ライフサイエンスコーパス: diamino

1 2,2'-Diamino-1,1'-bianthryl (15) has been resolved into enant

2 The chiral scaffold for the catalyst is 2,2'-diamino-1,1'-binaphthalene (BINAM), and a bis-conjugate

3 regio- and atroposelective synthesis of 2,2'-diamino-1,1'-binaphthalenes (BINAMs).

4 Condensation of fac-Re(5,6-diamino-1,10-phenanthroline)(CO)3Cl to o-quinone edge de

5 cis- and trans-2,6-diamino-1,2,3,5,6,7-hexahydro-s-indacene-2,6-dicarboxyli

6 novel carbon-supported copper complex of 3,5-diamino-1,2,4-triazole (Cu-tri/C) is investigated as a c

7 the formation of the cocrystal of 5 with 3,5-diamino-1,2,4-triazole, which was found to be remarkably

8 thesis of 1,4-disubstituted 3-amino- and 3,5-diamino-1,2,4-triazoles based on quaternization of readi

9 optimize the pharmacological profile of [1,2-diamino-1,2-bis(4-fluorophenyl)ethane]dichloridoplatinum

10 A method for the synthesis of chiral 1,2-diamino-1,2-dideoxy-myo-inositol-based bis-pyridyl ligan

11 2,4-Diamino-1,3,5-triazinyl (DAT) groups are known to form N

12 , we have synthesized compounds in which 2,4-diamino-1,3,5-triazinyl groups are attached to derivativ

13 For 2,3-diamino-1,4-benzoquinone, adiabatic E(T1) and E(S1) ener

14 = azophenine = N,N',N",N'''-tetraphenyl-2,5-diamino-1,4-diiminobenzoquinone) affords the complex [(T

15 eed via the initial formation of dimeric 2,5-diamino-1,4-dioxane species, which were hydrolyzed in si

16 We report a new naphthalene bis(4,8-diamino-1,5-dicarboxyl)amide (NBA) building block for po

17 idines 6 and 17 were prepared by heating 2,7-diamino-1,8-naphthyridine (13) with butylisocyanate and

18 oplatinum(II) complexes, we synthesized [1,2-diamino-1-(4-fluorophenyl)alkanol]dichloridoplatinum(II)

19 [threo-1,2-Diamino-1-(4-fluorophenyl)propan]dichloridoplatinum(II)

20 fluoroacetic acid generates the unstable 2,3-diamino-1-(phenylsulfonyl)indole (3), which can be trapp

21 2-Hydroxy-4,6-diamino-[1,3,5]triazines are described which are a novel

22 ernization of 1-substituted 3-amino- and 3,5-diamino-1H-1,2,4-triazoles by many alkyl halides proceed

23 e global nucleophilicity of 3-amino- and 3,5-diamino-1H-1,2,4-triazoles was predicted to be higher th

24 New derivatives of 1,1-diamino-2, 2-dinitroethene (FOX-7) are reported.

25 nhibited by appropriate MAPK inhibitors 1, 4-diamino-2, 3-dicyano-1, 4-bis (2-aminophenylthio) butadi

26 '-methoxyphenyl)-oxanaphthalen-4-one and 1,4-diamino-2, 3-dicyano-1,4-bis(2-aminophenylthio)butadiene

27 reatment of cells with the MKK inhibitor 1,4-diamino-2, 3-dicyano-1,4-bis[2-aminophenylthio]butadiene

28 [omega-[4-(4-cyanophenyl)phenoxy]hexyl] 4,4'-diamino-2,2'-biphenyldicarboxylate (nCBBP, n = 6), abbre

29 characterization of two new halogenated 1,1-diamino-2,2-dinitroethene (FOX-7) compounds and three ha

30 ion were controllably synthesized by using 1-diamino-2,2-dinitroethene as a precursor.

31 try demonstrated that pro-treatment with 1,4-diamino-2,3-dicyano-1,4-bis butadiene (U0126) could sign

32 as inhibited by the ERK kinase inhibitor 1,4-diamino-2,3-dicyano-1,4-bis(2-aminophenylthio) butadiene

33 2'-amino-3'-methoxyflavone (PD98059) or 1,4-diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)-butadiene

34 romoter activity was repressed by U0126 [1,4-diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene]

35 hoxy-3,4-difluoro-benzamide], and U0126 [1,4-diamino-2,3-dicyano-1,4-bis(2-aminophynylthio)butadiene]

