ライフサイエンスコーパス: diclofenac

1 he predominant cause of adverse reactions to diclofenac.

2 carbon and nitrogen isotope measurements of diclofenac.

3 reater than the proposed EQS of 100 ng/L for diclofenac.

4 -fold increase in acute toxicity compared to diclofenac.

5 eved from rats receiving only caspofungin or diclofenac.

6 s topical nepafenac relative to ketorolac or diclofenac.

7 , 48 min with flurbiprofen, and 0.8 min with diclofenac.

8 ater affinity for DMPC bilayers than anionic diclofenac.

9 itor etoricoxib versus the traditional NSAID diclofenac.

10 ited by miconazole and, to a less extent, by diclofenac.

11 % CI 0.81-1.11) for etoricoxib compared with diclofenac.

12 itor etoricoxib versus the traditional NSAID diclofenac.

13 ting from 2 weeks' ingestion of slow-release diclofenac.

14 among all lumiracoxib dosages and similar to diclofenac.

15 arable efficacy and superior tolerability to diclofenac.

16 s entered the trial, and 110 received rectal diclofenac.

17 rybdotoxin, or the cyclooxygenase inhibitor, diclofenac.

18 e, 6-keto PGF(1alpha), that was abolished by diclofenac.

19 ly those with strong COX2 inhibition such as diclofenac.

20 l and engineered transformation reactions of diclofenac.

21 n reactions within the environmental life of diclofenac.

22 ral NSAIDs and acetaminophen with or without diclofenac.

23 vents were similar for etoricoxib (0.30) and diclofenac (0.32).

24 events with etoricoxib than there were with diclofenac (0.57, 0.45-0.74; p<0.0001); there was no dif

25 ulcer) were lower with etoricoxib than with diclofenac (0.67 vs 0.97 per 100 patient-years; hazard r

26 Twelve analogues of diclofenac (1), a nonsteroidal antiinflammatory drug and

27 Diclofenac (100 muM) inhibited KCNQ5 channels, reducing

28 I also occurred in 1 of 9480 patients taking diclofenac (11 of 100,000; 95% CI, 4-24), 1 of 133 patie

29 risons of etoricoxib (60 or 90 mg daily) and diclofenac (150 mg daily) in 34 701 patients with osteoa

30 gned to etoricoxib (60 mg or 90 mg daily) or diclofenac (150 mg daily).

31 y assigned to etoricoxib (60 or 90 mg qd) or diclofenac (150 mg qd).

32 Two days later, a single intravenous dose of diclofenac (2 mg/kg) (treated animals) was given, and af

33 uoromethyl)phenyl]amino}nicotinic acid], and diclofenac [2-(2-(2,6-dichlorophenylamino)phenyl)acetic

34 star rats (8 weeks old) were pretreated with diclofenac (20 mg/kg, s.c.) or saline, followed by intra

35 were randomized to one of two groups, 75 mg diclofenac + 200 microg misoprostol twice daily or 1,000

36 25 mg of rofecoxib once daily, and 50 mg of diclofenac 3 times daily.

37 ut dextromethorphan O- and N-demethylations, diclofenac 4'-hydroxylation, and phenacetin O-deethylati

38 rate absorption group, every 30 minutes: for diclofenac 5%-15%-30%-50%, and for celecoxib, 20%-80%.

39 ere amoxicillin-clavulanate (21 of 96; 22%), diclofenac (6%), azathioprine (4%), infliximab (4%), and

40 wice daily or 400 mg once daily; placebo; or diclofenac 75 mg twice daily.

41 ted aspirin two hours before delayed-release diclofenac (75 mg twice daily)

42 age, 26 y; 42% female) were given the NSAID diclofenac (75 mg twice daily) plus omeprazole (20 mg on

43 rofen, 800 mg 3 times per day (n = 1985); or diclofenac, 75 mg twice per day (n = 1996).

