ライフサイエンスコーパス: developmentally

1 ession of TEs and found them to be regulated developmentally.

2 somes is regulated during the cell cycle and developmentally.

3 Setting aside the developmentally abnormal Kebara 2 vertebral column, La C

4 PSCs, conventional human iPSCs are in a more developmentally advanced state called primed pluripotenc

5 however, is the regression so extreme that a developmentally advanced young child would lose almost a

6 er Eye Splicer, to facilitate exploration of developmentally altered splicing events and to improve u

7 dolescents to ensure service development are developmentally and culturally appropriate.

8 expanded the range of organisms we can study developmentally and deepened what we can learn.

9 de a mechanism to explain the coevolution of developmentally and functionally integrated craniofacial

10 er, these proteins may all be regulated both developmentally and functionally, restricting their util

11 Brain sex differences are established developmentally and generate enduring changes in circuit

12 ophrenia to identify increased expression of developmentally and genetically regulated isoforms in th

13 to transiently suppress a sexual dimorphism, developmentally and in response to nutritional stress.

14 celerated behavioral recovery and innervated developmentally appropriate forebrain targets, whereas L

15 We used developmentally appropriate standard questionnaires, int

16 t intervention packages should be applied at developmentally appropriate times during the life course

17 ucational and vocational needs of AYA in the developmentally appropriate way.

18 in at hatching possesses a large fraction of developmentally arrested neurons with a small soma, hete

19 hese parasites persist in the environment as developmentally arrested third-stage infective larvae (i

20 idence that some retrotransposons may evolve developmentally associated escape strategies to overcome

21 found to be enriched at the promoters of the developmentally associated genes.

22 Developmentally, between P7 and P14, DUSP5 expression in

23 race AMFs, we demonstrate that most AMFs are developmentally cleared during alveologenesis.

24 closely resembling those of blastocysts from developmentally competent oocytes.

25 be linked, antigen switching being higher in developmentally competent, fly-transmissible, parasites

26 er, only a fraction of reprogrammed PSCs are developmentally competent.

27 CTD code that may augment gene regulation in developmentally complex organisms.

28 T1/3IFN response capacity appears strongly developmentally constrained at birth.

29 xpected to be phylogenetically conserved and developmentally constrained at broad phylogenetic scales

30 ponses suggest that plasticity itself may be developmentally constrained, though rigorously testing t

31 yers in multiple autoimmune diseases and are developmentally contingent on reciprocal functionality b

32 we detected distinct folding patterns at the developmentally controlled beta-globin locus.

33 ate their effects on Z-ring stability during developmentally controlled cell division via a network o

34 Developmentally controlled expression of two Polycomb re

35 to understand how organelle morphogenesis is developmentally controlled in a system where regulators

36 NMD is regulated in a tissue-specific and developmentally controlled manner, raising the possibili

37 LRs are generated either via a developmentally controlled mechanism or through inductio

38 In summary, developmentally controlled mitophagy promotes a metaboli

39 We identify developmentally controlled modulations in perivitelline

40 These results corroborate complex developmentally controlled ompA expression in C. trachom

41 ides functional evidence that the 3'RR has a developmentally controlled potential to constitutively a

42 is, but not for the well-established form of developmentally controlled programmed cell death.

43 Central to this mechanism is the developmentally controlled transcription of an alternate

44 This asymmetric localization was not developmentally controlled, but resulted from sustained

45 is important to know what factors drive this developmentally critical behavioral output.

46 ory connectivity in a network that governs a developmentally critical behavioral sequence in Drosophi

47 lo's moral psychology of obligation would be developmentally deepened by greater attention to early e

48 ction, we deleted the entire pxr gene from a developmentally defective strain that fails to remove Px

49 to how PGCs exposed to DNA damage can become developmentally defective, leaving only those geneticall

50 of studies have now started to connect these developmentally defined populations with their roles in

51 vation of adult-born neurons, revealing that developmentally defined sets of neurons may differential

52 ntrols, VHL knockout kidneys are smaller and developmentally delayed by postnatal day 1, and have abo

53 ypically developing children; and 22 matched developmentally delayed children.

