ライフサイエンスコーパス: diazepam

1 not including any classical BZ agonists like diazepam).

2 rdings, 0.051 after 2.5 mg and 5 mg doses of diazepam).

3 tor (GABA(A)R) positive allosteric modulator diazepam.

4 decreased in severity by the anticonvulsant diazepam.

5 ockout mice show greater motor sedation with diazepam.

6 amitriptyline, carbamazepine, rofecoxib, and diazepam.

7 hese neurons in the motor-sedative effect of diazepam.

8 enhancement of I(tonic) by EtOH, but not by diazepam.

9 cal midazolam was more effective than rectal diazepam.

10 by enhancing GABA-mediated inhibition using diazepam.

11 relative to the prototypical benzodiazepine, diazepam.

12 ely sensitive to GABAA and were modulated by diazepam.

13 e, and loreclezole; they were insensitive to diazepam.

14 his was not seen following similar dosing of diazepam.

15 re shared in part by the benzodiazepine drug diazepam.

16 the classical benzodiazepines alprazolam and diazepam.

17 sensitivity to etomidate, pentobarbitone or diazepam.

18 f EEG power in both bands was not changed by diazepam.

19 and presence of GABA and in the presence of diazepam.

20 detected anxiolytic effects of nicotine and diazepam.

21 azepam is likely to be a better therapy than diazepam.

22 anesthetics and for benzodiazepines such as diazepam.

23 of the GABA receptor- allosteric modulator, diazepam.

24 a following blockade of fear conditioning by diazepam.

25 iring effects of clinically used BZs such as diazepam.

26 channel conductance was relieved by 1 microM diazepam.

27 example in comparison with the commonly used diazepam.

28 hese effects to those achieved with systemic diazepam.

29 and contrasted to that obtained with 2mg/kg diazepam.

30 in improved efficacy or safety compared with diazepam.

31 espectively, were achieved for extraction of diazepam.

32 necessary for the reward-enhancing action of diazepam.

33 ors in the zero maze that were alleviated by diazepam.

34 Diazepam (0.1 mg/kg) and the 5-HT(1A) receptor agonist 8

35 In a test arena lit by high light, diazepam (0.1 mg/kg) increased social interaction, witho

36 Diazepam (0.1 mg/kg) significantly increased locomotor a

37 ffects of two drugs with anxiolytic actions, diazepam (0.1, 0.3 and 1 mg/kg) and nicotine (0.1 and 0.

38 Diazepam (0.3 and 1 mg/kg) produced a dose-related incre

39 , and received daily injection of vehicle or diazepam (1 mg/kg).

40 ngly the anxiolytic effects of mPFC infusion diazepam (1.5 mug/side) were also blocked by 5-HT deplet

41 erity, proliferation remained increased when diazepam (10 mg/kg) was used to reduce withdrawal severi

42 ockout mice and wild-type mice after saline, diazepam (1mg/kg), and alprazolam (0.3mg/kg) injections.

43 effect of a subsedative, anxiolytic dose of diazepam (2 mg kg intraperitoneal) was investigated in a

44 am (32 vs. 86 mg; p = .001), total amount of diazepam (248 vs. 562 mg; p = .001), and phenobarbital u

45 cephalographic (EEG) monitoring, after which diazepam (30 mg/kg) was administered.

46 t of alpha4beta3deltaH68A receptors by 1 muM diazepam, 30 mM EtOH, and 1 muM beta-carboline-3-carboxy

47 were increases in maximum individual dose of diazepam (32 vs. 86 mg; p = .001), total amount of diaze

48 nts treated with lorazepam (59.1 percent) or diazepam (42.6 percent) than patients given placebo (21.

49 HW by 18.4 +/- 6.2 % in 10:15 cells tested), diazepam (45.2 +/- 0.5 %, 6:7), etomidate (43.9 +/- 36 %

50 zed convulsive seizures received intravenous diazepam (5 mg), lorazepam (2 mg), or placebo.

