ライフサイエンスコーパス: developmental

1 be classified broadly as either synaptic or developmental.

2 nd Hid was probably the underlying cause for developmental abnormalities observed upon dElys depletio

3 Developmental analysis of Ghrh and Kiss1 expression sugg

4 olling cell fate and differentiation in many developmental and adult processes.

5 s of FOXA-dependent epigenomic modulation in developmental and disease processes.

6 erspective establishes unexpected links with developmental and ecological psychology.

7 Developmental and environmental cues were shown to regul

8 significant loci for genetic generalized and developmental and epileptic encephalopathy patients but

9 ological complexities associated with GRIN2A developmental and epileptic encephalopathy.

10 re and have been widely studied from genetic/developmental and evolutionary perspectives.

11 n, and RNA processing, and thereby mediating developmental and metabolic processes related to nitroge

12 ly conserved across species, but the precise developmental and positional patterns of expression and

13 e being produced at an extraordinary pace in developmental and regenerative biology.

14 ure of proteostasis with age is triggered by developmental and reproductive cues that repress the act

15 th internal energy balance to regulate major developmental and reproductive events still remain enigm

16 Advances in developmental and stem cell biology have allowed the dev

17 of MSH1 results in phenotype variability for developmental and stress response pathways.

18 ion techniques are broadly applicable across developmental and systems biology.

19 The described set of morphological, growth, developmental, and neurological findings and medical con

20 titin), a protein that plays key structural, developmental, and regulatory roles in skeletal and card

21 Here, we report that a process we term developmental anoikis distinguishes the pathological det

22 ertoire diversity, decreased BCR editing and developmental arrest of immature B cells, resulting in r

23 e Igf1r deletion allows the evasion of early developmental arrest, interspecies fetuses with high lev

24 ith rapid RBC lysis, or successful entry but developmental arrest.

25 -deficient thymocytes do not account for the developmental arrest.

26 The developmental assembly of this binocular circuit, especi

27 R-128-3p strongly and selectively diminishes developmental astroglial mGluR5 signaling.

28 longation factors as potential regulators of developmental axon regrowth.

29 the host CNS, which promote the homeostatic developmental balance of neural connections during the p

30 icellular bacteria, this can lead to complex developmental behaviors and the formation of higher-orde

31 ed metabolism and many human diseases, we as developmental biologists can contribute skills and exper

32 Developmental biologists have frequently pushed the fron

33 research fields such as genome stability and developmental biology and to test concepts such as phase

34 A major challenge in cell and developmental biology is the automated identification an

35 A central task in developmental biology is to learn the sequence of fate d

36 been a workhorse model organism for studying developmental biology.

37 rting strategies and given new insights into developmental biology.

38 Such developmental blocks may be attributed to the unusual pr

39 We first defined the early developmental boundary between the two tail halves in th

40 with an elevated risk of psychosis and other developmental brain disorders.

41 ques to show that within the Aire-expressing developmental branch, TSA expression peaked as Aire expr

42 How this developmental capacity copes with fluctuations of food a

43 ol exposure (FAE) is the leading preventable developmental cause of cognitive dysfunction.

44 erent types and molecular players regulating developmental cell death, and discusses recent findings

45 In this issue of Developmental Cell, Benedict et al.

46 In this issue of Developmental Cell, Consolati et al.

47 In this issue of Developmental Cell, De Henau et al.

48 In this issue of Developmental Cell, Gandhi et al.

49 In this issue of Developmental Cell, Ho and Treisman uncover a signal tra

50 In this issue of Developmental Cell, Kong et al., 2020 identify members o

51 In this issue of Developmental Cell, Marsh et al.

52 In this issue of Developmental Cell, Matthews et al.

53 In this issue of Developmental Cell, Miao et al.

54 In this issue of Developmental Cell, Sidor et al.

55 ifferences in decision-making competence and developmental changes across the life span.

56 We focus on developmental changes in the ventricular system and CSF

57 h the saliency of odor signals is subject to developmental changes, the stage at which this cortical

58 ation was predominantly a simple reversal of developmental changes, with expression changes not follo

59 rait arising from numerous physiological and developmental characteristics.

60 as a reproductive approach to enhance oocyte developmental competence.

61 Part of the answer relies on the notion of developmental constraints: at any stage of ontogenesis,

62 ies of cell-cycle control in a wide-range of developmental contexts.

63 in depletion is widely applicable in various developmental contexts.

64 essor that regulates neurogenesis in several developmental contexts.

