ライフサイエンスコーパス: diamide

1 , and the calcium-activated calcium channel (diamides).

2 A1 increased cellular sensitivity to tBH and diamide.

3 FP-tagged TNFRs exposed to the thiol oxidant diamide.

4 tance to catechol, MHQ, 1,4-benzoquinone and diamide.

5 as examined using the thiol-specific oxidant diamide.

6 crosslinking of transmembrane cysteines with diamide.

7 e, and g within adenosyl cobyrinic acid a,c-diamide.

8 ells treated with the thiol-specific oxidant diamide.

9 hydrogen peroxide, menadione, paraquat, and diamide.

10 ene hydroperoxide, t-butyl hydroperoxide, or diamide.

11 lted in the production of cobyrinic acid a,c-diamide.

12 tolerance but dispensable for resistance to diamide.

13 tein is treated with strong oxidants such as diamide.

14 e to both H2O2 and the thiol-oxidizing agent diamide.

15 shock and the thiol-specific oxidizing agent diamide.

16 the formation of ox-hHSF1 in the presence of diamide.

17 y induced (70-fold) following treatment with diamide.

18 anothione disulfide following oxidation with diamide.

19 owth inhibition by the thiol-oxidizing agent diamide.

20 e inactivation of NFI by the oxidizing agent diamide.

21 ility to induce this activity on exposure to diamide.

22 formation of the intersubunit cross-links by diamide.

23 identical to that obtained in the absence of diamide.

24 the channel by the disulfide inducing agent, diamide.

25 by amidation to form Ni-sirohydrochlorin a,c-diamide.

26 s increased sensitivity to the thiol oxidant diamide.

27 cued by the addition of the chemical oxidant diamide.

28 rmeant bis-quaternary ammonium derivative of diamide.

29 C56S mutation was resistant to the effect of diamide.

30 nstrate increased resistance to both tBH and diamide.

31 amide, and expression of trxD was induced by diamide.

32 -step synthesis of phthalimides and phthalic diamides.

33 e to new mode of action compounds, including diamides.

34 ate two important properties of these simple diamides.

35 In contrast, diamide 1) activates the channel, 2) enhances [3H]ryanod

36 tive double Heck cyclizations of cyclohexene diamides 1 and 3 form contiguous quaternary stereocenter

37 Treatment with high concentrations of diamide (1 mm) resulted in an increase in the FRET signa

38 reatment of cells with low concentrations of diamide (1 mum) that was not sufficient to provoke TNFR

39 for example, N,N,N'N'-tetrahexylpropane-1,3-diamide (1), N,N'-dibutyl-N,N'-dimethyl-2-tetradecylprop

40 nd eliminated the necessity of preparing the diamide 13.

41 ibutyl-N,N'-dimethyl-2-tetradecylpropane-1,3-diamide (2), or N,N,N'N'-tetramethylpropane-1,3-diamide

42 In situ imidazolate-4,5-diamide-2-olate linker generation leads to the formation

43 prepared zinc-deuteroporphyrin diamide (ZnMb(diamide), 3), which converts the charged groups to neutr

44 10 mm) and inhibited by the oxidizing agent diamide (30 mum).

45 abeled zinc porphyrin derivative (ZnMb((15)N-diamide), 4).

46 sporter mutants, Deltaatr1 and Deltaflr1, to diamide, 4-NQO, and cadmium.

47 sic internal aromatic amine of 3 to give the diamide 5.

48 mide (2), or N,N,N'N'-tetramethylpropane-1,3-diamide (6), are poorly organized for metal ion complexa

49 Diamide 7 was prepared, and the X-ray crystal structure

50 id 2a (MB05032) led to the identification of diamide 8 (MB06322), the first reported orally efficacio

51 tolerance to the oxidative stress caused by diamide (a drainer of metabolic NADPH) in the absence of

52 peroxide, whereas they are more sensitive to diamide, a disulfide bond-inducing agent.

