ライフサイエンスコーパス: development

1 ibiotics and many inhibitors are in clinical development.

2 is that bnAb expression often hinders B cell development.

3 m with infant growth and motor and cognitive development.

4 e digit number, body patterning, and cardiac development.

5 not alter zebrafish embryos' morphology and development.

6 d BOC to HH-dependent mammalian craniofacial development.

7 e(s) regulating FGF signaling during nephron development.

8 insight into the regulation of monocot stem development.

9 increased susceptibility of females for FECD development.

10 euronal transmission, immuno-reactivity, and development.

11 l to identify novel drug targets and vaccine development.

12 or use of preclinical models for therapeutic development.

13 thma on childhood asthma or recurrent wheeze development.

14 he clinical course of TS in individuals over development.

15 middle-income countries who have compromised development.

16 etwork robustness has frustrated therapeutic development.

17 portant role in cardiovascular disease (CVD) development.

18 ide insight into the cellular basis of islet development.

19 ge, 20 (AM-6494) was advanced to preclinical development.

20 ds many of the proteins essential for cancer development.

21 ation associated with venous thromboembolism development.

22 large viruses and should aid in ASFV vaccine development.

23 acentae grow heavily, on placental and fetal development.

24 nsive regulatory mechanisms for craniofacial development.

25 igate the effect of PCE on early human brain development.

26 rate its necessity for multicellular rosette development.

27 ne silencing that is essential for embryonic development.

28 Pattern formation is a key aspect of development.

29 is offered, which should aid future reaction development.

30 e impact of H3 variants on various facets of development.

31 the brain during childhood and affect brain development.

32 terminus of p73 is essential for hippocampal development.

33 1 are not required for restricting inclusion development.

34 synthesis of LA is essential for C. elegans development.

35 tially expressed in root system during plant development.

36 cyst involvement in sporadic ovarian cancer development.

37 ogenesis and normal postembryonic growth and development.

38 hTau pathogenicity is specific to postnatal development.

39 functional network connectivity during early development.

40 sion during the parasitic stages of nematode development.

41 id synthesis to critically support embryonic development.

42 detailed road map of basophil and mast cell development.

43 tric patients correlates with severe disease development.

44 y activates genes involved in erythroid cell development.

45 nd senescent placenta that impairs embryonic development.

46 plays an important role during early kidney development.

47 h, a critical regulator of B cell and T cell development.

48 ental knowledge might inform future clinical developments.

49 y were significantly associated with Crohn's development (100% vs 11%; P < 0.01) compared with mild o

50 We recommend (a) the further development and application of biosecurity measures by a

51 Herein, we report the development and application of three catalytic systems (

52 important regulatory role in oligodendrocyte development and CNS myelination.

53 data reveal the status of regional economic development and contain valuable information of human mo

54 of the stress response protein regulated in development and DNA damage 1 (REDD1) is necessary for th

55 ng the formation of coronary arteries during development and during cardiac neovascularization after

56 Despite this central role in development and evolution, the LPM remains challenging t

57 mixed oriented microtubules promote dendrite development and facilitate polarized cargo trafficking;

58 Although altered interneuron development and function are clearly demonstrated in RTT

59 However, how seipin regulates adipocyte development and function remains incompletely understood

60 Here, we discuss genetic models of mouse DC development and function that have aided in correlating

61 for future assessment of primate trophoblast development and function.

62 We suggest that economic development and gender equality in rights go hand-in-han

63 s for orchestrating stepwise adult stem cell development and has also provided useful resources and t

64 ing can influence FXR1 condensates in muscle development and how mis-splicing promotes disease.

65 of the biology of neural progenitors during development and in adult neurogenic niches.

66 er, the impacts on post-transmission disease development and infectiousness in contact individuals ar

67 t TET2 plays a pivotal role in mammary gland development and luminal lineage commitment.

68 r results reveal anatomic control of NK cell development and maintenance as tissue-resident populatio

69 one and low prenatal oestrogen inhibits lung development and may predispose individuals to be vulnera

70 tions of these findings for COVID-19 vaccine development and our approach to optimizing for safety an

71 tenoids serve essential roles in chloroplast development and photosynthesis.

72 tion and also involved in megakaryocyte (MK) development and platelet production.

