ライフサイエンスコーパス: developmental abnormality

1 ses, the Wnt3 ablation exhibits the earliest developmental abnormality.

2 eterotopia that might indicate an underlying developmental abnormality.

3 these neurological defects do not rely upon developmental abnormality.

4 craniofacial, extraocular muscle, and ocular developmental abnormalities.

5 pican function is associated with widespread developmental abnormalities.

6 he cause of a genetic syndrome with distinct developmental abnormalities.

7 y in mice and humans, often including severe developmental abnormalities.

8 jury may be an important cause of subsequent developmental abnormalities.

9 ciated with a spectrum of human diseases and developmental abnormalities.

10 une disease but also display morphologic and developmental abnormalities.

11 eizures, sensorineural deafness, ataxia, and developmental abnormalities.

12 of H3K4me have been found to display various developmental abnormalities.

13 Bit1-null mice were born alive but with some developmental abnormalities.

14 nt disorder that is associated with multiple developmental abnormalities.

15 der along with severe cardiac arrhythmia and developmental abnormalities.

16 t different embryonic days due to variegated developmental abnormalities.

17 tract prion diseases, results in no apparent developmental abnormalities.

18 of the adult MB neurons rather than causing developmental abnormalities.

19 developmental genes may underlie a number of developmental abnormalities.

20 a/Delta) mice are viable and have no obvious developmental abnormalities.

21 autosomal dominant disorder with pleomorphic developmental abnormalities.

22 a silenced reporter gene, without conferring developmental abnormalities.

23 eficiency as well as severe neurological and developmental abnormalities.

24 ocyte-targeted deletion of EBF1 exhibited no developmental abnormalities.

25 model to identify factors involved in these developmental abnormalities.

26 ndactyly, renal defects and a range of other developmental abnormalities.

27 enesis is induced by environmental stress or developmental abnormalities.

28 implicated in a number of human diseases and developmental abnormalities.

29 f the actin cytoskeleton causes severe plant developmental abnormalities.

30 pathogenicity factors that cause disease or developmental abnormalities.

31 dactyly, renal defects, and a range of other developmental abnormalities.

32 induces both axis duplication and additional developmental abnormalities.

33 ana histone deacetylase induces a variety of developmental abnormalities.

34 and transcriptomic networks reflected these developmental abnormalities.

35 er characterized by several neurological and developmental abnormalities.

36 turbations in phospholipid content or severe developmental abnormalities.

37 genes lead to melanosomal defects and ocular developmental abnormalities.

38 e epiblast, but causes surprisingly discrete developmental abnormalities.

39 offspring of Pax3-FKHR chimeric mice showed developmental abnormalities.

40 ) with ventricular arrhythmias, and skeletal developmental abnormalities.

41 G51-/- mice were healthy and showed no gross developmental abnormalities.

42 (-/-) mice had normal viability and no gross developmental abnormalities.

43 omas of the gastrointestinal tract and other developmental abnormalities.

44 hat are non-viable and that exhibit distinct developmental abnormalities.

45 order characterized by many neurological and developmental abnormalities.

46 nd devastating ophthalmologic and neurologic developmental abnormalities.

47 to early postnatal lethality without obvious developmental abnormalities.

48 t is involved in both inherited and acquired developmental abnormalities.

49 ntal pollutants modifies the genetic risk of developmental abnormalities.

50 e parameters can lead to a broad spectrum of developmental abnormalities.

51 ll lymphopenia, defective hematopoiesis, and developmental abnormalities.

52 ention strategy for multiple NF1-associcated developmental abnormalities.

53 bvious defects in their adaptive immunity or developmental abnormalities.

54 gies for patients with mutant p63-associated developmental abnormalities.

55 environmental enrichment to ameliorate these developmental abnormalities.

56 ate of associated endocrine, neurologic, and developmental abnormalities.