53 These effects were reversed using diamide, a glutathionylation catalyst.

54 Control studies involving diamide, a membrane-stiffening agent, suggest that the R

55 of N-bis-(3-phenyl-propyl)9-oxo-fluorene-2,7-diamide, a novel PARG inhibitor, significantly reduces b

56 We showed that diamide, a reagent that promotes disulfide bond formatio

57 M containing 25 mM glucose were treated with diamide, a thiol oxidant, at a concentration that did no

58 ramide, whereas treatment of astrocytes with diamide, a thiol-depleting agent, alone caused degradati

59 Treatment with diamide, a thiol-oxidizing agent, induced formation of d

60 These diamides act on the ryanodine receptor (RyR), a large en

61 and cell lysates containing Sav mutants with diamide affords up to >100 TON's and only a modest erosi

62 cells treated with diethyl maleate (DEM) or diamide, agents that deplete cellular thiols, had increa

63 ibited by pro-oxidants hydrogen peroxide and diamide, although these two pro-oxidants by themselves h

64 Neutral N3S diamide amine thiol chelators with no adjacent positive

65 perimental and DFT study of the reactions of diamide-amine supported titanium hydrazides with alkynes

66 e inducible by exposure of cells to H2O2 and diamide, among other oxidative stress eliciting compound

67 vity to dithiothreitol, a reductant, whereas diamide, an oxidant had no effect on the growth of the m

68 data are consistent with a model in which 1) diamide, an oxidizing agent, simultaneously produces an

69 hylmaleimide (NEM), an alkylating agent, and diamide, an oxidizing agent, were examined for effects o

70 UVEC) monolayers for 6 hours with 0.2 mmol/L diamide and 1 mmol/L buthionine sulfoximine (BSO) decrea

71 age at the alpha-carbon position through the diamide and alpha-amidation pathways.

72 Diamide and amido-ester derivatives proved to be efficie

73 Thiol reactive agents such as diamide and cadmium induce zinc efflux by interfering wi

74 Diamide and dithiothreitol were reagents used respective

75 tion 199 was resistant to inhibition by both diamide and glutathionylation, thus implicating this as

76 Although both diamide and H(2)O(2) have been used to impose oxidative

77 e stress elicited by the redox-active agents diamide and H(2)O(2).

78 ional residues upon exposure to pro-oxidants diamide and H2O2 Here we hypothesize that routine storag

79 d function by the action of oxidants such as diamide and hydrogen peroxide; however, prior DNA bindin

80 or the glutathione-specific oxidizing agent diamide and in whole newborn mouse eyes incubated in the

81 In contrast, the oxidizing agents diamide and menadione inhibited the development of hillo

82 Diamide and N-ethylmaleimide likewise inhibit the disloc

83 potential and/or free thiol status, such as diamide and N-ethylmaleimide.

84 erential sensitivity of their RNA binding to diamide and N-ethylmaleimide.

85 mutant was more sensitive to the effects of diamide and oxygen than the parent strain.

86 fluorescence and comparison to the oxidants diamide and phenylhydrazine revealed that oxidation does

87 vely) to serine rendered HSF1 insensitive to diamide and prevented its conversion to ox-HSF1.

88 Treatment of PTP1B with diamide and reduced glutathione or with only glutathione

89 In the presence of a low concentration of diamide and reduced glutathione, the kinase was rapidly

90 rsine oxide (PheArs) is greater than that by diamide and t-butylhydroperoxide (TBH), yet the increase

91 was also induced by the GSH-oxidizing agent diamide and the GSH-conjugating agent N-ethylmaleimide,

92 ed sensitivity to the thiol-specific oxidant diamide and to the redox cycling compounds menadione and

93 es of extractants (organophosphorus ligands, diamides and N-heterocycles), with a focus on the separa

94 elial cells with the thiol-specific oxidant, diamide, and assessed activities of the UPP.

95 The response of the roGFP2 toward H2O2, diamide, and dithiothreitol was titrated and used to det

96 tective during exposure to the thiol oxidant diamide, and expression of trxD was induced by diamide.

97 esulted in increased sensitivity to benomyl, diamide, and menadione, but not 4-NQO, cycloheximide, or

98 tment of mouse brain synaptosomes with H2O2, diamide, and sodium nitroprusside caused aggregation of

99 also produced 1-desmethylcobyrinic acid a,c-diamide, and strains that had neither cbiP nor cbiA synt

100 the present study, we examined the effect of diamide, and the model oxidant hydrogen peroxide (H(2)O(

101 partially inhibited by N-ethylmaleimide and diamide, and unaffected by arsenite.

102 Diamide appears to oxidize particular cysteine residues

103 In addition, single channels activated by diamide are further activated by the addition of NEM.

104 ortho- and para-benzoquinones which act like diamide as thiol-reactive electrophiles.

105 in vivo is reduced when cells are exposed to diamide, as shown by the enhanced stability of an SsrA-t

106 ious concentrations of glutathione (GSH) and diamide at 25 degrees C for 1 hour.