36 llular signal-regulated kinase inhibitor 1,4-diamino-2,3-dicyano-1,4-bis(2-aminophynyltio)butadiene (

37 th pertussis toxin, MAPK activation with 1,4-diamino-2,3-dicyano-1,4-bis(2-aminophynyltio)butadiene (

38 lated kinase (ERK)-dependent [blocked by 1,4-diamino-2,3-dicyano-1,4-bis(methylthio) butadiene (U0126

39 ted protein kinase kinase/ERK inhibitor [1,4-diamino-2,3-dicyano-1,4-bis(methylthio)butadiene (U0126)

40 This down-regulation was attenuated by 1,4-diamino-2,3-dicyano-1,4-bis(methylthio)butadiene (U0126)

41 Two other MEK inhibitors, 1,4-diamino-2,3-dicyano-1,4-bis(methylthio)butadiene (U0126)

42 On the other hand, inhibition by 1,4-diamino-2,3-dicyano-1,4-bis(methylthio)butadiene (U0126)

43 2'-amino-3'-methoxyflavone (PD98059) or 1,4-diamino-2,3-dicyano-1,4-bis(methylthio)butadiene (U0126)

44 e MAP kinase kinase 1/2 inhibitor U0126 [1,4-diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto) butad

45 tivated protein kinase-kinase) inhibitor 1,4-diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto) butad

46 ls with the MAPK kinase (MEK) inhibitors 1,4-diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto) butad

47 tenuated by the MEK/ERK inhibitor U0126 [1,4-diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto)butadi

48 bolished by the MEK/ERK inhibitor U0126 [1,4-diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto)butadi

49 tivated protein) kinase inhibitor U0126 (1,4-diamino-2,3-dicyano-1,4-bis[2-amino-phenylthio]butadiene

50 f the MAP kinase kinase inhibitor U0126 (1,4-diamino-2,3-dicyano-1,4-bis[2-amino-phenylthio]butadiene

51 ed kinase (ERK) 1/2 activation by UO126 (1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio] butadiene

52 PD98059 or another MEK inhibitor, 1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene

53 egulated kinase kinase inhibitor, U0126 (1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene)

54 AP kinase kinase (MEK) inhibitor, U0126 (1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene)

55 synthesize lipid A molecules containing 2,3-diamino-2,3-dideoxy-d-glucopyranose (GlcN3N) units in pl

56 d GnnB, involved in the formation of the 2,3-diamino-2,3-dideoxy-d-glucopyranose moiety.

57 sence a beta-1',6-linked disaccharide of 2,3-diamino-2,3-dideoxy-d-glucopyranose units.

58 ine residues are replaced with the sugar 2,3-diamino-2,3-dideoxy-d-glucopyranose.

59 nterobacterial lipid A was replaced by a 2,3-diamino-2,3-dideoxy-d-glucopyranosyl-(GlcpN3N) disacchar

60 ing abundance of LA d-glucosamine versus 2,3-diamino-2,3-dideoxy-d-glucose, and phosphorylation statu

61 of the products have been converted into 2,3-diamino-2,3-dideoxyglycosides and methyl N-acetyl-D-livi

62 A 1,4-diamino-2,3-disila-1,3-butadiene derivative of compositi

63 (1), 1,4-diamino-2-chloro-2-butene (2), 1,6-diamino-2,4-hexadiyne (3), and 2-chloro-5-phthalimidopen

64 tment of T. vaginalis T016 with >/=20 mM 1,4-diamino-2-butanone (DAB) to inhibit ODC resulted in grow

65 bacterial transformant was inhibited by 1, 4-diamino-2-butanone (DAB), a known inhibitor of eukaryoti

66 Reactions of 1,4-diamino-2-butyne with selected amine oxidases were also

67 n the formation of diversely substituted 1,4-diamino-2-butynes,is described.

68 nd aryl group at the 1,4-position of the 1,4-diamino-2-butynes.

69 , 4-(2-naphthyloxy)-2-butyn-1-amine (1), 1,4-diamino-2-chloro-2-butene (2), 1,6-diamino-2,4-hexadiyne

70 unit could self-assemble dendrimers, the 2,8-diamino-2-N-ethylpyrimido-(4,5-b)(1,8)naphthyridine-3H-4

71 days by visualizing RPE ingrowth with 4',6'-diamino-2-phenylindole (DAPI) filters.

72 t counting of propidium iodide (PI) or 4',6'-diamino-2-phenylindole (DAPI)-stained cells.