44 250-4800 ng/L), carbamazepine (33-910 ng/L), diclofenac (78-1000 ng/L), carbendazim (21-900 ng/L), di

45 physiological characteristics and effects of diclofenac, a known KCNQ channel activator, on human KCN

46 ortantly, inhibition of PGE2 production with diclofenac, a nonselective COX inhibitor, resulted in re

47 Diclofenac, a nonsteroidal anti-inflammatory drug inhibi

48 Diclofenac accumulated in a concentration- and time-depe

49 In this study, the THz spectra of two diclofenac acid polymorphs were obtained by THz spectros

50 ither diclofenac sodium solution (0.3 mg) or diclofenac acid suspension (10 mg) prepared in 0.1 mL ba

51 se distribution or depot compartment for the diclofenac acid suspension in the posterior segment.

52 and the retina-choroid even on day 21 after diclofenac acid suspension injection, with retina-choroi

53 Diclofenac acid was prepared and characterized in a susp

54 Diclofenac acid with an approximate 5-mum particle size

55 oosing a less soluble form of a drug such as diclofenac acid, vitreous elimination half-life can be p

56 bolites may lead to higher levels of protein-diclofenac adducts and subsequently hepatotoxicity.

57 lity by using immunohistochemistry to detect diclofenac adducts.

58 c acid, and a phenyl acetic acid derivative, diclofenac, also are low-potency (EC(50) = 80 muM to 2.1

59 ancreatitis (11%), of whom 7 received rectal diclofenac and 17 received placebo (P < 0.05).

60 ticular (15)N corroborated transformation of diclofenac and bentazone.

61 rieved from rats that were treated with both diclofenac and caspofungin contained significantly fewer

62 Lumiracoxib tolerability was superior to diclofenac and comparable to placebo.

63 Diclofenac and etoricoxib accounted for one-third of tot

64 aluate the approach for two pharmaceuticals (diclofenac and fluoxetine) and one personal care product

65 IgEs to most frequently used NSAIDs such as diclofenac and ibuprofen are urgently needed.

66 lorobenzamide (BAM), and the pharmaceuticals diclofenac and ibuprofen was released into a mesoscale a

67 (similar range as potent inhibitors such as diclofenac and indomethacin in the same experimental con

68 so extended to non-selective NSAIDs, such as Diclofenac and Ketoprofen.

69 er currently approved therapeutics including diclofenac and minocycline.

70 receptor antagonist and clinically by use of diclofenac and pancreatic duct stenting.

71 In this instrumental variable analysis, diclofenac and rofecoxib had the least favorable benefit

72 superiority to the cyclooxygenase inhibitors diclofenac and rofecoxib.

73 the most recalcitrant micropollutants (i.e., diclofenac and targeted sulfonamides).

74 nd rapidly transferred to the sorbent (e.g., diclofenac) and (2) more hydrophobic chemicals accumulat

75 n, 5-fold higher for the 4'-hydroxylation of diclofenac, and 3-fold higher for the omega-1 hydroxylat

76 ncentrations of carbendazim, clarithromycin, diclofenac, and diuron exceed levels of ecotoxicological

77 etylsalicylic acid, acetaminophen, atenolol, diclofenac, and ibuprofen were tested as target analytes

78 steroidal antiinflammatory drugs (celecoxib, diclofenac, and indomethacin), a p38 MAPK inhibitor, SB2

79 uch as ibuprofen, naproxen sodium, etodolac, diclofenac, and ketorolac in this prototypic condition o

80 YP2C9*5 were carried out using (S)-warfarin, diclofenac, and lauric acid as substrates.

81 Cimetidine, diclofenac, and miconazole, known inhibitors of CYP450 2

82 in, carbamazepine, moxifloxacin, cephalexin, diclofenac, and nitrofurantoin.

83 used pharmaceutical compounds (S-ibuprofen, diclofenac, and S-warfarin) by one of the major drug-met

84 photodynamic therapy, nicotinamide, topical diclofenac, and selenium) and immunosuppression regimes

85 inants (viz., methyl paraben, butyl paraben, diclofenac, and triclosan) from exposed mussels on the b

86 uprofen but not rofecoxib, acetaminophen, or diclofenac antagonizes the irreversible platelet inhibit

87 ces were used to investigate polyclonal anti-diclofenac antibodies recognition and reversibility usin

88 Celecoxib, rofecoxib, and diclofenac are clinically used cyclooxygenase-2 (COX-2)

89 We propose that residues of veterinary diclofenac are responsible for the OWBV decline.

90 Here, we have used diclofenac as a model compound to study the impact of bi

91 that endorsed by the first EU Watch List for diclofenac as a potentially emerging contaminant in seaw

92 ss favorable cardiovascular risk profile for Diclofenac as compared to Ketoprofen is reported, the me

93 ug-like molecules, including salicylates and diclofenac, as MR1-binding ligands.