107 Diamide at concentrations of up to 5 mM reduced the axia

108 iolation, we used the thiol-specific oxidant diamide because its oxidant activity is restricted to in

109 the double mutant R91C/G98D was resistant to diamide block.

110 ar proteins also shows that sulforaphane and diamide, both known to react with cysteine amino acids,

111 ese mutant factors confer hyperresistance to diamide but hypersensitivity to H(2)O(2).

112 bsence of ATP or adenosyl cobyrinic acid a,c-diamide, but the rate of glutamine hydrolysis is enhance

113 Moreover, the oxidant diamide can restore growth and secretion in ero1 mutants

114 to thiol-specific stress conditions, such as diamide, catechol and 2-methylhydroquinone (MHQ).

115 Diamide caused a rapid increase in oxidized glutathione

116 cordings and inside-out patches, H(2)O(2) or diamide caused a strong inhibition of the vascular K(ATP

117 Oxidation of GSH with the thiol oxidant diamide caused significant decreases in cellular GSH and

118 kinase inhibitor to increase deformability), diamide (cell-stiffening agent), cilostazol (phosphodies

119 ning approach and identified a benzimidazole diamide compound designated GSK669 that selectively inhi

120 Of critical importance, a cyclic tartronic diamide coordinates the MetAP-2 metal ion in the active

121 Oxidizing agents, in particular diamide, could further enhance transcription of the trxB

122 When incubated with oxygen or diamide, CprK undergoes inactivation; subsequent treatme

123 d ATP release (111.7 +/- 17.2%) in older and diamide decreased RBC deformability (RCTT: 8.955 +/- 0.1

124 The corresponding diamide derivative was also synthesized and analyzed fro

125 These results imply that the diester or diamide derivatives of the d-tetrapeptides self-assemble

126 Phosphonic diamides derived from amino acid esters were discovered

127 ation of a novel benzylpiperazine adamantane diamide-derived compound that inhibits EboV infection.

128 by thiol-ene addition copolymerization with diamide diene monomers.

129 Notably, H(2)O(2) and diamide differentially affected the RyR2-FKBP12.6 intera

130 A diamide diimine ligand, [{-CH=N(1,2-C6H4)NH(2,6-iPr2C6H3

131 Moreover, in both HAECs and BAECs, diamide dramatically increased both the rate and magnitu

132 When examined for promoters up-regulated by diamide, effective Pap1 binding to these targets require

133 All diamide effects can be reversed by the reducing agent, d

134 Diamide either cross-links phase 1 sulfhydryls or causes

135 l modification by N-ethylmaleimide (NEM) and diamide, even under conditions that led to severe cellul

136 tionally, miRNAs are involved in response to diamide exposure, indicating they are probably associate

137 atment with the sulfhydryl oxidizing reagent diamide formed the faster migrating, slower dissociating

138 dly washed it away, and resumed culturing in diamide-free medium (post-diamide stress culturing).

139 TP-dependent synthesis of cobyrinic acid a,c-diamide from cobyrinic acid using either glutamine or am

140 nsformations to afford a wide variety of 1,2-diamide functionalized products.

141 phosphotyrosine residue, and a diester or a diamide group, we find that, regardless of the stereoche

142 Loss of TH catalytic activity caused by diamide-GSH is partially recovered by DTT and glutaredox

143 The effect of diamide-GSH on TH activity is prevented by dithiothreito

144 were inhibited strongly by a combination of diamide/GSH or H(2)O(2)/GSH but not by either alone.

145 e in binding strength between the urea and a diamide guest in 0.1 M NBu4B(C6F5)4/CH2Cl2.

146 Similar to diamide, H(2)O(2) increased the sensitivity of HAECs to

147 Diamide had no effect on the C150S mutant enzyme, sugges

148 s and treated with three oxidative reagents (diamide, hydrogen peroxide, and phenylhydrazine) to cros

149 ns but can be oxidized by the strong oxidant diamide, implying that the redox potential for the thiol

150 mine, is inhibited by the sulfhydryl oxidant diamide in a concentration-dependent manner.

151 loss of sensitivity to both sulforaphane and diamide in electrophoretic mobility shift assay analysis

152 Treatment of TH with diamide in the presence of [(35)S]GSH results in the inc

153 ance to two different oxidants, H(2)O(2) and diamide, in cells that contain an intact glutamate catab

154 Likewise, GSH markedly potentiated diamide inactivation of a PKC isozyme mixture purified f

155 Diamide inactivation of cPKC-alpha and its potentiation

156 the heme diester or, for the first time, the diamide increases the second-order rate constant of the

157 train produced 1-desmethylcobyrinic acid a,c-diamide, indicating that CbiD is involved in C-1 methyla

158 I, only 1-nitrosocyclohexalycetate (NCA) and diamide induced reproducible protein phosphorylation.

159 cetyl cysteine attenuated GSSG elevation and diamide-induced apoptosis.