65 We observe enrichment for cardiac muscle developmental/contractile and cytoskeletal genes, highli

66 Understanding how developmental cues and environmental signals impact AM d

67 The developmental cues controlling the differentiation of co

68 In response to environmental or developmental cues, sigma factors initiate the transcrip

69 egin to illustrate how, and explore why, the developmental decision of metamorphosis relies on cues f

70 was, with the exception of a residual T cell developmental defect, completely rescued in irradiated w

71 lso demonstrate that BALOs recapitulate lung developmental defects after knockdown of a critical regu

72 Histological analysis also showed developmental defects in the formation of the fore-, mid

73 n early ablation or overexpression can cause developmental defects or embryonic lethality.

74 airment and loss of dental enamel, caused by developmental defects or tooth decay (caries), affect he

75 year-old left-handed woman with a history of developmental delay and medical refractory seizures sinc

76 P1 is a major genetic risk factor for global developmental delay, autism spectrum disorder, and epile

77 of rare disorders commonly manifesting with developmental delay, cerebral palsy or seizures.

78 individuals presented with hypotonia, global developmental delay, epileptic encephalopathy, and dysmo

79 typical facial dysmorphisms, short stature, developmental delay, intellectual disability as well as

80 hat showed features of early-onset seizures, developmental delay, microcephaly, sensorineural deafnes

81 pectrum of intractable seizure types, severe developmental delay, movement disorders, and elevated ri

82 stature, seizures, cognitive impairment, and developmental delay.

83 more challenging situations in patients with developmental delay.

84 Our analysis demonstrated developmental differences in gene expression and accessi

85 diagnosis of pervasive developmental disorder (PDD) or autistic disorder (AD) a

86 ristianson syndrome, a debilitating X-linked developmental disorder associated with a range of neurol

87 Noonan syndrome (NS) is a multisystemic developmental disorder characterized by common, clinical

88 ons that affect this complex cause the human developmental disorder Cornelia de Lange syndrome (CdLS)

89 a urogenital condition among persons with a developmental disorder to 54.1% for a circulatory disord

90 ls had a diagnosis of Down syndrome or other developmental disorder, while 84 (52.5%) individuals had

91 c abnormalities leads to pathologies such as developmental disorders and malignancies.

92 powerful medium for probing the etiology of developmental disorders associated with 16p11.2 CNVs.

93 8 parent-offspring trios of individuals with developmental disorders, and develop a simulation-based

94 previously undescribed genes associated with developmental disorders, we integrate healthcare and res

95 ehavioral responses.SIGNIFICANCE STATEMENT A developmental disruption of prefrontal cortex maturation

96 Based on the developmental dynamics of brown adipocytes, we propose t

97 sing thresholds have seldom been explored in developmental dyslexia nor its subtypes.

98 The brain is a critical target for developmental endocrine disruption, resulting in altered

99 Severe developmental errors in E- embryos were characterized by

100 hrough the process of gastrulation, an early developmental event that transforms an isotropic group o

101 play a role, providing new insights into the developmental evolution of complex chemosensory systems.

102 t to better understand the species-dependent developmental expression pattern.

103 us, it is important to understand the normal developmental expression profiles of NRGs and ErbBs in s

104 nderstanding of the genetic, epigenetic, and developmental factors driving these cancers.

105 Auxin determines the developmental fate of plant tissues, and local auxin con

106 cking, we aimed to assess the spatiotemporal developmental features of "neural flexibility" during th

107 The ICM therefore provides a developmental framework for explaining variation in mola

108 ely enriched in either population, but whose developmental functions are unknown in these neurons.

109 ly related sea urchins with highly divergent developmental gene expression and life histories.

110 onmental cues, and respond by changing their developmental gene expression.

111 ulatory subunit 12a (PPP1R12A), an important developmental gene involved in cell migration, adhesion,

112 Appropriate developmental gene regulation relies on the capacity of

113 s deficiency leads to impaired activation of developmental genes and subsequent embryonic lethality.

114 2 functions in gene expression by protecting developmental genes from repression via repelling PRC2 a

115 reversible PcG function is essential at most developmental genes.

116 3a and Dnmt3b resulted in failure to silence developmental genes.

117 strategies are internally constrained at the developmental, genetic and phylogenetic level is unknown

118 ies now available to biologists to study the developmental genetics, cell biology and morphogenesis t

119 These data reveal a four-stage developmental hierarchy for Tex cells and define the mol

120 in molar complexity and a means for testing developmental hypotheses in the broader context of mamma

121 tex (PFC) lineages to efficiently test early-developmental hypotheses of autism.