73 The assay development and qualification data for this original ass

74 PS components contributes to oligodendrocyte development and repair and reveal a new role for Nedd4 i

75 These data give insights into the development and selection of humanized animal antibodies

76 ) play key roles in regulating plant growth, development and stress adaptations.

77 analyzing Atoh7 mRNA and protein levels, RGC development and survival, and chromatin landscape effect

78 tions for anti-Alzheimer's research and drug development and the broader field of tauopathies in gene

79 ow these properties contribute to intestinal development and the dynamics of injury-induced regenerat

80 T5 is critical for post-thymic gammadeltaT17 development and tissue-specific imprinting, which is ess

81 rstand how locomotor synergies change during development and training by studying the synergies for r

82 Here, we describe the development and use of an assay to monitor the incidence

83 EMT is crucial to embryonic development and wound healing.

84 ddressed, this article aims to review recent developments and technical breakthroughs including optic

85 in PVEC vs. ABEC identified "Nervous system development" and "Response to Stress" as the top signifi

86 essential roles in animal evolution, tissue development, and homeostasis, and are disrupted in human

87 ght emerging scientific innovations in model development, and introduce a conceptual framework for us

88 sful application in pharmaceutical research, development, and manufacturing.

89 tions in visceral adipose tissue and hepatic development, and persistent diet-responsive transcriptio

90 icated as contributors to cancer genesis and development, and the search to identify and characterize

91 clinical trials, with others in preclinical development, and the targeting of Na(V)1.9, although ham

92 ding the pathogenesis of SARS-CoV-2, vaccine development, and therapeutic testing.

93 ssential in forming new neurocircuits during development, and this is mediated in part by astrocyte-r

94 le in microbial defense, inflammation, organ development, and tissue regeneration.

95 Transcriptional regulation of AZ development appears to be extensively rewired among the

96 nsory feedback related to peripheral fatigue development are thought to restrict motor unit activatio

97 ard) versus intramural (KL2) or other career development award funding (55% vs 33%, P = 0.03) and mor

98 and 19 years, respectively, and a NIH Career Development Award.

99 showed defective pollen tube growth and seed development because of nonviable mutant gametes.

100 s (ECs) display remarkable plasticity during development before becoming quiescent and functionally m

101 useful for antibody screening, custom assay development, biomarker detection, and protein profiling

102 overed several that were heavily enriched in development but reduced in adulthood, including the tran

103 mily fulfil important functions during grain development but, with the exception of HvCslF6, do not i

104 enerating and maintaining NPCs during kidney development, but little is known about the molecule(s) r

105 This study strongly supports future TBI development by providing a rational method to compare di

106 Treg cells can be generated during thymic development (called thymic Treg [tTreg] cells) or derive

107 th excitatory and inhibitory synapses during development can potentially contribute to developmental

108 MondoA in the regulation of early vertebrate development, connecting glucose, cholesterol and steroid

109 Experimental developments continue to challenge the theoretical descr

110 nd Mohn Foundation, and Norwegian Agency for Development Cooperation.

111 Early childhood development (ECD) programmes can help address early disa

112 ays the groundwork to streamline future drug development efforts.

113 ach as a potential addition to Ebola vaccine development efforts.IMPORTANCE Ebola outbreaks result in

114 Here, we explore speciation alongside development, emphasizing their mutual dependence on gene

115 This paper outlines the in vitro formulation development for hydrogel-forming microneedle arrays cont

116 Evidence-based guideline development for surgical and dental prescribing is warra

117 l responses were tracked over their complete development, from early instar larvae to adult death.

118 e nonconventional ubiquitin chains in neural development, function, plasticity, and related pathologi

119 In the context of the Sustainable Development Goals and the shifting global burden of dise

120 ard achieving the United Nations Sustainable Development Goals.

121 impact of the global cytosine-5 methylome on development, homeostasis and stress remains unknown.

122 Dietary lipids impact development, homeostasis, and disease, but links between

123 rboring genes with prominent roles in T cell development in both strains.

124 hlight the challenges for successful vaccine development in each phase.

125 differential trajectories of gut microbiota development in humans and chimpanzees that are consisten

126 ablish conserved aspects of sex-biased brain development in humans and mice, and shed light on the co

127 del and was related to reducing PTSD symptom development in humans.

