ライフサイエンスコーパス: diacylglycerol lipase

1 , which is co-localized presynaptically with diacylglycerol lipase.

2 ntial activities of phosphoinositidase C and diacylglycerol lipase.

3 mediated by the enzymes phospholipase C and diacylglycerol lipase.

4 he sequential activities of phospholipase C, diacylglycerol lipase, 5-lipo-oxygenease, and leukotrien

5 Diacylglycerol lipase a (DAGLa), a major biosynthetic en

6 sustained rise in intracellular calcium, and diacylglycerol lipase activity.

7 sn-1-Diacylglycerol lipase alpha (DAGL-alpha) is the main enz

8 s the role of the main 2-AG producing enzyme diacylglycerol lipase alpha (DAGL-alpha).

9 Both diacylglycerol lipase alpha (DAGLalpha) and DAGLbeta can

10 e Sprague-Dawley rats were injected with the diacylglycerol lipase alpha (DAGLalpha) inhibitor LEI-10

11 The administration of the diacylglycerol lipase alpha (DAGLalpha) inhibitor LEI-10

12 Diacylglycerol lipase alpha (DAGLalpha) is responsible f

13 nced expression of a biosynthesizing enzyme (diacylglycerol lipase alpha (DAGLalpha)) of 2-AG in tast

14 e expression of the 2-AG-synthesizing enzyme diacylglycerol lipase alpha (DGLalpha) from ventral tegm

15 t mice in which the 2-AG-synthesizing enzyme diacylglycerol lipase alpha (DGLalpha) was deleted in dM

16 cy by deleting its primary synthetic enzyme, diacylglycerol lipase alpha (DGLalpha), from dopamine D1

17 rade signal 2-arachidonoylglycerol (2-AG) by diacylglycerol lipase alpha (DGLalpha).

18 ybridization, we measured CB1R, GAD(67), and diacylglycerol lipase alpha (the synthesizing enzyme for

19 lethanolamine phospholipase D [NAPE-PLD] and diacylglycerol lipase alpha [DAGLalpha]) in the spinal c

20 pocampal protein concentrations for the sn-1-diacylglycerol lipase alpha and beta isoforms, synthesiz

21 hosphoinositide-specific phospholipase C and diacylglycerol lipase alpha is known, alternative pathwa

22 Expression of diacylglycerol lipase alpha mRNA, which is not altered i

23 c glutamate receptor 5a (mGluR5a), Homer 2b, diacylglycerol lipase alpha, and CB(1)R.

24 d proteins involved in eCB signaling such as diacylglycerol lipase alpha, N-acyl-phosphatidylethanola

25 d by inhibiting the 2-AG-synthesizing enzyme diacylglycerol lipase alpha.

26 etic deletion or pharmacologic inhibition of diacylglycerol lipase-alpha (DAGL-alpha) impairs hippoca

27 Diacylglycerol lipase-alpha (DAGL-alpha), the principal

28 f endocannabinoid (eCB) biosynthetic enzymes diacylglycerol lipase-alpha (DAGLalpha) and -beta (DAGLb

29 1a))-positive GABAergic interneurons express diacylglycerol lipase-alpha (DGL-alpha), a synthesizing

30 nteraction between the 2-AG synthetic enzyme diacylglycerol lipase-alpha (DGLalpha) and calcium/calmo

31 2-arachidonoyl-sn-glycerol-producing enzyme, diacylglycerol lipase-alpha (endocannabinoid signalosome

32 Here we show the localization of diacylglycerol lipase-alpha and -beta (DGLalpha/beta), i

33 of 2-AG is calcium-dependent and mediated by diacylglycerol lipase and COX-2.

34 can be inferred in part through measures of diacylglycerol lipase and monoglyceride lipase, which sy

35 ne cells of the pars tuberalis and coexpress diacylglycerol lipase B - an endocannabinoid biosyntheti

36 loss-of-function mutations in 2-AG synthase diacylglycerol lipase beta (DAGLB) to an early onset aut

37 heimer's (Braak stage VI), with ectopic sn-1-diacylglycerol lipase beta expression found in microglia

38 Diacylglycerol lipase-beta (DAGLbeta) serves as a princi

39 embers of this large enzyme class, including diacylglycerol lipase-beta (DAGLbeta), a principal biosy

40 Here we identify DAGLB (diacylglycerol lipase-beta), a key enzyme for generation

41 s), type 1 cannabinoid receptors (CB1Rs) and diacylglycerol lipase (DAGL) in the VTA.