94 caine), or mixed pain (ketamine, gabapentin, diclofenac, baclofen, cyclobenzaprine, and lidocaine), o

95 ruct the biosensor, the amino-functionalized diclofenac binding aptamer (DBA) was covalently immobili

96 that the nonsteroidal anti-inflammatory drug diclofenac binds a single monomer of native huPGHS-2, ha

97 clofenac with murine COX-2 demonstrates that diclofenac binds to COX-2 in an inverted conformation wi

98 proxen, nonylphenol, octylphenol, ibuprofen, diclofenac, bisphenol A, and triclosan.

99 The structure of the anti-inflammatory drug diclofenac bound in the active site of rabbit microsomal

100 ete loss of activity toward (S)-warfarin and diclofenac, but preservation of pyrene metabolism.

101 Here we quantified the uptake of diclofenac by the fathead minnow (Pimephales promelas) f

102 ketamine, norketamine, O-desmethyltramadol, diclofenac, carbamazepine, and methoxetamine were not su

103 apped reactive metabolites of acetaminophen, diclofenac, carbamazepine, clozapine, p-cresol, 4-ethylp

104 It was found that the wastewater borne MPs diclofenac, carbamazepine, sulfamethoxazole, acesulfame,

105 The proximity of the diclofenac carboxylate to the side chain of D290 togethe

106 Neither flurbiprofen nor diclofenac changed the EPR line width when added after p

107 hannels endogenously, and their responses to diclofenac closely resembled those of the overexpressed

108 Acetaminophen, diclofenac, codeine, ampicillin, tetracycline, erythromy

109 ghlight the dose-dependent cardiotoxicity of Diclofenac compared to Ketoprofen.

110 ver in hippocampus, while pre-treatment with diclofenac completely prevented these neurochemical resp

111 mucosa and to describe the interactions with diclofenac, considering the pH gradient found in the gas

112 -1) for MCPA, 2,4-D, mecoprop, atenolol, and diclofenac, corresponding to half-lives of 0.6-6.3 h, de

113 This report indicates that diclofenac could be useful in combination therapy with c

114 The first one is a molecular probe, diclofenac, coupled with an arylamine onto which a speci

115 we encapsulated the cell death-inducing drug Diclofenac (DCF) in an electrospun poly-L-lactide (PLA)

116 tection of the pharmaceutical micropollutant diclofenac (DCF) in water.

117 A) for the detection of carbamazepine (CBZ), diclofenac (DCF), caffeine (CAF), and isolithocholic aci

118 emove an anionic pharmaceutical product, the diclofenac (DCF), recognized as a recalcitrant compound

119 The affinity of the anionic pharmaceutical, diclofenac (DCF), to the composite was high and did not

120 by investigating the metabolism of the drugs diclofenac (DCF), troglitazone (TGZ), and raloxifene, fo

121 mical aptasensor for the detection of sodium diclofenac (DCF).

122 lonN = -7.1 per thousand), whereas reductive diclofenac dechlorination was associated with significan

123 Noteworthy, Diclofenac decreases the proteasome 26S DC and this scen

124 is stated that etoricoxib is not inferior to diclofenac, defined as an upper boundary of less than 1.

125 analysis bears potential not only to detect diclofenac degradation, but even to distinguish both tra

126 -specific isotope analysis (CSIA) may detect diclofenac degradation.