122 ng, we provide experimental evidence for the developmental importance of miRNAs in a non-bilaterian a

123 er than adolescence, a potentially important developmental life stage.

124 CRISPR-Cas9 barcode editing for elucidating developmental lineages at the whole organism level.

125 associated with an atypical profile of this developmental maturation in model-based control.

126 We report that, upon developmental maturation, in mice 30% of the IHCs are el

127 volved in virtually all aspects of postnatal developmental maturation, including mitochondrial energy

128 of tankyrase serves as a ligand-independent developmental mechanism for post-translational beta-cate

129 the Warburg effect is a precisely regulated developmental mechanism that is anomalously reactivated

130 Despite numerous attempts to elucidate the developmental mechanisms responsible for the observed di

131 es of interest to expose the underpinning of developmental mechanisms.

132 grin-mediated adhesion is important for many developmental migration events.

133 maternal to embryonic control is a critical developmental milestone in preimplantation development.

134 Apigenin significantly improved several developmental milestones and spatial olfactory memory in

135 lar hair cell differentiation and supports a developmental model in which Type-I and Type-II hair cel

136 cusps, crests), can be explained by the same developmental model.

137 ong-range looping interactions change across developmental models, genetic perturbations, drug treatm

138 ty-regulated role for microglia in modifying developmental myelin targeting by oligodendrocytes.

139 he E3 ubiquitin ligase Nedd4 is required for developmental myelination through stabilization of VHL v

140 severe forms of the disease with failure of developmental myelination, and more recently, in severel

141 number variations (CNVs) that predispose to developmental neuropsychiatric disorders.

142 rging evidence demonstrates that PCB 11 is a developmental neurotoxicant.

143 he findings indicate that the quality of the developmental niche is associated with the condition-dep

144 and their role in the evolutionary origin of developmental novelties.

145 lutionary integration because of functional, developmental or genetic constraints, conforming to evol

146 with several conceptual questions about the developmental origin of the cell and, consequently, the

147 are not phenocopied by MK-801, suggesting a developmental origin.

148 resents an overview of recent studies on the developmental origins, migratory properties, and morphol

149 phrenia and other psychiatric disorders with developmental origins.

150 t advantages for clinical use and open a new developmental path for a safe and effective vaccine.

151 m the same individual that exhibit different developmental paths toward broad neutralization activity

152 ional antagonism, and governs a multitude of developmental pathways and cell fate decisions that incl

153 MAGE proteins regulate diverse cellular and developmental pathways, implicating them in many disease

154 altered primarily by coding mutations, while developmental pathways, including Wnt and Notch, altered

155 es that underlie emotion recognition and its developmental pathways.

156 d maturation, but may also involve anomalous developmental pathways.

157 The signal furthermore displays a clear developmental pattern because it is only detectable in r

158 ion Normative apparent diffusion coefficient developmental patterns on diffusion-weighted MRI scans w

159 t and changes over time as well as different developmental periods when interpreting clinical symptom

160 eed for clinicians and scientists to adopt a developmental perspective in clinical practice and resea

161 L deficient mice showed no obvious postnatal developmental phenotype.

162 Populations often display consistent developmental phenotypes across individuals despite inev

163 uced cytokinin response, consistent with the developmental phenotypes arising from a defect in cytoki

164 gf8 conditional knockout mice did not reveal developmental phenotypes, the restricted pattern of Fgf8

165 tate the study of important novel aspects of developmental physiology, are extendable to numerous cla

166 Developmental plasticity allows genomes to encode multip

167 pletion suggests a dynamic interplay between developmental plasticity and immune-mediated pruning dur

168 , revealing a complex makeup that also shows developmental plasticity, particularly for 22-nt sRNAs.

169 Here, we uncover developmental pluripotency associated 2 and 4 (DPPA2/4)

170 arently mundane, yet striking feature from a developmental point of view: When the shell is closed, t

171 ed direct RNA sequencing to characterize the developmental polyadenylated transcriptome of C. elegans

172 Neural crest cells have different developmental potencies at different levels along the bo

173 thus establishes a key RNA-based feature of developmental potential and a platform for delineation o

174 rigued investigators owing to its remarkable developmental potential and extensive migratory ability.

175 The developmental potential of cells, termed pluripotency, i

176 )PRLR(+) myeloid progenitors lacked lymphoid developmental potential, but when stimulated with prolac

177 er with cases of microcephaly and associated developmental problems in infants born to women infected

178 by de novo telomere addition, while a normal developmental process in some organisms, has the potenti

179 ions to this framework: a description of the developmental process through which second-personal comp

180 ion, presumably due to the underlying shared developmental process.