54 ypically developing children; and 22 matched developmentally delayed children.

55 ly MZT, undergo cell-cycle pause, and remain developmentally delayed throughout larval life.

56 We previously showed that hif-1 mutants are developmentally delayed when grown under iron limitation

57 ected individuals had short stature and were developmentally delayed.

58 ic, and specific polarization in response to developmentally deployed cues.

59 gs establish a regulatory system controlling developmentally deposited suberin, which likely differs

60 Nevertheless, the presence of a developmentally derived beta-cell heterogeneity is uncle

61 le shell, the carapace and the plastron, are developmentally different entities.

62 Here we have engineered and developmentally differentiated NKX2-1GFP reporter plurip

63 We find that fiber cells from spatially and developmentally discrete regions of the transgenic (cata

64 Here we report a developmentally distinct expression and function of CB1R

65 ells in the ventral pallium; it is therefore developmentally distinct from the Nr4a2-postive dorsal e

66 In cells in which two developmentally distinct LCR-regulated globin genes are

67 d modality-specific, but the significance of developmentally distinct neuronal populations remains un

68 ) is regulated by the neighboring hindgut, a developmentally distinct organ.

69 eral miscanthus genotypes harvested at three developmentally distinct time points.

70 bout how the flower is partitioned into four developmentally distinct whorls.

71 tin ligase neuronal precursor cell-expressed developmentally down-regulated 4-1 (NEDD4-1).

72 hat removes neural precursor cell-expressed, developmentally down-regulated 8 (NEDD8) moieties from c

73 ike protein neural precursor cell expressed, developmentally down-regulated 8 (NEDD8) to the cullin s

74 se, NEDD4-1 (neural precursor cell-expressed developmentally down-regulated protein 4).

75 ) or NEDD8 (neural precursor cell expressed, developmentally downregulated 8).

76 We show here that it is a developmentally downregulated but dynamic component of K

77 and Nedd4l (neural precursor cell expressed developmentally downregulated gene 4-like; chromosome 18

78 sA201, NEDD (neural precursor cell expressed developmentally downregulated protein) 4-1, but not its

79 gates Nedd8 (neural precursor cell expressed developmentally downregulated) to specific targets, is a

80 in genomic regions with cell type-specific, developmentally dynamic DNAm patterns.

81 contrast to the individual single knockouts, developmentally early conditional double knockout of bot

82 Strikingly, developmentally early conditional knockout of cerebellin

83 lly redundant candidate genes, we identified developmentally early expression of another synaptic neu

84 nfested seeds as well as among seeds hosting developmentally early or late-stage larvae with high acc

85 d the spontaneous reacquisition of a latent, developmentally encoded epigenetic landscape.

86 Developmentally, environmental manipulation of OL progen

87 CC to ethylene), and ethylene evolution were developmentally, environmentally, and tissue-specificall

88 rogeneity in the behavior of genetically and developmentally equivalent cells is becoming increasingl

89 We show that fetal lambs that are developmentally equivalent to the extreme premature huma

90 Histone H3.3 is a developmentally essential variant encoded by two indepen

91 confirmed that CD4(+) T cells from infected developmentally exposed offspring exhibit reduced prolif

92 Zebrafish were developmentally exposed to 4,8-dioxa-3H-perfluorononanoa

93 We found that IL-4 and IL-13 engage a developmentally expressed IL-4Ralpha/IL-13Ralpha1 hetero

94 hat the RNA-binding protein LIN28B, which is developmentally expressed in a pattern reciprocal to tha

95 ultures and in vivo We found that ZSCAN21 is developmentally expressed in neurons in different rat br

96 In this study, we show that the developmentally expressed protein encoded by Lia3-Like 1

97 These changes involved both developmentally fixed and plastic changes in gene expres

98 Such data will complement adult and developmentally focused HCA projects to provide a rich c

99 cal component of executive function, expands developmentally from childhood through adulthood.

100 vy-chain variable region exons are assembled developmentally from V, D, J gene segments.