127 This study showed that diclofenac delayed both T(max) and T1/2.

128 All S-NO-diclofenac derivatives acted as orally bioavailable prod

129 nsteroidal anti-inflammatory drugs (NSAIDs), diclofenac (Dic) and naproxen (Nps), were studied by X-r

130 ministration of rofecoxib, acetaminophen, or diclofenac did not affect the pharmacodynamics of aspiri

131 Neutral diclofenac displayed greater affinity for DMPC bilayers

132 The diclofenac-DMPC interactions were clearly dependent on t

133 Celecoxib, but not rofecoxib or diclofenac, dramatically enhanced KCNQ (K(v)7) potassium

134 r etoricoxib than with the traditional NSAID diclofenac due to a decrease in uncomplicated events, bu

135 Inhibition of PGE2 synthesis by diclofenac enhanced collagen production in skin organ cu

136 Three drugs (rofecoxib, diclofenac, etoricoxib) ranked consistently highest in t

137 -EME of ibuprofen, ketoprofen, naproxen, and diclofenac exceed 40% in real samples.

138 Neutral or anionic diclofenac exerted distinct alterations in phosphatidylc

139 ected to tolerable stress events, conversely Diclofenac exposition triggers cell death.

140 al, and proteasome activity modulation, only Diclofenac exposure shows a marked alteration of these i

141 The drugs diclofenac, fluoxetine, and gemfibrozil belong to differ

142 e and uptake of (14)C-labeled carbamazepine, diclofenac, fluoxetine, and orlistat in soil-earthworm s

143 aged 22-77 (mean, 52) years who were taking diclofenac for 0.3-20 (mean, 4) years without developing

144 7 days, and artificial tears, ketorolac, and diclofenac four times daily for 14 days.

145 her energy thermodynamic solid-state form of diclofenac free acid and an intriguing conversion to liq

146 able predictions of uptake of fluoxetine and diclofenac from a sediment.

147 5 of the chemicals (bezafibrate, climbazole, diclofenac, furosemide, and hydrochlorothiazide), the me

148 r the removal of the anionic micropollutants diclofenac, gemfibrozil and ibuprofen from EfOM.

149 Cs (metoprolol, bezafibrate, clofibric acid, diclofenac, gemfibrozil, ibuprofen, ketoprofen, naproxen

150 cetazolamide, beclomethasone, carbamazepine, diclofenac, gemfibrozil, ibuprofen, ketoprofen, norethin

151 y with increasing neutral fraction of acids (diclofenac, genistein, naproxen, torasemide, and warfari

152 This trial shows that rectal diclofenac given immediately after endoscopic retrograde

153 We then compare the pNPG and diclofenac glucuronide processing abilities of a panel o

154 ients in the etoricoxib group and 323 in the diclofenac group had thrombotic cardiovascular events, y

155 Diclofenac has a risk very similar to rofecoxib, which w

156 cantly less common with etoricoxib than with diclofenac (hazard ratio [HR] 0.69, 95% CI 0.57-0.83; p=

157 nts per 100 patient-years for etoricoxib and diclofenac (hazard ratio [HR] = 0.84; 95% confidence int

158 The UGT2B7*2 allele was more common in diclofenac hepatotoxicity patients compared with hospita

159 ed 24-70 (mean, 50.8) years who had suffered diclofenac hepatotoxicity, 48 subjects (35 female) aged

160 e diclofenac metabolites are associated with diclofenac hepatotoxicity.

161 efficacy, safety, and local tolerability of diclofenac HPbetaCD administered as a local submucosal i

162 ficacy, safety, and relative tolerability of diclofenac HPbetaCD used locally as a submucosal injecti

163 ication ranged between 7.8 h (for 25 mg/1 mL diclofenac HPbetaCD) and 16 h (for 50 mg/1 mL diclofenac

164 iclofenac HPbetaCD) and 16 h (for 50 mg/1 mL diclofenac HPbetaCD).

165 ere randomized into 1 of 5 groups: 5 mg/1 mL diclofenac HPbetaCD, 12.5 mg/1 mL diclofenac HPbetaCD, 2

166 5 mg/1 mL diclofenac HPbetaCD, 12.5 mg/1 mL diclofenac HPbetaCD, 25 mg/1 mL diclofenac HPbetaCD, 50

167 12.5 mg/1 mL diclofenac HPbetaCD, 25 mg/1 mL diclofenac HPbetaCD, 50 mg/1 mL diclofenac HPbetaCD, or

168 , 25 mg/1 mL diclofenac HPbetaCD, 50 mg/1 mL diclofenac HPbetaCD, or 1 mL placebo.