51 r group) were injected (i.p.) with saline or diazepam (5 mg/kg or 10 mg/kg).

52 vements were noted with symptomatic therapy (diazepam, 6 of 6 patients treated, and oral baclofen, 3

53 influence of baclofen (a GABABR agonist) and diazepam (a classical benzodiazepine) versus placebo on

54 Shisa7 also potently enhances the action of diazepam, a classic benzodiazepine, on GABA(A)Rs.

55 Diazepam, a compound with a benzodiazepine nucleus but l

56 lse inhibition (PPI) that was ameliorated by diazepam, a GABA enhancer.

57 ors by bicuculline, a GABA antagonist, or by diazepam, a GABAergic agonist, did not significantly aff

58 e present experiment examined the effects of diazepam, a positive modulator at the GABA(A) receptor,

59 viously unresolved component (micromolar) of diazepam action, indicating that diazepam can modulate t

60 ed anxiety-like behavior in adulthood, while diazepam administered during P29-35 but not earlier nor

61 ects induced by an acute systemic RS67333 or diazepam administration were partially blocked after opt

62 sine (CCPA); the GABA(A) receptor modulators diazepam, allopregnanolone, and Ro15-4513; and the L-typ

63 Diazepam, allopregnanolone, Ro15-4513, and nitrendipine

64 There were 273 patients; 140 randomized to diazepam and 133 to lorazepam.

65 p required assisted ventilation (16.0% given diazepam and 17.6% given lorazepam; absolute risk differ

66 d similar to GABA but different than that of diazepam and bicuculline.

67 Rectal diazepam and buccal midazolam are used for emergency tre

68 found that activity is affected by tricaine, diazepam and flumazenil.

69 eine mutants were similar in the presence of diazepam and GABA.

70 observed with amitriptyline, carbamazepine, diazepam and gabapentin.

71 with ketamine or anesthetized with ketamine/diazepam and given drug or vehicle for various lengths o

72 d from epileptic DGCs were less sensitive to diazepam and had altered sensitivity to benzodiazepine i

73 e widely used benzodiazepine pharmaceuticals diazepam and human metabolites nordiazepam, temazepam an

74 y the sensitivity of GABA-evoked currents to diazepam and insensitivity to Zn(2+), together with the

75 at a 10- to 100-fold lower dose compared to diazepam and is characterized by favorable DMPK properti

76 ce receptors and differential sensitivity to diazepam and loss of function.

77 The results suggest that diazepam and midazolam each may have advantages for IVS.

78 ncreases in social interaction observed with diazepam and nicotine are similar to those seen in the w

79 IP) has been synthesized and used to extract diazepam and other benzodiazepines from hair samples via

80 he poisoning signs (and their alleviation by diazepam and phenobarbital) in mice are similar to those

81 y loss during sedation, while reducing total diazepam and post-operative analgesic dosages by 44% and

82 d vital signs while significantly decreasing diazepam and post-operative analgesic usage.

83 nes differently transcribed upon exposure to diazepam and propranolol, respectively.

84 ion, as well as non-dopaminergic treatments (diazepam and scopolamine) to examine non-specific effect

85 nd can be induced by conventional hypnotics, diazepam and sodium pentobarbital.

86 tify an additional membrane binding site for diazepam and suggest an allosteric mechanism for anaesth

87 icuculline and picrotoxin and facilitated by diazepam and zolpidem in a concentration-dependent manne

88 lity to seizures; (2) reduced sensitivity to diazepam and zolpidem, and increased sensitivity to Zn2+

89 ve effects, of two distinct BZ-site ligands, diazepam and zolpidem, which is relatively alpha1-subuni

90 rosemide, and loreclezole and insensitive to diazepam and zolpidem.

91 synaptic transmission in a manner similar to diazepam and zolpidem.