57 n male (64%) and had more frequent birth and developmental abnormalities (45%) than controls (despite

58 drome (HCS) is characterized by craniofacial developmental abnormalities, acro-osteolysis, and osteop

59 h of the observed cardiac defects represents developmental abnormalities affecting distinct stages of

60 We thus show that a developmental abnormality affecting synapse number and e

61 he mutant allele fuct-2 gave rise to similar developmental abnormalities, although they were milder t

62 in long-range association fibers, (3) severe developmental abnormalities and accelerated aging in cal

63 bility, the onset and progression of cancer, developmental abnormalities and adaptive potential.

64 ycle abnormalities and apoptosis, leading to developmental abnormalities and adult tumorigenesis.

65 matin remodeling function has been linked to developmental abnormalities and aggressive cancers.

66 ve been identified as causes of diseases and developmental abnormalities and as sources of adaptive p

67 DES increases the predisposition to uterine developmental abnormalities and cancer in the daughters

68 characterized by childhood aplastic anemia, developmental abnormalities and cancer predisposition.

69 romatin conformation have been implicated in developmental abnormalities and cancer.

70 activation of the Hedgehog pathway can cause developmental abnormalities and cancers, including medul

71 annotations are essential for understanding developmental abnormalities and cancers, is rarely explo

72 is essential to further our understanding of developmental abnormalities and cancers, which frequentl

73 s null mutant mouse embryos exhibit multiple developmental abnormalities and die before 11.5 days of

74 ater stages of embryogenesis commonly showed developmental abnormalities and died at birth.

75 ising, as defective gene silencing underlies developmental abnormalities and disease.

76 f the Hh pathway underlies a number of human developmental abnormalities and diseases, making it an i

77 Aberrant miRNA expression leads to developmental abnormalities and diseases, such as cardio

78 ll suicide are implicated in a wide range of developmental abnormalities and diseases.

79 tients with CS also display neurological and developmental abnormalities and dramatic premature aging

80 ch into macrophage-based therapies for renal developmental abnormalities and have implications for th

81 r organ systems and is particularly prone to developmental abnormalities and hemorrhage.

82 unction are most likely to contribute to the developmental abnormalities and increased cerebellar cel

83 ere downregulation of EGFR may contribute to developmental abnormalities and lethal phenotype found i

84 ical centrosome aberrations underlie certain developmental abnormalities and may promote cancer.

85 Defects in ciliary function result in developmental abnormalities and multiple ciliopathies.

86 nd perinatal outcomes of 11 neonates who had developmental abnormalities and neurological damage asso

87 provide insights into the molecular basis of developmental abnormalities and pathological cell death

88 oteases, a class of proteins linked to human developmental abnormalities and pathology, may be associ

89 srupting ciliogenesis result in a variety of developmental abnormalities and postnatal disorders.

90 ic disorder characterized by UV sensitivity, developmental abnormalities and premature aging.

91 unction causes pleiotropic effects including developmental abnormalities and reduced cytosine methyla

92 range of genetic conditions characterised by developmental abnormalities and reduced organismal growt

93 ting that altered LTD is not attributable to developmental abnormalities and that Akt is critical for

94 is, loss of GATA-1 function produces complex developmental abnormalities and underlies the pathogenes

95 DARC(-/-) mice lacked developmental abnormalities and were healthy at 1 year.

96 ng NQO2 gene expression showed no detectable developmental abnormalities and were indistinguishable f

97 lid tumors and are found in association with developmental abnormalities and/or mental retardation.

98 ich is characterized by bone marrow failure, developmental abnormalities, and a high incidence of mal

99 xhibited myeloid lineage expansion, lymphoid developmental abnormalities, and a marked decrease of th

100 by osteoporosis and fractures, craniofacial developmental abnormalities, and acro-osteolysis.

101 ions are associated with cognitive deficits, developmental abnormalities, and cancer.

102 o morphological differences between species, developmental abnormalities, and human disease.

103 sorder characterized by psychomotor defects, developmental abnormalities, and leukocyte adhesion defe

104 etic control provides insight into ontogeny, developmental abnormalities, and tissue regeneration.