181 sitive and negative genetic contributions to developmental processes and cell phenotypes.

182 Motivated by similarities in developmental processes and histological properties betw

183 Differential expression of mi-RNAs targeting developmental processes and progressive downregulation o

184 e pathways associated with multicellular and developmental processes are not under TOD control in W.

185 New cellular functions and developmental processes can evolve by modifying existing

186 -sequencing make it possible to infer latent developmental processes from the transcriptomic profiles

187 s an endogenous signal that triggers crucial developmental processes in filamentous fungi, and opens

188 nal dynamics change over the course of these developmental processes in other plant systems.

189 Our study identifies epidermal developmental processes required for digit separation.

190 dium, and potassium) contributes to in utero developmental processes such as neural proliferation, mi

191 al disorders has prompted the search for key developmental processes that drive changes in risk for p

192 Developmental processes underlying normal tissue regener

193 with splines to capture linear and nonlinear developmental processes.

194 AF complex, which has known contributions to developmental processes.

195 works, hormone signaling pathways, and plant developmental processes.

196 -cell RNA sequencing revealed that epidermal developmental progenitors form a more uniform population

197 rement for MAFB late in the human pancreatic developmental program and identify it as a distinguishin

198 rse clade of animals, with a conserved early developmental program but diverse larval and adult morph

199 B-1 B cells derive from a developmental program distinct from that of conventional

200 Potato tuber formation is a secondary developmental programme by which cells in the subapical

201 ing complexes - regulate gene expression and developmental programmes, and how misregulation of their

202 mechanisms underlying glucocorticoid-induced developmental programming.

203 controls transcriptional activity of various developmental programs and also of embryonic stem cell (

204 also adjust to life stages imposed by novel developmental programs for which they were never molded

205 groups, clouding the homology between their developmental programs.

206 rth, and how they are coordinated with fetal developmental programs.

207 an development, suggesting a reactivation of developmental programs.

208 naling to coordinate axon targeting with the developmental progression of the pharyngeal arches and s

209 ue of this construct for informing models of developmental psychopathology and individual differences

210 g of psychopathology, of development, and of developmental psychopathology per se.

211 ng development can potentially contribute to developmental refinement of neuronal circuits and associ

212 Developmental regression occurred in all Rett syndrome p

213 plementation of rodent blastocysts lacking a developmental regulatory gene can generate xenogeneic pa

214 b7, a transcription factor that is part of a developmental regulatory system and a ureteric bud marke

215 To study how normal developmental remodeling is mediated, we used fluorescen

216 he roles of RGC subclasses in shaping unique developmental responses within the retina and at central

217 But developmental retardation, reduced brood size, altered s

218 rged as a model system for investigating the developmental roles of glucocorticoid signaling and the

219 or associations in an extensively phenotyped developmental sample of 345 participants (312 healthy an

220 agnetic resonance imaging studies in healthy developmental samples (i.e., adolescence [10-18 years of

221 lar areas void of astrocyte endfeet, and the developmental shift in microglial migratory behavior alo

222 uration of the transcriptional response to a developmental signal is limited.

223 Interventions across the developmental span, varying risk levels, and service con

224 e immune response, we discuss in broad terms developmental stage and context-dependent functions of l

225 strocaudal dispersion of CINs depends on the developmental stage of the host brain and is limited by

226 A novel crop load x fruit developmental stage protocol for multivariate NIRS-based

227 ling synaptic diversity that is dependent on developmental stage, anatomical region and whether assoc

228 ional activity of these iCGIs is tissue- and developmental stage-specific and, for the first time, we

229 Loss of developmental stage-specific constraint in macrometastas

230 We constructed developmental stage-specific transcriptional regulatory

231 signatures, we identified enhancers for each developmental stage.

232 nal dynamics, sometimes even within the same developmental stage.

233 affected according to the vintage and berry developmental stage.

234 derpinning flexible behavior differed across developmental stages and reduced flexible behavior in AS

235 ted retinal ganglion cells (RGCs) at various developmental stages and RGCs differentiated in vitro fr

236 derived from sexed-sperm were found to reach developmental stages at similar timings as conventional

237 rianth expansion during mid- and late flower developmental stages by promoting cell division in the d

238 vated Dorsal triggers apoptosis during later developmental stages by up-regulating the pro-apoptotic

239 filing a diverse panel of mouse tissues at 8 developmental stages from 10.5 days after conception unt

240 have specific expression patterns at various developmental stages in placenta tissue.