169 revealed an enhanced removal of atorvastatin-diclofenac-hydrochlorothiazide (during the whole treatme

170 Nine cases of diclofenac hypersensitivity recorded by the Allergy Vigi

171 tive NSAIDs used in the development program (diclofenac, ibuprofen, and nabumetone).

172 0 days after initiation of NSAID (rofecoxib, diclofenac, ibuprofen, and naproxen compared with celeco

173 valdecoxib), as well as oral formulations of diclofenac, ibuprofen, naproxen, and a composite of all

174 bations, including acetaminophen, clozapine, diclofenac, imipramine, meclofenamic acid, and ticlopidi

175 ger term chronic health effects analysis for diclofenac in fish.

176 The LC(50) of diclofenac in H. azteca was 216 mg L(-1), while that of

177 The ultratrace determination of diclofenac in high matrix samples, e.g., seawater, witho

178 the effects of Ketoprofen in comparison with Diclofenac in immortalized human cardiomyocytes.

179 le prodrugs, producing significant levels of diclofenac in plasma within 15 min after oral administra

180 ay result in increased concentration of free diclofenac in plasma.

181 n turn is inappropriate for determination of diclofenac in seawater at the levels endorsed by the EU

182 was greatly affected by in vitro exposure to diclofenac in T. scabrous also (IC50 = 6.86 +/- 1.4 muM)

183 sensor is selective and is able to quantify diclofenac in tap water.

184 Remarkable changes were induced by neutral diclofenac in the structural properties of the phospholi

185 ttenuated by endothelial NO and abolished by diclofenac indicating the functional importance of B2R-i

186 st, the slow, time-dependent COX inhibitors (diclofenac, indomethacin, and flurbiprofen) were unaffec

187 compare the potencies of aspirin, celecoxib, diclofenac, indomethacin, lumiracoxib, meloxicam, naprox

188 Therefore, neutral diclofenac-induced changes in the structural properties

189 ntiating effect on allyl isothiocyanate- and diclofenac-induced currents of TRPA1 was isolated from t

190 to clarify the topical mechanisms underlying diclofenac-induced gastric toxicity by considering for t

191 Interestingly, diclofenac inhibition was unaffected by the mutation of

192 ified Ser530 to inhibit the enzyme, and that diclofenac inhibits PGH(2) but not 15-hydroperoxyeicosat

193 The carboxylate of diclofenac interacts strongly with the CYP2C9 Arg108 sid

194 nd BFCOD) systems, especially in the case of diclofenac interference with BFCOD activity (IC50 = 15.7

195 Diclofenac is a widely used nonsteroidal anti-inflammato

196 Although diclofenac is frequently found in aquatic systems, its d

197 Diclofenac is one of the most widely prescribed nonstero

198 he grafted molecular probe; conversely, when diclofenac is present in solution, a displacement equili

199 d binding affinity at lower pH suggests that diclofenac is protonated when bound to the enzyme.

200 nalysis showed that flutamide, troglitazone, diclofenac, isoniazid, and tamoxifen were reported to ha

201 , the latter method enables determination of diclofenac isotope ratios down to the sub-mugL(-1) range

202 and the nonsteroidal anti-inflammatory drug diclofenac, it has been shown that removal of the glucur

203 eceive either IV-PCA enhanced with ketorolac/diclofenac (IV-PCA, n = 66) or TEA (n = 77) within an en

204 domethacin, sulindac, ketoprofen, ibuprofen, diclofenac, ketorolac, etc., cyclooxygenase inhibitors)

205 ts increased in the order of carbamazepine < diclofenac < fluoxetine < orlistat.

206 14)C, increased in the order carbamazepine < diclofenac < fluoxetine and orlistat.

207 ed that the dissipation half-lives (DT50) of diclofenac (<0.1-1.4 days), bezafibrate (<0.1-4.8 days),

208 8, which determine the formation of reactive diclofenac metabolites and in ABCC2 encoding the transpo

209 o the formation and accumulation of reactive diclofenac metabolites are associated with diclofenac he

210 ex vivo and in vivo, while others, including diclofenac metabolites, were agonists.

211 taurine conjugate (DCF-M403) and unexpected diclofenac methyl ester (DCF-M310.03).