73 Our results from 4, 6-diamino-2-phenylindole (DAPI)-stained spreads showed tha

74 eloped based on multiphoton imaging of 4',6'-diamino-2-phenylindole (DAPI)-stained tissue to quantify

75 Cell nuclei were stained with 4',6'-diamino-2-phenylindole (DAPI).

76 ng with a membrane impermeable dye and 4',6'-diamino-2-phenylindole (DAPI).

77 alized to the acidocalcisomes by using 4',6'-diamino-2-phenylindole staining and identified by using

78 o localized to the volutin granules by 4',6'-diamino-2-phenylindole staining.

79 labeled with markers for nuclei (DAPI; 4',6'-diamino-2-phenylindole), endothelial cells (isolectin IB

80 nsduced cells as demonstrated by DAPI (4', 6-diamino-2-phenylindole), TUNEL (terminal deoxynucleotidy

81 Diamino-2-quinoxalinols are reacted with salicylaldehyde

82 2,4-Diamino-[2'-methoxy-5'-(3-carboxyphenyl)ethynylbenzyl]py

83 tantially weaker against Pc and Tg DHFR, 2,4-diamino-[2'-methoxy-5'-(4-carboxyphenyl)ethynylbenzyl]py

84 e (4), was obtained by the nitration of 5,5'-diamino-3,3'-azo-1,2,4-oxadiazole using 100 % nitric aci

85 N(6)-(2-Deoxy-D-erythro-pentofuranosyl)-2,6-diamino-3,4-dihydro-4-oxo-5-N-methylf ormamidopyrimidine

86 s and related higher sugars derived from 5,7-diamino-3,5,7,9-tetradeoxynon-2-ulosonic acids.

87 The pseudaminic acids are a family of 5,7-diamino-3,5,7,9-tetradeoxynonulosonic acids that are fun

88 synthetic route to three derivatives of 3,5-diamino-3,5-dideoxy-d-ribofuranose.

89 exclusively regioselective synthesis of 2,7-diamino-3,6-dibromo- and 2,3-diamino-6,7-dibromo-NDIs fo

90 posure to a solution of monodeprotonated 2,5-diamino-3,6-dibromo-1,4-benzoquinone or 2,5-diamino-3,6-

91 e and chloroform without an additive the 2,7-diamino-3,6-dibromo-NDI isomer was formed regioselective

92 -diamino-3,6-dibromo-1,4-benzoquinone or 2,5-diamino-3,6-dichloro-1,4-benzoquinone, proceeding throug

93 N'-bis-(6-chloro-2-methoxy-acridin-9-yl)-1,8-diamino-3,6-dioxaoctane, and (1-[[4-(6-chloro-2-methoxy-

94 The third possible regioisomer 2,6-diamino-3,7-dibromo product was formed, if at all, in an

95 propan]dichloridoplatinum(II) and [threo-2,3-diamino-3-(4-fluorophenyl)propan-1-ol]dichloridoplatinum

96 egio- and stereoselective synthesis of a 1,2-diamino-3-hydroxycyclohexane.

97 2-(2-Diamino-3-methoxyphenyl-4H-1-benzopyran-4-one (PD98059)

98 on with the MAP kinase kinase inhibitor 2-(2-diamino-3-methoxyphenyl-4H-1-benzopyran-4-one (PD98059)

99 on of the appropriate 1-nitroalkene with 2,6-diamino-3H-pyrimidin-4-one or 2,4,6-triaminopyrimidine,

100 Condensation of 1,2-diamino-4,5-bis(n-alkoxy)arenes with an oligopyridyl-typ

101 ompared with both published HPAE-PAD and 1,2-diamino-4,5-methylenedioxybenzene (DMB) derivatization f

102 hy (RP-UHPLC) analysis of acid-released, 1,2-diamino-4,5-methylenedioxybenzene (DMB) labeled sialic a

103 ses, including Western blotting and mild 1,2-diamino-4,5-methylenedioxybenzene-HPLC, that revealed th

104 Condensation of 5,6-diamino-4,7-phenanthroline with glyoxal provides 1,4,5,1

105 O uptake in the presence of a hexamine, 1,21-diamino-4,9,13, 18-tetraazahenicosane (H2N(CH2)(3)NH(CH2

106 in a high-throughput screening campaign, 3,6-diamino-4-(2-halophenyl)-2-benzoylthieno[2,3-b]pyridine-

107 A major DNA oxidation product, 2,2-diamino-4-[(2-deoxy-beta-D-erythro-pentofuranosyl)amino]

108 ing and CDK inhibition was reproduced by 2,6-diamino-4-cyclohexylmethyloxy-5-nitrosopyrimidine (NU602