105 disease in infancy; the presence of comorbid developmental abnormalities; and the possible laminar st

106 CASK KO mice exhibit no major developmental abnormalities apart from a partially penet

107 In 40% of these infants with DBA, diverse developmental abnormalities are also noted.

108 It is unclear whether the developmental abnormalities are caused by a defective At

109 crossed to wild-type plants, the pleiotropic developmental abnormalities are immediately restored in

110 The causes of these late developmental abnormalities are most likely sequential,

111 cancer, the links between defects in NER and developmental abnormalities are not well understood.

112 nd pharmacological studies in which cortical developmental abnormalities are suspected.

113 This causes multiple growth and developmental abnormalities as well as immune system ano

114 of the Hh-Gli pathway has been implicated in developmental abnormalities as well as in several cancer

115 contribute to mutagenesis, oncogenesis, and developmental abnormalities, as well as cellular lethali

116 The developmental abnormalities associated with disruption o

117 out by the albino mutation, despite numerous developmental abnormalities associated with the retinal

118 nding mutant of Helios did not contribute to developmental abnormalities at early times after transpl

119 chromosomal instability in association with developmental abnormalities, bone marrow failure and a s

120 bility disorder associated with a variety of developmental abnormalities, bone marrow failure and pre

121 ing lipid phosphatase activity cause similar developmental abnormalities but distinct tumor spectra w

122 Smad4 in the epiblast results not in global developmental abnormalities but instead in restricted pa

123 he expected Mendelian ratio without apparent developmental abnormalities but susceptible to neonatal

124 The severity of numerous developmental abnormalities can vary widely despite shar

125 l death processes is likely to contribute to developmental abnormalities, cancer, aging, inflammation

126 We identified a family where ocular developmental abnormalities (cataract, anterior segment

127 f sexual development rescues both growth and developmental abnormalities caused by Delta gprD, sugges

128 re complete picture of the severe damage and developmental abnormalities caused by ZIKV infection tha

129 ng disorder associated with neurological and developmental abnormalities, caused by mutations mainly

130 lele and a Notch2 hypomorphic allele exhibit developmental abnormalities characteristic of Alagille s

131 phatase RSG1 die at embryonic day 12.5, with developmental abnormalities characteristic of decreased

132 ly non-viable and survivors exhibit multiple developmental abnormalities characterized by cellular ex

133 h as transverse hemimelia (TH), a congenital developmental abnormality characterized by absence of a

134 by the induction of disease symptoms such as developmental abnormalities, chlorosis, and necrosis.

135 cial-cutaneous syndromes are associated with developmental abnormalities, cognitive deficits, and aut

136 Human organogenesis is when severe developmental abnormalities commonly originate.

137 nal can have different etiologies, including developmental abnormality, congenital defect, chronic ot

138 ES RNA on Xenopus embryogenesis and observed developmental abnormalities consistent with impaired Wnt

139 Morphant embryos had developmental abnormalities consistent with PMM2-CDG pat

140 The resulting animals exhibited no obvious developmental abnormality, contained normal numbers of g

141 T(mRID) mice are viable and exhibit no gross developmental abnormalities, demonstrating that the repo

142 ic gene alterations can increase the risk of developmental abnormalities driven by environmental poll

143 order, leading to characteristic multi-organ developmental abnormalities, dysmorphic facies, limb mal

144 Individuals with FA are at high risk of developmental abnormalities, early bone marrow failure a

145 repression, rmr mutant plants have no gross developmental abnormalities even after several generatio

146 Later, these developmental abnormalities evolve toward neoplastic tra

147 xpression of KGF in the lung without causing developmental abnormalities from leaky KGF expression.

148 Lgi1 null mutant mice show no gross overall developmental abnormalities from routine histopathologic

149 abdominal organ rupture, which may stem from developmental abnormalities given the prominent role of

150 n B12-deficient mother is at risk for severe developmental abnormalities, growth failure, and anemia.

151 of DNA from human tumors or individuals with developmental abnormalities has led to the discovery of

152 mice and have shown that these mice display developmental abnormalities, hypoplastic retinas, and pr

153 rially or obliquely derived blastomeres show developmental abnormalities in both late preimplantation

154 Developmental abnormalities in endocardial cushions freq

155 We also describe developmental abnormalities in Eomes/Nodal double hetero

156 in part, for the characteristic cellular and developmental abnormalities in FA.

