven-hoofed animals.
297 ssay for White Spot Syndrome Virus, the most
devastating virus impacting global shrimp aquaculture.
298 Cachexia, a
devastating wasting syndrome characterized by severe wei
299 Duchenne muscular dystrophy (DMD) is a
devastating X-linked disease affecting ~1 in 5000 males.
300 Infectious endophthalmitis is a
devastating,
yet rare, complication after intraocular su