160 Diamide-induced blocking was reversed by disulfide bond-

161 GSH potentiation of diamide-induced cPKC-alpha inactivation was associated w

162 We describe a Pap1-Oxs1 pathway for diamide-induced disulfide stress in Schizosaccharomyces

163 Diamide-induced expression of trxC, trxE, and trxF incre

164 Diamide-induced formation of the Cys-150 disulfide bond

165 Diamide induces intersubunit dimer formation of both the

166 reincubation of the latent HSF1 monomer with diamide inhibited the in vitro heat-induced activation a

167 thermore, oxidizing agents, such as H2O2 and diamide, inhibited Gag processing of wild-type virions,

168 vidence that the G4946E RyR mutation impairs diamide insecticide binding.

169 dine receptor (RyR) was highly correlated to diamide insecticide resistance in field populations of P

170 cation enzymes have been associated with the diamide insecticide resistance in the diamondback moth,

171 Recently acquired resistance to diamide insecticides in this species is thought to be du

172 Diamide insecticides target insect ryanodine receptors (

173 gs elucidate the mode of action of different diamide insecticides, reveal the molecular mechanism of

174 The recent introduction of synthetic diamide insecticides, with a novel mode of action, poten

175 Calcium pulstrodes based on the diamide ionophore AU-1 were characterized and applied to

176 Diamide is a chemical oxidant that selectively converts

177 to treatment with the thiol-specific oxidant diamide is the result of transcription initiation at the

178 r conditions in which cAPK is inactivated by diamide, it is also readily thiolated.

179 III alkyl complexes supported by a ferrocene diamide ligand (1,1'-fc(NSi(t)BuMe(2))(2)) have been fou

180 -sandwich complexes supported by a ferrocene diamide ligand (NN(fc)) are reported.

181 Utilizing a rigid ferrocene diamide ligand (NN(TBS)), a Dy(III) SIM, (NN(TBS))DyI(TH

182 a) benzyl complexes supported by a ferrocene diamide ligand are reactive toward aromatic N-heterocycl

183 yridyl complex supported by a 1,1'-ferrocene diamide ligand is reported.

184 nzyl complexes supported by a ferrocene 1,1'-diamide ligand.

185 benzyl complex supported by a ferrocene 1,1'-diamide ligand.

186 t, thus demonstrating the potential of rigid diamide ligands in the design of new SIMs with defined m

187 Inhibition of TNF-alpha- and diamide-mediated depletion of GSH, elevation of ceramide

188 of Deltayap1 cells to the oxidants H(2)O(2), diamide, menadione and tert-butyl hydroperoxide.

189 rial libraries of dimeric iminodiacetic acid diamides, novel small molecule binders of EPOr were iden

190 Mitochondrial dysfunction in response to diamide occurred in stages, progressing from oscillation

191 um(0) and the chiral ligand derived from the diamide of trans-1,2-diaminocyclohexane and 2-diphenylph

192 sm, we report the semisynthesis of mono- and diamides of biliverdin IXalpha and those of its non-natu

193 were rapidly linked through oxidation (with diamide) of the Cys 73 disulfide bond, and the relative

194 itroxyl donors and the thiol-oxidizing agent diamide on cardiac myocyte protein phosphorylation and o

195 The inhibitory effect of diamide on TH catalytic activity is enhanced significant

196 ap1 form a complex when cells are exposed to diamide or Cd that causes disulfide stress.

197 cellular Ca(2+), acute treatment with either diamide or H(2)O(2) increased the number of BAECs exhibi

198 xB gene was induced following treatment with diamide or H(2)O(2) or exposure to oxygen.

199 he same high level in the presence of either diamide or H(2)O(2), these mutant factors confer hyperre

200 tivation was induced by treating CaMKII with diamide or histamine chloramine, two thiol-oxidizing age

201 the treatment of footprinting reactions with diamide or hydrogen peroxide.

202 f cellular proteins by incubating cells with diamide or incubating cellular extracts with GSSG oxidiz

203 In cells treated with the oxidizing agents diamide or phenylarsine oxide, S6K1 phosphorylation incr

204 utyl hydroperoxide, cumene hydroperoxide, or diamide) or by addition of Zn2+.