157 cellular origins and molecular mechanisms of developmental abnormalities in FOXF1-deficient mice and

158 o test endocrine disrupting chemical-induced developmental abnormalities in human endocrine tissues.

159 g white matter fiber tracts in patients: (1) developmental abnormalities in limbic fibers, (2) accele

160 s extensive remodeling, similar in extent to developmental abnormalities in mice lacking some TNF fam

161 dings provide evidence of ERK dysregulation, developmental abnormalities in neurogenesis, and behavio

162 ective olfaction, which is likely related to developmental abnormalities in olfactory bulb and/or cer

163 u-80, or lig-4 NHEJ genes displayed multiple developmental abnormalities in response to radiation-ind

164 Overmigration involves multiple developmental abnormalities in the brain surface basemen

165 tiple visual problems arise due to damage or developmental abnormalities in the cortex of the brain.

166 The developmental abnormalities in the Dax1-deficient testis

167 Developmental abnormalities in the eye included laminati

168 dies to folate receptor, results in profound developmental abnormalities in the fetus, ranging from n

169 ates in these systems could be attributed to developmental abnormalities in the immune systems of Lt

170 majority of laminin chains lead to specific developmental abnormalities in the kidney, Lama4-/- mice

171 unrestricted feeding results in a variety of developmental abnormalities in the reproductive system,

172 Crumbs protein complex, the latter implying developmental abnormalities in the retina.

173 netically influenced and connection-specific developmental abnormalities in the schizophrenia connect

174 reduced responsiveness was not due to subtle developmental abnormalities in the TP-deficient mice.

175 kdm6a and kdm6al, we analyzed morphants for developmental abnormalities in tissues that are affected

176 in vivo This work describes early postnatal developmental abnormalities in visual and olfactory sens

177 ey have been shown to cause reproductive and developmental abnormalities in wildlife and plants and h

178 lpting retinal development but also that the developmental abnormality in Cfh(-/-) likely establishes

179 th (hypodontia and oligodontia) are a common developmental abnormality in humans and heterozygous mut

180 y exogenous GM-CSF, indicating the lack of a developmental abnormality in the epithelial cell prolife

181 ce of functional obstruction, resulting from developmental abnormality, in causing congenital obstruc

182 Other developmental abnormalities include overriding aorta, ve

183 n of CHB2 expression resulted in pleiotropic developmental abnormalities including abnormal seedling

184 rgrowth syndrome with a number of associated developmental abnormalities including congenital heart d

185 We show that Asxl1 deletion in mice led to developmental abnormalities including dwarfism, anophtha

186 autosomal dominant disorder with pleomorphic developmental abnormalities including lentigines, cardia

187 tions in ADAMTS18 are associated with ocular developmental abnormalities including microcornea, ectop

188 e been generated; these mice exhibit notable developmental abnormalities including microtia, with cra

189 Syndrome, which is characterized by multiple developmental abnormalities including polysyndactyly and

190 utations in ATRX give rise to characteristic developmental abnormalities including severe mental reta

191 n, decreased survival, decreased ploidy, and developmental abnormalities, including abnormal extracel

192 nic Arabidopsis plants generated pleiotropic developmental abnormalities, including abnormal leaves,

193 w that constitutive loss of Asxl1 results in developmental abnormalities, including anophthalmia, mic

194 is sufficient to elicit an array of striatal developmental abnormalities, including decreased anatomi

195 lation profiles were associated with various developmental abnormalities, including early senescence,

196 osensitivity, CS patients suffer from severe developmental abnormalities, including growth retardatio

197 ctor forkhead box P2 (FOXP2) result in brain developmental abnormalities, including reduced gray matt

198 are viable but display a number of specific developmental abnormalities, including some that resembl

199 t spastic Han-Wistar rats (sHW) that display developmental abnormalities, including spastic paresis,

200 1 gene is recessive and pleiotropic, causing developmental abnormalities, increasing sensitivity to a

201 mutations in ciliary genes lead to bile duct developmental abnormalities is not understood.