109 eoxy-alpha,beta-d-erythropentofuranosyl)-2,6-diamino-4-hydroxy -5-formamidopyrimidine) is a modified

110 oxy-alpha,beta-d-erythro-pentofuranosyl)-2,6-diamino-4-hydroxy-5-f ormamidopyrimidine (Fapy.dGTP) and

111 Another common lesion, 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapydG), shares

112 hydantoin (Sp), guanidinohydantoin (Gh), 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG) and 4,6-

113 The oxidatively induced DNA lesions 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG) and 4,6-

114 genic 8-oxo-7,8-dihydroguanine (8-oxoG), 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG), 4,6-dia

115 to 8-oxo-7,8-dihydroguanine (8-oxoG) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG).

116 SB in the repair of formamidopyrimidines 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua) and 4,

117 NA lesions 5-hydroxycytosine (5-OH-Cyt), 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua) and 4,

118 mino-5-formamidopyrimidine (FapyAde) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua) from D

119 Excision of purine lesions 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua), 4,6-d

120 nly other one acted on by S3 protein was 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua).

121 fied in DNA, only purine-derived lesions 2,6-diamino-4-hydroxy-5-formamidopyrimidine and 4,6-diamino-

122 NEIL1 possess common substrates, namely, 2,6-diamino-4-hydroxy-5-formamidopyrimidine and 4,6-diamino-

123 and additional artifactual increases in 2,6-diamino-4-hydroxy-5-formamidopyrimidine, 4,6-diamino-5-f

124 c DNA lesions (7,8-dihydro-8-oxoguanine; 2,6-diamino-4-hydroxy-5-formamidopyrimidine; 4,6-diamino-5-f

125 oxy-alpha,beta-D-erythro-pentafuranosyl)-2,6-diamino-4-hydroxy-5-formyl amidopyrimidine (Fapy-dG), is

126 The Ntg1 and Ntg2 proteins also release 2, 6-diamino-4-hydroxy-5-N-methylformamido-pyrimidine from da

127 Cyclocondensation of 2,4-diamino-4-oxopyrimidine with the alpha-bromoketones, cou

128 Silica gel was modified with 2,6-diamino-4-phenil-1,3,5-triazine and characterized by FTI

129 ine radicals at G1 to form alkali-labile 2,5-diamino-4H-imidazolone lesions (Iz1Py).

130 ydroxy-5-formamidopyrimidine (FapyG) and 4,6-diamino- 5-formamidopyrimidine (FapyA), but not 8-oxo-7,

131 The synthesis of seven 2,4-diamino-5,6,7,8-tetrahydro-7-substituted pyrido[4',3':4,

132 ypyrimidine to afford regiospecifically 2, 4-diamino-5,6,7,8-tetrahydropyrido[4',3':4,5]furo[2, 3-d]p

133 omplex of NADPH, the potent antifolate [2, 4-diamino-5- inverted question mark3-[3-(2-acetyloxyethyl)

134 ritrexim (PTX), 10 previously unreported 2,4-diamino-5-(2'-methoxy-5'-substituted)benzylpyrimidines (

135 ombine the enzyme-binding selectivity of 2,4-diamino-5-(3',4',5'-trimethoxybenzyl)pyrimidine (trimeth

136 The new analogues were all obtained from 2,4-diamino-5-(5'-iodo-2'-methoxybenzyl)pyrimidine via a Son

137 the Ma enzyme and was the most selective 2,4-diamino-5-(5'-substituted benzyl)pyrimidine inhibitor of

138 horamidites 23 and 25 were prepared from 2,4-diamino-5-(beta-d-ribofuranosyl)-1,3-pyrimidine (22) and

139 enol, followed by a Wittig reaction with 2,4-diamino-5-(chloromethyl)furo[2,3-d]pyrimidine (6), catal

140 were synthesized by a Wittig reaction of 2,4-diamino-5-(chloromethyl)furo[2,3-d]pyrimidine with ethyl

141 the substrate and NADPH as the cofactor, 2,4-diamino-5-[(2-methoxy-4-carboxybutyloxy)benzyl]pyrimidin

142 exim, PTX), seven previously undescribed 2,4-diamino-5-[2'-methoxy-5'-(substituted benzyl)]pyrimidine

143 xy-5-alkoxybenzyl]pyrimidines (3a-e) and 2,4-diamino-5-[2-methoxy-5-(omega-carboxyalkyloxy)benzyl]pyr

