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1 t from a chromatid dicentric to a chromosome dicentric.
2 gnificantly alter the yield of X-ray-induced dicentrics.
3 pTRS-63, have been indicated for most of the dicentric 14q21q and 13q14q translocations that have bee
4  sequences downstream of c-myc, generating a dicentric (15;12) chromosome as an amplification interme
5                          For construction of dicentrics, a modified B-9 chromosome was used, B-9-Dp9.
6 of nonlethal stable translocations to lethal dicentric aberrations be unity and not change with radia
7  Gy X-rays were given and chromosome damage (dicentrics, acentric fragments, micronuclei, chromatid g
8 trast analysis of the cellular response upon dicentric activation reveals that the majority of cells
9                                              Dicentric anaphase chromatin bridges and structurally al
10 , at the same time reducing the frequency of dicentric and abnormal chromosomes.
11 ely 1-5 kb) frequently fuse to form unstable dicentric and acentric chromosomes.
12 s we show rob(15;21)c to be constitutionally dicentric and breakage-fusion-bridge cycles generate dic
13 5 ug/ml MNU or 10 uM H(2)O(2) hardly induced dicentrics and did not significantly alter the yield of
14 type aberrations, including gaps and breaks, dicentrics and radial formations, following exposure to
15 earance of chromosome aberrations (including dicentrics and ring forms) in peripheral blood lymphocyt
16 omeric fusions, resulting in translocations, dicentrics, and circular chromosomes.
17 tic septa pinch the nucleus, suggesting that dicentrics are severed after actomyosin ring contraction
18 the duplicated region gives a chromatid-type dicentric B-9 that subsequently initiates a chromatid-ty
19 replication origin.(1) Here, we discovered a dicentric bacterial chromosome with two replication orig
20 ning chromosomes normally display occasional dicentric behavior, suggesting that bWD has centromeric
21  "Healing" of broken chromosomes produced by dicentric breakage accounted for much of the dicentric l
22                                In all cases, dicentric breakage requires anaphase exit, ruling out st
23 c fragment is lost when cells divide and the dicentric breaks, transmitting a chromosome that has los
24 gH DSBs in progenitor B cells and that these dicentrics can be propagated developmentally into mature
25 isms, we find that attempts to segregate the dicentric chromatid frequently result not in breakage, s
26 etochore protein dephosphorylation regulates dicentric chromatid segregation.
27 nverted region results in the formation of a dicentric chromatid, which usually breaks or is stretche
28 eproduction theory," where a complete set of dicentric chromatids is synthesized during gametogenesis
29                                          The dicentric chromosome (DCA) and cytokinesis-block micronu
30             We find that cell survival after dicentric chromosome activation requires the MT-binding
31   Finally, we show that stabilization of the dicentric chromosome after breakage involves telomere ca
32 able chromosome to induce the formation of a dicentric chromosome and an acentric, telomere-bearing,
33    The nilgai karyotype contains an apparent dicentric chromosome as evidenced by the sites of 1.715
34 es of the RENEB network, which performed the dicentric chromosome assay (manual and/or semi-automatic
35       Centromeres on the same chromatid of a dicentric chromosome attach to opposite poles approximat
36                               Suppression of dicentric chromosome breakage reflects loss of kinetocho
37 ated sequence and a telomere, suggesting the dicentric chromosome breaks and repairs by recombination
38 nter-chromosomal translocations that lead to dicentric chromosome bridge formation and breakage.
39 sister chromatids following the rupture of a dicentric chromosome during mitosis.
40 ient to completely inhibit radiation-induced dicentric chromosome formation had no effect on the freq
41 ption readthrough phenotype and stabilizes a dicentric chromosome fragment in two assays for kinetoch
42 ced between two centromeres on a conditional dicentric chromosome in budding yeast cells and made vis
43             Using a conditionally functional dicentric chromosome in vivo, we demonstrate that kineto
44 icates that these CNVs appear to arise via a dicentric chromosome intermediate and breakage-fusion-br
45 ethodology also involves the generation of a dicentric chromosome intermediate, which subsequently un
46 rted repeats in budding yeast fuse to form a dicentric chromosome intermediate, which then rearranges
47 ty, we introduced a conditionally functional dicentric chromosome into yeast.
48 d in G1 creating a dicentric chromosome, the dicentric chromosome is replicated, and as dicentric sis
49                 Activation of a facultative, dicentric chromosome provides a unique opportunity to in
50 yKU70, yKU80, or SIR2, a 10-kb region of the dicentric chromosome stretched along the spindle axis to
51 matin relaxation following the breakage of a dicentric chromosome subjected to microtubule-based spin
52 al centromere is activated, the functionally dicentric chromosome undergoes double-stranded DNA break
53                              The fate of the dicentric chromosome was evaluated in the mitotic cells
54                       When two copies of the dicentric chromosome with one active and one inactive ce
55 radiator, we present dose rate dependence of dicentric chromosome yields.