202 e role of ARX in the observed behavioral and developmental abnormalities is unclear.

203 The reason for this developmental abnormality is apparent as early as embryo

204 However, this developmental abnormality is not recapitulated in mice l

205 ecause psychiatric diseases may originate in developmental abnormalities, it is crucial to investigat

206 s are associated with a large class of human developmental abnormalities, known as RASopathies, that

207 These early developmental abnormalities lead, in adults, to signific

208 s with a recombinant sex chromosome we found developmental abnormalities leading to 1:2 sex biases, c

209 line mutations of KRAS and HRAS cause severe developmental abnormalities leading to Noonan, cardio-fa

210 ignaling is linked to cancer progression and developmental abnormalities, making identification of me

211 lineages, female virgin mice display mammary developmental abnormalities, mammary intraepithelial neo

212 responsible for heterochromatic splaying and developmental abnormalities maps to chromosome 8p21.

213 However, recent reports suggest that developmental abnormalities may also be important in HGP

214 iac specification, suggesting that embryonic developmental abnormalities may be attributable to extra

215 nt early onset, raising the possibility that developmental abnormalities may be involved in its patho

216 ey are systemically smaller, suggesting that developmental abnormalities may extend further than thei

217 We propose that these HD-associated developmental abnormalities might compromise neuronal ho

218 F1) reduces normal Hsp83 levels and promotes developmental abnormalities, mimicking the spectrum of p

219 etic CP not due to postnatal brain injury or developmental abnormalities (n = 109).

220 Here, we report that three germ cell developmental abnormalities, namely continued proliferat

221 viable and fertile and showed neither gross developmental abnormality nor immune dysfunction.

222 Patients also display significant developmental abnormalities not seen in p110delta knocko

223 ity in a later generation, suggests that the developmental abnormalities observed are a consequence o

224 Developmental abnormalities observed in Cornelia de Lang

225 ortholog fully recapitulates the spectrum of developmental abnormalities observed in the human syndro

226 nd Hid was probably the underlying cause for developmental abnormalities observed upon dElys depletio

227 transport, which may contribute to the other developmental abnormalities observed.

228 These developmental abnormalities occur as a result of haplo-i

229 However, developmental abnormalities occur in the bacterium and t

230 Developmental abnormalities of anterior paralimbic and h

231 the skin or hair, epidermal hyperplasia, or developmental abnormalities of basal or suprabasal epide

232 ors to stimulation of adenylyl cyclase cause developmental abnormalities of bone, as well as hormone

233 d genes resulting in embryonic lethality and developmental abnormalities of both embryo and placenta.

234 report that Apc-deficient zebrafish display developmental abnormalities of both the lens and retina.

235 Developmental abnormalities of craniofacial structures a

236 Developmental abnormalities of myelination are observed

237 Developmental abnormalities of neuronal process formatio

238 ssive neurogenetic disorder characterized by developmental abnormalities of the brain and impaired ne

239 1q42-q44 have been reported in a variety of developmental abnormalities of the brain, including micr

240 ency in mice induces hyperphagic obesity and developmental abnormalities of the brain.

241 central nervous system were: schizencephaly, developmental abnormalities of the corpus callosum, arac

242 We observed that developmental abnormalities of the cranial base synchond

243 utosomal recessive disorder characterized by developmental abnormalities of the eye and central nervo

244 ular hypopigmentation associated with common developmental abnormalities of the eye.

245 l-dominant disorder that is characterized by developmental abnormalities of the face, eyes, teeth, an

246 Developmental abnormalities of the heart have also been

247 In addition, genetic factors and developmental abnormalities of the hippocampus may both

248 Developmental abnormalities of the ocular anterior segme

249 Some developmental abnormalities of the pupae and emerging mo

250 There are also developmental abnormalities of the salivary glands, inne

251 rked cardiac conduction defects coupled with developmental abnormalities of the VCS.

252 ion of the eyes, altered morphology of ears, developmental abnormality of fin muscle, disorganization

253 infant death syndrome (SIDS) results from a developmental abnormality of medullary serotonergic neur

254 ogic defects in Holt-Oram syndrome reflect a developmental abnormality of the conduction system.