144 A series of previously undescribed 2,4-diamino-5-[2-methoxy-5-alkoxybenzyl]pyrimidines (3a-e) a

145 The final compound, 2,4-diamino-5-[3'-(4-carboxy-1-butynyl)-4'-bromo-5'-methoxyb

146 dole dihydrochloride), propidium iodide (3,8-diamino-5-[3-(diethylmethylammonio)propyl]-6-phenylphena

147 2,4-Diamino-5-[5'-(4-carboxy-1-butynyl)-2'-methoxybenzyl]pyr

148 2,4-Diamino-5-[5'-(5-carboxy-1-pentynyl)-2'-methoxybenzyl]py

149 2,4-Diamino-5-[5'-(5-carboxypentyl)-2'-methoxybenzyl]pyrimid

150 2,4-Diamino-5-[5'-(6-carboxy-1-hexynyl)-2'-methoxybenzyl]pyr

151 or the synthesis of 3, 4, and 11-27 were 2,4-diamino-5-alkylsubstituted-7H-pyrrolo[2,3-d]pyrimidines,

152 cation for the classical analogue N-[4-[(2,4-diamino-5-deaza-6,7,8,9-tetrahydropyrido[3,4-g]pteridin-

153 Seven novel 2,4-diamino-5-deaza-6,7,8,9-tetrahydropyrido[3,4-g]pteridine

154 esis to construct the tricyclic nucleus, 2,4-diamino-5-deaza-7H-6,7,8,9-tetrahydropyrido[3,4-g]pterid

155 ypotheses were developed for a series of 2,4-diamino-5-deazapteridine inhibitors of Mycobacterium avi

156 The cation of the salt ethidium bromide (3,8-diamino-5-ethyl-6-phenylphenanthridinium bromide) has be

157 4,6-Diamino-5-formamidopyrimidine (Fapy*dG) is an abundant f

158 ydroxy-5-formamidopyrimidine (FapyG) and 4,6-diamino-5-formamidopyrimidine (FapyA) are formed abundan

159 4-hydroxy-5-formamidopyrimidine (FapyG), 4,6-diamino-5-formamidopyrimidine (FapyA), and 8-oxo-7,8-dih

160 bits a strong preference for excision of 4,6-diamino-5-formamidopyrimidine (FapyAde) and 2,6-diamino-

161 oxy-5-formamidopyrimidine (FapyGua) and 4, 6-diamino-5-formamidopyrimidine (FapyAde) in cultured cell

162 hydroxy-5-formamidopyrimidine (FapyGua), 4,6-diamino-5-formamidopyrimidine (FapyAde), and 8-hydroxygu

163 roxy-5-formamidopyrimidine (FapyGua) and 4,6-diamino-5-formamidopyrimidine (FapyAde), which are subst

164 studies show elevated 8-OHG, 8-OHA, and 5,6-diamino-5-formamidopyrimidine in both nuclear and mtDNA

165 mino-4-hydroxy-5-formamidopyrimidine and 4,6-diamino-5-formamidopyrimidine were significantly excised

166 diamino-4-hydroxy-5-formamidopyrimidine; 4,6-diamino-5-formamidopyrimidine) and strong plant growth i

167 These were 4, 6-diamino-5-formamidopyrimidine, 5,6-dihydroxyuracil, and

168 diamino-4-hydroxy-5-formamidopyrimidine, 4,6-diamino-5-formamidopyrimidine, and 8-hydroxyadenine.

169 rmined for the following modified bases: 4,6-diamino-5-formamidopyrimidine, cis- and trans-thymine gl

170 derivatives and a purine-derived lesion, 4,6-diamino-5-formamidopyrimidine, from DNA containing multi

171 mino-4-hydroxy-5-formamidopyrimidine and 4,6-diamino-5-formamidopyrimidine.