212 Rectal diclofenac might provide a simple, cheap alternative but

213 e events were more common when patients took diclofenac + misoprostol (P = 0.046).

214 Differences favoring diclofenac + misoprostol over acetaminophen were greater

215 vement in the primary outcomes were seen for diclofenac + misoprostol than for acetaminophen (P < 0.0

216 mprovements in pain scores over 6 weeks with diclofenac + misoprostol than with acetaminophen, althou

217 Diclofenac + misoprostol was rated as "better" or "much

218 wild bream and roach living in a lake where diclofenac, naproxen, and ibuprofen are present as pollu

219 The observed bile concentrations of diclofenac, naproxen, and ibuprofen in bream ranged from

220 The potencies of diclofenac, naproxen, rofecoxib, and salicylate, but not

221 Given the risks of a direct challenge to diclofenac, OC to aspirin should be performed first to e

222 to 8.40]) and celecoxib versus ibuprofen or diclofenac (odds ratio, 0.77 [CI, 0.40 to 1.48]).

223 es and distinct voltage-dependent effects of diclofenac on channel activation and deactivation observ

224 ted the effects of celecoxib, rofecoxib, and diclofenac on ionic currents and calcium signaling in va

225 The opposite effects of diclofenac on KCNQ4 and KCNQ5 could not be attributed to

226 ve inhibitors (nimesulide, flurbiprofen, and diclofenac) on the proportions and stability of the two

227 esthetised rats, the PG synthesis inhibitors diclofenac or indomethacin reduced muscle vasodilatation

228 given a suppository containing either 100 mg diclofenac or placebo.

229 epafenac (0.01%, 0.03%, 0.1%, or 0.5%), 0.1% diclofenac, or 0.5% ketorolac tromethamine in mice with

230 Inhibitors of COX (naproxen, diclofenac, or ibuprofen) increased bronchoconstriction

231 otic leakage, and were treated with vehicle, diclofenac, or prostaglandin E2 (PGE2), the most importa

232 d coculture plus or minus the COX-inhibitor, Diclofenac, or synthetic PGE(2) in the absence of HNSCC.

233 ients received 1000 mg paracetamol and 50 mg diclofenac, orally, to be continued on an 8-h schedule f

234 d statistical criteria, to that of 150 mg of diclofenac per day in this 1-year study.

235 ute pancreatitis as well as the finding that diclofenac prevents endoscopic retrograde cholangiopancr

236 n explorative survey, analysis of commercial diclofenac products showed significant differences in ca

237 Although diclofenac ranks among the most frequently detected phar

238 onfidence interval [95% CI] -0.20, 3.01) and diclofenac (RD 6.07, 95% CI -0.02, 12.15).

239 Diclofenac reduced adenosine-evoked NO release by ~50 %

240 lind controlled trial to determine if rectal diclofenac reduces the incidence of pancreatitis followi

241 Diclofenac residues and renal disease were reproduced ex

242 whole-cell KCNQ currents with properties and diclofenac responses characteristic of overexpressed het

243 dac, phenylbutazone, naproxen, indomethacin, diclofenac, resveratrol, curcumin, dexamethasone, celeco

244 dac, phenylbutazone, naproxen, indomethacin, diclofenac, resveratrol, curcumin, dexamethasone, celeco

245 The combination of diclofenac's uptake potential, effects on kidney nephron

246 and 293 decreased catalytic activity toward diclofenac, (S)-warfarin, and pyrene in a substrate-inde

247 Administration of diclofenac shifted the experimental renogram curves to t

248 Diclofenac should be removed from EMLs.

249 rmed but did not sorb significantly, whereas diclofenac showed both degradation and sorption.

250 a albicans biofilms grown in the presence of diclofenac showed increased susceptibility to caspofungi

251 tly less CNV, whereas eyes treated with 0.1% diclofenac showed no significant difference.