92 urgery involving preoperative oral sedation (diazepam) and local anesthetic, and the second using loc

93 a benzodiazepine anticonvulsant agent (e.g. diazepam) and/or physical cooling with an aim to relieve

94 enrolled, 66 received lorazepam, 68 received diazepam, and 71 received placebo.

95 hanol, n-propanol, t-butanol, pentobarbital, diazepam, and allopregnanolone.

96 gs: carbamazepine, atenolol, sulfamethazine, diazepam, and alprazolam.

97 elines emphasizing escalating bolus doses of diazepam, and barbiturates if necessary, significantly r

98 sher value, pretreatment with the anxiolytic diazepam, and biological sex.

99 i-effective mixture exposure to propranolol, diazepam, and carbamazepine on the crustacean Daphnia ma

100 mine hydrochloride, lidocaine hydrochloride, diazepam, and fluoxetine hydrochloride that meet U.S. Ph

101 d current enhancement by the benzodiazepine, diazepam, and that the gamma2 subunit K289M mutation dec

102 receptors were potentiated by pentobarbital, diazepam, and the neurosteroid (3alpha,5alpha)-3-hydroxy

103 y insensitive to enhancement by zolpidem and diazepam, and were enhanced by loreclezole and inhibited

104 ICs elicited during withdrawal from ethanol, diazepam, and zolpidem, and measured consumption of and

105 Functionally diazepam appeared to counteract the endogenous down-regu

106 In procedures lasting over 45 minutes, diazepam appears to be more clinically advantageous incl

107 stimated free concentrations of SH-I-048A or diazepam are able to elicit, suggested a similarity betw

108 al circuits mediating the sedative action of diazepam are unknown.

109 Benzodiazepines such as diazepam are widely prescribed as anxiolytics and sleep

110 of which the benzodiazepines (BZDs), such as diazepam, are the best described.

111 However, rats treated with diazepam at 15 min post-injury had significantly shorter

112 As anticipated, diazepam attenuated CUS-induced behavioral despair and c

113 ubunits in mice with a 129X1/SvJ background, diazepam becomes a subtype-specific modulator of the rem

114 Rats administered systemic diazepam before fear conditioning displayed both anxioly

115 contain a conserved acyl-CoA-binding protein/diazepam binding inhibitor (ACBP/DBI) motif.

116 Diazepam binding inhibitor (DBI) protein is a BZ site li

117 Also, in early-weaned animals, diazepam binding inhibitor and actin-related protein 2/3

118 enzodiazepine receptors, we find that both a diazepam binding inhibitor peptide and diazepam (Valium)

119 he mammalian homolog of AcbA is processed to diazepam binding inhibitor that binds to the GABA(A) rec

120 fatty acid metabolism and extracellularly as diazepam binding inhibitor, the precursor of endozepine

121 Diazepam-binding inhibitor (DBI) and its processing prod

122 Emerging evidence indicates that diazepam-binding inhibitor (DBI) mediates an endogenous

123 Concomitantly, its endogenous ligand, diazepam-binding inhibitor (DBI), is upregulated in the

124 amyl hydrolase (GGH), emmprin, survivin, and diazepam-binding inhibitor (DBI).

125 as determined to be identical to that of the diazepam-binding inhibitor (DBI).

126 The cytochrome P450 Cyp6a2 and the diazepam-binding inhibitor gene (Dbi) were over transcri

127 ontaining 7 (Acbd7) is a paralog gene of the diazepam-binding inhibitor/Acyl-CoA binding protein in w

128 Diazepam blocked the fear-conditioning-induced increase

129 states, three nonconducting states, resting, diazepam-bound and potentiating propofol-bound, and two

130 results provide structural evidence that the diazepam-bound state represents an intermediate conforma

131 (-/H) mice to the motor-depressing action of diazepam, but each of these conditional mutants had a si

132 orazepam may be more effective or safer than diazepam, but lorazepam is not Food and Drug Administrat

133 romolar) of diazepam action, indicating that diazepam can modulate the GABAA-receptor channel through