101 Developmentally, GATA-binding protein-2 (GATA-2) was exp

102 ial context to exert a dominant influence on developmentally hard-wired hypothalamus-mediated male te

103 -) and FIX(-/-) mice, but not VWF(-/-) mice, developmentally have an osteoporotic phenotype.

104 Developmentally, high neo-natal adiposity and preferenti

105 tem cell (hPSC) derived tissues often remain developmentally immature in vitro, and become more adult

106 d purify these cells as they first emerge as developmentally immature NKX2-1(GFP+) lung progenitors a

107 ore probable and feasible via reversion to a developmentally immature state.

108 repertoire that facilitates morphogenesis of developmentally immature young.

109 covers an association of male fertility with developmentally impactful RNAs in 2-4 cell embryos.

110 on lipopolysaccharide stimulation were more developmentally impaired as assessed by the Mullen Scale

111 ter phytohemagglutinin stimulation were more developmentally impaired as measured by the Mullen Scale

112 Here, we identify a developmentally impaired endocardial population in HLHS

113 amygdala (BLA) perineuronal nets, which are developmentally implicated in extinction.

114 rmissive epigenetic landscape at a subset of developmentally important bivalent promoters characteriz

115 ts should build a foundation for identifying developmentally important genes, especially those regula

116 ensure proper spatio-temporal activation of developmentally important genes.

117 associated with transcriptional silencing of developmentally important genes.

118 ption factors and regulate the expression of developmentally important genes.

119 ly distinct, stable across cell division and developmentally important in directing the Ig repertoire

120 TF binding specificity and reveals that many developmentally important proteins display preference fo

121 Our results suggest a developmentally important role for Syt2a in maturing syn

122 we tested the hypothesis that overexpressing developmentally important transcription factors in adult

123 We applied PRISM to resolve two developmentally important, but contentious, lineages-Shh

124 th functionally specialized subsets that are developmentally imprinted and modulated by local tissue

125 However, how flexible behavior changes developmentally in ASD remains largely unknown.

126 tyrosine kinase, which is tightly regulated developmentally in rodents and primates, and exhibits re

127 sing defects that cause higher percentage of developmentally incompetent oocytes after EXOSC10 deplet

128 ochondrial volumes and synaptic localization developmentally increase to support high firing rates re

129 hat the expression level of Nogo-A in the OB developmentally increased during axonal collateral forma

130 that PcG targets coalesce in vivo, and that developmentally induced expression of one of the target

131 suggest that many RDCs present in NSPCs are developmentally influenced to occur in this cell type an

132 ly, confirming several features predicted by developmentally informed models of feather evolution [4-

133 The Head Start REDI (Research-Based, Developmentally Informed) intervention was used to enric

134 rrier functionality was accomplished using a developmentally-inspired induction protocol that include

135 tem cells (GSCs) to be quiescent or progress developmentally is regulated differently from the non-go

136 Similarly, silencing GSK3 in nephrocytes is developmentally lethal for this cell.

137 orth a social plasticity model that includes developmentally limited enhanced social attunement (ie,

138 Developmentally, males are exposed to high levels of tes

139 ate co-transmission and that this pathway is developmentally malleable, with high serotonin levels du

140 two mouse stains: one that deletes Podxl in developmentally mature podocytes (Podxl(DeltaPod)) and a

141 Because developmentally matured B cells undergo biologically pro

142 ding on recent studies supporting a role for developmentally moderated regulatory genomic variation i

143 he protein or whether pioneering activity is developmentally modulated, we studied the highly conserv

144 Developmentally, naked mole rats showed reduced and prol

145 e at the organelle level through a series of developmentally orchestrated mitochondrial processes.

146 ssing in the amygdala has been implicated in developmentally originating neuropsychiatric disorders.

147 F2 generation descendants of mice that were developmentally overexposed to thyroid hormone due to a

148 e we show that Hox11 paralogous genes, which developmentally pattern the zeugopod (radius/ulna and ti

149 y not reliably map to cellular phenotypes in developmentally perturbed systems.

150 Developmentally, Pitx2 regulates formation of the Sox2(+

151 fic to for pr1 neurons in the VNC, guiding a developmentally plastic escape response circuit.