241 ion, the regional distributions at different developmental stages of other markers such as calcium bi

242 tail regeneration-competent and -incompetent developmental stages of Xenopus tadpoles.

243 s of RDI treatments applied at various berry developmental stages on canopy, yield, and free and glyc

244 iology, host modulation and diverse parasite developmental stages using reverse genetics and holds gr

245 At early developmental stages, rnf-145 in the cis-Golgi network i

246 atures in various complex diseases and their developmental stages.

247 xamine their biological functions at defined developmental stages.

248 es of Brachypodium whole-root system at four developmental stages.

249 zed their expression patterns during various developmental stages.

250 g generation of architecture resembling late developmental stages.

251 transcriptomic profiles of cells at various developmental stages.

252 an inherent ability to sense drought at both developmental stages.

253 abundant transcript during plant growth and developmental stages.

254 Certain assumptions underlie current vaccine developmental strategies, including that infection with

255 l halves in the chicken, then followed major developmental structures from early embryo to post-hatch

256 onclude that recent integration of molecular developmental studies with population genetic approaches

257 sitive vesicle activity and is essential for developmental success.

258 The developmental switch of NMDARs from GluN2B-containing ea

259 onal maturation is regulated, we studied the developmental switch of response to the neurotransmitter

260 Developmental synaptic remodeling is important for the f

261 n associated with a severe but heterogeneous developmental syndrome, termed syt1-associated neurodeve

262 development and human disease, specifically developmental syndromes and cancer.

263 nct C. elegans wild isotypes, owing to rapid developmental system drift driven by accumulation of cry

264 ic network features, fitness landscapes, and developmental system drift.

265 that these findings represent an example of developmental system drift.

266 anges in visual experience during a discrete developmental time, the critical period, trigger robust

267 of cytoplasmic calcium levels that fade over developmental time.

268 dels, which differ from humans in both their developmental timeline and exposure to microorganisms.

269 tion by-products (DBPs) are reproductive and developmental toxicants in laboratory animals.

270 nt an approach to understanding differential developmental trajectories among children with BI.

271 ways may direct bHR/bLR rats along divergent developmental trajectories and promote a widely differen

272 derlying mechanisms and understanding varied developmental trajectories associated with disruptive be

273 rovide an in-depth view of the cell types or developmental trajectories in the sample of interest.

274 omics in mice and human samples to delineate developmental trajectories of alphabeta T cell subsets a

275 We identified developmental trajectories of early-life microbiome comp

276 his QTL plus a few other QTLs that determine developmental trajectories of leaf allometry, whose expr

277 s for resolving 52 experimentally determined developmental trajectories.

278 We resolve the developmental trajectory and transcriptional signatures

279 The observed developmental trajectory of affected connections is cons

280 However, the normative developmental trajectory of basal ganglia iron concentra

281 The developmental trajectory of human skeletal myogenesis an

282 Further, we found that the developmental trajectory of R2* in the putamen is signif

283 evelopment yet reported, we characterize the developmental trajectory of tissue iron concentration ac

284 ese cells are connected along a reproducible developmental trajectory: initiated in basal cells exhib

285 ell leukemia factor 1 (PBX1) is an essential developmental transcription factor, mutations in which h

286 sive complex 2 (PRC2) silences expression of developmental transcription factors in pluripotent stem

287 The resulting developmental transcriptome is globally structured by dy

288 DS 79 are essential regulators of early seed developmental transition and impact both seed size and q

289 ontributes to fibre length by modulating the developmental transition from rapid cell elongation to s

290 of pluripotent stem cells and regulates the developmental transition from stem cells to various cell

291 We show that this developmental transition includes the formation of hundr

292 epressive Complexes (PRC1 and PRC2) regulate developmental transitions in plants.

293 works that coordinate defensive measures and developmental transitions in response to environmental c

294 e clusters, and how they are remodelled upon developmental transitions remain poorly understood.

295 will help both to dissect the metabolic and developmental triggers for bolting and to identify poten

296 putrescine that modify the phenotype in this developmental Tsc2-RG model.

297 dent transcriptional network is critical for developmental tumors in children and adolescents carryin

298 lved multiple times from ancestrally plastic developmental variation during adaptation to high temper

299 tly, key transcriptional changes during this developmental window have been characterized in the mode

300 n of reactive oxygen species (ROS) along the developmental zones of the Arabidopsis root.