128 in regulating cellular processes in vivo and development in metazoans remains to be understood.

129 (HB-EGF), a crucial regulator of heart valve development in mice.

130 X1 is required for systemic lymphatic vessel development in prenatal mice and it is critical for thei

131 lications across disease prediction and drug development in relation to the COVID-19 pandemic are rev

132 , there is an implied stage of human NK cell development in which DNA demethylation takes place to al

133 ll transcriptomic analysis of hematovascular development in wild-type and etv2 mutant zebrafish embry

134 In the Coronary Artery Disease Risk Development in Young Adults study, a cohort of black and

135 Inspired by developments in asymmetric organocatalysis, where reacti

136 histology and mutation information, with new developments in DNA methylation classification.

137 We survey how the recent developments in genetics are beginning to provide social

138 s-acting lncRNAs in vivo, and generating new developments in high-throughput screening used to identi

139 Recent developments in SPECT hardware include solid-state digit

140 With new developments in the area of advanced biobased fibers, it

141 raves orbitopathy and summarize the research developments in this area to highlight future research q

142 late discussions in the community on further developments in this field, rather than being an in-dept

143 Here, we highlight the developments in understanding TIM3 biology, including no

144 togenesis and corticogenesis during prenatal development, in both males and females.

145 , the renewable electricity facilities under development increasingly overlap with conservation areas

146 portionally, countries with a low UNDP human development index (HDI) faced a greater burden of premen

147 ountry-level associations between the gender development index and the expected length of time in edu

148 hese species during inflorescence and floral development is essential to understand their role in the

149 ellular and molecular mechanism driving root development is mainly based on studies of the dicot mode

150 Hair follicle (HF) development is orchestrated by coordinated signals from

151 An important question in early neural development is the origin of stochastic nuclear movement

152 ociative brain regions is established during development is unknown.

153 of the disease, tools to facilitate vaccine development must be identified.

154 , the kinetic pathways, following which such development occurs, have been largely unexplored due to

155 facial energy and self-healing capabilities, development of "anode-free" Li batteries to minimize the

156 in EOC-derived fibroblasts that suggest the development of a malignant tumor microenvironment.

157 the model label was adequate for use in the development of a naloxone product intended for over-the-

158 In the present study, we report the development of a rapid, sensitive, robust, reliable, and

159 Here, we traced the cellular development of a recently evolved morphological novelty,

160 be and make specific recommendations for the development of a stronger evidence base, with the hope t

161 Here we report the development of a tantalum oxide nanoparticle (NP)-based

162 hymocyte differentiation associated with the development of a thymic medulla.

163 r exogenous administration, we report on the development of a unique hydrogen peroxide (H(2) O(2) )-s

164 High HKDC1 levels were associated with the development of acute kidney injury and decreased surviva

165 volutional neural networks, have enabled the development of AF screening pathways using the ubiquitou

166 nism and role of various tick species in the development of AGS.

167 traditional factors, might contribute to the development of AKI in patients with cirrhosis.

168 choline receptors (nAChRs) as a lead for the development of alternative antivenoms.

169 The mechanistic insights enabled development of an electrochemically driven photochemical

170 The recent development of an in vivo solid-phase microextraction (S

171 o a starting point for future efforts in the development of anti-TB drugs.

172 ter 3 to 6 weekly doses, coincident with the development of antidrug antibodies (ADAs) against each o

173 se is a well-established risk factor for the development of atopic dermatitis (AD), but several aspec

174 in genetically susceptible children with the development of autoantibodies against (pro)insulin in ea

175 ssel vasculitis and are characterized by the development of autoantibodies to the neutrophil proteins

176 in Cardiology Challenge 2019 facilitated the development of automated, open-source algorithms for the

177 ous monitoring of propofol is crucial in the development of automatic systems for control of drug inf

178 Herein, we review the development of biomaterials suited for light-based 3D pr

179 at 1 year after HTx are associated with the development of CAV.

180 Strategies to reduce the development of celiac disease have not been proven succe

181 ental and stem cell biology have allowed the development of cell-replacement therapies that comprise

182 the pathogenesis of immune function and the development of CF lung disease.Methods: We performed sin

183 of serum biomarkers were associated with the development of clinical AD; especially, the time-specifi

184 ed microvascular perfusion is central to the development of coma and lactic acidosis in severe falcip

185 ar diet, are known to play a key role in the development of Coronary Heart Disease.