134 In wild-type and alpha1-point-mutated mice, diazepam caused a dose-dependent reduction in ICSS thres

135 scaffold to develop a photocaged version of diazepam (CD) that was tested on basolateral amygdala (B

136 e been studied, such as ketamine, midazolam, diazepam, clonazepam, propofol, pentobarbital, chloral h

137 Three experiments were conducted each with a diazepam control (0.25, 0.5 and 0.75 mg/kg).

138 Rats treated with diazepam did not differ in mortality from injured rats t

139 Diazepam did not significantly decrease (18)F-FDG uptake

140 g METH exposure blocked the depletions while diazepam did not.

141 oth gamma(2)R43Q and beta(2)R117K also speed diazepam dissociation from the receptor's benzodiazepine

142 Because diazepam does not open the channel, these results provid

143 ntravenous sedation (IVS) using midazolam or diazepam during periodontal procedures on patient recall

144 that administration of the antianxiety drug diazepam during the peripubertal period prevents the hyp

145 Fetal exposure to diazepam (DZ), a positive modulator of GABA(A) receptors

146 Also, the use of diazepam (DZP) and congeners includes unwanted side effe

147 the positive allosteric GABA(A)-R modulators diazepam (DZP) and zolpidem.

148 istamine diphenhydramine (DPH), anti-anxiety diazepam (DZP), anti-seizure carbamazepine (CZP) drugs a

149 Here, we added diazepam early after oxygen-glucose deprivation and prev

150 ABA currents were consistently stimulated by diazepam (EC(50)=63 nM), zolpidem (EC(50)=85 nM), lorecl

151 Protracted administration of diazepam elicits tolerance, whereas discontinuation of t

152 d that the benzodiazepines flunitrazepam and diazepam enhanced extrasynaptic inhibition mediated by d

153 y, we show the positive allosteric modulator diazepam enhanced GABA-A currents on dopaminergic axons

154 Diazepam enhanced GABA-evoked currents less potently in

155 alleled by faster decay of mIPSCs, decreased diazepam enhancement of both mIPSCs and I(tonic), and pa

156 The benzodiazepine diazepam enhances the size of GABA(A) IPSPs; its effects

157 All benzodiazepine doses > or =3 mg/day in diazepam equivalents significantly increased the adjuste

158 Unlike phenobarbital or diazepam, flupirtine prevented animals from experiencing

159 cal midazolam was more effective than rectal diazepam for children presenting to hospital with acute

160 aken to compare buccal midazolam with rectal diazepam for emergency-room treatment of children aged 6

161 ciency for at least 30 direct extractions of diazepam from whole blood [relative standard deviation (

162 finity chromatography with flunitrazepam and diazepam (GABA(A) receptor) and MK-801 and NMDA (NMDA re

163 Specifically, diazepam given during P10-16 but not during later weeks

164 This study indicates that diazepam given orally in adult dosages does not cause si

165 in the lorazepam group as compared with the diazepam group and 2.3 (95 percent confidence interval,

166 inutes occurred in 101 of 140 (72.1%) in the diazepam group and 97 of 133 (72.9%) in the lorazepam gr

167 cent confidence interval, 1.0 to 5.9) in the diazepam group as compared with the placebo group.

168 or the lorazepam group, 10.3 percent for the diazepam group, and 22.5 percent for the placebo group (

169 these biodistribution data: The control and diazepam groups exhibited intense (18)F-FDG uptake in BA

170 Rats pre-treated with the 5 mg/kg dose of diazepam had significantly lower mortality (0%) than inj

171 10mg/kg dose of the novel ligand and 2mg/kg diazepam; however, SH-I-048A was relatively more active

172 by demonstrating increased level of anxiety; diazepam improved performance in the test.

173 lysis and based on the free concentration of diazepam in blood matrix was about 4.8% (desorption effi

174 Transient pharmacological enhancement by diazepam in BTBR mice during an early sensitive period r

175 c transmission and diminishes the effects of diazepam in mice.