152 solated from murine lymphoid tissue retained developmentally plastic phenotypic and epigenetic profil

153 and the relative contribution of genetic and developmentally plastic responses to environmental chang

154 before injury, which is normally observed in developmentally poised enhancers.

155 1-deficient cells induce lineage-appropriate developmentally poised genes poorly while lineage-inappr

156 and a reference site; b) test the ability of developmentally precocious estrogen exposure to recapitu

157 xr to prevent fruiting body development by a developmentally proficient wild-type strain under high-n

158 ccessibility across autosomes was pervasive, developmentally programmed and composed of several patte

159 nd intra-depot differences in adipocytes are developmentally programmed and contribute to the wide ra

160 have shown that metabolism and autophagy are developmentally programmed and essential for neutrophil

161 idual susceptibility to allergic diseases is developmentally programmed by early-life exposures.

162 division and cortical granule exocytosis, in developmentally programmed cell death when the predomina

163 h lateral inter-clonal input may represent a developmentally programmed connectivity motif supporting

164 work establishes the molecular mechanism of developmentally programmed crinophagy in Drosophila and

165 re we show that TEX19.1, which is induced by developmentally programmed DNA hypomethylation, can dire

166 Developmentally programmed genome rearrangement accompan

167 enetics in multigenerational transmission of developmentally programmed obesity and associated cardio

168 is shown to involve a remarkable variety of developmentally programmed phenomena such as genome edit

169 ract to influence neural circuits underlying developmentally programmed social interactions such as m

170 tivity stimulate C. crescentus to bypass its developmentally programmed temporal delay in cell differ

171 elanogaster macrophages is involved in their developmentally programmed tissue invasion.

172 ntiation, gammadelta T cells instead can be 'developmentally programmed' in the thymus to generate di

173 Here, we provide evidence that developmentally programmed, temporal changes in chromati

174 These differences could be attributable to developmentally-programmed local branching for larger ve

175 1 levels are highest and Ca(V)2.2 levels are developmentally reduced.

176 s of meiosis and demonstrates that cells can developmentally regulate tethering to induce organelle r

177 ulated indices for functional pairs that are developmentally regulated (GluA2:GluN1; GluN2A:GluN2B),

178 a transfer-DNA insertional mutants using the developmentally regulated ABSCISIC ACID INSENSITIVE3 (AB

179 This developmentally regulated acetylation event critically g

180 22-1133) demonstrate severe dysregulation of developmentally regulated alternative splicing and polya

181 SNAP-25 exists as two developmentally regulated alternatively spliced isoforms

182 rodent brain, astrocyte mGluR5 expression is developmentally regulated and confined in expression/fun

183 Replication timing is developmentally regulated and correlated with chromatin

184 man mPFC-amygdala functional connectivity is developmentally regulated and figures prominently in num

185 hat communication via connexins in the CC is developmentally regulated and may play a part in the rea

186 We show that MAP7 expression is developmentally regulated and perturbation of this expre

187 evel in Xenopus embryos shows that H2Bub1 is developmentally regulated and requires Rnf20.

188 lts suggest that PRC2-dependent silencing is developmentally regulated by accessory proteins that eit

189 Both are developmentally regulated by the inflammatory prostaglan

190 findings support the idea that disruption of developmentally regulated calcium channel splicing patte

191 Our findings highlight developmentally regulated changes in mitotic behaviour t

192 planar cell polarity (PCP) effectors and in developmentally regulated cilium formation [13, 14], con

193 (mPFC) and amygdala plays important roles in developmentally regulated cognitive and emotional proces

194 07E (Kcc2(E/E) ), which prevented the normal developmentally regulated dephosphorylation of these sit

195 turation depends on release of inhibition by developmentally regulated diffusible signals from the re

196 vitro to assess the mechanisms and timing of developmentally regulated edited mRNA expression.

197 complex recently linked to the silencing of developmentally regulated endogenous retrovirus elements

198 ding on recent studies supporting a role for developmentally regulated epigenetic variation in the mo

199 e ZmBCH2 gene has an endosperm-preferred and developmentally regulated expression profile, but the de

200 and modifies KAR gating in DRG neurons in a developmentally regulated fashion in mice.