255 se findings are consistent with NCMD being a developmental abnormality of the macula.

256 tly resulted in periventricular heterotopia, developmental abnormalities often associated with mutati

257 opportunity to examine the effects of these developmental abnormalities on adult fitness and heart f

258 The sarcolipin-null mice do not show any developmental abnormalities or any cardiac pathology.

259 he results of such screens may be limited by developmental abnormalities or lethality associated with

260 on sensitivity of normal human astrocytes or developmental abnormalities or lethality of irradiated Z

261 ditions such as lysosomal storage disorders, developmental abnormalities, or cancer.

262 ndocrine disorder and is primarily caused by developmental abnormalities otherwise known as thyroid d

263 es of PPCD, has implicated TCF8 mutations in developmental abnormalities outside the eye, and has pre

264 We previously showed that one of the developmental abnormalities present in an antisense-METH

265 Both usb1-depleted embryos displayed developmental abnormalities recapitulating the signs of

266 ations have moderate renal collecting-system developmental abnormalities relative to beta1-null mice.

267 upted both HS and CS biosynthesis and caused developmental abnormalities reminiscent of GAG biosynthe

268 fertile without the growth, neurological or developmental abnormalities reported in Csf1r(-/-) roden

269 y in ze-brafish results in hematopoietic and developmental abnormalities resembling DBA.

270 rus-induced disease symptoms often result in developmental abnormalities resembling perturbation of m

271 nts is related to NE function, as opposed to developmental abnormalities resulting from chronic NE de

272 2019) show that, in Drosophila melanogaster, developmental abnormalities resulting from loss of repre

273 s recapitulate many (and perhaps all) of the developmental abnormalities seen in human patients with

274 disease and infer that the constellation of developmental abnormalities seen in Noonan syndrome spec

275 ressing cells recapitulate the hematopoietic developmental abnormalities seen in the bone marrow of h

276 in (CREB)-binding protein (CBP) show several developmental abnormalities similar to patients with Rub

277 These CnB mutant mice exhibit vascular developmental abnormalities similar to the NFATc3/c4 nul

278 TS splice junction lead to severe urogenital developmental abnormalities such as Frasier syndrome, in

279 lation of telomerase has often been found in developmental abnormalities, such as cancer, loss of fun

280 early-onset glaucomas may arise secondary to developmental abnormalities, such as glaucomas that occu

281 s often include leaf malformations and other developmental abnormalities, suggesting that viruses can

282 Virus-infected plants often display developmental abnormalities that include stunting, leaf

283 Amblyopia is a developmental abnormality that results in physiological

284 but frequently results in stunted growth and developmental abnormalities, the mechanisms of which are

285 ccumulation of high levels of LCB/LCB-Ps and developmental abnormalities, the sphingolipid profiles o

286 Although ALS2(-/-) mice lacked obvious developmental abnormalities, they exhibited age-dependen

287 ispair in native CRE resulted in substantial developmental abnormalities, thus confirming the danger

288 ith autism spectrum disorder (ASD) and other developmental abnormalities to construct a genome-wide m

289 ggested that the pathogenesis of the cardiac developmental abnormalities was related to node developm

290 This developmental abnormality was accounted for by failed ac

291 96h EC(50) estimates based on frequencies of developmental abnormalities were 2.1, 2.6, and 14.2 mg/L

292 n efflux inhibitors and exogenous auxin, and developmental abnormalities were documented.

293 Multiple developmental abnormalities were found, including infert

294 similar to those of wild-type plants, and no developmental abnormalities were observed.

295 ay, LA, also resulted in increased CYP1A and developmental abnormalities when exposed to sediments co

296 s encoding catalytic mutants manifest subtle developmental abnormalities when subjected to temperatur

297 station and exhibit similar, but less severe developmental abnormalities, whereas transheterozygous B

298 ed levels of histone acetylation and similar developmental abnormalities, which are heritable in the

299 with spastic or dyskinetic CP not caused by developmental abnormalities who had a neonatal blood spe

300 the same genes as XP, but they have primary developmental abnormalities without an increase in skin