176 The LOD and LOQ of diazepam in spiked hair samples were 0.09 and 0.14 ng/mg

177 idazolam and rectal administration of liquid diazepam in the acute treatment of seizures.

178 s reveal differential regulation of EGR-1 by diazepam in the central and lateral nuclei of the amygda

179 emerging as suitable alternatives to rectal diazepam in the initial treatment of status epilepticus.

180 used antiepileptic drugs, phenobarbital and diazepam, in preventing and suppressing seizures in both

181 s appear to be particularly important, since diazepam increased ICSS thresholds (reflecting an aversi

182 In the flurothyl model, phenobarbital and diazepam increased latency to seizure onset, but flupirt

183 However, diazepam increased mortality and bacterial load from S.

184 Alprazolam and diazepam increased the amplitude of the negative potenti

185 receptors (alpha2-GABAARs) are required for diazepam-induced anxiolysis, with no evidence for an inv

186 The diazepam-induced conformational change in the M3 segment

187 cysteine-accessibility method to investigate diazepam-induced conformational changes in the region of

188 of the beta(2) subunit had no effect on the diazepam-induced current and therefore these extrasynapt

189 Sensitivity to isoflurane- or diazepam-induced loss of righting reflex was decreased a

190 in-specific alpha1(-/-) mice showed enhanced diazepam-induced motor depression and increased expressi

191 nterface, as assayed by the rate of decay of diazepam-induced potentiation of GABA-evoked currents.

192 er identify the neuronal circuits supporting diazepam-induced sedation, we generated Emx1-cre-recombi

193 coherence at ca 20 Hz was reduced following diazepam injection, but the magnitude of this effect was

194 ted in both groups two-hours after SE with a diazepam injection.

195 r affected [(3)H]muscimol (3 nM) binding nor diazepam-insensitive [(3)H]Ro 15-4513 (2 nM) binding in

196 Studies with mutant mice harboring diazepam-insensitive alpha-subunits alpha1, alpha2, alph

197 etically modified mice (alpha1 H101R) with a diazepam-insensitive alpha1 subtype and a selective BZ s

198 a1(H101R) homozygous knockin mice expressing diazepam-insensitive alpha1-GABA(A) receptors, global al

199 on confers diazepam sensitivity to otherwise diazepam-insensitive alpha4beta3delta receptors.

200 pus of CIE rats, confirmed by an increase in diazepam-insensitive binding for ethyl-8-azido-5,6-dihyd

201 (1)(0/0) mice and mice engineered to express diazepam-insensitive receptors (alpha(1H101R), alpha(2H1

202 is either very small or nonexistent in this diazepam-insensitive subtype (see Figure 16 for details)

203 hesia) were given propranolol, reserpine, or diazepam intraperitoneally before (18)F-FDG injection to

204 lying tolerance to the anxiolytic effects of diazepam is different from that underlying tolerance to

205 In vivo, diazepam is neuroprotective when given early after ische

206 Tolerance to the anticonvulsant action of diazepam is present in an early phase (6, 24, and 36 h)

207 Although the motor-depressant action of diazepam is suppressed in alpha1(H101R) homozygous knock

208 d other benzodiazepine drugs, in addition to diazepam itself.

209 maging in Thy1-GFP(M) mice demonstrated that diazepam limited microglial engulfment of neuronal eleme

210 diazepine stabilization period taking either diazepam, lorazepam, or alprazolam, patients were treate

211 We found that diazepam loses its antiseizure efficacy and conversely e

212 Thus, after oxygen-glucose deprivation, diazepam may decrease neuronal excitability, thereby red

213 oral clonidine pre-treatment on intravenous diazepam/meperidine sedation using the bi-spectral index

214 nstrated to be applicable to the analysis of diazepam metabolites and other benzodiazepine drugs, in

215 gics, proton-pump inhibitors, nitroglycerin, diazepam, metoclopramide, acetylcysteine were associated

216 er toward diazepam was found to be 110 ng of diazepam/mg of polymer.