201 ic knockout of NRF2 demonstrates its role in developmentally regulated gamma-globin gene expression a

202 IGFBP2 is a developmentally regulated gene that is highly expressed

203 families and >70 functional groups contained developmentally regulated genes from five to six species

204 od of estimating the position of TADs around developmentally regulated genes in genomes where chromat

205 heterogeneity combined with the activity of developmentally regulated genes suggests multiple mechan

206 We observed differences in developmentally regulated genes, as well as variation in

207 nabled new statistical tests for identifying developmentally regulated genes.

208 t by indirectly supporting the repression of developmentally regulated genes.

209 However, whether the developmentally regulated GluN3A subunit also modulates

210 xpression signature shared between different developmentally regulated growth processes and responses

211 to proper ciliogenesis, interacts with Drg1 (developmentally regulated GTP-binding protein 1).

212 cultative heterochromatin (fHC) concerns the developmentally regulated heterochromatinization of diff

213 OsbZIP48 protein levels are developmentally regulated in rice.

214 Comparing two developmentally regulated isoforms of CD45, the larger R

215 t tethering of BbpA is partly dependent on a developmentally regulated L,D-transpeptidase (Ldt).

216 The extent to which developmentally regulated lncRNAs are translated and whe

217 This work establishes rDNA as developmentally regulated loci that receive direct input

218 acts as an architectural protein to connect developmentally regulated looping interactions; the loca

219 found that meso-zeaxanthin is produced in a developmentally regulated manner in chicken embryonic re

220 Developmentally regulated mutagenesis indicates that TAZ

221 synapse pruning and identify a novel role of developmentally regulated neuronal PS exposure that is c

222 nd healing is capable of recapitulating this developmentally regulated organization pattern.

223 Here, we identified M. truncatula DEVELOPMENTALLY REGULATED PLASMA MEMBRANE POLYPEPTIDE (D

224 Programmed DNA elimination is a developmentally regulated process leading to the reprodu

225 When ARGOS8 expression was controlled by the developmentally regulated promoter FTM1, which conferred

226 Some neurites undergo stereotyped and developmentally regulated pruning.

227 Here, we report the developmentally regulated release of the peptide amidati

228 e, we test the hypothesis that disruption of developmentally regulated RNA alternative processing pat

229 specific enhancer units and propose that the developmentally regulated silencing of ESRRB triggers th

230 zation of the sleep-active RIS neuron during developmentally regulated sleep, also known as lethargus

231 To assess the effects of drought stress on developmentally regulated splicing in maize (Zea mays),

232 Our studies suggest that developmentally regulated splicing of tcf7l2 can influen

233 tions at disease-associated cis-elements and developmentally regulated super-enhancers reveals spatia

234 ong arm of Chromosome 4 underwent a dramatic developmentally regulated switch to late replication dur

235 Through developmentally regulated targeted mutagenesis, we demon

236 urons initially focused on the expression of developmentally regulated transcription factors and neur

237 progenitor cells, suggesting a model whereby developmentally regulated transcription factors protect

238 ly identified nine murine lincRNAs that have developmentally regulated transcriptional and epigenomic

239 ng cancer metastasis model, we show that the developmentally regulated transcriptional repressor Capi

240 Our work uncovers an instructive role of a developmentally regulated tubulin isotype in progenitor

241 ed by microglia in immature mouse and human, developmentally regulated, and modulated by inflammation

242 with this, we observed that a Type II NAD is developmentally regulated, and present in MEFs but not i

243 only challenges the dogma that Cox-1 is only developmentally regulated, but also demonstrates a novel

244 uencing, we demonstrate that m(6)A is highly developmentally regulated, exceeding m(6)A levels known

245 own that the number of ORDs in the retina is developmentally regulated, little is known about the mor

246 iming of cell division is both invariant and developmentally regulated, yet how the cell cycle is con

247 results from random stochastic events or is developmentally regulated.

248 ontrol GABAergic interneuron survival during developmentally-regulated cell death.