186 SARS-CoV-2 is responsible for the development of coronavirus disease 2019 (COVID-19) in in

187 he type 2 immune response that may favor the development of cryptococcal disease and the fungal disse

188 A critical limitation preventing the development of curative strategies is the lack of knowle

189 rameters were increasingly abnormal with the development of dark flecks and decreasing qAF.

190 of hunger-promoting AgRP neurons during the development of diet-induced obesity in mice.

191 nce with moving stimuli is necessary for the development of direction selectivity in visual cortex of

192 characterized by the loss of fresh fruit and development of dried fruit flavors.

193 ation of genes in uterine tissue and optimal development of estrogen responses in this tissue.

194 Unlike sway minimisation, development of force accuracy was associated with learni

195 In conclusion, development of functional antibodies follows survival of

196 (HPCs) at the periportal area and subsequent development of HCCs.

197 rkers in middle age are at high risk for the development of heart failure with preserved ejection fra

198 catenated nitrogen compounds of interest for development of high-energy-density materials, including

199 erage window of over three years between the development of high-grade dysplasia and pancreatic cance

200 tic defect in SHR that may contribute to the development of hypertension.

201 with potentially broad implications for the development of immunotherapies and vaccines.

202 overning parameters complicates analysis and development of improved mixture-based, high-throughput d

203 These mAbs provide a blueprint for the development of improved vaccines and therapeutics agains

204 To inform the development of insect-based foods, we analysed selected

205 letal muscle is thought to be related to the development of insulin resistance and type 2 diabetes.

206 The last decades have seen an impressive development of iron complexes involving organophosphorus

207 of chemical structure prediction enables the development of machine-learning methods to predict the l

208 ologists have traditionally thought that the development of Maya civilization was gradual, assuming t

209 l this important trait and further allow the development of molecular markers to utilise this trait t

210 es that occur in these tissues may guide the development of more efficacious antidepressant treatment

211 r epitope conservation, provide insights for development of more universal SARS-like coronavirus vacc

212 t it is unclear whether it has a role in the development of multicellular systems.

213 Development of multicellularity was one of the major tra

214 e adaptive-response mechanisms underlies the development of myeloid leukaemia.

215 sting methods, such as those established for development of national surgical, obstetric, and anesthe

216 ctional and morphologic changes indicate the development of nephrotic syndrome in mice bearing the As

217 The development of new CRISPR-Cas genome editing tools conti

218 shed light on the promise they hold for the development of new management strategies in agriculture

219 tumour metabolism is being redefined by the development of new molecular tools, tumour modelling sys

220 mechanisms of iron biology but also for the development of new pharmacologic agents that exploit or

221 naling underlying cancer cell metabolism and development of new strategies for the treatment of letha

222 dopamine-denervated striatum may prompt the development of new therapeutic principles for Parkinson'

223 ntain a persistent infection may lead to the development of new therapeutic strategies against chroni

224 medical images as well as the discovery and development of new therapies.

225 There is a great need for the development of next generation instrumentation and techn

226 To conclude, an outlook on the development of next-generation TE materials in line with

227 racterize, dissect and validate QTL, but the development of NILs is costly.

228 he ability to study sleep in dogs, including development of non-invasive polysomnography; however, ba

229 The development of novel data-driven functional analytic too

230 sents a very valuable starting point for the development of novel wound-healing promoters.

231 ticle focuses on the recent advances for the development of ocular drug delivery systems.

232 nvestigation of the above issues and thereby development of optimal strategies for accurate tissue an

233 aterials, use of ion exchange membranes, and development of other sensor components, as further descr

234 robiome, and consequently contributed to the development of overt skin disease.

235 nd DNA damage 1 (REDD1) is necessary for the development of oxidative stress in the retina of strepto

236 be presented on the cancer cell surface, the development of personalized cancer vaccines based on IR-

237 mechanistic framework of brain IR in further development of personalized medicine strategies to effec

238 Such a model could aid in the development of prebiotic, probiotic, or synthetic therap

239 the primary tumour, MDSCs contribute to the development of premetastatic niches and settlement of re

240 e-consuming and costly, which has led to the development of programmes for performing computational a

241 ur understanding of false memories or of the development of recollection and familiarity.