205 creased after exposure of M. tuberculosis to diamide; out of these, 39 were not induced in the sigH m

206 Using diamide oxidation and chemical cross-linking of the prot

207 inhibited after incubation with the oxidants diamide, oxidized glutathione, or hydrogen peroxide or w

208 64 microM), and the crystal structure of the diamide-oxidized protein was determined to be nearly ide

209 genes, although transcription is induced by diamide, Oxs1 or Pap1 plays a negative role with full de

210 opentadienylmono(oxazolinyl)borato zirconium diamide {Ph2B(C5H4)(Ox(4S-iPr,Me2))}Zr(NMe2)2.

211 Low concentrations of diamide plus 1,3-bis(2 chloroethyl)-1-nitrosourea (BCNU)

212 esence exaggerated the suppressive effect of diamide plus BCNU.

213 Diamide plus BSO-induced thiol/disulfide imbalance was a

214 Here we show that a simple tertiary diamide precipitates gold selectively from aqueous acidi

215 Diamide pretreatment increased the sensitivity of HAECs

216 Optimization of the diamide prodrugs of phosphonic acid 2a (MB05032) led to

217 ells, an exposure to the oxidant H(2)O(2) or diamide produced concentration-dependent inhibitions of

218 The time course for the synthesis of the diamide product and positional isotope exchange experime

219 and the synthesis of the cobyrinic acid a,c-diamide product are uncoupled.

220 gma(H) induction, we exposed both strains to diamide, rapidly washed it away, and resumed culturing i

221 servation that the disruption of spectrin by diamide reduces force generation in the cell.

222 residues does not similarly affect H2O2 and diamide regulation of yAP-1 function.

223 These desirable properties of phosphonic diamides represent significant improvements over existin

224 -CRD), that is required for H(2)O(2) but not diamide resistance and influences the localization of th

225 er the up-regulation of PxRyR is involved in diamide resistance remains unknown.

226 nce but does not contribute significantly to diamide resistance.

227 olerance from promoters of genes involved in diamide resistance.

228 ver from oxidant insults of 20 and 40 microM diamide, respectively.

229 the sulfydryl-oxidizing agents, H(2)O(2) and diamide, result in diminished RyR2-FKBP12.6 binding.

230 Treatment of cells with diamide resulted in a dose-dependent increase in the GSS

231 atment of the affinity-purified enzymes with diamide resulted in the formation of disulfide bonds and

232 Treatment of intact PC12 cells with diamide results in a concentration-dependent inhibition

233 P-2 inhibitors introduced a cyclic tartronic diamide scaffold.

234 with aryl chlorides and bromides, two oxalic diamides serve as the powerful ligands.

235 Mouse fibroblast cells treated with diamide showed a reversible decrease in cAPK activity.

236 with either adriamycin or the thiol oxidant diamide showed elevated levels of glutathione disulfide

237 ne dicarboxylic acid bis[N,N-dimethylamide] (diamide), significantly reduced this interaction.

238 ral reorganisation of the initially chelated diamide spectator ligand, computational quantum chemical

239 Here we show that two pyridine diamide-strapped calix[4]pyrroles induce coupled chlorid

240 sumed culturing in diamide-free medium (post-diamide stress culturing).

241 a(H) (Delta-sigma(H)) is more susceptible to diamide stress than wild-type M. tuberculosis.

242 ranscriptional reprogramming-the response to diamide stress.

243 ng to the sigH regulon, especially following diamide stress.

244 Fluorescent alpha,alpha'-diamide substituted bi- and terthiophene derivatives wer

245 mol for unsubstituted DBCOD to 68 kJ/mol for diamide-substituted DBCOD.

246 tramolecular hydrogen bonding formed by 1,10-diamide substitution stabilizes Boat, spiking the temper

247 Diamides, such as flubendiamide and chlorantraniliprole,

248 ferent ox-HSF1 conformers in the presence of diamide, suggesting that C3 could be disulfide cross-lin

249 The sulfhydryl-reactive oxidative agent diamide suppressed LTC(4)S activity and induced a revers

250 4,6-dioxopirimidines are designed as key 1,3-diamide surrogates that perform exceedingly in amine-squ