56 4 chromosomes, monosomy 7, the presence of a dicentric chromosome, or both predicted a worse EFS but
57 ighbourhood is translocated in G1 creating a dicentric chromosome, the dicentric chromosome is replic
58 tive to cleavage following activation of the dicentric chromosome.
59  to collapse and buckle in the presence of a dicentric chromosome.
60 phila melanogaster by breakage of an induced dicentric chromosome.
61 ce of telomerase but not after breakage of a dicentric chromosome.
62 lacO region in response to activation of the dicentric chromosome.
63 tions at M1 and the end fusions that produce dicentric chromosomes and breakage-fusion cycles.
64 stream of c-myc on chromosome 15, generating dicentric chromosomes and c-myc amplification via a brea
65 ncluding non-homologous chromosomal fusions, dicentric chromosomes and megabase-size telomeric deleti
66                                              Dicentric chromosomes are unstable products of erroneous
67 cell cycles, highlighting the common role of dicentric chromosomes as initiating events.
68 atid exchange between inverted FRTs produced dicentric chromosomes at a high rate.
69 the response did not result from breakage of dicentric chromosomes at mitosis.
70 ore reproduction theory are: (i) breakage of dicentric chromosomes between centromere pairs forms acr
71                                We found that dicentric chromosomes break in mitosis, and the broken f
72          Apoptosis was not due to rupture of dicentric chromosomes formed by end-to-end fusion, indic
73 rise through TREX1-mediated fragmentation of dicentric chromosomes formed in telomere crisis.
74                                The resulting dicentric chromosomes have been proposed to drive genome
75                     This analysis shows that dicentric chromosomes have recombination breakpoints tha
76                Thus, faithful segregation of dicentric chromosomes in bacteria can occur because of s
77 n arrest, and are resolved into acentric and dicentric chromosomes in G2.
78 o an unusual mechanism for the processing of dicentric chromosomes in mammalian oogenesis.
79 two kinetochores of engineered, unreplicated dicentric chromosomes in Saccharomyces cerevisiae bi-ori
80                  We investigated the fate of dicentric chromosomes in the mitotic divisions of Drosop
81 s to wheat, often leading to the presence of dicentric chromosomes in the subsequent progeny.
82                             We observed that dicentric chromosomes invariably persisted through mitos
83                                        Thus, dicentric chromosomes may be an important precipitant of
84                    Breakage of the resulting dicentric chromosomes results in nonreciprocal transloca
85                            Immunostaining on dicentric chromosomes reveals that an inactive centromer
86 c and breakage-fusion-bridge cycles generate dicentric chromosomes somatically.
87 etaphase cells correlated with high level of dicentric chromosomes specifically in primary but not in
88                                 In contrast, dicentric chromosomes that do not exhibit knotted DNA fa
89 ome tumour cells, like senescent cells, have dicentric chromosomes that may arise as a result of telo
90      Mutations in chl4/mcm17/ctf17 segregate dicentric chromosomes through successive cell divisions
91  unwinding, we used conditionally functional dicentric chromosomes to exert tension.
92 alpha-satellite-rich inactive centromeres of dicentric chromosomes together suggest that CENP-A assoc
93 protein has been reported to be recruited to dicentric chromosomes under tension, and such chromosome
94                                              Dicentric chromosomes undergo a breakage-fusion-bridge c
95                                              Dicentric chromosomes undergo breakage in mitosis, resul
96 bility phenotype consisting of segmented and dicentric chromosomes with mosaic variegated hyperploidy
97                    Cells initially tolerated dicentric chromosomes without dying, but eventually, a c
98 n of the telomere reserve generates unstable dicentric chromosomes(1-5).
99 ease TREX1, which promotes the resolution of dicentric chromosomes(4), plays a prominent role in chro
100 tative changes (a shift from TAs to TAs plus dicentric chromosomes) and quantitative changes (an incr
101 lect a cycle of T-TF formation (resulting in dicentric chromosomes), followed by chromosome breakage.