252 ral NSAIDs and acetaminophen with or without diclofenac, showed the most convincing and attractive be

253 After taking diclofenac slow-release 75 mg twice a day (with omeprazo

254 ugs, such as ketorolac tromethamine 0.5% and diclofenac sodium 0.1%, offer comparable efficacy to cor

255 Diclofenac sodium is a widely used nonsteroidal anti-inf

256 sought to determine the effect of the NSAID diclofenac sodium on monoamine turnover in brain induced

257 After diclofenac sodium salt solution injection, drug levels d

258 AUC was significantly higher at MN+diclofenac sodium sites vs. placebo, suggesting slower r

259 Rabbit eyes were injected with either diclofenac sodium solution (0.3 mg) or diclofenac acid s

260 s indicated the inability of a 10-mg dose of diclofenac sodium solution to sustain drug levels in the

261 debridement, whereas corneas pretreated with diclofenac sodium swelled only 19.2 +/- 3.1 microm (n =

262 N treatment and daily topical application of diclofenac sodium.

263 compared to 2.9 and 0.9 hours observed with diclofenac sodium.

264 omethamine; group III, 0.5% cidofovir + 0.1% diclofenac sodium; and group IV, control + artificial te

265 detection of AuNPs with a dynamic range for diclofenac spanning from 0.01 to 10 mug L(-1).

266 exceeded the predicted no-effect levels for diclofenac, sulfamethoxazole and carbamazepine, respecti

267 The elimination half-life of diclofenac suspension was 24 and 18 days in vitreous and

268 ates, including two novel products, that is, diclofenac taurine conjugate (DCF-M403) and unexpected d

269 ic acid, bisphenol A, gemfibrozil, naproxen, diclofenac, technical 4-nonylphenol, and 4-tert-octylphe

270 After diclofenac, the A(1) receptor agonist CCPA evoked no vas

271 For diclofenac, the pathway leading to the experimentally ob

272 lestradiol (EE2), 17beta-estradiol (E2), and diclofenac throughout European rivers.

273 ovocation test was performed with aspirin or diclofenac to categorize the patients according to the E

274 Furthermore, the transformation of diclofenac to its methyl ester derivative was explored i

275 t oral exposure and through feeding vultures diclofenac-treated livestock.

276 Diclofenac treatment resulted in the formation of drug a

277 Finally, the low molecular weight compound diclofenac was bound to the surface to be used as model

278 Diclofenac was by far the most commonly used NSAID, with

279 nts was due to the parent compounds but that diclofenac was degraded in the test system so uptake was

280 Diclofenac was found in five of the bream and roach samp

281 Methylation of diclofenac was further detected in fish hepatocytes and

282 Diclofenac was listed on 74 national EMLs, naproxen on j

283 Diclofenac was not found to modulate the expression of g

284 e at positive polarity; and 4'- or 5-hydroxy diclofenac was not separated by a generic UPLC method.

285 Retardation of diclofenac was reflected in additional (15)N sorption is

286 In both species, diclofenac was transformed into several oxidation produc

287 n observed (for fish exposed to 25 mug L(-1) diclofenac) was within the therapeutic range for humans.

288 Bioconcentration factors (BCFs) of diclofenac were 0.5 and 3.2 L kg(ww)(-1) in H. azteca an

289 t, the inhibitory effects of indomethacin or diclofenac, which also inhibit both cyclo-oxygenase-1 an

290 imit is ca. 20 fM, corresponding to 6pgL(-1) diclofenac, which is competitive compared to other label

291 e nonsteroidal antiinflammatory drug (NSAID) diclofenac, which is the most commonly used drug to reli

292 ome compounds (e.g., hydrochlorothiazide and diclofenac) while reducing the biodegradation of metopro

293 internal mass balance model, and apart from diclofenac, whose specific toxicity in fish had already

294 nzyme 2C5dH catalyze the 4'-hydroxylation of diclofenac with apparent K(m) values of 80 and 57 microM

295 Concurrent treatment of ketorolac or diclofenac with cidofovir did not diminish its antiviral

296 oricoxib are similar to those in patients on diclofenac with long-term use of these drugs.

297 ion of the crystal structure of a complex of diclofenac with murine COX-2 demonstrates that diclofena

298 170 women with self-administered paracetamol-diclofenac with or without TAP blocks.

299 elate residues of the anti-inflammatory drug diclofenac with renal failure.

300 nts and partial elimination for orlistat and diclofenac, with greater than 30% of the (14)C remaining