217 The model accounted for diazepam modulation simply by increasing the preactivati

218 We further show that the diazepam-modulation of hippocampal theta activity shows

219 An anti-diazepam, molecularly imprinted polymer (MIP) has been s

220 s silencing this circuit blocked RS67333 and diazepam mPFC infusion-induced anxiolytic effects.

221 omplex is altered with anxiolytic effects of diazepam, mRNA expression of the immediate-early gene EG

222 c protocols also frequently recommend rectal diazepam (n = 14).

223 ts were given either saline (n=5) or 5 mg/kg diazepam (n=6).

224 e termination than was treatment with rectal diazepam (n=80).

225 pines (midazolam, n = 33; lorazepam, n = 23; diazepam, n = 24), 30 recommend intramuscular benzodiaze

226 epines (midazolam, n = 30; lorazepam, n = 8; diazepam, n = 3), and 27 recommend intranasal benzodiaze

227 Further studies showed that diazepam normalized Csf1 and C3 mRNA in the PFC, and pre

228 ed phenobarbital plus three or more doses of diazepam (odds ratio 31.7 [1.2-814]).

229 Optimum retention of diazepam on the MIP columns was achieved using an apolar

230 and is a potent antagonist of the effects of diazepam only at alpha5beta3gamma2 subtypes (oocytes).

231 In contrast, benzodiazepines, such as diazepam, only potentiate currents induced by submaximal

232 Patients received either 0.2 mg/kg of diazepam or 0.1 mg/kg of lorazepam intravenously, with h

233 In the absence of diazepam or GABA, pCMBS(-) did not react at a measurable

234 y activity was reduced by the application of diazepam or low doses of baclofen.

235 iodontal surgeries under IVS with midazolam, diazepam, or placebo control.

236 enders the targeted subunit nonresponsive to diazepam, other benzodiazepines and zolpidem.

237 ators (FAM), like alprazolam, triazolam, and diazepam, PAMs are virtually devoid of unwanted side eff

238 Low doses of diazepam partially reduced the hyperlocomotion and fully

239 In the presence of 100 nM diazepam, pCMBS(-) reacted with alpha(1)F296C, alpha(1)F

240 cal midazolam and 27% (30 of 110) for rectal diazepam (percentage difference 29%, 95% CI 16-41).

241 Diazepam potentiation and Zn2+ inhibition demonstrated t

242 effect on desensitization, deactivation, or diazepam potentiation of GABA-mediated currents.

243 P altered desensitization, deactivation, and diazepam potentiation of GABA-mediated currents.

244 terestingly, the R43Q mutation did not alter diazepam potentiation.

245 show that, with low concentrations of GABA, diazepam produces a biphasic potentiation for the alpha1

246 Consistent with augmented GABAA signaling, diazepam provoked intracellular acidosis in macrophage,

247 GYKI-52466 terminated diazepam-refractory SE.

248 Patients on diazepam required an average of 15 minutes longer to rec

249 dosages of 3.3 and 12.1 mg for midazolam and diazepam, respectively.

250 cal correction of gamma2-mediated IPSCs with diazepam restored total EEG power toward baseline, but h

251 e, treatment with the benzodiazepine agonist diazepam restores LTD in GAD 65 (-/-) mice.

252 , we assessed whether chronic cocaine alters diazepam's anxiolytic and anticonvulsant actions.

253 sed to inhibit specifically Block A, whereas diazepam selectively manipulated flux through Block B.

254 A component of the tonic current is diazepam sensitive and is mediated by extrasynaptic rece

255 ve allosteric modulation of each of the four diazepam-sensitive alpha-subtypes in anxiety-related beh

256 o R point mutations in three out of the four diazepam-sensitive alpha-subunits in mice with a 129X1/S

257 tial agonist efficacy profile at recombinant diazepam-sensitive receptors (e.g., alpha1beta3gamma2, a

258 d a TM3 residue within rho1 subunits confers diazepam sensitivity on homo-oligomeric rho1-receptor ch

259 rate that the deltaH68A substitution confers diazepam sensitivity to otherwise diazepam-insensitive a

260 were replaced by delta subunit sequence, and diazepam sensitivity was determined.