172 The 2,4-diamino-5-ketopyrimidines 6 reported here represent a no

173 nanoparticles as thiolate ligands, using 3,8-diamino-5-mercaptododecyl-6-phenylphenanthridinium (ethi

174 hree DHFRs compared to the corresponding 2,4-diamino-5-methyl analogues previously reported; however,

175 Two novel classical antifolates N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-

176 (trimethoprim, TMP) with the potency of 2,4-diamino-5-methyl-6-(2',5'-dimethoxybenzyl)pyrido[2,3-d]p

177 2,4-diamino-5-methyl-6-(substituted-phenyl)thiopyrrolo[2,3-d

178 Thirteen 2,4-diamino-5-methyl-6-[(monosubstituted anilino)methyl]pyri

179 loro groups from the phenyl ring in the 2, 4-diamino-5-methyl-6-[(substituted anilino)methyl]pyrido[2

180 mbination of potency and selectivity was 2,4-diamino-5-methyl-6-[2'-(5-carboxy-1-butynyl)-5'-methoxy]

181 tive amination of a common intermediate, 2,4-diamino-5-methylpyrido[2, 3-d]pyrimidine-6-carbonitrile

182 Z)-6-(2-[2,5-dimethoxyphenyl]ethen-1-yl)-2,4-diamino-5-methylpyrido[2,3-d ]pyrimidine (SRI-9662) were

183 t inhibitors 6-([5-quinolylamino]methyl)-2,4-diamino-5-methylpyrido[2,3-d]pyrimidine (SRI-9439) and (

184 Compounds 3 and 4 were obtained from 2,4-diamino-5-methylpyrrolo[2,3-d]pyrimidine 7 and 2-amino-4

185 Synthesis was achieved from 2,4-diamino-5-methypyrrolo[2,3-d]pyrimidine and substituted

186 AGF152 (6) and AGF163 (8), 2,4-diamino-5-substituted-furo[2,3-d]pyrimidine thiophene re

187 Racemic 2,2'-diamino-6,6'-dimethylbiphenyl is resolved using simulate

188 MF under similar reaction conditions the 2,3-diamino-6,7-dibromo isomer was observed as the major reg

189 ynthesis of 2,7-diamino-3,6-dibromo- and 2,3-diamino-6,7-dibromo-NDIs for the first time.

190 SAR exploration of the 2,4-diamino-6,7-dimethoxyquinazoline template led to the dis

191 Initial SAR exploration of the 2,4-diamino-6,7-dimethoxyquinazoline template represented by

192 lfonyl]pyrido[3, 2-d]pyrimidine (7), and 2,4-diamino-6-(2', 5'-dimethoxyanilino)pyrido[3,2-d]pyrimidi

193 hoprim (TMP), the heretofore undescribed 2,4-diamino-6-(2',5'-disubstituted benzyl)pyrido[2,3-d]pyrim

194 A series of 2,4-diamino-6-(arylaminomethyl)pyrido[2,3-d]pyrimidines were

195 Nineteen previously undescribed 2,4-diamino-6-(arylmethyl)-5,6,7, 8-tetrahydroquinazolines (

196 from p-(N-methyl)aminobenzoic acid with 2,4-diamino-6-(bromomethyl)pteridine gave the target compoun

197 ylamine analogues were synthesized from 2, 4-diamino-6-(bromomethyl)pteridine in 50-75% yield by reac

198 ctive (the less active enantiomer, S-(-)-2,4-diamino-6-(fluromethyl)-5-(2,3,5-trichlorophenyl)-pyrimi

199 member of the lamotrigine family, R-(-)-2,4-diamino-6-(fluromethyl)-5-(2,3,5-trichlorophenyl)-pyrimi

200 phenyl)thio]pyrido[3,2-d]pyrimidine (4), 2,4-diamino-6-[(2'-methoxyphenyl)sulfonyl]pyrido[3, 2-d]pyri

201 trimetrexate (TMQ) or PTX, most notably 2, 4-diamino-6-[(3',4'- dimethoxyphenyl)thio]pyrido[3,2-d]pyr

202 Three simple 2, 4-diamino-6-alkyl-5,6,7,8-tetrahydroquinazoline model comp

203 tituted anilines with pivaloyl protected 2,4-diamino-6-bromo-pyrido[2,3-d]pyrimidine was successfully

204 Toward this end, 2,4-diamino-6-hydroxypyrimidine (DAHP) has been used as the

205 Condensation of 2,4-diamino-6-hydroxypyrimidine 6 with 5a-d afforded the 6-s

206 bromomethylketones and condensation with 2,4-diamino-6-hydroxypyrimidine afforded the 6-substituted p

207 Compound 2 was obtained from 2,4-diamino-6-hydroxypyrimidine and 1, 3-dichloroacetone.

208 O synthase because GPTCH-1 blockade with 2,4-diamino-6-hydroxypyrimidine during shear inhibited dimer

209 ndensation of 3-bromo-4-piperidone with 2, 4-diamino-6-hydroxypyrimidine to afford regiospecifically

210 mine, and an inhibitor of BH4 synthesis (2,4-diamino-6-hydroxypyrimidine) uncoupled eNOS, increasing

211 r of BH(4), because the GTPCH inhibitor, 2,4-diamino-6-hydroxypyrimidine, blocked cytokine-stimulated

212 ited by the GTP-cyclohydrolase inhibitor 2,4-diamino-6-hydroxypyrimidine.