251 Cobyrinic acid a,c-diamide synthetase from Salmonella typhimurium (CbiA) is

252 Monoesters, monoamides, and diamides tested generally exhibited low in vitro activit

253 H(2)O(2) and more sensitive to menadione and diamide than wild-type cells.

254 lity (22-47%) was achieved using phosphonate diamides that convert to the corresponding phosphonic ac

255 [gamma-18O4]-ATP and adenosyl cobyrinic a,c-diamide the enzyme will catalyze the positional isotope

256 ug menadione, the sulfhydryl-oxidizing agent diamide, the disulfide-reducing agent dithiothreitol, hy

257 ing pretreatment of mitochondria with TBH or diamide, the Ki for ADP increased to 50-100 microM, wher

258 on is enhanced by exposure to either H2O2 or diamide, the protein responds to the oxidative stress pr

259 ocrystal featuring biaxial coordination of a diamide to the unhindered iodolium compound.

260 The addition of increasing concentrations of diamide to these cells resulted in oxidation of the acti

261 otonate the NH center in the five-coordinate diamides to give the amido-amine, e.g., [Cp*Ir(TsDPEN)](

262 d upon the addition of a recognized oxidant (diamide) to the RBC sample followed by a subsequent retu

263 n the use of pharmacological agents, such as diamide, to alter the UCP3 glutathionylation state.

264 uric acids, a subtype of pseudosymmetric 1,3-diamides, to yield the corresponding 5,5-disubstituted (

265 eractive in terms of their ability to confer diamide tolerance to cells but fail to provide even norm

266 rom 0.02 in untreated cells to > or = 0.5 in diamide-treated cells were accompanied by dose-dependent

267 ross-linked oxidized hHSF1 (ox-hHSF1) in the diamide-treated sample.

268 Diamide treatment caused partial release of Zn from ClpX

269 ntly induced at least 50-fold in response to diamide treatment in a sigR-dependent manner.

270 srA tag recognized by ClpXP was inhibited by diamide treatment in vitro.

271 Thus, we demonstrated that reperfusion and diamide treatment increased S-thiolation of a number of

272 medium during the recovery period following diamide treatment increased the extent of restoration of

273 This effect was also induced by diamide treatment of Ku and could be abrogated by dithio

274 Diamide treatment of NIH3T3 cells likewise induced poten

275 Thus, diamide treatment of nuclear extracts strongly reduces t

276 5)S]cysteine, to label cellular GSH prior to diamide treatment, followed by immunoprecipitation of TH

277 minates the methionine auxotrophy imposed by diamide treatment, suggesting that modulation of MetE ac

278 ve stress as induced by H2O2, menadione, and diamide treatment.

279 cA/ClpCP-catalyzed proteolysis in vitro, but diamide used at the concentrations that inhibited ClpXP

280 h various substrates, including diesters and diamides, via (1)H NMR spectroscopy and isothermal titra

281 ied after FKBP binding had occurred, whereas diamide was always effective.

282 The effect of diamide was blocked by pretreatment with N-ethylmaleimid

283 n binding receptor based on dipicolinic acid diamide was equipped with thiol groups in the amidic sid

284 The 1,4-diamide was more potent across the tumor panel than the

285 The effect of diamide was reversed by the addition of excess DTT, sugg

286 The sensitivity to diamide was suppressed by deletion of the TRX2 gene.

287 We report that the efficacy of both diamides was dramatically reduced in clonal Sf9 cells st

288 Diamide weakly inactivated purified recombinant cPKC-alp

289 d when molar ratios of gammaC-crystallin-GSH-diamide were 1:2:5 and 1:10:25, respectively.

290 These effects of diamide were dose-dependent and were rapidly and quantit

291 led to a greater extent only by paraquat and diamide, whereas they are less susceptible to the effect

292 We found that diamide, which affects spectrin, reduces the axial stiff

293 sensitivity to oxidative stress agents like diamide, which are known to alter the oxidation reductio

294 Oxidation by diamide, which converts thiols to the disulfide, inactiv

295 of kinase activity to the sulfhydryl oxidant diamide, which inhibited by promoting an intramolecular

296 They are only slightly hypersensitive to diamide, which is nitrogen source-dependent, and minimal

297 cid halides furnished the corresponding N,N'-diamides, which were converted into N,N'-dithioamides by

298 the resulting CCl3 ketone to form a range of diamides with high diastereo- and enantioselectivity (up

299 including tert-butyl hydroperoxide (tBH) and diamide without affecting cell proliferation, baseline a

300 ith the newly prepared zinc-deuteroporphyrin diamide (ZnMb(diamide), 3), which converts the charged g