242 ting that OsNLA1 is important throughout the development of rice.

243 The development of robust catalytic methods to assemble tert

244 ogical and ecological investigations for the development of safe and efficient biological control pro

245 animal model of COVID-19 that may facilitate development of SARS-CoV-2 therapeutics and vaccines.

246 ffects in humans and wildlife has led to the development of scientific and regulatory approaches for

247 roliferative neoplasm (MPN) are prone to the development of second cancers, but the factors associate

248 Despite the development of second-generation antiandrogens, acquired

249 linical sepsis was associated with the later development of secondary Candida infection.

250 compartment predispose aged mice toward the development of severe corneal epithelial disease after e

251 tion between maternal place of birth and the development of severe pre-eclampsia.

252 The development of single-cell RNA sequencing (scRNA-seq) ha

253 Development of small molecule compounds that target seve

254 Development of specific sensor technologies integrating

255 As in embryogenesis, the development of structure inside a cell can be broken dow

256 ally, we provide an outlook about the future development of synthetic 2D CCFs for electrochemical app

257 represents a significant step forward in the development of synthetic materials that rival their high

258 This has prompted the development of synthetic membranes to study lipid-lipid

259 Bcl6 is required for the development of T follicular helper cells and T follicula

260 We show that in vitro development of tamoxifen-resistance is associated with i

261 fied phenomenon that forms the basis for the development of TBV.

262 omer complex system is an early event in the development of the AD-like pathology and cognitive decli

263 In particular, we highlight the development of the atomic force microscope to investigat

264 inkage of her1 and her7 is essential for the development of the body axis in zebrafish embryos.

265 proteins has been rapidly expanding owing to development of the chemoproteomic techniques.

266 s network impacts not only the socioeconomic development of the concerned regions but also their ecos

267 n in length but could not predict effects on development of the liver, which was the tissue most sens

268 -1 receptor and has an important role in the development of the nervous system (p = 4.29 x 10(-11) wi

269 Development of the prediction model was based on clinica

270 rtion of the right CB may underlie the early development of the preterm behavioral phenotype.

271 Understanding how RGF1 regulates the development of the root meristem is essential for unders

272 es, inhibition increases strongly during the development of the visual cortex and remains high.

273 ition is a promising avenue to follow in the development of therapeutics for treatment of S. pneumoni

274 protection, but the primary obstacle for the development of this technology is the efficient delivery

275 The development of tools through which the ISR can be modula

276 fibers, which will be of importance for the development of treatments for age-related hearing disord

277 issues that relate to the rapid "Warp Speed" development of vaccines to counter the COVID-19 pandemic

278 ivileged scaffold for further cost-effective development of valuable colistin resistance inhibitors.

279 throughout the filament contribute to force development, only about 10% of the motors in each filame

280 Here, we discuss recent development, optimization, and applications of optical a

281 y lead to new targets or approaches for drug development or treatment regimens that may affect both a

282 people who are the intended beneficiaries of development programming.

283 In the field of analytical calibration, developments regarding the estimation of prediction erro

284 In this review, we summarize the last developments regarding the potential role of hsTYR in hu

285 During development, signaling by this superfamily regulates a v

286 n behavior previously only observed in human development, suggesting a reactivation of developmental

287 MARCKS supports development, synaptic plasticity, and regeneration after

288 Novel drug development, testing and progression to clinical trials

289 h and has implications for ecology and skull development that go beyond paleontology.

290 We discovered that during ligule development, the E class MADS-box TF GRCD5 activates GhC

291 In this Perspective, we highlight recent developments toward innovative medicinal chemistry strat

292 profile and laid the foundation for further developments toward more potent and selective inhibitors

293 y optimistic, as the field of MAGL inhibitor development transitions from preclinical to clinical and

294 even patients developed PGD (38.9%), and PGD development was associated with selective reduction of t

295 control group, and the probability of asthma development was significantly lower.

296 ematopoietic stem cells are generated during development, we performed genome-wide RNA tomography seq

297 search Council, Department for International Development, Wellcome Trust).

298 of a general strategy to accelerate catalyst development which still remains underexplored.

299 t paradigm of traditional drug discovery and development, which usually takes years from start to fin

300 or scheduling the IDC and coordinating their development with host daily rhythms.