261 Furthermore, treatment of tg mice with diazepam significantly attenuated these anxiety-like beh

262 In addition, diazepam significantly increased EGR-1 mRNA expression i

263 The recovery of a 50 ng diazepam standard spiked into blank hair was 93%, with g

264 .24 for treatment effect (diazepam versus no diazepam) suggested a meaningful difference between grou

265 tiulcer drug omeprazole, the anxiolytic drug diazepam, the beta-blocker propranolol, the antimalarial

266 While cell recruitment was unaltered by diazepam, the cytokine response to infection was affecte

267 Using nonstationary fluctuation analysis and diazepam to manipulate GABAA receptor apparent affinity,

268 Also, diazepam-treated (5 mg/kg) rats had significantly shorte

269 Diazepam treatment did not affect immune homeostasis in

270 In this study, we found that peripubertal diazepam treatment reduced heightened anxiety, decreased

271 orroborated by in vivo analyses showing that diazepam treatment significantly reduced the OD shift of

272 124 suggested a moderate effect favoring the diazepam treatment.

273 Surprisingly, diazepam treatments induce a loss of visual responses, a

274 KCNQ channel opener, with phenobarbital and diazepam, two drugs in current use for neonatal seizures

275 s, because the positive allosteric modulator diazepam unbound from GABA(A) receptors independent of G

276 but transient potentiation of GABA(A)Rs with diazepam uncovered distinct developmental vulnerabilitie

277 around 20 Hz doubled at the highest dose of diazepam used (5 mg), and returned to control levels fol

278 natives to federally scheduled drugs such as diazepam (Valium) and alprazolam (Xanax).

279 oth a diazepam binding inhibitor peptide and diazepam (Valium) can mimic SDF-2 in a Dictyostelium bio

280 Ketogenic diet, diazepam, valproate, potassium bromide and stiripentol a

281 the eta2 value of 0.24 for treatment effect (diazepam versus no diazepam) suggested a meaningful diff

282 d the binding capacity of the polymer toward diazepam was found to be 110 ng of diazepam/mg of polyme

283 rtal administration of the antianxiety agent diazepam was found to prevent the increase in DA neuron

284 Systemic diazepam was without effect.

285 development and maintenance of tolerance to diazepam, whereas excitatory amino acid-related processe

286 reased by flumazenil, unlike augmentation by diazepam which is blocked by flumazenil.

287 Thus, diazepam, which binds to the extracellular domain, induc

288 offset of plasticity, and was substituted by diazepam, which enhances GABA function.

289 compared these effects to those of systemic diazepam, which failed to increase social behavior.

290 Classical BZ full agonists such as diazepam, which maximally enhance the function of GABA-A

291 (A)R sensitivity, respectively, to Zn(2+) or diazepam, which suggests that these deltaL2-induced chan

292 ects of THC at lower doses resemble those of diazepam, whose locomotion- and temperature-decreasing e

293 ts were treated with intermittent boluses of diazepam with an average total and maximal individual do

294 rial with 53 schizophrenic patients compared diazepam with placebo (with fluphenazine treatment for a

295 ce ethanol and zolpidem withdrawal, but that diazepam withdrawal may be less influenced by these gene

296 , which are normal during the early phase of diazepam withdrawal, increase by approximately 30% in co

297 ithdrawal, but differed less robustly during diazepam withdrawal.

298 appearance of signs of dependence 96 h after diazepam withdrawal.

299 pparent 96 h (but not 12, 24, or 48 h) after diazepam withdrawal.

300 It was therefore hypothesized that diazepam would block both contextual fear and the concom