213 Reduction of commercially available 2,4-diamino-6-nitroquinazoline 14 with Raney nickel afforded

214 yrimidinone 5'-phosphate (compound 3) to 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate (

215 e was shown to catalyze the formation of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (

216 ogues, SCO 1441 and 2687, convert GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (

217 produce the canonical product of GCH II, 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (

218 nucleotide-dependent reduction of either 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (

219 ounds synthesized, (2S,8RS,11RS)-5-thia-2,11-diamino-8-methyldodecanedioic acid (11) was the most pot

220 Enantiomerically enriched syn-alpha,beta-diamino acid derivatives can be obtained in excellent yi

221 ategy provided highly substituted alpha,beta-diamino acid derivatives with excellent levels of stereo

222 luoromethyl esters, precursors of alpha,beta-diamino acid derivatives.

223 terminal NlpC/P60 domain (gamma-d-glutamyl-l-diamino acid endopeptidase) and is expected to play an i

224 od-coccus cycle, and contained lysine as the diamino acid in its cell wall.

225 with commercially available fluorophores and diamino acid starting materials.

226 on the photochemical synthesis of amino and diamino acid structures in simulated interstellar and ci

227 cursor to L-lysine is D,L-diaminopimelate, a diamino acid which is incorporated into the pentapeptide

228 Sugar diamino acids (SDAs), which differ from the widely used

229 otected delta,epsilon-unsaturated alpha,beta-diamino acids as templates for the preparation of 12 new

230 differentially protected erythro-alpha,beta-diamino acids from N-tosyloxy beta-lactams is reported.

231 ock approach for the synthesis of alpha,beta-diamino acids is described, which involves the diastereo

232 tes for the preparation of 12 new alpha,beta-diamino acids of biological relevance using simple techn

233 synthesis of N(beta)-substituted alpha,beta-diamino acids, such as 1-isohistidine, tau-histidinoalan

234 ptides prepared using commercially available diamino acids, which are Alloc-protected on the side-cha

235 all eight possible stereoisomers of a chiral diamino alcohol core are generated from two amino acids.

236 Elaboration of these beta,gamma-diamino and alpha-hydroxy-beta,gamma-diamino esters gave

237 ly obtained at room temperature using amino, diamino, and triamino silica at recoveries of 93% (11 h)

238 ategy for the synthesis of chiral alpha,beta-diamino- and alpha-amino,beta-hydroxy ester derivatives

239 oped to date, which are, however, limited to diamino- and dialkyl-substituted species.

240 le carbamate synthon 6 with various terminal diamino- and dihydroxyalkanes.

241 beronetriketone with a series of substituted diamino- and tetramino-arenes.

242 pounds with fluoro-, cyano-, nitro-, amino-, diamino-, and nitroamino substituents are expected to em

243 reaction between substituted orthoesters and diamino benzene dithiol.

244 ups, we have investigated the effects of the diamino biguanide compound metformin and of hyperglycemi

245 xidant and gives rise to anti-configured 2,3-diamino carboxylates as bicyclic sulfamate derivatives.

246 A series of amino alcohol- and diamino-cis-decalins were synthesized and their conforma

247 he first example, to our knowledge, of a 2,4-diamino classical antifolate that has potent inhibitory

248 tant kinases (Arg to Ala mutations) by small diamino compounds, particularly imidazole; however, the

249 the MCMs with pH-insensitive pyrazine-based diamino cross-linkers, pH-responsive, photonic multicomp

250 kinetically by the subsequent addition of a diamino crosslinking agent, which underwent covalent cro

251 The cis diamino derivative showed a stronger hyperporphyrin effe

252 ng H-Trp-Arg-Nva-Arg-Tyr-NH(2) using various diamino-dicarboxylic acids containing either di-, tri-,

253 mplex with a side-on mu-eta(2),eta(2)-peroxo diamino dicopper(II) structure, accounting for 80-90% of

254 The solution structures of the dilithiated diamino diethers are also characterized by a variety of

255 Three dilithiated diamino diethers including (2S,2'S)-1,1'-(butane-1,4-diy

256 Four different chiral diamino diethers synthesized from N-isopropyl valinol or

257 Crystal structures of the dilithiated diamino diethers were determined by X-ray diffraction.

258 the diazotization reaction of dapsone (4,4'-diamino-diphenyl sulphone, DAP) and (naphthyl)ethylenedi

259 latter effect rests on stabilization of the diamino enol tautomer by Dipp substitution, and could be

260 denes readily form isolable, though reactive diamino enols with aldehydes and enals.