42 f inhibitors of the 2-AG-synthesizing enzyme diacylglycerol lipase (DAGL) or the 2-AG-degrading enzym

43 tidylethanolaminephospholipase D (NAPE-PLD), diacylglycerol lipase (DAGL), or phospholipase C (PLC),

44 Diacylglycerol lipase (DAGL)-alpha and -beta are enzymes

45 eaving group of triazole urea derivatives as diacylglycerol lipase (DAGL)-alpha inhibitors.

46 to selectively inhibit 2-AG biosynthesis by diacylglycerol lipase (DAGL).

47 the enzyme responsible for 2-AG generation, diacylglycerol lipase (DAGL).

48 ), an inhibitor of the 2-AG synthesis enzyme diacylglycerol lipase (DAGL).

49 Diacylglycerol lipases (DAGLalpha and DAGLbeta) convert

50 t as selective and CNS-active inhibitors for diacylglycerol lipases (DAGLs), enzymes responsible for

51 a mechanism dependent upon both postsynaptic diacylglycerol lipase (DGL) activity, which releases 2-A

52 aptic response was blocked by inhibitors for diacylglycerol lipase (DGL), which biosynthesizes 2-AG,

53 cerol, suggesting that SMc01003 also acts as diacylglycerol lipase (DglA) in its native background.

54 ease in 2-LG amounts depended on the PLC and diacylglycerol lipase encoded by norpA and inaE, respect

55 d 2-arachidonylglycerol 1) is synthesized by diacylglycerol lipase in pyramidal neurons; 2) travels r

56 xygenases), LOXs (lipooxygenases), and DGLs (diacylglycerol lipases), indicating the involvement of a

57 ited by antibodies to the FGF receptor and a diacylglycerol lipase inhibitor (RHC80267) that blocks t

58 mediated by 2-AG since it was blocked by the diacylglycerol lipase inhibitor DO34.

59 in iron-overloaded NRVMs was reduced by the diacylglycerol lipase inhibitor RHC80267 but was largely

60 e phospholipase C inhibitor U-73122, and the diacylglycerol lipase inhibitor tetrahydrolipstatin (THL

61 lglycerol synthesis that is inhibited by the diacylglycerol lipase inhibitor, DO34.

62 of either the CB1R antagonist, AM251, or the diacylglycerol lipase inhibitor, DO34.

63 bition of the major 2-AG synthesizing enzyme diacylglycerol lipase or blockade of CB1 receptors aboli

64 main containing 4 protein, cyclooxygenase 2, diacylglycerol lipase paralogs (DAGLalpha, DAGLbeta), fa

65 ction via the phosphatidate phosphohydrolase/diacylglycerol lipase pathway.

66 Our findings suggest Vaha functions as a diacylglycerol lipase physiologically, by being a molecu

67 Inhibitors of diacylglycerol lipase (RHC 80267), cyclooxygenase (indom

68 phatidate phosphohydrolase (propranolol) and diacylglycerol lipase (RHC-80267), attenuated ET-1-induc

69 An inhibitor of diacylglycerol lipase, RHC-80267, inhibited AVP-evoked S

70 : cytosolic phospholipase A(2) (cPLA(2)) and diacylglycerol lipase; the former cascade is responsible

71 the postsynaptic membrane-associated lipase, diacylglycerol lipase type-alpha (DGL-alpha), in mGlu re

72 B(1)R (SR141716 and AM251) and inhibition of diacylglycerol lipase using tetrahydrolipstatin also aug

73 concentrations of the 2-AG synthetic enzyme diacylglycerol lipase were not affected by PLX treatment

74 rs, we demonstrated that phospholipase D and diacylglycerol lipase were required for providing AA for