249 competent to undergo apoptosis, even though developmentally-regulated DrICE function rarely kills tr

250 ion, there has been success in reprogramming developmentally related cell types into beta cells.

251 Mast cells and basophils are developmentally related cells whose activation is a hall

252 signaling pathways) by hyper-methylation of developmentally related genes, which further induced the

253 sets that were metabolically divergent, were developmentally related, and expressed CXCL13, which we

254 ned conditions as they mature in response to developmentally relevant cues, and it provides a framewo

255 binding protein Musashi1 (Msi1) can regulate developmentally relevant genes.

256 requires us to quantitatively understand how developmentally relevant signaling information is active

257 ckout of Chd4 strengthens interactions among developmentally repressed contact domains as well as gen

258 er-enriched fibroblastic reticular cells, is developmentally required for T(FR) cell generation.

259 e the transcription for highly expressed and developmentally required genes, lead to the formation of

260 first-trimester human embryos, identifying a developmentally restricted CD19(-)IL-7R(+) progenitor co

261 Here we define a developmentally restricted engagement of inhibitory circ

262 Our findings identify a developmentally restricted pathogenic mechanism of VPA a

263 nactivation of either the ligand or receptor developmentally resulted in a profound hearing loss at y

264 Using a developmentally sensitive design, the authors investigat

265 reatments remain costly, time intensive, and developmentally sensitive for efficacy.

266 Developmentally sensitive measures of vision-related qua

267 Developmentally sensitive pathophysiological models are

268 Findings provide evidence for a developmentally sensitive period whereby subcortical str

269 of higher protein intake, especially during developmentally sensitive periods, are poorly understood

270 To investigate whether NMN can impact developmentally-set metabolic deficits, we compared trea

271 epigenetic reprogramming and derepression of developmentally silenced genes.

272 polymorphisms that differ between active and developmentally silenced rRNA gene subtypes.

273 The developmentally silenced SIX proteins are reactivated in

274 n in the newborn mouse in which the brain is developmentally similar to a second-trimester human fetu

275 or the evolution of molar complexity that is developmentally simple, where only small-scale developme

276 However, the individual importance of developmentally specific lincRNAs is yet to be establish

277 in post-mitotic neuronal fate, and reveals a developmentally specific role for a broadly expressed in

278 represent discrete lineages, genetically and developmentally specified sets of cells derived from com

279 cts, we select female gametic cells that are developmentally stable and void of endoreduplication.

280 fficient = 0.29, 95% CI = [0.11, 0.48]), was developmentally stable by age 18.

281 Results revealed a developmentally stable modular architecture that anchore

282 specific neurons that remain in an immature, developmentally stalled state until pupation.

283 e and glutathione; (3) inhibition of several developmentally stereotypical energetic and metabolic tr

284 ic sustained and transient interactions with developmentally supportive stromal cells, and that the r

285 be differentiated in vitro by coculture with developmentally supportive stromal cells.

286 Cotton fiber cells are developmentally synchronous, highly elongated, and conta

287 Developmentally, this organ arises as a result of a comp

288 Intrigued by the developmentally timed exchange of SIN3 isoforms, we exam

289 sm by which axons restrict their translatome developmentally to achieve proper targeting.

290 nic neuron identity and suggest that it acts developmentally to program body weight homeostasis.

291 nic neuron identity and suggest that it acts developmentally to program body weight homeostasis.

292 ity and that Pappaa-IGF1 signaling acts post-developmentally to support hair cell survival.

293 ture, exposure to the same patterns led to a developmentally-typical increase in direction selectivit

294 hese cortical immature neurons (cINs) retain developmentally undifferentiated states in adulthood, th

295 em were transcriptionally, functionally, and developmentally unique compared to Tem cells.

296 nd Myod1 are sequence-related but induce two developmentally unrelated lineages-that is, neuronal and

297 9.7%) of 91 835 non-Indigenous children were developmentally vulnerable on one domain or more.

298 indicated the reverse-polarity current seen developmentally was a manifestation of the same ion chan

299 al effects on select immune phenotypes arise developmentally, where the maternal and neonatal microbi

300 sense of obligation is intimately connected developmentally with the formation of a shared agent "we