102 y comparisons based on the manual scoring of dicentric chromosomes, a tendency for systematic overest
103 also observe an increase in the formation of dicentric chromosomes, anaphase bridges, and intercellul
104 B is found at inactive centromeres on stable dicentric chromosomes, and also mitotically stable chrom
105  had telomere sequences added to resolve the dicentric chromosomes, and only one BFB breakpoint showe
106 of numerous chromosome aberrations including dicentric chromosomes, chromatid breaks, and double minu
107 rrations, including increases in aneuploidy, dicentric chromosomes, chromatid exchanges and chromosom
108  long lasting and transmissible induction of dicentric chromosomes, nucleoplasmic bridges, micronucle
109 ents within palindromes that create unstable dicentric chromosomes, resulting in infertility, sex rev
110 d to the formation and sometimes breakage of dicentric chromosomes, thus starting a devastating break
111   This inverted repeat fusion reaction forms dicentric chromosomes, which are well-known intermediate
112  become apparent that that the resolution of dicentric chromosomes, which arise from telomere fusions
113 omosome of maize has been used in a study of dicentric chromosomes.
114 bridge cycles and chromothripsis of unstable dicentric chromosomes.
115 hing between nearby inverted repeats to form dicentric chromosomes.
116     TAs preceded and were more numerous than dicentric chromosomes.
117 gh TAs before additional shortening leads to dicentric chromosomes.
118 ycle was examined for the presence of stable dicentric chromosomes.
119  end of the chromosome, and the formation of dicentric chromosomes.
120  emergence of chromosomal fusions (including dicentrics) coincided with onset of deletions and comple
121 ventually, a combination of too many TAs and dicentrics/complex chromosomal rearrangements resulted i
122  chromosomes were recovered from an unstable dicentric containing large and small versions of the B c
123 a model explaining the formation of inverted dicentric dimers by intermolecular single-strand anneali
124 to this model, anaphase breakage of inverted dicentric dimers leads to gross chromosomal rearrangemen
125                                          The dicentrics form anaphase bridges that subsequently break
126                              We propose that dicentrics formed by joining V(D)J recombination-associa
127                                     By using dicentrics from dispensable chromosomes, centromere inac
128                            In budding yeast, dicentrics generated by telomere fusion break at the fus
129  This involved introduction of a 15-megabase dicentric genetic element, composed of 11 fragments of s
130                 Here, we examine the fate of dicentric human chromosomes in telomere crisis.
131                      The three cytologically dicentric i(Xq)s had breakpoints distal to DXS423E in Xp
132 this study, we map chromosome break sites of dicentrics in Saccharomyces cerevisiae by a mitotic reco
133 that the arrest represents surveillance of a dicentric induced aberration.
134 structures observed suggest involvement of a dicentric intermediate and break-induced replication wit
135 further results in intact segregation of the dicentric into one of the meiotic products, where it can
136 me that is subsequently replicated to form a dicentric inversion chromosome.
137 repeats, resulting in the formation of large dicentric inverted dimers.
138 st cases had deletions of 9p, add/der(9p), a dicentric involving chromosome arm 9p, and/or balanced t
139 me that is subsequently replicated to form a dicentric isochromosome.
140 ants, potential dicentric translocations and dicentric isochromosomes were associated with cell cycle
141                       Here, we observed that dicentrics lacking telomere fusion preferentially break
142 there was no specific developmental time for dicentric loss.
143 dicentric breakage accounted for much of the dicentric loss.
144    Fusion of nearby inverted repeats to form dicentrics may be a major cause of instability in yeast
145 at the minichromosome segregation defect and dicentric minichromosome stabilization, both characteris
146 d neck, explaining how cytokinesis can sever dicentrics near centromeres.
147           Here, we report that selecting for dicentric recombinants through male crosses uncovers sta
148  complex chromosomal abnormalities including dicentrics, rings and fragments.
149 e dicentric chromosome is replicated, and as dicentric sister chromosomes segregate during mitosis, a
150         Most Robertsonian translocations are dicentric, suggesting that the location of chromosomal b
151                                          The dicentric t(8;11) in ZR-75-1 carries multiple rearrangem
152                           In the presence of dicentrics, the cytokinetic septa pinch the nucleus, sug
153 to one pole and converts it from a chromatid dicentric to a chromosome dicentric.
154 e second pollen mitosis, which sends the B-9 dicentric to one pole and converts it from a chromatid d
155 d in telomerase-defective mutants, potential dicentric translocations and dicentric isochromosomes we
156         We have analyzed the structure of 36 dicentric translocations, using several repetitive DNA p
157      Chromosomes containing two centromeres (dicentrics) trigger chromosome instability that is avoid
158                         As expected, the new dicentric undergoes the chromosome-type breakage-fusion-
159 ficiency leads to formation of chromosome 12 dicentrics via recombination-activating gene-initiated I
160 n the root cells of plants with a chromosome dicentric was studied during the first 10 wk of developm
161     A large number of plants with chromosome dicentrics were produced in this way.
162 eakpoints of cytogenetically monocentric and dicentric Xq isochromosomes (i(Xq)) from Turner syndrome

 
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