261 eto tautomers of imidazolidinylidene-derived diamino enols, and computational thermodynamic data for

262 a,gamma-diamino and alpha-hydroxy-beta,gamma-diamino esters gave the protected forms of the 3-deoxy-3

263 was saponified and coupled with alpha,gamma-diamino esters to afford the corresponding dipeptide der

264 o the corresponding alpha-hydroxy-beta,gamma-diamino esters.

265 ugmenting the accessible range of beta,gamma-diamino esters.

266 o- and diastereoisomerically pure beta,gamma-diamino esters.

267 The reaction of diaryl ketoalkynes with 1,2-diamino ethane leads to the full scission of the triple

268 urface structure has been documented for 1,2-diamino ethane radical cation and features two parallel

269 Nine classic diamino furo[2,3-d]pyrimidine antifolates with unsubstit

270 ationic polymer poly(cystamine bisacrylamide-diamino hexane) (p(CBA-DAH)) was modified with poly(ethy

271 o crude mixtures of porphyrazines containing diamino-hexapropyl-porphyrazine magnesium complexes.

272 DAHP (2,4-diamino hydroxyl pyrimidine), a specific inhibitor of GC

273 regioselectively, while without TBAF the 2,3-diamino isomer was formed exclusively.

274 , as in dichloromethane without TBAF the 2,7-diamino isomer was formed regioselectively, while withou

275 Oxidation of diamino MDI derivatives yields di- and tetraimide functi

276 he corresponding difunctionalized alpha,beta-diamino methyl esters 15-18, 20.

277 rrolo[2, 3-d]pyrimidine ring binds in a "2,4-diamino mode" in which the pyrrole nitrogen mimics the 4

278 Legionaminic acid is a nine-carbon diamino monosaccharide that is found coating the surface

279 es 7-hydroxy methotrexate (7-OH MTX) and 2,4-diamino-N(10)-methylpteroic acid (DAMPA) in pure solutio

280 ound that the conventional beta-alanine-3,3'-diamino-N-methyldipropylamine (betaDa) linker strongly l

281 The combination of a bent diamino(nickel(II) porphyrin) with 2-formylpyridine and

282 > sigma*(C-C) "negative hyperconjugation" in diamino-o-carborane (1) causes rapid inversion in the am

283 taining the divalent metal chelator ethylene diamino-o-dihydroxyphenyl acetic acid, and the addition

284 interaction for various derivatives of 1 and diamino-o-dodecahedron (2) provides a rational approach

285 ages were synthesized from substituted 4,4''-diamino-p-terphenyls, 2-formylpyridine, and iron(II).

286 ound, like other Leishmania spp., to take up diamino-PC (PC2) for red light inactivation.

287 lamine, n-propylamine, n-butylamine, and 1,5-diamino pentane as mimics for the side chain of lysine (

288 PS transformations of 1,6- and/or 1,7-diamino perylenes result in 2-fold annulated nitrogen-co

289 tic protocol for the formation of alpha,beta-diamino phenyl alanine derivatives.

290 robenzene sulfonic acid), the DNA stain 4',6-diamino-phenylindole, and confocal laser scanning micros

291 Epoxy groups were used to bind a layer of diamino-poly(ethylene glycol) (DAPEG) with terminal amin

292 The resulting diamino products belong to imidazolidine analogue and ca

293 The anti-angiogenic agent, diamino propane tetraiodothyroacetic acid (DAT), is a th

294 pyrazine-bis(carboxamides) derived from 3,5-diamino-pyrazine-2,5-dicarboxylic acid bearing neutral a

295 ketone (8) followed by condensation with 2,6-diamino-pyrimidin-4-one (7) to afford the substituted fu

296 thyl-2',7'-difluorofluorescein diacetate and diamino-rhodamine-4M, respectively.

297 nes to give the corresponding monoamino- and diamino-substituted porphyrins in high yields under mild

298 lore the regioselectivity as three different diamino-substituted regioisomeric products can be formed

299 st members of a new family of spiro-bis-(1,9-diamino-substituted-phenalenyl)boron neutral radicals.

300 timization of orally active antimalarial 2,4-diamino-thienopyrimidines and with the help of metabolit